UniProtKB - P06753 (TPM3_HUMAN)
Tropomyosin alpha-3 chain
TPM3
Functioni
Caution
GO - Molecular functioni
- actin filament binding Source: GO_Central
GO - Biological processi
- actin filament organization Source: GO_Central
- muscle contraction Source: GO_Central
- muscle filament sliding Source: Reactome
Keywordsi
Molecular function | Actin-binding, Muscle protein |
Enzyme and pathway databases
PathwayCommonsi | P06753 |
Reactomei | R-HSA-390522, Striated Muscle Contraction R-HSA-445355, Smooth Muscle Contraction |
SIGNORi | P06753 |
Names & Taxonomyi
Protein namesi | Recommended name: Tropomyosin alpha-3 chainAlternative name(s): Gamma-tropomyosin Tropomyosin-3 Tropomyosin-5 Short name: hTM5 |
Gene namesi | Name:TPM3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12012, TPM3 |
MIMi | 164970, gene 191030, gene |
neXtProti | NX_P06753 |
VEuPathDBi | HostDB:ENSG00000143549.19 |
Subcellular locationi
Cytoskeleton
- cytoskeleton Curated
Cytoskeleton
- actin cytoskeleton Source: HPA
- actin filament Source: GO_Central
- cytoskeleton Source: UniProtKB
- muscle thin filament tropomyosin Source: UniProtKB
- stress fiber Source: MGI
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPathology & Biotechi
Involvement in diseasei
Nemaline myopathy 1 (NEM1)4 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_013460 | 9 | M → R in NEM1; decrease in the sensitivity of contraction to activating calcium. 2 PublicationsCorresponds to variant dbSNP:rs80358247EnsemblClinVar. | 1 | |
Natural variantiVAR_071500 | 88 | S → F in NEM1 and CAPM1. 1 Publication | 1 | |
Natural variantiVAR_070067 | 168 | R → C in CFTD, CAPM1 and NEM1; also found in patients with undefined congenital myopathy. 3 PublicationsCorresponds to variant dbSNP:rs121964854EnsemblClinVar. | 1 | |
Natural variantiVAR_070069 | 168 | R → H in NEM1, CAPM1 and CFTD; also found in patients with undefined congenital myopathy. 6 PublicationsCorresponds to variant dbSNP:rs121964852EnsemblClinVar. | 1 |
Myopathy, congenital, with fiber-type disproportion (CFTD)4 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071499 | 4 | A → V in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474711EnsemblClinVar. | 1 | |
Natural variantiVAR_071502 | 91 | R → P in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474713EnsemblClinVar. | 1 | |
Natural variantiVAR_070066 | 100 | L → M in CFTD. 1 PublicationCorresponds to variant dbSNP:rs121964853EnsemblClinVar. | 1 | |
Natural variantiVAR_071503 | 100 | L → V in CFTD. 1 PublicationCorresponds to variant dbSNP:rs121964853EnsemblClinVar. | 1 | |
Natural variantiVAR_070067 | 168 | R → C in CFTD, CAPM1 and NEM1; also found in patients with undefined congenital myopathy. 3 PublicationsCorresponds to variant dbSNP:rs121964854EnsemblClinVar. | 1 | |
Natural variantiVAR_070068 | 168 | R → G in CFTD. 1 PublicationCorresponds to variant dbSNP:rs121964854EnsemblClinVar. | 1 | |
Natural variantiVAR_070069 | 168 | R → H in NEM1, CAPM1 and CFTD; also found in patients with undefined congenital myopathy. 6 PublicationsCorresponds to variant dbSNP:rs121964852EnsemblClinVar. | 1 | |
Natural variantiVAR_070070 | 169 | K → E in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474715EnsemblClinVar. | 1 | |
Natural variantiVAR_071506 | 174 | E → A in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474716EnsemblClinVar. | 1 | |
Natural variantiVAR_071507 | 241 | E → K in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474717EnsemblClinVar. | 1 | |
Natural variantiVAR_070071 | 245 | R → G in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474718EnsemblClinVar. | 1 |
Cap myopathy 1 (CAPM1)5 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071500 | 88 | S → F in NEM1 and CAPM1. 1 Publication | 1 | |
Natural variantiVAR_071504 | 149 | L → I in CAPM1. 1 Publication | 1 | |
Natural variantiVAR_071505 | 151 | E → A in CAPM1. 1 Publication | 1 | |
Natural variantiVAR_071508 | 245 | R → I in CAPM1. 1 PublicationCorresponds to variant dbSNP:rs797046047EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Nemaline myopathy, Proto-oncogeneOrganism-specific databases
DisGeNETi | 7170 |
GeneReviewsi | TPM3 |
MalaCardsi | TPM3 |
MIMi | 255310, phenotype 609284, phenotype |
OpenTargetsi | ENSG00000143549 |
Orphaneti | 171881, Cap myopathy 171439, Childhood-onset nemaline myopathy 2020, Congenital fiber-type disproportion myopathy 476406, Congenital generalized hypercontractile muscle stiffness syndrome 178342, Inflammatory myofibroblastic tumor 171433, Intermediate nemaline myopathy |
PharmGKBi | PA36692 |
Miscellaneous databases
Pharosi | P06753, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3804747 |
DrugBanki | DB12695, Phenethyl Isothiocyanate |
Genetic variation databases
BioMutai | TPM3 |
DMDMi | 519668659 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | ||||
ChainiPRO_0000205632 | 2 – 285 | Tropomyosin alpha-3 chainAdd BLAST | 284 | ||
Isoform 2 (identifier: P06753-2) | |||||
Initiator methioninei | RemovedCurated | ||||
Isoform 3 (identifier: P06753-3) | |||||
Initiator methioninei | RemovedCurated |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 2 | N-acetylmethionineBy similarity | 1 | ||
Modified residuei | 54 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 62 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 88 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 109 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 207 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 216 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 253 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 262 | PhosphotyrosineBy similarity | 1 | ||
Modified residuei | 272 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 283 | PhosphothreonineBy similarity | 1 | ||
Modified residuei | 284 | PhosphoserineBy similarity | 1 | ||
Isoform 2 (identifier: P06753-2) | |||||
Modified residuei | 2 | N-acetylalanineCurated | 1 | ||
Modified residuei | 177 | N6-acetyllysineCombined sources | 1 | ||
Modified residuei | 215 | N6-acetyllysineCombined sources | 1 | ||
Isoform 3 (identifier: P06753-3) | |||||
Modified residuei | 2 | N-acetylalanineCurated | 1 | ||
Modified residuei | 177 | N6-acetyllysineCombined sources | 1 | ||
Isoform 7 (identifier: P06753-7) | |||||
Modified residuei | 125 | N6-acetyllysineCombined sources | 1 | ||
Isoform 6 (identifier: P06753-6) | |||||
Modified residuei | 177 | N6-acetyllysineCombined sources | 1 | ||
Isoform 5 (identifier: P06753-5) | |||||
Modified residuei | 215 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P06753 |
jPOSTi | P06753 |
MassIVEi | P06753 |
MaxQBi | P06753 |
PaxDbi | P06753 |
PeptideAtlasi | P06753 |
PRIDEi | P06753 |
ProteomicsDBi | 51930 [P06753-1] 51931 [P06753-2] 51932 [P06753-3] 65387 65390 65392 65394 |
2D gel databases
DOSAC-COBS-2DPAGEi | P06753 |
SWISS-2DPAGEi | P06753 |
PTM databases
iPTMneti | P06753 |
MetOSitei | P06753 |
PhosphoSitePlusi | P06753 |
SwissPalmi | P06753 |
Expressioni
Gene expression databases
Bgeei | ENSG00000143549, Expressed in muscle of leg and 163 other tissues |
ExpressionAtlasi | P06753, baseline and differential |
Genevisiblei | P06753, HS |
Organism-specific databases
HPAi | ENSG00000143549, Tissue enhanced (skeletal muscle, tongue) |
Interactioni
Subunit structurei
Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain (By similarity).
Interacts with TMOD1 (PubMed:8002995).
By similarity1 PublicationBinary interactionsi
Hide detailsP06753
Isoform 2 [P06753-2]
With | #Exp. | IntAct |
---|---|---|
ATN1 [Q86V38] | 3 | EBI-10977875,EBI-11954292 |
ATXN1 [P54253] | 3 | EBI-10977875,EBI-930964 |
BACE2 [Q9Y5Z0] | 3 | EBI-10977875,EBI-11282723 |
KLK6 [Q92876] | 3 | EBI-10977875,EBI-2432309 |
GO - Molecular functioni
- actin filament binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 113023, 190 interactors |
IntActi | P06753, 102 interactors |
MINTi | P06753 |
STRINGi | 9606.ENSP00000357516 |
Miscellaneous databases
RNActi | P06753, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P06753 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 1 – 285 | By similarityAdd BLAST | 285 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG1003, Eukaryota |
GeneTreei | ENSGT01010000222381 |
HOGENOMi | CLU_055027_3_0_1 |
InParanoidi | P06753 |
OMAi | EKKAADX |
OrthoDBi | 1576041at2759 |
PhylomeDBi | P06753 |
TreeFami | TF351519 |
Family and domain databases
InterProi | View protein in InterPro IPR000533, Tropomyosin |
Pfami | View protein in Pfam PF00261, Tropomyosin, 1 hit |
PRINTSi | PR00194, TROPOMYOSIN |
PROSITEi | View protein in PROSITE PS00326, TROPOMYOSIN, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMEAIKKKMQ MLKLDKENAL DRAEQAEAEQ KQAEERSKQL EDELAAMQKK
60 70 80 90 100
LKGTEDELDK YSEALKDAQE KLELAEKKAA DAEAEVASLN RRIQLVEEEL
110 120 130 140 150
DRAQERLATA LQKLEEAEKA ADESERGMKV IENRALKDEE KMELQEIQLK
160 170 180 190 200
EAKHIAEEAD RKYEEVARKL VIIEGDLERT EERAELAESK CSELEEELKN
210 220 230 240 250
VTNNLKSLEA QAEKYSQKED KYEEEIKILT DKLKEAETRA EFAERSVAKL
260 270 280
EKTIDDLEDE LYAQKLKYKA ISEELDHALN DMTSI
The sequence of this isoform differs from the canonical sequence as follows:
1-81: MMEAIKKKMQ...LELAEKKAAD → MAGITTIEAV...VEGERRAREQ
190-212: KCSELEEELKNVTNNLKSLEAQA → RCREMDEQIRLMDQNLKCLSAAE
260-285: ELYAQKLKYKAISEELDHALNDMTSI → KLKCTKEEHLCTQRMLDQTLLDLNEM
The sequence of this isoform differs from the canonical sequence as follows:
1-81: MMEAIKKKMQ...LELAEKKAAD → MAGITTIEAV...VEGERRAREQ
190-212: KCSELEEELKNVTNNLKSLEAQA → RCREMDEQIRLMDQNLKCLSAAE
259-285: DELYAQKLKYKAISEELDHALNDMTSI → ERLYSQLERNRLLSNELKLTLHDLCD
The sequence of this isoform differs from the canonical sequence as follows:
1-2: MM → MAGITTI
5-21: IKKKMQMLKLDKENALD → VKRKIQVLQQQADDAEE
25-81: QAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAAD → RLQREVEGERRAREQ
259-260: DE → ER
263-285: AQKLKYKAISEELDHALNDMTSI → SQLERNRLLSNELKLTLHDLCD
The sequence of this isoform differs from the canonical sequence as follows:
1-2: MM → MAGITTI
5-21: IKKKMQMLKLDKENALD → VKRKIQVLQQQADDAEE
25-81: QAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAAD → RLQREVEGERRAREQ
260-285: ELYAQKLKYKAISEELDHALNDMTSI → KLKCTKEEHLCTQRMLDQTLLDLNEM
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KN67 | J3KN67_HUMAN | Tropomyosin alpha-3 chain | TPM3 | 285 | Annotation score: | ||
A0A2R2Y2Q3 | A0A2R2Y2Q3_HUMAN | Tropomyosin 3 nu | TPM3 TPM3nu | 285 | Annotation score: | ||
A0A494C0P6 | A0A494C0P6_HUMAN | Tropomyosin alpha-3 chain | TPM3 | 214 | Annotation score: | ||
Q5VU61 | Q5VU61_HUMAN | Tropomyosin alpha-3 chain | TPM3 | 49 | Annotation score: | ||
A0A087WWU8 | A0A087WWU8_HUMAN | Tropomyosin alpha-3 chain | TPM3 | 227 | Annotation score: | ||
A0A494C034 | A0A494C034_HUMAN | Tropomyosin alpha-3 chain | TPM3 | 97 | Annotation score: | ||
A0A494C0G0 | A0A494C0G0_HUMAN | Tropomyosin alpha-3 chain | TPM3 | 87 | Annotation score: | ||
D6R904 | D6R904_HUMAN | Tropomyosin alpha-3 chain | TPM3 | 95 | Annotation score: | ||
D6RGJ6 | D6RGJ6_HUMAN | Tropomyosin alpha-3 chain | TPM3 | 75 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Sequence conflicti | 150 | K → E in CAA27243 (PubMed:12574106).Curated | 1 | ||
Isoform 2 (identifier: P06753-2) | |||||
Sequence conflicti | 33 | R → Q in ABC40673 (PubMed:16201836).Curated | 1 | ||
Sequence conflicti | 43 | E → K in ABC40673 (PubMed:16201836).Curated | 1 | ||
Sequence conflicti | 66 | A → P in ABC40673 (PubMed:16201836).Curated | 1 | ||
Sequence conflicti | 85 | D → G in ABC40673 (PubMed:16201836).Curated | 1 | ||
Sequence conflicti | 110 | I → L in ABC40673 (PubMed:16201836).Curated | 1 | ||
Sequence conflicti | 135 | I → T in ABC40673 (PubMed:16201836).Curated | 1 | ||
Sequence conflicti | 150 | A → T in ABC40673 (PubMed:16201836).Curated | 1 | ||
Sequence conflicti | 192 | L → F in ABC40673 (PubMed:16201836).Curated | 1 | ||
Sequence conflicti | 196 | L → P in ABC40673 (PubMed:16201836).Curated | 1 | ||
Sequence conflicti | 202 | R → C in ABC40673 (PubMed:16201836).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071499 | 4 | A → V in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474711EnsemblClinVar. | 1 | |
Natural variantiVAR_013460 | 9 | M → R in NEM1; decrease in the sensitivity of contraction to activating calcium. 2 PublicationsCorresponds to variant dbSNP:rs80358247EnsemblClinVar. | 1 | |
Natural variantiVAR_071500 | 88 | S → F in NEM1 and CAPM1. 1 Publication | 1 | |
Natural variantiVAR_071501 | 91 | R → C Probable disease-associated variant found in patients with undefined congenital myopathy. 1 Publication | 1 | |
Natural variantiVAR_071502 | 91 | R → P in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474713EnsemblClinVar. | 1 | |
Natural variantiVAR_070066 | 100 | L → M in CFTD. 1 PublicationCorresponds to variant dbSNP:rs121964853EnsemblClinVar. | 1 | |
Natural variantiVAR_071503 | 100 | L → V in CFTD. 1 PublicationCorresponds to variant dbSNP:rs121964853EnsemblClinVar. | 1 | |
Natural variantiVAR_071504 | 149 | L → I in CAPM1. 1 Publication | 1 | |
Natural variantiVAR_071505 | 151 | E → A in CAPM1. 1 Publication | 1 | |
Natural variantiVAR_070067 | 168 | R → C in CFTD, CAPM1 and NEM1; also found in patients with undefined congenital myopathy. 3 PublicationsCorresponds to variant dbSNP:rs121964854EnsemblClinVar. | 1 | |
Natural variantiVAR_070068 | 168 | R → G in CFTD. 1 PublicationCorresponds to variant dbSNP:rs121964854EnsemblClinVar. | 1 | |
Natural variantiVAR_070069 | 168 | R → H in NEM1, CAPM1 and CFTD; also found in patients with undefined congenital myopathy. 6 PublicationsCorresponds to variant dbSNP:rs121964852EnsemblClinVar. | 1 | |
Natural variantiVAR_070070 | 169 | K → E in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474715EnsemblClinVar. | 1 | |
Natural variantiVAR_071506 | 174 | E → A in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474716EnsemblClinVar. | 1 | |
Natural variantiVAR_071507 | 241 | E → K in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474717EnsemblClinVar. | 1 | |
Natural variantiVAR_070071 | 245 | R → G in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474718EnsemblClinVar. | 1 | |
Natural variantiVAR_071508 | 245 | R → I in CAPM1. 1 PublicationCorresponds to variant dbSNP:rs797046047EnsemblClinVar. | 1 | |
Natural variantiVAR_071509 | 253 | T → K Probable disease-associated variant found in patients with undefined congenital myopathy. 1 PublicationCorresponds to variant dbSNP:rs1553248515EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054792 | 1 – 127 | Missing in isoform 7. CuratedAdd BLAST | 127 | |
Alternative sequenceiVSP_006604 | 1 – 81 | MMEAI…KKAAD → MAGITTIEAVKRKIQVLQQQ ADDAEERAERLQREVEGERR AREQ in isoform 2, isoform 3 and isoform 6. 2 PublicationsAdd BLAST | 81 | |
Alternative sequenceiVSP_047302 | 1 – 2 | MM → MAGITTI in isoform 4 and isoform 5. Curated | 2 | |
Alternative sequenceiVSP_047303 | 5 – 21 | IKKKM…ENALD → VKRKIQVLQQQADDAEE in isoform 4 and isoform 5. CuratedAdd BLAST | 17 | |
Alternative sequenceiVSP_047304 | 25 – 81 | QAEAE…KKAAD → RLQREVEGERRAREQ in isoform 4 and isoform 5. CuratedAdd BLAST | 57 | |
Alternative sequenceiVSP_006605 | 190 – 212 | KCSEL…LEAQA → RCREMDEQIRLMDQNLKCLS AAE in isoform 2, isoform 3 and isoform 6. 2 PublicationsAdd BLAST | 23 | |
Alternative sequenceiVSP_006607 | 259 – 285 | DELYA…DMTSI → ERLYSQLERNRLLSNELKLT LHDLCD in isoform 3. CuratedAdd BLAST | 27 | |
Alternative sequenceiVSP_047305 | 259 – 260 | DE → ER in isoform 4. Curated | 2 | |
Alternative sequenceiVSP_006606 | 260 – 285 | ELYAQ…DMTSI → KLKCTKEEHLCTQRMLDQTL LDLNEM in isoform 2, isoform 5 and isoform 7. 2 PublicationsAdd BLAST | 26 | |
Alternative sequenceiVSP_047306 | 263 – 285 | AQKLK…DMTSI → SQLERNRLLSNELKLTLHDL CD in isoform 4. CuratedAdd BLAST | 23 |
Sequence databases
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6OTN | X-ray | 2.40 | A/B/C/D | 44-117 | [»] | |
SMRi | P06753 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113023, 190 interactors |
IntActi | P06753, 102 interactors |
MINTi | P06753 |
STRINGi | 9606.ENSP00000357516 |
Chemistry databases
ChEMBLi | CHEMBL3804747 |
DrugBanki | DB12695, Phenethyl Isothiocyanate |
PTM databases
iPTMneti | P06753 |
MetOSitei | P06753 |
PhosphoSitePlusi | P06753 |
SwissPalmi | P06753 |
Genetic variation databases
BioMutai | TPM3 |
DMDMi | 519668659 |
2D gel databases
DOSAC-COBS-2DPAGEi | P06753 |
SWISS-2DPAGEi | P06753 |
Proteomic databases
EPDi | P06753 |
jPOSTi | P06753 |
MassIVEi | P06753 |
MaxQBi | P06753 |
PaxDbi | P06753 |
PeptideAtlasi | P06753 |
PRIDEi | P06753 |
ProteomicsDBi | 51930 [P06753-1] 51931 [P06753-2] 51932 [P06753-3] 65387 65390 65392 65394 |
Protocols and materials databases
Antibodypediai | 1682, 223 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 7170 |
DisGeNETi | 7170 |
GeneCardsi | TPM3 |
GeneReviewsi | TPM3 |
HGNCi | HGNC:12012, TPM3 |
HPAi | ENSG00000143549, Tissue enhanced (skeletal muscle, tongue) |
MalaCardsi | TPM3 |
MIMi | 164970, gene 191030, gene 255310, phenotype 609284, phenotype |
neXtProti | NX_P06753 |
OpenTargetsi | ENSG00000143549 |
Orphaneti | 171881, Cap myopathy 171439, Childhood-onset nemaline myopathy 2020, Congenital fiber-type disproportion myopathy 476406, Congenital generalized hypercontractile muscle stiffness syndrome 178342, Inflammatory myofibroblastic tumor 171433, Intermediate nemaline myopathy |
PharmGKBi | PA36692 |
VEuPathDBi | HostDB:ENSG00000143549.19 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1003, Eukaryota |
GeneTreei | ENSGT01010000222381 |
HOGENOMi | CLU_055027_3_0_1 |
InParanoidi | P06753 |
OMAi | EKKAADX |
OrthoDBi | 1576041at2759 |
PhylomeDBi | P06753 |
TreeFami | TF351519 |
Enzyme and pathway databases
PathwayCommonsi | P06753 |
Reactomei | R-HSA-390522, Striated Muscle Contraction R-HSA-445355, Smooth Muscle Contraction |
SIGNORi | P06753 |
Miscellaneous databases
BioGRID-ORCSi | 7170, 4 hits in 872 CRISPR screens |
ChiTaRSi | TPM3, human |
GeneWikii | Tropomyosin_3 |
GenomeRNAii | 7170 |
Pharosi | P06753, Tbio |
PROi | PR:P06753 |
RNActi | P06753, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143549, Expressed in muscle of leg and 163 other tissues |
ExpressionAtlasi | P06753, baseline and differential |
Genevisiblei | P06753, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000533, Tropomyosin |
Pfami | View protein in Pfam PF00261, Tropomyosin, 1 hit |
PRINTSi | PR00194, TROPOMYOSIN |
PROSITEi | View protein in PROSITE PS00326, TROPOMYOSIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TPM3_HUMAN | |
Accessioni | P06753Primary (citable) accession number: P06753 Secondary accession number(s): D3DV71 Q9NQH8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | June 26, 2013 | |
Last modified: | February 10, 2021 | |
This is version 230 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families