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Protein

Corticoliberin

Gene

CRH

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).By similarity

GO - Molecular functioni

  • corticotropin-releasing hormone activity Source: GO_Central
  • corticotropin-releasing hormone receptor 1 binding Source: Ensembl
  • corticotropin-releasing hormone receptor 2 binding Source: Ensembl
  • hormone activity Source: ProtInc
  • neuropeptide hormone activity Source: ProtInc
  • signaling receptor binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-418555 G alpha (s) signalling events
SIGNORiP06850

Names & Taxonomyi

Protein namesi
Recommended name:
Corticoliberin
Alternative name(s):
Corticotropin-releasing factor
Short name:
CRF
Corticotropin-releasing hormone
Gene namesi
Name:CRH
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000147571.4
HGNCiHGNC:2355 CRH
MIMi122560 gene+phenotype
neXtProtiNX_P06850

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi183Q → A: Strongly reduced affinity for CRFR1. 1 Publication1
Mutagenesisi187N → A: No effect on affinity for CRFR1. 1 Publication1
Mutagenesisi188R → A: Strongly reduced affinity for CRFR1. 1 Publication1
Mutagenesisi190L → A: Strongly reduced affinity for CRFR1. 1 Publication1
Mutagenesisi191M → A: Strongly reduced affinity for CRFR1. 1 Publication1
Mutagenesisi192E → A: No effect on affinity for CRFR1. 1 Publication1

Organism-specific databases

DisGeNETi1392
GeneReviewsiCRH
MIMi122560 gene+phenotype
OpenTargetsiENSG00000147571
Orphaneti98784 Autosomal dominant nocturnal frontal lobe epilepsy
PharmGKBiPA119

Chemistry databases

DrugBankiDB02952 Alpha-Aminoisobutyric Acid
DB01285 Corticotropin
DB02556 D-Phenylalanine

Polymorphism and mutation databases

BioMutaiCRH
DMDMi117445

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24CuratedAdd BLAST24
PropeptideiPRO_000000621225 – 1531 PublicationAdd BLAST129
PeptideiPRO_0000006213154 – 194CorticoliberinAdd BLAST41

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei194Isoleucine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP06850
PeptideAtlasiP06850
PRIDEiP06850
ProteomicsDBi51935
TopDownProteomicsiP06850

PTM databases

iPTMnetiP06850
PhosphoSitePlusiP06850

Expressioni

Tissue specificityi

Produced by the hypothalamus and placenta.2 Publications

Gene expression databases

BgeeiENSG00000147571
CleanExiHS_CRH
ExpressionAtlasiP06850 baseline and differential
GenevisibleiP06850 HS

Organism-specific databases

HPAiHPA046846
HPA062111

Interactioni

Subunit structurei

Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain).1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • corticotropin-releasing hormone activity Source: GO_Central
  • corticotropin-releasing hormone receptor 1 binding Source: Ensembl
  • corticotropin-releasing hormone receptor 2 binding Source: Ensembl
  • hormone activity Source: ProtInc
  • neuropeptide hormone activity Source: ProtInc
  • signaling receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi107782, 7 interactors
IntActiP06850, 9 interactors
STRINGi9606.ENSP00000276571

Structurei

Secondary structure

1196
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi159 – 171Combined sources13
Helixi180 – 193Combined sources14

3D structure databases

ProteinModelPortaliP06850
SMRiP06850
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06850

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZK Eukaryota
ENOG4111ZIN LUCA
GeneTreeiENSGT00510000048573
HOGENOMiHOG000004762
HOVERGENiHBG001951
InParanoidiP06850
KOiK05256
OMAiREMMEMS
OrthoDBiEOG091G0QDI
PhylomeDBiP06850
TreeFamiTF332956

Family and domain databases

InterProiView protein in InterPro
IPR018446 Corticotropin-releasing_fac_CS
IPR000187 CRF
IPR003620 Urocortin_CRF
PANTHERiPTHR15035 PTHR15035, 1 hit
PfamiView protein in Pfam
PF00473 CRF, 1 hit
PRINTSiPR01612 CRFFAMILY
SMARTiView protein in SMART
SM00039 CRF, 1 hit
PROSITEiView protein in PROSITE
PS00511 CRF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06850-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLPLLVSAG VLLVALLPCP PCRALLSRGP VPGARQAPQH PQPLDFFQPP
60 70 80 90 100
PQSEQPQQPQ ARPVLLRMGE EYFLRLGNLN KSPAAPLSPA SSLLAGGSGS
110 120 130 140 150
RPSPEQATAN FFRVLLQQLL LPRRSLDSPA ALAERGARNA LGGHQEAPER
160 170 180 190
ERRSEEPPIS LDLTFHLLRE VLEMARAEQL AQQAHSNRKL MEIIGK
Length:196
Mass (Da):21,422
Last modified:January 1, 1988 - v1
Checksum:i0CCDFF05BE364E92
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07550430P → R Found in patients with autosomal dominant nocturnal frontal lobe epilepsy; unknown pathological significance; results in decreased protein levels; decreased protein secretion. 1 PublicationCorresponds to variant dbSNP:rs748404250EnsemblClinVar.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00571 Genomic DNA Translation: CAA23834.1
BT007453 mRNA Translation: AAP36121.1
AK075431 mRNA Translation: BAG52136.1
CH471068 Genomic DNA Translation: EAW86897.1
BC002599 mRNA Translation: AAH02599.1
BC011031 mRNA Translation: AAH11031.1
CCDSiCCDS6188.1
PIRiA30327
RefSeqiNP_000747.1, NM_000756.3
XP_016868579.1, XM_017013090.1
XP_016868580.1, XM_017013091.1
XP_016868581.1, XM_017013092.1
XP_016868582.1, XM_017013093.1
UniGeneiHs.75294

Genome annotation databases

EnsembliENST00000276571; ENSP00000276571; ENSG00000147571
GeneIDi1392
KEGGihsa:1392
UCSCiuc003xvy.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCRF_HUMAN
AccessioniPrimary (citable) accession number: P06850
Secondary accession number(s): B3KQS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: June 20, 2018
This is version 180 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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