UniProtKB - P06800 (PTPRC_MOUSE)
Receptor-type tyrosine-protein phosphatase C
Ptprc
Functioni
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity).
Dephosphorylates LYN, and thereby modulates LYN activity.
By similarity1 PublicationCaution
Catalytic activityi
- EC:3.1.3.48PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 810 | SubstrateBy similarity | 1 | |
Active sitei | 842 | Phosphocysteine intermediateBy similarity | 1 | |
Binding sitei | 886 | SubstrateBy similarity | 1 | |
Active sitei | 1157 | Phosphocysteine intermediateBy similarity | 1 |
GO - Molecular functioni
- ankyrin binding Source: MGI
- heparan sulfate proteoglycan binding Source: MGI
- heparin binding Source: MGI
- protein kinase binding Source: UniProtKB
- protein tyrosine phosphatase activity Source: MGI
- signaling receptor binding Source: ARUK-UCL
- spectrin binding Source: MGI
GO - Biological processi
- B cell differentiation Source: ARUK-UCL
- B cell proliferation Source: UniProtKB
- B cell receptor signaling pathway Source: UniProtKB
- bone marrow development Source: MGI
- calcium-mediated signaling using intracellular calcium source Source: ARUK-UCL
- cell cycle phase transition Source: MGI
- cellular response to extracellular stimulus Source: ARUK-UCL
- defense response to virus Source: MGI
- dephosphorylation Source: UniProtKB
- hematopoietic progenitor cell differentiation Source: MGI
- heterotypic cell-cell adhesion Source: MGI
- leukocyte cell-cell adhesion Source: MGI
- natural killer cell differentiation Source: ARUK-UCL
- negative regulation of cell adhesion involved in substrate-bound cell migration Source: MGI
- negative regulation of cytokine-mediated signaling pathway Source: UniProtKB
- negative regulation of ERK1 and ERK2 cascade Source: ARUK-UCL
- negative regulation of interleukin-2 production Source: ARUK-UCL
- negative regulation of peptidyl-tyrosine phosphorylation Source: MGI
- negative regulation of protein autophosphorylation Source: MGI
- negative regulation of protein kinase activity Source: UniProtKB
- negative regulation of protein tyrosine kinase activity Source: ARUK-UCL
- negative regulation of T cell mediated cytotoxicity Source: UniProtKB
- negative thymic T cell selection Source: MGI
- plasma membrane raft distribution Source: ARUK-UCL
- positive regulation of alpha-beta T cell proliferation Source: MGI
- positive regulation of antigen receptor-mediated signaling pathway Source: UniProtKB
- positive regulation of B cell proliferation Source: MGI
- positive regulation of ERK1 and ERK2 cascade Source: ARUK-UCL
- positive regulation of extrinsic apoptotic signaling pathway Source: MGI
- positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Source: ARUK-UCL
- positive regulation of gamma-delta T cell differentiation Source: MGI
- positive regulation of hematopoietic stem cell migration Source: MGI
- positive regulation of humoral immune response mediated by circulating immunoglobulin Source: MGI
- positive regulation of immunoglobulin production Source: MGI
- positive regulation of interleukin-2 production Source: ARUK-UCL
- positive regulation of isotype switching to IgG isotypes Source: MGI
- positive regulation of MAPK cascade Source: MGI
- positive regulation of MAP kinase activity Source: MGI
- positive regulation of peptidyl-tyrosine phosphorylation Source: ARUK-UCL
- positive regulation of protein tyrosine phosphatase activity Source: ARUK-UCL
- positive regulation of stem cell proliferation Source: MGI
- positive regulation of T cell differentiation Source: MGI
- positive regulation of T cell mediated cytotoxicity Source: MGI
- positive regulation of T cell mediated immunity Source: MGI
- positive regulation of T cell proliferation Source: UniProtKB
- positive regulation of tumor necrosis factor production Source: ARUK-UCL
- positive thymic T cell selection Source: MGI
- protein dephosphorylation Source: UniProtKB
- regulation of cell cycle Source: UniProtKB
- regulation of extrinsic apoptotic signaling pathway Source: MGI
- regulation of gene expression Source: ARUK-UCL
- regulation of humoral immune response mediated by circulating immunoglobulin Source: MGI
- regulation of interleukin-8 production Source: MGI
- regulation of phagocytosis Source: MGI
- regulation of protein tyrosine kinase activity Source: MGI
- regulation of receptor signaling pathway via JAK-STAT Source: MGI
- release of sequestered calcium ion into cytosol Source: UniProtKB
- response to gamma radiation Source: MGI
- stem cell development Source: MGI
- T cell differentiation Source: UniProtKB
- T cell proliferation Source: MGI
- T cell receptor signaling pathway Source: ARUK-UCL
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Enzyme and pathway databases
Reactomei | R-MMU-202427, Phosphorylation of CD3 and TCR zeta chains R-MMU-416700, Other semaphorin interactions R-MMU-6798695, Neutrophil degranulation |
Names & Taxonomyi
Protein namesi | Recommended name: Receptor-type tyrosine-protein phosphatase CCurated (EC:3.1.3.48)Alternative name(s): Leukocyte common antigen Short name: L-CA Lymphocyte antigen 5 Short name: Ly-5 T200 CD_antigen: CD45 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:97810, Ptprc |
VEuPathDBi | HostDB:ENSMUSG00000026395 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Single-pass type I membrane protein Sequence analysis
Other locations
- Membrane raft By similarity
Note: Colocalized with DPP4 in membrane rafts.By similarity
Plasma Membrane
- cytoplasmic side of plasma membrane Source: ARUK-UCL
- external side of plasma membrane Source: MGI
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: MGI
Other locations
- bleb Source: MGI
- cell periphery Source: MGI
- cell surface Source: MGI
- focal adhesion Source: UniProtKB
- integral component of membrane Source: MGI
- membrane microdomain Source: ARUK-UCL
- membrane raft Source: ARUK-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 26 – 566 | ExtracellularSequence analysisAdd BLAST | 541 | |
Transmembranei | 567 – 588 | HelicalSequence analysisAdd BLAST | 22 | |
Topological domaini | 589 – 1293 | CytoplasmicSequence analysisAdd BLAST | 705 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Add BLAST | 25 | |
ChainiPRO_0000025471 | 26 – 1293 | Receptor-type tyrosine-protein phosphatase CAdd BLAST | 1268 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 66 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 152 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 163 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 209 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 213 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 220 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 255 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 260 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 292 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 313 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 324 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 349 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 418 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 429 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 459 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 491 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 672 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 964 | PhosphoserineCombined sources | 1 | |
Modified residuei | 983 | PhosphoserineBy similarity | 1 | |
Modified residuei | 986 | PhosphoserineBy similarity | 1 | |
Modified residuei | 990 | PhosphoserineBy similarity | 1 | |
Modified residuei | 993 | PhosphoserineBy similarity | 1 | |
Modified residuei | 994 | PhosphoserineCombined sources | 1 | |
Modified residuei | 998 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1229 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1267 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1286 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | P06800 |
MaxQBi | P06800 |
PaxDbi | P06800 |
PeptideAtlasi | P06800 |
PRIDEi | P06800 |
ProteomicsDBi | 301943 [P06800-4] 314731 337221 |
PTM databases
GlyConnecti | 2666, 1 N-Linked glycan (1 site) |
GlyGeni | P06800, 16 sites |
iPTMneti | P06800 |
PhosphoSitePlusi | P06800 |
SwissPalmi | P06800 |
Expressioni
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000026395, Expressed in spleen and 225 other tissues |
Interactioni
Subunit structurei
Interacts with SKAP1.
Interacts with DPP4; the interaction is enhanced in an interleukin-12-dependent manner in activated lymphocytes (By similarity). Binds GANAB and PRKCSH.
By similarity1 PublicationBinary interactionsi
P06800
With | #Exp. | IntAct |
---|---|---|
Lck [P06240] | 2 | EBI-1672,EBI-1401 |
GO - Molecular functioni
- ankyrin binding Source: MGI
- heparan sulfate proteoglycan binding Source: MGI
- protein kinase binding Source: UniProtKB
- signaling receptor binding Source: ARUK-UCL
- spectrin binding Source: MGI
Protein-protein interaction databases
IntActi | P06800, 10 interactors |
MINTi | P06800 |
STRINGi | 10090.ENSMUSP00000138350 |
Miscellaneous databases
RNActi | P06800, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 376 – 472 | Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST | 97 | |
Domaini | 473 – 568 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 642 – 901 | Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST | 260 | |
Domaini | 933 – 1216 | Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST | 284 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 43 – 174 | DisorderedSequence analysisAdd BLAST | 132 | |
Regioni | 842 – 848 | Substrate bindingBy similarity | 7 | |
Regioni | 980 – 1003 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 1240 – 1293 | DisorderedSequence analysisAdd BLAST | 54 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 43 – 76 | Polar residuesSequence analysisAdd BLAST | 34 | |
Compositional biasi | 84 – 114 | Polar residuesSequence analysisAdd BLAST | 31 | |
Compositional biasi | 146 – 174 | Polar residuesSequence analysisAdd BLAST | 29 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4228, Eukaryota |
GeneTreei | ENSGT00940000159457 |
InParanoidi | P06800 |
OMAi | KHHKNAP |
TreeFami | TF351829 |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 2.60.40.10, 2 hits 3.90.190.10, 2 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTP_cat IPR024739, PTP_recept_N IPR016335, Ptprc IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, Tyr_Pase_dom |
Pfami | View protein in Pfam PF12567, CD45, 1 hit PF12453, PTP_N, 1 hit PF00102, Y_phosphatase, 2 hits |
PIRSFi | PIRSF002004, Leukocyte_common_antigen, 1 hit |
PRINTSi | PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00060, FN3, 2 hits SM00194, PTPc, 2 hits SM00404, PTPc_motif, 2 hits |
SUPFAMi | SSF49265, SSF49265, 2 hits SSF52799, SSF52799, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS00383, TYR_PHOSPHATASE_1, 1 hit PS50056, TYR_PHOSPHATASE_2, 2 hits PS50055, TYR_PHOSPHATASE_PTP, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTMGLWLKLL AFGFALLDTE VFVTGQTPTP SDELSTTENA LLLPQSDPLP
60 70 80 90 100
ARTTESTPPS ISERGNGSSE TTYHPGVLST LLPHLSPQPD SQTPSAGGAD
110 120 130 140 150
TQTFSSQADN PTLTPAPGGG TDPPGVPGER TVPGTIPADT AFPVDTPSLA
160 170 180 190 200
RNSSAASPTH TSNVSTTDIS SGASLTTLTP STLGLASTDP PSTTIATTTK
210 220 230 240 250
QTCAAMFGNI TVNYTYESSN QTFKADLKDV QNAKCGNEDC ENVLNNLEEC
260 270 280 290 300
SQIKNISVSN DSCAPATTID LYVPPGTDKF SLHDCTPKEK ANTSICLEWK
310 320 330 340 350
TKNLDFRKCN SDNISYVLHC EPENNTKCIR RNTFIPERCQ LDNLRAQTNY
360 370 380 390 400
TCVAEILYRG VKLVKNVINV QTDLGIPETP KPSCGDPAAR KTLVSWPEPV
410 420 430 440 450
SKPESASKPH GYVLCYKNNS EKCKSLPNNV TSFEVESLKP YKYYEVSLLA
460 470 480 490 500
YVNGKIQRNG TAEKCNFHTK ADRPDKVNGM KTSRPTDNSI NVTCGPPYET
510 520 530 540 550
NGPKTFYILV VRSGGSFVTK YNKTNCQFYV DNLYYSTDYE FLVSFHNGVY
560 570 580 590 600
EGDSVIRNES TNFNAKALII FLVFLIIVTS IALLVVLYKI YDLRKKRSSN
610 620 630 640 650
LDEQQELVER DDEKQLMDVE PIHSDILLET YKRKIADEGR LFLAEFQSIP
660 670 680 690 700
RVFSKFPIKD ARKPHNQNKN RYVDILPYDY NRVELSEING DAGSTYINAS
710 720 730 740 750
YIDGFKEPRK YIAAQGPRDE TVDDFWRMIW EQKATVIVMV TRCEEGNRNK
760 770 780 790 800
CAEYWPSMEE GTRAFKDIVV TINDHKRCPD YIIQKLNVAH KKEKATGREV
810 820 830 840 850
THIQFTSWPD HGVPEDPHLL LKLRRRVNAF SNFFSGPIVV HCSAGVGRTG
860 870 880 890 900
TYIGIDAMLE GLEAEGKVDV YGYVVKLRRQ RCLMVQVEAQ YILIHQALVE
910 920 930 940 950
YNQFGETEVN LSELHSCLHN MKKRDPPSDP SPLEAEYQRL PSYRSWRTQH
960 970 980 990 1000
IGNQEENKKK NRNSNVVPYD FNRVPLKHEL EMSKESEPES DESSDDDSDS
1010 1020 1030 1040 1050
EETSKYINAS FVMSYWKPEM MIAAQGPLKE TIGDFWQMIF QRKVKVIVML
1060 1070 1080 1090 1100
TELVNGDQEV CAQYWGEGKQ TYGDMEVEMK DTNRASAYTL RTFELRHSKR
1110 1120 1130 1140 1150
KEPRTVYQYQ CTTWKGEELP AEPKDLVSMI QDLKQKLPKA SPEGMKYHKH
1160 1170 1180 1190 1200
ASILVHCRDG SQQTGLFCAL FNLLESAETE DVVDVFQVVK SLRKARPGVV
1210 1220 1230 1240 1250
CSYEQYQFLY DIIASIYPAQ NGQVKKTNSQ DKIEFHNEVD GGKQDANCVR
1260 1270 1280 1290
PDGPLNKAQE DSRGVGTPEP TNSAEEPEHA ANGSASPAPT QSS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketS4R1M0 | S4R1M0_MOUSE | Protein-tyrosine-phosphatase | Ptprc | 1,130 | Annotation score: | ||
A0A0A6YXM4 | A0A0A6YXM4_MOUSE | Receptor-type tyrosine-protein phos... | Ptprc | 212 | Annotation score: | ||
A0A0A6YWF2 | A0A0A6YWF2_MOUSE | Receptor-type tyrosine-protein phos... | Ptprc | 94 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 302 | K → E in AAA39459 (PubMed:1822988).Curated | 1 | |
Sequence conflicti | 400 – 405 | VSKPES → ASKPDP in AAA39459 (PubMed:1822988).Curated | 6 | |
Sequence conflicti | 478 | N → T in AAA39459 (PubMed:1822988).Curated | 1 | |
Sequence conflicti | 530 | V → G in AAA39458 (PubMed:2944116).Curated | 1 | |
Sequence conflicti | 558 | N → S in AAA39458 (PubMed:2944116).Curated | 1 | |
Sequence conflicti | 590 | I → S in AAA39458 (PubMed:2944116).Curated | 1 | |
Sequence conflicti | 908 | E → Q in AAA39458 (PubMed:2944116).Curated | 1 | |
Sequence conflicti | 933 | L → R in AAA39458 (PubMed:2944116).Curated | 1 | |
Sequence conflicti | 955 | E → G in AAA39458 (PubMed:2944116).Curated | 1 | |
Sequence conflicti | 961 | N → K in AAA39458 (PubMed:2944116).Curated | 1 | |
Sequence conflicti | 966 – 969 | VVPY → CSID in AAA40161 (PubMed:2948186).Curated | 4 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_059410 | 33 – 171 | Missing in isoform 3. Add BLAST | 139 | |
Alternative sequenceiVSP_059411 | 33 – 75 | Missing in isoform 2. Add BLAST | 43 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14342 mRNA Translation: AAA39458.1 Different initiation. M92933 mRNA Translation: AAA39459.1 Different initiation. AC122903 Genomic DNA No translation available. AC159278 Genomic DNA No translation available. CH466520 Genomic DNA Translation: EDL39542.1 M17320 mRNA Translation: AAA60449.1 Different initiation. M23354 Genomic DNA Translation: AAA39462.1 M22456 Genomic DNA Translation: AAB46374.1 Different initiation. M11934 mRNA Translation: AAA39461.1 M23241 Genomic DNA Translation: AAA39460.1 M15174 mRNA Translation: AAA40161.1 Sequence problems. |
CCDSi | CCDS15330.2 [P06800-6] CCDS48383.2 [P06800-4] |
PIRi | A23329 A28334 A28335 I57644 |
RefSeqi | NP_001104786.2, NM_001111316.2 [P06800-4] NP_035340.3, NM_011210.4 [P06800-6] XP_006529320.1, XM_006529257.1 [P06800-4] XP_006529321.1, XM_006529258.3 [P06800-4] XP_006529322.1, XM_006529259.3 [P06800-4] XP_006529323.1, XM_006529260.1 [P06800-5] |
Genome annotation databases
Ensembli | ENSMUST00000182283; ENSMUSP00000138800; ENSMUSG00000026395 [P06800-6] ENSMUST00000183301; ENSMUSP00000138350; ENSMUSG00000026395 [P06800-4] |
GeneIDi | 19264 |
KEGGi | mmu:19264 |
UCSCi | uc007cvf.3, mouse [P06800-4] uc007cvh.3, mouse |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14342 mRNA Translation: AAA39458.1 Different initiation. M92933 mRNA Translation: AAA39459.1 Different initiation. AC122903 Genomic DNA No translation available. AC159278 Genomic DNA No translation available. CH466520 Genomic DNA Translation: EDL39542.1 M17320 mRNA Translation: AAA60449.1 Different initiation. M23354 Genomic DNA Translation: AAA39462.1 M22456 Genomic DNA Translation: AAB46374.1 Different initiation. M11934 mRNA Translation: AAA39461.1 M23241 Genomic DNA Translation: AAA39460.1 M15174 mRNA Translation: AAA40161.1 Sequence problems. |
CCDSi | CCDS15330.2 [P06800-6] CCDS48383.2 [P06800-4] |
PIRi | A23329 A28334 A28335 I57644 |
RefSeqi | NP_001104786.2, NM_001111316.2 [P06800-4] NP_035340.3, NM_011210.4 [P06800-6] XP_006529320.1, XM_006529257.1 [P06800-4] XP_006529321.1, XM_006529258.3 [P06800-4] XP_006529322.1, XM_006529259.3 [P06800-4] XP_006529323.1, XM_006529260.1 [P06800-5] |
3D structure databases
SMRi | P06800 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P06800, 10 interactors |
MINTi | P06800 |
STRINGi | 10090.ENSMUSP00000138350 |
PTM databases
GlyConnecti | 2666, 1 N-Linked glycan (1 site) |
GlyGeni | P06800, 16 sites |
iPTMneti | P06800 |
PhosphoSitePlusi | P06800 |
SwissPalmi | P06800 |
Proteomic databases
jPOSTi | P06800 |
MaxQBi | P06800 |
PaxDbi | P06800 |
PeptideAtlasi | P06800 |
PRIDEi | P06800 |
ProteomicsDBi | 301943 [P06800-4] 314731 337221 |
Protocols and materials databases
Antibodypediai | 737, 9420 antibodies from 53 providers |
DNASUi | 19264 |
Genome annotation databases
Ensembli | ENSMUST00000182283; ENSMUSP00000138800; ENSMUSG00000026395 [P06800-6] ENSMUST00000183301; ENSMUSP00000138350; ENSMUSG00000026395 [P06800-4] |
GeneIDi | 19264 |
KEGGi | mmu:19264 |
UCSCi | uc007cvf.3, mouse [P06800-4] uc007cvh.3, mouse |
Organism-specific databases
CTDi | 5788 |
MGIi | MGI:97810, Ptprc |
VEuPathDBi | HostDB:ENSMUSG00000026395 |
Phylogenomic databases
eggNOGi | KOG4228, Eukaryota |
GeneTreei | ENSGT00940000159457 |
InParanoidi | P06800 |
OMAi | KHHKNAP |
TreeFami | TF351829 |
Enzyme and pathway databases
Reactomei | R-MMU-202427, Phosphorylation of CD3 and TCR zeta chains R-MMU-416700, Other semaphorin interactions R-MMU-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 19264, 2 hits in 101 CRISPR screens |
ChiTaRSi | Ptprc, mouse |
PROi | PR:P06800 |
RNActi | P06800, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026395, Expressed in spleen and 225 other tissues |
Family and domain databases
CDDi | cd00063, FN3, 2 hits |
Gene3Di | 2.60.40.10, 2 hits 3.90.190.10, 2 hits |
InterProi | View protein in InterPro IPR003961, FN3_dom IPR036116, FN3_sf IPR013783, Ig-like_fold IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTP_cat IPR024739, PTP_recept_N IPR016335, Ptprc IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, Tyr_Pase_dom |
Pfami | View protein in Pfam PF12567, CD45, 1 hit PF12453, PTP_N, 1 hit PF00102, Y_phosphatase, 2 hits |
PIRSFi | PIRSF002004, Leukocyte_common_antigen, 1 hit |
PRINTSi | PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00060, FN3, 2 hits SM00194, PTPc, 2 hits SM00404, PTPc_motif, 2 hits |
SUPFAMi | SSF49265, SSF49265, 2 hits SSF52799, SSF52799, 2 hits |
PROSITEi | View protein in PROSITE PS50853, FN3, 2 hits PS00383, TYR_PHOSPHATASE_1, 1 hit PS50056, TYR_PHOSPHATASE_2, 2 hits PS50055, TYR_PHOSPHATASE_PTP, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | PTPRC_MOUSE | |
Accessioni | P06800Primary (citable) accession number: P06800 Secondary accession number(s): E9QLT5 S4R2V1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | March 28, 2018 | |
Last modified: | February 23, 2022 | |
This is version 218 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families