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UniProtKB - P06800 (PTPRC_MOUSE)

Entry version 212 (07 Oct 2020)
Sequence version 4 (28 Mar 2018)
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Protein

Receptor-type tyrosine-protein phosphatase C

Gene

Ptprc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity.By similarity1 Publication

Caution

It is uncertain whether Met-1 or Met-3 is the initiator.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei810SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei842Phosphocysteine intermediateBy similarity1
Binding sitei886SubstrateBy similarity1
Active sitei1157Phosphocysteine intermediateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-202427, Phosphorylation of CD3 and TCR zeta chains
R-MMU-416700, Other semaphorin interactions
R-MMU-6798695, Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase CCurated (EC:3.1.3.48)
Alternative name(s):
Leukocyte common antigen
Short name:
L-CA
Lymphocyte antigen 5
Short name:
Ly-5
T200
CD_antigen: CD45
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PtprcImported
Synonyms:Ly-5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:97810, Ptprc

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 566ExtracellularSequence analysisAdd BLAST541
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei567 – 588HelicalSequence analysisAdd BLAST22
Topological domaini589 – 1293CytoplasmicSequence analysisAdd BLAST705

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Add BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002547126 – 1293Receptor-type tyrosine-protein phosphatase CAdd BLAST1268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi209N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi255N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi292N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi313N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi324N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi349N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi418N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi429N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi459N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi491N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei672PhosphotyrosineBy similarity1
Modified residuei964PhosphoserineCombined sources1
Modified residuei983PhosphoserineBy similarity1
Modified residuei986PhosphoserineBy similarity1
Modified residuei990PhosphoserineBy similarity1
Modified residuei993PhosphoserineBy similarity1
Modified residuei994PhosphoserineCombined sources1
Modified residuei998PhosphoserineBy similarity1
Modified residuei1229PhosphoserineBy similarity1
Modified residuei1267PhosphothreonineCombined sources1
Modified residuei1286PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Heavily N- and O-glycosylated.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P06800

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P06800

PeptideAtlas

More...PeptideAtlasi		P06800

PRoteomics IDEntifications database

More...PRIDEi		P06800

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2666, 1 N-Linked glycan (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P06800, 16 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P06800

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P06800

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P06800

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expression is restricted to the hematopoietic compartment of development.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000026395, Expressed in spleen and 218 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SKAP1.

Interacts with DPP4; the interaction is enhanced in an interleukin-12-dependent manner in activated lymphocytes (By similarity). Binds GANAB and PRKCSH.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		P06800, 11 interactors

Molecular INTeraction database

More...MINTi		P06800

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000138350

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P06800, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P06800

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini376 – 472Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST97
Domaini473 – 568Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini642 – 901Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST260
Domaini933 – 1216Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST284

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni842 – 848Substrate bindingBy similarity7

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The first PTPase domain interacts with SKAP1.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4228, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159457

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P06800

KEGG Orthology (KO)

More...KOi		K06478

TreeFam database of animal gene trees

More...TreeFami		TF351829

Family and domain databases

Conserved Domains Database

More...CDDi		cd00063, FN3, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 2 hits
3.90.190.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR029021, Prot-tyrosine_phosphatase-like
IPR024739, PTP_recept_N
IPR000242, PTPase_domain
IPR016335, Ptprc
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat
IPR000387, TYR_PHOSPHATASE_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12567, CD45, 1 hit
PF12453, PTP_N, 1 hit
PF00102, Y_phosphatase, 2 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF002004, Leukocyte_common_antigen, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00700, PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00060, FN3, 2 hits
SM00194, PTPc, 2 hits
SM00404, PTPc_motif, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49265, SSF49265, 2 hits
SSF52799, SSF52799, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50853, FN3, 2 hits
PS00383, TYR_PHOSPHATASE_1, 1 hit
PS50056, TYR_PHOSPHATASE_2, 2 hits
PS50055, TYR_PHOSPHATASE_PTP, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P06800-4) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTMGLWLKLL AFGFALLDTE VFVTGQTPTP SDELSTTENA LLLPQSDPLP 
        60         70         80         90        100
ARTTESTPPS ISERGNGSSE TTYHPGVLST LLPHLSPQPD SQTPSAGGAD 
       110        120        130        140        150
TQTFSSQADN PTLTPAPGGG TDPPGVPGER TVPGTIPADT AFPVDTPSLA 
       160        170        180        190        200
RNSSAASPTH TSNVSTTDIS SGASLTTLTP STLGLASTDP PSTTIATTTK 
       210        220        230        240        250
QTCAAMFGNI TVNYTYESSN QTFKADLKDV QNAKCGNEDC ENVLNNLEEC 
       260        270        280        290        300
SQIKNISVSN DSCAPATTID LYVPPGTDKF SLHDCTPKEK ANTSICLEWK 
       310        320        330        340        350
TKNLDFRKCN SDNISYVLHC EPENNTKCIR RNTFIPERCQ LDNLRAQTNY 
       360        370        380        390        400
TCVAEILYRG VKLVKNVINV QTDLGIPETP KPSCGDPAAR KTLVSWPEPV 
       410        420        430        440        450
SKPESASKPH GYVLCYKNNS EKCKSLPNNV TSFEVESLKP YKYYEVSLLA 
       460        470        480        490        500
YVNGKIQRNG TAEKCNFHTK ADRPDKVNGM KTSRPTDNSI NVTCGPPYET 
       510        520        530        540        550
NGPKTFYILV VRSGGSFVTK YNKTNCQFYV DNLYYSTDYE FLVSFHNGVY 
       560        570        580        590        600
EGDSVIRNES TNFNAKALII FLVFLIIVTS IALLVVLYKI YDLRKKRSSN 
       610        620        630        640        650
LDEQQELVER DDEKQLMDVE PIHSDILLET YKRKIADEGR LFLAEFQSIP 
       660        670        680        690        700
RVFSKFPIKD ARKPHNQNKN RYVDILPYDY NRVELSEING DAGSTYINAS 
       710        720        730        740        750
YIDGFKEPRK YIAAQGPRDE TVDDFWRMIW EQKATVIVMV TRCEEGNRNK 
       760        770        780        790        800
CAEYWPSMEE GTRAFKDIVV TINDHKRCPD YIIQKLNVAH KKEKATGREV 
       810        820        830        840        850
THIQFTSWPD HGVPEDPHLL LKLRRRVNAF SNFFSGPIVV HCSAGVGRTG 
       860        870        880        890        900
TYIGIDAMLE GLEAEGKVDV YGYVVKLRRQ RCLMVQVEAQ YILIHQALVE 
       910        920        930        940        950
YNQFGETEVN LSELHSCLHN MKKRDPPSDP SPLEAEYQRL PSYRSWRTQH 
       960        970        980        990       1000
IGNQEENKKK NRNSNVVPYD FNRVPLKHEL EMSKESEPES DESSDDDSDS 
      1010       1020       1030       1040       1050
EETSKYINAS FVMSYWKPEM MIAAQGPLKE TIGDFWQMIF QRKVKVIVML 
      1060       1070       1080       1090       1100
TELVNGDQEV CAQYWGEGKQ TYGDMEVEMK DTNRASAYTL RTFELRHSKR 
      1110       1120       1130       1140       1150
KEPRTVYQYQ CTTWKGEELP AEPKDLVSMI QDLKQKLPKA SPEGMKYHKH 
      1160       1170       1180       1190       1200
ASILVHCRDG SQQTGLFCAL FNLLESAETE DVVDVFQVVK SLRKARPGVV 
      1210       1220       1230       1240       1250
CSYEQYQFLY DIIASIYPAQ NGQVKKTNSQ DKIEFHNEVD GGKQDANCVR 
      1260       1270       1280       1290 
PDGPLNKAQE DSRGVGTPEP TNSAEEPEHA ANGSASPAPT QSS
Length:1,293
Mass (Da):144,837
Last modified:March 28, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i44C3D35121181B31
GO
Isoform 2 (identifier: P06800-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-75: Missing.

Show »
Length:1,250
Mass (Da):140,272
Checksum:iEDC7195D35923C29
GO
Isoform 3 (identifier: P06800-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-171: Missing.

Show »
Length:1,154
Mass (Da):130,855
Checksum:iBDFF3E12E270B07D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R1M0S4R1M0_MOUSE
Protein-tyrosine-phosphatase
Ptprc
1,130Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YXM4A0A0A6YXM4_MOUSE
Receptor-type tyrosine-protein phos...
Ptprc
212Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YWF2A0A0A6YWF2_MOUSE
Receptor-type tyrosine-protein phos...
Ptprc
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA39458 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAA39459 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAA40161 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence AAA40161 differs from that shown. Reason: Frameshift.Curated
The sequence AAA60449 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAB46374 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti302K → E in AAA39459 (PubMed:1822988).Curated1
Sequence conflicti400 – 405VSKPES → ASKPDP in AAA39459 (PubMed:1822988).Curated6
Sequence conflicti478N → T in AAA39459 (PubMed:1822988).Curated1
Sequence conflicti530V → G in AAA39458 (PubMed:2944116).Curated1
Sequence conflicti558N → S in AAA39458 (PubMed:2944116).Curated1
Sequence conflicti590I → S in AAA39458 (PubMed:2944116).Curated1
Sequence conflicti908E → Q in AAA39458 (PubMed:2944116).Curated1
Sequence conflicti933L → R in AAA39458 (PubMed:2944116).Curated1
Sequence conflicti955E → G in AAA39458 (PubMed:2944116).Curated1
Sequence conflicti961N → K in AAA39458 (PubMed:2944116).Curated1
Sequence conflicti966 – 969VVPY → CSID in AAA40161 (PubMed:2948186).Curated4

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05941033 – 171Missing in isoform 3. Add BLAST139
Alternative sequenceiVSP_05941133 – 75Missing in isoform 2. Add BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M14342 mRNA Translation: AAA39458.1 Different initiation.
M92933 mRNA Translation: AAA39459.1 Different initiation.
AC122903 Genomic DNA No translation available.
AC159278 Genomic DNA No translation available.
CH466520 Genomic DNA Translation: EDL39542.1
M17320 mRNA Translation: AAA60449.1 Different initiation.
M23354 Genomic DNA Translation: AAA39462.1
M22456 Genomic DNA Translation: AAB46374.1 Different initiation.
M11934 mRNA Translation: AAA39461.1
M23241 Genomic DNA Translation: AAA39460.1
M15174 mRNA Translation: AAA40161.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS15330.2 [P06800-6]
CCDS48383.2 [P06800-4]

Protein sequence database of the Protein Information Resource

More...PIRi		A23329
A28334
A28335
I57644

NCBI Reference Sequences

More...RefSeqi		NP_001104786.2, NM_001111316.2 [P06800-4]
XP_006529320.1, XM_006529257.1 [P06800-4]
XP_006529321.1, XM_006529258.3 [P06800-4]
XP_006529322.1, XM_006529259.3 [P06800-4]
XP_006529323.1, XM_006529260.1 [P06800-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000182283; ENSMUSP00000138800; ENSMUSG00000026395 [P06800-6]
ENSMUST00000183301; ENSMUSP00000138350; ENSMUSG00000026395 [P06800-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		19264

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:19264

UCSC genome browser

More...UCSCi		uc007cvf.3, mouse [P06800-4]
uc007cvh.3, mouse

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14342 mRNA Translation: AAA39458.1 Different initiation.
M92933 mRNA Translation: AAA39459.1 Different initiation.
AC122903 Genomic DNA No translation available.
AC159278 Genomic DNA No translation available.
CH466520 Genomic DNA Translation: EDL39542.1
M17320 mRNA Translation: AAA60449.1 Different initiation.
M23354 Genomic DNA Translation: AAA39462.1
M22456 Genomic DNA Translation: AAB46374.1 Different initiation.
M11934 mRNA Translation: AAA39461.1
M23241 Genomic DNA Translation: AAA39460.1
M15174 mRNA Translation: AAA40161.1 Sequence problems.
CCDSiCCDS15330.2 [P06800-6]
CCDS48383.2 [P06800-4]
PIRiA23329
A28334
A28335
I57644
RefSeqiNP_001104786.2, NM_001111316.2 [P06800-4]
XP_006529320.1, XM_006529257.1 [P06800-4]
XP_006529321.1, XM_006529258.3 [P06800-4]
XP_006529322.1, XM_006529259.3 [P06800-4]
XP_006529323.1, XM_006529260.1 [P06800-5]

3D structure databases

SMRiP06800
ModBaseiSearch...

Protein-protein interaction databases

IntActiP06800, 11 interactors
MINTiP06800
STRINGi10090.ENSMUSP00000138350

PTM databases

GlyConnecti2666, 1 N-Linked glycan (1 site)
GlyGeniP06800, 16 sites
iPTMnetiP06800
PhosphoSitePlusiP06800
SwissPalmiP06800

Proteomic databases

jPOSTiP06800
PaxDbiP06800
PeptideAtlasiP06800
PRIDEiP06800

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		737, 9128 antibodies

The DNASU plasmid repository

More...DNASUi		19264

Genome annotation databases

EnsembliENSMUST00000182283; ENSMUSP00000138800; ENSMUSG00000026395 [P06800-6]
ENSMUST00000183301; ENSMUSP00000138350; ENSMUSG00000026395 [P06800-4]
GeneIDi19264
KEGGimmu:19264
UCSCiuc007cvf.3, mouse [P06800-4]
uc007cvh.3, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5788
MGIiMGI:97810, Ptprc

Phylogenomic databases

eggNOGiKOG4228, Eukaryota
GeneTreeiENSGT00940000159457
InParanoidiP06800
KOiK06478
TreeFamiTF351829

Enzyme and pathway databases

ReactomeiR-MMU-202427, Phosphorylation of CD3 and TCR zeta chains
R-MMU-416700, Other semaphorin interactions
R-MMU-6798695, Neutrophil degranulation

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		19264, 1 hit in 20 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Ptprc, mouse

Protein Ontology

More...PROi		PR:P06800
RNActiP06800, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000026395, Expressed in spleen and 218 other tissues

Family and domain databases

CDDicd00063, FN3, 2 hits
Gene3Di2.60.40.10, 2 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR029021, Prot-tyrosine_phosphatase-like
IPR024739, PTP_recept_N
IPR000242, PTPase_domain
IPR016335, Ptprc
IPR016130, Tyr_Pase_AS
IPR003595, Tyr_Pase_cat
IPR000387, TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF12567, CD45, 1 hit
PF12453, PTP_N, 1 hit
PF00102, Y_phosphatase, 2 hits
PIRSFiPIRSF002004, Leukocyte_common_antigen, 1 hit
PRINTSiPR00700, PRTYPHPHTASE
SMARTiView protein in SMART
SM00060, FN3, 2 hits
SM00194, PTPc, 2 hits
SM00404, PTPc_motif, 2 hits
SUPFAMiSSF49265, SSF49265, 2 hits
SSF52799, SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853, FN3, 2 hits
PS00383, TYR_PHOSPHATASE_1, 1 hit
PS50056, TYR_PHOSPHATASE_2, 2 hits
PS50055, TYR_PHOSPHATASE_PTP, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPTPRC_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06800
Secondary accession number(s): E9QLT5
, Q61812, Q61813, Q61814, Q61815, Q78EF1, S4R1S4, S4R2V1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: March 28, 2018
Last modified: October 7, 2020
This is version 212 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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