Ptprc

Functionⁱ

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity.By similarity1 Publication

Caution

It is uncertain whether Met-1 or Met-3 is the initiator.Curated

Catalytic activityⁱ

H₂O
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
+
O-phospho-L-tyrosyl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
=
L-tyrosyl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
+
phosphate
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
PROSITE-ProRule annotation
Manual assertion according to rulesⁱ
- PROSITE-ProRule:PRU10044
EC:3.1.3.48
PROSITE-ProRule annotation
Manual assertion according to rulesⁱ
- PROSITE-ProRule:PRU10044
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
H₂O
zoom
+
O-phospho-L-tyrosyl-[protein]
L-tyrosine-phosphate residue
zoom
=
L-tyrosyl-[protein]
L-tyrosine residue
zoom
+
phosphate
zoom

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	810	SubstrateBy similarity	1
Active siteⁱ	842	Phosphocysteine intermediateBy similarity	1
Binding siteⁱ	886	SubstrateBy similarity	1
Active siteⁱ	1157	Phosphocysteine intermediateBy similarity	1

GO - Molecular functionⁱ

ankyrin binding Source: MGI
heparan sulfate proteoglycan binding
Source: MGI
Inferred from direct assayⁱ
- 8043862
heparin binding
Source: MGI
Inferred from direct assayⁱ
- 8043862
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11201744
protein tyrosine phosphatase activity
Source: MGI
Inferred from direct assayⁱ
signaling receptor binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 12115612
spectrin binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of MAPK activity
Source: MGI
Inferred from mutant phenotypeⁱ
- 9254656
B cell differentiation
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- 15557316
- 18249142
B cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8334701
B cell receptor signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8692271
bone marrow development Source: MGI
calcium-mediated signaling using intracellular calcium source
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 18249142
cell cycle phase transition Source: MGI
cellular response to extracellular stimulus
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 15661907
defense response to virus
Source: MGI
Inferred from direct assayⁱ
- 17277142
dephosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 11201744
hematopoietic progenitor cell differentiation Source: MGI
heterotypic cell-cell adhesion
Source: MGI
Inferred from mutant phenotypeⁱ
- 7743522
immunoglobulin biosynthetic process Source: MGI
leukocyte cell-cell adhesion
Source: MGI
Inferred from mutant phenotypeⁱ
- 7743522
natural killer cell differentiation
Source: ARUK-UCL
Inferred from mutant phenotypeⁱ
- 15557316
negative regulation of cell adhesion involved in substrate-bound cell migration Source: MGI
negative regulation of cytokine-mediated signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 11201744
negative regulation of ERK1 and ERK2 cascade
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 15661907
negative regulation of interleukin-2 biosynthetic process
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 15661907
negative regulation of peptidyl-tyrosine phosphorylation
Source: MGI
Inferred from mutant phenotypeⁱ
- 7499277
- 8175795
negative regulation of protein autophosphorylation
Source: MGI
Inferred from mutant phenotypeⁱ
- 7499277
- 8175795
negative regulation of protein kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 10970857
negative regulation of protein tyrosine kinase activity
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 15661907
negative regulation of T cell mediated cytotoxicity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 9725213
negative thymic T cell selection
Source: MGI
Inferred from mutant phenotypeⁱ
- 8666928
plasma membrane raft distribution
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 15661907
positive regulation of alpha-beta T cell proliferation
Source: MGI
Inferred from mutant phenotypeⁱ
- 7751624
positive regulation of antigen receptor-mediated signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8692271
positive regulation of B cell proliferation
Source: MGI
Inferred from mutant phenotypeⁱ
positive regulation of ERK1 and ERK2 cascade
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 15661907
positive regulation of extrinsic apoptotic signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 8666928
positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 18249142
positive regulation of gamma-delta T cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 7807014
positive regulation of hematopoietic stem cell migration Source: MGI
positive regulation of humoral immune response mediated by circulating immunoglobulin
Source: MGI
Inferred from mutant phenotypeⁱ
- 8566034
positive regulation of interleukin-2 biosynthetic process
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 15661907
positive regulation of isotype switching to IgG isotypes
Source: MGI
Inferred from mutant phenotypeⁱ
- 9015183
positive regulation of MAPK cascade
Source: MGI
Inferred from mutant phenotypeⁱ
- 9254656
positive regulation of peptidyl-tyrosine phosphorylation
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 18249142
positive regulation of protein tyrosine phosphatase activity
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 15661907
positive regulation of stem cell proliferation Source: MGI
positive regulation of T cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 8666928
positive regulation of T cell mediated cytotoxicity
Source: MGI
Inferred from mutant phenotypeⁱ
- 6233370
positive regulation of T cell mediated immunity
Source: MGI
Inferred from mutant phenotypeⁱ
- 6233370
- 8566034
positive regulation of T cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8334701
positive regulation of tumor necrosis factor production
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 18249142
positive thymic T cell selection
Source: MGI
Inferred from mutant phenotypeⁱ
- 8666928
protein dephosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 9197241
regulation of B cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 8666928
- 9254656
regulation of B cell receptor signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 7499277
regulation of cell cycle
Source: UniProtKB
Inferred from direct assayⁱ
- 10970857
regulation of extrinsic apoptotic signaling pathway
Source: MGI
Inferred from mutant phenotypeⁱ
- 7743522
regulation of gene expression
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 12496963
regulation of humoral immune response mediated by circulating immunoglobulin
Source: MGI
Inferred from mutant phenotypeⁱ
- 9015183
regulation of interleukin-8 production Source: MGI
regulation of JAK-STAT cascade Source: MGI
regulation of phagocytosis Source: MGI
regulation of protein tyrosine kinase activity Source: MGI
release of sequestered calcium ion into cytosol
Source: UniProtKB
Inferred from direct assayⁱ
- 10508267
response to gamma radiation Source: MGI
stem cell development Source: MGI
T cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8334701
T cell proliferation
Source: MGI
Inferred from mutant phenotypeⁱ
- 12902479
T cell receptor signaling pathway
Source: ARUK-UCL
Inferred from genetic interactionⁱ
- 12496963

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protein phosphatase

Molecular function

Hydrolase, Protein phosphatase

Enzyme and pathway databases

Reactomeⁱ	R-MMU-202427 Phosphorylation of CD3 and TCR zeta chains R-MMU-416700 Other semaphorin interactions R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-202427 Phosphorylation of CD3 and TCR zeta chains
R-MMU-416700 Other semaphorin interactions
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Receptor-type tyrosine-protein phosphatase CCurated (EC:3.1.3.48) Alternative name(s): Leukocyte common antigen Short name: L-CA Lymphocyte antigen 5 Short name: Ly-5 T200 CD_antigen: CD45
Gene namesⁱ	Name:PtprcImported Synonyms:Ly-5
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:97810 Ptprc

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	26 – 566	ExtracellularSequence analysisAdd BLAST	541
Transmembraneⁱ	567 – 588	HelicalSequence analysisAdd BLAST	22
Topological domainⁱ	589 – 1293	CytoplasmicSequence analysisAdd BLAST	705

Keywords - Cellular componentⁱ

Cell membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 25	Add BLAST		25
ChainⁱPRO_0000025471	26 – 1293	Receptor-type tyrosine-protein phosphatase CAdd BLAST		1268

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	66	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	152	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	163	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	209	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	213	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	220	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	255	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	260	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	292	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	313	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	324	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	349	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	418	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	429	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	459	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	491	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	672	PhosphotyrosineBy similarity	1
Modified residueⁱ	964	PhosphoserineCombined sources	1
Modified residueⁱ	983	PhosphoserineBy similarity	1
Modified residueⁱ	986	PhosphoserineBy similarity	1
Modified residueⁱ	990	PhosphoserineBy similarity	1
Modified residueⁱ	993	PhosphoserineBy similarity	1
Modified residueⁱ	994	PhosphoserineCombined sources	1
Modified residueⁱ	998	PhosphoserineBy similarity	1
Modified residueⁱ	1229	PhosphoserineBy similarity	1
Modified residueⁱ	1267	PhosphothreonineCombined sources	1
Modified residueⁱ	1286	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Heavily N- and O-glycosylated.

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

jPOSTⁱ	P06800
PaxDbⁱ	P06800
PeptideAtlas More...PeptideAtlasⁱ	P06800
PRIDEⁱ	P06800

PTM databases

iPTMnetⁱ	P06800
PhosphoSitePlusⁱ	P06800
SwissPalmⁱ	P06800

Expressionⁱ

Developmental stageⁱ

Expression is restricted to the hematopoietic compartment of development.

Gene expression databases

Bgeeⁱ	ENSMUSG00000026395 Expressed in 199 organ(s), highest expression level in spleen
CleanExⁱ	MM_PTPRC

Interactionⁱ

Subunit structureⁱ

Interacts with SKAP1. Interacts with DPP4; the interaction is enhanced in a interleukin-12-dependent manner in activated lymphocytes (By similarity). Binds GANAB and PRKCSH.By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Lck	P06240	2	EBI-1672,EBI-1401

With

Entry

#Exp.

IntAct

Notes

Lck

P06240

2

EBI-1672,EBI-1401

GO - Molecular functionⁱ

ankyrin binding Source: MGI
heparan sulfate proteoglycan binding
Source: MGI
Inferred from direct assayⁱ
- 8043862
protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11201744
signaling receptor binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 12115612
spectrin binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	P06800, 11 interactors
Molecular INTeraction database More...MINTⁱ	P06800
STRINGⁱ	10090.ENSMUSP00000027645

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P06800
SMRⁱ	P06800
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	376 – 472	Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST	97
Domainⁱ	473 – 568	Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST	96
Domainⁱ	642 – 901	Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST	260
Domainⁱ	933 – 1216	Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST	284

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	842 – 848	Substrate bindingBy similarity		7

Domainⁱ

The first PTPase domain interacts with SKAP1.By similarity

Sequence similaritiesⁱ

Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.Curated

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4228 Eukaryota COG5599 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000159457
HOVERGENⁱ	HBG000066
InParanoidⁱ	P06800
KEGG Orthology (KO) More...KOⁱ	K06478
OMAⁱ	QYQYNNW
Database of Orthologous Groups More...OrthoDBⁱ	411281at2759
TreeFamⁱ	TF351829

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00063 FN3, 2 hits
Gene3Dⁱ	2.60.40.10, 2 hits 3.90.190.10, 2 hits
InterProⁱ	View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR013783 Ig-like_fold IPR029021 Prot-tyrosine_phosphatase-like IPR024739 PTP_recept_N IPR000242 PTPase_domain IPR016335 Ptprc IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR000387 TYR_PHOSPHATASE_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12567 CD45, 1 hit PF12453 PTP_N, 1 hit PF00102 Y_phosphatase, 2 hits
PIRSFⁱ	PIRSF002004 Leukocyte_common_antigen, 1 hit
PRINTSⁱ	PR00700 PRTYPHPHTASE
SMARTⁱ	View protein in SMART SM00060 FN3, 2 hits SM00194 PTPc, 2 hits SM00404 PTPc_motif, 2 hits
SUPFAMⁱ	SSF49265 SSF49265, 2 hits SSF52799 SSF52799, 2 hits
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 2 hits PS00383 TYR_PHOSPHATASE_1, 1 hit PS50056 TYR_PHOSPHATASE_2, 2 hits PS50055 TYR_PHOSPHATASE_PTP, 2 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P06800-4) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTMGLWLKLL AFGFALLDTE VFVTGQTPTP SDELSTTENA LLLPQSDPLP 
        60         70         80         90        100
ARTTESTPPS ISERGNGSSE TTYHPGVLST LLPHLSPQPD SQTPSAGGAD 
       110        120        130        140        150
TQTFSSQADN PTLTPAPGGG TDPPGVPGER TVPGTIPADT AFPVDTPSLA 
       160        170        180        190        200
RNSSAASPTH TSNVSTTDIS SGASLTTLTP STLGLASTDP PSTTIATTTK 
       210        220        230        240        250
QTCAAMFGNI TVNYTYESSN QTFKADLKDV QNAKCGNEDC ENVLNNLEEC 
       260        270        280        290        300
SQIKNISVSN DSCAPATTID LYVPPGTDKF SLHDCTPKEK ANTSICLEWK 
       310        320        330        340        350
TKNLDFRKCN SDNISYVLHC EPENNTKCIR RNTFIPERCQ LDNLRAQTNY 
       360        370        380        390        400
TCVAEILYRG VKLVKNVINV QTDLGIPETP KPSCGDPAAR KTLVSWPEPV 
       410        420        430        440        450
SKPESASKPH GYVLCYKNNS EKCKSLPNNV TSFEVESLKP YKYYEVSLLA 
       460        470        480        490        500
YVNGKIQRNG TAEKCNFHTK ADRPDKVNGM KTSRPTDNSI NVTCGPPYET 
       510        520        530        540        550
NGPKTFYILV VRSGGSFVTK YNKTNCQFYV DNLYYSTDYE FLVSFHNGVY 
       560        570        580        590        600
EGDSVIRNES TNFNAKALII FLVFLIIVTS IALLVVLYKI YDLRKKRSSN 
       610        620        630        640        650
LDEQQELVER DDEKQLMDVE PIHSDILLET YKRKIADEGR LFLAEFQSIP 
       660        670        680        690        700
RVFSKFPIKD ARKPHNQNKN RYVDILPYDY NRVELSEING DAGSTYINAS 
       710        720        730        740        750
YIDGFKEPRK YIAAQGPRDE TVDDFWRMIW EQKATVIVMV TRCEEGNRNK 
       760        770        780        790        800
CAEYWPSMEE GTRAFKDIVV TINDHKRCPD YIIQKLNVAH KKEKATGREV 
       810        820        830        840        850
THIQFTSWPD HGVPEDPHLL LKLRRRVNAF SNFFSGPIVV HCSAGVGRTG 
       860        870        880        890        900
TYIGIDAMLE GLEAEGKVDV YGYVVKLRRQ RCLMVQVEAQ YILIHQALVE 
       910        920        930        940        950
YNQFGETEVN LSELHSCLHN MKKRDPPSDP SPLEAEYQRL PSYRSWRTQH 
       960        970        980        990       1000
IGNQEENKKK NRNSNVVPYD FNRVPLKHEL EMSKESEPES DESSDDDSDS 
      1010       1020       1030       1040       1050
EETSKYINAS FVMSYWKPEM MIAAQGPLKE TIGDFWQMIF QRKVKVIVML 
      1060       1070       1080       1090       1100
TELVNGDQEV CAQYWGEGKQ TYGDMEVEMK DTNRASAYTL RTFELRHSKR 
      1110       1120       1130       1140       1150
KEPRTVYQYQ CTTWKGEELP AEPKDLVSMI QDLKQKLPKA SPEGMKYHKH 
      1160       1170       1180       1190       1200
ASILVHCRDG SQQTGLFCAL FNLLESAETE DVVDVFQVVK SLRKARPGVV 
      1210       1220       1230       1240       1250
CSYEQYQFLY DIIASIYPAQ NGQVKKTNSQ DKIEFHNEVD GGKQDANCVR 
      1260       1270       1280       1290 
PDGPLNKAQE DSRGVGTPEP TNSAEEPEHA ANGSASPAPT QSS

Length:1,293

Mass (Da):144,837

Last modified:March 28, 2018 - v4

Checksum:ⁱ44C3D35121181B31

GO

Isoform 2 (identifier: P06800-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
33-75: Missing.

« Hide

        10         20         30         40         50
MTMGLWLKLL AFGFALLDTE VFVTGQTPTP SDGVLSTLLP HLSPQPDSQT 
        60         70         80         90        100
PSAGGADTQT FSSQADNPTL TPAPGGGTDP PGVPGERTVP GTIPADTAFP 
       110        120        130        140        150
VDTPSLARNS SAASPTHTSN VSTTDISSGA SLTTLTPSTL GLASTDPPST 
       160        170        180        190        200
TIATTTKQTC AAMFGNITVN YTYESSNQTF KADLKDVQNA KCGNEDCENV 
       210        220        230        240        250
LNNLEECSQI KNISVSNDSC APATTIDLYV PPGTDKFSLH DCTPKEKANT 
       260        270        280        290        300
SICLEWKTKN LDFRKCNSDN ISYVLHCEPE NNTKCIRRNT FIPERCQLDN 
       310        320        330        340        350
LRAQTNYTCV AEILYRGVKL VKNVINVQTD LGIPETPKPS CGDPAARKTL 
       360        370        380        390        400
VSWPEPVSKP ESASKPHGYV LCYKNNSEKC KSLPNNVTSF EVESLKPYKY 
       410        420        430        440        450
YEVSLLAYVN GKIQRNGTAE KCNFHTKADR PDKVNGMKTS RPTDNSINVT 
       460        470        480        490        500
CGPPYETNGP KTFYILVVRS GGSFVTKYNK TNCQFYVDNL YYSTDYEFLV 
       510        520        530        540        550
SFHNGVYEGD SVIRNESTNF NAKALIIFLV FLIIVTSIAL LVVLYKIYDL 
       560        570        580        590        600
RKKRSSNLDE QQELVERDDE KQLMDVEPIH SDILLETYKR KIADEGRLFL 
       610        620        630        640        650
AEFQSIPRVF SKFPIKDARK PHNQNKNRYV DILPYDYNRV ELSEINGDAG 
       660        670        680        690        700
STYINASYID GFKEPRKYIA AQGPRDETVD DFWRMIWEQK ATVIVMVTRC 
       710        720        730        740        750
EEGNRNKCAE YWPSMEEGTR AFKDIVVTIN DHKRCPDYII QKLNVAHKKE 
       760        770        780        790        800
KATGREVTHI QFTSWPDHGV PEDPHLLLKL RRRVNAFSNF FSGPIVVHCS 
       810        820        830        840        850
AGVGRTGTYI GIDAMLEGLE AEGKVDVYGY VVKLRRQRCL MVQVEAQYIL 
       860        870        880        890        900
IHQALVEYNQ FGETEVNLSE LHSCLHNMKK RDPPSDPSPL EAEYQRLPSY 
       910        920        930        940        950
RSWRTQHIGN QEENKKKNRN SNVVPYDFNR VPLKHELEMS KESEPESDES 
       960        970        980        990       1000
SDDDSDSEET SKYINASFVM SYWKPEMMIA AQGPLKETIG DFWQMIFQRK 
      1010       1020       1030       1040       1050
VKVIVMLTEL VNGDQEVCAQ YWGEGKQTYG DMEVEMKDTN RASAYTLRTF 
      1060       1070       1080       1090       1100
ELRHSKRKEP RTVYQYQCTT WKGEELPAEP KDLVSMIQDL KQKLPKASPE 
      1110       1120       1130       1140       1150
GMKYHKHASI LVHCRDGSQQ TGLFCALFNL LESAETEDVV DVFQVVKSLR 
      1160       1170       1180       1190       1200
KARPGVVCSY EQYQFLYDII ASIYPAQNGQ VKKTNSQDKI EFHNEVDGGK 
      1210       1220       1230       1240       1250
QDANCVRPDG PLNKAQEDSR GVGTPEPTNS AEEPEHAANG SASPAPTQSS

Show »

Length:1,250

Mass (Da):140,272

Checksum:ⁱEDC7195D35923C29

GO

Isoform 3 (identifier: P06800-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
33-171: Missing.

« Hide

        10         20         30         40         50
MTMGLWLKLL AFGFALLDTE VFVTGQTPTP SDGASLTTLT PSTLGLASTD 
        60         70         80         90        100
PPSTTIATTT KQTCAAMFGN ITVNYTYESS NQTFKADLKD VQNAKCGNED 
       110        120        130        140        150
CENVLNNLEE CSQIKNISVS NDSCAPATTI DLYVPPGTDK FSLHDCTPKE 
       160        170        180        190        200
KANTSICLEW KTKNLDFRKC NSDNISYVLH CEPENNTKCI RRNTFIPERC 
       210        220        230        240        250
QLDNLRAQTN YTCVAEILYR GVKLVKNVIN VQTDLGIPET PKPSCGDPAA 
       260        270        280        290        300
RKTLVSWPEP VSKPESASKP HGYVLCYKNN SEKCKSLPNN VTSFEVESLK 
       310        320        330        340        350
PYKYYEVSLL AYVNGKIQRN GTAEKCNFHT KADRPDKVNG MKTSRPTDNS 
       360        370        380        390        400
INVTCGPPYE TNGPKTFYIL VVRSGGSFVT KYNKTNCQFY VDNLYYSTDY 
       410        420        430        440        450
EFLVSFHNGV YEGDSVIRNE STNFNAKALI IFLVFLIIVT SIALLVVLYK 
       460        470        480        490        500
IYDLRKKRSS NLDEQQELVE RDDEKQLMDV EPIHSDILLE TYKRKIADEG 
       510        520        530        540        550
RLFLAEFQSI PRVFSKFPIK DARKPHNQNK NRYVDILPYD YNRVELSEIN 
       560        570        580        590        600
GDAGSTYINA SYIDGFKEPR KYIAAQGPRD ETVDDFWRMI WEQKATVIVM 
       610        620        630        640        650
VTRCEEGNRN KCAEYWPSME EGTRAFKDIV VTINDHKRCP DYIIQKLNVA 
       660        670        680        690        700
HKKEKATGRE VTHIQFTSWP DHGVPEDPHL LLKLRRRVNA FSNFFSGPIV 
       710        720        730        740        750
VHCSAGVGRT GTYIGIDAML EGLEAEGKVD VYGYVVKLRR QRCLMVQVEA 
       760        770        780        790        800
QYILIHQALV EYNQFGETEV NLSELHSCLH NMKKRDPPSD PSPLEAEYQR 
       810        820        830        840        850
LPSYRSWRTQ HIGNQEENKK KNRNSNVVPY DFNRVPLKHE LEMSKESEPE 
       860        870        880        890        900
SDESSDDDSD SEETSKYINA SFVMSYWKPE MMIAAQGPLK ETIGDFWQMI 
       910        920        930        940        950
FQRKVKVIVM LTELVNGDQE VCAQYWGEGK QTYGDMEVEM KDTNRASAYT 
       960        970        980        990       1000
LRTFELRHSK RKEPRTVYQY QCTTWKGEEL PAEPKDLVSM IQDLKQKLPK 
      1010       1020       1030       1040       1050
ASPEGMKYHK HASILVHCRD GSQQTGLFCA LFNLLESAET EDVVDVFQVV 
      1060       1070       1080       1090       1100
KSLRKARPGV VCSYEQYQFL YDIIASIYPA QNGQVKKTNS QDKIEFHNEV 
      1110       1120       1130       1140       1150
DGGKQDANCV RPDGPLNKAQ EDSRGVGTPE PTNSAEEPEH AANGSASPAP 

TQSS

Show »

Length:1,154

Mass (Da):130,855

Checksum:ⁱBDFF3E12E270B07D

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

S4R1M0	S4R1M0_MOUSE	Receptor-type tyrosine-protein phos... Receptor-type tyrosine-protein phosphatase C	Ptprc	1,130	Annotation score:
A0A0A6YXM4	A0A0A6YXM4_MOUSE	Receptor-type tyrosine-protein phos... Receptor-type tyrosine-protein phosphatase C	Ptprc	212	Annotation score:
A0A0A6YWF2	A0A0A6YWF2_MOUSE	Receptor-type tyrosine-protein phos... Receptor-type tyrosine-protein phosphatase C	Ptprc	94	Annotation score:

Sequence cautionⁱ

The sequence AAA39458 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAA39459 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAA40161 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

The sequence AAA40161 differs from that shown. Reason: Frameshift at position 969.Curated

The sequence AAA60449 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAB46374 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	302	K → E in AAA39459 (PubMed:1822988).Curated	1
Sequence conflictⁱ	400 – 405	VSKPES → ASKPDP in AAA39459 (PubMed:1822988).Curated	6
Sequence conflictⁱ	478	N → T in AAA39459 (PubMed:1822988).Curated	1
Sequence conflictⁱ	530	V → G in AAA39458 (PubMed:2944116).Curated	1
Sequence conflictⁱ	558	N → S in AAA39458 (PubMed:2944116).Curated	1
Sequence conflictⁱ	590	I → S in AAA39458 (PubMed:2944116).Curated	1
Sequence conflictⁱ	908	E → Q in AAA39458 (PubMed:2944116).Curated	1
Sequence conflictⁱ	933	L → R in AAA39458 (PubMed:2944116).Curated	1
Sequence conflictⁱ	955	E → G in AAA39458 (PubMed:2944116).Curated	1
Sequence conflictⁱ	961	N → K in AAA39458 (PubMed:2944116).Curated	1
Sequence conflictⁱ	966 – 969	VVPY → CSID in AAA40161 (PubMed:2948186).Curated	4

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_059410	33 – 171	Missing in isoform 3. Add BLAST		139
Alternative sequenceⁱVSP_059411	33 – 75	Missing in isoform 2. Add BLAST		43

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M14342 mRNA Translation: AAA39458.1 Different initiation. M92933 mRNA Translation: AAA39459.1 Different initiation. AC122903 Genomic DNA No translation available. AC159278 Genomic DNA No translation available. CH466520 Genomic DNA Translation: EDL39542.1 M17320 mRNA Translation: AAA60449.1 Different initiation. M23354 Genomic DNA Translation: AAA39462.1 M22456 Genomic DNA Translation: AAB46374.1 Different initiation. M11934 mRNA Translation: AAA39461.1 M23241 Genomic DNA Translation: AAA39460.1 M15174 mRNA Translation: AAA40161.1 Sequence problems.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15330.2 [P06800-6] CCDS48383.2 [P06800-4]
PIRⁱ	A23329 A28334 A28335 I57644
NCBI Reference Sequences More...RefSeqⁱ	NP_001104786.2, NM_001111316.2 [P06800-4] NP_035340.3, NM_011210.4 [P06800-6] XP_006529320.1, XM_006529257.1 [P06800-4] XP_006529321.1, XM_006529258.3 [P06800-4] XP_006529322.1, XM_006529259.3 [P06800-4] XP_006529323.1, XM_006529260.1 [P06800-5]
UniGeneⁱ	Mm.391573

Genome annotation databases

Ensemblⁱ	ENSMUST00000182283; ENSMUSP00000138800; ENSMUSG00000026395 [P06800-6] ENSMUST00000183301; ENSMUSP00000138350; ENSMUSG00000026395 [P06800-4]
GeneIDⁱ	19264
KEGGⁱ	mmu:19264
UCSC genome browser More...UCSCⁱ	uc007cvf.3 mouse [P06800-4] uc007cvh.3 mouse

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P06800	Lymphocyte common antigen (Fragment)		MOUSE		140	UniRef100_P06800
Putative Receptor-type tyrosine-protein phosphatase C		Daphnia magna		814
P06800-6	Uncharacterized protein (Fragment)		MOUSE		879	UniRef100_P06800-6

Protein	Similar proteins		Species	Score	Length	Source
P06800	Lymphocyte common antigen (Fragment)		MOUSE		140	UniRef90_P06800
Putative Receptor-type tyrosine-protein phosphatase C		Daphnia magna		814
UPI000A31B413		MUSCR		1286
Isoform 2 of Receptor-type tyrosine-protein phosphatase C		MOUSE		1250
Isoform 3 of Receptor-type tyrosine-protein phosphatase C		MOUSE		1154
+6

Protein	Similar proteins		Species	Score	Length	Source
P06800	Receptor-type tyrosine-protein phosphatase C	)	HUMAN		1306	UniRef50_P08575
CD45 (Fragment)		PANTR		47
CD45 (Fragment)		western gorilla		47
CD45 (Fragment)		HYLME		24
CD45 (Fragment)		PONPY		46
+598

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M14342 mRNA Translation: AAA39458.1 Different initiation. M92933 mRNA Translation: AAA39459.1 Different initiation. AC122903 Genomic DNA No translation available. AC159278 Genomic DNA No translation available. CH466520 Genomic DNA Translation: EDL39542.1 M17320 mRNA Translation: AAA60449.1 Different initiation. M23354 Genomic DNA Translation: AAA39462.1 M22456 Genomic DNA Translation: AAB46374.1 Different initiation. M11934 mRNA Translation: AAA39461.1 M23241 Genomic DNA Translation: AAA39460.1 M15174 mRNA Translation: AAA40161.1 Sequence problems.
CCDSⁱ	CCDS15330.2 [P06800-6] CCDS48383.2 [P06800-4]
PIRⁱ	A23329 A28334 A28335 I57644
RefSeqⁱ	NP_001104786.2, NM_001111316.2 [P06800-4] NP_035340.3, NM_011210.4 [P06800-6] XP_006529320.1, XM_006529257.1 [P06800-4] XP_006529321.1, XM_006529258.3 [P06800-4] XP_006529322.1, XM_006529259.3 [P06800-4] XP_006529323.1, XM_006529260.1 [P06800-5]
UniGeneⁱ	Mm.391573

3D structure databases

ProteinModelPortalⁱ	P06800
SMRⁱ	P06800
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P06800, 11 interactors
MINTⁱ	P06800
STRINGⁱ	10090.ENSMUSP00000027645

PTM databases

iPTMnetⁱ	P06800
PhosphoSitePlusⁱ	P06800
SwissPalmⁱ	P06800

Proteomic databases

jPOSTⁱ	P06800
PaxDbⁱ	P06800
PeptideAtlasⁱ	P06800
PRIDEⁱ	P06800

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	19264
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000182283; ENSMUSP00000138800; ENSMUSG00000026395 [P06800-6] ENSMUST00000183301; ENSMUSP00000138350; ENSMUSG00000026395 [P06800-4]
GeneIDⁱ	19264
KEGGⁱ	mmu:19264
UCSCⁱ	uc007cvf.3 mouse [P06800-4] uc007cvh.3 mouse

Organism-specific databases

CTDⁱ	5788
MGIⁱ	MGI:97810 Ptprc

Phylogenomic databases

eggNOGⁱ	KOG4228 Eukaryota COG5599 LUCA
GeneTreeⁱ	ENSGT00940000159457
HOVERGENⁱ	HBG000066
InParanoidⁱ	P06800
KOⁱ	K06478
OMAⁱ	QYQYNNW
OrthoDBⁱ	411281at2759
TreeFamⁱ	TF351829

Enzyme and pathway databases

Reactomeⁱ	R-MMU-202427 Phosphorylation of CD3 and TCR zeta chains R-MMU-416700 Other semaphorin interactions R-MMU-6798695 Neutrophil degranulation

Reactomeⁱ

R-MMU-202427 Phosphorylation of CD3 and TCR zeta chains
R-MMU-416700 Other semaphorin interactions
R-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P06800
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000026395 Expressed in 199 organ(s), highest expression level in spleen
CleanExⁱ	MM_PTPRC

Family and domain databases

CDDⁱ	cd00063 FN3, 2 hits
Gene3Dⁱ	2.60.40.10, 2 hits 3.90.190.10, 2 hits
InterProⁱ	View protein in InterPro IPR003961 FN3_dom IPR036116 FN3_sf IPR013783 Ig-like_fold IPR029021 Prot-tyrosine_phosphatase-like IPR024739 PTP_recept_N IPR000242 PTPase_domain IPR016335 Ptprc IPR016130 Tyr_Pase_AS IPR003595 Tyr_Pase_cat IPR000387 TYR_PHOSPHATASE_dom
Pfamⁱ	View protein in Pfam PF12567 CD45, 1 hit PF12453 PTP_N, 1 hit PF00102 Y_phosphatase, 2 hits
PIRSFⁱ	PIRSF002004 Leukocyte_common_antigen, 1 hit
PRINTSⁱ	PR00700 PRTYPHPHTASE
SMARTⁱ	View protein in SMART SM00060 FN3, 2 hits SM00194 PTPc, 2 hits SM00404 PTPc_motif, 2 hits
SUPFAMⁱ	SSF49265 SSF49265, 2 hits SSF52799 SSF52799, 2 hits
PROSITEⁱ	View protein in PROSITE PS50853 FN3, 2 hits PS00383 TYR_PHOSPHATASE_1, 1 hit PS50056 TYR_PHOSPHATASE_2, 2 hits PS50055 TYR_PHOSPHATASE_PTP, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PTPRC_MOUSE
Accessionⁱ	P06800Primary (citable) accession number: P06800 Secondary accession number(s): E9QLT5 S4R2V1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
	Last sequence update:	March 28, 2018
	Last modified:	January 16, 2019
	This is version 198 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

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Supporting data

UniProtKB - P06800 (PTPRC_MOUSE)

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Receptor-type tyrosine-protein phosphatase C

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Catalytic activityⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ