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Protein

Retinol-binding protein 2

Gene

Rbp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Intracellular transport of retinol.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei41Retinoic acidBy similarity1
Binding sitei109Retinoic acid1

GO - Molecular functioni

  • retinal binding Source: UniProtKB-KW
  • retinol binding Source: RGD

GO - Biological processi

  • retinol metabolic process Source: RGD

Keywordsi

Biological processTransport
LigandRetinol-binding, Vitamin A

Enzyme and pathway databases

ReactomeiR-RNO-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Retinol-binding protein 2
Alternative name(s):
Cellular retinol-binding protein II
Short name:
CRBP-II
Gene namesi
Name:Rbp2
Synonyms:Crbpii
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi3544 Rbp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000673982 – 134Retinol-binding protein 2Add BLAST133

Proteomic databases

PaxDbiP06768

Expressioni

Gene expression databases

BgeeiENSRNOG00000013932 Expressed in 6 organ(s), highest expression level in colon
GenevisibleiP06768 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018755

Structurei

Secondary structure

1134
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP06768
SMRiP06768
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06768

Family & Domainsi

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004831
HOVERGENiHBG005633
InParanoidiP06768
KOiK14622
OMAiENRGWKQ
OrthoDBiEOG091G0QSV
PhylomeDBiP06768
TreeFamiTF316894

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06768-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTKDQNGTWE MESNENFEGY MKALDIDFAT RKIAVRLTQT KIIVQDGDNF
60 70 80 90 100
KTKTNSTFRN YDLDFTVGVE FDEHTKGLDG RNVKTLVTWE GNTLVCVQKG
110 120 130
EKENRGWKQW VEGDKLYLEL TCGDQVCRQV FKKK
Length:134
Mass (Da):15,585
Last modified:January 23, 2007 - v3
Checksum:i68491539A0115208
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13949 mRNA Translation: AAA42022.1
M16402, M16400, M16401 Genomic DNA Translation: AAA40963.1 Sequence problems.
PIRiA92626 A29065
RefSeqiNP_036772.2, NM_012640.2
XP_006243669.1, XM_006243607.1
XP_017450964.1, XM_017595475.1
UniGeneiRn.9828

Genome annotation databases

EnsembliENSRNOT00000018755; ENSRNOP00000018755; ENSRNOG00000013932
GeneIDi24710
KEGGirno:24710
UCSCiRGD:3544 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13949 mRNA Translation: AAA42022.1
M16402, M16400, M16401 Genomic DNA Translation: AAA40963.1 Sequence problems.
PIRiA92626 A29065
RefSeqiNP_036772.2, NM_012640.2
XP_006243669.1, XM_006243607.1
XP_017450964.1, XM_017595475.1
UniGeneiRn.9828

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B4MNMR-A1-134[»]
1EIINMR-A1-134[»]
1OPAX-ray1.90A/B1-134[»]
1OPBX-ray1.90A/B/C/D1-134[»]
ProteinModelPortaliP06768
SMRiP06768
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018755

Proteomic databases

PaxDbiP06768

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018755; ENSRNOP00000018755; ENSRNOG00000013932
GeneIDi24710
KEGGirno:24710
UCSCiRGD:3544 rat

Organism-specific databases

CTDi5948
RGDi3544 Rbp2

Phylogenomic databases

eggNOGiKOG4015 Eukaryota
ENOG4111US8 LUCA
GeneTreeiENSGT00760000118898
HOGENOMiHOG000004831
HOVERGENiHBG005633
InParanoidiP06768
KOiK14622
OMAiENRGWKQ
OrthoDBiEOG091G0QSV
PhylomeDBiP06768
TreeFamiTF316894

Enzyme and pathway databases

ReactomeiR-RNO-975634 Retinoid metabolism and transport

Miscellaneous databases

EvolutionaryTraceiP06768
PROiPR:P06768

Gene expression databases

BgeeiENSRNOG00000013932 Expressed in 6 organ(s), highest expression level in colon
GenevisibleiP06768 RN

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR000463 Fatty_acid-bd
IPR031259 ILBP
IPR000566 Lipocln_cytosolic_FA-bd_dom
PANTHERiPTHR11955 PTHR11955, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR00178 FATTYACIDBP
SUPFAMiSSF50814 SSF50814, 1 hit
PROSITEiView protein in PROSITE
PS00214 FABP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRET2_RAT
AccessioniPrimary (citable) accession number: P06768
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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