Receptor-type tyrosine-protein phosphatase C

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

• H₂O

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  + O-phospho-L-tyrosyl-[protein]

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  = L-tyrosyl-[protein]

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  + phosphate

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  PROSITE-ProRule annotation

  <p>Manual validated information which has been generated by the UniProtKB automatic annotation system.</p> <p><a href="/manual/evidences#ECO:0000255">More...</a></p> Manual assertion according to rulesⁱ

  • PROSITE-ProRule:PRU10044
  EC:3.1.3.48
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  • See the description of this EC number in ENZYME.
  PROSITE-ProRule annotation

  Manual assertion according to rulesⁱ

  • PROSITE-ProRule:PRU10044
  Source: Rhea

  • Search for this reaction in UniProtKB.
  • See the description of this reaction in Rhea.

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  H₂O

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  • See the description of this molecule in ChEBI.

  

  +

  O-phospho-L-tyrosyl-[protein]

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  • Search chemical reactions in Rhea for this molecule.

  

  L-tyrosine-phosphate residue

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  zoom

  =

  L-tyrosyl-[protein]

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  L-tyrosine residue

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  +

  phosphate

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Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ankyrin binding Source: MGI
• heparan sulfate proteoglycan binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfate."
    Coombe D.R., Watt S.M., Parish C.R.
    Blood 84:739-752(1994) [PubMed] [Europe PMC] [Abstract]
• heparin binding Source: MGIInferred from direct assayⁱ
  • "Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfate."
    Coombe D.R., Watt S.M., Parish C.R.
    Blood 84:739-752(1994) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling."
    Irie-Sasaki J., Sasaki T., Matsumoto W., Opavsky A., Cheng M., Welstead G., Griffiths E., Krawczyk C., Richardson C.D., Aitken K., Iscove N., Koretzky G., Johnson P., Liu P., Rothstein D.M., Penninger J.M.
    Nature 409:349-354(2001) [PubMed] [Europe PMC] [Abstract]
• protein tyrosine phosphatase activity Source: MGIInferred from direct assayⁱ
  • "Zinc transporter SLC39A10/ZIP10 controls humoral immunity by modulating B-cell receptor signal strength."
    Hojyo S., Miyai T., Fujishiro H., Kawamura M., Yasuda T., Hijikata A., Bin B.H., Irie T., Tanaka J., Atsumi T., Murakami M., Nakayama M., Ohara O., Himeno S., Yoshida H., Koseki H., Ikawa T., Mishima K., Fukada T.
    Proc Natl Acad Sci U S A 111:11786-11791(2014) [PubMed] [Europe PMC] [Abstract]
  • "Involvement of CD45 in adhesion and suppression of apoptosis of mouse malignant T-lymphoma cells."
    Hanaoka K., Fujita N., Lee S.H., Seimiya H., Naito M., Tsuruo T.
    Cancer Res 55:2186-2190(1995) [PubMed] [Europe PMC] [Abstract]
  • "Detection of restricted isoform expression and tyrosine phosphatase activity of CD45 in murine dendritic cells."
    Haidl I.D., Ng D.H., Rothenberger S., Johnson P., Jefferies W.A.
    Eur J Immunol 25:3370-3374(1995) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: ARUK-UCLInferred from physical interactionⁱ
  • "Comparison of CD22 binding to native CD45 and synthetic oligosaccharide."
    Bakker T.R., Piperi C., Davies E.A., Merwe P.A.
    Eur J Immunol 32:1924-1932(2002) [PubMed] [Europe PMC] [Abstract]
• spectrin binding Source: MGI

GO - Biological processⁱ

• activation of MAPK activity Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The motheaten mutation rescues B cell signaling and development in CD45-deficient mice."
    Pani G., Siminovitch K.A., Paige C.J.
    J Exp Med 186:581-588(1997) [PubMed] [Europe PMC] [Abstract]
• B cell differentiation Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Phenotypical and functional alterations in the mucosal immune system of CD45 exon 9 KO mice."
    Lopez M.C., Holmes N.
    Int Immunol 17:15-25(2005) [PubMed] [Europe PMC] [Abstract]
  • "Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling."
    Zhu J.W., Brdicka T., Katsumoto T.R., Lin J., Weiss A.
    Immunity 28:183-196(2008) [PubMed] [Europe PMC] [Abstract]
• B cell proliferation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice."
    Kishihara K., Penninger J., Wallace V.A., Kundig T.M., Kawai K., Wakeham A., Timms E., Pfeffer K., Ohashi P.S., Thomas M.L.
    Cell 74:143-156(1993) [PubMed] [Europe PMC] [Abstract]
• B cell receptor signaling pathway Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45."
    Cyster J.G., Healy J.I., Kishihara K., Mak T.W., Thomas M.L., Goodnow C.C.
    Nature 381:325-328(1996) [PubMed] [Europe PMC] [Abstract]
• bone marrow development Source: MGI
• calcium-mediated signaling using intracellular calcium source Source: ARUK-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling."
    Zhu J.W., Brdicka T., Katsumoto T.R., Lin J., Weiss A.
    Immunity 28:183-196(2008) [PubMed] [Europe PMC] [Abstract]
• cell cycle phase transition Source: MGI
• cellular response to extracellular stimulus Source: ARUK-UCLInferred from genetic interactionⁱ
  • "CD45 signals outside of lipid rafts to promote ERK activation, synaptic raft clustering, and IL-2 production."
    Zhang M., Moran M., Round J., Low T.A., Patel V.P., Tomassian T., Hernandez J.D., Miceli M.C.
    J Immunol 174:1479-1490(2005) [PubMed] [Europe PMC] [Abstract]
• defense response to virus Source: MGIInferred from direct assayⁱ
  • "Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN."
    Hervas-Stubbs S., Rueda P., Lopez L., Leclerc C.
    J Immunol 178:2361-2369(2007) [PubMed] [Europe PMC] [Abstract]
• dephosphorylation Source: UniProtKBInferred from direct assayⁱ
  • "CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling."
    Irie-Sasaki J., Sasaki T., Matsumoto W., Opavsky A., Cheng M., Welstead G., Griffiths E., Krawczyk C., Richardson C.D., Aitken K., Iscove N., Koretzky G., Johnson P., Liu P., Rothstein D.M., Penninger J.M.
    Nature 409:349-354(2001) [PubMed] [Europe PMC] [Abstract]
• hematopoietic progenitor cell differentiation Source: MGI
• heterotypic cell-cell adhesion Source: MGIInferred from mutant phenotypeⁱ
  • "Involvement of CD45 in adhesion and suppression of apoptosis of mouse malignant T-lymphoma cells."
    Hanaoka K., Fujita N., Lee S.H., Seimiya H., Naito M., Tsuruo T.
    Cancer Res 55:2186-2190(1995) [PubMed] [Europe PMC] [Abstract]
• leukocyte cell-cell adhesion Source: MGIInferred from mutant phenotypeⁱ
  • "Involvement of CD45 in adhesion and suppression of apoptosis of mouse malignant T-lymphoma cells."
    Hanaoka K., Fujita N., Lee S.H., Seimiya H., Naito M., Tsuruo T.
    Cancer Res 55:2186-2190(1995) [PubMed] [Europe PMC] [Abstract]
• natural killer cell differentiation Source: ARUK-UCLInferred from mutant phenotypeⁱ
  • "Phenotypical and functional alterations in the mucosal immune system of CD45 exon 9 KO mice."
    Lopez M.C., Holmes N.
    Int Immunol 17:15-25(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell adhesion involved in substrate-bound cell migration Source: MGI
• negative regulation of cytokine-mediated signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • "CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling."
    Irie-Sasaki J., Sasaki T., Matsumoto W., Opavsky A., Cheng M., Welstead G., Griffiths E., Krawczyk C., Richardson C.D., Aitken K., Iscove N., Koretzky G., Johnson P., Liu P., Rothstein D.M., Penninger J.M.
    Nature 409:349-354(2001) [PubMed] [Europe PMC] [Abstract]
• negative regulation of ERK1 and ERK2 cascade Source: ARUK-UCLInferred from genetic interactionⁱ
  • "CD45 signals outside of lipid rafts to promote ERK activation, synaptic raft clustering, and IL-2 production."
    Zhang M., Moran M., Round J., Low T.A., Patel V.P., Tomassian T., Hernandez J.D., Miceli M.C.
    J Immunol 174:1479-1490(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of interleukin-2 production Source: ARUK-UCLInferred from genetic interactionⁱ
  • "CD45 signals outside of lipid rafts to promote ERK activation, synaptic raft clustering, and IL-2 production."
    Zhang M., Moran M., Round J., Low T.A., Patel V.P., Tomassian T., Hernandez J.D., Miceli M.C.
    J Immunol 174:1479-1490(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of peptidyl-tyrosine phosphorylation Source: MGIInferred from mutant phenotypeⁱ
  • "Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells."
    Katagiri T., Ogimoto M., Hasegawa K., Mizuno K., Yakura H.
    J Biol Chem 270:27987-27990(1995) [PubMed] [Europe PMC] [Abstract]
  • "CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases."
    Burns C.M., Sakaguchi K., Appella E., Ashwell J.D.
    J Biol Chem 269:13594-13600(1994) [PubMed] [Europe PMC] [Abstract]
• negative regulation of protein autophosphorylation Source: MGIInferred from mutant phenotypeⁱ
  • "Selective regulation of Lyn tyrosine kinase by CD45 in immature B cells."
    Katagiri T., Ogimoto M., Hasegawa K., Mizuno K., Yakura H.
    J Biol Chem 270:27987-27990(1995) [PubMed] [Europe PMC] [Abstract]
  • "CD45 regulation of tyrosine phosphorylation and enzyme activity of src family kinases."
    Burns C.M., Sakaguchi K., Appella E., Ashwell J.D.
    J Biol Chem 269:13594-13600(1994) [PubMed] [Europe PMC] [Abstract]
• negative regulation of protein kinase activity Source: UniProtKBInferred from direct assayⁱ
  • "Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice."
    Baker M., Gamble J., Tooze R., Higgins D., Yang F.T., O'Brien P.C., Coleman N., Pingel S., Turner M., Alexander D.R.
    EMBO J 19:4644-4654(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of protein tyrosine kinase activity Source: ARUK-UCLInferred from genetic interactionⁱ
  • "CD45 signals outside of lipid rafts to promote ERK activation, synaptic raft clustering, and IL-2 production."
    Zhang M., Moran M., Round J., Low T.A., Patel V.P., Tomassian T., Hernandez J.D., Miceli M.C.
    J Immunol 174:1479-1490(2005) [PubMed] [Europe PMC] [Abstract]
• negative regulation of T cell mediated cytotoxicity Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Differential requirements of CD45 protein tyrosine phosphatase for cytolytic activities and intrathymic and extrathymic development of intestinal intraepithelial lymphocytes."
    Yada S., Kishihara K., Kong Y.Y., Nomoto K.
    J Immunol 161:2208-2216(1998) [PubMed] [Europe PMC] [Abstract]
• negative thymic T cell selection Source: MGIInferred from mutant phenotypeⁱ
  • "CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation."
    Byth K.F., Conroy L.A., Howlett S., Smith A.J., May J., Alexander D.R., Holmes N.
    J Exp Med 183:1707-1718(1996) [PubMed] [Europe PMC] [Abstract]
• plasma membrane raft distribution Source: ARUK-UCLInferred from genetic interactionⁱ
  • "CD45 signals outside of lipid rafts to promote ERK activation, synaptic raft clustering, and IL-2 production."
    Zhang M., Moran M., Round J., Low T.A., Patel V.P., Tomassian T., Hernandez J.D., Miceli M.C.
    J Immunol 174:1479-1490(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of alpha-beta T cell proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "Generation of T cells with differential responses to alloantigens in CD45 exon 6-deficient mice."
    Kong Y.Y., Kishihara K., Yoshida H., Mak T.W., Nomoto K.
    J Immunol 154:5725-5735(1995) [PubMed] [Europe PMC] [Abstract]
• positive regulation of antigen receptor-mediated signaling pathway Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45."
    Cyster J.G., Healy J.I., Kishihara K., Mak T.W., Thomas M.L., Goodnow C.C.
    Nature 381:325-328(1996) [PubMed] [Europe PMC] [Abstract]
• positive regulation of B cell proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "Differential requirements of CD45 for lymphocyte development and function."
    Kong Y.Y., Kishihara K., Sumichika H., Nakamura T., Kaneko M., Nomoto K.
    Eur J Immunol 25:3431-3436(1995) [PubMed] [Europe PMC] [Abstract]
  • "CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation."
    Byth K.F., Conroy L.A., Howlett S., Smith A.J., May J., Alexander D.R., Holmes N.
    J Exp Med 183:1707-1718(1996) [PubMed] [Europe PMC] [Abstract]
  • "T-cell-independent antiviral B cell responses in CD45-deficient mice."
    Bachmann M.F., Kundig T.M., Speiser D.E., McKall-Faienza K., Kishara K., Mak T.W., Ohashi P.S.
    Cell Immunol 175:12-15(1997) [PubMed] [Europe PMC] [Abstract]
  • "The motheaten mutation rescues B cell signaling and development in CD45-deficient mice."
    Pani G., Siminovitch K.A., Paige C.J.
    J Exp Med 186:581-588(1997) [PubMed] [Europe PMC] [Abstract]
• positive regulation of ERK1 and ERK2 cascade Source: ARUK-UCLInferred from genetic interactionⁱ
  • "CD45 signals outside of lipid rafts to promote ERK activation, synaptic raft clustering, and IL-2 production."
    Zhang M., Moran M., Round J., Low T.A., Patel V.P., Tomassian T., Hernandez J.D., Miceli M.C.
    J Immunol 174:1479-1490(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of extrinsic apoptotic signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • "CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation."
    Byth K.F., Conroy L.A., Howlett S., Smith A.J., May J., Alexander D.R., Holmes N.
    J Exp Med 183:1707-1718(1996) [PubMed] [Europe PMC] [Abstract]
• positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling."
    Zhu J.W., Brdicka T., Katsumoto T.R., Lin J., Weiss A.
    Immunity 28:183-196(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gamma-delta T cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Impaired development of V gamma 3 dendritic epidermal T cells in p56lck protein tyrosine kinase-deficient and CD45 protein tyrosine phosphatase-deficient mice."
    Kawai K., Kishihara K., Molina T.J., Wallace V.A., Mak T.W., Ohashi P.S.
    J Exp Med 181:345-349(1995) [PubMed] [Europe PMC] [Abstract]
• positive regulation of hematopoietic stem cell migration Source: MGI
• positive regulation of humoral immune response mediated by circulating immunoglobulin Source: MGIInferred from mutant phenotypeⁱ
  • "Differential requirements of CD45 for lymphocyte development and function."
    Kong Y.Y., Kishihara K., Sumichika H., Nakamura T., Kaneko M., Nomoto K.
    Eur J Immunol 25:3431-3436(1995) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-2 production Source: ARUK-UCLInferred from genetic interactionⁱ
  • "CD45 signals outside of lipid rafts to promote ERK activation, synaptic raft clustering, and IL-2 production."
    Zhang M., Moran M., Round J., Low T.A., Patel V.P., Tomassian T., Hernandez J.D., Miceli M.C.
    J Immunol 174:1479-1490(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of isotype switching to IgG isotypes Source: MGIInferred from mutant phenotypeⁱ
  • "T-cell-independent antiviral B cell responses in CD45-deficient mice."
    Bachmann M.F., Kundig T.M., Speiser D.E., McKall-Faienza K., Kishara K., Mak T.W., Ohashi P.S.
    Cell Immunol 175:12-15(1997) [PubMed] [Europe PMC] [Abstract]
• positive regulation of MAPK cascade Source: MGIInferred from mutant phenotypeⁱ
  • "The motheaten mutation rescues B cell signaling and development in CD45-deficient mice."
    Pani G., Siminovitch K.A., Paige C.J.
    J Exp Med 186:581-588(1997) [PubMed] [Europe PMC] [Abstract]
• positive regulation of peptidyl-tyrosine phosphorylation Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling."
    Zhu J.W., Brdicka T., Katsumoto T.R., Lin J., Weiss A.
    Immunity 28:183-196(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of protein tyrosine phosphatase activity Source: ARUK-UCLInferred from genetic interactionⁱ
  • "CD45 signals outside of lipid rafts to promote ERK activation, synaptic raft clustering, and IL-2 production."
    Zhang M., Moran M., Round J., Low T.A., Patel V.P., Tomassian T., Hernandez J.D., Miceli M.C.
    J Immunol 174:1479-1490(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of stem cell proliferation Source: MGI
• positive regulation of T cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation."
    Byth K.F., Conroy L.A., Howlett S., Smith A.J., May J., Alexander D.R., Holmes N.
    J Exp Med 183:1707-1718(1996) [PubMed] [Europe PMC] [Abstract]
• positive regulation of T cell mediated cytotoxicity Source: MGIInferred from mutant phenotypeⁱ
  • "Inhibition of T cell responses to alloantigens and polyclonal mitogens by Ly-5 antisera."
    Harp J.A., Davis B.S., Ewald S.J.
    J Immunol 133:10-15(1984) [PubMed] [Europe PMC] [Abstract]
• positive regulation of T cell mediated immunity Source: MGIInferred from mutant phenotypeⁱ
  • "Inhibition of T cell responses to alloantigens and polyclonal mitogens by Ly-5 antisera."
    Harp J.A., Davis B.S., Ewald S.J.
    J Immunol 133:10-15(1984) [PubMed] [Europe PMC] [Abstract]
  • "Differential requirements of CD45 for lymphocyte development and function."
    Kong Y.Y., Kishihara K., Sumichika H., Nakamura T., Kaneko M., Nomoto K.
    Eur J Immunol 25:3431-3436(1995) [PubMed] [Europe PMC] [Abstract]
• positive regulation of T cell proliferation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice."
    Kishihara K., Penninger J., Wallace V.A., Kundig T.M., Kawai K., Wakeham A., Timms E., Pfeffer K., Ohashi P.S., Thomas M.L.
    Cell 74:143-156(1993) [PubMed] [Europe PMC] [Abstract]
• positive regulation of tumor necrosis factor production Source: ARUK-UCLInferred from genetic interactionⁱ
  • "Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling."
    Zhu J.W., Brdicka T., Katsumoto T.R., Lin J., Weiss A.
    Immunity 28:183-196(2008) [PubMed] [Europe PMC] [Abstract]
• positive thymic T cell selection Source: MGIInferred from mutant phenotypeⁱ
  • "CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation."
    Byth K.F., Conroy L.A., Howlett S., Smith A.J., May J., Alexander D.R., Holmes N.
    J Exp Med 183:1707-1718(1996) [PubMed] [Europe PMC] [Abstract]
• protein dephosphorylation Source: UniProtKBInferred from direct assayⁱ
  • "CD45 regulates Src family member kinase activity associated with macrophage integrin-mediated adhesion."
    Roach T., Slater S., Koval M., White L., Cahir McFarland E.D., Okumura M., Thomas M., Brown E.
    Curr Biol 7:408-417(1997) [PubMed] [Europe PMC] [Abstract]
• regulation of cell cycle Source: UniProtKBInferred from direct assayⁱ
  • "Development of T-leukaemias in CD45 tyrosine phosphatase-deficient mutant lck mice."
    Baker M., Gamble J., Tooze R., Higgins D., Yang F.T., O'Brien P.C., Coleman N., Pingel S., Turner M., Alexander D.R.
    EMBO J 19:4644-4654(2000) [PubMed] [Europe PMC] [Abstract]
• regulation of extrinsic apoptotic signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • "Involvement of CD45 in adhesion and suppression of apoptosis of mouse malignant T-lymphoma cells."
    Hanaoka K., Fujita N., Lee S.H., Seimiya H., Naito M., Tsuruo T.
    Cancer Res 55:2186-2190(1995) [PubMed] [Europe PMC] [Abstract]
• regulation of gene expression Source: ARUK-UCLInferred from genetic interactionⁱ
  • "CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling."
    Irles C., Symons A., Michel F., Bakker T.R., van der Merwe P.A., Acuto O.
    Nat Immunol 4:189-197(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of humoral immune response mediated by circulating immunoglobulin Source: MGIInferred from mutant phenotypeⁱ
  • "T-cell-independent antiviral B cell responses in CD45-deficient mice."
    Bachmann M.F., Kundig T.M., Speiser D.E., McKall-Faienza K., Kishara K., Mak T.W., Ohashi P.S.
    Cell Immunol 175:12-15(1997) [PubMed] [Europe PMC] [Abstract]
• regulation of interleukin-8 production Source: MGI
• regulation of phagocytosis Source: MGI
• regulation of protein tyrosine kinase activity Source: MGI
• regulation of receptor signaling pathway via JAK-STAT Source: MGI
• release of sequestered calcium ion into cytosol Source: UniProtKBInferred from direct assayⁱ
  • "Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase-deficient mice."
    Mee P.J., Turner M., Basson M.A., Costello P.S., Zamoyska R., Tybulewicz V.L.
    Eur J Immunol 29:2923-2933(1999) [PubMed] [Europe PMC] [Abstract]
• response to gamma radiation Source: MGI
• stem cell development Source: MGI
• T cell differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice."
    Kishihara K., Penninger J., Wallace V.A., Kundig T.M., Kawai K., Wakeham A., Timms E., Pfeffer K., Ohashi P.S., Thomas M.L.
    Cell 74:143-156(1993) [PubMed] [Europe PMC] [Abstract]
• T cell proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "Either of the CD45RB and CD45RO isoforms are effective in restoring T cell, but not B cell, development and function in CD45-null mice."
    Ogilvy S., Louis-Dit-Sully C., Cooper J., Cassady R.L., Alexander D.R., Holmes N.
    J Immunol 171:1792-1800(2003) [PubMed] [Europe PMC] [Abstract]
• T cell receptor signaling pathway Source: ARUK-UCLInferred from genetic interactionⁱ
  • "CD45 ectodomain controls interaction with GEMs and Lck activity for optimal TCR signaling."
    Irles C., Symons A., Michel F., Bakker T.R., van der Merwe P.A., Acuto O.
    Nat Immunol 4:189-197(2003) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• ankyrin binding Source: MGI
• heparan sulfate proteoglycan binding Source: MGIInferred from direct assayⁱ
  • "Mac-1 (CD11b/CD18) and CD45 mediate the adhesion of hematopoietic progenitor cells to stromal cell elements via recognition of stromal heparan sulfate."
    Coombe D.R., Watt S.M., Parish C.R.
    Blood 84:739-752(1994) [PubMed] [Europe PMC] [Abstract]
• protein kinase binding Source: UniProtKBInferred from physical interactionⁱ
  • "CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling."
    Irie-Sasaki J., Sasaki T., Matsumoto W., Opavsky A., Cheng M., Welstead G., Griffiths E., Krawczyk C., Richardson C.D., Aitken K., Iscove N., Koretzky G., Johnson P., Liu P., Rothstein D.M., Penninger J.M.
    Nature 409:349-354(2001) [PubMed] [Europe PMC] [Abstract]
• signaling receptor binding Source: ARUK-UCLInferred from physical interactionⁱ
  • "Comparison of CD22 binding to native CD45 and synthetic oligosaccharide."
    Bakker T.R., Piperi C., Davies E.A., Merwe P.A.
    Eur J Immunol 32:1924-1932(2002) [PubMed] [Europe PMC] [Abstract]
• spectrin binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MTMGLWLKLL AFGFALLDTE VFVTGQTPTP SDELSTTENA LLLPQSDPLP 
        60         70         80         90        100
ARTTESTPPS ISERGNGSSE TTYHPGVLST LLPHLSPQPD SQTPSAGGAD 
       110        120        130        140        150
TQTFSSQADN PTLTPAPGGG TDPPGVPGER TVPGTIPADT AFPVDTPSLA 
       160        170        180        190        200
RNSSAASPTH TSNVSTTDIS SGASLTTLTP STLGLASTDP PSTTIATTTK 
       210        220        230        240        250
QTCAAMFGNI TVNYTYESSN QTFKADLKDV QNAKCGNEDC ENVLNNLEEC 
       260        270        280        290        300
SQIKNISVSN DSCAPATTID LYVPPGTDKF SLHDCTPKEK ANTSICLEWK 
       310        320        330        340        350
TKNLDFRKCN SDNISYVLHC EPENNTKCIR RNTFIPERCQ LDNLRAQTNY 
       360        370        380        390        400
TCVAEILYRG VKLVKNVINV QTDLGIPETP KPSCGDPAAR KTLVSWPEPV 
       410        420        430        440        450
SKPESASKPH GYVLCYKNNS EKCKSLPNNV TSFEVESLKP YKYYEVSLLA 
       460        470        480        490        500
YVNGKIQRNG TAEKCNFHTK ADRPDKVNGM KTSRPTDNSI NVTCGPPYET 
       510        520        530        540        550
NGPKTFYILV VRSGGSFVTK YNKTNCQFYV DNLYYSTDYE FLVSFHNGVY 
       560        570        580        590        600
EGDSVIRNES TNFNAKALII FLVFLIIVTS IALLVVLYKI YDLRKKRSSN 
       610        620        630        640        650
LDEQQELVER DDEKQLMDVE PIHSDILLET YKRKIADEGR LFLAEFQSIP 
       660        670        680        690        700
RVFSKFPIKD ARKPHNQNKN RYVDILPYDY NRVELSEING DAGSTYINAS 
       710        720        730        740        750
YIDGFKEPRK YIAAQGPRDE TVDDFWRMIW EQKATVIVMV TRCEEGNRNK 
       760        770        780        790        800
CAEYWPSMEE GTRAFKDIVV TINDHKRCPD YIIQKLNVAH KKEKATGREV 
       810        820        830        840        850
THIQFTSWPD HGVPEDPHLL LKLRRRVNAF SNFFSGPIVV HCSAGVGRTG 
       860        870        880        890        900
TYIGIDAMLE GLEAEGKVDV YGYVVKLRRQ RCLMVQVEAQ YILIHQALVE 
       910        920        930        940        950
YNQFGETEVN LSELHSCLHN MKKRDPPSDP SPLEAEYQRL PSYRSWRTQH 
       960        970        980        990       1000
IGNQEENKKK NRNSNVVPYD FNRVPLKHEL EMSKESEPES DESSDDDSDS 
      1010       1020       1030       1040       1050
EETSKYINAS FVMSYWKPEM MIAAQGPLKE TIGDFWQMIF QRKVKVIVML 
      1060       1070       1080       1090       1100
TELVNGDQEV CAQYWGEGKQ TYGDMEVEMK DTNRASAYTL RTFELRHSKR 
      1110       1120       1130       1140       1150
KEPRTVYQYQ CTTWKGEELP AEPKDLVSMI QDLKQKLPKA SPEGMKYHKH 
      1160       1170       1180       1190       1200
ASILVHCRDG SQQTGLFCAL FNLLESAETE DVVDVFQVVK SLRKARPGVV 
      1210       1220       1230       1240       1250
CSYEQYQFLY DIIASIYPAQ NGQVKKTNSQ DKIEFHNEVD GGKQDANCVR 
      1260       1270       1280       1290 
PDGPLNKAQE DSRGVGTPEP TNSAEEPEHA ANGSASPAPT QSS        

        10         20         30         40         50
MTMGLWLKLL AFGFALLDTE VFVTGQTPTP SDGVLSTLLP HLSPQPDSQT 
        60         70         80         90        100
PSAGGADTQT FSSQADNPTL TPAPGGGTDP PGVPGERTVP GTIPADTAFP 
       110        120        130        140        150
VDTPSLARNS SAASPTHTSN VSTTDISSGA SLTTLTPSTL GLASTDPPST 
       160        170        180        190        200
TIATTTKQTC AAMFGNITVN YTYESSNQTF KADLKDVQNA KCGNEDCENV 
       210        220        230        240        250
LNNLEECSQI KNISVSNDSC APATTIDLYV PPGTDKFSLH DCTPKEKANT 
       260        270        280        290        300
SICLEWKTKN LDFRKCNSDN ISYVLHCEPE NNTKCIRRNT FIPERCQLDN 
       310        320        330        340        350
LRAQTNYTCV AEILYRGVKL VKNVINVQTD LGIPETPKPS CGDPAARKTL 
       360        370        380        390        400
VSWPEPVSKP ESASKPHGYV LCYKNNSEKC KSLPNNVTSF EVESLKPYKY 
       410        420        430        440        450
YEVSLLAYVN GKIQRNGTAE KCNFHTKADR PDKVNGMKTS RPTDNSINVT 
       460        470        480        490        500
CGPPYETNGP KTFYILVVRS GGSFVTKYNK TNCQFYVDNL YYSTDYEFLV 
       510        520        530        540        550
SFHNGVYEGD SVIRNESTNF NAKALIIFLV FLIIVTSIAL LVVLYKIYDL 
       560        570        580        590        600
RKKRSSNLDE QQELVERDDE KQLMDVEPIH SDILLETYKR KIADEGRLFL 
       610        620        630        640        650
AEFQSIPRVF SKFPIKDARK PHNQNKNRYV DILPYDYNRV ELSEINGDAG 
       660        670        680        690        700
STYINASYID GFKEPRKYIA AQGPRDETVD DFWRMIWEQK ATVIVMVTRC 
       710        720        730        740        750
EEGNRNKCAE YWPSMEEGTR AFKDIVVTIN DHKRCPDYII QKLNVAHKKE 
       760        770        780        790        800
KATGREVTHI QFTSWPDHGV PEDPHLLLKL RRRVNAFSNF FSGPIVVHCS 
       810        820        830        840        850
AGVGRTGTYI GIDAMLEGLE AEGKVDVYGY VVKLRRQRCL MVQVEAQYIL 
       860        870        880        890        900
IHQALVEYNQ FGETEVNLSE LHSCLHNMKK RDPPSDPSPL EAEYQRLPSY 
       910        920        930        940        950
RSWRTQHIGN QEENKKKNRN SNVVPYDFNR VPLKHELEMS KESEPESDES 
       960        970        980        990       1000
SDDDSDSEET SKYINASFVM SYWKPEMMIA AQGPLKETIG DFWQMIFQRK 
      1010       1020       1030       1040       1050
VKVIVMLTEL VNGDQEVCAQ YWGEGKQTYG DMEVEMKDTN RASAYTLRTF 
      1060       1070       1080       1090       1100
ELRHSKRKEP RTVYQYQCTT WKGEELPAEP KDLVSMIQDL KQKLPKASPE 
      1110       1120       1130       1140       1150
GMKYHKHASI LVHCRDGSQQ TGLFCALFNL LESAETEDVV DVFQVVKSLR 
      1160       1170       1180       1190       1200
KARPGVVCSY EQYQFLYDII ASIYPAQNGQ VKKTNSQDKI EFHNEVDGGK 
      1210       1220       1230       1240       1250
QDANCVRPDG PLNKAQEDSR GVGTPEPTNS AEEPEHAANG SASPAPTQSS 

        10         20         30         40         50
MTMGLWLKLL AFGFALLDTE VFVTGQTPTP SDGASLTTLT PSTLGLASTD 
        60         70         80         90        100
PPSTTIATTT KQTCAAMFGN ITVNYTYESS NQTFKADLKD VQNAKCGNED 
       110        120        130        140        150
CENVLNNLEE CSQIKNISVS NDSCAPATTI DLYVPPGTDK FSLHDCTPKE 
       160        170        180        190        200
KANTSICLEW KTKNLDFRKC NSDNISYVLH CEPENNTKCI RRNTFIPERC 
       210        220        230        240        250
QLDNLRAQTN YTCVAEILYR GVKLVKNVIN VQTDLGIPET PKPSCGDPAA 
       260        270        280        290        300
RKTLVSWPEP VSKPESASKP HGYVLCYKNN SEKCKSLPNN VTSFEVESLK 
       310        320        330        340        350
PYKYYEVSLL AYVNGKIQRN GTAEKCNFHT KADRPDKVNG MKTSRPTDNS 
       360        370        380        390        400
INVTCGPPYE TNGPKTFYIL VVRSGGSFVT KYNKTNCQFY VDNLYYSTDY 
       410        420        430        440        450
EFLVSFHNGV YEGDSVIRNE STNFNAKALI IFLVFLIIVT SIALLVVLYK 
       460        470        480        490        500
IYDLRKKRSS NLDEQQELVE RDDEKQLMDV EPIHSDILLE TYKRKIADEG 
       510        520        530        540        550
RLFLAEFQSI PRVFSKFPIK DARKPHNQNK NRYVDILPYD YNRVELSEIN 
       560        570        580        590        600
GDAGSTYINA SYIDGFKEPR KYIAAQGPRD ETVDDFWRMI WEQKATVIVM 
       610        620        630        640        650
VTRCEEGNRN KCAEYWPSME EGTRAFKDIV VTINDHKRCP DYIIQKLNVA 
       660        670        680        690        700
HKKEKATGRE VTHIQFTSWP DHGVPEDPHL LLKLRRRVNA FSNFFSGPIV 
       710        720        730        740        750
VHCSAGVGRT GTYIGIDAML EGLEAEGKVD VYGYVVKLRR QRCLMVQVEA 
       760        770        780        790        800
QYILIHQALV EYNQFGETEV NLSELHSCLH NMKKRDPPSD PSPLEAEYQR 
       810        820        830        840        850
LPSYRSWRTQ HIGNQEENKK KNRNSNVVPY DFNRVPLKHE LEMSKESEPE 
       860        870        880        890        900
SDESSDDDSD SEETSKYINA SFVMSYWKPE MMIAAQGPLK ETIGDFWQMI 
       910        920        930        940        950
FQRKVKVIVM LTELVNGDQE VCAQYWGEGK QTYGDMEVEM KDTNRASAYT 
       960        970        980        990       1000
LRTFELRHSK RKEPRTVYQY QCTTWKGEEL PAEPKDLVSM IQDLKQKLPK 
      1010       1020       1030       1040       1050
ASPEGMKYHK HASILVHCRD GSQQTGLFCA LFNLLESAET EDVVDVFQVV 
      1060       1070       1080       1090       1100
KSLRKARPGV VCSYEQYQFL YDIIASIYPA QNGQVKKTNS QDKIEFHNEV 
      1110       1120       1130       1140       1150
DGGKQDANCV RPDGPLNKAQ EDSRGVGTPE PTNSAEEPEH AANGSASPAP 

TQSS                                                   

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families