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Protein

Prohead core protein protease

Gene

21

Organism
Enterobacteria phage T4 (Bacteriophage T4)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The pathway of bacteriophage T4 head assembly begins with the formation of a prohead bound to the bacterial cell membrane which is later converted to the mature, DNA-containing head. During maturation, all but one of the prohead proteins are proteolytically processed by a phage-coded protease which is formed by autocatalytic cleavage of the product of gene 21 (gp21). Protease gp21 has been tentatively located in the center of the prohead core.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease
Biological processViral capsid assembly, Viral capsid maturation, Viral release from host cell

Protein family/group databases

MEROPSiS77.001

Names & Taxonomyi

Protein namesi
Recommended name:
Prohead core protein protease (EC:3.4.99.-)
Alternative name(s):
Protein Gp21
Gene namesi
Name:21
OrganismiEnterobacteria phage T4 (Bacteriophage T4)
Taxonomic identifieri10665 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaeTevenvirinaeT4virus
Virus hostiEscherichia coli [TaxID: 562]
Proteomesi
  • UP000009087 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

  • virion Source: UniProtKB-SubCell

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000791821 – 206Prohead core protein proteaseAdd BLAST206
PropeptideiPRO_0000224184207 – 2126

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei206 – 207Cleavage; by autolysisSequence analysis2

Keywords - PTMi

Autocatalytic cleavage

Structurei

Secondary structure

1212
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SMRiP06807
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase U9 family.Curated

Phylogenomic databases

OrthoDBiVOG090000OF

Family and domain databases

InterProiView protein in InterPro
IPR005082 Peptidase_U9_T4_prohead
PfamiView protein in Pfam
PF03420 Peptidase_S77, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD111331 Peptidase_U9_prohead_core, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06807-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNEPQLLIET WGQPGEIIDG VPMLESHDGK DLGLKPGLYI EGIFMQAEVV
60 70 80 90 100
NRNKRLYPKR ILEKAVKDYI NEQVLTKQAL GELNHPPRAN VDPMQAAIII
110 120 130 140 150
EDMWWKGNDV YGRARVIEGD HGPGDKLAAN IRAGWIPGVS SRGLGSLTDT
160 170 180 190 200
NEGYRIVNEG FKLTVGVDAV WGPSAPDAWV TPKEITESQT AEADTSADDA
210
YMALAEAMKK AL
Length:212
Mass (Da):23,251
Last modified:December 19, 2001 - v2
Checksum:i8CB2A799B10CF44F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13Q → K (PubMed:6512858).Curated1
Sequence conflicti152E → K in AAA32501 (PubMed:3552886).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15359 Genomic DNA Translation: AAA32501.1
AF158101 Genomic DNA Translation: AAD42426.1
J02512 Genomic DNA Translation: AAA32522.1
X01414 Genomic DNA Translation: CAA25657.1
PIRiJF0025 GPBPT4
RefSeqiNP_049785.1, NC_000866.4

Genome annotation databases

GeneIDi1258771
KEGGivg:1258771

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15359 Genomic DNA Translation: AAA32501.1
AF158101 Genomic DNA Translation: AAD42426.1
J02512 Genomic DNA Translation: AAA32522.1
X01414 Genomic DNA Translation: CAA25657.1
PIRiJF0025 GPBPT4
RefSeqiNP_049785.1, NC_000866.4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5JBLX-ray1.94A/B/C/D/E1-212[»]
SMRiP06807
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS77.001

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1258771
KEGGivg:1258771

Phylogenomic databases

OrthoDBiVOG090000OF

Family and domain databases

InterProiView protein in InterPro
IPR005082 Peptidase_U9_T4_prohead
PfamiView protein in Pfam
PF03420 Peptidase_S77, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD111331 Peptidase_U9_prohead_core, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPCPP_BPT4
AccessioniPrimary (citable) accession number: P06807
Secondary accession number(s): Q38427, Q9T0U1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: December 19, 2001
Last modified: November 22, 2017
This is version 83 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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