UniProtKB - P06850 (CRF_HUMAN)
Protein
Corticoliberin
Gene
CRH
Organism
Homo sapiens (Human)
Status
Functioni
Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity).By similarity
GO - Molecular functioni
- corticotropin-releasing hormone activity Source: GO_Central
- corticotropin-releasing hormone receptor 1 binding Source: Ensembl
- corticotropin-releasing hormone receptor 2 binding Source: Ensembl
- hormone activity Source: ProtInc
- neuropeptide hormone activity Source: ProtInc
- signaling receptor binding Source: ProtInc
GO - Biological processi
- adrenal gland development Source: Ensembl
- associative learning Source: Ensembl
- cellular response to cocaine Source: Ensembl
- cellular response to dexamethasone stimulus Source: Ensembl
- chemical synaptic transmission Source: ProtInc
- diterpenoid metabolic process Source: Ensembl
- female pregnancy Source: UniProtKB
- glucocorticoid biosynthetic process Source: Ensembl
- G protein-coupled receptor signaling pathway Source: Reactome
- hormone-mediated apoptotic signaling pathway Source: Ensembl
- hypothalamus development Source: Ensembl
- inflammatory response Source: UniProtKB
- ion homeostasis Source: Ensembl
- learning or memory Source: ProtInc
- locomotory exploration behavior Source: Ensembl
- long-term synaptic potentiation Source: Ensembl
- lung development Source: Ensembl
- negative regulation of cell death Source: Ensembl
- negative regulation of circadian sleep/wake cycle, REM sleep Source: BHF-UCL
- negative regulation of epinephrine secretion Source: GO_Central
- negative regulation of gene expression Source: Ensembl
- negative regulation of glucagon secretion Source: GO_Central
- negative regulation of luteinizing hormone secretion Source: Ensembl
- negative regulation of norepinephrine secretion Source: Ensembl
- negative regulation of systemic arterial blood pressure Source: Ensembl
- parturition Source: ProtInc
- positive regulation of behavioral fear response Source: Ensembl
- positive regulation of calcium ion import Source: Ensembl
- positive regulation of cAMP-mediated signaling Source: Ensembl
- positive regulation of cell death Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of circadian sleep/wake cycle, wakefulness Source: BHF-UCL
- positive regulation of corticosterone secretion Source: Ensembl
- positive regulation of corticotropin secretion Source: UniProtKB
- positive regulation of cortisol secretion Source: BHF-UCL
- positive regulation of digestive system process Source: Ensembl
- positive regulation of gene expression Source: Ensembl
- positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
- positive regulation of protein phosphorylation Source: Ensembl
- regulation of NMDA receptor activity Source: UniProtKB
- regulation of serotonin secretion Source: Ensembl
- response to corticosterone Source: Ensembl
- response to drug Source: Ensembl
- response to estrogen Source: Ensembl
- response to ethanol Source: Ensembl
- response to ether Source: Ensembl
- response to immobilization stress Source: Ensembl
- response to pain Source: Ensembl
- signal transduction Source: ProtInc
- synaptic transmission, dopaminergic Source: UniProtKB
Keywordsi
Molecular function | Hormone |
Enzyme and pathway databases
PathwayCommonsi | P06850 |
Reactomei | R-HSA-373080, Class B/2 (Secretin family receptors) R-HSA-418555, G alpha (s) signalling events R-HSA-9022702, MECP2 regulates transcription of neuronal ligands R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SIGNORi | P06850 |
Names & Taxonomyi
Protein namesi | Recommended name: CorticoliberinAlternative name(s): Corticotropin-releasing factor Short name: CRF Corticotropin-releasing hormone |
Gene namesi | Name:CRH |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000147571.4 |
HGNCi | HGNC:2355, CRH |
MIMi | 122560, gene+phenotype |
neXtProti | NX_P06850 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Other locations
- cytoplasm Source: Ensembl
- perikaryon Source: Ensembl
- synapse Source: GOC
- varicosity Source: Ensembl
Keywords - Cellular componenti
SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 183 | Q → A: Strongly reduced affinity for CRFR1. 1 Publication | 1 | |
Mutagenesisi | 187 | N → A: No effect on affinity for CRFR1. 1 Publication | 1 | |
Mutagenesisi | 188 | R → A: Strongly reduced affinity for CRFR1. 1 Publication | 1 | |
Mutagenesisi | 190 | L → A: Strongly reduced affinity for CRFR1. 1 Publication | 1 | |
Mutagenesisi | 191 | M → A: Strongly reduced affinity for CRFR1. 1 Publication | 1 | |
Mutagenesisi | 192 | E → A: No effect on affinity for CRFR1. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 1392 |
GeneReviewsi | CRH |
MalaCardsi | CRH |
MIMi | 122560, gene+phenotype |
OpenTargetsi | ENSG00000147571 |
Orphaneti | 98784, Autosomal dominant nocturnal frontal lobe epilepsy |
PharmGKBi | PA119 |
Miscellaneous databases
Pharosi | P06850, Tbio |
Chemistry databases
DrugBanki | DB02952, 2-aminoisobutyric acid DB01285, Corticotropin DB02556, D-Phenylalanine |
Polymorphism and mutation databases
BioMutai | CRH |
DMDMi | 117445 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | CuratedAdd BLAST | 24 | |
PropeptideiPRO_0000006212 | 25 – 153 | 1 PublicationAdd BLAST | 129 | |
PeptideiPRO_0000006213 | 154 – 194 | CorticoliberinAdd BLAST | 41 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 194 | Isoleucine amide1 Publication | 1 |
Keywords - PTMi
Amidation, Cleavage on pair of basic residuesProteomic databases
MassIVEi | P06850 |
PaxDbi | P06850 |
PeptideAtlasi | P06850 |
PRIDEi | P06850 |
ProteomicsDBi | 51935 |
TopDownProteomicsi | P06850 |
PTM databases
iPTMneti | P06850 |
PhosphoSitePlusi | P06850 |
Expressioni
Tissue specificityi
Produced by the hypothalamus and placenta.2 Publications
Gene expression databases
Bgeei | ENSG00000147571, Expressed in chorionic villus and 102 other tissues |
ExpressionAtlasi | P06850, baseline and differential |
Genevisiblei | P06850, HS |
Organism-specific databases
HPAi | ENSG00000147571, Tissue enriched (placenta) |
Interactioni
Subunit structurei
Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain).
1 PublicationBinary interactionsi
Hide detailsP06850
GO - Molecular functioni
- corticotropin-releasing hormone activity Source: GO_Central
- corticotropin-releasing hormone receptor 1 binding Source: Ensembl
- corticotropin-releasing hormone receptor 2 binding Source: Ensembl
- hormone activity Source: ProtInc
- neuropeptide hormone activity Source: ProtInc
- signaling receptor binding Source: ProtInc
Protein-protein interaction databases
BioGRIDi | 107782, 16 interactors |
IntActi | P06850, 11 interactors |
STRINGi | 9606.ENSP00000276571 |
Miscellaneous databases
RNActi | P06850, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P06850 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P06850 |
Family & Domainsi
Sequence similaritiesi
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S25G, Eukaryota |
GeneTreei | ENSGT00940000154473 |
HOGENOMi | CLU_136288_0_0_1 |
InParanoidi | P06850 |
OMAi | HNNRKLM |
OrthoDBi | 1532326at2759 |
PhylomeDBi | P06850 |
TreeFami | TF332956 |
Family and domain databases
InterProi | View protein in InterPro IPR018446, Corticotropin-releasing_fac_CS IPR000187, CRF IPR003620, Urocortin_CRF |
PANTHERi | PTHR15035, PTHR15035, 1 hit |
Pfami | View protein in Pfam PF00473, CRF, 1 hit |
PRINTSi | PR01612, CRFFAMILY |
SMARTi | View protein in SMART SM00039, CRF, 1 hit |
PROSITEi | View protein in PROSITE PS00511, CRF, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P06850-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLPLLVSAG VLLVALLPCP PCRALLSRGP VPGARQAPQH PQPLDFFQPP
60 70 80 90 100
PQSEQPQQPQ ARPVLLRMGE EYFLRLGNLN KSPAAPLSPA SSLLAGGSGS
110 120 130 140 150
RPSPEQATAN FFRVLLQQLL LPRRSLDSPA ALAERGARNA LGGHQEAPER
160 170 180 190
ERRSEEPPIS LDLTFHLLRE VLEMARAEQL AQQAHSNRKL MEIIGK
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_075504 | 30 | P → R Found in patients with autosomal dominant nocturnal frontal lobe epilepsy; unknown pathological significance; results in decreased protein levels; decreased protein secretion. 1 PublicationCorresponds to variant dbSNP:rs748404250EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00571 Genomic DNA Translation: CAA23834.1 BT007453 mRNA Translation: AAP36121.1 AK075431 mRNA Translation: BAG52136.1 CH471068 Genomic DNA Translation: EAW86897.1 BC002599 mRNA Translation: AAH02599.1 BC011031 mRNA Translation: AAH11031.1 |
CCDSi | CCDS6188.1 |
PIRi | A30327 |
RefSeqi | NP_000747.1, NM_000756.3 XP_016868579.1, XM_017013090.1 XP_016868580.1, XM_017013091.1 XP_016868581.1, XM_017013092.1 XP_016868582.1, XM_017013093.1 |
Genome annotation databases
Ensembli | ENST00000276571; ENSP00000276571; ENSG00000147571 |
GeneIDi | 1392 |
KEGGi | hsa:1392 |
UCSCi | uc003xvy.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Corticotropin-releasing hormone entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00571 Genomic DNA Translation: CAA23834.1 BT007453 mRNA Translation: AAP36121.1 AK075431 mRNA Translation: BAG52136.1 CH471068 Genomic DNA Translation: EAW86897.1 BC002599 mRNA Translation: AAH02599.1 BC011031 mRNA Translation: AAH11031.1 |
CCDSi | CCDS6188.1 |
PIRi | A30327 |
RefSeqi | NP_000747.1, NM_000756.3 XP_016868579.1, XM_017013090.1 XP_016868580.1, XM_017013091.1 XP_016868581.1, XM_017013092.1 XP_016868582.1, XM_017013093.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1GO9 | NMR | - | A | 154-194 | [»] | |
1GOE | NMR | - | A | 154-194 | [»] | |
3EHT | X-ray | 3.40 | B | 180-194 | [»] | |
3EHU | X-ray | 1.96 | C/D | 175-194 | [»] | |
6P9X | electron microscopy | 2.91 | P | 154-194 | [»] | |
SMRi | P06850 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107782, 16 interactors |
IntActi | P06850, 11 interactors |
STRINGi | 9606.ENSP00000276571 |
Chemistry databases
DrugBanki | DB02952, 2-aminoisobutyric acid DB01285, Corticotropin DB02556, D-Phenylalanine |
PTM databases
iPTMneti | P06850 |
PhosphoSitePlusi | P06850 |
Polymorphism and mutation databases
BioMutai | CRH |
DMDMi | 117445 |
Proteomic databases
MassIVEi | P06850 |
PaxDbi | P06850 |
PeptideAtlasi | P06850 |
PRIDEi | P06850 |
ProteomicsDBi | 51935 |
TopDownProteomicsi | P06850 |
Protocols and materials databases
Antibodypediai | 11984, 525 antibodies |
DNASUi | 1392 |
Genome annotation databases
Ensembli | ENST00000276571; ENSP00000276571; ENSG00000147571 |
GeneIDi | 1392 |
KEGGi | hsa:1392 |
UCSCi | uc003xvy.3, human |
Organism-specific databases
CTDi | 1392 |
DisGeNETi | 1392 |
EuPathDBi | HostDB:ENSG00000147571.4 |
GeneCardsi | CRH |
GeneReviewsi | CRH |
HGNCi | HGNC:2355, CRH |
HPAi | ENSG00000147571, Tissue enriched (placenta) |
MalaCardsi | CRH |
MIMi | 122560, gene+phenotype |
neXtProti | NX_P06850 |
OpenTargetsi | ENSG00000147571 |
Orphaneti | 98784, Autosomal dominant nocturnal frontal lobe epilepsy |
PharmGKBi | PA119 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S25G, Eukaryota |
GeneTreei | ENSGT00940000154473 |
HOGENOMi | CLU_136288_0_0_1 |
InParanoidi | P06850 |
OMAi | HNNRKLM |
OrthoDBi | 1532326at2759 |
PhylomeDBi | P06850 |
TreeFami | TF332956 |
Enzyme and pathway databases
PathwayCommonsi | P06850 |
Reactomei | R-HSA-373080, Class B/2 (Secretin family receptors) R-HSA-418555, G alpha (s) signalling events R-HSA-9022702, MECP2 regulates transcription of neuronal ligands R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production |
SIGNORi | P06850 |
Miscellaneous databases
BioGRID-ORCSi | 1392, 9 hits in 842 CRISPR screens |
EvolutionaryTracei | P06850 |
GeneWikii | Corticotropin-releasing_hormone |
GenomeRNAii | 1392 |
Pharosi | P06850, Tbio |
PROi | PR:P06850 |
RNActi | P06850, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000147571, Expressed in chorionic villus and 102 other tissues |
ExpressionAtlasi | P06850, baseline and differential |
Genevisiblei | P06850, HS |
Family and domain databases
InterProi | View protein in InterPro IPR018446, Corticotropin-releasing_fac_CS IPR000187, CRF IPR003620, Urocortin_CRF |
PANTHERi | PTHR15035, PTHR15035, 1 hit |
Pfami | View protein in Pfam PF00473, CRF, 1 hit |
PRINTSi | PR01612, CRFFAMILY |
SMARTi | View protein in SMART SM00039, CRF, 1 hit |
PROSITEi | View protein in PROSITE PS00511, CRF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CRF_HUMAN | |
Accessioni | P06850Primary (citable) accession number: P06850 Secondary accession number(s): B3KQS4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | January 1, 1988 | |
Last modified: | December 2, 2020 | |
This is version 197 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations