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Protein

DNA polymerase beta

Gene

POLB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.4 Publications

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei72Schiff-base intermediate with DNA1
Metal bindingi101Sodium; via carbonyl oxygen1
Metal bindingi103Sodium; via carbonyl oxygen1
Metal bindingi106Sodium; via carbonyl oxygen1
Metal bindingi190Magnesium 11
Metal bindingi190Magnesium 21
Metal bindingi192Magnesium 11
Metal bindingi192Magnesium 21
Metal bindingi256Magnesium 21

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Lyase, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA replication, DNA synthesis
LigandMagnesium, Metal-binding, Sodium

Enzyme and pathway databases

BRENDAi2.7.7.7 2681
4.2.99.B1 2681
ReactomeiR-HSA-110362 POLB-Dependent Long Patch Base Excision Repair
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway
R-HSA-110381 Resolution of AP sites via the single-nucleotide replacement pathway
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-HSA-5689880 Ub-specific processing proteases
R-HSA-73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
SIGNORiP06746

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase beta (EC:2.7.7.7, EC:4.2.99.-)
Gene namesi
Name:POLB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000070501.11
HGNCiHGNC:9174 POLB
MIMi174760 gene
neXtProtiNX_P06746

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi35K → Q or R: Reduces DNA lyase activity slightly. 1 Publication1
Mutagenesisi39Y → Q: Abolishes DNA polymerase and DNA lyase activity. 1 Publication1
Mutagenesisi41K → R: Abolishes ubiquitination; when associated with R-61 and R-81. 1 Publication1
Mutagenesisi61K → R: Abolishes ubiquitination; when associated with R-41 and R-81. 1 Publication1
Mutagenesisi68K → Q or R: Reduces DNA lyase activity slightly. 1 Publication1
Mutagenesisi72K → Q or R: Abolishes DNA lyase activity. No effect on DNA polymerase activity. 1 Publication1
Mutagenesisi81K → R: Abolishes ubiquitination; when associated with R-41 and R-61. 1 Publication1
Mutagenesisi83R → K: Slight effect. Abolishes methylation by PRMT6 and impairs the polymerase activity; when associated with K-152. 1 Publication1
Mutagenesisi84K → R: No effect. 1 Publication1
Mutagenesisi152R → K: Slight effect. Abolishes methylation by PRMT6 and impairs the polymerase activity; when associated with K-83. 1 Publication1

Organism-specific databases

DisGeNETi5423
OpenTargetsiENSG00000070501
PharmGKBiPA276

Chemistry databases

ChEMBLiCHEMBL2392
DrugBankiDB03222 2'-Deoxyadenosine 5'-Triphosphate
DB00987 Cytarabine

Polymorphism and mutation databases

BioMutaiPOLB
DMDMi544186

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002187781 – 335DNA polymerase betaAdd BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki41Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Modified residuei72N6-acetyllysineBy similarity1
Cross-linki81Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Modified residuei83Omega-N-methylarginine; by PRMT61 Publication1
Modified residuei152Omega-N-methylarginine; by PRMT61 Publication1

Post-translational modificationi

Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.1 Publication
Ubiquitinated at Lys-41, Lys-61 and Lys-81: monoubiquitinated by HUWE1/ARF-BP1. Monoubiquitinated protein is then the target of STUB1/CHIP, which catalyzes polyubiquitination from monoubiquitin, leading to degradation by the proteasome. USP47 mediates the deubiquitination of monoubiquitinated protein, preventing polyubiquitination by STUB1/CHIP and its subsequent degradation.2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

EPDiP06746
MaxQBiP06746
PaxDbiP06746
PeptideAtlasiP06746
PRIDEiP06746
ProteomicsDBi51926

PTM databases

iPTMnetiP06746
PhosphoSitePlusiP06746

Expressioni

Gene expression databases

BgeeiENSG00000070501 Expressed in 225 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_POLB
ExpressionAtlasiP06746 baseline and differential
GenevisibleiP06746 HS

Organism-specific databases

HPAiCAB011616
HPA049104

Interactioni

Subunit structurei

Monomer. Interacts with APEX1, HUWE1/ARF-BP1, STUB1/CHIP and USP47. Interacts with FAM168A (PubMed:25260657).7 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111419, 39 interactors
CORUMiP06746
IntActiP06746, 17 interactors
STRINGi9606.ENSP00000265421

Chemistry databases

BindingDBiP06746

Structurei

Secondary structure

1335
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP06746
SMRiP06746
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06746

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni183 – 192DNA binding10

Domaini

Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity.By similarity

Sequence similaritiesi

Belongs to the DNA polymerase type-X family.Curated

Phylogenomic databases

eggNOGiKOG2534 Eukaryota
COG1796 LUCA
GeneTreeiENSGT00530000063002
HOGENOMiHOG000007787
HOVERGENiHBG002359
InParanoidiP06746
KOiK02330
OMAiDLFNKNM
OrthoDBiEOG091G0HMG
PhylomeDBiP06746
TreeFamiTF103002

Family and domain databases

CDDicd00141 NT_POLXc, 1 hit
Gene3Di1.10.150.110, 1 hit
3.30.210.10, 1 hit
InterProiView protein in InterPro
IPR002054 DNA-dir_DNA_pol_X
IPR019843 DNA_pol-X_BS
IPR010996 DNA_pol_b-like_N
IPR028207 DNA_pol_B_palm_palm
IPR018944 DNA_pol_lambd_fingers_domain
IPR027421 DNA_pol_lamdba_lyase_dom_sf
IPR037160 DNA_Pol_thumb_sf
IPR022312 DNA_pol_X
IPR002008 DNA_pol_X_beta-like
IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
IPR029398 PolB_thumb
PfamiView protein in Pfam
PF14792 DNA_pol_B_palm, 1 hit
PF14791 DNA_pol_B_thumb, 1 hit
PF10391 DNA_pol_lambd_f, 1 hit
PF14716 HHH_8, 1 hit
PRINTSiPR00869 DNAPOLX
PR00870 DNAPOLXBETA
SMARTiView protein in SMART
SM00278 HhH1, 2 hits
SM00483 POLXc, 1 hit
SUPFAMiSSF47802 SSF47802, 1 hit
PROSITEiView protein in PROSITE
PS00522 DNA_POLYMERASE_X, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.iShow all

P06746-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKRKAPQET LNGGITDMLT ELANFEKNVS QAIHKYNAYR KAASVIAKYP
60 70 80 90 100
HKIKSGAEAK KLPGVGTKIA EKIDEFLATG KLRKLEKIRQ DDTSSSINFL
110 120 130 140 150
TRVSGIGPSA ARKFVDEGIK TLEDLRKNED KLNHHQRIGL KYFGDFEKRI
160 170 180 190 200
PREEMLQMQD IVLNEVKKVD SEYIATVCGS FRRGAESSGD MDVLLTHPSF
210 220 230 240 250
TSESTKQPKL LHQVVEQLQK VHFITDTLSK GETKFMGVCQ LPSKNDEKEY
260 270 280 290 300
PHRRIDIRLI PKDQYYCGVL YFTGSDIFNK NMRAHALEKG FTINEYTIRP
310 320 330
LGVTGVAGEP LPVDSEKDIF DYIQWKYREP KDRSE
Length:335
Mass (Da):38,178
Last modified:January 23, 2007 - v3
Checksum:iFF9A6D0E6F9A9487
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBJ0H0YBJ0_HUMAN
DNA polymerase beta
POLB
237Annotation score:
E5RIJ0E5RIJ0_HUMAN
DNA polymerase beta
POLB
193Annotation score:
H0YBX1H0YBX1_HUMAN
DNA polymerase beta
POLB
239Annotation score:
E7EW18E7EW18_HUMAN
DNA polymerase beta
POLB
280Annotation score:
E9PIC6E9PIC6_HUMAN
DNA polymerase beta
POLB
38Annotation score:
E5RJ55E5RJ55_HUMAN
DNA polymerase beta
POLB
51Annotation score:
E5RHZ4E5RHZ4_HUMAN
DNA polymerase beta
POLB
54Annotation score:
E5RG65E5RG65_HUMAN
DNA polymerase beta
POLB
42Annotation score:
H0YAV8H0YAV8_HUMAN
DNA polymerase beta
POLB
106Annotation score:
H0YB29H0YB29_HUMAN
DNA polymerase beta
POLB
29Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18M → K in AAB60688 (PubMed:7914364).Curated1
Sequence conflicti228L → R in AAA60133 (PubMed:2423078).Curated1
Sequence conflicti260I → Y in AAA60133 (PubMed:2423078).Curated1
Sequence conflicti287L → K in AAA60133 (PubMed:2423078).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018881242P → R1 PublicationCorresponds to variant dbSNP:rs3136797Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11607 mRNA Translation: AAB59441.1
D29013 mRNA Translation: BAA06099.1
U10526
, U10516, U10517, U10519, U10520, U10521, U10522, U10523, U10524, U10525 Genomic DNA Translation: AAB60688.1
AK314976 mRNA Translation: BAG37475.1
CR536503 mRNA Translation: CAG38741.1
CR541802 mRNA Translation: CAG46601.1
AF491812 Genomic DNA Translation: AAL91594.1
BC100288 mRNA Translation: AAI00289.1
BC106909 mRNA Translation: AAI06910.1
J04201 Genomic DNA Translation: AAA60134.1
M13140 mRNA Translation: AAA60133.1
CCDSiCCDS6129.1
PIRiI55273
S48061
RefSeqiNP_002681.1, NM_002690.2
UniGeneiHs.654484
Hs.661106

Genome annotation databases

EnsembliENST00000265421; ENSP00000265421; ENSG00000070501
GeneIDi5423
KEGGihsa:5423
UCSCiuc003xoz.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11607 mRNA Translation: AAB59441.1
D29013 mRNA Translation: BAA06099.1
U10526
, U10516, U10517, U10519, U10520, U10521, U10522, U10523, U10524, U10525 Genomic DNA Translation: AAB60688.1
AK314976 mRNA Translation: BAG37475.1
CR536503 mRNA Translation: CAG38741.1
CR541802 mRNA Translation: CAG46601.1
AF491812 Genomic DNA Translation: AAL91594.1
BC100288 mRNA Translation: AAI00289.1
BC106909 mRNA Translation: AAI06910.1
J04201 Genomic DNA Translation: AAA60134.1
M13140 mRNA Translation: AAA60133.1
CCDSiCCDS6129.1
PIRiI55273
S48061
RefSeqiNP_002681.1, NM_002690.2
UniGeneiHs.654484
Hs.661106

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BPXX-ray2.40A1-335[»]
1BPYX-ray2.20A1-335[»]
1BPZX-ray2.60A1-335[»]
1MQ2X-ray3.10A1-335[»]
1MQ3X-ray2.80A1-335[»]
1TV9X-ray2.00A1-335[»]
1TVAX-ray2.60A1-335[»]
1ZJMX-ray2.10A1-335[»]
1ZJNX-ray2.61A1-335[»]
1ZQAX-ray3.20A1-335[»]
1ZQBX-ray3.20A1-335[»]
1ZQCX-ray3.20A1-335[»]
1ZQDX-ray3.50A1-335[»]
1ZQEX-ray3.70A1-335[»]
1ZQFX-ray2.90A1-335[»]
1ZQGX-ray3.10A1-335[»]
1ZQHX-ray3.10A1-335[»]
1ZQIX-ray2.70A1-335[»]
1ZQJX-ray3.30A1-335[»]
1ZQKX-ray3.20A1-335[»]
1ZQLX-ray3.30A1-335[»]
1ZQMX-ray3.20A1-335[»]
1ZQNX-ray3.00A1-335[»]
1ZQOX-ray3.20A1-335[»]
1ZQPX-ray2.80A1-335[»]
1ZQQX-ray3.30A1-335[»]
1ZQRX-ray3.70A1-335[»]
1ZQSX-ray3.30A1-335[»]
1ZQTX-ray3.40A1-335[»]
2FMPX-ray1.65A1-335[»]
2FMQX-ray2.20A1-335[»]
2FMSX-ray2.00A1-335[»]
2I9GX-ray2.10A1-335[»]
2ISOX-ray2.10A1-335[»]
2ISPX-ray2.20A1-335[»]
2P66X-ray2.50A1-335[»]
2PXIX-ray2.10A1-335[»]
3C2KX-ray2.40A1-335[»]
3C2LX-ray2.60A1-335[»]
3C2MX-ray2.15A1-335[»]
3GDXX-ray2.20A10-335[»]
3ISBX-ray2.00A1-335[»]
3ISCX-ray2.00A1-335[»]
3ISDX-ray2.60A1-335[»]
3JPNX-ray2.15A1-335[»]
3JPOX-ray2.00A1-335[»]
3JPPX-ray2.10A1-335[»]
3JPQX-ray1.90A1-335[»]
3JPRX-ray2.10A1-335[»]
3JPSX-ray2.00A1-335[»]
3JPTX-ray2.15A1-335[»]
3LK9X-ray2.50A1-335[»]
3MBYX-ray2.00A1-335[»]
3OGUX-ray1.84A1-335[»]
3RH4X-ray1.92A1-335[»]
3RH5X-ray2.10A1-335[»]
3RH6X-ray2.05A1-335[»]
3RJEX-ray2.10A1-335[»]
3RJFX-ray2.30A1-335[»]
3RJGX-ray2.00A1-335[»]
3RJHX-ray2.20A1-335[»]
3RJIX-ray2.30A1-335[»]
3RJJX-ray2.00A1-335[»]
3RJKX-ray2.10A1-335[»]
3TFRX-ray2.00A1-335[»]
3TFSX-ray2.00A1-335[»]
4DO9X-ray2.05A1-335[»]
4DOAX-ray2.05A1-335[»]
4DOBX-ray2.05A1-335[»]
4DOCX-ray1.95A1-335[»]
4F5NX-ray1.80A1-335[»]
4F5OX-ray2.00A1-335[»]
4F5PX-ray1.85A1-335[»]
4F5QX-ray2.25A1-335[»]
4F5RX-ray2.20A/B1-335[»]
4GXIX-ray1.95A1-335[»]
4GXJX-ray2.20A1-335[»]
4GXKX-ray2.00A1-335[»]
4JWMX-ray2.00A1-335[»]
4JWNX-ray2.39A1-335[»]
4KLDX-ray1.92A1-335[»]
4KLEX-ray1.97A1-335[»]
4KLFX-ray1.85A1-335[»]
4KLGX-ray1.70A1-335[»]
4KLHX-ray1.88A1-335[»]
4KLIX-ray1.60A1-335[»]
4KLJX-ray1.80A1-335[»]
4KLLX-ray1.84A1-335[»]
4KLMX-ray1.75A1-335[»]
4KLOX-ray1.84A1-335[»]
4KLQX-ray2.00A1-335[»]
4KLSX-ray1.98A1-335[»]
4KLTX-ray1.98A1-335[»]
4KLUX-ray1.97A1-335[»]
4LVSX-ray2.00A1-335[»]
4M2YX-ray2.27A11-335[»]
4M47X-ray2.37A12-335[»]
4M9GX-ray2.01A1-335[»]
4M9HX-ray2.39A1-335[»]
4M9JX-ray2.04A1-335[»]
4M9LX-ray2.09A1-335[»]
4M9NX-ray2.28A1-335[»]
4MF2X-ray2.40A11-335[»]
4MF8X-ray2.32A7-335[»]
4MFAX-ray2.27A11-335[»]
4MFCX-ray2.13A11-335[»]
4MFFX-ray2.55A11-335[»]
4NLKX-ray2.49A7-335[»]
4NLNX-ray2.26A7-335[»]
4NLZX-ray2.68A7-335[»]
4NM1X-ray2.42A7-335[»]
4NM2X-ray2.52A7-335[»]
4NXZX-ray2.56A10-335[»]
4NY8X-ray2.25A10-335[»]
4O5CX-ray2.36A7-335[»]
4O5EX-ray2.53A7-335[»]
4O5KX-ray2.06A10-335[»]
4O9MX-ray2.30A1-335[»]
4P2HX-ray1.99A10-335[»]
4PGQX-ray2.30A7-335[»]
4PGXX-ray2.08A10-335[»]
4PGYX-ray2.26A7-335[»]
4PH5X-ray2.55A10-335[»]
4PHAX-ray2.52A7-335[»]
4PHDX-ray2.21A7-335[»]
4PHEX-ray2.15A7-335[»]
4PHPX-ray2.60A10-335[»]
4PPXX-ray2.08A1-335[»]
4R63X-ray1.85A1-335[»]
4R64X-ray2.20A1-335[»]
4R65X-ray1.95A1-335[»]
4R66X-ray2.25A1-335[»]
4RPXX-ray1.90A1-335[»]
4RPYX-ray1.90A1-335[»]
4RPZX-ray2.19A1-335[»]
4RQ0X-ray2.20A1-335[»]
4RQ1X-ray2.70A1-335[»]
4RQ2X-ray2.20A1-335[»]
4RQ3X-ray2.00A1-335[»]
4RQ4X-ray2.10A1-335[»]
4RQ5X-ray2.32A1-335[»]
4RQ6X-ray2.25A1-335[»]
4RQ7X-ray2.00A1-335[»]
4RQ8X-ray2.00A1-335[»]
4RT2X-ray1.92A1-335[»]
4RT3X-ray1.92A1-335[»]
4TUPX-ray1.80A7-335[»]
4TUQX-ray2.37A10-335[»]
4TURX-ray2.17A7-335[»]
4TUSX-ray2.42A10-335[»]
4UAWX-ray1.90A1-335[»]
4UAYX-ray1.98A1-335[»]
4UAZX-ray1.88A1-335[»]
4UB1X-ray2.34A1-335[»]
4UB2X-ray2.51A1-335[»]
4UB3X-ray2.06A1-335[»]
4UB4X-ray1.95A1-335[»]
4UB5X-ray2.15A1-335[»]
4UBBX-ray1.90A1-335[»]
4UBCX-ray2.00A1-335[»]
4YMMX-ray2.20A1-335[»]
4YMNX-ray2.59A1-335[»]
4YMOX-ray2.15A1-335[»]
4YN4X-ray2.24A1-335[»]
4Z6CX-ray2.68A1-335[»]
4Z6DX-ray2.51A1-335[»]
4Z6EX-ray2.75A1-335[»]
4Z6FX-ray2.44A1-335[»]
5BOLX-ray1.98A1-335[»]
5BOMX-ray2.00A1-335[»]
5BPCX-ray2.00A1-335[»]
5DB6X-ray2.83A1-335[»]
5DB7X-ray2.21A1-335[»]
5DB8X-ray2.55A1-335[»]
5DB9X-ray2.45A1-335[»]
5DBAX-ray1.97A1-335[»]
5DBBX-ray2.25A1-335[»]
5DBCX-ray2.40A1-335[»]
5EOZX-ray2.09A1-335[»]
5HHHX-ray2.36A9-335[»]
5HHIX-ray2.52A7-335[»]
5J0OX-ray2.00A1-335[»]
5J0PX-ray2.20A1-335[»]
5J0QX-ray2.00A1-335[»]
5J0RX-ray2.00A1-335[»]
5J0SX-ray2.00A1-335[»]
5J0TX-ray2.00A1-335[»]
5J0UX-ray2.10A1-335[»]
5J0WX-ray2.40A1-335[»]
5J0XX-ray2.00A1-335[»]
5J0YX-ray2.00A1-335[»]
5J29X-ray2.20A1-335[»]
5J2AX-ray2.50A1-335[»]
5J2BX-ray2.50A1-335[»]
5J2CX-ray2.10A1-335[»]
5J2DX-ray2.10A1-335[»]
5J2EX-ray2.10A1-335[»]
5J2FX-ray2.10A1-335[»]
5J2GX-ray2.10A1-335[»]
5J2HX-ray2.30A1-335[»]
5J2IX-ray2.40A1-335[»]
5J2JX-ray2.20A1-335[»]
5J2KX-ray2.10A1-335[»]
5TB8X-ray2.00A1-335[»]
5TB9X-ray2.49A1-335[»]
5TBAX-ray2.49A1-335[»]
5TBBX-ray2.39A1-335[»]
5TBCX-ray1.85A1-335[»]
5TZVX-ray2.00A1-335[»]
5U2RX-ray1.80A1-335[»]
5U2SX-ray2.30A1-335[»]
5U2TX-ray1.79A1-335[»]
5U8GX-ray2.17A1-335[»]
5U8HX-ray2.15A1-335[»]
5U8IX-ray2.45A1-335[»]
5U9HX-ray1.85A1-335[»]
5UGNX-ray2.00A1-335[»]
5UGOX-ray1.90A1-335[»]
5UGPX-ray1.96A1-335[»]
5V1FX-ray2.18A1-335[»]
5V1GX-ray1.80A1-335[»]
5V1HX-ray1.95A1-335[»]
5V1IX-ray2.04A1-335[»]
5V1JX-ray2.62A1-335[»]
5V1NX-ray2.00A1-335[»]
5V1OX-ray1.80A1-335[»]
5V1PX-ray1.99A1-335[»]
5V1RX-ray2.08A1-335[»]
5VEZX-ray2.04A1-335[»]
5VRWX-ray2.58A1-335[»]
5VRXX-ray2.20A1-335[»]
5VRYX-ray1.90A1-335[»]
5VRZX-ray2.05A1-335[»]
5VS0X-ray2.10A1-335[»]
5VS1X-ray2.50A1-335[»]
5VS2X-ray2.33A1-335[»]
5VS3X-ray1.70A1-335[»]
5VS4X-ray1.87A1-335[»]
5WNXX-ray2.55A1-335[»]
5WNYX-ray2.10A1-335[»]
5WNZX-ray2.20A1-335[»]
5WO0X-ray1.60A1-335[»]
6CR3X-ray1.95A1-335[»]
6CR7X-ray2.29A1-335[»]
6CR8X-ray2.05A1-335[»]
6CR9X-ray1.96A1-335[»]
6CTIX-ray2.00A1-335[»]
6CTJX-ray2.10A1-335[»]
6CTKX-ray2.15A1-335[»]
6CTLX-ray2.00A1-335[»]
6CTMX-ray2.10A1-335[»]
6CTNX-ray1.92A1-335[»]
6CTOX-ray2.04A1-335[»]
6CTPX-ray2.20A1-335[»]
6CTQX-ray1.87A1-335[»]
6CTRX-ray1.85A1-335[»]
6CTTX-ray2.00A1-335[»]
6CTUX-ray1.90A1-335[»]
6CTVX-ray2.02A1-335[»]
6CTWX-ray1.98A1-335[»]
6CTXX-ray2.02A1-335[»]
6G2QX-ray2.15A1-335[»]
7ICEX-ray2.80A1-335[»]
7ICFX-ray3.10A1-335[»]
7ICGX-ray3.00A1-335[»]
7ICHX-ray2.90A1-335[»]
7ICIX-ray2.80A1-335[»]
7ICJX-ray3.50A1-335[»]
7ICKX-ray2.90A1-335[»]
7ICLX-ray3.10A1-335[»]
7ICMX-ray3.00A1-335[»]
7ICNX-ray2.80A1-335[»]
7ICOX-ray3.30A1-335[»]
7ICPX-ray3.00A1-335[»]
7ICQX-ray2.90A1-335[»]
7ICRX-ray3.00A1-335[»]
7ICSX-ray2.80A1-335[»]
7ICTX-ray2.80A1-335[»]
7ICUX-ray3.30A1-335[»]
7ICVX-ray2.80A1-335[»]
8ICAX-ray3.00A1-335[»]
8ICBX-ray3.10A1-335[»]
8ICCX-ray2.80A1-335[»]
8ICEX-ray3.20A1-335[»]
8ICFX-ray2.90A1-335[»]
8ICGX-ray3.30A1-335[»]
8ICHX-ray3.30A1-335[»]
8ICIX-ray2.80A1-335[»]
8ICJX-ray3.20A1-335[»]
8ICKX-ray2.70A1-335[»]
8ICLX-ray3.10A1-335[»]
8ICMX-ray2.90A1-335[»]
8ICNX-ray2.80A1-335[»]
8ICOX-ray2.70A1-335[»]
8ICPX-ray2.90A1-335[»]
8ICQX-ray3.00A1-335[»]
8ICRX-ray2.90A1-335[»]
8ICSX-ray2.90A1-335[»]
8ICTX-ray3.10A1-335[»]
8ICUX-ray3.00A1-335[»]
8ICVX-ray3.20A1-335[»]
8ICWX-ray3.30A1-335[»]
8ICXX-ray3.00A1-335[»]
8ICYX-ray3.10A1-335[»]
8ICZX-ray3.10A1-335[»]
9ICAX-ray3.00A1-335[»]
9ICBX-ray3.20A1-335[»]
9ICCX-ray3.10A1-335[»]
9ICEX-ray3.30A1-335[»]
9ICFX-ray3.00A1-335[»]
9ICGX-ray3.00A1-335[»]
9ICHX-ray2.90A1-335[»]
9ICIX-ray3.10A1-335[»]
9ICJX-ray3.10A1-335[»]
9ICKX-ray2.70A1-335[»]
9ICLX-ray2.80A1-335[»]
9ICMX-ray2.90A1-335[»]
9ICNX-ray3.00A1-335[»]
9ICOX-ray2.90A1-335[»]
9ICPX-ray3.10A1-335[»]
9ICQX-ray2.90A1-335[»]
9ICRX-ray3.00A1-335[»]
9ICSX-ray2.90A1-335[»]
9ICTX-ray3.00A1-335[»]
9ICUX-ray2.90A1-335[»]
9ICVX-ray2.70A1-335[»]
9ICWX-ray2.60A1-335[»]
9ICXX-ray2.60A1-335[»]
9ICYX-ray3.00A1-335[»]
ProteinModelPortaliP06746
SMRiP06746
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111419, 39 interactors
CORUMiP06746
IntActiP06746, 17 interactors
STRINGi9606.ENSP00000265421

Chemistry databases

BindingDBiP06746
ChEMBLiCHEMBL2392
DrugBankiDB03222 2'-Deoxyadenosine 5'-Triphosphate
DB00987 Cytarabine

PTM databases

iPTMnetiP06746
PhosphoSitePlusiP06746

Polymorphism and mutation databases

BioMutaiPOLB
DMDMi544186

Proteomic databases

EPDiP06746
MaxQBiP06746
PaxDbiP06746
PeptideAtlasiP06746
PRIDEiP06746
ProteomicsDBi51926

Protocols and materials databases

DNASUi5423
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265421; ENSP00000265421; ENSG00000070501
GeneIDi5423
KEGGihsa:5423
UCSCiuc003xoz.3 human

Organism-specific databases

CTDi5423
DisGeNETi5423
EuPathDBiHostDB:ENSG00000070501.11
GeneCardsiPOLB
HGNCiHGNC:9174 POLB
HPAiCAB011616
HPA049104
MIMi174760 gene
neXtProtiNX_P06746
OpenTargetsiENSG00000070501
PharmGKBiPA276
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2534 Eukaryota
COG1796 LUCA
GeneTreeiENSGT00530000063002
HOGENOMiHOG000007787
HOVERGENiHBG002359
InParanoidiP06746
KOiK02330
OMAiDLFNKNM
OrthoDBiEOG091G0HMG
PhylomeDBiP06746
TreeFamiTF103002

Enzyme and pathway databases

BRENDAi2.7.7.7 2681
4.2.99.B1 2681
ReactomeiR-HSA-110362 POLB-Dependent Long Patch Base Excision Repair
R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway
R-HSA-110381 Resolution of AP sites via the single-nucleotide replacement pathway
R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-HSA-5689880 Ub-specific processing proteases
R-HSA-73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
SIGNORiP06746

Miscellaneous databases

ChiTaRSiPOLB human
EvolutionaryTraceiP06746
GeneWikiiDNA_polymerase_beta
GenomeRNAii5423
PROiPR:P06746
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000070501 Expressed in 225 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_POLB
ExpressionAtlasiP06746 baseline and differential
GenevisibleiP06746 HS

Family and domain databases

CDDicd00141 NT_POLXc, 1 hit
Gene3Di1.10.150.110, 1 hit
3.30.210.10, 1 hit
InterProiView protein in InterPro
IPR002054 DNA-dir_DNA_pol_X
IPR019843 DNA_pol-X_BS
IPR010996 DNA_pol_b-like_N
IPR028207 DNA_pol_B_palm_palm
IPR018944 DNA_pol_lambd_fingers_domain
IPR027421 DNA_pol_lamdba_lyase_dom_sf
IPR037160 DNA_Pol_thumb_sf
IPR022312 DNA_pol_X
IPR002008 DNA_pol_X_beta-like
IPR003583 Hlx-hairpin-Hlx_DNA-bd_motif
IPR029398 PolB_thumb
PfamiView protein in Pfam
PF14792 DNA_pol_B_palm, 1 hit
PF14791 DNA_pol_B_thumb, 1 hit
PF10391 DNA_pol_lambd_f, 1 hit
PF14716 HHH_8, 1 hit
PRINTSiPR00869 DNAPOLX
PR00870 DNAPOLXBETA
SMARTiView protein in SMART
SM00278 HhH1, 2 hits
SM00483 POLXc, 1 hit
SUPFAMiSSF47802 SSF47802, 1 hit
PROSITEiView protein in PROSITE
PS00522 DNA_POLYMERASE_X, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDPOLB_HUMAN
AccessioniPrimary (citable) accession number: P06746
Secondary accession number(s): B2RC78, Q3KP48, Q6FI34
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 218 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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