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Protein

Neuromodulin

Gene

Gap43

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding, Developmental protein
Biological processDifferentiation, Growth regulation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-MMU-373760 L1CAM interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromodulin
Alternative name(s):
Axonal membrane protein GAP-43
Calmodulin-binding protein P-57
Growth-associated protein 43
Gene namesi
Name:Gap43
Synonyms:Basp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:95639 Gap43

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001595971 – 227NeuromodulinAdd BLAST227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi3S-palmitoyl cysteineBy similarity1
Lipidationi4S-palmitoyl cysteineBy similarity1
Modified residuei41Phosphoserine; by PHKBy similarityCurated1
Modified residuei86PhosphoserineCombined sources1
Modified residuei96PhosphoserineCombined sources1
Modified residuei138PhosphothreonineCombined sources1
Modified residuei142PhosphoserineCombined sources1
Modified residuei144PhosphoserineCombined sources1
Modified residuei145PhosphoserineCombined sources1
Modified residuei172PhosphothreonineCombined sources1
Modified residuei192Phosphoserine; by CK2By similarity1
Modified residuei193Phosphoserine; by CK2By similarity1

Post-translational modificationi

Palmitoylation by ARF6 is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2 (By similarity).By similarity
Phosphorylated at Ser-41 by PHK. Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity.

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP06837
PaxDbiP06837
PeptideAtlasiP06837
PRIDEiP06837

PTM databases

iPTMnetiP06837
PhosphoSitePlusiP06837
SwissPalmiP06837

Expressioni

Gene expression databases

BgeeiENSMUSG00000047261 Expressed in 272 organ(s), highest expression level in forebrain
CleanExiMM_GAP43
GenevisibleiP06837 MM

Interactioni

Subunit structurei

Binds calmodulin with a greater affinity in the absence of Ca2+ than in its presence (By similarity). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199828, 2 interactors
CORUMiP06837
IntActiP06837, 5 interactors
MINTiP06837
STRINGi10090.ENSMUSP00000099881

Structurei

Secondary structure

1227
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP06837
SMRiP06837
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 60IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 4Important for membrane binding4

Sequence similaritiesi

Belongs to the neuromodulin family.Curated

Phylogenomic databases

eggNOGiENOG410IVZP Eukaryota
ENOG411256P LUCA
GeneTreeiENSGT00730000111265
HOGENOMiHOG000013014
HOVERGENiHBG006468
InParanoidiP06837
KOiK20041
OMAiIPLHALD
OrthoDBiEOG091G0Z3Z
PhylomeDBiP06837
TreeFamiTF333213

Family and domain databases

InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR001422 Neuromodulin
IPR017454 Neuromodulin_C
IPR018947 Neuromodulin_gap-junction_N
IPR033137 Neuromodulin_P_site
IPR018243 Neuromodulin_palmitoyl_site
PfamiView protein in Pfam
PF00612 IQ, 1 hit
PF06614 Neuromodulin, 1 hit
PF10580 Neuromodulin_N, 1 hit
PRINTSiPR00215 NEUROMODULIN
SMARTiView protein in SMART
SM00015 IQ, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS00412 NEUROMODULIN_1, 1 hit
PS00413 NEUROMODULIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

P06837-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLCCMRRTKQ VEKNDEDQKI EQDGVKPEDK AHKAATKIQA SFRGHITRKK
60 70 80 90 100
LKGEKKGDAP AAEAEAKEKD DAPVADGVEK KEGDGSATTD AAPATSPKAE
110 120 130 140 150
EPSKAGDAPS EEKKGEGDAA PSEEKAGSAE TESAAKATTD NSPSSKAEDG
160 170 180 190 200
PAKEEPKQAD VPAAVTDAAA TTPAAEDAAT KAAQPPTETA ESSQAEEEKD
210 220
AVDEAKPKES ARQDEGKEDP EADQEHA
Length:227
Mass (Da):23,632
Last modified:January 1, 1988 - v1
Checksum:i14803B2F8F0649F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02809 mRNA Translation: AAA37377.1
BC028288 mRNA Translation: AAH28288.1
BC080758 mRNA Translation: AAH80758.1
CCDSiCCDS28177.1
PIRiA29800
RefSeqiNP_032109.1, NM_008083.2
UniGeneiMm.1222

Genome annotation databases

EnsembliENSMUST00000102817; ENSMUSP00000099881; ENSMUSG00000047261
GeneIDi14432
KEGGimmu:14432
UCSCiuc007zfv.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02809 mRNA Translation: AAA37377.1
BC028288 mRNA Translation: AAH28288.1
BC080758 mRNA Translation: AAH80758.1
CCDSiCCDS28177.1
PIRiA29800
RefSeqiNP_032109.1, NM_008083.2
UniGeneiMm.1222

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4E53X-ray2.69A/B34-57[»]
ProteinModelPortaliP06837
SMRiP06837
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199828, 2 interactors
CORUMiP06837
IntActiP06837, 5 interactors
MINTiP06837
STRINGi10090.ENSMUSP00000099881

PTM databases

iPTMnetiP06837
PhosphoSitePlusiP06837
SwissPalmiP06837

Proteomic databases

MaxQBiP06837
PaxDbiP06837
PeptideAtlasiP06837
PRIDEiP06837

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102817; ENSMUSP00000099881; ENSMUSG00000047261
GeneIDi14432
KEGGimmu:14432
UCSCiuc007zfv.1 mouse

Organism-specific databases

CTDi2596
MGIiMGI:95639 Gap43

Phylogenomic databases

eggNOGiENOG410IVZP Eukaryota
ENOG411256P LUCA
GeneTreeiENSGT00730000111265
HOGENOMiHOG000013014
HOVERGENiHBG006468
InParanoidiP06837
KOiK20041
OMAiIPLHALD
OrthoDBiEOG091G0Z3Z
PhylomeDBiP06837
TreeFamiTF333213

Enzyme and pathway databases

ReactomeiR-MMU-373760 L1CAM interactions

Miscellaneous databases

ChiTaRSiGap43 mouse
PROiPR:P06837
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047261 Expressed in 272 organ(s), highest expression level in forebrain
CleanExiMM_GAP43
GenevisibleiP06837 MM

Family and domain databases

InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR001422 Neuromodulin
IPR017454 Neuromodulin_C
IPR018947 Neuromodulin_gap-junction_N
IPR033137 Neuromodulin_P_site
IPR018243 Neuromodulin_palmitoyl_site
PfamiView protein in Pfam
PF00612 IQ, 1 hit
PF06614 Neuromodulin, 1 hit
PF10580 Neuromodulin_N, 1 hit
PRINTSiPR00215 NEUROMODULIN
SMARTiView protein in SMART
SM00015 IQ, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS00412 NEUROMODULIN_1, 1 hit
PS00413 NEUROMODULIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNEUM_MOUSE
AccessioniPrimary (citable) accession number: P06837
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 7, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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