UniProtKB - P06857 (LIPR1_CANLF)
Protein
Inactive pancreatic lipase-related protein 1
Gene
PNLIPRP1
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Functioni
May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro).
Caution
Was originally (PubMed:3562437 and PubMed:2502543) thought to be the pancreatic lipase, but has been shown to lack lipase activity.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 171 | Nucleophile | 1 | |
Active sitei | 194 | Charge relay system | 1 | |
Metal bindingi | 205 | Calcium; via carbonyl oxygen | 1 | |
Metal bindingi | 208 | Calcium; via carbonyl oxygen | 1 | |
Metal bindingi | 210 | Calcium | 1 | |
Metal bindingi | 213 | Calcium | 1 | |
Active sitei | 281 | Charge relay system | 1 |
GO - Molecular functioni
- calcium ion binding Source: UniProtKB
- carboxylic ester hydrolase activity Source: InterPro
GO - Biological processi
- lipid catabolic process Source: UniProtKB-KW
Keywordsi
Biological process | Lipid degradation, Lipid metabolism |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.1.1.26, 1153 |
Reactomei | R-CFA-192456, Digestion of dietary lipid |
Protein family/group databases
ESTHERi | canfa-1plip, Pancreatic_lipase |
Names & Taxonomyi
Protein namesi | Recommended name: Inactive pancreatic lipase-related protein 1Short name: PL-RP1 |
Gene namesi | Name:PNLIPRP1 Synonyms:PLRP1 |
Organismi | Canis lupus familiaris (Dog) (Canis familiaris) |
Taxonomic identifieri | 9615 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 196 | V → A: Removes steric hindrance and restores lipase activity; when associated with P-198. 1 Publication | 1 | |
Mutagenesisi | 198 | A → P: Removes steric hindrance and restores lipase activity; when associated with A-196. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | 1 PublicationAdd BLAST | 17 | |
ChainiPRO_0000017789 | 18 – 467 | Inactive pancreatic lipase-related protein 1Add BLAST | 450 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 21 ↔ 27 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 109 ↔ 120 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 157 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 255 ↔ 279 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 303 ↔ 314 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 317 ↔ 322 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 451 ↔ 467 | PROSITE-ProRule annotation1 Publication |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P06857 |
PTM databases
iPTMneti | P06857 |
Expressioni
Tissue specificityi
Detected in pancreas (at protein level).1 Publication
Gene expression databases
Bgeei | ENSCAFG00000011852, Expressed in pancreas and 35 other tissues |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P06857 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P06857 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 356 – 467 | PLATPROSITE-ProRule annotationAdd BLAST | 112 |
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QUK7, Eukaryota |
HOGENOMi | CLU_027171_0_2_1 |
InParanoidi | P06857 |
OMAi | KGNTHQY |
OrthoDBi | 534956at2759 |
TreeFami | TF324997 |
Family and domain databases
CDDi | cd00707, Pancreat_lipase_like, 1 hit |
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR013818, Lipase/vitellogenin IPR016272, Lipase_LIPH IPR033906, Lipase_N IPR002331, Lipase_panc IPR001024, PLAT/LH2_dom IPR036392, PLAT/LH2_dom_sf IPR000734, TAG_lipase |
PANTHERi | PTHR11610, PTHR11610, 1 hit |
Pfami | View protein in Pfam PF00151, Lipase, 1 hit PF01477, PLAT, 1 hit |
PIRSFi | PIRSF000865, Lipoprotein_lipase_LIPH, 1 hit |
PRINTSi | PR00823, PANCLIPASE PR00821, TAGLIPASE |
SMARTi | View protein in SMART SM00308, LH2, 1 hit |
SUPFAMi | SSF49723, SSF49723, 1 hit SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00120, LIPASE_SER, 1 hit PS50095, PLAT, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P06857-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVSIWTIALF LLGAAKAKEV CYEQIGCFSD AEPWAGTAIR PLKVLPWSPE
60 70 80 90 100
RIGTRFLLYT NKNPNNFQTL LPSDPSTIEA SNFQTDKKTR FIIHGFIDKG
110 120 130 140 150
EENWLLDMCK NMFKVEEVNC ICVDWKKGSQ TSYTQAANNV RVVGAQVAQM
160 170 180 190 200
LSMLSANYSY SPSQVQLIGH SLGAHVAGEA GSRTPGLGRI TGLDPVEASF
210 220 230 240 250
QGTPEEVRLD PTDADFVDVI HTDAAPLIPF LGFGTSQQMG HLDFFPNGGE
260 270 280 290 300
EMPGCKKNAL SQIVDLDGIW EGTRDFVACN HLRSYKYYSE SILNPDGFAS
310 320 330 340 350
YPCASYRAFE SNKCFPCPDQ GCPQMGHYAD KFAVKTSDET QKYFLNTGDS
360 370 380 390 400
SNFARWRYGV SITLSGKRAT GQAKVALFGS KGNTHQFNIF KGILKPGSTH
410 420 430 440 450
SNEFDAKLDV GTIEKVKFLW NNNVVNPTFP KVGAAKITVQ KGEEKTVHSF
460
CSESTVREDV LLTLTPC
Sequence cautioni
The sequence AAA30840 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 92 | I → T in AAA30885 (PubMed:3562437).Curated | 1 | |
Sequence conflicti | 98 | D → N in AAA30885 (PubMed:3562437).Curated | 1 | |
Sequence conflicti | 265 | D → N in AAA30885 (PubMed:3562437).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M35302 mRNA Translation: AAA30885.1 M28151 , M28141, M28142, M28143, M28145, M28148, M28147, M28146, M28144, M28149, M28150 Genomic DNA Translation: AAA30840.1 Sequence problems. |
PIRi | B24392, LIDG |
RefSeqi | NP_001003319.2, NM_001003319.2 |
Genome annotation databases
Ensembli | ENSCAFT00030046588; ENSCAFP00030040719; ENSCAFG00030025195 ENSCAFT00040046440; ENSCAFP00040040526; ENSCAFG00040024900 |
GeneIDi | 404010 |
KEGGi | cfa:404010 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M35302 mRNA Translation: AAA30885.1 M28151 , M28141, M28142, M28143, M28145, M28148, M28147, M28146, M28144, M28149, M28150 Genomic DNA Translation: AAA30840.1 Sequence problems. |
PIRi | B24392, LIDG |
RefSeqi | NP_001003319.2, NM_001003319.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1RP1 | X-ray | 2.10 | A | 18-467 | [»] | |
SMRi | P06857 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 9612.ENSCAFP00000017453 |
Protein family/group databases
ESTHERi | canfa-1plip, Pancreatic_lipase |
PTM databases
iPTMneti | P06857 |
Proteomic databases
PaxDbi | P06857 |
Genome annotation databases
Ensembli | ENSCAFT00030046588; ENSCAFP00030040719; ENSCAFG00030025195 ENSCAFT00040046440; ENSCAFP00040040526; ENSCAFG00040024900 |
GeneIDi | 404010 |
KEGGi | cfa:404010 |
Organism-specific databases
CTDi | 5407 |
Phylogenomic databases
eggNOGi | ENOG502QUK7, Eukaryota |
HOGENOMi | CLU_027171_0_2_1 |
InParanoidi | P06857 |
OMAi | KGNTHQY |
OrthoDBi | 534956at2759 |
TreeFami | TF324997 |
Enzyme and pathway databases
BRENDAi | 3.1.1.26, 1153 |
Reactomei | R-CFA-192456, Digestion of dietary lipid |
Miscellaneous databases
EvolutionaryTracei | P06857 |
Gene expression databases
Bgeei | ENSCAFG00000011852, Expressed in pancreas and 35 other tissues |
Family and domain databases
CDDi | cd00707, Pancreat_lipase_like, 1 hit |
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR013818, Lipase/vitellogenin IPR016272, Lipase_LIPH IPR033906, Lipase_N IPR002331, Lipase_panc IPR001024, PLAT/LH2_dom IPR036392, PLAT/LH2_dom_sf IPR000734, TAG_lipase |
PANTHERi | PTHR11610, PTHR11610, 1 hit |
Pfami | View protein in Pfam PF00151, Lipase, 1 hit PF01477, PLAT, 1 hit |
PIRSFi | PIRSF000865, Lipoprotein_lipase_LIPH, 1 hit |
PRINTSi | PR00823, PANCLIPASE PR00821, TAGLIPASE |
SMARTi | View protein in SMART SM00308, LH2, 1 hit |
SUPFAMi | SSF49723, SSF49723, 1 hit SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00120, LIPASE_SER, 1 hit PS50095, PLAT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LIPR1_CANLF | |
Accessioni | P06857Primary (citable) accession number: P06857 Secondary accession number(s): Q28287 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | November 1, 1990 | |
Last modified: | December 2, 2020 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families