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Protein

Protachykinin-1

Gene

Tac1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.

GO - Molecular functioni

  • substance P receptor binding Source: RGD

GO - Biological processi

  • associative learning Source: RGD
  • cellular response to nerve growth factor stimulus Source: Ensembl
  • chemical synaptic transmission Source: UniProtKB-KW
  • inflammatory response Source: Ensembl
  • long-term memory Source: RGD
  • negative regulation of heart rate Source: RGD
  • neuropeptide signaling pathway Source: UniProtKB-KW
  • positive regulation of action potential Source: RGD
  • positive regulation of acute inflammatory response Source: RGD
  • positive regulation of corticosterone secretion Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of epithelial cell migration Source: RGD
  • positive regulation of lymphocyte proliferation Source: RGD
  • positive regulation of ossification Source: RGD
  • positive regulation of renal sodium excretion Source: RGD
  • positive regulation of saliva secretion Source: RGD
  • positive regulation of stress fiber assembly Source: RGD
  • positive regulation of synaptic transmission, cholinergic Source: RGD
  • positive regulation of synaptic transmission, GABAergic Source: RGD
  • regulation of blood pressure Source: RGD
  • response to hormone Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to morphine Source: RGD
  • response to pain Source: Ensembl
  • sensory perception of pain Source: Ensembl
  • tachykinin receptor signaling pathway Source: GO_Central

Keywordsi

Molecular functionNeuropeptide, Neurotransmitter

Enzyme and pathway databases

ReactomeiR-RNO-380095 Tachykinin receptors bind tachykinins
R-RNO-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Protachykinin-1
Alternative name(s):
PPT
Cleaved into the following 5 chains:
Neurokinin A
Short name:
NKA
Alternative name(s):
Neuromedin L
Substance K
Neuropeptide K
Short name:
NPK
Gene namesi
Name:Tac1
Synonyms:Nka, Nkna, Tac2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi3807 Tac1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000003355020 – 56Sequence analysisAdd BLAST37
PeptideiPRO_000003355158 – 68Substance PAdd BLAST11
PeptideiPRO_000003355272 – 107Neuropeptide KAdd BLAST36
PeptideiPRO_000003355372 – 73Neuropeptide gamma, 1st part2
PeptideiPRO_000003355489 – 107Neuropeptide gamma, 2nd partAdd BLAST19
PeptideiPRO_000003355598 – 107Neurokinin A10
PeptideiPRO_0000033556111 – 126C-terminal-flanking peptideAdd BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei68Methionine amideBy similarity1
Modified residuei107Methionine amideBy similarity1

Post-translational modificationi

The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei59 – 60Cleavage; by FAPBy similarity2

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP06767
PRIDEiP06767

Miscellaneous databases

PMAP-CutDBiP06767

Expressioni

Gene expression databases

BgeeiENSRNOG00000007374
GenevisibleiP06767 RN

Interactioni

GO - Molecular functioni

  • substance P receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009888

Structurei

3D structure databases

ProteinModelPortaliP06767
SMRiP06767
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWZZ Eukaryota
ENOG4112BW1 LUCA
GeneTreeiENSGT00390000002457
HOGENOMiHOG000082514
HOVERGENiHBG000127
InParanoidiP06767
KOiK05239
OMAiQITRKRH
OrthoDBiEOG091G0Y2V
PhylomeDBiP06767
TreeFamiTF333405

Family and domain databases

InterProiView protein in InterPro
IPR013055 Tachy_Neuro_lke_CS
IPR008215 Tachykinin_dom
IPR008216 Tachykinin_fam
PANTHERiPTHR11250 PTHR11250, 1 hit
PRINTSiPR01829 PROTACHYKNIN
SMARTiView protein in SMART
SM00203 TK, 2 hits
PROSITEiView protein in PROSITE
PS00267 TACHYKININ, 2 hits

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Beta (identifier: P06767-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKILVAVAVF FLVSTQLFAE EIGANDDLNY WSDWSDSDQI KEAMPEPFEH
60 70 80 90 100
LLQRIARRPK PQQFFGLMGK RDADSSIEKQ VALLKALYGH GQISHKRHKT
110 120 130
DSFVGLMGKR ALNSVAYERS AMQNYERRRK
Length:130
Mass (Da):15,001
Last modified:May 30, 2000 - v2
Checksum:iB22EFE860DCCD75A
GO
Isoform Alpha (identifier: P06767-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-114: Missing.
     115-115: V → M

Show »
Length:112
Mass (Da):13,034
Checksum:i5B21D8FED8E0D76E
GO
Isoform Gamma (identifier: P06767-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-88: Missing.

Show »
Length:115
Mass (Da):13,341
Checksum:i83E021DCFF1F01F0
GO
Isoform Delta (identifier: P06767-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     74-88: Missing.
     97-114: Missing.
     115-115: V → M

Show »
Length:97
Mass (Da):11,374
Checksum:iC2A5A1F3565232A2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00638074 – 88Missing in isoform Gamma and isoform Delta. 4 PublicationsAdd BLAST15
Alternative sequenceiVSP_00638197 – 114Missing in isoform Alpha and isoform Delta. 3 PublicationsAdd BLAST18
Alternative sequenceiVSP_006382115V → M in isoform Alpha and isoform Delta. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M34162
, M34159, M34160, M34161 Genomic DNA Translation: AAA41926.1
M34184 mRNA Translation: AAA41925.1
M34183 mRNA Translation: AAA41929.1
M15191 mRNA Translation: AAA41928.1
M14312 mRNA Translation: AAA41927.1
L07328 Genomic DNA Translation: AAA41924.1
X56306 mRNA Translation: CAA39752.1
S72369 mRNA Translation: AAB31499.1
PIRiA37163 SPRTB
B26590 SPRTA
S12958
RefSeqiNP_001118240.1, NM_001124768.1 [P06767-3]
NP_001118241.1, NM_001124769.1 [P06767-4]
NP_001118242.1, NM_001124770.1 [P06767-2]
NP_036798.1, NM_012666.2 [P06767-1]
UniGeneiRn.1920

Genome annotation databases

EnsembliENSRNOT00000009888; ENSRNOP00000009888; ENSRNOG00000007374 [P06767-1]
ENSRNOT00000034719; ENSRNOP00000033246; ENSRNOG00000007374 [P06767-3]
ENSRNOT00000052333; ENSRNOP00000048764; ENSRNOG00000007374 [P06767-2]
GeneIDi24806
KEGGirno:24806
UCSCiRGD:3807 rat [P06767-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTKN1_RAT
AccessioniPrimary (citable) accession number: P06767
Secondary accession number(s): P08856
, P08857, P22356, Q6LD93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: May 30, 2000
Last modified: May 23, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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