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UniProtKB - P06781 (RHO2_YEAST)
Protein
GTP-binding protein RHO2
Gene
RHO2
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Miscellaneous
Present with 3870 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 14 – 21 | GTPBy similarity | 8 | |
Nucleotide bindingi | 61 – 65 | GTPBy similarity | 5 | |
Nucleotide bindingi | 119 – 122 | GTPBy similarity | 4 |
GO - Molecular functioni
- GTPase activity Source: SGD
- GTP binding Source: GO_Central
- protein kinase binding Source: GO_Central
GO - Biological processi
- actin filament organization Source: GO_Central
- cortical cytoskeleton organization Source: GO_Central
- establishment of cell polarity Source: SGD
- establishment or maintenance of cell polarity Source: GO_Central
- fungal-type cell wall organization Source: SGD
- microtubule-based process Source: SGD
- regulation of actin cytoskeleton organization Source: GO_Central
- regulation of cell shape Source: GO_Central
- small GTPase mediated signal transduction Source: SGD
Keywordsi
Molecular function | Hydrolase |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-SCE-416482, G alpha (12/13) signalling events R-SCE-5625740, RHO GTPases activate PKNs R-SCE-6798695, Neutrophil degranulation R-SCE-9013026, RHOB GTPase cycle R-SCE-9013106, RHOC GTPase cycle R-SCE-9013405, RHOD GTPase cycle R-SCE-9035034, RHOF GTPase cycle R-SCE-9696264, RND3 GTPase cycle R-SCE-9696270, RND2 GTPase cycle R-SCE-9696273, RND1 GTPase cycle |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:RHO2 Ordered Locus Names:YNL090W ORF Names:N2237 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000005034, RHO2 |
VEuPathDBi | FungiDB:YNL090W |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated
Cytoskeleton
- cytoskeleton Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cell cortex Source: GO_Central
- cell periphery Source: SGD
- cell projection Source: GO_Central
- cytoplasmic vesicle Source: GO_Central
- membrane Source: SGD
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000198946 | 1 – 189 | GTP-binding protein RHO2Add BLAST | 189 | |
PropeptideiPRO_0000281276 | 190 – 192 | Removed in mature formBy similarity | 3 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 188 | S-palmitoyl cysteine1 Publication | 1 | |
Modified residuei | 189 | Cysteine methyl esterBy similarity | 1 | |
Lipidationi | 189 | S-geranylgeranyl cysteineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, Methylation, Palmitate, PrenylationProteomic databases
MaxQBi | P06781 |
PaxDbi | P06781 |
PRIDEi | P06781 |
PTM databases
iPTMneti | P06781 |
SwissPalmi | P06781 |
Interactioni
Subunit structurei
Interacts with BEM4.
1 PublicationGO - Molecular functioni
- protein kinase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 35734, 161 interactors |
DIPi | DIP-5750N |
IntActi | P06781, 14 interactors |
STRINGi | 4932.YNL090W |
Miscellaneous databases
RNActi | P06781, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 36 – 44 | Effector regionBy similarity | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0393, Eukaryota |
HOGENOMi | CLU_041217_21_2_1 |
InParanoidi | P06781 |
OMAi | NDNVMRR |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR003578, Small_GTPase_Rho |
PANTHERi | PTHR24072, PTHR24072, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SMARTi | View protein in SMART SM00174, RHO, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51420, RHO, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P06781-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEKAVRRKL VIIGDGACGK TSLLYVFTLG KFPEQYHPTV FENYVTDCRV
60 70 80 90 100
DGIKVSLTLW DTAGQEEYER LRPFSYSKAD IILIGFAVDN FESLINARTK
110 120 130 140 150
WADEALRYCP DAPIVLVGLK KDLRQEAHFK ENATDEMVPI EDAKQVARAI
160 170 180 190
GAKKYMECSA LTGEGVDDVF EVATRTSLLM KKEPGANCCI IL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 48 | C → S in AAA34978 (PubMed:3543936).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M15190 Genomic DNA Translation: AAA34978.1 AF458969 Genomic DNA Translation: AAM00517.1 AF458970 Genomic DNA Translation: AAM00523.1 AF458971 Genomic DNA Translation: AAM00529.1 AF458972 Genomic DNA Translation: AAM00535.1 AF458973 Genomic DNA Translation: AAM00541.1 AF458974 Genomic DNA Translation: AAM00547.1 AF458976 Genomic DNA Translation: AAM00559.1 AF458978 Genomic DNA Translation: AAM00571.1 AF458981 Genomic DNA Translation: AAM00589.1 DQ115393 Genomic DNA Translation: AAZ22518.1 X89016 Genomic DNA Translation: CAA61421.1 Z71366 Genomic DNA Translation: CAA95965.1 BK006947 Genomic DNA Translation: DAA10456.1 |
PIRi | S57533, TVBYH2 |
RefSeqi | NP_014309.3, NM_001182928.3 |
Genome annotation databases
EnsemblFungii | YNL090W_mRNA; YNL090W; YNL090W |
GeneIDi | 855634 |
KEGGi | sce:YNL090W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M15190 Genomic DNA Translation: AAA34978.1 AF458969 Genomic DNA Translation: AAM00517.1 AF458970 Genomic DNA Translation: AAM00523.1 AF458971 Genomic DNA Translation: AAM00529.1 AF458972 Genomic DNA Translation: AAM00535.1 AF458973 Genomic DNA Translation: AAM00541.1 AF458974 Genomic DNA Translation: AAM00547.1 AF458976 Genomic DNA Translation: AAM00559.1 AF458978 Genomic DNA Translation: AAM00571.1 AF458981 Genomic DNA Translation: AAM00589.1 DQ115393 Genomic DNA Translation: AAZ22518.1 X89016 Genomic DNA Translation: CAA61421.1 Z71366 Genomic DNA Translation: CAA95965.1 BK006947 Genomic DNA Translation: DAA10456.1 |
PIRi | S57533, TVBYH2 |
RefSeqi | NP_014309.3, NM_001182928.3 |
3D structure databases
AlphaFoldDBi | P06781 |
SMRi | P06781 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 35734, 161 interactors |
DIPi | DIP-5750N |
IntActi | P06781, 14 interactors |
STRINGi | 4932.YNL090W |
PTM databases
iPTMneti | P06781 |
SwissPalmi | P06781 |
Proteomic databases
MaxQBi | P06781 |
PaxDbi | P06781 |
PRIDEi | P06781 |
Genome annotation databases
EnsemblFungii | YNL090W_mRNA; YNL090W; YNL090W |
GeneIDi | 855634 |
KEGGi | sce:YNL090W |
Organism-specific databases
SGDi | S000005034, RHO2 |
VEuPathDBi | FungiDB:YNL090W |
Phylogenomic databases
eggNOGi | KOG0393, Eukaryota |
HOGENOMi | CLU_041217_21_2_1 |
InParanoidi | P06781 |
OMAi | NDNVMRR |
Enzyme and pathway databases
Reactomei | R-SCE-416482, G alpha (12/13) signalling events R-SCE-5625740, RHO GTPases activate PKNs R-SCE-6798695, Neutrophil degranulation R-SCE-9013026, RHOB GTPase cycle R-SCE-9013106, RHOC GTPase cycle R-SCE-9013405, RHOD GTPase cycle R-SCE-9035034, RHOF GTPase cycle R-SCE-9696264, RND3 GTPase cycle R-SCE-9696270, RND2 GTPase cycle R-SCE-9696273, RND1 GTPase cycle |
Miscellaneous databases
PROi | PR:P06781 |
RNActi | P06781, protein |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase IPR003578, Small_GTPase_Rho |
PANTHERi | PTHR24072, PTHR24072, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SMARTi | View protein in SMART SM00174, RHO, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51420, RHO, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RHO2_YEAST | |
Accessioni | P06781Primary (citable) accession number: P06781 Secondary accession number(s): D6W190, Q45TZ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | February 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 197 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome XIV
Yeast (Saccharomyces cerevisiae) chromosome XIV: entries and gene names - SIMILARITY comments
Index of protein domains and families