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UniProtKB - P06737 (PYGL_HUMAN)

Entry version 225 (16 Oct 2019)
Sequence version 4 (23 Jan 2007)
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Protein

Glycogen phosphorylase, liver form

Gene

PYGL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphate

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activity of phosphorylase is controlled both by allosteric means (through the noncovalent binding of metabolites) and by covalent modification. Thus AMP allosterically activates, whereas ATP, ADP, and glucose-6-phosphate allosterically inhibit, phosphorylase B.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei76AMPBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei109Involved in the association of subunitsBy similarity1
Sitei143Involved in the association of subunitsBy similarity1
Sitei156May be involved in allosteric controlBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAllosteric enzyme, Glycosyltransferase, Transferase
Biological processCarbohydrate metabolism, Glycogen metabolism
LigandNucleotide-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS02099-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.4.1.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6798695 Neutrophil degranulation
R-HSA-70221 Glycogen breakdown (glycogenolysis)

SIGNOR Signaling Network Open Resource

More...SIGNORi		P06737

Protein family/group databases

Carbohydrate-Active enZymes

More...CAZyi		GT35 Glycosyltransferase Family 35

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glycogen phosphorylase, liver form (EC:2.4.1.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PYGL
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9725 PYGL

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613741 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P06737

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Glycogen storage disease 6 (GSD6)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA metabolic disorder characterized by mild to moderate hypoglycemia, mild ketosis, growth retardation, and prominent hepatomegaly. Heart and skeletal muscle are not affected.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_007908339N → S in GSD6. 1 PublicationCorresponds to variant dbSNP:rs113993976EnsemblClinVar.1
Natural variantiVAR_007909377N → K in GSD6. 1 PublicationCorresponds to variant dbSNP:rs113993977EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Glycogen storage disease

Organism-specific databases

DisGeNET

More...DisGeNETi		5836

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		PYGL

MalaCards human disease database

More...MalaCardsi		PYGL
MIMi232700 phenotype

Open Targets

More...OpenTargetsi		ENSG00000100504

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		369 Glycogen storage disease due to liver glycogen phosphorylase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34068

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P06737

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2568

Drug and drug target database

More...DrugBanki		DB02320 1-N-Acetyl-Beta-D-Glucosamine
DB07396 1-{2-[3-(2-Chloro-4,5-difluoro-benzoyl)-ureido]-4-fluoro-phenyl}-piperidine-4-carboxylic acid
DB07395 4-[3-(2-Chloro-4,5-difluoro-benzoyl)ureido]-3-trifluoromethoxybenzoic acid
DB03288 5-Chloro-1h-Indole-2-Carboxylic Acid{[Cyclopentyl-(2-Hydroxy-Ethyl)-Carbamoyl]-Methyl}-Amide
DB07315 5-chloro-N-{4-[(1R)-1,2-dihydroxyethyl]phenyl}-1H-indole-2-carboxamide
DB00131 Adenosine phosphate
DB03496 Alvocidib
DB02379 Beta-D-Glucose
DB02089 CP-526423
DB03744 Cp403700, (S)-1-{2-[(5-Chloro-1h-Indole-2-Carbonyl)-Amino]-3-Phenyl-Propionyl}-Azetidine-3-Carboxylate
DB04522 Dexfosfoserine
DB07968 N-(2-CHLORO-4-FLUOROBENZOYL)-N'-(5-HYDROXY-2-METHOXYPHENYL)UREA
DB05044 PSN357
DB00114 Pyridoxal phosphate
DB08844 Uric acid

DrugCentral

More...DrugCentrali		P06737

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PYGL

Domain mapping of disease mutations (DMDM)

More...DMDMi		6648082

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001885242 – 847Glycogen phosphorylase, liver formAdd BLAST846

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei15Phosphoserine; by PHK; in form phosphorylase A1 Publication1
Modified residuei364N6-succinyllysineBy similarity1
Modified residuei524PhosphoserineBy similarity1
Modified residuei561PhosphoserineBy similarity1
Modified residuei639PhosphoserineCombined sources1
Modified residuei681N6-(pyridoxal phosphate)lysineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P06737

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P06737

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P06737

MaxQB - The MaxQuant DataBase

More...MaxQBi		P06737

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P06737

PeptideAtlas

More...PeptideAtlasi		P06737

PRoteomics IDEntifications database

More...PRIDEi		P06737

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		27652
51923 [P06737-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P06737

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P06737

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P06737

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100504 Expressed in 200 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P06737 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P06737 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA000962
HPA004119

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Dimers associate into a tetramer to form the enzymatically active phosphorylase A.

Interacts with PPP1R3B (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PYGBP112168EBI-2511865,EBI-1047231

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		111794, 55 interactors

Protein interaction database and analysis system

More...IntActi		P06737, 23 interactors

Molecular INTeraction database

More...MINTi		P06737

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000216392

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P06737

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1847
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P06737

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P06737

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycogen phosphorylase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2099 Eukaryota
COG0058 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183148

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P06737

KEGG Orthology (KO)

More...KOi		K00688

Identification of Orthologs from Complete Genome Data

More...OMAi		HCACSVA

Database of Orthologous Groups

More...OrthoDBi		243095at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P06737

TreeFam database of animal gene trees

More...TreeFami		TF300309

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011833 Glycg_phsphrylas
IPR000811 Glyco_trans_35
IPR035090 Pyridoxal_P_attach_site

The PANTHER Classification System

More...PANTHERi		PTHR11468 PTHR11468, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00343 Phosphorylase, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000460 Pprylas_GlgP, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR02093 P_ylase, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00102 PHOSPHORYLASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P06737-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAKPLTDQEK RRQISIRGIV GVENVAELKK SFNRHLHFTL VKDRNVATTR 
        60         70         80         90        100
DYYFALAHTV RDHLVGRWIR TQQHYYDKCP KRVYYLSLEF YMGRTLQNTM 
       110        120        130        140        150
INLGLQNACD EAIYQLGLDI EELEEIEEDA GLGNGGLGRL AACFLDSMAT 
       160        170        180        190        200
LGLAAYGYGI RYEYGIFNQK IRDGWQVEEA DDWLRYGNPW EKSRPEFMLP 
       210        220        230        240        250
VHFYGKVEHT NTGTKWIDTQ VVLALPYDTP VPGYMNNTVN TMRLWSARAP 
       260        270        280        290        300
NDFNLRDFNV GDYIQAVLDR NLAENISRVL YPNDNFFEGK ELRLKQEYFV 
       310        320        330        340        350
VAATLQDIIR RFKASKFGST RGAGTVFDAF PDQVAIQLND THPALAIPEL 
       360        370        380        390        400
MRIFVDIEKL PWSKAWELTQ KTFAYTNHTV LPEALERWPV DLVEKLLPRH 
       410        420        430        440        450
LEIIYEINQK HLDRIVALFP KDVDRLRRMS LIEEEGSKRI NMAHLCIVGS 
       460        470        480        490        500
HAVNGVAKIH SDIVKTKVFK DFSELEPDKF QNKTNGITPR RWLLLCNPGL 
       510        520        530        540        550
AELIAEKIGE DYVKDLSQLT KLHSFLGDDV FLRELAKVKQ ENKLKFSQFL 
       560        570        580        590        600
ETEYKVKINP SSMFDVQVKR IHEYKRQLLN CLHVITMYNR IKKDPKKLFV 
       610        620        630        640        650
PRTVIIGGKA APGYHMAKMI IKLITSVADV VNNDPMVGSK LKVIFLENYR 
       660        670        680        690        700
VSLAEKVIPA TDLSEQISTA GTEASGTGNM KFMLNGALTI GTMDGANVEM 
       710        720        730        740        750
AEEAGEENLF IFGMRIDDVA ALDKKGYEAK EYYEALPELK LVIDQIDNGF 
       760        770        780        790        800
FSPKQPDLFK DIINMLFYHD RFKVFADYEA YVKCQDKVSQ LYMNPKAWNT 
       810        820        830        840 
MVLKNIAASG KFSSDRTIKE YAQNIWNVEP SDLKISLSNE SNKVNGN
Length:847
Mass (Da):97,149
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74017E8125FB5735
GO
Isoform 2 (identifier: P06737-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     82-115: Missing.

Note: No experimental confirmation available.
Show »
Length:813
Mass (Da):93,134
Checksum:i40B7DB0528A64AAA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PK47E9PK47_HUMAN
Alpha-1,4 glucan phosphorylase
PYGL
819Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2 – 3AK → GE in AAA52577 (PubMed:2877458).Curated2
Sequence conflicti2 – 3AK → GE in AAC18079 (PubMed:9536091).Curated2
Sequence conflicti83V → E in AAA52577 (PubMed:2877458).Curated1
Sequence conflicti323A → Q in AAA52577 (PubMed:2877458).Curated1
Sequence conflicti344 – 345AL → RI in AAA52577 (PubMed:2877458).Curated2
Sequence conflicti369T → N in AAA52577 (PubMed:2877458).Curated1
Sequence conflicti369T → N in AAC18079 (PubMed:9536091).Curated1
Sequence conflicti570R → S in AAC17450 (Ref. 2) Curated1
Sequence conflicti683Missing in AAH09895 (PubMed:15489334).Curated1
Sequence conflicti715R → G in BAG62279 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_007907222V → I1 PublicationCorresponds to variant dbSNP:rs946616EnsemblClinVar.1
Natural variantiVAR_013095231V → E. Corresponds to variant dbSNP:rs1042195Ensembl.1
Natural variantiVAR_007908339N → S in GSD6. 1 PublicationCorresponds to variant dbSNP:rs113993976EnsemblClinVar.1
Natural variantiVAR_007909377N → K in GSD6. 1 PublicationCorresponds to variant dbSNP:rs113993977EnsemblClinVar.1
Natural variantiVAR_034425425R → P1 PublicationCorresponds to variant dbSNP:rs2228499Ensembl.1
Natural variantiVAR_034426698V → G. Corresponds to variant dbSNP:rs35831273Ensembl.1
Natural variantiVAR_013096715R → S. Corresponds to variant dbSNP:rs1042210Ensembl.1
Natural variantiVAR_034427806I → L. Corresponds to variant dbSNP:rs34313873EnsemblClinVar.1
Natural variantiVAR_069054845N → S1 PublicationCorresponds to variant dbSNP:rs78558135EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04533982 – 115Missing in isoform 2. 1 PublicationAdd BLAST34

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M14636 mRNA Translation: AAA52577.1
AF066858 mRNA Translation: AAC17450.1
AF046798
, AF046787, AF046788, AF046789, AF046790, AF046791, AF046792, AF046793, AF046794, AF046795, AF046796, AF046797 Genomic DNA Translation: AAC18079.1
AF046785 mRNA Translation: AAC23504.1
Y15233 mRNA Translation: CAA75517.1
AK300580 mRNA Translation: BAG62279.1
AL358334 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65685.1
BC009895 mRNA Translation: AAH09895.3
BC082229 mRNA Translation: AAH82229.2
BC095850 mRNA Translation: AAH95850.2
BC110791 mRNA Translation: AAI10792.2
M36807 mRNA Translation: AAA35906.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS32080.1 [P06737-1]
CCDS53894.1 [P06737-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A25518

NCBI Reference Sequences

More...RefSeqi		NP_001157412.1, NM_001163940.1 [P06737-2]
NP_002854.3, NM_002863.4 [P06737-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000216392; ENSP00000216392; ENSG00000100504 [P06737-1]
ENST00000544180; ENSP00000443787; ENSG00000100504 [P06737-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5836

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5836

UCSC genome browser

More...UCSCi		uc001wyu.4 human [P06737-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14636 mRNA Translation: AAA52577.1
AF066858 mRNA Translation: AAC17450.1
AF046798
, AF046787, AF046788, AF046789, AF046790, AF046791, AF046792, AF046793, AF046794, AF046795, AF046796, AF046797 Genomic DNA Translation: AAC18079.1
AF046785 mRNA Translation: AAC23504.1
Y15233 mRNA Translation: CAA75517.1
AK300580 mRNA Translation: BAG62279.1
AL358334 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65685.1
BC009895 mRNA Translation: AAH09895.3
BC082229 mRNA Translation: AAH82229.2
BC095850 mRNA Translation: AAH95850.2
BC110791 mRNA Translation: AAI10792.2
M36807 mRNA Translation: AAA35906.1
CCDSiCCDS32080.1 [P06737-1]
CCDS53894.1 [P06737-2]
PIRiA25518
RefSeqiNP_001157412.1, NM_001163940.1 [P06737-2]
NP_002854.3, NM_002863.4 [P06737-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EM6X-ray2.20A/B1-847[»]
1EXVX-ray2.40A/B1-847[»]
1FA9X-ray2.40A2-847[»]
1FC0X-ray2.40A/B2-847[»]
1L5QX-ray2.25A/B1-847[»]
1L5RX-ray2.10A/B1-847[»]
1L5SX-ray2.10A/B1-847[»]
1L7XX-ray2.30A/B1-847[»]
1XOIX-ray2.10A/B2-847[»]
2ATIX-ray1.90A/B2-847[»]
2QLLX-ray2.56A1-847[»]
2ZB2X-ray2.45A/B1-847[»]
3CEHX-ray2.80A/B24-832[»]
3CEJX-ray3.30A/B24-832[»]
3CEMX-ray2.47A/B24-832[»]
3DD1X-ray2.57A/B2-847[»]
3DDSX-ray1.80A/B2-847[»]
3DDWX-ray1.90A/B2-847[»]
SMRiP06737
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi111794, 55 interactors
IntActiP06737, 23 interactors
MINTiP06737
STRINGi9606.ENSP00000216392

Chemistry databases

BindingDBiP06737
ChEMBLiCHEMBL2568
DrugBankiDB02320 1-N-Acetyl-Beta-D-Glucosamine
DB07396 1-{2-[3-(2-Chloro-4,5-difluoro-benzoyl)-ureido]-4-fluoro-phenyl}-piperidine-4-carboxylic acid
DB07395 4-[3-(2-Chloro-4,5-difluoro-benzoyl)ureido]-3-trifluoromethoxybenzoic acid
DB03288 5-Chloro-1h-Indole-2-Carboxylic Acid{[Cyclopentyl-(2-Hydroxy-Ethyl)-Carbamoyl]-Methyl}-Amide
DB07315 5-chloro-N-{4-[(1R)-1,2-dihydroxyethyl]phenyl}-1H-indole-2-carboxamide
DB00131 Adenosine phosphate
DB03496 Alvocidib
DB02379 Beta-D-Glucose
DB02089 CP-526423
DB03744 Cp403700, (S)-1-{2-[(5-Chloro-1h-Indole-2-Carbonyl)-Amino]-3-Phenyl-Propionyl}-Azetidine-3-Carboxylate
DB04522 Dexfosfoserine
DB07968 N-(2-CHLORO-4-FLUOROBENZOYL)-N'-(5-HYDROXY-2-METHOXYPHENYL)UREA
DB05044 PSN357
DB00114 Pyridoxal phosphate
DB08844 Uric acid
DrugCentraliP06737

Protein family/group databases

CAZyiGT35 Glycosyltransferase Family 35

PTM databases

iPTMnetiP06737
PhosphoSitePlusiP06737
SwissPalmiP06737

Polymorphism and mutation databases

BioMutaiPYGL
DMDMi6648082

Proteomic databases

EPDiP06737
jPOSTiP06737
MassIVEiP06737
MaxQBiP06737
PaxDbiP06737
PeptideAtlasiP06737
PRIDEiP06737
ProteomicsDBi27652
51923 [P06737-1]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		5836

Genome annotation databases

EnsembliENST00000216392; ENSP00000216392; ENSG00000100504 [P06737-1]
ENST00000544180; ENSP00000443787; ENSG00000100504 [P06737-2]
GeneIDi5836
KEGGihsa:5836
UCSCiuc001wyu.4 human [P06737-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5836
DisGeNETi5836

GeneCards: human genes, protein and diseases

More...GeneCardsi		PYGL
GeneReviewsiPYGL
HGNCiHGNC:9725 PYGL
HPAiHPA000962
HPA004119
MalaCardsiPYGL
MIMi232700 phenotype
613741 gene
neXtProtiNX_P06737
OpenTargetsiENSG00000100504
Orphaneti369 Glycogen storage disease due to liver glycogen phosphorylase deficiency
PharmGKBiPA34068

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2099 Eukaryota
COG0058 LUCA
GeneTreeiENSGT00950000183148
InParanoidiP06737
KOiK00688
OMAiHCACSVA
OrthoDBi243095at2759
PhylomeDBiP06737
TreeFamiTF300309

Enzyme and pathway databases

BioCyciMetaCyc:HS02099-MONOMER
BRENDAi2.4.1.1 2681
ReactomeiR-HSA-6798695 Neutrophil degranulation
R-HSA-70221 Glycogen breakdown (glycogenolysis)
SIGNORiP06737

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PYGL human
EvolutionaryTraceiP06737

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5836
PharosiP06737

Protein Ontology

More...PROi		PR:P06737

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000100504 Expressed in 200 organ(s), highest expression level in blood
ExpressionAtlasiP06737 baseline and differential
GenevisibleiP06737 HS

Family and domain databases

InterProiView protein in InterPro
IPR011833 Glycg_phsphrylas
IPR000811 Glyco_trans_35
IPR035090 Pyridoxal_P_attach_site
PANTHERiPTHR11468 PTHR11468, 1 hit
PfamiView protein in Pfam
PF00343 Phosphorylase, 1 hit
PIRSFiPIRSF000460 Pprylas_GlgP, 1 hit
TIGRFAMsiTIGR02093 P_ylase, 1 hit
PROSITEiView protein in PROSITE
PS00102 PHOSPHORYLASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPYGL_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06737
Secondary accession number(s): A6NDQ4
, B4DUB7, F5H816, O60567, O60752, O60913, Q501V9, Q641R5, Q96G82
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 225 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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