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Protein

Low affinity immunoglobulin epsilon Fc receptor

Gene

FCER2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Miscellaneous

There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi249Calcium1 Publication1
Metal bindingi251Calcium1 Publication1
Metal bindingi269Calcium1 Publication1
Metal bindingi270Calcium1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • IgE binding Source: UniProtKB-KW
  • integrin binding Source: ProtInc
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIgE-binding protein, Receptor
LigandCalcium, Lectin, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2197563 NOTCH2 intracellular domain regulates transcription
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P06734

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Low affinity immunoglobulin epsilon Fc receptor
Alternative name(s):
BLAST-2
C-type lectin domain family 4 member J
Fc-epsilon-RII
Immunoglobulin E-binding factor
Lymphocyte IgE receptor
CD_antigen: CD23
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FCER2
Synonyms:CD23A, CLEC4J, FCE2, IGEBF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000104921.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3612 FCER2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
151445 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P06734

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei22 – 47Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST26
Topological domaini48 – 321ExtracellularSequence analysisAdd BLAST274

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2208

Open Targets

More...
OpenTargetsi
ENSG00000104921

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28058

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2940

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2935

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FCER2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
119862

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000173911 – 321Low affinity immunoglobulin epsilon Fc receptor membrane-bound formAdd BLAST321
ChainiPRO_0000017392150 – 321Low affinity immunoglobulin epsilon Fc receptor soluble formAdd BLAST172

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi17S-palmitoyl cysteine1 Publication1
Lipidationi18S-palmitoyl cysteine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi63N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi160 ↔ 288
Disulfide bondi163 ↔ 174
Disulfide bondi191 ↔ 282
Disulfide bondi259 ↔ 273

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N- and O-glycosylated.
The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei149 – 150Cleavage2

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P06734

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P06734

PeptideAtlas

More...
PeptideAtlasi
P06734

PRoteomics IDEntifications database

More...
PRIDEi
P06734

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51921

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P06734

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P06734

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P06734

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104921 Expressed in 98 organ(s), highest expression level in adrenal gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_FCER2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P06734 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P06734 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002624
HPA008928

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ATF7P175443EBI-10199985,EBI-765623

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108502, 4 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P06734

Protein interaction database and analysis system

More...
IntActi
P06734, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000264072

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P06734

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1321
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HLImodel-A173-285[»]
1KJEmodel-A173-285[»]
1T8CNMR-A156-298[»]
1T8DNMR-A156-298[»]
2H2RX-ray1.50A/B150-321[»]
2H2TX-ray1.30B150-321[»]
4EZMX-ray3.10G/H/I/J/K/L156-298[»]
4G96X-ray2.25A/B/C/D156-298[»]
4G9AX-ray2.00A/B/C/D156-298[»]
4GI0X-ray2.27A/B/C156-298[»]
4GJ0X-ray1.95A/B/C/D156-298[»]
4GJXX-ray2.80A/B/C/D/E/F/G/H156-298[»]
4GK1X-ray2.24A/B/C/D/E/F/G156-298[»]
4GKOX-ray3.30G/H/I/J/K/L156-298[»]
4J6JX-ray1.90A/B/C/D156-298[»]
4J6KX-ray2.30A/B/C/D/E/F/G/H156-298[»]
4J6LX-ray3.15A/B/C/D/E/F/G/H156-298[»]
4J6MX-ray2.48A/B/C/D/E/F/G/H156-298[»]
4J6NX-ray2.85A/B156-298[»]
4J6PX-ray1.90A/B/C/D156-298[»]
4J6QX-ray2.54A156-298[»]
4KI1X-ray3.20E/F/G/H156-298[»]
5LGKX-ray3.50E/F165-284[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P06734

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P06734

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P06734

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati69 – 89Add BLAST21
Repeati90 – 110Add BLAST21
Repeati111 – 131Add BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini162 – 284C-type lectinPROSITE-ProRule annotationAdd BLAST123

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4297 Eukaryota
ENOG410XPJ1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162574

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000089951

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG051599

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P06734

KEGG Orthology (KO)

More...
KOi
K06468

Identification of Orthologs from Complete Genome Data

More...
OMAi
WNDAFCG

Database of Orthologous Groups

More...
OrthoDBi
985894at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P06734

TreeFam database of animal gene trees

More...
TreeFami
TF333341

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03590 CLECT_DC-SIGN_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00059 Lectin_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034 CLECT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56436 SSF56436, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P06734-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEGQYSEIE ELPRRRCCRR GTQIVLLGLV TAALWAGLLT LLLLWHWDTT
60 70 80 90 100
QSLKQLEERA ARNVSQVSKN LESHHGDQMA QKSQSTQISQ ELEELRAEQQ
110 120 130 140 150
RLKSQDLELS WNLNGLQADL SSFKSQELNE RNEASDLLER LREEVTKLRM
160 170 180 190 200
ELQVSSGFVC NTCPEKWINF QRKCYYFGKG TKQWVHARYA CDDMEGQLVS
210 220 230 240 250
IHSPEEQDFL TKHASHTGSW IGLRNLDLKG EFIWVDGSHV DYSNWAPGEP
260 270 280 290 300
TSRSQGEDCV MMRGSGRWND AFCDRKLGAW VCDRLATCTP PASEGSAESM
310 320
GPDSRPDPDG RLPTPSAPLH S
Length:321
Mass (Da):36,469
Last modified:January 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF86708C0E6515B87
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K3W4U1K3W4U1_HUMAN
Low affinity immunoglobulin epsilon...
FCER2
320Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R1R5M0R1R5_HUMAN
Low affinity immunoglobulin epsilon...
FCER2
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA52433 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti269N → T in CAA28465 (PubMed:3034567).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03538762R → W. Corresponds to variant dbSNP:rs2228137Ensembl.1
Natural variantiVAR_035388284R → Q. Corresponds to variant dbSNP:rs8102872Ensembl.1
Natural variantiVAR_069800316S → F1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M15059 mRNA Translation: AAA52434.1
M14766 mRNA Translation: AAA52435.1
X04772 mRNA Translation: CAA28465.1
AC008763 Genomic DNA No translation available.
BC014108 mRNA Translation: AAH14108.1
BC062591 mRNA Translation: AAH62591.1
M23562 Genomic DNA Translation: AAA52433.1 Sequence problems.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12184.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A26067 LNHUER

NCBI Reference Sequences

More...
RefSeqi
NP_001193948.2, NM_001207019.2
NP_001207429.1, NM_001220500.1
NP_001993.2, NM_002002.4
XP_005272519.1, XM_005272462.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.465778

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000346664; ENSP00000264072; ENSG00000104921
ENST00000597921; ENSP00000471974; ENSG00000104921

Database of genes from NCBI RefSeq genomes

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GeneIDi
2208

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2208

UCSC genome browser

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UCSCi
uc002mhm.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

CD23

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15059 mRNA Translation: AAA52434.1
M14766 mRNA Translation: AAA52435.1
X04772 mRNA Translation: CAA28465.1
AC008763 Genomic DNA No translation available.
BC014108 mRNA Translation: AAH14108.1
BC062591 mRNA Translation: AAH62591.1
M23562 Genomic DNA Translation: AAA52433.1 Sequence problems.
CCDSiCCDS12184.1
PIRiA26067 LNHUER
RefSeqiNP_001193948.2, NM_001207019.2
NP_001207429.1, NM_001220500.1
NP_001993.2, NM_002002.4
XP_005272519.1, XM_005272462.4
UniGeneiHs.465778

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HLImodel-A173-285[»]
1KJEmodel-A173-285[»]
1T8CNMR-A156-298[»]
1T8DNMR-A156-298[»]
2H2RX-ray1.50A/B150-321[»]
2H2TX-ray1.30B150-321[»]
4EZMX-ray3.10G/H/I/J/K/L156-298[»]
4G96X-ray2.25A/B/C/D156-298[»]
4G9AX-ray2.00A/B/C/D156-298[»]
4GI0X-ray2.27A/B/C156-298[»]
4GJ0X-ray1.95A/B/C/D156-298[»]
4GJXX-ray2.80A/B/C/D/E/F/G/H156-298[»]
4GK1X-ray2.24A/B/C/D/E/F/G156-298[»]
4GKOX-ray3.30G/H/I/J/K/L156-298[»]
4J6JX-ray1.90A/B/C/D156-298[»]
4J6KX-ray2.30A/B/C/D/E/F/G/H156-298[»]
4J6LX-ray3.15A/B/C/D/E/F/G/H156-298[»]
4J6MX-ray2.48A/B/C/D/E/F/G/H156-298[»]
4J6NX-ray2.85A/B156-298[»]
4J6PX-ray1.90A/B/C/D156-298[»]
4J6QX-ray2.54A156-298[»]
4KI1X-ray3.20E/F/G/H156-298[»]
5LGKX-ray3.50E/F165-284[»]
ProteinModelPortaliP06734
SMRiP06734
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108502, 4 interactors
CORUMiP06734
IntActiP06734, 1 interactor
STRINGi9606.ENSP00000264072

Chemistry databases

BindingDBiP06734
ChEMBLiCHEMBL2940
GuidetoPHARMACOLOGYi2935

PTM databases

PhosphoSitePlusiP06734
SwissPalmiP06734

Polymorphism and mutation databases

BioMutaiFCER2
DMDMi119862

Proteomic databases

MaxQBiP06734
PaxDbiP06734
PeptideAtlasiP06734
PRIDEiP06734
ProteomicsDBi51921

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
2208
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346664; ENSP00000264072; ENSG00000104921
ENST00000597921; ENSP00000471974; ENSG00000104921
GeneIDi2208
KEGGihsa:2208
UCSCiuc002mhm.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2208
DisGeNETi2208
EuPathDBiHostDB:ENSG00000104921.14

GeneCards: human genes, protein and diseases

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GeneCardsi
FCER2
HGNCiHGNC:3612 FCER2
HPAiCAB002624
HPA008928
MIMi151445 gene
neXtProtiNX_P06734
OpenTargetsiENSG00000104921
PharmGKBiPA28058

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00940000162574
HOGENOMiHOG000089951
HOVERGENiHBG051599
InParanoidiP06734
KOiK06468
OMAiWNDAFCG
OrthoDBi985894at2759
PhylomeDBiP06734
TreeFamiTF333341

Enzyme and pathway databases

ReactomeiR-HSA-2197563 NOTCH2 intracellular domain regulates transcription
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SIGNORiP06734

Miscellaneous databases

EvolutionaryTraceiP06734

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CD23

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2208
PMAP-CutDBiP06734

Protein Ontology

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PROi
PR:P06734

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000104921 Expressed in 98 organ(s), highest expression level in adrenal gland
CleanExiHS_FCER2
ExpressionAtlasiP06734 baseline and differential
GenevisibleiP06734 HS

Family and domain databases

CDDicd03590 CLECT_DC-SIGN_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR033989 CD209-like_CTLD
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFCER2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06734
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: January 16, 2019
This is version 197 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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