UniProtKB - P06872 (TRY2_CANLF)
Protein
Anionic trypsin
Gene
N/A
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Functioni
Catalytic activityi
- Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa. EC:3.4.21.4
Cofactori
Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 63 | Charge relay systemBy similarity | 1 | |
Metal bindingi | 75 | CalciumBy similarity | 1 | |
Metal bindingi | 77 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 80 | Calcium; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 85 | CalciumBy similarity | 1 | |
Active sitei | 107 | Charge relay systemBy similarity | 1 | |
Sitei | 194 | Required for specificityBy similarity | 1 | |
Active sitei | 200 | Charge relay systemBy similarity | 1 |
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- serine-type endopeptidase activity Source: UniProtKB
GO - Biological processi
- collagen catabolic process Source: UniProtKB
- digestion Source: UniProtKB-KW
- proteolysis Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Biological process | Digestion |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
Reactomei | R-CFA-1442490, Collagen degradation R-CFA-1592389, Activation of Matrix Metalloproteinases R-CFA-196741, Cobalamin (Cbl, vitamin B12) transport and metabolism R-CFA-6798695, Neutrophil degranulation R-CFA-6803157, Antimicrobial peptides |
Protein family/group databases
MEROPSi | S01.120 |
Names & Taxonomyi
Protein namesi | |
Organismi | Canis lupus familiaris (Dog) (Canis familiaris) |
Taxonomic identifieri | 9615 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB
- extracellular space Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 15 | Add BLAST | 15 | |
PropeptideiPRO_0000028193 | 16 – 23 | Activation peptide | 8 | |
ChainiPRO_0000028194 | 24 – 247 | Anionic trypsinAdd BLAST | 224 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 30 ↔ 160 | PROSITE-ProRule annotation | ||
Disulfide bondi | 48 ↔ 64 | PROSITE-ProRule annotation | ||
Disulfide bondi | 132 ↔ 233 | PROSITE-ProRule annotation | ||
Disulfide bondi | 139 ↔ 206 | PROSITE-ProRule annotation | ||
Disulfide bondi | 171 ↔ 185 | PROSITE-ProRule annotation | ||
Disulfide bondi | 196 ↔ 220 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, ZymogenProteomic databases
PaxDbi | P06872 |
PRIDEi | P06872 |
Expressioni
Gene expression databases
Bgeei | ENSCAFG00000014481, Expressed in pancreas and 37 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 244 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 221 |
Sequence similaritiesi
Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3627, Eukaryota |
HOGENOMi | CLU_006842_7_0_1 |
InParanoidi | P06872 |
OMAi | HADCEAS |
OrthoDBi | 1314811at2759 |
TreeFami | TF331065 |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 3 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P06872-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNPLLILAFL GAAVATPTDD DDKIVGGYTC EENSVPYQVS LNAGYHFCGG
60 70 80 90 100
SLISDQWVVS AAHCYKSRIQ VRLGEYNIDV LEGNEQFINS AKVIRHPNYN
110 120 130 140 150
SWILDNDIML IKLSSPAVLN ARVATISLPR ACAAPGTQCL ISGWGNTLSS
160 170 180 190 200
GTNYPELLQC LDAPILTQAQ CEASYPGQIT ENMICAGFLE GGKDSCQGDS
210 220 230 240
GGPVVCNGEL QGIVSWGYGC AQKNKPGVYT KVCNFVDWIQ STIAANS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M11589 mRNA Translation: AAA30899.1 |
PIRi | A26273, TRDG |
RefSeqi | XP_003432104.1, XM_003432056.2 |
Genome annotation databases
GeneIDi | 100686744 |
KEGGi | cfa:100686744 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M11589 mRNA Translation: AAA30899.1 |
PIRi | A26273, TRDG |
RefSeqi | XP_003432104.1, XM_003432056.2 |
3D structure databases
SMRi | P06872 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9612.ENSCAFP00000021363 |
Protein family/group databases
MEROPSi | S01.120 |
Proteomic databases
PaxDbi | P06872 |
PRIDEi | P06872 |
Genome annotation databases
GeneIDi | 100686744 |
KEGGi | cfa:100686744 |
Organism-specific databases
CTDi | 5645 |
Phylogenomic databases
eggNOGi | KOG3627, Eukaryota |
HOGENOMi | CLU_006842_7_0_1 |
InParanoidi | P06872 |
OMAi | HADCEAS |
OrthoDBi | 1314811at2759 |
TreeFami | TF331065 |
Enzyme and pathway databases
Reactomei | R-CFA-1442490, Collagen degradation R-CFA-1592389, Activation of Matrix Metalloproteinases R-CFA-196741, Cobalamin (Cbl, vitamin B12) transport and metabolism R-CFA-6798695, Neutrophil degranulation R-CFA-6803157, Antimicrobial peptides |
Gene expression databases
Bgeei | ENSCAFG00000014481, Expressed in pancreas and 37 other tissues |
Family and domain databases
CDDi | cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 3 hits |
InterProi | View protein in InterPro IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER |
Pfami | View protein in Pfam PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit |
PROSITEi | View protein in PROSITE PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TRY2_CANLF | |
Accessioni | P06872Primary (citable) accession number: P06872 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | January 1, 1988 | |
Last modified: | December 2, 2020 | |
This is version 142 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families