Corticoliberin

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• corticotropin-releasing hormone activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• corticotropin-releasing hormone receptor 1 binding Source: Ensembl
• corticotropin-releasing hormone receptor 2 binding Source: Ensembl
• hormone activity Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "A placental clock controlling the length of human pregnancy."
    McLean M., Bisits A., Davies J., Woods R., Lowry P., Smith R.
    Nat Med 1:460-463(1995) [PubMed] [Europe PMC] [Abstract]
• neuropeptide hormone activity Source: ProtIncTraceable author statementⁱ
  • "Ligand requirements of the human corticotropin-releasing factor-binding protein."
    Sutton S.W., Behan D.P., Lahrichi S.L., Kaiser R., Corrigan A., Lowry P., Potter E., Perrin M.H., Rivier J., Vale W.W.
    Endocrinology 136:1097-1102(1995) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: ProtIncTraceable author statementⁱ
  • "Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease."
    Behan D.P., Heinrichs S.C., Troncoso J.C., Liu X.J., Kawas C.H., Ling N., De Souza E.B.
    Nature 378:284-287(1995) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• adrenal gland development Source: Ensembl
• associative learning Source: Ensembl
• cellular response to cocaine Source: Ensembl
• cellular response to dexamethasone stimulus Source: Ensembl
• chemical synaptic transmission Source: ProtIncTraceable author statementⁱ
  • "Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease."
    Behan D.P., Heinrichs S.C., Troncoso J.C., Liu X.J., Kawas C.H., Ling N., De Souza E.B.
    Nature 378:284-287(1995) [PubMed] [Europe PMC] [Abstract]
• diterpenoid metabolic process Source: Ensembl
• female pregnancy Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Amniotic fluid and umbilical cord plasma corticotropin-releasing factor (CRF), CRF-binding protein, adrenocorticotropin, and cortisol concentrations in intraamniotic infection and inflammation at term."
    Florio P., Romero R., Chaiworapongsa T., Kusanovic J.P., Torricelli M., Lowry P.J., Petraglia F.
    J Clin Endocrinol Metab 93:3604-3609(2008) [PubMed] [Europe PMC] [Abstract]
• glucocorticoid biosynthetic process Source: Ensembl
• G protein-coupled receptor signaling pathway Source: Reactome
• hormone-mediated apoptotic signaling pathway Source: Ensembl
• hypothalamus development Source: Ensembl
• inflammatory response Source: UniProtKBInferred from direct assayⁱ
  • "Amniotic fluid and umbilical cord plasma corticotropin-releasing factor (CRF), CRF-binding protein, adrenocorticotropin, and cortisol concentrations in intraamniotic infection and inflammation at term."
    Florio P., Romero R., Chaiworapongsa T., Kusanovic J.P., Torricelli M., Lowry P.J., Petraglia F.
    J Clin Endocrinol Metab 93:3604-3609(2008) [PubMed] [Europe PMC] [Abstract]
• ion homeostasis Source: Ensembl
• learning or memory Source: ProtIncTraceable author statementⁱ
  • "Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease."
    Behan D.P., Heinrichs S.C., Troncoso J.C., Liu X.J., Kawas C.H., Ling N., De Souza E.B.
    Nature 378:284-287(1995) [PubMed] [Europe PMC] [Abstract]
• locomotory exploration behavior Source: Ensembl
• long-term synaptic potentiation Source: Ensembl
• lung development Source: Ensembl
• negative regulation of cell death Source: Ensembl
• negative regulation of circadian sleep/wake cycle, REM sleep Source: BHF-UCL <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • "Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males."
    Kluge M., Schussler P., Bleninger P., Kleyer S., Uhr M., Weikel J.C., Yassouridis A., Zuber V., Steiger A.
    Psychoneuroendocrinology 33:497-506(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of epinephrine secretion Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of gene expression Source: Ensembl
• negative regulation of glucagon secretion Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of luteinizing hormone secretion Source: Ensembl
• negative regulation of norepinephrine secretion Source: Ensembl
• negative regulation of systemic arterial blood pressure Source: Ensembl
• parturition Source: ProtIncTraceable author statementⁱ
  • "A placental clock controlling the length of human pregnancy."
    McLean M., Bisits A., Davies J., Woods R., Lowry P., Smith R.
    Nat Med 1:460-463(1995) [PubMed] [Europe PMC] [Abstract]
• positive regulation of behavioral fear response Source: Ensembl
• positive regulation of calcium ion import Source: Ensembl
• positive regulation of cAMP-mediated signaling Source: Ensembl
• positive regulation of cell death Source: Ensembl
• positive regulation of cell population proliferation Source: Ensembl
• positive regulation of circadian sleep/wake cycle, wakefulness Source: BHF-UCLNon-traceable author statementⁱ
  • "Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males."
    Kluge M., Schussler P., Bleninger P., Kleyer S., Uhr M., Weikel J.C., Yassouridis A., Zuber V., Steiger A.
    Psychoneuroendocrinology 33:497-506(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of corticosterone secretion Source: Ensembl
• positive regulation of corticotropin secretion Source: UniProtKBInferred from direct assayⁱ
  • "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor."
    Hsu S.Y., Hsueh A.J.W.
    Nat. Med. 7:605-611(2001) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cortisol secretion Source: BHF-UCLInferred from direct assayⁱ
  • "Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males."
    Kluge M., Schussler P., Bleninger P., Kleyer S., Uhr M., Weikel J.C., Yassouridis A., Zuber V., Steiger A.
    Psychoneuroendocrinology 33:497-506(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of digestive system process Source: Ensembl
• positive regulation of gene expression Source: Ensembl
• positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
• positive regulation of protein phosphorylation Source: Ensembl
• regulation of NMDA receptor activity Source: UniProtKBInferred from direct assayⁱ
  • "Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons."
    Ungless M.A., Singh V., Crowder T.L., Yaka R., Ron D., Bonci A.
    Neuron 39:401-407(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of serotonin secretion Source: Ensembl
• response to corticosterone Source: Ensembl
• response to drug Source: Ensembl
• response to estrogen Source: Ensembl
• response to ethanol Source: Ensembl
• response to ether Source: Ensembl
• response to immobilization stress Source: Ensembl
• response to pain Source: Ensembl
• signal transduction Source: ProtIncTraceable author statementⁱ
  • "Ligand requirements of the human corticotropin-releasing factor-binding protein."
    Sutton S.W., Behan D.P., Lahrichi S.L., Kaiser R., Corrigan A., Lowry P., Potter E., Perrin M.H., Rivier J., Vale W.W.
    Endocrinology 136:1097-1102(1995) [PubMed] [Europe PMC] [Abstract]
• synaptic transmission, dopaminergic Source: UniProtKBInferred from direct assayⁱ
  • "Corticotropin-releasing factor requires CRF binding protein to potentiate NMDA receptors via CRF receptor 2 in dopamine neurons."
    Ungless M.A., Singh V., Crowder T.L., Yaka R., Ron D., Bonci A.
    Neuron 39:401-407(2003) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• corticotropin-releasing hormone activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• corticotropin-releasing hormone receptor 1 binding Source: Ensembl
• corticotropin-releasing hormone receptor 2 binding Source: Ensembl
• hormone activity Source: ProtIncTraceable author statementⁱ
  • "A placental clock controlling the length of human pregnancy."
    McLean M., Bisits A., Davies J., Woods R., Lowry P., Smith R.
    Nat Med 1:460-463(1995) [PubMed] [Europe PMC] [Abstract]
• neuropeptide hormone activity Source: ProtIncTraceable author statementⁱ
  • "Ligand requirements of the human corticotropin-releasing factor-binding protein."
    Sutton S.W., Behan D.P., Lahrichi S.L., Kaiser R., Corrigan A., Lowry P., Potter E., Perrin M.H., Rivier J., Vale W.W.
    Endocrinology 136:1097-1102(1995) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: ProtIncTraceable author statementⁱ
  • "Displacement of corticotropin releasing factor from its binding protein as a possible treatment for Alzheimer's disease."
    Behan D.P., Heinrichs S.C., Troncoso J.C., Liu X.J., Kawas C.H., Ling N., De Souza E.B.
    Nature 378:284-287(1995) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MRLPLLVSAG VLLVALLPCP PCRALLSRGP VPGARQAPQH PQPLDFFQPP 
        60         70         80         90        100
PQSEQPQQPQ ARPVLLRMGE EYFLRLGNLN KSPAAPLSPA SSLLAGGSGS 
       110        120        130        140        150
RPSPEQATAN FFRVLLQQLL LPRRSLDSPA ALAERGARNA LGGHQEAPER 
       160        170        180        190 
ERRSEEPPIS LDLTFHLLRE VLEMARAEQL AQQAHSNRKL MEIIGK     

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
4. SIMILARITY comments
   Index of protein domains and families
5. Human chromosome 8
   Human chromosome 8: entries, gene names and cross-references to MIM
6. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations