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Protein

Multidrug resistance protein 1B

Gene

Abcb1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.

Miscellaneous

In mouse the MDR gene family includes three or more related but distinct cellular genes.

Catalytic activityi

ATP + H2O + xenobiotic(Side 1) = ADP + phosphate + xenobiotic(Side 2).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi426 – 433ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1068 – 1075ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTranslocase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-382556 ABC-family proteins mediated transport
SABIO-RKiP06795

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance protein 1B (EC:7.6.2.2)
Alternative name(s):
ATP-binding cassette sub-family B member 1B
P-glycoprotein 1
CD_antigen: CD243
Gene namesi
Name:Abcb1b
Synonyms:Abcb1, Mdr1, Mdr1b, Pgy1, Pgy1-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:97568 Abcb1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43CytoplasmicBy similarityAdd BLAST43
Transmembranei44 – 66HelicalPROSITE-ProRule annotationAdd BLAST23
Topological domaini67 – 115ExtracellularBy similarityAdd BLAST49
Transmembranei116 – 136HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini137 – 185CytoplasmicBy similarityAdd BLAST49
Transmembranei186 – 207HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini208 – 214ExtracellularBy similarity7
Transmembranei215 – 235HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini236 – 293CytoplasmicBy similarityAdd BLAST58
Transmembranei294 – 315HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini316 – 329ExtracellularBy similarityAdd BLAST14
Transmembranei330 – 351HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini352 – 709CytoplasmicBy similarityAdd BLAST358
Transmembranei710 – 730HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini731 – 754ExtracellularBy similarityAdd BLAST24
Transmembranei755 – 775HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini776 – 830CytoplasmicBy similarityAdd BLAST55
Transmembranei831 – 851HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini852ExtracellularBy similarity1
Transmembranei853 – 872HelicalPROSITE-ProRule annotationAdd BLAST20
Topological domaini873 – 932CytoplasmicBy similarityAdd BLAST60
Transmembranei933 – 955HelicalPROSITE-ProRule annotationAdd BLAST23
Topological domaini956 – 971ExtracellularBy similarityAdd BLAST16
Transmembranei972 – 993HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini994 – 1276CytoplasmicBy similarityAdd BLAST283

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3467

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000933341 – 1276Multidrug resistance protein 1BAdd BLAST1276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei641PhosphotyrosineCombined sources1
Modified residuei659PhosphoserineCombined sources1

Post-translational modificationi

Several phosphorylated serine residues are present in the linker domain.

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP06795
MaxQBiP06795
PaxDbiP06795
PRIDEiP06795

PTM databases

iPTMnetiP06795
PhosphoSitePlusiP06795
SwissPalmiP06795

Expressioni

Gene expression databases

BgeeiENSMUSG00000028970 Expressed in 176 organ(s), highest expression level in adrenal gland
ExpressionAtlasiP06795 baseline and differential
GenevisibleiP06795 MM

Interactioni

Subunit structurei

Interacts with PSMB5.By similarity

Protein-protein interaction databases

IntActiP06795, 1 interactor
MINTiP06795
STRINGi10090.ENSMUSP00000009058

Chemistry databases

BindingDBiP06795

Structurei

3D structure databases

ProteinModelPortaliP06795
SMRiP06795
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini50 – 356ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST307
Domaini391 – 627ABC transporter 1PROSITE-ProRule annotationAdd BLAST237
Domaini709 – 998ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST290
Domaini1033 – 1271ABC transporter 2PROSITE-ProRule annotationAdd BLAST239

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0055 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00530000062896
HOVERGENiHBG080809
InParanoidiP06795
KOiK05658
OMAiFIMYWKT
OrthoDBiEOG091G0HVA
PhylomeDBiP06795
TreeFamiTF105193

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
IPR039421 Type_I_exporter
PANTHERiPTHR24221 PTHR24221, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P06795-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFEENLKGR ADKNFSKMGK KSKKEKKEKK PAVGVFGMFR YADWLDKLCM
60 70 80 90 100
ILGTLAAIIH GTLLPLLMLV FGNMTDSFTK AEASILPSIT NQSGPNSTLI
110 120 130 140 150
ISNSSLEEEM AIYAYYYTGI GAGVLIVAYI QVSLWCLAAG RQIHKIRQKF
160 170 180 190 200
FHAIMNQEIG WFDVHDVGEL NTRLTDDVSK INDGIGDKIG MFFQSITTFL
210 220 230 240 250
AGFIIGFISG WKLTLVILAV SPLIGLSSAL WAKVLTSFTN KELQAYAKAG
260 270 280 290 300
AVAEEVLAAI RTVIAFGGQQ KELERYNKNL EEAKNVGIKK AITASISIGI
310 320 330 340 350
AYLLVYASYA LAFWYGTSLV LSNEYSIGEV LTVFFSILLG TFSIGHLAPN
360 370 380 390 400
IEAFANARGA AFEIFKIIDN EPSIDSFSTK GYKPDSIMGN LEFKNVHFNY
410 420 430 440 450
PSRSEVQILK GLNLKVKSGQ TVALVGNSGC GKSTTVQLMQ RLYDPLEGVV
460 470 480 490 500
SIDGQDIRTI NVRYLREIIG VVSQEPVLFA TTIAENIRYG REDVTMDEIE
510 520 530 540 550
KAVKEANAYD FIMKLPHQFD TLVGERGAQL SGGQKQRIAI ARALVRNPKI
560 570 580 590 600
LLLDEATSAL DTESEAVVQA ALDKAREGRT TIVIAHRLST VRNADVIAGF
610 620 630 640 650
DGGVIVEQGN HDELMREKGI YFKLVMTQTR GNEIEPGNNA YGSQSDTDAS
660 670 680 690 700
ELTSEESKSP LIRRSIYRSV HRKQDQERRL SMKEAVDEDV PLVSFWRILN
710 720 730 740 750
LNLSEWPYLL VGVLCAVING CIQPVFAIVF SRIVGVFSRD DDHETKRQNC
760 770 780 790 800
NLFSLFFLVM GLISFVTYFF QGFTFGKAGE ILTKRVRYMV FKSMLRQDIS
810 820 830 840 850
WFDDHKNSTG SLTTRLASDA SSVKGAMGAR LAVVTQNVAN LGTGVILSLV
860 870 880 890 900
YGWQLTLLLV VIIPLIVLGG IIEMKLLSGQ ALKDKKQLEI SGKIATEAIE
910 920 930 940 950
NFRTIVSLTR EQKFETMYAQ SLQVPYRNAM KKAHVFGITF SFTQAMMYFS
960 970 980 990 1000
YAACFRFGAY LVAQQLMTFE NVMLVFSAVV FGAMAAGNTS SFAPDYAKAK
1010 1020 1030 1040 1050
VSASHIIRII EKTPEIDSYS TEGLKPTLLE GNVKFNGVQF NYPTRPNIPV
1060 1070 1080 1090 1100
LQGLSLEVKK GQTLALVGSS GCGKSTVVQL LERFYDPMAG SVFLDGKEIK
1110 1120 1130 1140 1150
QLNVQWLRAH LGIVSQEPIL FDCSIAENIA YGDNSRAVSH EEIVRAAKEA
1160 1170 1180 1190 1200
NIHQFIDSLP DKYNTRVGDK GTQLSGGQKQ RIAIARALVR QPHILLLDEA
1210 1220 1230 1240 1250
TSALDTESEK VVQEALDKAR EGRTCIVIAH RLSTIQNADL IVVIENGKVK
1260 1270
EHGTHQQLLA QKGIYFSMVQ AGAKRS
Length:1,276
Mass (Da):140,994
Last modified:January 1, 1988 - v1
Checksum:i1804D0F011B0FF4E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JF49A0A0G2JF49_MOUSE
Multidrug resistance protein 1B
Abcb1b
205Annotation score:
A0A0G2JGL4A0A0G2JGL4_MOUSE
Multidrug resistance protein 1B
Abcb1b
106Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14757 mRNA Translation: AAA79005.1
M60348 Genomic DNA Translation: AAA39513.1
CCDSiCCDS19085.1
PIRiA33719 DVMS1
RefSeqiNP_035205.1, NM_011075.2
UniGeneiMm.146649
Mm.389059

Genome annotation databases

EnsembliENSMUST00000009058; ENSMUSP00000009058; ENSMUSG00000028970
GeneIDi18669
KEGGimmu:18669
UCSCiuc008wko.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14757 mRNA Translation: AAA79005.1
M60348 Genomic DNA Translation: AAA39513.1
CCDSiCCDS19085.1
PIRiA33719 DVMS1
RefSeqiNP_035205.1, NM_011075.2
UniGeneiMm.146649
Mm.389059

3D structure databases

ProteinModelPortaliP06795
SMRiP06795
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP06795, 1 interactor
MINTiP06795
STRINGi10090.ENSMUSP00000009058

Chemistry databases

BindingDBiP06795
ChEMBLiCHEMBL3467

PTM databases

iPTMnetiP06795
PhosphoSitePlusiP06795
SwissPalmiP06795

Proteomic databases

EPDiP06795
MaxQBiP06795
PaxDbiP06795
PRIDEiP06795

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000009058; ENSMUSP00000009058; ENSMUSG00000028970
GeneIDi18669
KEGGimmu:18669
UCSCiuc008wko.2 mouse

Organism-specific databases

CTDi18669
MGIiMGI:97568 Abcb1b

Phylogenomic databases

eggNOGiKOG0055 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00530000062896
HOVERGENiHBG080809
InParanoidiP06795
KOiK05658
OMAiFIMYWKT
OrthoDBiEOG091G0HVA
PhylomeDBiP06795
TreeFamiTF105193

Enzyme and pathway databases

ReactomeiR-MMU-382556 ABC-family proteins mediated transport
SABIO-RKiP06795

Miscellaneous databases

PROiPR:P06795
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028970 Expressed in 176 organ(s), highest expression level in adrenal gland
ExpressionAtlasiP06795 baseline and differential
GenevisibleiP06795 MM

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
IPR039421 Type_I_exporter
PANTHERiPTHR24221 PTHR24221, 1 hit
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMDR1B_MOUSE
AccessioniPrimary (citable) accession number: P06795
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 7, 2018
This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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