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UniProtKB - P06753 (TPM3_HUMAN)

Entry version 228 (07 Oct 2020)
Sequence version 2 (26 Jun 2013)
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Protein

Tropomyosin alpha-3 chain

Gene

TPM3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.By similarity

Caution

It is uncertain whether Met-1 or Met-2 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Muscle protein

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P06753

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-390522, Striated Muscle Contraction
R-HSA-445355, Smooth Muscle Contraction

SIGNOR Signaling Network Open Resource

More...SIGNORi		P06753

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tropomyosin alpha-3 chain
Alternative name(s):
Gamma-tropomyosin
Tropomyosin-3
Tropomyosin-5
Short name:
hTM5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TPM3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000143549.19

Human Gene Nomenclature Database

More...HGNCi		HGNC:12012, TPM3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		164970, gene
191030, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P06753

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Nemaline myopathy 1 (NEM1)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of nemaline myopathy with autosomal dominant or recessive inheritance. Nemaline myopathies are disorders characterized by muscle weakness of varying onset and severity, and abnormal thread-like or rod-shaped structures in muscle fibers on histologic examination. Autosomal dominant NEM1 is characterized by a moderate phenotype with onset between birth and early second decade of life. Weakness is diffuse and symmetric with slow progression often with need for a wheelchair in adulthood. The autosomal recessive form has onset at birth with moderate to severe hypotonia and diffuse weakness. In the most severe cases, death can occur before 2 years. Less severe cases have delayed major motor milestones, and these patients may walk, but often need a wheelchair before 10 years.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0134609M → R in NEM1; decrease in the sensitivity of contraction to activating calcium. 2 PublicationsCorresponds to variant dbSNP:rs80358247EnsemblClinVar.1
Natural variantiVAR_07150088S → F in NEM1 and CAPM1. 1 Publication1
Natural variantiVAR_070067168R → C in CFTD, CAPM1 and NEM1; also found in patients with undefined congenital myopathy. 3 PublicationsCorresponds to variant dbSNP:rs121964854EnsemblClinVar.1
Natural variantiVAR_070069168R → H in NEM1, CAPM1 and CFTD; also found in patients with undefined congenital myopathy. 6 PublicationsCorresponds to variant dbSNP:rs121964852EnsemblClinVar.1
A chromosomal aberration involving TPM3 is found in papillary thyroid carcinomas (PTCs). A rearrangement with NTRK1 generates the TRK fusion transcript by fusing the amino end of isoform 2 of TPM3 to the 3'-end of NTRK1.1 Publication
Myopathy, congenital, with fiber-type disproportion (CFTD)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA genetically heterogeneous disorder in which there is relative hypotrophy of type 1 muscle fibers compared to type 2 fibers on skeletal muscle biopsy. However, these findings are not specific and can be found in many different myopathic and neuropathic conditions.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0714994A → V in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474711EnsemblClinVar.1
Natural variantiVAR_07150291R → P in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474713EnsemblClinVar.1
Natural variantiVAR_070066100L → M in CFTD. 1 PublicationCorresponds to variant dbSNP:rs121964853EnsemblClinVar.1
Natural variantiVAR_071503100L → V in CFTD. 1 PublicationCorresponds to variant dbSNP:rs121964853EnsemblClinVar.1
Natural variantiVAR_070067168R → C in CFTD, CAPM1 and NEM1; also found in patients with undefined congenital myopathy. 3 PublicationsCorresponds to variant dbSNP:rs121964854EnsemblClinVar.1
Natural variantiVAR_070068168R → G in CFTD. 1 PublicationCorresponds to variant dbSNP:rs121964854EnsemblClinVar.1
Natural variantiVAR_070069168R → H in NEM1, CAPM1 and CFTD; also found in patients with undefined congenital myopathy. 6 PublicationsCorresponds to variant dbSNP:rs121964852EnsemblClinVar.1
Natural variantiVAR_070070169K → E in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474715EnsemblClinVar.1
Natural variantiVAR_071506174E → A in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474716EnsemblClinVar.1
Natural variantiVAR_071507241E → K in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474717EnsemblClinVar.1
Natural variantiVAR_070071245R → G in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474718EnsemblClinVar.1
Cap myopathy 1 (CAPM1)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare congenital skeletal muscle disorder characterized by the presence of cap-like structures which are well demarcated and peripherally located under the sarcolemma and show abnormal accumulation of sarcomeric proteins. Clinical features are early onset of hypotonia and slowly progressive muscle weakness. Respiratory problems are common.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07150088S → F in NEM1 and CAPM1. 1 Publication1
Natural variantiVAR_071504149L → I in CAPM1. 1 Publication1
Natural variantiVAR_071505151E → A in CAPM1. 1 Publication1
Natural variantiVAR_071508245R → I in CAPM1. 1 PublicationCorresponds to variant dbSNP:rs797046047EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Nemaline myopathy, Proto-oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		7170

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		TPM3

MalaCards human disease database

More...MalaCardsi		TPM3
MIMi255310, phenotype
609284, phenotype

Open Targets

More...OpenTargetsi		ENSG00000143549

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		171881, Cap myopathy
171439, Childhood-onset nemaline myopathy
2020, Congenital fiber-type disproportion myopathy
476406, Congenital generalized hypercontractile muscle stiffness syndrome
178342, Inflammatory myofibroblastic tumor
171433, Intermediate nemaline myopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36692

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P06753, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3804747

Drug and drug target database

More...DrugBanki		DB12695, Phenethyl Isothiocyanate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TPM3

Domain mapping of disease mutations (DMDM)

More...DMDMi		519668659

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002056322 – 285Tropomyosin alpha-3 chainAdd BLAST284
Isoform 2 (identifier: P06753-2)
Initiator methionineiRemovedCurated
Isoform 3 (identifier: P06753-3)
Initiator methionineiRemovedCurated

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylmethionineBy similarity1
Modified residuei54PhosphothreonineBy similarity1
Modified residuei62PhosphoserineBy similarity1
Modified residuei88PhosphoserineCombined sources1
Modified residuei109PhosphothreonineBy similarity1
Modified residuei207PhosphoserineBy similarity1
Modified residuei216PhosphoserineBy similarity1
Modified residuei253PhosphothreonineBy similarity1
Modified residuei262PhosphotyrosineBy similarity1
Modified residuei272PhosphoserineBy similarity1
Modified residuei283PhosphothreonineBy similarity1
Modified residuei284PhosphoserineBy similarity1
Isoform 2 (identifier: P06753-2)
Modified residuei2N-acetylalanineCurated1
Modified residuei177N6-acetyllysineCombined sources1
Modified residuei215N6-acetyllysineCombined sources1
Isoform 3 (identifier: P06753-3)
Modified residuei2N-acetylalanineCurated1
Modified residuei177N6-acetyllysineCombined sources1
Isoform 7 (identifier: P06753-7)
Modified residuei125N6-acetyllysineCombined sources1
Isoform 6 (identifier: P06753-6)
Modified residuei177N6-acetyllysineCombined sources1
Isoform 5 (identifier: P06753-5)
Modified residuei215N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P06753

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P06753

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P06753

MaxQB - The MaxQuant DataBase

More...MaxQBi		P06753

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P06753

PeptideAtlas

More...PeptideAtlasi		P06753

PRoteomics IDEntifications database

More...PRIDEi		P06753

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51930 [P06753-1]
51931 [P06753-2]
51932 [P06753-3]
65387
65390
65392
65394

2D gel databases

DOSAC-COBS 2D-PAGE database

More...DOSAC-COBS-2DPAGEi		P06753

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P06753

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P06753

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P06753

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P06753

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P06753

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000143549, Expressed in muscle of leg and 163 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P06753, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P06753, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000143549, Tissue enhanced (skeletal muscle, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain (By similarity).

Interacts with TMOD1 (PubMed:8002995).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		113023, 182 interactors

Protein interaction database and analysis system

More...IntActi		P06753, 96 interactors

Molecular INTeraction database

More...MINTi		P06753

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000357516

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P06753, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1285
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P06753

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1 – 285By similarityAdd BLAST285

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tropomyosin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1003, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01000000214597

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_055027_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P06753

KEGG Orthology (KO)

More...KOi		K09290

Identification of Orthologs from Complete Genome Data

More...OMAi		EKKAADX

Database of Orthologous Groups

More...OrthoDBi		1576041at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P06753

TreeFam database of animal gene trees

More...TreeFami		TF351519

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000533, Tropomyosin

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00261, Tropomyosin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00194, TROPOMYOSIN

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00326, TROPOMYOSIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P06753-1) [UniParc]FASTAAdd to basket
Also known as: Skeletal muscle

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMEAIKKKMQ MLKLDKENAL DRAEQAEAEQ KQAEERSKQL EDELAAMQKK 
        60         70         80         90        100
LKGTEDELDK YSEALKDAQE KLELAEKKAA DAEAEVASLN RRIQLVEEEL 
       110        120        130        140        150
DRAQERLATA LQKLEEAEKA ADESERGMKV IENRALKDEE KMELQEIQLK 
       160        170        180        190        200
EAKHIAEEAD RKYEEVARKL VIIEGDLERT EERAELAESK CSELEEELKN 
       210        220        230        240        250
VTNNLKSLEA QAEKYSQKED KYEEEIKILT DKLKEAETRA EFAERSVAKL 
       260        270        280 
EKTIDDLEDE LYAQKLKYKA ISEELDHALN DMTSI
Length:285
Mass (Da):32,950
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i99EAD24C45460A14
GO
Isoform 2 (identifier: P06753-2) [UniParc]FASTAAdd to basket
Also known as: Cytoskeletal, TM30nm

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MMEAIKKKMQ...LELAEKKAAD → MAGITTIEAV...VEGERRAREQ
     190-212: KCSELEEELKNVTNNLKSLEAQA → RCREMDEQIRLMDQNLKCLSAAE
     260-285: ELYAQKLKYKAISEELDHALNDMTSI → KLKCTKEEHLCTQRMLDQTLLDLNEM

Note: Peptides 2-27, 41-55, 132-153, 163-169, 216-225 and 237-248 have been identified and sequenced by MS. PubMed:16201836 (ABC40673) sequence corresponds to a TPM3 retrocopy (rcTPM3) on chromosome 16 that is generated by retroposition of reversed transcribed mRNA back to the genome. rcTPM3 functionality is uncertain. It has been detected by MS in primary breast cancer tissues.Curated2 Publications
Show »
Length:248
Mass (Da):29,033
Checksum:i5C049312A337BC19
GO
Isoform 3 (identifier: P06753-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MMEAIKKKMQ...LELAEKKAAD → MAGITTIEAV...VEGERRAREQ
     190-212: KCSELEEELKNVTNNLKSLEAQA → RCREMDEQIRLMDQNLKCLSAAE
     259-285: DELYAQKLKYKAISEELDHALNDMTSI → ERLYSQLERNRLLSNELKLTLHDLCD

Note: Peptides 2-27, 41-55, 132-153 and 163-169 have been identified and sequenced by MS.Curated2 Publications
Show »
Length:247
Mass (Da):28,955
Checksum:i4929E6D4591374D3
GO
Isoform 4 (identifier: P06753-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MM → MAGITTI
     5-21: IKKKMQMLKLDKENALD → VKRKIQVLQQQADDAEE
     25-81: QAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAAD → RLQREVEGERRAREQ
     259-260: DE → ER
     263-285: AQKLKYKAISEELDHALNDMTSI → SQLERNRLLSNELKLTLHDLCD

Show »
Length:247
Mass (Da):28,793
Checksum:i239796CBE73C98AE
GO
Isoform 5 (identifier: P06753-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2: MM → MAGITTI
     5-21: IKKKMQMLKLDKENALD → VKRKIQVLQQQADDAEE
     25-81: QAEAEQKQAEERSKQLEDELAAMQKKLKGTEDELDKYSEALKDAQEKLELAEKKAAD → RLQREVEGERRAREQ
     260-285: ELYAQKLKYKAISEELDHALNDMTSI → KLKCTKEEHLCTQRMLDQTLLDLNEM

Show »
Length:248
Mass (Da):28,870
Checksum:i179E2D62BC8993F5
GO
Isoform 6 (identifier: P06753-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MMEAIKKKMQ...LELAEKKAAD → MAGITTIEAV...VEGERRAREQ
     190-212: KCSELEEELKNVTNNLKSLEAQA → RCREMDEQIRLMDQNLKCLSAAE

Show »
Length:248
Mass (Da):28,922
Checksum:i5427F068894BF936
GO
Isoform 7 (identifier: P06753-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.
     260-285: ELYAQKLKYKAISEELDHALNDMTSI → KLKCTKEEHLCTQRMLDQTLLDLNEM

Show »
Length:158
Mass (Da):18,603
Checksum:iD3F876D8EFC7265F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KN67J3KN67_HUMAN
Tropomyosin alpha-3 chain
TPM3
285Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R2Y2Q3A0A2R2Y2Q3_HUMAN
Tropomyosin 3 nu
TPM3 TPM3nu
285Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0P6A0A494C0P6_HUMAN
Tropomyosin alpha-3 chain
TPM3
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5VU61Q5VU61_HUMAN
Tropomyosin alpha-3 chain
TPM3
49Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WWU8A0A087WWU8_HUMAN
Tropomyosin alpha-3 chain
TPM3
227Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C034A0A494C034_HUMAN
Tropomyosin alpha-3 chain
TPM3
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0G0A0A494C0G0_HUMAN
Tropomyosin alpha-3 chain
TPM3
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R904D6R904_HUMAN
Tropomyosin alpha-3 chain
TPM3
95Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGJ6D6RGJ6_HUMAN
Tropomyosin alpha-3 chain
TPM3
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti150K → E in CAA27243 (PubMed:12574106).Curated1
Isoform 2 (identifier: P06753-2)
Sequence conflicti33R → Q in ABC40673 (PubMed:16201836).Curated1
Sequence conflicti43E → K in ABC40673 (PubMed:16201836).Curated1
Sequence conflicti66A → P in ABC40673 (PubMed:16201836).Curated1
Sequence conflicti85D → G in ABC40673 (PubMed:16201836).Curated1
Sequence conflicti110I → L in ABC40673 (PubMed:16201836).Curated1
Sequence conflicti135I → T in ABC40673 (PubMed:16201836).Curated1
Sequence conflicti150A → T in ABC40673 (PubMed:16201836).Curated1
Sequence conflicti192L → F in ABC40673 (PubMed:16201836).Curated1
Sequence conflicti196L → P in ABC40673 (PubMed:16201836).Curated1
Sequence conflicti202R → C in ABC40673 (PubMed:16201836).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0714994A → V in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474711EnsemblClinVar.1
Natural variantiVAR_0134609M → R in NEM1; decrease in the sensitivity of contraction to activating calcium. 2 PublicationsCorresponds to variant dbSNP:rs80358247EnsemblClinVar.1
Natural variantiVAR_07150088S → F in NEM1 and CAPM1. 1 Publication1
Natural variantiVAR_07150191R → C Probable disease-associated variant found in patients with undefined congenital myopathy. 1 Publication1
Natural variantiVAR_07150291R → P in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474713EnsemblClinVar.1
Natural variantiVAR_070066100L → M in CFTD. 1 PublicationCorresponds to variant dbSNP:rs121964853EnsemblClinVar.1
Natural variantiVAR_071503100L → V in CFTD. 1 PublicationCorresponds to variant dbSNP:rs121964853EnsemblClinVar.1
Natural variantiVAR_071504149L → I in CAPM1. 1 Publication1
Natural variantiVAR_071505151E → A in CAPM1. 1 Publication1
Natural variantiVAR_070067168R → C in CFTD, CAPM1 and NEM1; also found in patients with undefined congenital myopathy. 3 PublicationsCorresponds to variant dbSNP:rs121964854EnsemblClinVar.1
Natural variantiVAR_070068168R → G in CFTD. 1 PublicationCorresponds to variant dbSNP:rs121964854EnsemblClinVar.1
Natural variantiVAR_070069168R → H in NEM1, CAPM1 and CFTD; also found in patients with undefined congenital myopathy. 6 PublicationsCorresponds to variant dbSNP:rs121964852EnsemblClinVar.1
Natural variantiVAR_070070169K → E in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474715EnsemblClinVar.1
Natural variantiVAR_071506174E → A in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474716EnsemblClinVar.1
Natural variantiVAR_071507241E → K in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474717EnsemblClinVar.1
Natural variantiVAR_070071245R → G in CFTD. 1 PublicationCorresponds to variant dbSNP:rs199474718EnsemblClinVar.1
Natural variantiVAR_071508245R → I in CAPM1. 1 PublicationCorresponds to variant dbSNP:rs797046047EnsemblClinVar.1
Natural variantiVAR_071509253T → K Probable disease-associated variant found in patients with undefined congenital myopathy. 1 PublicationCorresponds to variant dbSNP:rs1553248515EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0547921 – 127Missing in isoform 7. CuratedAdd BLAST127
Alternative sequenceiVSP_0066041 – 81MMEAI…KKAAD → MAGITTIEAVKRKIQVLQQQ ADDAEERAERLQREVEGERR AREQ in isoform 2, isoform 3 and isoform 6. 2 PublicationsAdd BLAST81
Alternative sequenceiVSP_0473021 – 2MM → MAGITTI in isoform 4 and isoform 5. Curated2
Alternative sequenceiVSP_0473035 – 21IKKKM…ENALD → VKRKIQVLQQQADDAEE in isoform 4 and isoform 5. CuratedAdd BLAST17
Alternative sequenceiVSP_04730425 – 81QAEAE…KKAAD → RLQREVEGERRAREQ in isoform 4 and isoform 5. CuratedAdd BLAST57
Alternative sequenceiVSP_006605190 – 212KCSEL…LEAQA → RCREMDEQIRLMDQNLKCLS AAE in isoform 2, isoform 3 and isoform 6. 2 PublicationsAdd BLAST23
Alternative sequenceiVSP_006607259 – 285DELYA…DMTSI → ERLYSQLERNRLLSNELKLT LHDLCD in isoform 3. CuratedAdd BLAST27
Alternative sequenceiVSP_047305259 – 260DE → ER in isoform 4. Curated2
Alternative sequenceiVSP_006606260 – 285ELYAQ…DMTSI → KLKCTKEEHLCTQRMLDQTL LDLNEM in isoform 2, isoform 5 and isoform 7. 2 PublicationsAdd BLAST26
Alternative sequenceiVSP_047306263 – 285AQKLK…DMTSI → SQLERNRLLSNELKLTLHDL CD in isoform 4. CuratedAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X04201 mRNA Translation: CAA27798.1
AY004867 mRNA Translation: AAF87083.1
X04588 mRNA Translation: CAB37185.1
AL590431 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53229.1
CH471121 Genomic DNA Translation: EAW53230.1
CH471121 Genomic DNA Translation: EAW53231.1
CH471121 Genomic DNA Translation: EAW53235.1
BC000771 mRNA Translation: AAH00771.1
BC008407 mRNA Translation: AAH08407.1
BC008425 mRNA Translation: AAH08425.1
BC015403 mRNA Translation: AAH15403.1
BC072428 mRNA Translation: AAH72428.1
DQ120714 Genomic DNA Translation: ABC40673.1
X03541 mRNA Translation: CAA27243.1 Different termination.
AF474157 mRNA Translation: AAL84570.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1060.1 [P06753-2]
CCDS41400.1 [P06753-5]
CCDS41401.1 [P06753-4]
CCDS41402.1 [P06753-3]
CCDS41403.1 [P06753-1]
CCDS60274.1 [P06753-7]
CCDS60275.1 [P06753-6]

Protein sequence database of the Protein Information Resource

More...PIRi		A25530
S06210, A24199

NCBI Reference Sequences

More...RefSeqi		NP_001036816.1, NM_001043351.1 [P06753-5]
NP_001036817.1, NM_001043352.1 [P06753-3]
NP_001036818.1, NM_001043353.1 [P06753-4]
NP_001265118.1, NM_001278189.1 [P06753-6]
NP_001265120.1, NM_001278191.1 [P06753-7]
NP_689476.2, NM_152263.3 [P06753-1]
NP_705935.1, NM_153649.3 [P06753-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000302206; ENSP00000307712; ENSG00000143549 [P06753-7]
ENST00000323144; ENSP00000357518; ENSG00000143549 [P06753-4]
ENST00000328159; ENSP00000357520; ENSG00000143549 [P06753-6]
ENST00000330188; ENSP00000339035; ENSG00000143549 [P06753-5]
ENST00000341485; ENSP00000341653; ENSG00000143549 [P06753-4]
ENST00000368531; ENSP00000357517; ENSG00000143549 [P06753-3]
ENST00000368533; ENSP00000357521; ENSG00000143549 [P06753-2]
ENST00000651641; ENSP00000498577; ENSG00000143549 [P06753-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		7170

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:7170

UCSC genome browser

More...UCSCi		uc001fdy.2, human [P06753-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04201 mRNA Translation: CAA27798.1
AY004867 mRNA Translation: AAF87083.1
X04588 mRNA Translation: CAB37185.1
AL590431 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53229.1
CH471121 Genomic DNA Translation: EAW53230.1
CH471121 Genomic DNA Translation: EAW53231.1
CH471121 Genomic DNA Translation: EAW53235.1
BC000771 mRNA Translation: AAH00771.1
BC008407 mRNA Translation: AAH08407.1
BC008425 mRNA Translation: AAH08425.1
BC015403 mRNA Translation: AAH15403.1
BC072428 mRNA Translation: AAH72428.1
DQ120714 Genomic DNA Translation: ABC40673.1
X03541 mRNA Translation: CAA27243.1 Different termination.
AF474157 mRNA Translation: AAL84570.1
CCDSiCCDS1060.1 [P06753-2]
CCDS41400.1 [P06753-5]
CCDS41401.1 [P06753-4]
CCDS41402.1 [P06753-3]
CCDS41403.1 [P06753-1]
CCDS60274.1 [P06753-7]
CCDS60275.1 [P06753-6]
PIRiA25530
S06210, A24199
RefSeqiNP_001036816.1, NM_001043351.1 [P06753-5]
NP_001036817.1, NM_001043352.1 [P06753-3]
NP_001036818.1, NM_001043353.1 [P06753-4]
NP_001265118.1, NM_001278189.1 [P06753-6]
NP_001265120.1, NM_001278191.1 [P06753-7]
NP_689476.2, NM_152263.3 [P06753-1]
NP_705935.1, NM_153649.3 [P06753-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6OTNX-ray2.40A/B/C/D44-117[»]
SMRiP06753
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi113023, 182 interactors
IntActiP06753, 96 interactors
MINTiP06753
STRINGi9606.ENSP00000357516

Chemistry databases

ChEMBLiCHEMBL3804747
DrugBankiDB12695, Phenethyl Isothiocyanate

PTM databases

iPTMnetiP06753
MetOSiteiP06753
PhosphoSitePlusiP06753
SwissPalmiP06753

Polymorphism and mutation databases

BioMutaiTPM3
DMDMi519668659

2D gel databases

DOSAC-COBS-2DPAGEiP06753
SWISS-2DPAGEiP06753

Proteomic databases

EPDiP06753
jPOSTiP06753
MassIVEiP06753
MaxQBiP06753
PaxDbiP06753
PeptideAtlasiP06753
PRIDEiP06753
ProteomicsDBi51930 [P06753-1]
51931 [P06753-2]
51932 [P06753-3]
65387
65390
65392
65394

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1682, 223 antibodies

Genome annotation databases

EnsembliENST00000302206; ENSP00000307712; ENSG00000143549 [P06753-7]
ENST00000323144; ENSP00000357518; ENSG00000143549 [P06753-4]
ENST00000328159; ENSP00000357520; ENSG00000143549 [P06753-6]
ENST00000330188; ENSP00000339035; ENSG00000143549 [P06753-5]
ENST00000341485; ENSP00000341653; ENSG00000143549 [P06753-4]
ENST00000368531; ENSP00000357517; ENSG00000143549 [P06753-3]
ENST00000368533; ENSP00000357521; ENSG00000143549 [P06753-2]
ENST00000651641; ENSP00000498577; ENSG00000143549 [P06753-1]
GeneIDi7170
KEGGihsa:7170
UCSCiuc001fdy.2, human [P06753-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7170
DisGeNETi7170
EuPathDBiHostDB:ENSG00000143549.19

GeneCards: human genes, protein and diseases

More...GeneCardsi		TPM3
GeneReviewsiTPM3
HGNCiHGNC:12012, TPM3
HPAiENSG00000143549, Tissue enhanced (skeletal muscle, tongue)
MalaCardsiTPM3
MIMi164970, gene
191030, gene
255310, phenotype
609284, phenotype
neXtProtiNX_P06753
OpenTargetsiENSG00000143549
Orphaneti171881, Cap myopathy
171439, Childhood-onset nemaline myopathy
2020, Congenital fiber-type disproportion myopathy
476406, Congenital generalized hypercontractile muscle stiffness syndrome
178342, Inflammatory myofibroblastic tumor
171433, Intermediate nemaline myopathy
PharmGKBiPA36692

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1003, Eukaryota
GeneTreeiENSGT01000000214597
HOGENOMiCLU_055027_3_0_1
InParanoidiP06753
KOiK09290
OMAiEKKAADX
OrthoDBi1576041at2759
PhylomeDBiP06753
TreeFamiTF351519

Enzyme and pathway databases

PathwayCommonsiP06753
ReactomeiR-HSA-390522, Striated Muscle Contraction
R-HSA-445355, Smooth Muscle Contraction
SIGNORiP06753

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		7170, 4 hits in 869 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TPM3, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Tropomyosin_3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		7170
PharosiP06753, Tbio

Protein Ontology

More...PROi		PR:P06753
RNActiP06753, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000143549, Expressed in muscle of leg and 163 other tissues
ExpressionAtlasiP06753, baseline and differential
GenevisibleiP06753, HS

Family and domain databases

InterProiView protein in InterPro
IPR000533, Tropomyosin
PfamiView protein in Pfam
PF00261, Tropomyosin, 1 hit
PRINTSiPR00194, TROPOMYOSIN
PROSITEiView protein in PROSITE
PS00326, TROPOMYOSIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPM3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06753
Secondary accession number(s): D3DV71
, P12324, Q2QD06, Q5VU58, Q5VU63, Q5VU66, Q5VU71, Q5VU72, Q8TCG3, Q969Q2, Q9NQH8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: June 26, 2013
Last modified: October 7, 2020
This is version 228 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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