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Entry version 221 (16 Oct 2019)
Sequence version 2 (26 Jun 2013)
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Protein

Tropomyosin alpha-3 chain

Gene

TPM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.By similarity

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Muscle protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390522 Striated Muscle Contraction
R-HSA-445355 Smooth Muscle Contraction

SIGNOR Signaling Network Open Resource

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SIGNORi
P06753

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tropomyosin alpha-3 chain
Alternative name(s):
Gamma-tropomyosin
Tropomyosin-3
Tropomyosin-5
Short name:
hTM5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TPM3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12012 TPM3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
164970 gene
191030 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P06753

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Nemaline myopathy 1 (NEM1)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of nemaline myopathy with autosomal dominant or recessive inheritance. Nemaline myopathies are disorders characterized by muscle weakness of varying onset and severity, and abnormal thread-like or rod-shaped structures in muscle fibers on histologic examination. Autosomal dominant NEM1 is characterized by a moderate phenotype with onset between birth and early second decade of life. Weakness is diffuse and symmetric with slow progression often with need for a wheelchair in adulthood. The autosomal recessive form has onset at birth with moderate to severe hypotonia and diffuse weakness. In the most severe cases, death can occur before 2 years. Less severe cases have delayed major motor milestones, and these patients may walk, but often need a wheelchair before 10 years.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0134609M → R in NEM1; decrease in the sensitivity of contraction to activating calcium. 2 PublicationsCorresponds to variant dbSNP:rs80358247EnsemblClinVar.1
Natural variantiVAR_07150088S → F in NEM1 and CAPM1. 1 Publication1
Natural variantiVAR_070067168R → C in CFTD, CAPM1 and NEM1; also found in patients with undefined congenital myopathy. 3 PublicationsCorresponds to variant dbSNP:rs121964854EnsemblClinVar.1
Natural variantiVAR_070069168R → H in NEM1, CAPM1 and CFTD; also found in patients with undefined congenital myopathy. 6 PublicationsCorresponds to variant dbSNP:rs121964852EnsemblClinVar.1
A chromosomal aberration involving TPM3 is found in papillary thyroid carcinomas (PTCs). A rearrangement with NTRK1 generates the TRK fusion transcript by fusing the amino end of isoform 2 of TPM3 to the 3'-end of NTRK1.1 Publication
Myopathy, congenital, with fiber-type disproportion (CFTD)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA genetically heterogeneous disorder in which there is relative hypotrophy of type 1 muscle fibers compared to type 2 fibers on skeletal muscle biopsy. However, these findings are not specific and can be found in many different myopathic and neuropathic conditions.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0714994A → V in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474711EnsemblClinVar.1
Natural variantiVAR_07150291R → P in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474713EnsemblClinVar.1
Natural variantiVAR_070066100L → M in CFTD. 1 PublicationCorresponds to variant dbSNP:rs121964853EnsemblClinVar.1
Natural variantiVAR_071503100L → V in CFTD. 1 Publication1
Natural variantiVAR_070067168R → C in CFTD, CAPM1 and NEM1; also found in patients with undefined congenital myopathy. 3 PublicationsCorresponds to variant dbSNP:rs121964854EnsemblClinVar.1
Natural variantiVAR_070068168R → G in CFTD. 1 PublicationCorresponds to variant dbSNP:rs121964854EnsemblClinVar.1
Natural variantiVAR_070069168R → H in NEM1, CAPM1 and CFTD; also found in patients with undefined congenital myopathy. 6 PublicationsCorresponds to variant dbSNP:rs121964852EnsemblClinVar.1
Natural variantiVAR_070070169K → E in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474715EnsemblClinVar.1
Natural variantiVAR_071506174E → A in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474716EnsemblClinVar.1
Natural variantiVAR_071507241E → K in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474717EnsemblClinVar.1
Natural variantiVAR_070071245R → G in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474718EnsemblClinVar.1
Cap myopathy 1 (CAPM1)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare congenital skeletal muscle disorder characterized by the presence of cap-like structures which are well demarcated and peripherally located under the sarcolemma and show abnormal accumulation of sarcomeric proteins. Clinical features are early onset of hypotonia and slowly progressive muscle weakness. Respiratory problems are common.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07150088S → F in NEM1 and CAPM1. 1 Publication1
Natural variantiVAR_071504149L → I in CAPM1. 1 Publication1
Natural variantiVAR_071505151E → A in CAPM1. 1 Publication1
Natural variantiVAR_071508245R → I in CAPM1. 1 PublicationCorresponds to variant dbSNP:rs797046047EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Nemaline myopathy, Proto-oncogene

Organism-specific databases

DisGeNET

More...
DisGeNETi
7170

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
TPM3

MalaCards human disease database

More...
MalaCardsi
TPM3
MIMi255310 phenotype
609284 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000143549

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
171881 Cap myopathy
171439 Childhood-onset nemaline myopathy
2020 Congenital fiber-type disproportion myopathy
476406 Congenital generalized hypercontractile muscle stiffness syndrome
178342 Inflammatory myofibroblastic tumor
171433 Intermediate nemaline myopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36692

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P06753

Chemistry databases

Drug and drug target database

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DrugBanki
DB12695 Phenethyl Isothiocyanate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TPM3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
519668659

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002056322 – 285Tropomyosin alpha-3 chainAdd BLAST284
Isoform 2 (identifier: P06753-2)
Initiator methionineiRemovedCombined sourcesCurated2 Publications
Isoform 3 (identifier: P06753-3)
Initiator methionineiRemovedCombined sources2 Publications

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylmethionineBy similarity1
Modified residuei54PhosphothreonineBy similarity1
Modified residuei62PhosphoserineBy similarity1
Modified residuei88PhosphoserineCombined sources1
Modified residuei109PhosphothreonineBy similarity1
Modified residuei207PhosphoserineBy similarity1
Modified residuei216PhosphoserineBy similarity1
Modified residuei253PhosphothreonineBy similarity1
Modified residuei262PhosphotyrosineBy similarity1
Modified residuei272PhosphoserineBy similarity1
Modified residuei283PhosphothreonineBy similarity1
Modified residuei284PhosphoserineBy similarity1
Isoform 2 (identifier: P06753-2)
Modified residuei2N-acetylalanineCombined sourcesCurated2 Publications1
Modified residuei177N6-acetyllysineCombined sourcesCurated2 Publications1
Modified residuei215N6-acetyllysineCombined sourcesCurated2 Publications1
Isoform 3 (identifier: P06753-3)
Modified residuei2N-acetylalanineCombined sources2 Publications1
Modified residuei177N6-acetyllysineCombined sources2 Publications1
Isoform 7 (identifier: P06753-7)
Modified residuei125N6-acetyllysineCombined sources1
Isoform 6 (identifier: P06753-6)
Modified residuei177N6-acetyllysineCombined sources1
Isoform 5 (identifier: P06753-5)
Modified residuei215N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P06753

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P06753

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P06753

MaxQB - The MaxQuant DataBase

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MaxQBi
P06753

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P06753

PeptideAtlas

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PeptideAtlasi
P06753

PRoteomics IDEntifications database

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PRIDEi
P06753

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
51930 [P06753-1]
51931 [P06753-2]
51932 [P06753-3]
65387
65390
65392
65394

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P06753

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
P06753

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P06753

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P06753

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P06753

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000143549 Expressed in 140 organ(s), highest expression level in muscle of leg

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P06753 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P06753 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA000261
HPA009066
HPA047089
HPA053624

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain (By similarity).

Interacts with TMOD1 (PubMed:8002995).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113023, 157 interactors

Protein interaction database and analysis system

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IntActi
P06753, 87 interactors

Molecular INTeraction database

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MINTi
P06753

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357516

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P06753

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1 – 285By similarityAdd BLAST285

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1003 Eukaryota
ENOG410XR5K LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182712

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231522

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P06753

KEGG Orthology (KO)

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KOi
K09290

Identification of Orthologs from Complete Genome Data

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OMAi
MDKREDY

Database of Orthologous Groups

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OrthoDBi
1575614at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P06753

TreeFam database of animal gene trees

More...
TreeFami
TF351519

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000533 Tropomyosin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00261 Tropomyosin, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00194 TROPOMYOSIN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00326 TROPOMYOSIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P06753-1) [UniParc]FASTAAdd to basket
Also known as: Skeletal muscle

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMEAIKKKMQ MLKLDKENAL DRAEQAEAEQ KQAEERSKQL EDELAAMQKK
60 70 80 90 100
LKGTEDELDK YSEALKDAQE KLELAEKKAA DAEAEVASLN RRIQLVEEEL
110 120 130 140 150
DRAQERLATA LQKLEEAEKA ADESERGMKV IENRALKDEE KMELQEIQLK
160 170 180 190 200
EAKHIAEEAD RKYEEVARKL VIIEGDLERT EERAELAESK CSELEEELKN
210 220 230 240 250
VTNNLKSLEA QAEKYSQKED KYEEEIKILT DKLKEAETRA EFAERSVAKL
260 270 280
EKTIDDLEDE LYAQKLKYKA ISEELDHALN DMTSI
Length:285
Mass (Da):32,950
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i99EAD24C45460A14
GO
Isoform 2 (identifier: P06753-2) [UniParc]FASTAAdd to basket
Also known as: Cytoskeletal, TM30nm

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MMEAIKKKMQ...LELAEKKAAD → MAGITTIEAV...VEGERRAREQ
     190-212: KCSELEEELKNVTNNLKSLEAQA → RCREMDEQIRLMDQNLKCLSAAE
     260-285: ELYAQKLKYKAISEELDHALNDMTSI → KLKCTKEEHLCTQRMLDQTLLDLNEM

Note: Peptides 2-27, 41-55, 132-153, 163-169, 216-225 and 237-248 have been identified and sequenced by MS.Combined sourcesCurated2 Publications PubMed:16201836 (ABC40673) sequence corresponds to a TPM3 retrocopy (rcTPM3) on chromosome 16 that is generated by retroposition of reversed transcribed mRNA back to the genome. rcTPM3 functionality is uncertain. It has been detected by MS in primary breast cancer tissues.Combined sourcesCurated2 Publications
Show »
Length:248
Mass (Da):29,033
Checksum:i5C049312A337BC19
GO
Isoform 3 (identifier: P06753-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MMEAIKKKMQ...LELAEKKAAD → MAGITTIEAV...VEGERRAREQ
     190-212: KCSELEEELKNVTNNLKSLEAQA → RCREMDEQIRLMDQNLKCLSAAE
     259-285: DELYAQKLKYKAISEELDHALNDMTSI → ERLYSQLERNRLLSNELKLTLHDLCD

Note: Peptides 2-27, 41-55, 132-153 and 163-169 have been identified and sequenced by MS.Combined sources2 Publications
Show »
Length:247
Mass (Da):28,955
Checksum:i4929E6D4591374D3
GO
Isoform 4 (identifier: P06753-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MM → MAGITTI
     5-21: IKKKMQMLKLDKENALD → VKRKIQVLQQQADDAEE
     25-81: QAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAAD → RLQREVEGERRAREQ
     259-260: DE → ER
     263-285: AQKLKYKAISEELDHALNDMTSI → SQLERNRLLSNELKLTLHDLCD

Note: Gene prediction based on EST data.
Show »
Length:247
Mass (Da):28,793
Checksum:i239796CBE73C98AE
GO
Isoform 5 (identifier: P06753-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MM → MAGITTI
     5-21: IKKKMQMLKLDKENALD → VKRKIQVLQQQADDAEE
     25-81: QAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAAD → RLQREVEGERRAREQ
     260-285: ELYAQKLKYKAISEELDHALNDMTSI → KLKCTKEEHLCTQRMLDQTLLDLNEM

Note: Gene prediction based on EST data.Combined sources
Show »
Length:248
Mass (Da):28,870
Checksum:i179E2D62BC8993F5
GO
Isoform 6 (identifier: P06753-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MMEAIKKKMQ...LELAEKKAAD → MAGITTIEAV...VEGERRAREQ
     190-212: KCSELEEELKNVTNNLKSLEAQA → RCREMDEQIRLMDQNLKCLSAAE

Note: No experimental confirmation available.Combined sources
Show »
Length:248
Mass (Da):28,922
Checksum:i5427F068894BF936
GO
Isoform 7 (identifier: P06753-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.
     260-285: ELYAQKLKYKAISEELDHALNDMTSI → KLKCTKEEHLCTQRMLDQTLLDLNEM

Note: No experimental confirmation available. Gene prediction based on EST data.Combined sources
Show »
Length:158
Mass (Da):18,603
Checksum:iD3F876D8EFC7265F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KN67J3KN67_HUMAN
Tropomyosin alpha-3 chain
TPM3
285Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5VU61Q5VU61_HUMAN
Tropomyosin alpha-3 chain
TPM3
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R2Y2Q3A0A2R2Y2Q3_HUMAN
Tropomyosin 3 nu
TPM3 TPM3nu
285Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0P6A0A494C0P6_HUMAN
Tropomyosin alpha-3 chain
TPM3
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWU8A0A087WWU8_HUMAN
Tropomyosin alpha-3 chain
TPM3
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C034A0A494C034_HUMAN
Tropomyosin alpha-3 chain
TPM3
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0G0A0A494C0G0_HUMAN
Tropomyosin alpha-3 chain
TPM3
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R904D6R904_HUMAN
Tropomyosin alpha-3 chain
TPM3
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGJ6D6RGJ6_HUMAN
Tropomyosin alpha-3 chain
TPM3
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti150K → E in CAA27243 (PubMed:12574106).Curated1
Isoform 2 (identifier: P06753-2)
Sequence conflicti33R → Q in ABC40673 (PubMed:16201836).Combined sourcesCurated2 Publications1
Sequence conflicti43E → K in ABC40673 (PubMed:16201836).Combined sourcesCurated2 Publications1
Sequence conflicti66A → P in ABC40673 (PubMed:16201836).Combined sourcesCurated2 Publications1
Sequence conflicti85D → G in ABC40673 (PubMed:16201836).Combined sourcesCurated2 Publications1
Sequence conflicti110I → L in ABC40673 (PubMed:16201836).Combined sourcesCurated2 Publications1
Sequence conflicti135I → T in ABC40673 (PubMed:16201836).Combined sourcesCurated2 Publications1
Sequence conflicti150A → T in ABC40673 (PubMed:16201836).Combined sourcesCurated2 Publications1
Sequence conflicti192L → F in ABC40673 (PubMed:16201836).Combined sourcesCurated2 Publications1
Sequence conflicti196L → P in ABC40673 (PubMed:16201836).Combined sourcesCurated2 Publications1
Sequence conflicti202R → C in ABC40673 (PubMed:16201836).Combined sourcesCurated2 Publications1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0714994A → V in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474711EnsemblClinVar.1
Natural variantiVAR_0134609M → R in NEM1; decrease in the sensitivity of contraction to activating calcium. 2 PublicationsCorresponds to variant dbSNP:rs80358247EnsemblClinVar.1
Natural variantiVAR_07150088S → F in NEM1 and CAPM1. 1 Publication1
Natural variantiVAR_07150191R → C Probable disease-associated mutation found in patients with undefined congenital myopathy. 1 Publication1
Natural variantiVAR_07150291R → P in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474713EnsemblClinVar.1
Natural variantiVAR_070066100L → M in CFTD. 1 PublicationCorresponds to variant dbSNP:rs121964853EnsemblClinVar.1
Natural variantiVAR_071503100L → V in CFTD. 1 Publication1
Natural variantiVAR_071504149L → I in CAPM1. 1 Publication1
Natural variantiVAR_071505151E → A in CAPM1. 1 Publication1
Natural variantiVAR_070067168R → C in CFTD, CAPM1 and NEM1; also found in patients with undefined congenital myopathy. 3 PublicationsCorresponds to variant dbSNP:rs121964854EnsemblClinVar.1
Natural variantiVAR_070068168R → G in CFTD. 1 PublicationCorresponds to variant dbSNP:rs121964854EnsemblClinVar.1
Natural variantiVAR_070069168R → H in NEM1, CAPM1 and CFTD; also found in patients with undefined congenital myopathy. 6 PublicationsCorresponds to variant dbSNP:rs121964852EnsemblClinVar.1
Natural variantiVAR_070070169K → E in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474715EnsemblClinVar.1
Natural variantiVAR_071506174E → A in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474716EnsemblClinVar.1
Natural variantiVAR_071507241E → K in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474717EnsemblClinVar.1
Natural variantiVAR_070071245R → G in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474718EnsemblClinVar.1
Natural variantiVAR_071508245R → I in CAPM1. 1 PublicationCorresponds to variant dbSNP:rs797046047EnsemblClinVar.1
Natural variantiVAR_071509253T → K Probable disease-associated mutation found in patients with undefined congenital myopathy. 1 PublicationCorresponds to variant dbSNP:rs1553248515EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0547921 – 127Missing in isoform 7. CuratedAdd BLAST127
Alternative sequenceiVSP_0066041 – 81MMEAI…KKAAD → MAGITTIEAVKRKIQVLQQQ ADDAEERAERLQREVEGERR AREQ in isoform 2, isoform 3 and isoform 6. 2 PublicationsAdd BLAST81
Alternative sequenceiVSP_0473021 – 2MM → MAGITTI in isoform 4 and isoform 5. Curated2
Alternative sequenceiVSP_0473035 – 21IKKKM…ENALD → VKRKIQVLQQQADDAEE in isoform 4 and isoform 5. CuratedAdd BLAST17
Alternative sequenceiVSP_04730425 – 81QAEAE…KKAAD → RLQREVEGERRAREQ in isoform 4 and isoform 5. CuratedAdd BLAST57
Alternative sequenceiVSP_006605190 – 212KCSEL…LEAQA → RCREMDEQIRLMDQNLKCLS AAE in isoform 2, isoform 3 and isoform 6. 2 PublicationsAdd BLAST23
Alternative sequenceiVSP_006607259 – 285DELYA…DMTSI → ERLYSQLERNRLLSNELKLT LHDLCD in isoform 3. CuratedAdd BLAST27
Alternative sequenceiVSP_047305259 – 260DE → ER in isoform 4. Curated2
Alternative sequenceiVSP_006606260 – 285ELYAQ…DMTSI → KLKCTKEEHLCTQRMLDQTL LDLNEM in isoform 2, isoform 5 and isoform 7. 2 PublicationsAdd BLAST26
Alternative sequenceiVSP_047306263 – 285AQKLK…DMTSI → SQLERNRLLSNELKLTLHDL CD in isoform 4. CuratedAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X04201 mRNA Translation: CAA27798.1
AY004867 mRNA Translation: AAF87083.1
X04588 mRNA Translation: CAB37185.1
AL590431 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53229.1
CH471121 Genomic DNA Translation: EAW53230.1
CH471121 Genomic DNA Translation: EAW53231.1
CH471121 Genomic DNA Translation: EAW53235.1
BC000771 mRNA Translation: AAH00771.1
BC008407 mRNA Translation: AAH08407.1
BC008425 mRNA Translation: AAH08425.1
BC015403 mRNA Translation: AAH15403.1
BC072428 mRNA Translation: AAH72428.1
DQ120714 Genomic DNA Translation: ABC40673.1
X03541 mRNA Translation: CAA27243.1 Different termination.
AF474157 mRNA Translation: AAL84570.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1060.1 [P06753-2]
CCDS41400.1 [P06753-5]
CCDS41401.1 [P06753-4]
CCDS41402.1 [P06753-3]
CCDS41403.1 [P06753-1]
CCDS60274.1 [P06753-7]
CCDS60275.1 [P06753-6]

Protein sequence database of the Protein Information Resource

More...
PIRi
A25530
S06210 A24199

NCBI Reference Sequences

More...
RefSeqi
NP_001036816.1, NM_001043351.1 [P06753-5]
NP_001036817.1, NM_001043352.1 [P06753-3]
NP_001036818.1, NM_001043353.1 [P06753-4]
NP_001265118.1, NM_001278189.1 [P06753-6]
NP_001265120.1, NM_001278191.1 [P06753-7]
NP_689476.2, NM_152263.3 [P06753-1]
NP_705935.1, NM_153649.3 [P06753-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000302206; ENSP00000307712; ENSG00000143549 [P06753-7]
ENST00000323144; ENSP00000357518; ENSG00000143549 [P06753-4]
ENST00000328159; ENSP00000357520; ENSG00000143549 [P06753-6]
ENST00000330188; ENSP00000339035; ENSG00000143549 [P06753-5]
ENST00000341485; ENSP00000341653; ENSG00000143549 [P06753-4]
ENST00000368531; ENSP00000357517; ENSG00000143549 [P06753-3]
ENST00000368533; ENSP00000357521; ENSG00000143549 [P06753-2]
ENST00000651641; ENSP00000498577; ENSG00000143549 [P06753-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7170

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7170

UCSC genome browser

More...
UCSCi
uc001fdy.2 human [P06753-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04201 mRNA Translation: CAA27798.1
AY004867 mRNA Translation: AAF87083.1
X04588 mRNA Translation: CAB37185.1
AL590431 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53229.1
CH471121 Genomic DNA Translation: EAW53230.1
CH471121 Genomic DNA Translation: EAW53231.1
CH471121 Genomic DNA Translation: EAW53235.1
BC000771 mRNA Translation: AAH00771.1
BC008407 mRNA Translation: AAH08407.1
BC008425 mRNA Translation: AAH08425.1
BC015403 mRNA Translation: AAH15403.1
BC072428 mRNA Translation: AAH72428.1
DQ120714 Genomic DNA Translation: ABC40673.1
X03541 mRNA Translation: CAA27243.1 Different termination.
AF474157 mRNA Translation: AAL84570.1
CCDSiCCDS1060.1 [P06753-2]
CCDS41400.1 [P06753-5]
CCDS41401.1 [P06753-4]
CCDS41402.1 [P06753-3]
CCDS41403.1 [P06753-1]
CCDS60274.1 [P06753-7]
CCDS60275.1 [P06753-6]
PIRiA25530
S06210 A24199
RefSeqiNP_001036816.1, NM_001043351.1 [P06753-5]
NP_001036817.1, NM_001043352.1 [P06753-3]
NP_001036818.1, NM_001043353.1 [P06753-4]
NP_001265118.1, NM_001278189.1 [P06753-6]
NP_001265120.1, NM_001278191.1 [P06753-7]
NP_689476.2, NM_152263.3 [P06753-1]
NP_705935.1, NM_153649.3 [P06753-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6OTNX-ray2.40A/B/C/D44-117[»]
SMRiP06753
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi113023, 157 interactors
IntActiP06753, 87 interactors
MINTiP06753
STRINGi9606.ENSP00000357516

Chemistry databases

DrugBankiDB12695 Phenethyl Isothiocyanate

PTM databases

iPTMnetiP06753
PhosphoSitePlusiP06753
SwissPalmiP06753

Polymorphism and mutation databases

BioMutaiTPM3
DMDMi519668659

2D gel databases

DOSAC-COBS-2DPAGEiP06753
SWISS-2DPAGEiP06753

Proteomic databases

EPDiP06753
jPOSTiP06753
MassIVEiP06753
MaxQBiP06753
PaxDbiP06753
PeptideAtlasiP06753
PRIDEiP06753
ProteomicsDBi51930 [P06753-1]
51931 [P06753-2]
51932 [P06753-3]
65387
65390
65392
65394

Genome annotation databases

EnsembliENST00000302206; ENSP00000307712; ENSG00000143549 [P06753-7]
ENST00000323144; ENSP00000357518; ENSG00000143549 [P06753-4]
ENST00000328159; ENSP00000357520; ENSG00000143549 [P06753-6]
ENST00000330188; ENSP00000339035; ENSG00000143549 [P06753-5]
ENST00000341485; ENSP00000341653; ENSG00000143549 [P06753-4]
ENST00000368531; ENSP00000357517; ENSG00000143549 [P06753-3]
ENST00000368533; ENSP00000357521; ENSG00000143549 [P06753-2]
ENST00000651641; ENSP00000498577; ENSG00000143549 [P06753-1]
GeneIDi7170
KEGGihsa:7170
UCSCiuc001fdy.2 human [P06753-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7170
DisGeNETi7170

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TPM3
GeneReviewsiTPM3
HGNCiHGNC:12012 TPM3
HPAiHPA000261
HPA009066
HPA047089
HPA053624
MalaCardsiTPM3
MIMi164970 gene
191030 gene
255310 phenotype
609284 phenotype
neXtProtiNX_P06753
OpenTargetsiENSG00000143549
Orphaneti171881 Cap myopathy
171439 Childhood-onset nemaline myopathy
2020 Congenital fiber-type disproportion myopathy
476406 Congenital generalized hypercontractile muscle stiffness syndrome
178342 Inflammatory myofibroblastic tumor
171433 Intermediate nemaline myopathy
PharmGKBiPA36692

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1003 Eukaryota
ENOG410XR5K LUCA
GeneTreeiENSGT00950000182712
HOGENOMiHOG000231522
InParanoidiP06753
KOiK09290
OMAiMDKREDY
OrthoDBi1575614at2759
PhylomeDBiP06753
TreeFamiTF351519

Enzyme and pathway databases

ReactomeiR-HSA-390522 Striated Muscle Contraction
R-HSA-445355 Smooth Muscle Contraction
SIGNORiP06753

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TPM3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Tropomyosin_3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7170
PharosiP06753

Protein Ontology

More...
PROi
PR:P06753

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143549 Expressed in 140 organ(s), highest expression level in muscle of leg
ExpressionAtlasiP06753 baseline and differential
GenevisibleiP06753 HS

Family and domain databases

InterProiView protein in InterPro
IPR000533 Tropomyosin
PfamiView protein in Pfam
PF00261 Tropomyosin, 1 hit
PRINTSiPR00194 TROPOMYOSIN
PROSITEiView protein in PROSITE
PS00326 TROPOMYOSIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPM3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06753
Secondary accession number(s): D3DV71
, P12324, Q2QD06, Q5VU58, Q5VU63, Q5VU66, Q5VU71, Q5VU72, Q8TCG3, Q969Q2, Q9NQH8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: June 26, 2013
Last modified: October 16, 2019
This is version 221 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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