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Protein

DNA repair protein RAD10

Gene

RAD10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Along with RAD1 forms an endonuclease that specifically degrades single-stranded DNA.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi133 – 153Sequence analysisAdd BLAST21

GO - Molecular functioni

  • damaged DNA binding Source: GO_Central
  • single-stranded DNA binding Source: SGD
  • single-stranded DNA endodeoxyribonuclease activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Endonuclease, Hydrolase, Nuclease
Biological processDNA damage, DNA repair

Enzyme and pathway databases

BioCyciYEAST:G3O-32680-MONOMER
ReactomeiR-SCE-5696395 Formation of Incision Complex in GG-NER
R-SCE-5696400 Dual Incision in GG-NER
R-SCE-6782135 Dual incision in TC-NER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein RAD10
Gene namesi
Name:RAD10
Ordered Locus Names:YML095C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

SGDiS000004560 RAD10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000971491 – 210DNA repair protein RAD10Add BLAST210

Proteomic databases

MaxQBiP06838
PaxDbiP06838
PRIDEiP06838

Interactioni

Subunit structurei

Component of the nucleotide excision repair factor 1 (NEF1) complex consisting of RAD1, RAD10 and RAD14. Interacts with SAW1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
RAD1P0677711EBI-14637,EBI-14752

Protein-protein interaction databases

BioGridi35048, 155 interactors
ComplexPortaliCPX-1362 SLX4-RAD1-RAD10 endonuclease complex
CPX-1363 SAW1-RAD1-RAD10 endonuclease complex
CPX-1708 Nucleotide-excision repair factor 1 complex
DIPiDIP-1545N
IntActiP06838, 24 interactors
MINTiP06838
STRINGi4932.YML095C

Structurei

3D structure databases

ProteinModelPortaliP06838
SMRiP06838
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi17 – 23Nuclear localization signalSequence analysis7

Sequence similaritiesi

Belongs to the ERCC1/RAD10/SWI10 family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000011275
HOGENOMiHOG000000743
InParanoidiP06838
KOiK10849
OMAiWRYVSST
OrthoDBiEOG092C4HDL

Family and domain databases

InterProiView protein in InterPro
IPR004579 ERCC1/RAD10/SWI10
IPR011335 Restrct_endonuc-II-like
PANTHERiPTHR12749 PTHR12749, 1 hit
PfamiView protein in Pfam
PF03834 Rad10, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD013585 DNA_repair_Rad10, 1 hit
SUPFAMiSSF52980 SSF52980, 1 hit
TIGRFAMsiTIGR00597 rad10, 1 hit

Sequencei

Sequence statusi: Complete.

P06838-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNNTDPTSFE SILAGVAKLR KEKSGADTTG SQSLEIDASK LQQQEPQTSR
60 70 80 90 100
RINSNQVINA FNQQKPEEWT DSKATDDYNR KRPFRSTRPG KTVLVNTTQK
110 120 130 140 150
ENPLLNHLKS TNWRYVSSTG INMIYYDYLV RGRSVLFLTL TYHKLYVDYI
160 170 180 190 200
SRRMQPLSRN ENNILIFIVD DNNSEDTLND ITKLCMFNGF TLLLAFNFEQ
210
AAKYIEYLNL
Length:210
Mass (Da):24,311
Last modified:January 1, 1988 - v1
Checksum:i26891AD9CA1E3E2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02591 Genomic DNA Translation: CAA26433.1
X05225 Genomic DNA Translation: CAA28856.1
Z46660 Genomic DNA Translation: CAA86642.1
BK006946 Genomic DNA Translation: DAA09804.1
PIRiA24576
RefSeqiNP_013614.1, NM_001182454.1

Genome annotation databases

EnsemblFungiiYML095C; YML095C; YML095C
GeneIDi854878
KEGGisce:YML095C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02591 Genomic DNA Translation: CAA26433.1
X05225 Genomic DNA Translation: CAA28856.1
Z46660 Genomic DNA Translation: CAA86642.1
BK006946 Genomic DNA Translation: DAA09804.1
PIRiA24576
RefSeqiNP_013614.1, NM_001182454.1

3D structure databases

ProteinModelPortaliP06838
SMRiP06838
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35048, 155 interactors
ComplexPortaliCPX-1362 SLX4-RAD1-RAD10 endonuclease complex
CPX-1363 SAW1-RAD1-RAD10 endonuclease complex
CPX-1708 Nucleotide-excision repair factor 1 complex
DIPiDIP-1545N
IntActiP06838, 24 interactors
MINTiP06838
STRINGi4932.YML095C

Proteomic databases

MaxQBiP06838
PaxDbiP06838
PRIDEiP06838

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYML095C; YML095C; YML095C
GeneIDi854878
KEGGisce:YML095C

Organism-specific databases

SGDiS000004560 RAD10

Phylogenomic databases

GeneTreeiENSGT00390000011275
HOGENOMiHOG000000743
InParanoidiP06838
KOiK10849
OMAiWRYVSST
OrthoDBiEOG092C4HDL

Enzyme and pathway databases

BioCyciYEAST:G3O-32680-MONOMER
ReactomeiR-SCE-5696395 Formation of Incision Complex in GG-NER
R-SCE-5696400 Dual Incision in GG-NER
R-SCE-6782135 Dual incision in TC-NER

Miscellaneous databases

PROiPR:P06838

Family and domain databases

InterProiView protein in InterPro
IPR004579 ERCC1/RAD10/SWI10
IPR011335 Restrct_endonuc-II-like
PANTHERiPTHR12749 PTHR12749, 1 hit
PfamiView protein in Pfam
PF03834 Rad10, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD013585 DNA_repair_Rad10, 1 hit
SUPFAMiSSF52980 SSF52980, 1 hit
TIGRFAMsiTIGR00597 rad10, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAD10_YEAST
AccessioniPrimary (citable) accession number: P06838
Secondary accession number(s): D6W0J0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 7, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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Main funding by: National Institutes of Health

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