UniProtKB - P06746 (DPOLB_HUMAN)
Protein
DNA polymerase beta
Gene
POLB
Organism
Homo sapiens (Human)
Status
Functioni
Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.4 Publications
Catalytic activityi
- EC:2.7.7.7
Cofactori
Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 72 | Schiff-base intermediate with DNA | 1 | |
Metal bindingi | 101 | Sodium; via carbonyl oxygen | 1 | |
Metal bindingi | 103 | Sodium; via carbonyl oxygen | 1 | |
Metal bindingi | 106 | Sodium; via carbonyl oxygen | 1 | |
Metal bindingi | 190 | Magnesium 1 | 1 | |
Metal bindingi | 190 | Magnesium 2 | 1 | |
Metal bindingi | 192 | Magnesium 1 | 1 | |
Metal bindingi | 192 | Magnesium 2 | 1 | |
Metal bindingi | 256 | Magnesium 2 | 1 |
GO - Molecular functioni
- damaged DNA binding Source: Ensembl
- DNA-directed DNA polymerase activity Source: UniProtKB
- enzyme binding Source: UniProtKB
- lyase activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- microtubule binding Source: MGI
GO - Biological processi
- aging Source: Ensembl
- base-excision repair Source: UniProtKB
- base-excision repair, base-free sugar-phosphate removal Source: Reactome
- base-excision repair, DNA ligation Source: Reactome
- base-excision repair, gap-filling Source: Reactome
- cellular response to DNA damage stimulus Source: UniProtKB
- DNA-dependent DNA replication Source: ProtInc
- DNA repair Source: ProtInc
- double-strand break repair via nonhomologous end joining Source: GO_Central
- homeostasis of number of cells Source: Ensembl
- immunoglobulin heavy chain V-D-J recombination Source: Ensembl
- inflammatory response Source: Ensembl
- intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
- in utero embryonic development Source: Ensembl
- lymph node development Source: Ensembl
- neuron apoptotic process Source: Ensembl
- protein deubiquitination Source: Reactome
- pyrimidine dimer repair Source: Ensembl
- response to ethanol Source: Ensembl
- response to gamma radiation Source: Ensembl
- response to hyperoxia Source: Ensembl
- salivary gland morphogenesis Source: Ensembl
- somatic hypermutation of immunoglobulin genes Source: Ensembl
- spleen development Source: Ensembl
Keywordsi
Molecular function | DNA-binding, DNA-directed DNA polymerase, Lyase, Nucleotidyltransferase, Transferase |
Biological process | DNA damage, DNA repair, DNA replication, DNA synthesis |
Ligand | Magnesium, Metal-binding, Sodium |
Enzyme and pathway databases
BRENDAi | 2.7.7.7, 2681 4.2.99.B1, 2681 |
PathwayCommonsi | P06746 |
Reactomei | R-HSA-110362, POLB-Dependent Long Patch Base Excision Repair R-HSA-110373, Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110381, Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-5649702, APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5651801, PCNA-Dependent Long Patch Base Excision Repair R-HSA-5689880, Ub-specific processing proteases R-HSA-73930, Abasic sugar-phosphate removal via the single-nucleotide replacement pathway |
SIGNORi | P06746 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:POLB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9174, POLB |
MIMi | 174760, gene |
neXtProti | NX_P06746 |
VEuPathDBi | HostDB:ENSG00000070501.11 |
Subcellular locationi
Cytoskeleton
- microtubule Source: MGI
- spindle microtubule Source: MGI
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- protein-containing complex Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 35 | K → Q or R: Reduces DNA lyase activity slightly. 1 Publication | 1 | |
Mutagenesisi | 39 | Y → Q: Abolishes DNA polymerase and DNA lyase activity. 1 Publication | 1 | |
Mutagenesisi | 41 | K → R: Abolishes ubiquitination; when associated with R-61 and R-81. 1 Publication | 1 | |
Mutagenesisi | 61 | K → R: Abolishes ubiquitination; when associated with R-41 and R-81. 1 Publication | 1 | |
Mutagenesisi | 68 | K → Q or R: Reduces DNA lyase activity slightly. 1 Publication | 1 | |
Mutagenesisi | 72 | K → Q or R: Abolishes DNA lyase activity. No effect on DNA polymerase activity. 1 Publication | 1 | |
Mutagenesisi | 81 | K → R: Abolishes ubiquitination; when associated with R-41 and R-61. 1 Publication | 1 | |
Mutagenesisi | 83 | R → K: Slight effect. Abolishes methylation by PRMT6 and impairs the polymerase activity; when associated with K-152. 1 Publication | 1 | |
Mutagenesisi | 84 | K → R: No effect. 1 Publication | 1 | |
Mutagenesisi | 152 | R → K: Slight effect. Abolishes methylation by PRMT6 and impairs the polymerase activity; when associated with K-83. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 5423 |
OpenTargetsi | ENSG00000070501 |
PharmGKBi | PA276 |
Miscellaneous databases
Pharosi | P06746, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2392 |
DrugBanki | DB07479, (1S)-1,2,3,4-TETRAHYDRO-BENZO[C]PHENANTHRENE-2,3,4-TRIOL DB00987, Cytarabine DB03222, dATP DB14490, Ferrous ascorbate DB14491, Ferrous fumarate DB14488, Ferrous gluconate DB14501, Ferrous glycine sulfate DB14489, Ferrous succinate DB01592, Iron |
DrugCentrali | P06746 |
Genetic variation databases
BioMutai | POLB |
DMDMi | 544186 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000218778 | 1 – 335 | DNA polymerase betaAdd BLAST | 335 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 41 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications | ||
Cross-linki | 61 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications | ||
Modified residuei | 72 | N6-acetyllysineBy similarity | 1 | |
Cross-linki | 81 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications | ||
Modified residuei | 83 | Omega-N-methylarginine; by PRMT61 Publication | 1 | |
Modified residuei | 152 | Omega-N-methylarginine; by PRMT61 Publication | 1 |
Post-translational modificationi
Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.1 Publication
Ubiquitinated at Lys-41, Lys-61 and Lys-81: monoubiquitinated by HUWE1/ARF-BP1. Monoubiquitinated protein is then the target of STUB1/CHIP, which catalyzes polyubiquitination from monoubiquitin, leading to degradation by the proteasome. USP47 mediates the deubiquitination of monoubiquitinated protein, preventing polyubiquitination by STUB1/CHIP and its subsequent degradation.2 Publications
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Ubl conjugationProteomic databases
EPDi | P06746 |
jPOSTi | P06746 |
MassIVEi | P06746 |
MaxQBi | P06746 |
PaxDbi | P06746 |
PeptideAtlasi | P06746 |
PRIDEi | P06746 |
ProteomicsDBi | 51926 |
PTM databases
iPTMneti | P06746 |
PhosphoSitePlusi | P06746 |
Expressioni
Gene expression databases
Bgeei | ENSG00000070501, Expressed in cerebellar hemisphere and 236 other tissues |
ExpressionAtlasi | P06746, baseline and differential |
Genevisiblei | P06746, HS |
Organism-specific databases
HPAi | ENSG00000070501, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Monomer.
Interacts with APEX1, HUWE1/ARF-BP1, STUB1/CHIP and USP47.
Interacts with FAM168A (PubMed:25260657).
7 PublicationsBinary interactionsi
Hide detailsP06746
With | #Exp. | IntAct |
---|---|---|
TAF1D [Q9H5J8] | 4 | EBI-713836,EBI-716128 |
TPP2 [P29144] | 8 | EBI-713836,EBI-1044672 |
WFS1 [O76024] | 3 | EBI-713836,EBI-720609 |
XRCC1 [P18887] | 3 | EBI-713836,EBI-947466 |
GO - Molecular functioni
- enzyme binding Source: UniProtKB
- microtubule binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 111419, 47 interactors |
CORUMi | P06746 |
IntActi | P06746, 33 interactors |
STRINGi | 9606.ENSP00000265421 |
Chemistry databases
BindingDBi | P06746 |
Miscellaneous databases
RNActi | P06746, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P06746 |
SMRi | P06746 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P06746 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 183 – 192 | DNA binding | 10 |
Domaini
Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity.By similarity
Sequence similaritiesi
Belongs to the DNA polymerase type-X family.Curated
Phylogenomic databases
eggNOGi | KOG2534, Eukaryota |
GeneTreei | ENSGT00940000156918 |
HOGENOMi | CLU_008698_1_0_1 |
InParanoidi | P06746 |
OMAi | ITDMLME |
OrthoDBi | 1328151at2759 |
PhylomeDBi | P06746 |
TreeFami | TF103002 |
Family and domain databases
CDDi | cd00141, NT_POLXc, 1 hit |
Gene3Di | 1.10.150.110, 1 hit 3.30.210.10, 1 hit 3.30.460.10, 1 hit |
InterProi | View protein in InterPro IPR002054, DNA-dir_DNA_pol_X IPR019843, DNA_pol-X_BS IPR010996, DNA_pol_b-like_N IPR028207, DNA_pol_B_palm_palm IPR018944, DNA_pol_lambd_fingers_domain IPR027421, DNA_pol_lamdba_lyase_dom_sf IPR037160, DNA_Pol_thumb_sf IPR022312, DNA_pol_X IPR002008, DNA_pol_X_beta-like IPR003583, Hlx-hairpin-Hlx_DNA-bd_motif IPR043519, NT_sf IPR029398, PolB_thumb |
Pfami | View protein in Pfam PF14792, DNA_pol_B_palm, 1 hit PF14791, DNA_pol_B_thumb, 1 hit PF10391, DNA_pol_lambd_f, 1 hit PF14716, HHH_8, 1 hit |
PRINTSi | PR00869, DNAPOLX PR00870, DNAPOLXBETA |
SMARTi | View protein in SMART SM00278, HhH1, 2 hits SM00483, POLXc, 1 hit |
SUPFAMi | SSF47802, SSF47802, 1 hit SSF81301, SSF81301, 1 hit |
PROSITEi | View protein in PROSITE PS00522, DNA_POLYMERASE_X, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All
P06746-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKRKAPQET LNGGITDMLT ELANFEKNVS QAIHKYNAYR KAASVIAKYP
60 70 80 90 100
HKIKSGAEAK KLPGVGTKIA EKIDEFLATG KLRKLEKIRQ DDTSSSINFL
110 120 130 140 150
TRVSGIGPSA ARKFVDEGIK TLEDLRKNED KLNHHQRIGL KYFGDFEKRI
160 170 180 190 200
PREEMLQMQD IVLNEVKKVD SEYIATVCGS FRRGAESSGD MDVLLTHPSF
210 220 230 240 250
TSESTKQPKL LHQVVEQLQK VHFITDTLSK GETKFMGVCQ LPSKNDEKEY
260 270 280 290 300
PHRRIDIRLI PKDQYYCGVL YFTGSDIFNK NMRAHALEKG FTINEYTIRP
310 320 330
LGVTGVAGEP LPVDSEKDIF DYIQWKYREP KDRSE
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE5RIJ0 | E5RIJ0_HUMAN | DNA polymerase | POLB | 193 | Annotation score: | ||
H0YBJ0 | H0YBJ0_HUMAN | DNA polymerase | POLB | 237 | Annotation score: | ||
H0YBX1 | H0YBX1_HUMAN | DNA polymerase | POLB | 239 | Annotation score: | ||
E7EW18 | E7EW18_HUMAN | DNA polymerase beta | POLB | 280 | Annotation score: | ||
E5RJ55 | E5RJ55_HUMAN | DNA polymerase beta | POLB | 51 | Annotation score: | ||
E9PIC6 | E9PIC6_HUMAN | DNA polymerase beta | POLB | 38 | Annotation score: | ||
E5RHZ4 | E5RHZ4_HUMAN | DNA polymerase beta | POLB | 54 | Annotation score: | ||
H0YAV8 | H0YAV8_HUMAN | DNA polymerase beta | POLB | 106 | Annotation score: | ||
E5RG65 | E5RG65_HUMAN | DNA polymerase beta | POLB | 42 | Annotation score: | ||
H0YB29 | H0YB29_HUMAN | DNA polymerase beta | POLB | 29 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 18 | M → K in AAB60688 (PubMed:7914364).Curated | 1 | |
Sequence conflicti | 228 | L → R in AAA60133 (PubMed:2423078).Curated | 1 | |
Sequence conflicti | 260 | I → Y in AAA60133 (PubMed:2423078).Curated | 1 | |
Sequence conflicti | 287 | L → K in AAA60133 (PubMed:2423078).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_018881 | 242 | P → R1 PublicationCorresponds to variant dbSNP:rs3136797Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L11607 mRNA Translation: AAB59441.1 D29013 mRNA Translation: BAA06099.1 U10526 , U10516, U10517, U10519, U10520, U10521, U10522, U10523, U10524, U10525 Genomic DNA Translation: AAB60688.1 AK314976 mRNA Translation: BAG37475.1 CR536503 mRNA Translation: CAG38741.1 CR541802 mRNA Translation: CAG46601.1 AF491812 Genomic DNA Translation: AAL91594.1 BC100288 mRNA Translation: AAI00289.1 BC106909 mRNA Translation: AAI06910.1 J04201 Genomic DNA Translation: AAA60134.1 M13140 mRNA Translation: AAA60133.1 |
CCDSi | CCDS6129.1 |
PIRi | I55273 S48061 |
RefSeqi | NP_002681.1, NM_002690.2 |
Genome annotation databases
Ensembli | ENST00000265421; ENSP00000265421; ENSG00000070501 |
GeneIDi | 5423 |
KEGGi | hsa:5423 |
UCSCi | uc003xoz.3, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L11607 mRNA Translation: AAB59441.1 D29013 mRNA Translation: BAA06099.1 U10526 , U10516, U10517, U10519, U10520, U10521, U10522, U10523, U10524, U10525 Genomic DNA Translation: AAB60688.1 AK314976 mRNA Translation: BAG37475.1 CR536503 mRNA Translation: CAG38741.1 CR541802 mRNA Translation: CAG46601.1 AF491812 Genomic DNA Translation: AAL91594.1 BC100288 mRNA Translation: AAI00289.1 BC106909 mRNA Translation: AAI06910.1 J04201 Genomic DNA Translation: AAA60134.1 M13140 mRNA Translation: AAA60133.1 |
CCDSi | CCDS6129.1 |
PIRi | I55273 S48061 |
RefSeqi | NP_002681.1, NM_002690.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BPX | X-ray | 2.40 | A | 1-335 | [»] | |
1BPY | X-ray | 2.20 | A | 1-335 | [»] | |
1BPZ | X-ray | 2.60 | A | 1-335 | [»] | |
1MQ2 | X-ray | 3.10 | A | 1-335 | [»] | |
1MQ3 | X-ray | 2.80 | A | 1-335 | [»] | |
1TV9 | X-ray | 2.00 | A | 1-335 | [»] | |
1TVA | X-ray | 2.60 | A | 1-335 | [»] | |
1ZJM | X-ray | 2.10 | A | 1-335 | [»] | |
1ZJN | X-ray | 2.61 | A | 1-335 | [»] | |
1ZQA | X-ray | 3.20 | A | 1-335 | [»] | |
1ZQB | X-ray | 3.20 | A | 1-335 | [»] | |
1ZQC | X-ray | 3.20 | A | 1-335 | [»] | |
1ZQD | X-ray | 3.50 | A | 1-335 | [»] | |
1ZQE | X-ray | 3.70 | A | 1-335 | [»] | |
1ZQF | X-ray | 2.90 | A | 1-335 | [»] | |
1ZQG | X-ray | 3.10 | A | 1-335 | [»] | |
1ZQH | X-ray | 3.10 | A | 1-335 | [»] | |
1ZQI | X-ray | 2.70 | A | 1-335 | [»] | |
1ZQJ | X-ray | 3.30 | A | 1-335 | [»] | |
1ZQK | X-ray | 3.20 | A | 1-335 | [»] | |
1ZQL | X-ray | 3.30 | A | 1-335 | [»] | |
1ZQM | X-ray | 3.20 | A | 1-335 | [»] | |
1ZQN | X-ray | 3.00 | A | 1-335 | [»] | |
1ZQO | X-ray | 3.20 | A | 1-335 | [»] | |
1ZQP | X-ray | 2.80 | A | 1-335 | [»] | |
1ZQQ | X-ray | 3.30 | A | 1-335 | [»] | |
1ZQR | X-ray | 3.70 | A | 1-335 | [»] | |
1ZQS | X-ray | 3.30 | A | 1-335 | [»] | |
1ZQT | X-ray | 3.40 | A | 1-335 | [»] | |
2FMP | X-ray | 1.65 | A | 1-335 | [»] | |
2FMQ | X-ray | 2.20 | A | 1-335 | [»] | |
2FMS | X-ray | 2.00 | A | 1-335 | [»] | |
2I9G | X-ray | 2.10 | A | 1-335 | [»] | |
2ISO | X-ray | 2.10 | A | 1-335 | [»] | |
2ISP | X-ray | 2.20 | A | 1-335 | [»] | |
2P66 | X-ray | 2.50 | A | 1-335 | [»] | |
2PXI | X-ray | 2.10 | A | 1-335 | [»] | |
3C2K | X-ray | 2.40 | A | 1-335 | [»] | |
3C2L | X-ray | 2.60 | A | 1-335 | [»] | |
3C2M | X-ray | 2.15 | A | 1-335 | [»] | |
3GDX | X-ray | 2.20 | A | 10-335 | [»] | |
3ISB | X-ray | 2.00 | A | 1-335 | [»] | |
3ISC | X-ray | 2.00 | A | 1-335 | [»] | |
3ISD | X-ray | 2.60 | A | 1-335 | [»] | |
3JPN | X-ray | 2.15 | A | 1-335 | [»] | |
3JPO | X-ray | 2.00 | A | 1-335 | [»] | |
3JPP | X-ray | 2.10 | A | 1-335 | [»] | |
3JPQ | X-ray | 1.90 | A | 1-335 | [»] | |
3JPR | X-ray | 2.10 | A | 1-335 | [»] | |
3JPS | X-ray | 2.00 | A | 1-335 | [»] | |
3JPT | X-ray | 2.15 | A | 1-335 | [»] | |
3LK9 | X-ray | 2.50 | A | 1-335 | [»] | |
3MBY | X-ray | 2.00 | A | 1-335 | [»] | |
3OGU | X-ray | 1.84 | A | 1-335 | [»] | |
3RH4 | X-ray | 1.92 | A | 1-335 | [»] | |
3RH5 | X-ray | 2.10 | A | 1-335 | [»] | |
3RH6 | X-ray | 2.05 | A | 1-335 | [»] | |
3RJE | X-ray | 2.10 | A | 1-335 | [»] | |
3RJF | X-ray | 2.30 | A | 1-335 | [»] | |
3RJG | X-ray | 2.00 | A | 1-335 | [»] | |
3RJH | X-ray | 2.20 | A | 1-335 | [»] | |
3RJI | X-ray | 2.30 | A | 1-335 | [»] | |
3RJJ | X-ray | 2.00 | A | 1-335 | [»] | |
3RJK | X-ray | 2.10 | A | 1-335 | [»] | |
3TFR | X-ray | 2.00 | A | 1-335 | [»] | |
3TFS | X-ray | 2.00 | A | 1-335 | [»] | |
4DO9 | X-ray | 2.05 | A | 1-335 | [»] | |
4DOA | X-ray | 2.05 | A | 1-335 | [»] | |
4DOB | X-ray | 2.05 | A | 1-335 | [»] | |
4DOC | X-ray | 1.95 | A | 1-335 | [»] | |
4F5N | X-ray | 1.80 | A | 1-335 | [»] | |
4F5O | X-ray | 2.00 | A | 1-335 | [»] | |
4F5P | X-ray | 1.85 | A | 1-335 | [»] | |
4F5Q | X-ray | 2.25 | A | 1-335 | [»] | |
4F5R | X-ray | 2.20 | A/B | 1-335 | [»] | |
4GXI | X-ray | 1.95 | A | 1-335 | [»] | |
4GXJ | X-ray | 2.20 | A | 1-335 | [»] | |
4GXK | X-ray | 2.00 | A | 1-335 | [»] | |
4JWM | X-ray | 2.00 | A | 1-335 | [»] | |
4JWN | X-ray | 2.39 | A | 1-335 | [»] | |
4KLD | X-ray | 1.92 | A | 1-335 | [»] | |
4KLE | X-ray | 1.97 | A | 1-335 | [»] | |
4KLF | X-ray | 1.85 | A | 1-335 | [»] | |
4KLG | X-ray | 1.70 | A | 1-335 | [»] | |
4KLH | X-ray | 1.88 | A | 1-335 | [»] | |
4KLI | X-ray | 1.60 | A | 1-335 | [»] | |
4KLJ | X-ray | 1.80 | A | 1-335 | [»] | |
4KLL | X-ray | 1.84 | A | 1-335 | [»] | |
4KLM | X-ray | 1.75 | A | 1-335 | [»] | |
4KLO | X-ray | 1.84 | A | 1-335 | [»] | |
4KLQ | X-ray | 2.00 | A | 1-335 | [»] | |
4KLS | X-ray | 1.98 | A | 1-335 | [»] | |
4KLT | X-ray | 1.98 | A | 1-335 | [»] | |
4KLU | X-ray | 1.97 | A | 1-335 | [»] | |
4LVS | X-ray | 2.00 | A | 1-335 | [»] | |
4M2Y | X-ray | 2.27 | A | 11-335 | [»] | |
4M47 | X-ray | 2.37 | A | 12-335 | [»] | |
4M9G | X-ray | 2.01 | A | 1-335 | [»] | |
4M9H | X-ray | 2.39 | A | 1-335 | [»] | |
4M9J | X-ray | 2.04 | A | 1-335 | [»] | |
4M9L | X-ray | 2.09 | A | 1-335 | [»] | |
4M9N | X-ray | 2.28 | A | 1-335 | [»] | |
4MF2 | X-ray | 2.40 | A | 11-335 | [»] | |
4MF8 | X-ray | 2.32 | A | 7-335 | [»] | |
4MFA | X-ray | 2.27 | A | 11-335 | [»] | |
4MFC | X-ray | 2.13 | A | 11-335 | [»] | |
4MFF | X-ray | 2.55 | A | 11-335 | [»] | |
4NLK | X-ray | 2.49 | A | 7-335 | [»] | |
4NLN | X-ray | 2.26 | A | 7-335 | [»] | |
4NLZ | X-ray | 2.68 | A | 7-335 | [»] | |
4NM1 | X-ray | 2.42 | A | 7-335 | [»] | |
4NM2 | X-ray | 2.52 | A | 7-335 | [»] | |
4NXZ | X-ray | 2.56 | A | 10-335 | [»] | |
4NY8 | X-ray | 2.25 | A | 10-335 | [»] | |
4O5C | X-ray | 2.36 | A | 7-335 | [»] | |
4O5E | X-ray | 2.53 | A | 7-335 | [»] | |
4O5K | X-ray | 2.06 | A | 10-335 | [»] | |
4O9M | X-ray | 2.30 | A | 1-335 | [»] | |
4P2H | X-ray | 1.99 | A | 10-335 | [»] | |
4PGQ | X-ray | 2.30 | A | 7-335 | [»] | |
4PGX | X-ray | 2.08 | A | 10-335 | [»] | |
4PGY | X-ray | 2.26 | A | 7-335 | [»] | |
4PH5 | X-ray | 2.55 | A | 10-335 | [»] | |
4PHA | X-ray | 2.52 | A | 7-335 | [»] | |
4PHD | X-ray | 2.21 | A | 7-335 | [»] | |
4PHE | X-ray | 2.15 | A | 7-335 | [»] | |
4PHP | X-ray | 2.60 | A | 10-335 | [»] | |
4PPX | X-ray | 2.08 | A | 1-335 | [»] | |
4R63 | X-ray | 1.85 | A | 1-335 | [»] | |
4R64 | X-ray | 2.20 | A | 1-335 | [»] | |
4R65 | X-ray | 1.95 | A | 1-335 | [»] | |
4R66 | X-ray | 2.25 | A | 1-335 | [»] | |
4RPX | X-ray | 1.90 | A | 1-335 | [»] | |
4RPY | X-ray | 1.90 | A | 1-335 | [»] | |
4RPZ | X-ray | 2.19 | A | 1-335 | [»] | |
4RQ0 | X-ray | 2.20 | A | 1-335 | [»] | |
4RQ1 | X-ray | 2.70 | A | 1-335 | [»] | |
4RQ2 | X-ray | 2.20 | A | 1-335 | [»] | |
4RQ3 | X-ray | 2.00 | A | 1-335 | [»] | |
4RQ4 | X-ray | 2.10 | A | 1-335 | [»] | |
4RQ5 | X-ray | 2.32 | A | 1-335 | [»] | |
4RQ6 | X-ray | 2.25 | A | 1-335 | [»] | |
4RQ7 | X-ray | 2.00 | A | 1-335 | [»] | |
4RQ8 | X-ray | 2.00 | A | 1-335 | [»] | |
4RT2 | X-ray | 1.92 | A | 1-335 | [»] | |
4RT3 | X-ray | 1.92 | A | 1-335 | [»] | |
4TUP | X-ray | 1.80 | A | 7-335 | [»] | |
4TUQ | X-ray | 2.37 | A | 10-335 | [»] | |
4TUR | X-ray | 2.17 | A | 7-335 | [»] | |
4TUS | X-ray | 2.42 | A | 10-335 | [»] | |
4UAW | X-ray | 1.90 | A | 1-335 | [»] | |
4UAY | X-ray | 1.98 | A | 1-335 | [»] | |
4UAZ | X-ray | 1.88 | A | 1-335 | [»] | |
4UB1 | X-ray | 2.34 | A | 1-335 | [»] | |
4UB2 | X-ray | 2.51 | A | 1-335 | [»] | |
4UB3 | X-ray | 2.06 | A | 1-335 | [»] | |
4UB4 | X-ray | 1.95 | A | 1-335 | [»] | |
4UB5 | X-ray | 2.15 | A | 1-335 | [»] | |
4UBB | X-ray | 1.90 | A | 1-335 | [»] | |
4UBC | X-ray | 2.00 | A | 1-335 | [»] | |
4YMM | X-ray | 2.20 | A | 1-335 | [»] | |
4YMN | X-ray | 2.59 | A | 1-335 | [»] | |
4YMO | X-ray | 2.15 | A | 1-335 | [»] | |
4YN4 | X-ray | 2.24 | A | 1-335 | [»] | |
4Z6C | X-ray | 2.68 | A | 1-335 | [»] | |
4Z6D | X-ray | 2.51 | A | 1-335 | [»] | |
4Z6E | X-ray | 2.75 | A | 1-335 | [»] | |
4Z6F | X-ray | 2.44 | A | 1-335 | [»] | |
5BOL | X-ray | 1.98 | A | 1-335 | [»] | |
5BOM | X-ray | 2.00 | A | 1-335 | [»] | |
5BPC | X-ray | 2.00 | A | 1-335 | [»] | |
5DB6 | X-ray | 2.83 | A | 1-335 | [»] | |
5DB7 | X-ray | 2.21 | A | 1-335 | [»] | |
5DB8 | X-ray | 2.55 | A | 1-335 | [»] | |
5DB9 | X-ray | 2.45 | A | 1-335 | [»] | |
5DBA | X-ray | 1.97 | A | 1-335 | [»] | |
5DBB | X-ray | 2.25 | A | 1-335 | [»] | |
5DBC | X-ray | 2.40 | A | 1-335 | [»] | |
5EOZ | X-ray | 2.09 | A | 1-335 | [»] | |
5HHH | X-ray | 2.36 | A | 9-335 | [»] | |
5HHI | X-ray | 2.52 | A | 7-335 | [»] | |
5J0O | X-ray | 2.00 | A | 1-335 | [»] | |
5J0P | X-ray | 2.20 | A | 1-335 | [»] | |
5J0Q | X-ray | 2.00 | A | 1-335 | [»] | |
5J0R | X-ray | 2.00 | A | 1-335 | [»] | |
5J0S | X-ray | 2.00 | A | 1-335 | [»] | |
5J0T | X-ray | 2.00 | A | 1-335 | [»] | |
5J0U | X-ray | 2.10 | A | 1-335 | [»] | |
5J0W | X-ray | 2.40 | A | 1-335 | [»] | |
5J0X | X-ray | 2.00 | A | 1-335 | [»] | |
5J0Y | X-ray | 2.00 | A | 1-335 | [»] | |
5J29 | X-ray | 2.20 | A | 1-335 | [»] | |
5J2A | X-ray | 2.50 | A | 1-335 | [»] | |
5J2B | X-ray | 2.50 | A | 1-335 | [»] | |
5J2C | X-ray | 2.10 | A | 1-335 | [»] | |
5J2D | X-ray | 2.10 | A | 1-335 | [»] | |
5J2E | X-ray | 2.10 | A | 1-335 | [»] | |
5J2F | X-ray | 2.10 | A | 1-335 | [»] | |
5J2G | X-ray | 2.10 | A | 1-335 | [»] | |
5J2H | X-ray | 2.30 | A | 1-335 | [»] | |
5J2I | X-ray | 2.40 | A | 1-335 | [»] | |
5J2J | X-ray | 2.20 | A | 1-335 | [»] | |
5J2K | X-ray | 2.10 | A | 1-335 | [»] | |
5TB8 | X-ray | 2.00 | A | 1-335 | [»] | |
5TB9 | X-ray | 2.49 | A | 1-335 | [»] | |
5TBA | X-ray | 2.49 | A | 1-335 | [»] | |
5TBB | X-ray | 2.39 | A | 1-335 | [»] | |
5TBC | X-ray | 1.85 | A | 1-335 | [»] | |
5TZV | X-ray | 2.00 | A | 1-335 | [»] | |
5U2R | X-ray | 1.80 | A | 1-335 | [»] | |
5U2S | X-ray | 2.30 | A | 1-335 | [»] | |
5U2T | X-ray | 1.79 | A | 1-335 | [»] | |
5U8G | X-ray | 2.17 | A | 1-335 | [»] | |
5U8H | X-ray | 2.15 | A | 1-335 | [»] | |
5U8I | X-ray | 2.45 | A | 1-335 | [»] | |
5U9H | X-ray | 1.85 | A | 1-335 | [»] | |
5UGN | X-ray | 2.00 | A | 1-335 | [»] | |
5UGO | X-ray | 1.90 | A | 1-335 | [»] | |
5UGP | X-ray | 1.96 | A | 1-335 | [»] | |
5V1F | X-ray | 2.18 | A | 1-335 | [»] | |
5V1G | X-ray | 1.80 | A | 1-335 | [»] | |
5V1H | X-ray | 1.95 | A | 1-335 | [»] | |
5V1I | X-ray | 2.04 | A | 1-335 | [»] | |
5V1J | X-ray | 2.62 | A | 1-335 | [»] | |
5V1N | X-ray | 2.00 | A | 1-335 | [»] | |
5V1O | X-ray | 1.80 | A | 1-335 | [»] | |
5V1P | X-ray | 1.99 | A | 1-335 | [»] | |
5V1R | X-ray | 2.08 | A | 1-335 | [»] | |
5VEZ | X-ray | 2.04 | A | 1-335 | [»] | |
5VRW | X-ray | 2.58 | A | 1-335 | [»] | |
5VRX | X-ray | 2.20 | A | 1-335 | [»] | |
5VRY | X-ray | 1.90 | A | 1-335 | [»] | |
5VRZ | X-ray | 2.05 | A | 1-335 | [»] | |
5VS0 | X-ray | 2.10 | A | 1-335 | [»] | |
5VS1 | X-ray | 2.50 | A | 1-335 | [»] | |
5VS2 | X-ray | 2.33 | A | 1-335 | [»] | |
5VS3 | X-ray | 1.70 | A | 1-335 | [»] | |
5VS4 | X-ray | 1.87 | A | 1-335 | [»] | |
5WNX | X-ray | 2.55 | A | 1-335 | [»] | |
5WNY | X-ray | 2.10 | A | 1-335 | [»] | |
5WNZ | X-ray | 2.20 | A | 1-335 | [»] | |
5WO0 | X-ray | 1.60 | A | 1-335 | [»] | |
6BEL | X-ray | 1.90 | A | 1-335 | [»] | |
6BEM | X-ray | 1.88 | A | 1-335 | [»] | |
6BTE | X-ray | 2.20 | A | 1-335 | [»] | |
6BTF | X-ray | 1.75 | A | 1-335 | [»] | |
6CLY | X-ray | 2.19 | A | 1-335 | [»] | |
6CPQ | X-ray | 1.93 | A | 1-335 | [»] | |
6CR3 | X-ray | 1.95 | A | 1-335 | [»] | |
6CR4 | X-ray | 1.80 | A | 1-335 | [»] | |
6CR5 | X-ray | 1.98 | A | 1-335 | [»] | |
6CR6 | X-ray | 2.10 | A | 1-335 | [»] | |
6CR7 | X-ray | 2.29 | A | 1-335 | [»] | |
6CR8 | X-ray | 2.05 | A | 1-335 | [»] | |
6CR9 | X-ray | 1.96 | A | 1-335 | [»] | |
6CRB | X-ray | 2.15 | A | 1-335 | [»] | |
6CRC | X-ray | 2.30 | A | 1-335 | [»] | |
6CRH | X-ray | 2.33 | A | 1-335 | [»] | |
6CTI | X-ray | 2.00 | A | 1-335 | [»] | |
6CTJ | X-ray | 2.10 | A | 1-335 | [»] | |
6CTK | X-ray | 2.15 | A | 1-335 | [»] | |
6CTL | X-ray | 2.00 | A | 1-335 | [»] | |
6CTM | X-ray | 2.10 | A | 1-335 | [»] | |
6CTN | X-ray | 1.92 | A | 1-335 | [»] | |
6CTO | X-ray | 2.04 | A | 1-335 | [»] | |
6CTP | X-ray | 2.20 | A | 1-335 | [»] | |
6CTQ | X-ray | 1.87 | A | 1-335 | [»] | |
6CTR | X-ray | 1.85 | A | 1-335 | [»] | |
6CTT | X-ray | 2.00 | A | 1-335 | [»] | |
6CTU | X-ray | 1.90 | A | 1-335 | [»] | |
6CTV | X-ray | 2.02 | A | 1-335 | [»] | |
6CTW | X-ray | 1.98 | A | 1-335 | [»] | |
6CTX | X-ray | 2.02 | A | 1-335 | [»] | |
6CU9 | X-ray | 2.04 | A | 1-335 | [»] | |
6CUA | X-ray | 2.17 | A | 1-335 | [»] | |
6CUB | X-ray | 2.05 | A | 1-335 | [»] | |
6DIA | X-ray | 1.97 | A | 1-335 | [»] | |
6DIC | X-ray | 1.99 | A | 1-335 | [»] | |
6E3R | X-ray | 2.26 | A | 1-335 | [»] | |
6E3V | X-ray | 1.96 | A | 1-335 | [»] | |
6E3W | X-ray | 2.02 | A | 1-335 | [»] | |
6E3X | X-ray | 2.65 | A | 1-335 | [»] | |
6G2Q | X-ray | 2.15 | A | 1-335 | [»] | |
6MR7 | X-ray | 2.14 | A | 1-335 | [»] | |
6MR8 | X-ray | 1.90 | A | 1-335 | [»] | |
6N2R | X-ray | 2.10 | A | 1-335 | [»] | |
6N2S | X-ray | 2.46 | A | 1-335 | [»] | |
6N2T | X-ray | 2.60 | A | 1-335 | [»] | |
6NKR | X-ray | 2.45 | A | 1-335 | [»] | |
6NKS | X-ray | 2.35 | A | 1-335 | [»] | |
6NKT | X-ray | 2.60 | A | 1-335 | [»] | |
6NKU | X-ray | 1.90 | A | 1-335 | [»] | |
6NKV | X-ray | 1.85 | A | 1-335 | [»] | |
6NKW | X-ray | 1.98 | A | 1-335 | [»] | |
6NKX | X-ray | 1.98 | A | 1-335 | [»] | |
6NKY | X-ray | 2.09 | A | 1-335 | [»] | |
6NKZ | X-ray | 2.01 | A | 1-335 | [»] | |
6NL0 | X-ray | 1.97 | A | 1-335 | [»] | |
6PH5 | X-ray | 2.60 | A | 1-335 | [»] | |
6PH6 | X-ray | 2.60 | A | 1-335 | [»] | |
6PKZ | X-ray | 2.74 | A | 1-335 | [»] | |
6U2O | X-ray | 2.30 | A | 1-335 | [»] | |
6U6B | X-ray | 3.11 | A | 1-335 | [»] | |
6UOK | X-ray | 2.55 | A/F | 1-335 | [»] | |
6UOL | X-ray | 1.94 | A | 1-335 | [»] | |
6UOM | X-ray | 2.05 | A | 1-335 | [»] | |
6W2M | X-ray | 2.00 | A | 1-335 | [»] | |
7ICE | X-ray | 2.80 | A | 1-335 | [»] | |
7ICF | X-ray | 3.10 | A | 1-335 | [»] | |
7ICG | X-ray | 3.00 | A | 1-335 | [»] | |
7ICH | X-ray | 2.90 | A | 1-335 | [»] | |
7ICI | X-ray | 2.80 | A | 1-335 | [»] | |
7ICJ | X-ray | 3.50 | A | 1-335 | [»] | |
7ICK | X-ray | 2.90 | A | 1-335 | [»] | |
7ICL | X-ray | 3.10 | A | 1-335 | [»] | |
7ICM | X-ray | 3.00 | A | 1-335 | [»] | |
7ICN | X-ray | 2.80 | A | 1-335 | [»] | |
7ICO | X-ray | 3.30 | A | 1-335 | [»] | |
7ICP | X-ray | 3.00 | A | 1-335 | [»] | |
7ICQ | X-ray | 2.90 | A | 1-335 | [»] | |
7ICR | X-ray | 3.00 | A | 1-335 | [»] | |
7ICS | X-ray | 2.80 | A | 1-335 | [»] | |
7ICT | X-ray | 2.80 | A | 1-335 | [»] | |
7ICU | X-ray | 3.30 | A | 1-335 | [»] | |
7ICV | X-ray | 2.80 | A | 1-335 | [»] | |
8ICA | X-ray | 3.00 | A | 1-335 | [»] | |
8ICB | X-ray | 3.10 | A | 1-335 | [»] | |
8ICC | X-ray | 2.80 | A | 1-335 | [»] | |
8ICE | X-ray | 3.20 | A | 1-335 | [»] | |
8ICF | X-ray | 2.90 | A | 1-335 | [»] | |
8ICG | X-ray | 3.30 | A | 1-335 | [»] | |
8ICH | X-ray | 3.30 | A | 1-335 | [»] | |
8ICI | X-ray | 2.80 | A | 1-335 | [»] | |
8ICJ | X-ray | 3.20 | A | 1-335 | [»] | |
8ICK | X-ray | 2.70 | A | 1-335 | [»] | |
8ICL | X-ray | 3.10 | A | 1-335 | [»] | |
8ICM | X-ray | 2.90 | A | 1-335 | [»] | |
8ICN | X-ray | 2.80 | A | 1-335 | [»] | |
8ICO | X-ray | 2.70 | A | 1-335 | [»] | |
8ICP | X-ray | 2.90 | A | 1-335 | [»] | |
8ICQ | X-ray | 3.00 | A | 1-335 | [»] | |
8ICR | X-ray | 2.90 | A | 1-335 | [»] | |
8ICS | X-ray | 2.90 | A | 1-335 | [»] | |
8ICT | X-ray | 3.10 | A | 1-335 | [»] | |
8ICU | X-ray | 3.00 | A | 1-335 | [»] | |
8ICV | X-ray | 3.20 | A | 1-335 | [»] | |
8ICW | X-ray | 3.30 | A | 1-335 | [»] | |
8ICX | X-ray | 3.00 | A | 1-335 | [»] | |
8ICY | X-ray | 3.10 | A | 1-335 | [»] | |
8ICZ | X-ray | 3.10 | A | 1-335 | [»] | |
9ICA | X-ray | 3.00 | A | 1-335 | [»] | |
9ICB | X-ray | 3.20 | A | 1-335 | [»] | |
9ICC | X-ray | 3.10 | A | 1-335 | [»] | |
9ICE | X-ray | 3.30 | A | 1-335 | [»] | |
9ICF | X-ray | 3.00 | A | 1-335 | [»] | |
9ICG | X-ray | 3.00 | A | 1-335 | [»] | |
9ICH | X-ray | 2.90 | A | 1-335 | [»] | |
9ICI | X-ray | 3.10 | A | 1-335 | [»] | |
9ICJ | X-ray | 3.10 | A | 1-335 | [»] | |
9ICK | X-ray | 2.70 | A | 1-335 | [»] | |
9ICL | X-ray | 2.80 | A | 1-335 | [»] | |
9ICM | X-ray | 2.90 | A | 1-335 | [»] | |
9ICN | X-ray | 3.00 | A | 1-335 | [»] | |
9ICO | X-ray | 2.90 | A | 1-335 | [»] | |
9ICP | X-ray | 3.10 | A | 1-335 | [»] | |
9ICQ | X-ray | 2.90 | A | 1-335 | [»] | |
9ICR | X-ray | 3.00 | A | 1-335 | [»] | |
9ICS | X-ray | 2.90 | A | 1-335 | [»] | |
9ICT | X-ray | 3.00 | A | 1-335 | [»] | |
9ICU | X-ray | 2.90 | A | 1-335 | [»] | |
9ICV | X-ray | 2.70 | A | 1-335 | [»] | |
9ICW | X-ray | 2.60 | A | 1-335 | [»] | |
9ICX | X-ray | 2.60 | A | 1-335 | [»] | |
9ICY | X-ray | 3.00 | A | 1-335 | [»] | |
BMRBi | P06746 | |||||
SMRi | P06746 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111419, 47 interactors |
CORUMi | P06746 |
IntActi | P06746, 33 interactors |
STRINGi | 9606.ENSP00000265421 |
Chemistry databases
BindingDBi | P06746 |
ChEMBLi | CHEMBL2392 |
DrugBanki | DB07479, (1S)-1,2,3,4-TETRAHYDRO-BENZO[C]PHENANTHRENE-2,3,4-TRIOL DB00987, Cytarabine DB03222, dATP DB14490, Ferrous ascorbate DB14491, Ferrous fumarate DB14488, Ferrous gluconate DB14501, Ferrous glycine sulfate DB14489, Ferrous succinate DB01592, Iron |
DrugCentrali | P06746 |
PTM databases
iPTMneti | P06746 |
PhosphoSitePlusi | P06746 |
Genetic variation databases
BioMutai | POLB |
DMDMi | 544186 |
Proteomic databases
EPDi | P06746 |
jPOSTi | P06746 |
MassIVEi | P06746 |
MaxQBi | P06746 |
PaxDbi | P06746 |
PeptideAtlasi | P06746 |
PRIDEi | P06746 |
ProteomicsDBi | 51926 |
Protocols and materials databases
Antibodypediai | 3175, 396 antibodies |
DNASUi | 5423 |
Genome annotation databases
Ensembli | ENST00000265421; ENSP00000265421; ENSG00000070501 |
GeneIDi | 5423 |
KEGGi | hsa:5423 |
UCSCi | uc003xoz.3, human |
Organism-specific databases
CTDi | 5423 |
DisGeNETi | 5423 |
GeneCardsi | POLB |
HGNCi | HGNC:9174, POLB |
HPAi | ENSG00000070501, Tissue enhanced (brain) |
MIMi | 174760, gene |
neXtProti | NX_P06746 |
OpenTargetsi | ENSG00000070501 |
PharmGKBi | PA276 |
VEuPathDBi | HostDB:ENSG00000070501.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2534, Eukaryota |
GeneTreei | ENSGT00940000156918 |
HOGENOMi | CLU_008698_1_0_1 |
InParanoidi | P06746 |
OMAi | ITDMLME |
OrthoDBi | 1328151at2759 |
PhylomeDBi | P06746 |
TreeFami | TF103002 |
Enzyme and pathway databases
BRENDAi | 2.7.7.7, 2681 4.2.99.B1, 2681 |
PathwayCommonsi | P06746 |
Reactomei | R-HSA-110362, POLB-Dependent Long Patch Base Excision Repair R-HSA-110373, Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110381, Resolution of AP sites via the single-nucleotide replacement pathway R-HSA-5649702, APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway R-HSA-5651801, PCNA-Dependent Long Patch Base Excision Repair R-HSA-5689880, Ub-specific processing proteases R-HSA-73930, Abasic sugar-phosphate removal via the single-nucleotide replacement pathway |
SIGNORi | P06746 |
Miscellaneous databases
BioGRID-ORCSi | 5423, 5 hits in 998 CRISPR screens |
ChiTaRSi | POLB, human |
EvolutionaryTracei | P06746 |
GeneWikii | DNA_polymerase_beta |
GenomeRNAii | 5423 |
Pharosi | P06746, Tchem |
PROi | PR:P06746 |
RNActi | P06746, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000070501, Expressed in cerebellar hemisphere and 236 other tissues |
ExpressionAtlasi | P06746, baseline and differential |
Genevisiblei | P06746, HS |
Family and domain databases
CDDi | cd00141, NT_POLXc, 1 hit |
Gene3Di | 1.10.150.110, 1 hit 3.30.210.10, 1 hit 3.30.460.10, 1 hit |
InterProi | View protein in InterPro IPR002054, DNA-dir_DNA_pol_X IPR019843, DNA_pol-X_BS IPR010996, DNA_pol_b-like_N IPR028207, DNA_pol_B_palm_palm IPR018944, DNA_pol_lambd_fingers_domain IPR027421, DNA_pol_lamdba_lyase_dom_sf IPR037160, DNA_Pol_thumb_sf IPR022312, DNA_pol_X IPR002008, DNA_pol_X_beta-like IPR003583, Hlx-hairpin-Hlx_DNA-bd_motif IPR043519, NT_sf IPR029398, PolB_thumb |
Pfami | View protein in Pfam PF14792, DNA_pol_B_palm, 1 hit PF14791, DNA_pol_B_thumb, 1 hit PF10391, DNA_pol_lambd_f, 1 hit PF14716, HHH_8, 1 hit |
PRINTSi | PR00869, DNAPOLX PR00870, DNAPOLXBETA |
SMARTi | View protein in SMART SM00278, HhH1, 2 hits SM00483, POLXc, 1 hit |
SUPFAMi | SSF47802, SSF47802, 1 hit SSF81301, SSF81301, 1 hit |
PROSITEi | View protein in PROSITE PS00522, DNA_POLYMERASE_X, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DPOLB_HUMAN | |
Accessioni | P06746Primary (citable) accession number: P06746 Secondary accession number(s): B2RC78, Q3KP48, Q6FI34 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | January 23, 2007 | |
Last modified: | April 7, 2021 | |
This is version 238 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families