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Protein

Receptor-type tyrosine-protein phosphatase C

Gene

Ptprc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity.By similarity1 Publication

Caution

It is uncertain whether Met-1 or Met-3 is the initiator.Curated

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei810SubstrateBy similarity1
Active sitei842Phosphocysteine intermediateBy similarity1
Binding sitei886SubstrateBy similarity1
Active sitei1157Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase CCurated (EC:3.1.3.48)
Alternative name(s):
Leukocyte common antigen
Short name:
L-CA
Lymphocyte antigen 5
Short name:
Ly-5
T200
CD_antigen: CD45
Gene namesi
Name:PtprcImported
Synonyms:Ly-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:97810 Ptprc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 566ExtracellularSequence analysisAdd BLAST541
Transmembranei567 – 588HelicalSequence analysisAdd BLAST22
Topological domaini589 – 1293CytoplasmicSequence analysisAdd BLAST705

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Add BLAST25
ChainiPRO_000002547126 – 1293Receptor-type tyrosine-protein phosphatase CAdd BLAST1268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi209N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi255N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi292N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi313N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi324N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi349N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi418N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi429N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi459N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi491N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei672PhosphotyrosineBy similarity1
Modified residuei964PhosphoserineCombined sources1
Modified residuei983PhosphoserineBy similarity1
Modified residuei986PhosphoserineBy similarity1
Modified residuei990PhosphoserineBy similarity1
Modified residuei993PhosphoserineBy similarity1
Modified residuei994PhosphoserineCombined sources1
Modified residuei998PhosphoserineBy similarity1
Modified residuei1229PhosphoserineBy similarity1
Modified residuei1267PhosphothreonineCombined sources1
Modified residuei1286PhosphoserineCombined sources1

Post-translational modificationi

Heavily N- and O-glycosylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP06800
PeptideAtlasiP06800
PRIDEiP06800

PTM databases

iPTMnetiP06800
PhosphoSitePlusiP06800
SwissPalmiP06800

Expressioni

Developmental stagei

Expression is restricted to the hematopoietic compartment of development.

Gene expression databases

BgeeiENSMUSG00000026395 Expressed in 199 organ(s), highest expression level in spleen
CleanExiMM_PTPRC

Interactioni

Subunit structurei

Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes (By similarity). Binds GANAB and PRKCSH.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
LckP062402EBI-1672,EBI-1401

GO - Molecular functioni

Protein-protein interaction databases

IntActiP06800, 11 interactors
MINTiP06800
STRINGi10090.ENSMUSP00000027645

Structurei

3D structure databases

ProteinModelPortaliP06800
SMRiP06800
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini376 – 472Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST97
Domaini473 – 568Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini642 – 901Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST260
Domaini933 – 1216Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST284

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni842 – 848Substrate bindingBy similarity7

Domaini

The first PTPase domain interacts with SKAP1.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4228 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00760000118900
HOVERGENiHBG000066
InParanoidiP06800
KOiK06478
OMAiQYQYNNW
OrthoDBiEOG091G015A
TreeFamiTF351829

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 2 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR024739 PTP_recept_N
IPR000242 PTPase_domain
IPR016335 Ptprc
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF12567 CD45, 1 hit
PF12453 PTP_N, 1 hit
PF00102 Y_phosphatase, 2 hits
PIRSFiPIRSF002004 Leukocyte_common_antigen, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF49265 SSF49265, 2 hits
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P06800-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTMGLWLKLL AFGFALLDTE VFVTGQTPTP SDELSTTENA LLLPQSDPLP
60 70 80 90 100
ARTTESTPPS ISERGNGSSE TTYHPGVLST LLPHLSPQPD SQTPSAGGAD
110 120 130 140 150
TQTFSSQADN PTLTPAPGGG TDPPGVPGER TVPGTIPADT AFPVDTPSLA
160 170 180 190 200
RNSSAASPTH TSNVSTTDIS SGASLTTLTP STLGLASTDP PSTTIATTTK
210 220 230 240 250
QTCAAMFGNI TVNYTYESSN QTFKADLKDV QNAKCGNEDC ENVLNNLEEC
260 270 280 290 300
SQIKNISVSN DSCAPATTID LYVPPGTDKF SLHDCTPKEK ANTSICLEWK
310 320 330 340 350
TKNLDFRKCN SDNISYVLHC EPENNTKCIR RNTFIPERCQ LDNLRAQTNY
360 370 380 390 400
TCVAEILYRG VKLVKNVINV QTDLGIPETP KPSCGDPAAR KTLVSWPEPV
410 420 430 440 450
SKPESASKPH GYVLCYKNNS EKCKSLPNNV TSFEVESLKP YKYYEVSLLA
460 470 480 490 500
YVNGKIQRNG TAEKCNFHTK ADRPDKVNGM KTSRPTDNSI NVTCGPPYET
510 520 530 540 550
NGPKTFYILV VRSGGSFVTK YNKTNCQFYV DNLYYSTDYE FLVSFHNGVY
560 570 580 590 600
EGDSVIRNES TNFNAKALII FLVFLIIVTS IALLVVLYKI YDLRKKRSSN
610 620 630 640 650
LDEQQELVER DDEKQLMDVE PIHSDILLET YKRKIADEGR LFLAEFQSIP
660 670 680 690 700
RVFSKFPIKD ARKPHNQNKN RYVDILPYDY NRVELSEING DAGSTYINAS
710 720 730 740 750
YIDGFKEPRK YIAAQGPRDE TVDDFWRMIW EQKATVIVMV TRCEEGNRNK
760 770 780 790 800
CAEYWPSMEE GTRAFKDIVV TINDHKRCPD YIIQKLNVAH KKEKATGREV
810 820 830 840 850
THIQFTSWPD HGVPEDPHLL LKLRRRVNAF SNFFSGPIVV HCSAGVGRTG
860 870 880 890 900
TYIGIDAMLE GLEAEGKVDV YGYVVKLRRQ RCLMVQVEAQ YILIHQALVE
910 920 930 940 950
YNQFGETEVN LSELHSCLHN MKKRDPPSDP SPLEAEYQRL PSYRSWRTQH
960 970 980 990 1000
IGNQEENKKK NRNSNVVPYD FNRVPLKHEL EMSKESEPES DESSDDDSDS
1010 1020 1030 1040 1050
EETSKYINAS FVMSYWKPEM MIAAQGPLKE TIGDFWQMIF QRKVKVIVML
1060 1070 1080 1090 1100
TELVNGDQEV CAQYWGEGKQ TYGDMEVEMK DTNRASAYTL RTFELRHSKR
1110 1120 1130 1140 1150
KEPRTVYQYQ CTTWKGEELP AEPKDLVSMI QDLKQKLPKA SPEGMKYHKH
1160 1170 1180 1190 1200
ASILVHCRDG SQQTGLFCAL FNLLESAETE DVVDVFQVVK SLRKARPGVV
1210 1220 1230 1240 1250
CSYEQYQFLY DIIASIYPAQ NGQVKKTNSQ DKIEFHNEVD GGKQDANCVR
1260 1270 1280 1290
PDGPLNKAQE DSRGVGTPEP TNSAEEPEHA ANGSASPAPT QSS
Length:1,293
Mass (Da):144,837
Last modified:March 28, 2018 - v4
Checksum:i44C3D35121181B31
GO
Isoform 2 (identifier: P06800-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-75: Missing.

Show »
Length:1,250
Mass (Da):140,272
Checksum:iEDC7195D35923C29
GO
Isoform 3 (identifier: P06800-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-171: Missing.

Show »
Length:1,154
Mass (Da):130,855
Checksum:iBDFF3E12E270B07D
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R1M0S4R1M0_MOUSE
Receptor-type tyrosine-protein phos...
Ptprc
1,130Annotation score:
A0A0A6YXM4A0A0A6YXM4_MOUSE
Receptor-type tyrosine-protein phos...
Ptprc
212Annotation score:
A0A0A6YWF2A0A0A6YWF2_MOUSE
Receptor-type tyrosine-protein phos...
Ptprc
94Annotation score:

Sequence cautioni

The sequence AAA39458 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA39459 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA40161 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAA40161 differs from that shown. Reason: Frameshift at position 969.Curated
The sequence AAA60449 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAB46374 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti302K → E in AAA39459 (PubMed:1822988).Curated1
Sequence conflicti400 – 405VSKPES → ASKPDP in AAA39459 (PubMed:1822988).Curated6
Sequence conflicti478N → T in AAA39459 (PubMed:1822988).Curated1
Sequence conflicti530V → G in AAA39458 (PubMed:2944116).Curated1
Sequence conflicti558N → S in AAA39458 (PubMed:2944116).Curated1
Sequence conflicti590I → S in AAA39458 (PubMed:2944116).Curated1
Sequence conflicti908E → Q in AAA39458 (PubMed:2944116).Curated1
Sequence conflicti933L → R in AAA39458 (PubMed:2944116).Curated1
Sequence conflicti955E → G in AAA39458 (PubMed:2944116).Curated1
Sequence conflicti961N → K in AAA39458 (PubMed:2944116).Curated1
Sequence conflicti966 – 969VVPY → CSID in AAA40161 (PubMed:2948186).Curated4

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05941033 – 171Missing in isoform 3. Add BLAST139
Alternative sequenceiVSP_05941133 – 75Missing in isoform 2. Add BLAST43

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14342 mRNA Translation: AAA39458.1 Different initiation.
M92933 mRNA Translation: AAA39459.1 Different initiation.
AC122903 Genomic DNA No translation available.
AC159278 Genomic DNA No translation available.
CH466520 Genomic DNA Translation: EDL39542.1
M17320 mRNA Translation: AAA60449.1 Different initiation.
M23354 Genomic DNA Translation: AAA39462.1
M22456 Genomic DNA Translation: AAB46374.1 Different initiation.
M11934 mRNA Translation: AAA39461.1
M23241 Genomic DNA Translation: AAA39460.1
M15174 mRNA Translation: AAA40161.1 Sequence problems.
CCDSiCCDS15330.2 [P06800-6]
CCDS48383.2 [P06800-4]
PIRiA23329
A28334
A28335
I57644
RefSeqiNP_001104786.2, NM_001111316.2 [P06800-4]
NP_035340.3, NM_011210.4 [P06800-6]
XP_006529320.1, XM_006529257.1 [P06800-4]
XP_006529321.1, XM_006529258.3 [P06800-4]
XP_006529322.1, XM_006529259.3 [P06800-4]
XP_006529323.1, XM_006529260.1 [P06800-5]
UniGeneiMm.391573

Genome annotation databases

EnsembliENSMUST00000182283; ENSMUSP00000138800; ENSMUSG00000026395 [P06800-6]
ENSMUST00000183301; ENSMUSP00000138350; ENSMUSG00000026395 [P06800-4]
GeneIDi19264
KEGGimmu:19264
UCSCiuc007cvf.3 mouse [P06800-4]
uc007cvh.3 mouse

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14342 mRNA Translation: AAA39458.1 Different initiation.
M92933 mRNA Translation: AAA39459.1 Different initiation.
AC122903 Genomic DNA No translation available.
AC159278 Genomic DNA No translation available.
CH466520 Genomic DNA Translation: EDL39542.1
M17320 mRNA Translation: AAA60449.1 Different initiation.
M23354 Genomic DNA Translation: AAA39462.1
M22456 Genomic DNA Translation: AAB46374.1 Different initiation.
M11934 mRNA Translation: AAA39461.1
M23241 Genomic DNA Translation: AAA39460.1
M15174 mRNA Translation: AAA40161.1 Sequence problems.
CCDSiCCDS15330.2 [P06800-6]
CCDS48383.2 [P06800-4]
PIRiA23329
A28334
A28335
I57644
RefSeqiNP_001104786.2, NM_001111316.2 [P06800-4]
NP_035340.3, NM_011210.4 [P06800-6]
XP_006529320.1, XM_006529257.1 [P06800-4]
XP_006529321.1, XM_006529258.3 [P06800-4]
XP_006529322.1, XM_006529259.3 [P06800-4]
XP_006529323.1, XM_006529260.1 [P06800-5]
UniGeneiMm.391573

3D structure databases

ProteinModelPortaliP06800
SMRiP06800
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP06800, 11 interactors
MINTiP06800
STRINGi10090.ENSMUSP00000027645

PTM databases

iPTMnetiP06800
PhosphoSitePlusiP06800
SwissPalmiP06800

Proteomic databases

PaxDbiP06800
PeptideAtlasiP06800
PRIDEiP06800

Protocols and materials databases

DNASUi19264
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000182283; ENSMUSP00000138800; ENSMUSG00000026395 [P06800-6]
ENSMUST00000183301; ENSMUSP00000138350; ENSMUSG00000026395 [P06800-4]
GeneIDi19264
KEGGimmu:19264
UCSCiuc007cvf.3 mouse [P06800-4]
uc007cvh.3 mouse

Organism-specific databases

CTDi5788
MGIiMGI:97810 Ptprc

Phylogenomic databases

eggNOGiKOG4228 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00760000118900
HOVERGENiHBG000066
InParanoidiP06800
KOiK06478
OMAiQYQYNNW
OrthoDBiEOG091G015A
TreeFamiTF351829

Miscellaneous databases

PROiPR:P06800
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026395 Expressed in 199 organ(s), highest expression level in spleen
CleanExiMM_PTPRC

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.60.40.10, 2 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR024739 PTP_recept_N
IPR000242 PTPase_domain
IPR016335 Ptprc
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF12567 CD45, 1 hit
PF12453 PTP_N, 1 hit
PF00102 Y_phosphatase, 2 hits
PIRSFiPIRSF002004 Leukocyte_common_antigen, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 2 hits
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF49265 SSF49265, 2 hits
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 2 hits
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRC_MOUSE
AccessioniPrimary (citable) accession number: P06800
Secondary accession number(s): E9QLT5
, Q61812, Q61813, Q61814, Q61815, Q78EF1, S4R1S4, S4R2V1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: March 28, 2018
Last modified: November 7, 2018
This is version 196 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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