UniProtKB - P06804 (TNFA_MOUSE)
Protein
Tumor necrosis factor
Gene
Tnf
Organism
Mus musculus (Mouse)
Status
Functioni
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (PubMed:25586176). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity).By similarity1 Publication
The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.By similarity
GO - Molecular functioni
- cytokine activity Source: MGI
- identical protein binding Source: MGI
- protease binding Source: BHF-UCL
- transcription regulatory region sequence-specific DNA binding Source: MGI
- tumor necrosis factor receptor binding Source: MGI
GO - Biological processi
- activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
- activation of MAPK activity Source: MGI
- activation of MAPKKK activity Source: MGI
- animal organ morphogenesis Source: MGI
- apoptotic process Source: MGI
- apoptotic signaling pathway Source: MGI
- calcium-mediated signaling Source: MGI
- cell activation Source: MGI
- cellular extravasation Source: MGI
- cellular response to amino acid stimulus Source: MGI
- cellular response to lipopolysaccharide Source: MGI
- cellular response to nicotine Source: MGI
- cellular response to organic cyclic compound Source: MGI
- chronic inflammatory response to antigenic stimulus Source: MGI
- cortical actin cytoskeleton organization Source: MGI
- defense response Source: MGI
- defense response to bacterium Source: MGI
- defense response to Gram-positive bacterium Source: MGI
- detection of mechanical stimulus involved in sensory perception of pain Source: MGI
- embryonic digestive tract development Source: Ensembl
- endothelial cell apoptotic process Source: BHF-UCL
- epithelial cell proliferation involved in salivary gland morphogenesis Source: MGI
- extracellular matrix organization Source: MGI
- extrinsic apoptotic signaling pathway Source: MGI
- extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
- fractalkine production Source: MGI
- glucose metabolic process Source: MGI
- humoral immune response Source: MGI
- inflammatory response Source: MGI
- intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
- JNK cascade Source: MGI
- leukocyte migration Source: MGI
- leukocyte tethering or rolling Source: MGI
- lipopolysaccharide-mediated signaling pathway Source: MGI
- MAPK cascade Source: MGI
- microglial cell activation Source: ARUK-UCL
- multicellular organism development Source: MGI
- necroptotic signaling pathway Source: MGI
- negative regulation of alkaline phosphatase activity Source: BHF-UCL
- negative regulation of amyloid-beta clearance Source: ARUK-UCL
- negative regulation of apoptotic process Source: MGI
- negative regulation of apoptotic signaling pathway Source: MGI
- negative regulation of bicellular tight junction assembly Source: MGI
- negative regulation of bile acid secretion Source: MGI
- negative regulation of blood vessel endothelial cell migration Source: MGI
- negative regulation of branching involved in lung morphogenesis Source: MGI
- negative regulation of cell population proliferation Source: MGI
- negative regulation of cellular biosynthetic process Source: MGI
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
- negative regulation of cytokine production involved in immune response Source: MGI
- negative regulation of endothelial cell proliferation Source: BHF-UCL
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
- negative regulation of fat cell differentiation Source: MGI
- negative regulation of gene expression Source: MGI
- negative regulation of glucose import Source: MGI
- negative regulation of heart rate Source: MGI
- negative regulation of interleukin-6 production Source: MGI
- negative regulation of L-glutamate import across plasma membrane Source: MGI
- negative regulation of lipid catabolic process Source: MGI
- negative regulation of mitotic cell cycle Source: BHF-UCL
- negative regulation of myelination Source: MGI
- negative regulation of myoblast differentiation Source: MGI
- negative regulation of myosin-light-chain-phosphatase activity Source: MGI
- negative regulation of osteoblast differentiation Source: BHF-UCL
- negative regulation of oxidative phosphorylation Source: MGI
- negative regulation of production of miRNAs involved in gene silencing by miRNA Source: MGI
- negative regulation of protein-containing complex disassembly Source: UniProtKB
- negative regulation of signaling receptor activity Source: Ensembl
- negative regulation of systemic arterial blood pressure Source: MGI
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- negative regulation of vascular wound healing Source: MGI
- negative regulation of viral genome replication Source: MGI
- osteoclast differentiation Source: MGI
- positive regulation of action potential Source: MGI
- positive regulation of amyloid-beta formation Source: ARUK-UCL
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of blood microparticle formation Source: MGI
- positive regulation of calcidiol 1-monooxygenase activity Source: MGI
- positive regulation of calcineurin-NFAT signaling cascade Source: MGI
- positive regulation of cell adhesion Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of chemokine (C-X-C motif) ligand 2 production Source: MGI
- positive regulation of chemokine production Source: MGI
- positive regulation of chronic inflammatory response to antigenic stimulus Source: MGI
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
- positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis Source: MGI
- positive regulation of cytokine production Source: MGI
- positive regulation of cytokine production involved in inflammatory response Source: MGI
- positive regulation of DNA-binding transcription factor activity Source: MGI
- positive regulation of DNA biosynthetic process Source: MGI
- positive regulation of extrinsic apoptotic signaling pathway Source: GO_Central
- positive regulation of fever generation Source: BHF-UCL
- positive regulation of gene expression Source: ARUK-UCL
- positive regulation of glial cell proliferation Source: MGI
- positive regulation of hair follicle development Source: UniProtKB
- positive regulation of hepatocyte proliferation Source: MGI
- positive regulation of heterotypic cell-cell adhesion Source: BHF-UCL
- positive regulation of humoral immune response mediated by circulating immunoglobulin Source: MGI
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
- positive regulation of I-kappaB phosphorylation Source: MGI
- positive regulation of inflammatory response Source: MGI
- positive regulation of interferon-gamma production Source: MGI
- positive regulation of interleukin-18 production Source: MGI
- positive regulation of interleukin-1 beta production Source: MGI
- positive regulation of interleukin-33 production Source: MGI
- positive regulation of interleukin-6 production Source: MGI
- positive regulation of interleukin-8 production Source: MGI
- positive regulation of JNK cascade Source: MGI
- positive regulation of JUN kinase activity Source: UniProtKB
- positive regulation of leukocyte adhesion to arterial endothelial cell Source: MGI
- positive regulation of leukocyte adhesion to vascular endothelial cell Source: MGI
- positive regulation of MAP kinase activity Source: UniProtKB
- positive regulation of membrane protein ectodomain proteolysis Source: MGI
- positive regulation of mitotic nuclear division Source: MGI
- positive regulation of neuron apoptotic process Source: ARUK-UCL
- positive regulation of neutrophil activation Source: MGI
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of NIK/NF-kappaB signaling Source: BHF-UCL
- positive regulation of nitric oxide biosynthetic process Source: MGI
- positive regulation of nitric-oxide synthase activity Source: MGI
- positive regulation of nitrogen compound metabolic process Source: ARUK-UCL
- positive regulation of osteoclast differentiation Source: MGI
- positive regulation of oxidative stress-induced neuron death Source: MGI
- positive regulation of peptidyl-serine phosphorylation Source: MGI
- positive regulation of phagocytosis Source: MGI
- positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
- positive regulation of podosome assembly Source: MGI
- positive regulation of pri-miRNA transcription by RNA polymerase II Source: MGI
- positive regulation of programmed cell death Source: MGI
- positive regulation of protein catabolic process Source: MGI
- positive regulation of protein-containing complex assembly Source: MGI
- positive regulation of protein-containing complex disassembly Source: UniProtKB
- positive regulation of protein kinase activity Source: MGI
- positive regulation of protein kinase B signaling Source: MGI
- positive regulation of protein localization to cell surface Source: MGI
- positive regulation of protein localization to plasma membrane Source: ARUK-UCL
- positive regulation of protein phosphorylation Source: UniProtKB
- positive regulation of protein transport Source: MGI
- positive regulation of receptor signaling pathway via JAK-STAT Source: MGI
- positive regulation of smooth muscle cell proliferation Source: MGI
- positive regulation of superoxide dismutase activity Source: MGI
- positive regulation of synaptic transmission Source: ARUK-UCL
- positive regulation of synoviocyte proliferation Source: MGI
- positive regulation of transcription, DNA-templated Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of translational initiation by iron Source: MGI
- positive regulation of tyrosine phosphorylation of STAT protein Source: MGI
- positive regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCL
- positive regulation of vitamin D biosynthetic process Source: MGI
- protein kinase B signaling Source: MGI
- protein localization to plasma membrane Source: MGI
- regulation of branching involved in salivary gland morphogenesis Source: MGI
- regulation of cell population proliferation Source: MGI
- regulation of endothelial cell apoptotic process Source: MGI
- regulation of establishment of endothelial barrier Source: MGI
- regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
- regulation of immunoglobulin secretion Source: MGI
- regulation of inflammatory response Source: MGI
- regulation of insulin secretion Source: MGI
- regulation of osteoclast differentiation Source: MGI
- regulation of protein phosphorylation Source: MGI
- regulation of protein secretion Source: MGI
- regulation of reactive oxygen species metabolic process Source: MGI
- regulation of synapse organization Source: ARUK-UCL
- regulation of transcription by RNA polymerase II Source: MGI
- response to glucocorticoid Source: MGI
- response to lipopolysaccharide Source: MGI
- response to organic substance Source: MGI
- response to virus Source: MGI
- sequestering of triglyceride Source: MGI
- signal transduction Source: MGI
- toll-like receptor 3 signaling pathway Source: MGI
- tumor necrosis factor-mediated signaling pathway Source: MGI
- vascular endothelial growth factor production Source: UniProtKB
- vasodilation Source: MGI
Keywordsi
Molecular function | Cytokine |
Enzyme and pathway databases
Reactomei | R-MMU-5357786, TNFR1-induced proapoptotic signaling R-MMU-5357905, Regulation of TNFR1 signaling R-MMU-5357956, TNFR1-induced NFkappaB signaling pathway R-MMU-5626978, TNFR1-mediated ceramide production R-MMU-5668541, TNFR2 non-canonical NF-kB pathway R-MMU-75893, TNF signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Tumor necrosis factorAlternative name(s): Cachectin TNF-alpha Tumor necrosis factor ligand superfamily member 2 Short name: TNF-a Cleaved into the following 6 chains: Alternative name(s): N-terminal fragment Short name: NTF |
Gene namesi | Name:Tnf Synonyms:Tnfa, Tnfsf2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:104798, Tnf |
Subcellular locationi
Plasma membrane
Other locations
- Membrane By similarity; Single-pass type II membrane protein By similarity
Extracellular region or secreted
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- Secreted By similarity
Endosome
- recycling endosome Source: BHF-UCL
Extracellular region or secreted
- extracellular space Source: MGI
Plasma Membrane
- external side of plasma membrane Source: BHF-UCL
- integral component of plasma membrane Source: MGI
- phagocytic cup Source: BHF-UCL
- plasma membrane Source: MGI
Other locations
- cell surface Source: MGI
- cytoplasm Source: MGI
- membrane raft Source: BHF-UCL
- neuronal cell body Source: MGI
- secretory granule Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 35 | CytoplasmicSequence analysisAdd BLAST | 35 | |
Transmembranei | 36 – 56 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 57 – 235 | ExtracellularSequence analysisAdd BLAST | 179 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000034435 | 1 – 235 | Tumor necrosis factor, membrane formAdd BLAST | 235 | |
ChainiPRO_0000417255 | 1 – 39 | Intracellular domain 1By similarityAdd BLAST | 39 | |
ChainiPRO_0000417256 | 1 – 35 | Intracellular domain 2By similarityAdd BLAST | 35 | |
ChainiPRO_0000417257 | 50 – ? | C-domain 1By similarity | ||
ChainiPRO_0000417258 | 52 – ? | C-domain 2By similarity | ||
ChainiPRO_0000034436 | 80 – 235 | Tumor necrosis factor, soluble formAdd BLAST | 156 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | Phosphoserine; by CK1By similarity | 1 | |
Lipidationi | 20 | N6-myristoyl lysineBy similarity | 1 | |
Glycosylationi | 83 | O-linked (GalNAc...) serine; in soluble formBy similarity | 1 | |
Glycosylationi | 86 | N-linked (GlcNAc...) asparagine | 1 | |
Disulfide bondi | 148 ↔ 179 |
Post-translational modificationi
The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space (By similarity). The soluble form derives from the membrane form by proteolytic processing.By similarity
The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity).By similarity
O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 34 – 35 | Cleavage; by SPPL2A or SPPL2BBy similarity | 2 | |
Sitei | 39 – 40 | Cleavage; by SPPL2A or SPPL2BBy similarity | 2 | |
Sitei | 49 – 50 | Cleavage; by SPPL2A or SPPL2BBy similarity | 2 | |
Sitei | 51 – 52 | Cleavage; by SPPL2A or SPPL2BBy similarity | 2 | |
Sitei | 79 – 80 | Cleavage; by ADAM17By similarity | 2 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Myristate, PhosphoproteinProteomic databases
EPDi | P06804 |
PaxDbi | P06804 |
PRIDEi | P06804 |
PTM databases
GlyGeni | P06804, 2 sites |
iPTMneti | P06804 |
PhosphoSitePlusi | P06804 |
SwissPalmi | P06804 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000024401, Expressed in granulocyte and 96 other tissues |
ExpressionAtlasi | P06804, baseline and differential |
Genevisiblei | P06804, MM |
Interactioni
Subunit structurei
Interacts with SPPL2B (By similarity). Homotrimer.
By similarityGO - Molecular functioni
- cytokine activity Source: MGI
- identical protein binding Source: MGI
- protease binding Source: BHF-UCL
- tumor necrosis factor receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204240, 20 interactors |
DIPi | DIP-40029N |
IntActi | P06804, 2 interactors |
STRINGi | 10090.ENSMUSP00000025263 |
Chemistry databases
BindingDBi | P06804 |
Miscellaneous databases
RNActi | P06804, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P06804 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P06804 |
Family & Domainsi
Sequence similaritiesi
Belongs to the tumor necrosis factor family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S4K8, Eukaryota |
GeneTreei | ENSGT01010000222306 |
HOGENOMi | CLU_070352_3_1_1 |
InParanoidi | P06804 |
OMAi | GATMLFC |
OrthoDBi | 1124938at2759 |
PhylomeDBi | P06804 |
TreeFami | TF332169 |
Family and domain databases
CDDi | cd00184, TNF, 1 hit |
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR006053, TNF IPR002959, TNF_alpha IPR021184, TNF_CS IPR006052, TNF_dom IPR008983, Tumour_necrosis_fac-like_dom |
PANTHERi | PTHR11471:SF23, PTHR11471:SF23, 1 hit |
Pfami | View protein in Pfam PF00229, TNF, 1 hit |
PRINTSi | PR01234, TNECROSISFCT PR01235, TNFALPHA |
SMARTi | View protein in SMART SM00207, TNF, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS00251, TNF_1, 1 hit PS50049, TNF_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P06804-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTESMIRDV ELAEEALPQK MGGFQNSRRC LCLSLFSFLL VAGATTLFCL
60 70 80 90 100
LNFGVIGPQR DEKFPNGLPL ISSMAQTLTL RSSSQNSSDK PVAHVVANHQ
110 120 130 140 150
VEEQLEWLSQ RANALLANGM DLKDNQLVVP ADGLYLVYSQ VLFKGQGCPD
160 170 180 190 200
YVLLTHTVSR FAISYQEKVN LLSAVKSPCP KDTPEGAELK PWYEPIYLGG
210 220 230
VFQLEKGDQL SAEVNLPKYL DFAESGQVYF GVIAL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4J210 | A0A0R4J210_MOUSE | C-domain 1 | Tnf | 219 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 79 – 81 | Missing in AAB65593 (PubMed:9089109).Curated | 3 | |
Sequence conflicti | 231 | G → R (PubMed:2419912).Curated | 1 | |
Sequence conflicti | 231 | G → R (PubMed:2989794).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 7 | I → T in strain: BALB/c and C57BL/6. 1 Publication | 1 | |
Natural varianti | 77 | T → A in strain: BALB/c and C57BL/6. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M20155 Genomic DNA Translation: AAA40462.1 Sequence problems. M11731 mRNA Translation: AAA40458.1 M13049 mRNA Translation: AAA40457.1 X02611 mRNA Translation: CAA26457.1 M38296 Genomic DNA Translation: AAA40459.1 Y00467 Genomic DNA Translation: CAA68530.1 U06950 Unassigned DNA Translation: AAA18594.1 D84196 Genomic DNA Translation: BAA19512.1 D84199 Genomic DNA Translation: BAA19513.1 U68414 Genomic DNA Translation: AAB65593.1 AF109719 Genomic DNA Translation: AAC82484.1 AB039224 Genomic DNA Translation: BAB68748.1 Sequence problems. AB039225 Genomic DNA Translation: BAB68749.1 Sequence problems. AB039226 Genomic DNA Translation: BAB68750.1 Sequence problems. AB039227 Genomic DNA Translation: BAB68751.1 Sequence problems. AB039228 Genomic DNA Translation: BAB68752.1 Sequence problems. AB039229 Genomic DNA Translation: BAB68753.1 Sequence problems. AB039230 Genomic DNA Translation: BAB68754.1 Sequence problems. AB039231 Genomic DNA Translation: BAB68755.1 Sequence problems. AB039232 Genomic DNA Translation: BAB68756.1 Sequence problems. |
CCDSi | CCDS28691.1 |
PIRi | A22908, QWMSN |
RefSeqi | NP_001265530.1, NM_001278601.1 NP_038721.1, NM_013693.3 |
Genome annotation databases
Ensembli | ENSMUST00000025263; ENSMUSP00000025263; ENSMUSG00000024401 |
GeneIDi | 21926 |
KEGGi | mmu:21926 |
UCSCi | uc008cgr.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M20155 Genomic DNA Translation: AAA40462.1 Sequence problems. M11731 mRNA Translation: AAA40458.1 M13049 mRNA Translation: AAA40457.1 X02611 mRNA Translation: CAA26457.1 M38296 Genomic DNA Translation: AAA40459.1 Y00467 Genomic DNA Translation: CAA68530.1 U06950 Unassigned DNA Translation: AAA18594.1 D84196 Genomic DNA Translation: BAA19512.1 D84199 Genomic DNA Translation: BAA19513.1 U68414 Genomic DNA Translation: AAB65593.1 AF109719 Genomic DNA Translation: AAC82484.1 AB039224 Genomic DNA Translation: BAB68748.1 Sequence problems. AB039225 Genomic DNA Translation: BAB68749.1 Sequence problems. AB039226 Genomic DNA Translation: BAB68750.1 Sequence problems. AB039227 Genomic DNA Translation: BAB68751.1 Sequence problems. AB039228 Genomic DNA Translation: BAB68752.1 Sequence problems. AB039229 Genomic DNA Translation: BAB68753.1 Sequence problems. AB039230 Genomic DNA Translation: BAB68754.1 Sequence problems. AB039231 Genomic DNA Translation: BAB68755.1 Sequence problems. AB039232 Genomic DNA Translation: BAB68756.1 Sequence problems. |
CCDSi | CCDS28691.1 |
PIRi | A22908, QWMSN |
RefSeqi | NP_001265530.1, NM_001278601.1 NP_038721.1, NM_013693.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2TNF | X-ray | 1.40 | A/B/C | 80-234 | [»] | |
SMRi | P06804 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 204240, 20 interactors |
DIPi | DIP-40029N |
IntActi | P06804, 2 interactors |
STRINGi | 10090.ENSMUSP00000025263 |
Chemistry databases
BindingDBi | P06804 |
ChEMBLi | CHEMBL4984 |
PTM databases
GlyGeni | P06804, 2 sites |
iPTMneti | P06804 |
PhosphoSitePlusi | P06804 |
SwissPalmi | P06804 |
Proteomic databases
EPDi | P06804 |
PaxDbi | P06804 |
PRIDEi | P06804 |
Protocols and materials databases
Antibodypediai | 27196, 4789 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000025263; ENSMUSP00000025263; ENSMUSG00000024401 |
GeneIDi | 21926 |
KEGGi | mmu:21926 |
UCSCi | uc008cgr.2, mouse |
Organism-specific databases
CTDi | 7124 |
MGIi | MGI:104798, Tnf |
Phylogenomic databases
eggNOGi | ENOG502S4K8, Eukaryota |
GeneTreei | ENSGT01010000222306 |
HOGENOMi | CLU_070352_3_1_1 |
InParanoidi | P06804 |
OMAi | GATMLFC |
OrthoDBi | 1124938at2759 |
PhylomeDBi | P06804 |
TreeFami | TF332169 |
Enzyme and pathway databases
Reactomei | R-MMU-5357786, TNFR1-induced proapoptotic signaling R-MMU-5357905, Regulation of TNFR1 signaling R-MMU-5357956, TNFR1-induced NFkappaB signaling pathway R-MMU-5626978, TNFR1-mediated ceramide production R-MMU-5668541, TNFR2 non-canonical NF-kB pathway R-MMU-75893, TNF signaling |
Miscellaneous databases
BioGRID-ORCSi | 21926, 0 hits in 17 CRISPR screens |
ChiTaRSi | Tnf, mouse |
EvolutionaryTracei | P06804 |
PROi | PR:P06804 |
RNActi | P06804, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024401, Expressed in granulocyte and 96 other tissues |
ExpressionAtlasi | P06804, baseline and differential |
Genevisiblei | P06804, MM |
Family and domain databases
CDDi | cd00184, TNF, 1 hit |
Gene3Di | 2.60.120.40, 1 hit |
InterProi | View protein in InterPro IPR006053, TNF IPR002959, TNF_alpha IPR021184, TNF_CS IPR006052, TNF_dom IPR008983, Tumour_necrosis_fac-like_dom |
PANTHERi | PTHR11471:SF23, PTHR11471:SF23, 1 hit |
Pfami | View protein in Pfam PF00229, TNF, 1 hit |
PRINTSi | PR01234, TNECROSISFCT PR01235, TNFALPHA |
SMARTi | View protein in SMART SM00207, TNF, 1 hit |
SUPFAMi | SSF49842, SSF49842, 1 hit |
PROSITEi | View protein in PROSITE PS00251, TNF_1, 1 hit PS50049, TNF_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TNFA_MOUSE | |
Accessioni | P06804Primary (citable) accession number: P06804 Secondary accession number(s): O35853, Q62326, Q91VF3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | July 1, 1989 | |
Last modified: | February 10, 2021 | |
This is version 216 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families