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UniProtKB - P06746 (DPOLB_HUMAN)

Entry version 235 (07 Oct 2020)
Sequence version 3 (23 Jan 2007)
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Protein

DNA polymerase beta

Gene

POLB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei72Schiff-base intermediate with DNA1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi101Sodium; via carbonyl oxygen1
Metal bindingi103Sodium; via carbonyl oxygen1
Metal bindingi106Sodium; via carbonyl oxygen1
Metal bindingi190Magnesium 11
Metal bindingi190Magnesium 21
Metal bindingi192Magnesium 11
Metal bindingi192Magnesium 21
Metal bindingi256Magnesium 21

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Lyase, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA replication, DNA synthesis
LigandMagnesium, Metal-binding, Sodium

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.7.7, 2681
4.2.99.B1, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P06746

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-110362, POLB-Dependent Long Patch Base Excision Repair
R-HSA-110373, Resolution of AP sites via the multiple-nucleotide patch replacement pathway
R-HSA-110381, Resolution of AP sites via the single-nucleotide replacement pathway
R-HSA-5649702, APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
R-HSA-5651801, PCNA-Dependent Long Patch Base Excision Repair
R-HSA-5689880, Ub-specific processing proteases
R-HSA-73930, Abasic sugar-phosphate removal via the single-nucleotide replacement pathway

SIGNOR Signaling Network Open Resource

More...SIGNORi		P06746

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA polymerase beta (EC:2.7.7.7, EC:4.2.99.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POLB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000070501.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:9174, POLB

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		174760, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P06746

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi35K → Q or R: Reduces DNA lyase activity slightly. 1 Publication1
Mutagenesisi39Y → Q: Abolishes DNA polymerase and DNA lyase activity. 1 Publication1
Mutagenesisi41K → R: Abolishes ubiquitination; when associated with R-61 and R-81. 1 Publication1
Mutagenesisi61K → R: Abolishes ubiquitination; when associated with R-41 and R-81. 1 Publication1
Mutagenesisi68K → Q or R: Reduces DNA lyase activity slightly. 1 Publication1
Mutagenesisi72K → Q or R: Abolishes DNA lyase activity. No effect on DNA polymerase activity. 1 Publication1
Mutagenesisi81K → R: Abolishes ubiquitination; when associated with R-41 and R-61. 1 Publication1
Mutagenesisi83R → K: Slight effect. Abolishes methylation by PRMT6 and impairs the polymerase activity; when associated with K-152. 1 Publication1
Mutagenesisi84K → R: No effect. 1 Publication1
Mutagenesisi152R → K: Slight effect. Abolishes methylation by PRMT6 and impairs the polymerase activity; when associated with K-83. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		5423

Open Targets

More...OpenTargetsi		ENSG00000070501

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA276

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P06746, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2392

Drug and drug target database

More...DrugBanki		DB07479, (1S)-1,2,3,4-TETRAHYDRO-BENZO[C]PHENANTHRENE-2,3,4-TRIOL
DB00987, Cytarabine
DB03222, dATP
DB14490, Ferrous ascorbate
DB14491, Ferrous fumarate
DB14488, Ferrous gluconate
DB14501, Ferrous glycine sulfate
DB14489, Ferrous succinate
DB01592, Iron

DrugCentral

More...DrugCentrali		P06746

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		POLB

Domain mapping of disease mutations (DMDM)

More...DMDMi		544186

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002187781 – 335DNA polymerase betaAdd BLAST335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki41Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei72N6-acetyllysineBy similarity1
Cross-linki81Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Modified residuei83Omega-N-methylarginine; by PRMT61 Publication1
Modified residuei152Omega-N-methylarginine; by PRMT61 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Methylation by PRMT6 stimulates the polymerase activity by enhancing DNA binding and processivity.1 Publication
Ubiquitinated at Lys-41, Lys-61 and Lys-81: monoubiquitinated by HUWE1/ARF-BP1. Monoubiquitinated protein is then the target of STUB1/CHIP, which catalyzes polyubiquitination from monoubiquitin, leading to degradation by the proteasome. USP47 mediates the deubiquitination of monoubiquitinated protein, preventing polyubiquitination by STUB1/CHIP and its subsequent degradation.2 Publications

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P06746

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P06746

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P06746

MaxQB - The MaxQuant DataBase

More...MaxQBi		P06746

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P06746

PeptideAtlas

More...PeptideAtlasi		P06746

PRoteomics IDEntifications database

More...PRIDEi		P06746

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51926

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P06746

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P06746

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000070501, Expressed in cerebellar hemisphere and 236 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P06746, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P06746, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000070501, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

Interacts with APEX1, HUWE1/ARF-BP1, STUB1/CHIP and USP47.

Interacts with FAM168A (PubMed:25260657).

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111419, 46 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P06746

Protein interaction database and analysis system

More...IntActi		P06746, 32 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000265421

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P06746

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P06746, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1335
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P06746

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P06746

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P06746

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni183 – 192DNA binding10

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Residues 239-252 form a flexible loop which appears to affect the polymerase fidelity.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNA polymerase type-X family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2534, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156918

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008698_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P06746

KEGG Orthology (KO)

More...KOi		K02330

Identification of Orthologs from Complete Genome Data

More...OMAi		ITDMLME

Database of Orthologous Groups

More...OrthoDBi		1328151at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P06746

TreeFam database of animal gene trees

More...TreeFami		TF103002

Family and domain databases

Conserved Domains Database

More...CDDi		cd00141, NT_POLXc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.110, 1 hit
3.30.210.10, 1 hit
3.30.460.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002054, DNA-dir_DNA_pol_X
IPR019843, DNA_pol-X_BS
IPR010996, DNA_pol_b-like_N
IPR028207, DNA_pol_B_palm_palm
IPR018944, DNA_pol_lambd_fingers_domain
IPR027421, DNA_pol_lamdba_lyase_dom_sf
IPR037160, DNA_Pol_thumb_sf
IPR022312, DNA_pol_X
IPR002008, DNA_pol_X_beta-like
IPR003583, Hlx-hairpin-Hlx_DNA-bd_motif
IPR043519, NT_sf
IPR029398, PolB_thumb

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14792, DNA_pol_B_palm, 1 hit
PF14791, DNA_pol_B_thumb, 1 hit
PF10391, DNA_pol_lambd_f, 1 hit
PF14716, HHH_8, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00869, DNAPOLX
PR00870, DNAPOLXBETA

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00278, HhH1, 2 hits
SM00483, POLXc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47802, SSF47802, 1 hit
SSF81301, SSF81301, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00522, DNA_POLYMERASE_X, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

P06746-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKRKAPQET LNGGITDMLT ELANFEKNVS QAIHKYNAYR KAASVIAKYP 
        60         70         80         90        100
HKIKSGAEAK KLPGVGTKIA EKIDEFLATG KLRKLEKIRQ DDTSSSINFL 
       110        120        130        140        150
TRVSGIGPSA ARKFVDEGIK TLEDLRKNED KLNHHQRIGL KYFGDFEKRI 
       160        170        180        190        200
PREEMLQMQD IVLNEVKKVD SEYIATVCGS FRRGAESSGD MDVLLTHPSF 
       210        220        230        240        250
TSESTKQPKL LHQVVEQLQK VHFITDTLSK GETKFMGVCQ LPSKNDEKEY 
       260        270        280        290        300
PHRRIDIRLI PKDQYYCGVL YFTGSDIFNK NMRAHALEKG FTINEYTIRP 
       310        320        330 
LGVTGVAGEP LPVDSEKDIF DYIQWKYREP KDRSE
Length:335
Mass (Da):38,178
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF9A6D0E6F9A9487
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RIJ0E5RIJ0_HUMAN
DNA polymerase
POLB
193Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBJ0H0YBJ0_HUMAN
DNA polymerase
POLB
237Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YBX1H0YBX1_HUMAN
DNA polymerase
POLB
239Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EW18E7EW18_HUMAN
DNA polymerase beta
POLB
280Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RJ55E5RJ55_HUMAN
DNA polymerase beta
POLB
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIC6E9PIC6_HUMAN
DNA polymerase beta
POLB
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHZ4E5RHZ4_HUMAN
DNA polymerase beta
POLB
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YAV8H0YAV8_HUMAN
DNA polymerase beta
POLB
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RG65E5RG65_HUMAN
DNA polymerase beta
POLB
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YB29H0YB29_HUMAN
DNA polymerase beta
POLB
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti18M → K in AAB60688 (PubMed:7914364).Curated1
Sequence conflicti228L → R in AAA60133 (PubMed:2423078).Curated1
Sequence conflicti260I → Y in AAA60133 (PubMed:2423078).Curated1
Sequence conflicti287L → K in AAA60133 (PubMed:2423078).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_018881242P → R1 PublicationCorresponds to variant dbSNP:rs3136797Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L11607 mRNA Translation: AAB59441.1
D29013 mRNA Translation: BAA06099.1
U10526 U10525 Genomic DNA Translation: AAB60688.1
AK314976 mRNA Translation: BAG37475.1
CR536503 mRNA Translation: CAG38741.1
CR541802 mRNA Translation: CAG46601.1
AF491812 Genomic DNA Translation: AAL91594.1
BC100288 mRNA Translation: AAI00289.1
BC106909 mRNA Translation: AAI06910.1
J04201 Genomic DNA Translation: AAA60134.1
M13140 mRNA Translation: AAA60133.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6129.1

Protein sequence database of the Protein Information Resource

More...PIRi		I55273
S48061

NCBI Reference Sequences

More...RefSeqi		NP_002681.1, NM_002690.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000265421; ENSP00000265421; ENSG00000070501

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5423

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5423

UCSC genome browser

More...UCSCi		uc003xoz.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11607 mRNA Translation: AAB59441.1
D29013 mRNA Translation: BAA06099.1
U10526 U10525 Genomic DNA Translation: AAB60688.1
AK314976 mRNA Translation: BAG37475.1
CR536503 mRNA Translation: CAG38741.1
CR541802 mRNA Translation: CAG46601.1
AF491812 Genomic DNA Translation: AAL91594.1
BC100288 mRNA Translation: AAI00289.1
BC106909 mRNA Translation: AAI06910.1
J04201 Genomic DNA Translation: AAA60134.1
M13140 mRNA Translation: AAA60133.1
CCDSiCCDS6129.1
PIRiI55273
S48061
RefSeqiNP_002681.1, NM_002690.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BPXX-ray2.40A1-335[»]
1BPYX-ray2.20A1-335[»]
1BPZX-ray2.60A1-335[»]
1MQ2X-ray3.10A1-335[»]
1MQ3X-ray2.80A1-335[»]
1TV9X-ray2.00A1-335[»]
1TVAX-ray2.60A1-335[»]
1ZJMX-ray2.10A1-335[»]
1ZJNX-ray2.61A1-335[»]
1ZQAX-ray3.20A1-335[»]
1ZQBX-ray3.20A1-335[»]
1ZQCX-ray3.20A1-335[»]
1ZQDX-ray3.50A1-335[»]
1ZQEX-ray3.70A1-335[»]
1ZQFX-ray2.90A1-335[»]
1ZQGX-ray3.10A1-335[»]
1ZQHX-ray3.10A1-335[»]
1ZQIX-ray2.70A1-335[»]
1ZQJX-ray3.30A1-335[»]
1ZQKX-ray3.20A1-335[»]
1ZQLX-ray3.30A1-335[»]
1ZQMX-ray3.20A1-335[»]
1ZQNX-ray3.00A1-335[»]
1ZQOX-ray3.20A1-335[»]
1ZQPX-ray2.80A1-335[»]
1ZQQX-ray3.30A1-335[»]
1ZQRX-ray3.70A1-335[»]
1ZQSX-ray3.30A1-335[»]
1ZQTX-ray3.40A1-335[»]
2FMPX-ray1.65A1-335[»]
2FMQX-ray2.20A1-335[»]
2FMSX-ray2.00A1-335[»]
2I9GX-ray2.10A1-335[»]
2ISOX-ray2.10A1-335[»]
2ISPX-ray2.20A1-335[»]
2P66X-ray2.50A1-335[»]
2PXIX-ray2.10A1-335[»]
3C2KX-ray2.40A1-335[»]
3C2LX-ray2.60A1-335[»]
3C2MX-ray2.15A1-335[»]
3GDXX-ray2.20A10-335[»]
3ISBX-ray2.00A1-335[»]
3ISCX-ray2.00A1-335[»]
3ISDX-ray2.60A1-335[»]
3JPNX-ray2.15A1-335[»]
3JPOX-ray2.00A1-335[»]
3JPPX-ray2.10A1-335[»]
3JPQX-ray1.90A1-335[»]
3JPRX-ray2.10A1-335[»]
3JPSX-ray2.00A1-335[»]
3JPTX-ray2.15A1-335[»]
3LK9X-ray2.50A1-335[»]
3MBYX-ray2.00A1-335[»]
3OGUX-ray1.84A1-335[»]
3RH4X-ray1.92A1-335[»]
3RH5X-ray2.10A1-335[»]
3RH6X-ray2.05A1-335[»]
3RJEX-ray2.10A1-335[»]
3RJFX-ray2.30A1-335[»]
3RJGX-ray2.00A1-335[»]
3RJHX-ray2.20A1-335[»]
3RJIX-ray2.30A1-335[»]
3RJJX-ray2.00A1-335[»]
3RJKX-ray2.10A1-335[»]
3TFRX-ray2.00A1-335[»]
3TFSX-ray2.00A1-335[»]
4DO9X-ray2.05A1-335[»]
4DOAX-ray2.05A1-335[»]
4DOBX-ray2.05A1-335[»]
4DOCX-ray1.95A1-335[»]
4F5NX-ray1.80A1-335[»]
4F5OX-ray2.00A1-335[»]
4F5PX-ray1.85A1-335[»]
4F5QX-ray2.25A1-335[»]
4F5RX-ray2.20A/B1-335[»]
4GXIX-ray1.95A1-335[»]
4GXJX-ray2.20A1-335[»]
4GXKX-ray2.00A1-335[»]
4JWMX-ray2.00A1-335[»]
4JWNX-ray2.39A1-335[»]
4KLDX-ray1.92A1-335[»]
4KLEX-ray1.97A1-335[»]
4KLFX-ray1.85A1-335[»]
4KLGX-ray1.70A1-335[»]
4KLHX-ray1.88A1-335[»]
4KLIX-ray1.60A1-335[»]
4KLJX-ray1.80A1-335[»]
4KLLX-ray1.84A1-335[»]
4KLMX-ray1.75A1-335[»]
4KLOX-ray1.84A1-335[»]
4KLQX-ray2.00A1-335[»]
4KLSX-ray1.98A1-335[»]
4KLTX-ray1.98A1-335[»]
4KLUX-ray1.97A1-335[»]
4LVSX-ray2.00A1-335[»]
4M2YX-ray2.27A11-335[»]
4M47X-ray2.37A12-335[»]
4M9GX-ray2.01A1-335[»]
4M9HX-ray2.39A1-335[»]
4M9JX-ray2.04A1-335[»]
4M9LX-ray2.09A1-335[»]
4M9NX-ray2.28A1-335[»]
4MF2X-ray2.40A11-335[»]
4MF8X-ray2.32A7-335[»]
4MFAX-ray2.27A11-335[»]
4MFCX-ray2.13A11-335[»]
4MFFX-ray2.55A11-335[»]
4NLKX-ray2.49A7-335[»]
4NLNX-ray2.26A7-335[»]
4NLZX-ray2.68A7-335[»]
4NM1X-ray2.42A7-335[»]
4NM2X-ray2.52A7-335[»]
4NXZX-ray2.56A10-335[»]
4NY8X-ray2.25A10-335[»]
4O5CX-ray2.36A7-335[»]
4O5EX-ray2.53A7-335[»]
4O5KX-ray2.06A10-335[»]
4O9MX-ray2.30A1-335[»]
4P2HX-ray1.99A10-335[»]
4PGQX-ray2.30A7-335[»]
4PGXX-ray2.08A10-335[»]
4PGYX-ray2.26A7-335[»]
4PH5X-ray2.55A10-335[»]
4PHAX-ray2.52A7-335[»]
4PHDX-ray2.21A7-335[»]
4PHEX-ray2.15A7-335[»]
4PHPX-ray2.60A10-335[»]
4PPXX-ray2.08A1-335[»]
4R63X-ray1.85A1-335[»]
4R64X-ray2.20A1-335[»]
4R65X-ray1.95A1-335[»]
4R66X-ray2.25A1-335[»]
4RPXX-ray1.90A1-335[»]
4RPYX-ray1.90A1-335[»]
4RPZX-ray2.19A1-335[»]
4RQ0X-ray2.20A1-335[»]
4RQ1X-ray2.70A1-335[»]
4RQ2X-ray2.20A1-335[»]
4RQ3X-ray2.00A1-335[»]
4RQ4X-ray2.10A1-335[»]
4RQ5X-ray2.32A1-335[»]
4RQ6X-ray2.25A1-335[»]
4RQ7X-ray2.00A1-335[»]
4RQ8X-ray2.00A1-335[»]
4RT2X-ray1.92A1-335[»]
4RT3X-ray1.92A1-335[»]
4TUPX-ray1.80A7-335[»]
4TUQX-ray2.37A10-335[»]
4TURX-ray2.17A7-335[»]
4TUSX-ray2.42A10-335[»]
4UAWX-ray1.90A1-335[»]
4UAYX-ray1.98A1-335[»]
4UAZX-ray1.88A1-335[»]
4UB1X-ray2.34A1-335[»]
4UB2X-ray2.51A1-335[»]
4UB3X-ray2.06A1-335[»]
4UB4X-ray1.95A1-335[»]
4UB5X-ray2.15A1-335[»]
4UBBX-ray1.90A1-335[»]
4UBCX-ray2.00A1-335[»]
4YMMX-ray2.20A1-335[»]
4YMNX-ray2.59A1-335[»]
4YMOX-ray2.15A1-335[»]
4YN4X-ray2.24A1-335[»]
4Z6CX-ray2.68A1-335[»]
4Z6DX-ray2.51A1-335[»]
4Z6EX-ray2.75A1-335[»]
4Z6FX-ray2.44A1-335[»]
5BOLX-ray1.98A1-335[»]
5BOMX-ray2.00A1-335[»]
5BPCX-ray2.00A1-335[»]
5DB6X-ray2.83A1-335[»]
5DB7X-ray2.21A1-335[»]
5DB8X-ray2.55A1-335[»]
5DB9X-ray2.45A1-335[»]
5DBAX-ray1.97A1-335[»]
5DBBX-ray2.25A1-335[»]
5DBCX-ray2.40A1-335[»]
5EOZX-ray2.09A1-335[»]
5HHHX-ray2.36A9-335[»]
5HHIX-ray2.52A7-335[»]
5J0OX-ray2.00A1-335[»]
5J0PX-ray2.20A1-335[»]
5J0QX-ray2.00A1-335[»]
5J0RX-ray2.00A1-335[»]
5J0SX-ray2.00A1-335[»]
5J0TX-ray2.00A1-335[»]
5J0UX-ray2.10A1-335[»]
5J0WX-ray2.40A1-335[»]
5J0XX-ray2.00A1-335[»]
5J0YX-ray2.00A1-335[»]
5J29X-ray2.20A1-335[»]
5J2AX-ray2.50A1-335[»]
5J2BX-ray2.50A1-335[»]
5J2CX-ray2.10A1-335[»]
5J2DX-ray2.10A1-335[»]
5J2EX-ray2.10A1-335[»]
5J2FX-ray2.10A1-335[»]
5J2GX-ray2.10A1-335[»]
5J2HX-ray2.30A1-335[»]
5J2IX-ray2.40A1-335[»]
5J2JX-ray2.20A1-335[»]
5J2KX-ray2.10A1-335[»]
5TB8X-ray2.00A1-335[»]
5TB9X-ray2.49A1-335[»]
5TBAX-ray2.49A1-335[»]
5TBBX-ray2.39A1-335[»]
5TBCX-ray1.85A1-335[»]
5TZVX-ray2.00A1-335[»]
5U2RX-ray1.80A1-335[»]
5U2SX-ray2.30A1-335[»]
5U2TX-ray1.79A1-335[»]
5U8GX-ray2.17A1-335[»]
5U8HX-ray2.15A1-335[»]
5U8IX-ray2.45A1-335[»]
5U9HX-ray1.85A1-335[»]
5UGNX-ray2.00A1-335[»]
5UGOX-ray1.90A1-335[»]
5UGPX-ray1.96A1-335[»]
5V1FX-ray2.18A1-335[»]
5V1GX-ray1.80A1-335[»]
5V1HX-ray1.95A1-335[»]
5V1IX-ray2.04A1-335[»]
5V1JX-ray2.62A1-335[»]
5V1NX-ray2.00A1-335[»]
5V1OX-ray1.80A1-335[»]
5V1PX-ray1.99A1-335[»]
5V1RX-ray2.08A1-335[»]
5VEZX-ray2.04A1-335[»]
5VRWX-ray2.58A1-335[»]
5VRXX-ray2.20A1-335[»]
5VRYX-ray1.90A1-335[»]
5VRZX-ray2.05A1-335[»]
5VS0X-ray2.10A1-335[»]
5VS1X-ray2.50A1-335[»]
5VS2X-ray2.33A1-335[»]
5VS3X-ray1.70A1-335[»]
5VS4X-ray1.87A1-335[»]
5WNXX-ray2.55A1-335[»]
5WNYX-ray2.10A1-335[»]
5WNZX-ray2.20A1-335[»]
5WO0X-ray1.60A1-335[»]
6BELX-ray1.90A1-335[»]
6BEMX-ray1.88A1-335[»]
6BTEX-ray2.20A1-335[»]
6BTFX-ray1.75A1-335[»]
6CLYX-ray2.19A1-335[»]
6CPQX-ray1.93A1-335[»]
6CR3X-ray1.95A1-335[»]
6CR4X-ray1.80A1-335[»]
6CR5X-ray1.98A1-335[»]
6CR6X-ray2.10A1-335[»]
6CR7X-ray2.29A1-335[»]
6CR8X-ray2.05A1-335[»]
6CR9X-ray1.96A1-335[»]
6CRBX-ray2.15A1-335[»]
6CRCX-ray2.30A1-335[»]
6CRHX-ray2.33A1-335[»]
6CTIX-ray2.00A1-335[»]
6CTJX-ray2.10A1-335[»]
6CTKX-ray2.15A1-335[»]
6CTLX-ray2.00A1-335[»]
6CTMX-ray2.10A1-335[»]
6CTNX-ray1.92A1-335[»]
6CTOX-ray2.04A1-335[»]
6CTPX-ray2.20A1-335[»]
6CTQX-ray1.87A1-335[»]
6CTRX-ray1.85A1-335[»]
6CTTX-ray2.00A1-335[»]
6CTUX-ray1.90A1-335[»]
6CTVX-ray2.02A1-335[»]
6CTWX-ray1.98A1-335[»]
6CTXX-ray2.02A1-335[»]
6CU9X-ray2.04A1-335[»]
6CUAX-ray2.17A1-335[»]
6CUBX-ray2.05A1-335[»]
6DIAX-ray1.97A1-335[»]
6DICX-ray1.99A1-335[»]
6E3RX-ray2.26A1-335[»]
6E3VX-ray1.96A1-335[»]
6E3WX-ray2.02A1-335[»]
6E3XX-ray2.65A1-335[»]
6G2QX-ray2.15A1-335[»]
6MR7X-ray2.14A1-335[»]
6MR8X-ray1.90A1-335[»]
6N2RX-ray2.10A1-335[»]
6N2SX-ray2.46A1-335[»]
6N2TX-ray2.60A1-335[»]
6NKRX-ray2.45A1-335[»]
6NKSX-ray2.35A1-335[»]
6NKTX-ray2.60A1-335[»]
6NKUX-ray1.90A1-335[»]
6NKVX-ray1.85A1-335[»]
6NKWX-ray1.98A1-335[»]
6NKXX-ray1.98A1-335[»]
6NKYX-ray2.09A1-335[»]
6NKZX-ray2.01A1-335[»]
6NL0X-ray1.97A1-335[»]
6PH5X-ray2.60A1-335[»]
6PH6X-ray2.60A1-335[»]
6PKZX-ray2.74A1-335[»]
6UOKX-ray2.55A/F1-335[»]
6UOLX-ray1.94A1-335[»]
6UOMX-ray2.05A1-335[»]
6W2MX-ray2.00A1-335[»]
7ICEX-ray2.80A1-335[»]
7ICFX-ray3.10A1-335[»]
7ICGX-ray3.00A1-335[»]
7ICHX-ray2.90A1-335[»]
7ICIX-ray2.80A1-335[»]
7ICJX-ray3.50A1-335[»]
7ICKX-ray2.90A1-335[»]
7ICLX-ray3.10A1-335[»]
7ICMX-ray3.00A1-335[»]
7ICNX-ray2.80A1-335[»]
7ICOX-ray3.30A1-335[»]
7ICPX-ray3.00A1-335[»]
7ICQX-ray2.90A1-335[»]
7ICRX-ray3.00A1-335[»]
7ICSX-ray2.80A1-335[»]
7ICTX-ray2.80A1-335[»]
7ICUX-ray3.30A1-335[»]
7ICVX-ray2.80A1-335[»]
8ICAX-ray3.00A1-335[»]
8ICBX-ray3.10A1-335[»]
8ICCX-ray2.80A1-335[»]
8ICEX-ray3.20A1-335[»]
8ICFX-ray2.90A1-335[»]
8ICGX-ray3.30A1-335[»]
8ICHX-ray3.30A1-335[»]
8ICIX-ray2.80A1-335[»]
8ICJX-ray3.20A1-335[»]
8ICKX-ray2.70A1-335[»]
8ICLX-ray3.10A1-335[»]
8ICMX-ray2.90A1-335[»]
8ICNX-ray2.80A1-335[»]
8ICOX-ray2.70A1-335[»]
8ICPX-ray2.90A1-335[»]
8ICQX-ray3.00A1-335[»]
8ICRX-ray2.90A1-335[»]
8ICSX-ray2.90A1-335[»]
8ICTX-ray3.10A1-335[»]
8ICUX-ray3.00A1-335[»]
8ICVX-ray3.20A1-335[»]
8ICWX-ray3.30A1-335[»]
8ICXX-ray3.00A1-335[»]
8ICYX-ray3.10A1-335[»]
8ICZX-ray3.10A1-335[»]
9ICAX-ray3.00A1-335[»]
9ICBX-ray3.20A1-335[»]
9ICCX-ray3.10A1-335[»]
9ICEX-ray3.30A1-335[»]
9ICFX-ray3.00A1-335[»]
9ICGX-ray3.00A1-335[»]
9ICHX-ray2.90A1-335[»]
9ICIX-ray3.10A1-335[»]
9ICJX-ray3.10A1-335[»]
9ICKX-ray2.70A1-335[»]
9ICLX-ray2.80A1-335[»]
9ICMX-ray2.90A1-335[»]
9ICNX-ray3.00A1-335[»]
9ICOX-ray2.90A1-335[»]
9ICPX-ray3.10A1-335[»]
9ICQX-ray2.90A1-335[»]
9ICRX-ray3.00A1-335[»]
9ICSX-ray2.90A1-335[»]
9ICTX-ray3.00A1-335[»]
9ICUX-ray2.90A1-335[»]
9ICVX-ray2.70A1-335[»]
9ICWX-ray2.60A1-335[»]
9ICXX-ray2.60A1-335[»]
9ICYX-ray3.00A1-335[»]
BMRBiP06746
SMRiP06746
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111419, 46 interactors
CORUMiP06746
IntActiP06746, 32 interactors
STRINGi9606.ENSP00000265421

Chemistry databases

BindingDBiP06746
ChEMBLiCHEMBL2392
DrugBankiDB07479, (1S)-1,2,3,4-TETRAHYDRO-BENZO[C]PHENANTHRENE-2,3,4-TRIOL
DB00987, Cytarabine
DB03222, dATP
DB14490, Ferrous ascorbate
DB14491, Ferrous fumarate
DB14488, Ferrous gluconate
DB14501, Ferrous glycine sulfate
DB14489, Ferrous succinate
DB01592, Iron
DrugCentraliP06746

PTM databases

iPTMnetiP06746
PhosphoSitePlusiP06746

Polymorphism and mutation databases

BioMutaiPOLB
DMDMi544186

Proteomic databases

EPDiP06746
jPOSTiP06746
MassIVEiP06746
MaxQBiP06746
PaxDbiP06746
PeptideAtlasiP06746
PRIDEiP06746
ProteomicsDBi51926

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3175, 388 antibodies

The DNASU plasmid repository

More...DNASUi		5423

Genome annotation databases

EnsembliENST00000265421; ENSP00000265421; ENSG00000070501
GeneIDi5423
KEGGihsa:5423
UCSCiuc003xoz.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5423
DisGeNETi5423
EuPathDBiHostDB:ENSG00000070501.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		POLB
HGNCiHGNC:9174, POLB
HPAiENSG00000070501, Tissue enhanced (brain)
MIMi174760, gene
neXtProtiNX_P06746
OpenTargetsiENSG00000070501
PharmGKBiPA276

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2534, Eukaryota
GeneTreeiENSGT00940000156918
HOGENOMiCLU_008698_1_0_1
InParanoidiP06746
KOiK02330
OMAiITDMLME
OrthoDBi1328151at2759
PhylomeDBiP06746
TreeFamiTF103002

Enzyme and pathway databases

BRENDAi2.7.7.7, 2681
4.2.99.B1, 2681
PathwayCommonsiP06746
ReactomeiR-HSA-110362, POLB-Dependent Long Patch Base Excision Repair
R-HSA-110373, Resolution of AP sites via the multiple-nucleotide patch replacement pathway
R-HSA-110381, Resolution of AP sites via the single-nucleotide replacement pathway
R-HSA-5649702, APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
R-HSA-5651801, PCNA-Dependent Long Patch Base Excision Repair
R-HSA-5689880, Ub-specific processing proteases
R-HSA-73930, Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
SIGNORiP06746

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5423, 5 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		POLB, human
EvolutionaryTraceiP06746

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DNA_polymerase_beta

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5423
PharosiP06746, Tchem

Protein Ontology

More...PROi		PR:P06746
RNActiP06746, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000070501, Expressed in cerebellar hemisphere and 236 other tissues
ExpressionAtlasiP06746, baseline and differential
GenevisibleiP06746, HS

Family and domain databases

CDDicd00141, NT_POLXc, 1 hit
Gene3Di1.10.150.110, 1 hit
3.30.210.10, 1 hit
3.30.460.10, 1 hit
InterProiView protein in InterPro
IPR002054, DNA-dir_DNA_pol_X
IPR019843, DNA_pol-X_BS
IPR010996, DNA_pol_b-like_N
IPR028207, DNA_pol_B_palm_palm
IPR018944, DNA_pol_lambd_fingers_domain
IPR027421, DNA_pol_lamdba_lyase_dom_sf
IPR037160, DNA_Pol_thumb_sf
IPR022312, DNA_pol_X
IPR002008, DNA_pol_X_beta-like
IPR003583, Hlx-hairpin-Hlx_DNA-bd_motif
IPR043519, NT_sf
IPR029398, PolB_thumb
PfamiView protein in Pfam
PF14792, DNA_pol_B_palm, 1 hit
PF14791, DNA_pol_B_thumb, 1 hit
PF10391, DNA_pol_lambd_f, 1 hit
PF14716, HHH_8, 1 hit
PRINTSiPR00869, DNAPOLX
PR00870, DNAPOLXBETA
SMARTiView protein in SMART
SM00278, HhH1, 2 hits
SM00483, POLXc, 1 hit
SUPFAMiSSF47802, SSF47802, 1 hit
SSF81301, SSF81301, 1 hit
PROSITEiView protein in PROSITE
PS00522, DNA_POLYMERASE_X, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDPOLB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06746
Secondary accession number(s): B2RC78, Q3KP48, Q6FI34
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: October 7, 2020
This is version 235 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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