Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myosin light chain alkali

Gene

Mlc1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • microfilament motor activity Source: UniProtKB

GO - Biological processi

  • mesoderm development Source: FlyBase
  • muscle contraction Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein, Muscle protein, Myosin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-445355 Smooth Muscle Contraction
R-DME-5627123 RHO GTPases activate PAKs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myosin light chain alkali
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mlc1
Synonyms:MLC-ALK
ORF Names:CG5596
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0002772 Mlc1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001987091 – 155Myosin light chain alkaliAdd BLAST155

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P06742

PRoteomics IDEntifications database

More...
PRIDEi
P06742

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Indirect flight muscle isoform is found only in the indirect flight muscles. The larval and adult isoform is present in the larval and adult musculature.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during late embryogenesis, larval instars, late stages of pupariation and adult.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0002772 Expressed in 31 organ(s), highest expression level in head

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P06742 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P06742 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
68205, 47 interactors

Database of interacting proteins

More...
DIPi
DIP-23903N

Protein interaction database and analysis system

More...
IntActi
P06742, 20 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0084565

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1155
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P06742

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P06742

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 41EF-hand 1PROSITE-ProRule annotationAdd BLAST35
Domaini80 – 115EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410ISFW Eukaryota
ENOG4111WV2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153671

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P06742

Identification of Orthologs from Complete Genome Data

More...
OMAi
CMDPEDE

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0TQL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P06742

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR029655 Mlc1

The PANTHER Classification System

More...
PANTHERi
PTHR23048:SF12 PTHR23048:SF12, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222 EF_HAND_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform Larval-adult (identifier: P06742-1) [UniParc]FASTAAdd to basket
Also known as: Larval-non-IFM

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADVPKREVE NVEFVFEVMG SPGEGIDAVD LGDALRALNL NPTLALIEKL
60 70 80 90 100
GGTKKRNEKK IKLDEFLPIY SQVKKEKEQG CYEDFIECLK LYDKEENGTM
110 120 130 140 150
LLAELQHALL ALGESLDDEQ VETLFADCMD PEDDEGFIPY SQFVQRLMSD

PVVFD
Length:155
Mass (Da):17,524
Last modified:January 27, 2003 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i65C92CD17995ECF5
GO
Isoform Indirect flight muscle (identifier: P06742-2) [UniParc]FASTAAdd to basket
Also known as: Pupa, Adult flight muscle

The sequence of this isoform differs from the canonical sequence as follows:
     142-155: QFVQRLMSDPVVFD → PFLARMCDRPDQLK

Show »
Length:155
Mass (Da):17,533
Checksum:i5B12DC95EB8A16ED
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4LHS1A0A0B4LHS1_DROME
Myosin alkali light chain 1, isofor...
Mlc1 chr3R:23484557..23484663, Dmel\CG5596, DmMLC1, ELC, ELC2
155Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2A → V (PubMed:2982157).Curated1
Sequence conflicti67L → M in AAA53454 (PubMed:7535717).Curated1
Sequence conflicti67L → M in AAA53458 (PubMed:7535717).Curated1
Sequence conflicti67L → M in AAA53460 (PubMed:7535717).Curated1
Sequence conflicti67L → M in AAA53466 (PubMed:7535717).Curated1
Sequence conflicti67L → M in AAA53468 (PubMed:7535717).Curated1
Sequence conflicti150D → H (PubMed:2982157).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003367142 – 155QFVQR…PVVFD → PFLARMCDRPDQLK in isoform Indirect flight muscle. CuratedAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M10125 Genomic DNA Translation: AAA28711.1
M10125 Genomic DNA Translation: AAA28712.1
K01567 mRNA Translation: AAA28710.1
AE014297 Genomic DNA Translation: AAF56733.2
AE014297 Genomic DNA Translation: AAN14121.1
AY070972 mRNA Translation: AAL48594.1
L37312 Genomic DNA Translation: AAA53441.1
L37312 Genomic DNA Translation: AAA53442.1
L37313 Genomic DNA Translation: AAA53443.1
L37313 Genomic DNA Translation: AAA53444.1
L37314 Genomic DNA Translation: AAA53445.1
L37314 Genomic DNA Translation: AAA53446.1
L37315 Genomic DNA Translation: AAA53447.1 Sequence problems.
L37315 Genomic DNA Translation: AAA53448.1 Sequence problems.
L37316 Genomic DNA Translation: AAA56798.1
L37316 Genomic DNA Translation: AAA56799.1 Sequence problems.
L37317 Genomic DNA Translation: AAA53449.1
L37317 Genomic DNA Translation: AAA53450.1
L37318 Genomic DNA Translation: AAA53451.1
L37318 Genomic DNA Translation: AAA53452.1
L37319 Genomic DNA Translation: AAA53453.1
L37319 Genomic DNA Translation: AAA53454.1
L37320 Genomic DNA Translation: AAA53455.1
L37320 Genomic DNA Translation: AAA53456.1
L37321 Genomic DNA Translation: AAA53457.1
L37321 Genomic DNA Translation: AAA53458.1
L37322 Genomic DNA Translation: AAA53459.1
L37322 Genomic DNA Translation: AAA53460.1
L37323 Genomic DNA Translation: AAA53461.1
L37323 Genomic DNA Translation: AAA53462.1
L37324 Genomic DNA Translation: AAA53463.1
L37324 Genomic DNA Translation: AAA53464.1
L37325 Genomic DNA Translation: AAA53465.1
L37325 Genomic DNA Translation: AAA53466.1
L37326 Genomic DNA Translation: AAA53467.1
L37326 Genomic DNA Translation: AAA53468.1
L37327 Genomic DNA Translation: AAA53469.1
L37327 Genomic DNA Translation: AAA53470.1

NCBI Reference Sequences

More...
RefSeqi
NP_001287569.1, NM_001300640.1 [P06742-1]
NP_476639.1, NM_057291.4 [P06742-2]
NP_476640.1, NM_057292.4 [P06742-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dm.6719

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0085195; FBpp0084565; FBgn0002772 [P06742-2]
FBtr0085196; FBpp0084566; FBgn0002772 [P06742-1]
FBtr0344131; FBpp0310544; FBgn0002772 [P06742-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
43323

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG5596

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M10125 Genomic DNA Translation: AAA28711.1
M10125 Genomic DNA Translation: AAA28712.1
K01567 mRNA Translation: AAA28710.1
AE014297 Genomic DNA Translation: AAF56733.2
AE014297 Genomic DNA Translation: AAN14121.1
AY070972 mRNA Translation: AAL48594.1
L37312 Genomic DNA Translation: AAA53441.1
L37312 Genomic DNA Translation: AAA53442.1
L37313 Genomic DNA Translation: AAA53443.1
L37313 Genomic DNA Translation: AAA53444.1
L37314 Genomic DNA Translation: AAA53445.1
L37314 Genomic DNA Translation: AAA53446.1
L37315 Genomic DNA Translation: AAA53447.1 Sequence problems.
L37315 Genomic DNA Translation: AAA53448.1 Sequence problems.
L37316 Genomic DNA Translation: AAA56798.1
L37316 Genomic DNA Translation: AAA56799.1 Sequence problems.
L37317 Genomic DNA Translation: AAA53449.1
L37317 Genomic DNA Translation: AAA53450.1
L37318 Genomic DNA Translation: AAA53451.1
L37318 Genomic DNA Translation: AAA53452.1
L37319 Genomic DNA Translation: AAA53453.1
L37319 Genomic DNA Translation: AAA53454.1
L37320 Genomic DNA Translation: AAA53455.1
L37320 Genomic DNA Translation: AAA53456.1
L37321 Genomic DNA Translation: AAA53457.1
L37321 Genomic DNA Translation: AAA53458.1
L37322 Genomic DNA Translation: AAA53459.1
L37322 Genomic DNA Translation: AAA53460.1
L37323 Genomic DNA Translation: AAA53461.1
L37323 Genomic DNA Translation: AAA53462.1
L37324 Genomic DNA Translation: AAA53463.1
L37324 Genomic DNA Translation: AAA53464.1
L37325 Genomic DNA Translation: AAA53465.1
L37325 Genomic DNA Translation: AAA53466.1
L37326 Genomic DNA Translation: AAA53467.1
L37326 Genomic DNA Translation: AAA53468.1
L37327 Genomic DNA Translation: AAA53469.1
L37327 Genomic DNA Translation: AAA53470.1
RefSeqiNP_001287569.1, NM_001300640.1 [P06742-1]
NP_476639.1, NM_057291.4 [P06742-2]
NP_476640.1, NM_057292.4 [P06742-1]
UniGeneiDm.6719

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5W1AX-ray2.23B/D1-151[»]
ProteinModelPortaliP06742
SMRiP06742
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi68205, 47 interactors
DIPiDIP-23903N
IntActiP06742, 20 interactors
STRINGi7227.FBpp0084565

Proteomic databases

PaxDbiP06742
PRIDEiP06742

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085195; FBpp0084565; FBgn0002772 [P06742-2]
FBtr0085196; FBpp0084566; FBgn0002772 [P06742-1]
FBtr0344131; FBpp0310544; FBgn0002772 [P06742-1]
GeneIDi43323
KEGGidme:Dmel_CG5596

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23209
FlyBaseiFBgn0002772 Mlc1

Phylogenomic databases

eggNOGiENOG410ISFW Eukaryota
ENOG4111WV2 LUCA
GeneTreeiENSGT00940000153671
InParanoidiP06742
OMAiCMDPEDE
OrthoDBiEOG091G0TQL
PhylomeDBiP06742

Enzyme and pathway databases

ReactomeiR-DME-445355 Smooth Muscle Contraction
R-DME-5627123 RHO GTPases activate PAKs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Mlc1 fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
43323

Protein Ontology

More...
PROi
PR:P06742

Gene expression databases

BgeeiFBgn0002772 Expressed in 31 organ(s), highest expression level in head
ExpressionAtlasiP06742 differential
GenevisibleiP06742 DM

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR029655 Mlc1
PANTHERiPTHR23048:SF12 PTHR23048:SF12, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMLC1_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06742
Secondary accession number(s): P06743
, P92155, P92156, P92157, P92183, P92187, P92196, Q24380, Q24381, Q24382, Q24383, Q27304, Q27315, Q27381, Q27414, Q94988, Q9VB12
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 27, 2003
Last modified: December 5, 2018
This is version 171 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again