CRH

Functionⁱ

Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).By similarity

GO - Molecular functionⁱ

corticotropin-releasing hormone activity Source: GO_Central
corticotropin-releasing hormone receptor 1 binding Source: Ensembl
corticotropin-releasing hormone receptor 2 binding Source: Ensembl
hormone activity
Source: ProtInc
Traceable author statementⁱ
- 7585095
neuropeptide hormone activity
Source: ProtInc
Traceable author statementⁱ
- 7867564
signaling receptor binding
Source: ProtInc
Traceable author statementⁱ
- 7477348

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adrenal gland development Source: Ensembl
associative learning Source: Ensembl
cellular response to cocaine Source: Ensembl
cellular response to dexamethasone stimulus Source: Ensembl
chemical synaptic transmission
Source: ProtInc
Traceable author statementⁱ
- 7477348
diterpenoid metabolic process Source: Ensembl
female pregnancy
Source: UniProtKB
Inferred from direct assayⁱ
- 18559919
glucocorticoid biosynthetic process Source: Ensembl
G-protein coupled receptor signaling pathway Source: Reactome
hormone-mediated apoptotic signaling pathway Source: Ensembl
hypothalamus development Source: Ensembl
inflammatory response
Source: UniProtKB
Inferred from direct assayⁱ
- 18559919
ion homeostasis Source: Ensembl
learning or memory
Source: ProtInc
Traceable author statementⁱ
- 7477348
locomotory exploration behavior Source: Ensembl
long-term synaptic potentiation Source: Ensembl
lung development Source: Ensembl
negative regulation of cell death Source: Ensembl
negative regulation of circadian sleep/wake cycle, REM sleep
Source: BHF-UCL
Non-traceable author statementⁱ
- 18329818
negative regulation of epinephrine secretion Source: GO_Central
negative regulation of gene expression Source: Ensembl
negative regulation of glucagon secretion Source: GO_Central
negative regulation of luteinizing hormone secretion Source: Ensembl
negative regulation of norepinephrine secretion Source: Ensembl
negative regulation of systemic arterial blood pressure Source: Ensembl
parturition
Source: ProtInc
Traceable author statementⁱ
- 7585095
positive regulation of behavioral fear response Source: Ensembl
positive regulation of calcium ion import Source: Ensembl
positive regulation of cAMP-mediated signaling Source: Ensembl
positive regulation of cell death Source: Ensembl
positive regulation of cell proliferation Source: Ensembl
positive regulation of circadian sleep/wake cycle, wakefulness
Source: BHF-UCL
Non-traceable author statementⁱ
- 18329818
positive regulation of corticosterone secretion Source: Ensembl
positive regulation of corticotropin secretion
Source: UniProtKB
Inferred from direct assayⁱ
- 11329063
positive regulation of cortisol secretion
Source: BHF-UCL
Inferred from direct assayⁱ
- 18329818
positive regulation of digestive system process Source: Ensembl
positive regulation of gene expression Source: Ensembl
positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
positive regulation of protein phosphorylation Source: Ensembl
regulation of NMDA receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12895416
regulation of serotonin secretion Source: Ensembl
response to corticosterone Source: Ensembl
response to estrogen Source: Ensembl
response to ethanol Source: Ensembl
response to ether Source: Ensembl
response to immobilization stress Source: Ensembl
response to pain Source: Ensembl
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 7867564
synaptic transmission, dopaminergic
Source: UniProtKB
Inferred from direct assayⁱ
- 12895416

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hormone

Molecular function

Hormone

Enzyme and pathway databases

Reactomeⁱ	R-HSA-373080 Class B/2 (Secretin family receptors) R-HSA-418555 G alpha (s) signalling events
SIGNORⁱ	P06850

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Corticoliberin Alternative name(s): Corticotropin-releasing factor Short name: CRF Corticotropin-releasing hormone
Gene namesⁱ	Name:CRH
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000147571.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2355 CRH
MIMⁱ	122560 gene+phenotype
neXtProtⁱ	NX_P06850

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	183	Q → A: Strongly reduced affinity for CRFR1. 1 Publication	1
Mutagenesisⁱ	187	N → A: No effect on affinity for CRFR1. 1 Publication	1
Mutagenesisⁱ	188	R → A: Strongly reduced affinity for CRFR1. 1 Publication	1
Mutagenesisⁱ	190	L → A: Strongly reduced affinity for CRFR1. 1 Publication	1
Mutagenesisⁱ	191	M → A: Strongly reduced affinity for CRFR1. 1 Publication	1
Mutagenesisⁱ	192	E → A: No effect on affinity for CRFR1. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1392
GeneReviewsⁱ	CRH
MIMⁱ	122560 gene+phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000147571
Orphanetⁱ	98784 Autosomal dominant nocturnal frontal lobe epilepsy
PharmGKBⁱ	PA119

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB02952 Alpha-Aminoisobutyric Acid DB01285 Corticotropin DB02556 D-Phenylalanine

DrugBankⁱ

DB02952 Alpha-Aminoisobutyric Acid
DB01285 Corticotropin
DB02556 D-Phenylalanine

Polymorphism and mutation databases

BioMutaⁱ	CRH
DMDMⁱ	117445

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 24	CuratedAdd BLAST	24
PropeptideⁱPRO_0000006212	25 – 153	1 PublicationAdd BLAST	129
PeptideⁱPRO_0000006213	154 – 194	CorticoliberinAdd BLAST	41

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	194	Isoleucine amide1 Publication		1

Keywords - PTMⁱ

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbⁱ	P06850
PeptideAtlas More...PeptideAtlasⁱ	P06850
PRIDEⁱ	P06850
ProteomicsDBⁱ	51935
TopDownProteomicsⁱ	P06850

PTM databases

iPTMnetⁱ	P06850
PhosphoSitePlusⁱ	P06850

Expressionⁱ

Tissue specificityⁱ

Gene expression databases

Bgeeⁱ	ENSG00000147571 Expressed in 88 organ(s), highest expression level in chorionic villus
CleanExⁱ	HS_CRH
ExpressionAtlasⁱ	P06850 baseline and differential
Genevisibleⁱ	P06850 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA046846 HPA062111

HPAⁱ

HPA046846
HPA062111

Interactionⁱ

Subunit structureⁱ

Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain).1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CRHR1	P34998	2	EBI-3870390,EBI-3870393
KRT31	Q15323	3	EBI-3870390,EBI-948001

GO - Molecular functionⁱ

corticotropin-releasing hormone activity Source: GO_Central
corticotropin-releasing hormone receptor 1 binding Source: Ensembl
corticotropin-releasing hormone receptor 2 binding Source: Ensembl
hormone activity
Source: ProtInc
Traceable author statementⁱ
- 7585095
neuropeptide hormone activity
Source: ProtInc
Traceable author statementⁱ
- 7867564
signaling receptor binding
Source: ProtInc
Traceable author statementⁱ
- 7477348

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107782, 7 interactors
IntActⁱ	P06850, 9 interactors
STRINGⁱ	9606.ENSP00000276571

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	159 – 171	Combined sources		13
Helixⁱ	180 – 193	Combined sources		14

Show more details

3D structure databases

ProteinModelPortalⁱ	P06850
SMRⁱ	P06850
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P06850

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IWZK Eukaryota ENOG4111ZIN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048573
HOGENOMⁱ	HOG000004762
HOVERGENⁱ	HBG001951
InParanoidⁱ	P06850
KEGG Orthology (KO) More...KOⁱ	K05256
OMAⁱ	REMMEMS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0QDI
PhylomeDBⁱ	P06850
TreeFamⁱ	TF332956

Family and domain databases

InterProⁱ	View protein in InterPro IPR018446 Corticotropin-releasing_fac_CS IPR000187 CRF IPR003620 Urocortin_CRF
PANTHERⁱ	PTHR15035 PTHR15035, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00473 CRF, 1 hit
PRINTSⁱ	PR01612 CRFFAMILY
SMARTⁱ	View protein in SMART SM00039 CRF, 1 hit
PROSITEⁱ	View protein in PROSITE PS00511 CRF, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P06850-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRLPLLVSAG VLLVALLPCP PCRALLSRGP VPGARQAPQH PQPLDFFQPP 
        60         70         80         90        100
PQSEQPQQPQ ARPVLLRMGE EYFLRLGNLN KSPAAPLSPA SSLLAGGSGS 
       110        120        130        140        150
RPSPEQATAN FFRVLLQQLL LPRRSLDSPA ALAERGARNA LGGHQEAPER 
       160        170        180        190 
ERRSEEPPIS LDLTFHLLRE VLEMARAEQL AQQAHSNRKL MEIIGK

Length:196

Mass (Da):21,422

Last modified:January 1, 1988 - v1

Checksum:ⁱ0CCDFF05BE364E92

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_075504	30	P → R Found in patients with autosomal dominant nocturnal frontal lobe epilepsy; unknown pathological significance; results in decreased protein levels; decreased protein secretion. 1 PublicationCorresponds to variant dbSNP:rs748404250EnsemblClinVar.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	V00571 Genomic DNA Translation: CAA23834.1 BT007453 mRNA Translation: AAP36121.1 AK075431 mRNA Translation: BAG52136.1 CH471068 Genomic DNA Translation: EAW86897.1 BC002599 mRNA Translation: AAH02599.1 BC011031 mRNA Translation: AAH11031.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6188.1
PIRⁱ	A30327
NCBI Reference Sequences More...RefSeqⁱ	NP_000747.1, NM_000756.3 XP_016868579.1, XM_017013090.1 XP_016868580.1, XM_017013091.1 XP_016868581.1, XM_017013092.1 XP_016868582.1, XM_017013093.1
UniGeneⁱ	Hs.75294

Genome annotation databases

Ensemblⁱ	ENST00000276571; ENSP00000276571; ENSG00000147571
GeneIDⁱ	1392
KEGGⁱ	hsa:1392
UCSC genome browser More...UCSCⁱ	uc003xvy.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P06850	Corticotropin releasing hormone isoform 1 (Fragment)		HUMAN		196	UniRef100_P06850
CRH isoform 1		PANTR		196
Corticotropin releasing hormone		PANPA		196

Protein	Similar proteins		Species	Score	Length	Source
P06850	Corticotropin releasing hormone isoform 1 (Fragment)		HUMAN		196	UniRef90_P06850
CRH isoform 1		PANTR		196
Corticotropin releasing hormone		PANPA		196
Corticotropin releasing hormone		COLAP		200
CRH isoform 1		PONAB		199
+20

Protein	Similar proteins		Species	Score	Length	Source
P06850	Corticoliberin		RAT		187	UniRef50_P01143
Corticoliberin		MOUSE		187
Corticoliberin		PIG		191
Corticoliberin		SHEEP		190
Corticoliberin		BOVIN		190
+116

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Corticotropin-releasing hormone entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	V00571 Genomic DNA Translation: CAA23834.1 BT007453 mRNA Translation: AAP36121.1 AK075431 mRNA Translation: BAG52136.1 CH471068 Genomic DNA Translation: EAW86897.1 BC002599 mRNA Translation: AAH02599.1 BC011031 mRNA Translation: AAH11031.1
CCDSⁱ	CCDS6188.1
PIRⁱ	A30327
RefSeqⁱ	NP_000747.1, NM_000756.3 XP_016868579.1, XM_017013090.1 XP_016868580.1, XM_017013091.1 XP_016868581.1, XM_017013092.1 XP_016868582.1, XM_017013093.1
UniGeneⁱ	Hs.75294

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1GO9	NMR	-	A	154-194	[»]
	1GOE	NMR	-	A	154-194	[»]
	3EHT	X-ray	3.40	B	180-194	[»]
	3EHU	X-ray	1.96	C/D	175-194	[»]
ProteinModelPortalⁱ	P06850
SMRⁱ	P06850
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107782, 7 interactors
IntActⁱ	P06850, 9 interactors
STRINGⁱ	9606.ENSP00000276571

Chemistry databases

DrugBankⁱ	DB02952 Alpha-Aminoisobutyric Acid DB01285 Corticotropin DB02556 D-Phenylalanine

DrugBankⁱ

DB02952 Alpha-Aminoisobutyric Acid
DB01285 Corticotropin
DB02556 D-Phenylalanine

PTM databases

iPTMnetⁱ	P06850
PhosphoSitePlusⁱ	P06850

Polymorphism and mutation databases

BioMutaⁱ	CRH
DMDMⁱ	117445

Proteomic databases

PaxDbⁱ	P06850
PeptideAtlasⁱ	P06850
PRIDEⁱ	P06850
ProteomicsDBⁱ	51935
TopDownProteomicsⁱ	P06850

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1392
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000276571; ENSP00000276571; ENSG00000147571
GeneIDⁱ	1392
KEGGⁱ	hsa:1392
UCSCⁱ	uc003xvy.3 human

Organism-specific databases

CTDⁱ	1392
DisGeNETⁱ	1392
EuPathDBⁱ	HostDB:ENSG00000147571.4
GeneCardsⁱ	CRH
GeneReviewsⁱ	CRH
HGNCⁱ	HGNC:2355 CRH
HPAⁱ	HPA046846 HPA062111
MIMⁱ	122560 gene+phenotype
neXtProtⁱ	NX_P06850
OpenTargetsⁱ	ENSG00000147571
Orphanetⁱ	98784 Autosomal dominant nocturnal frontal lobe epilepsy
PharmGKBⁱ	PA119
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IWZK Eukaryota ENOG4111ZIN LUCA
GeneTreeⁱ	ENSGT00510000048573
HOGENOMⁱ	HOG000004762
HOVERGENⁱ	HBG001951
InParanoidⁱ	P06850
KOⁱ	K05256
OMAⁱ	REMMEMS
OrthoDBⁱ	EOG091G0QDI
PhylomeDBⁱ	P06850
TreeFamⁱ	TF332956

Enzyme and pathway databases

Reactomeⁱ	R-HSA-373080 Class B/2 (Secretin family receptors) R-HSA-418555 G alpha (s) signalling events
SIGNORⁱ	P06850

Miscellaneous databases

EvolutionaryTraceⁱ	P06850
GeneWikiⁱ	Corticotropin-releasing_hormone
GenomeRNAiⁱ	1392
Protein Ontology More...PROⁱ	PR:P06850
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000147571 Expressed in 88 organ(s), highest expression level in chorionic villus
CleanExⁱ	HS_CRH
ExpressionAtlasⁱ	P06850 baseline and differential
Genevisibleⁱ	P06850 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR018446 Corticotropin-releasing_fac_CS IPR000187 CRF IPR003620 Urocortin_CRF
PANTHERⁱ	PTHR15035 PTHR15035, 1 hit
Pfamⁱ	View protein in Pfam PF00473 CRF, 1 hit
PRINTSⁱ	PR01612 CRFFAMILY
SMARTⁱ	View protein in SMART SM00039 CRF, 1 hit
PROSITEⁱ	View protein in PROSITE PS00511 CRF, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CRF_HUMAN
Accessionⁱ	P06850Primary (citable) accession number: P06850 Secondary accession number(s): B3KQS4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
	Last sequence update:	January 1, 1988
	Last modified:	September 12, 2018
	This is version 181 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P06850 (CRF_HUMAN)

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Corticoliberin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ