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Protein

Kappa-casein

Gene

Csn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.

GO - Biological processi

  • lactation Source: MGI
  • protein stabilization Source: MGI

Keywordsi

Molecular functionMilk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-casein
Gene namesi
Name:Csn3
Synonyms:Csn10, Csnk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:107461 Csn3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000000449922 – 181Kappa-caseinAdd BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei123PhosphothreonineSequence analysis1
Glycosylationi134O-linked (GalNAc...) threonineBy similarity1
Glycosylationi144O-linked (GalNAc...) threonineBy similarity1
Glycosylationi155O-linked (GalNAc...) threonineBy similarity1
Modified residuei162Phosphoserine; alternateBy similarity1
Glycosylationi162O-linked (GalNAc...) serine; alternateBy similarity1
Modified residuei178PhosphoserineBy similarity1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei118 – 119Cleavage; by chymosin/rennin2

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP06796
PeptideAtlasiP06796
PRIDEiP06796

PTM databases

PhosphoSitePlusiP06796

Miscellaneous databases

PMAP-CutDBiP06796

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

BgeeiENSMUSG00000001622 Expressed in 68 organ(s), highest expression level in inguinal mammary gland
CleanExiMM_CSN3
GenevisibleiP06796 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001667

Structurei

3D structure databases

ProteinModelPortaliP06796
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the kappa-casein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCVG Eukaryota
ENOG4111E7Q LUCA
GeneTreeiENSGT00390000009184
HOGENOMiHOG000111309
HOVERGENiHBG005246
InParanoidiP06796
KOiK17282
OMAiRPHAQIP
OrthoDBiEOG091G105X
TreeFamiTF338369

Family and domain databases

InterProiView protein in InterPro
IPR000117 Casein_kappa
PANTHERiPTHR11470 PTHR11470, 1 hit
PfamiView protein in Pfam
PF00997 Casein_kappa, 1 hit
PIRSFiPIRSF002374 Casein_kappa, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06796-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMRNFIVVVN ILALTLPFLA AEIQNPDSNC RGEKNDIVYD EQRVLYTPVR
60 70 80 90 100
SVLNFNQYEP NYYHYRPSLP ATASPYMYYP LVVRLLLLRS PAPISKWQSM
110 120 130 140 150
PNFPQSAGVP YAIPNPSFLA MPTNENQDNT AIPTIDPITP IVSTPVPTME
160 170 180
SIVNTVANPE ASTVSINTPE TTTVPVSSTA A
Length:181
Mass (Da):20,030
Last modified:October 3, 2012 - v2
Checksum:i0EBEBF116A147F66
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9V → M in AAA37370 (PubMed:4042811).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10114 mRNA Translation: AAA37370.1
AK021350 mRNA Translation: BAB32382.1
AK085710 mRNA Translation: BAC39516.1
AK142607 mRNA Translation: BAE25129.1
AK142673 mRNA Translation: BAE25155.1
AK164788 mRNA Translation: BAE37916.1
AC022298 Genomic DNA No translation available.
BC049949 mRNA Translation: AAH49949.1
BC050269 mRNA Translation: AAH50269.1
CCDSiCCDS19396.1
PIRiA05080
RefSeqiNP_031812.2, NM_007786.4
XP_006534828.1, XM_006534765.2
UniGeneiMm.296303

Genome annotation databases

EnsembliENSMUST00000001667; ENSMUSP00000001667; ENSMUSG00000001622
ENSMUST00000113267; ENSMUSP00000108892; ENSMUSG00000001622
ENSMUST00000113271; ENSMUSP00000108896; ENSMUSG00000001622
GeneIDi12994
KEGGimmu:12994
UCSCiuc008xzg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10114 mRNA Translation: AAA37370.1
AK021350 mRNA Translation: BAB32382.1
AK085710 mRNA Translation: BAC39516.1
AK142607 mRNA Translation: BAE25129.1
AK142673 mRNA Translation: BAE25155.1
AK164788 mRNA Translation: BAE37916.1
AC022298 Genomic DNA No translation available.
BC049949 mRNA Translation: AAH49949.1
BC050269 mRNA Translation: AAH50269.1
CCDSiCCDS19396.1
PIRiA05080
RefSeqiNP_031812.2, NM_007786.4
XP_006534828.1, XM_006534765.2
UniGeneiMm.296303

3D structure databases

ProteinModelPortaliP06796
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001667

PTM databases

PhosphoSitePlusiP06796

Proteomic databases

PaxDbiP06796
PeptideAtlasiP06796
PRIDEiP06796

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001667; ENSMUSP00000001667; ENSMUSG00000001622
ENSMUST00000113267; ENSMUSP00000108892; ENSMUSG00000001622
ENSMUST00000113271; ENSMUSP00000108896; ENSMUSG00000001622
GeneIDi12994
KEGGimmu:12994
UCSCiuc008xzg.1 mouse

Organism-specific databases

CTDi1448
MGIiMGI:107461 Csn3

Phylogenomic databases

eggNOGiENOG410JCVG Eukaryota
ENOG4111E7Q LUCA
GeneTreeiENSGT00390000009184
HOGENOMiHOG000111309
HOVERGENiHBG005246
InParanoidiP06796
KOiK17282
OMAiRPHAQIP
OrthoDBiEOG091G105X
TreeFamiTF338369

Miscellaneous databases

ChiTaRSiCsn3 mouse
PMAP-CutDBiP06796
PROiPR:P06796
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000001622 Expressed in 68 organ(s), highest expression level in inguinal mammary gland
CleanExiMM_CSN3
GenevisibleiP06796 MM

Family and domain databases

InterProiView protein in InterPro
IPR000117 Casein_kappa
PANTHERiPTHR11470 PTHR11470, 1 hit
PfamiView protein in Pfam
PF00997 Casein_kappa, 1 hit
PIRSFiPIRSF002374 Casein_kappa, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCASK_MOUSE
AccessioniPrimary (citable) accession number: P06796
Secondary accession number(s): Q9D1U2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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