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Protein

Homeobox protein Hox-A4

Gene

Hoxa4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT-3'.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi180 – 239HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

  • activating transcription factor binding Source: GO_Central
  • DNA binding Source: MGI
  • DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • embryonic skeletal system morphogenesis Source: MGI
  • multicellular organism development Source: MGI
  • skeletal system development Source: GO_Central

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-A4
Alternative name(s):
Homeobox protein Hox-1.4
Homeobox protein MH-3
Gene namesi
Name:Hoxa4
Synonyms:Hox-1.4, Hoxa-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96176 Hoxa4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Overexpression results in abnormal gut development (megacolon).

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002000491 – 285Homeobox protein Hox-A4Add BLAST285

Proteomic databases

MaxQBiP06798
PaxDbiP06798
PeptideAtlasiP06798
PRIDEiP06798

PTM databases

iPTMnetiP06798
PhosphoSitePlusiP06798

Expressioni

Developmental stagei

During development of the prepuberal testis high levels of HOXA4 transcripts were found at days 17, 24 and 30. The first day of HOXA4 expression was day 14. The activation of the HOXA4 gene in male germ cells seems to occur at the pachytene stage of meiotic prophase and its level of expression is stage-specific during embryogenesis.

Gene expression databases

CleanExiMM_HOXA4

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200369, 1 interactor
STRINGi10090.ENSMUSP00000098943

Structurei

3D structure databases

ProteinModelPortaliP06798
SMRiP06798
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi159 – 164Antp-type hexapeptide6

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
HOGENOMiHOG000231179
HOVERGENiHBG016849
InParanoidiP06798
KOiK09304
PhylomeDBiP06798
TreeFamiTF352857

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P06798-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTMSSFLINS NYIEPKFPPF EEFAPHGGPG GGDGAVGGGP GYPRPQSAPH
60 70 80 90 100
LPAPNPHAAR QPPAYYAPRA REPSYPGGLY PAPAAACPYA CRGASPGRPE
110 120 130 140 150
QSPAPGAHPS PAPQPPVPLG HCAPGPTTPA VATGGSAPAC PLLLADQGPA
160 170 180 190 200
GPKGKEPVVY PWMKKIHVSA VNSSYNGGEP KRSRTAYTRQ QVLELEKEFH
210 220 230 240 250
FNRYLTRRRR IEIAHTLCLS ERQVKIWFQN RRMKWKKDHK LPNTKMRSSN
260 270 280
TASAPAGPPG KAQTHSPHHH PHPLPGASTP IPSSI
Length:285
Mass (Da):30,468
Last modified:July 15, 1999 - v4
Checksum:i475D48D6C6302A26
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J193A0A0R4J193_MOUSE
Homeobox A4
Hoxa4 mCG_1050160
285Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97G → A in BAC36181 (PubMed:16141072).Curated1
Sequence conflicti97G → A in CAA47330 (PubMed:2576648).Curated1
Sequence conflicti117 – 120VPLG → APPR in BAC36181 (PubMed:16141072).Curated4
Sequence conflicti181K → E in CAA35228 (PubMed:1686835).Curated1
Sequence conflicti181K → E in AAA37831 (PubMed:3726554).Curated1
Sequence conflicti210Missing in AAA37831 (PubMed:3726554).Curated1
Sequence conflicti269H → P (PubMed:7909702).Curated1
Sequence conflicti269H → P (PubMed:7901228).Curated1
Sequence conflicti269H → P in BAC36181 (PubMed:16141072).Curated1
Sequence conflicti272 – 273HP → PE (PubMed:3726554).Curated2
Sequence conflicti279 – 285TPIPSSI → HPFPPPYNLETWISFSHLCA LLISAPVLICSSLSKPETPK QNPTCWKP in CAA31889 (PubMed:1686835).Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S70444 Genomic DNA Translation: AAB30705.2
S67058 Genomic DNA Translation: AAB28662.2
AK076098 mRNA Translation: BAC36181.1
X66861 Genomic DNA Translation: CAA47330.1
X13538 mRNA Translation: CAA31889.1
X17346 Genomic DNA Translation: CAA35228.1
M27432 mRNA Translation: AAA16440.1
M13813 mRNA Translation: AAA37831.1
CCDSiCCDS20142.1
PIRiA43556
RefSeqiNP_032291.1, NM_008265.3
UniGeneiMm.439647

Genome annotation databases

GeneIDi15401
KEGGimmu:15401
UCSCiuc009byf.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S70444 Genomic DNA Translation: AAB30705.2
S67058 Genomic DNA Translation: AAB28662.2
AK076098 mRNA Translation: BAC36181.1
X66861 Genomic DNA Translation: CAA47330.1
X13538 mRNA Translation: CAA31889.1
X17346 Genomic DNA Translation: CAA35228.1
M27432 mRNA Translation: AAA16440.1
M13813 mRNA Translation: AAA37831.1
CCDSiCCDS20142.1
PIRiA43556
RefSeqiNP_032291.1, NM_008265.3
UniGeneiMm.439647

3D structure databases

ProteinModelPortaliP06798
SMRiP06798
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200369, 1 interactor
STRINGi10090.ENSMUSP00000098943

PTM databases

iPTMnetiP06798
PhosphoSitePlusiP06798

Proteomic databases

MaxQBiP06798
PaxDbiP06798
PeptideAtlasiP06798
PRIDEiP06798

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi15401
KEGGimmu:15401
UCSCiuc009byf.1 mouse

Organism-specific databases

CTDi3201
MGIiMGI:96176 Hoxa4

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
HOGENOMiHOG000231179
HOVERGENiHBG016849
InParanoidiP06798
KOiK09304
PhylomeDBiP06798
TreeFamiTF352857

Miscellaneous databases

PROiPR:P06798
SOURCEiSearch...

Gene expression databases

CleanExiMM_HOXA4

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017995 Homeobox_antennapedia
IPR001827 Homeobox_Antennapedia_CS
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00025 ANTENNAPEDIA
PR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00032 ANTENNAPEDIA, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHXA4_MOUSE
AccessioniPrimary (citable) accession number: P06798
Secondary accession number(s): Q61684, Q64388, Q8BPE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: July 15, 1999
Last modified: November 7, 2018
This is version 174 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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