UniProtKB - P06733 (ENOA_HUMAN)
Alpha-enolase
ENO1
Functioni
Miscellaneous
Catalytic activityi
- EC:4.2.1.112 Publications
Cofactori
pH dependencei
: glycolysis Pathwayi
This protein is involved in step 4 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.1 PublicationProteins known to be involved in the 5 steps of the subpathway in this organism are:
- Glyceraldehyde-3-phosphate dehydrogenase (HEL-S-278), Glyceraldehyde-3-phosphate dehydrogenase, Glyceraldehyde-3-phosphate dehydrogenase (HEL-S-162eP), Glyceraldehyde-3-phosphate dehydrogenase, testis-specific (GAPDHS), Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
- Phosphoglycerate kinase, Phosphoglycerate kinase 2 (PGK2), Phosphoglycerate kinase, Phosphoglycerate kinase, Phosphoglycerate kinase 1 (PGK1), Phosphoglycerate kinase (HEL-S-68p), Phosphoglycerate kinase (HEL-S-272), Phosphoglycerate kinase, Phosphoglycerate kinase, Phosphoglycerate kinase
- no protein annotated in this organism
- Beta-enolase (ENO3), Alpha-enolase (ENO1), 2-phospho-D-glycerate hydro-lyase, 2-phospho-D-glycerate hydro-lyase (ENO4), 2-phospho-D-glycerate hydro-lyase, 2-phospho-D-glycerate hydro-lyase (HEL-S-17), 2-phospho-D-glycerate hydro-lyase (ENO4), 2-phospho-D-glycerate hydro-lyase (ENO1), 2-phospho-D-glycerate hydro-lyase (ENO3), 2-phospho-D-glycerate hydro-lyase (ENO2), 2-phospho-D-glycerate hydro-lyase (ENO1), 2-phospho-D-glycerate hydro-lyase (ENO3), 2-phospho-D-glycerate hydro-lyase (ENO2), Enolase 4 (ENO4), 2-phospho-D-glycerate hydro-lyase (ENO1), 2-phospho-D-glycerate hydro-lyase (ENO3), 2-phospho-D-glycerate hydro-lyase (ENO1), 2-phospho-D-glycerate hydro-lyase, 2-phospho-D-glycerate hydro-lyase, 2-phospho-D-glycerate hydro-lyase, 2-phospho-D-glycerate hydro-lyase (ENO3), 2-phospho-D-glycerate hydro-lyase (ENO2), 2-phospho-D-glycerate hydro-lyase (ENO2), 2-phospho-D-glycerate hydro-lyase (EDARADD), Gamma-enolase (ENO2)
- Pyruvate kinase, Pyruvate kinase PKLR (PKLR), Pyruvate kinase, Pyruvate kinase, Pyruvate kinase PKM (PKM), Pyruvate kinase (PKM2), Pyruvate kinase (PKLR), Pyruvate kinase (PKM), Pyruvate kinase (PKM2), Pyruvate kinase (PKM), Pyruvate kinase (HEL-S-30), Pyruvate kinase (PKM), Pyruvate kinase (PKM), Pyruvate kinase (PKM), Pyruvate kinase (PKM), Pyruvate kinase (PKM2), Pyruvate kinase (PKM), Pyruvate kinase (PKLR), Pyruvate kinase (PKLR), Pyruvate kinase (PKM2), Pyruvate kinase, Pyruvate kinase (PKM)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 40 | Magnesium 11 Publication | 1 | |
Binding sitei | 158 | SubstrateBy similarity | 1 | |
Binding sitei | 167 | SubstrateBy similarity | 1 | |
Active sitei | 210 | Proton donorBy similarity | 1 | |
Metal bindingi | 245 | Magnesium 21 Publication | 1 | |
Metal bindingi | 293 | Magnesium 21 Publication | 1 | |
Binding sitei | 293 | SubstrateBy similarity | 1 | |
Metal bindingi | 318 | Magnesium 21 Publication | 1 | |
Binding sitei | 318 | SubstrateBy similarity | 1 | |
Active sitei | 343 | Proton acceptorBy similarity | 1 | |
Binding sitei | 394 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: CAFA
- GTPase binding Source: UniProtKB
- magnesium ion binding Source: InterPro
- phosphopyruvate hydratase activity Source: UniProtKB
- protein homodimerization activity Source: CAFA
- RNA binding Source: UniProtKB
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB
GO - Biological processi
- canonical glycolysis Source: UniProtKB
- gluconeogenesis Source: Reactome
- glycolytic process Source: GO_Central
- negative regulation of cell growth Source: UniProtKB
- negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway Source: CAFA
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: CAFA
- positive regulation of ATP biosynthetic process Source: CAFA
- positive regulation of muscle contraction Source: CAFA
- positive regulation of plasminogen activation Source: CAFA
- regulation of vacuole fusion, non-autophagic Source: GO_Central
- response to virus Source: UniProtKB
Keywordsi
Molecular function | DNA-binding, Lyase, Repressor |
Biological process | Glycolysis, Plasminogen activation, Transcription, Transcription regulation |
Ligand | Magnesium, Metal-binding |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000074800-MONOMER |
BRENDAi | 4.2.1.11, 2681 |
PathwayCommonsi | P06733 |
Reactomei | R-HSA-70171, Glycolysis R-HSA-70263, Gluconeogenesis R-HSA-9636667, Manipulation of host energy metabolism |
SABIO-RKi | P06733 |
SIGNORi | P06733 |
UniPathwayi | UPA00109;UER00187 |
Protein family/group databases
MoonDBi | P06733, Predicted |
MoonProti | P06733 |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-enolase (EC:4.2.1.112 Publications)Alternative name(s): 2-phospho-D-glycerate hydro-lyase C-myc promoter-binding protein Enolase 1 MBP-1 MPB-1 Non-neural enolase Short name: NNE Phosphopyruvate hydratase Plasminogen-binding protein |
Gene namesi | Name:ENO1 Synonyms:ENO1L1, MBPB1, MPB1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000074800.13 |
HGNCi | HGNC:3350, ENO1 |
MIMi | 172430, gene |
neXtProti | NX_P06733 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication
Other locations
Note: Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. ENO1 is localized to the M line.
Nucleus
Cytosol
- cytosol Source: CAFA
- phosphopyruvate hydratase complex Source: CAFA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular space Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: CAFA
Other locations
- cell cortex region Source: CAFA
- cell surface Source: CAFA
- cytoplasm Source: LIFEdb
- M band Source: UniProtKB-SubCell
- membrane Source: CAFA
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 94 | M → I: MBP1 protein production. No MBP1 protein production; when associated with I-97. 1 Publication | 1 | |
Mutagenesisi | 97 | M → I: MBP1 protein production. No MBP1 protein production; when associated with I-94. 1 Publication | 1 | |
Mutagenesisi | 281 | K → R: Decreased 2-hydroxyisobutyrylation leading to decreased phosphopyruvate hydratase activity. 1 Publication | 1 | |
Mutagenesisi | 384 | L → A: Loss of transcriptional repression and cell growth inhibition; when associated with A-388. 1 Publication | 1 | |
Mutagenesisi | 388 | L → A: Loss of transcriptional repression and cell growth inhibition; when associated with A-384. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 2023 |
OpenTargetsi | ENSG00000074800 |
PharmGKBi | PA27786 |
Miscellaneous databases
Pharosi | P06733, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3298 |
DrugBanki | DB11638, Artenimol DB09130, Copper DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Polymorphism and mutation databases
BioMutai | ENO1 |
DMDMi | 119339 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000134097 | 2 – 434 | Alpha-enolaseAdd BLAST | 433 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources1 Publication | 1 | |
Modified residuei | 5 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 27 | PhosphoserineCombined sources | 1 | |
Modified residuei | 44 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 60 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 60 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 64 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 71 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 89 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 89 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 92 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 126 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 193 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 199 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 202 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 202 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 228 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 228 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 228 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 233 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 233 | N6-malonyllysine; alternate1 Publication | 1 | |
Modified residuei | 254 | PhosphoserineCombined sources | 1 | |
Modified residuei | 256 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 263 | PhosphoserineCombined sources | 1 | |
Modified residuei | 272 | PhosphoserineCombined sources | 1 | |
Modified residuei | 281 | N6-(2-hydroxyisobutyryl)lysine; alternate1 Publication | 1 | |
Modified residuei | 281 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 285 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 287 | PhosphotyrosineCombined sources | 1 | |
Modified residuei | 291 | PhosphoserineCombined sources | 1 | |
Modified residuei | 335 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 343 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 406 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 420 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 420 | N6-malonyllysine; alternate1 Publication | 1 | |
Modified residuei | 420 | N6-succinyllysine; alternateBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Hydroxylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-70 |
EPDi | P06733 |
jPOSTi | P06733 |
MassIVEi | P06733 |
MaxQBi | P06733 |
PaxDbi | P06733 |
PeptideAtlasi | P06733 |
PRIDEi | P06733 |
ProteomicsDBi | 51919 [P06733-1] 51920 [P06733-2] |
TopDownProteomicsi | P06733-1 [P06733-1] P06733-2 [P06733-2] |
2D gel databases
DOSAC-COBS-2DPAGEi | P06733 |
OGPi | P06733 |
REPRODUCTION-2DPAGEi | IPI00465248 P06733 |
SWISS-2DPAGEi | P06733 |
UCD-2DPAGEi | P06733 |
PTM databases
GlyGeni | P06733, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P06733 |
MetOSitei | P06733 |
PhosphoSitePlusi | P06733 |
SwissPalmi | P06733 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | ENSG00000074800, Expressed in cortex of kidney and 243 other tissues |
ExpressionAtlasi | P06733, baseline and differential |
Genevisiblei | P06733, HS |
Organism-specific databases
HPAi | ENSG00000074800, Low tissue specificity |
Interactioni
Subunit structurei
Mammalian enolase is composed of 3 isozyme subunits, alpha, beta and gamma, which can form homodimers or heterodimers which are cell-type and development-specific (PubMed:18560153). ENO1 interacts with PLG in the neuronal plasma membrane and promotes its activation. The C-terminal lysine is required for this binding (PubMed:9308760). Isoform MBP-1 interacts with TRAPPC2B (PubMed:11134351).
Interacts with ENO4 and PGAM2 (By similarity).
Interacts with CMTM6 (PubMed:28813417).
By similarity4 PublicationsBinary interactionsi
Hide detailsP06733
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- GTPase binding Source: UniProtKB
- protein homodimerization activity Source: CAFA
Protein-protein interaction databases
BioGRIDi | 108338, 393 interactors |
IntActi | P06733, 121 interactors |
MINTi | P06733 |
STRINGi | 9606.ENSP00000234590 |
Chemistry databases
BindingDBi | P06733 |
Miscellaneous databases
RNActi | P06733, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P06733 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P06733 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 31 – 38 | Epitope recognized by CAR and healthy patient antibodies | 8 | |
Regioni | 56 – 63 | Epitope recognized by CAR antibodies | 8 | |
Regioni | 97 – 237 | Required for repression of c-myc promoter activityAdd BLAST | 141 | |
Regioni | 370 – 373 | Substrate bindingBy similarity | 4 | |
Regioni | 405 – 434 | Required for interaction with PLGBy similarityAdd BLAST | 30 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2670, Eukaryota |
GeneTreei | ENSGT00950000182805 |
HOGENOMi | CLU_031223_0_0_1 |
InParanoidi | P06733 |
OMAi | GPELVGY |
PhylomeDBi | P06733 |
TreeFami | TF300391 |
Family and domain databases
CDDi | cd03313, enolase, 1 hit |
Gene3Di | 3.20.20.120, 1 hit 3.30.390.10, 1 hit |
HAMAPi | MF_00318, Enolase, 1 hit |
InterProi | View protein in InterPro IPR000941, Enolase IPR036849, Enolase-like_C_sf IPR029017, Enolase-like_N IPR020810, Enolase_C IPR020809, Enolase_CS IPR020811, Enolase_N |
PANTHERi | PTHR11902, PTHR11902, 1 hit |
Pfami | View protein in Pfam PF00113, Enolase_C, 1 hit PF03952, Enolase_N, 1 hit |
PIRSFi | PIRSF001400, Enolase, 1 hit |
PRINTSi | PR00148, ENOLASE |
SFLDi | SFLDG00178, enolase, 1 hit |
SMARTi | View protein in SMART SM01192, Enolase_C, 1 hit SM01193, Enolase_N, 1 hit |
SUPFAMi | SSF51604, SSF51604, 1 hit SSF54826, SSF54826, 1 hit |
TIGRFAMsi | TIGR01060, eno, 1 hit |
PROSITEi | View protein in PROSITE PS00164, ENOLASE, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative initiation. AlignAdd to basketThis entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSILKIHARE IFDSRGNPTV EVDLFTSKGL FRAAVPSGAS TGIYEALELR
60 70 80 90 100
DNDKTRYMGK GVSKAVEHIN KTIAPALVSK KLNVTEQEKI DKLMIEMDGT
110 120 130 140 150
ENKSKFGANA ILGVSLAVCK AGAVEKGVPL YRHIADLAGN SEVILPVPAF
160 170 180 190 200
NVINGGSHAG NKLAMQEFMI LPVGAANFRE AMRIGAEVYH NLKNVIKEKY
210 220 230 240 250
GKDATNVGDE GGFAPNILEN KEGLELLKTA IGKAGYTDKV VIGMDVAASE
260 270 280 290 300
FFRSGKYDLD FKSPDDPSRY ISPDQLADLY KSFIKDYPVV SIEDPFDQDD
310 320 330 340 350
WGAWQKFTAS AGIQVVGDDL TVTNPKRIAK AVNEKSCNCL LLKVNQIGSV
360 370 380 390 400
TESLQACKLA QANGWGVMVS HRSGETEDTF IADLVVGLCT GQIKTGAPCR
410 420 430
SERLAKYNQL LRIEEELGSK AKFAGRNFRN PLAK
The sequence of this isoform differs from the canonical sequence as follows:
1-93: Missing.
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8Y6G6 | A0A2R8Y6G6_HUMAN | 2-phospho-D-glycerate hydro-lyase | ENO1 | 434 | Annotation score: | ||
K7EM90 | K7EM90_HUMAN | 2-phospho-D-glycerate hydro-lyase | ENO1 | 195 | Annotation score: | ||
A0A2R8YEM5 | A0A2R8YEM5_HUMAN | 2-phospho-D-glycerate hydro-lyase | ENO1 | 171 | Annotation score: | ||
A0A2R8Y879 | A0A2R8Y879_HUMAN | Alpha-enolase | ENO1 | 125 | Annotation score: | ||
K7ERS8 | K7ERS8_HUMAN | Alpha-enolase | ENO1 | 83 | Annotation score: | ||
A0A2R8Y798 | A0A2R8Y798_HUMAN | Alpha-enolase | ENO1 | 70 | Annotation score: | ||
A0A2R8YEG5 | A0A2R8YEG5_HUMAN | Alpha-enolase | ENO1 | 101 | Annotation score: | ||
A0A2R8Y6I8 | A0A2R8Y6I8_HUMAN | Alpha-enolase | ENO1 | 33 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 55 | T → A in CAD97642 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 78 | V → A in BAD96237 (Ref. 7) Curated | 1 | |
Sequence conflicti | 187 | E → G in CAD97642 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 199 | K → R in BAD96912 (Ref. 7) Curated | 1 | |
Sequence conflicti | 252 | F → S in CAA59331 (PubMed:8824716).Curated | 1 | |
Sequence conflicti | 310 | S → I in CAD97642 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_025172 | 177 | N → K1 PublicationCorresponds to variant dbSNP:rs11544513Ensembl. | 1 | |
Natural variantiVAR_048936 | 325 | P → Q. Corresponds to variant dbSNP:rs11544514Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018725 | 1 – 93 | Missing in isoform MBP-1. 1 PublicationAdd BLAST | 93 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14328 mRNA Translation: AAA52387.1 X16288, X16289, X16290 Genomic DNA Translation: CAA34360.1 M55914 mRNA Translation: AAA35698.1 Frameshift. X84907 mRNA Translation: CAA59331.1 BT007163 mRNA Translation: AAP35827.1 AK315417 mRNA Translation: BAG37806.1 AL833741 mRNA Translation: CAH56247.1 BX537400 mRNA Translation: CAD97642.1 AK222517 mRNA Translation: BAD96237.1 AK223192 mRNA Translation: BAD96912.1 DQ056744 Genomic DNA Translation: AAY43128.1 AL139415 Genomic DNA Translation: CAC42425.1 CH471130 Genomic DNA Translation: EAW71604.1 BC001810 mRNA Translation: AAH01810.1 BC004325 mRNA Translation: AAH04325.1 BC004458 mRNA Translation: AAH04458.1 BC009218 mRNA Translation: AAH09218.2 BC009912 mRNA Translation: AAH09912.1 BC011130 mRNA Translation: AAH11130.1 BC015641 mRNA Translation: AAH15641.1 BC021166 mRNA Translation: AAH21166.2 BC022545 mRNA Translation: AAH22545.1 BC027725 mRNA Translation: AAH27725.1 BC050642 mRNA Translation: AAH50642.1 U88968 mRNA Translation: AAC39935.1 AF035286 mRNA Translation: AAB88178.1 |
CCDSi | CCDS97.1 [P06733-1] |
PIRi | A39579 S11696, A29170 |
RefSeqi | NP_001188412.1, NM_001201483.1 [P06733-2] NP_001419.1, NM_001428.3 [P06733-1] |
Genome annotation databases
Ensembli | ENST00000234590; ENSP00000234590; ENSG00000074800 [P06733-1] |
GeneIDi | 2023 |
KEGGi | hsa:2023 |
UCSCi | uc001apj.3, human [P06733-1] |
Keywords - Coding sequence diversityi
Alternative initiation, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14328 mRNA Translation: AAA52387.1 X16288, X16289, X16290 Genomic DNA Translation: CAA34360.1 M55914 mRNA Translation: AAA35698.1 Frameshift. X84907 mRNA Translation: CAA59331.1 BT007163 mRNA Translation: AAP35827.1 AK315417 mRNA Translation: BAG37806.1 AL833741 mRNA Translation: CAH56247.1 BX537400 mRNA Translation: CAD97642.1 AK222517 mRNA Translation: BAD96237.1 AK223192 mRNA Translation: BAD96912.1 DQ056744 Genomic DNA Translation: AAY43128.1 AL139415 Genomic DNA Translation: CAC42425.1 CH471130 Genomic DNA Translation: EAW71604.1 BC001810 mRNA Translation: AAH01810.1 BC004325 mRNA Translation: AAH04325.1 BC004458 mRNA Translation: AAH04458.1 BC009218 mRNA Translation: AAH09218.2 BC009912 mRNA Translation: AAH09912.1 BC011130 mRNA Translation: AAH11130.1 BC015641 mRNA Translation: AAH15641.1 BC021166 mRNA Translation: AAH21166.2 BC022545 mRNA Translation: AAH22545.1 BC027725 mRNA Translation: AAH27725.1 BC050642 mRNA Translation: AAH50642.1 U88968 mRNA Translation: AAC39935.1 AF035286 mRNA Translation: AAB88178.1 |
CCDSi | CCDS97.1 [P06733-1] |
PIRi | A39579 S11696, A29170 |
RefSeqi | NP_001188412.1, NM_001201483.1 [P06733-2] NP_001419.1, NM_001428.3 [P06733-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2PSN | X-ray | 2.20 | A/B/C/D | 1-434 | [»] | |
3B97 | X-ray | 2.20 | A/B/C/D | 2-434 | [»] | |
5JLZ | X-ray | 1.99 | E/F | 26-40 | [»] | |
5LAX | X-ray | 2.60 | E/F | 26-40 | [»] | |
5NI9 | X-ray | 1.33 | C | 326-340 | [»] | |
5NIG | X-ray | 1.35 | C | 326-340 | [»] | |
5OCK | X-ray | 1.60 | A | 5-21 | [»] | |
SMRi | P06733 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108338, 393 interactors |
IntActi | P06733, 121 interactors |
MINTi | P06733 |
STRINGi | 9606.ENSP00000234590 |
Chemistry databases
BindingDBi | P06733 |
ChEMBLi | CHEMBL3298 |
DrugBanki | DB11638, Artenimol DB09130, Copper DB01593, Zinc DB14487, Zinc acetate DB14533, Zinc chloride DB14548, Zinc sulfate, unspecified form |
Protein family/group databases
MoonDBi | P06733, Predicted |
MoonProti | P06733 |
PTM databases
GlyGeni | P06733, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P06733 |
MetOSitei | P06733 |
PhosphoSitePlusi | P06733 |
SwissPalmi | P06733 |
Polymorphism and mutation databases
BioMutai | ENO1 |
DMDMi | 119339 |
2D gel databases
DOSAC-COBS-2DPAGEi | P06733 |
OGPi | P06733 |
REPRODUCTION-2DPAGEi | IPI00465248 P06733 |
SWISS-2DPAGEi | P06733 |
UCD-2DPAGEi | P06733 |
Proteomic databases
CPTACi | CPTAC-70 |
EPDi | P06733 |
jPOSTi | P06733 |
MassIVEi | P06733 |
MaxQBi | P06733 |
PaxDbi | P06733 |
PeptideAtlasi | P06733 |
PRIDEi | P06733 |
ProteomicsDBi | 51919 [P06733-1] 51920 [P06733-2] |
TopDownProteomicsi | P06733-1 [P06733-1] P06733-2 [P06733-2] |
Protocols and materials databases
ABCDi | P06733, 5 sequenced antibodies |
Antibodypediai | 4351, 811 antibodies |
DNASUi | 2023 |
Genome annotation databases
Ensembli | ENST00000234590; ENSP00000234590; ENSG00000074800 [P06733-1] |
GeneIDi | 2023 |
KEGGi | hsa:2023 |
UCSCi | uc001apj.3, human [P06733-1] |
Organism-specific databases
CTDi | 2023 |
DisGeNETi | 2023 |
EuPathDBi | HostDB:ENSG00000074800.13 |
GeneCardsi | ENO1 |
HGNCi | HGNC:3350, ENO1 |
HPAi | ENSG00000074800, Low tissue specificity |
MIMi | 172430, gene |
neXtProti | NX_P06733 |
OpenTargetsi | ENSG00000074800 |
PharmGKBi | PA27786 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2670, Eukaryota |
GeneTreei | ENSGT00950000182805 |
HOGENOMi | CLU_031223_0_0_1 |
InParanoidi | P06733 |
OMAi | GPELVGY |
PhylomeDBi | P06733 |
TreeFami | TF300391 |
Enzyme and pathway databases
UniPathwayi | UPA00109;UER00187 |
BioCyci | MetaCyc:ENSG00000074800-MONOMER |
BRENDAi | 4.2.1.11, 2681 |
PathwayCommonsi | P06733 |
Reactomei | R-HSA-70171, Glycolysis R-HSA-70263, Gluconeogenesis R-HSA-9636667, Manipulation of host energy metabolism |
SABIO-RKi | P06733 |
SIGNORi | P06733 |
Miscellaneous databases
BioGRID-ORCSi | 2023, 376 hits in 860 CRISPR screens |
ChiTaRSi | ENO1, human |
EvolutionaryTracei | P06733 |
GeneWikii | Alpha-enolase |
GenomeRNAii | 2023 |
Pharosi | P06733, Tchem |
PROi | PR:P06733 |
RNActi | P06733, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000074800, Expressed in cortex of kidney and 243 other tissues |
ExpressionAtlasi | P06733, baseline and differential |
Genevisiblei | P06733, HS |
Family and domain databases
CDDi | cd03313, enolase, 1 hit |
Gene3Di | 3.20.20.120, 1 hit 3.30.390.10, 1 hit |
HAMAPi | MF_00318, Enolase, 1 hit |
InterProi | View protein in InterPro IPR000941, Enolase IPR036849, Enolase-like_C_sf IPR029017, Enolase-like_N IPR020810, Enolase_C IPR020809, Enolase_CS IPR020811, Enolase_N |
PANTHERi | PTHR11902, PTHR11902, 1 hit |
Pfami | View protein in Pfam PF00113, Enolase_C, 1 hit PF03952, Enolase_N, 1 hit |
PIRSFi | PIRSF001400, Enolase, 1 hit |
PRINTSi | PR00148, ENOLASE |
SFLDi | SFLDG00178, enolase, 1 hit |
SMARTi | View protein in SMART SM01192, Enolase_C, 1 hit SM01193, Enolase_N, 1 hit |
SUPFAMi | SSF51604, SSF51604, 1 hit SSF54826, SSF54826, 1 hit |
TIGRFAMsi | TIGR01060, eno, 1 hit |
PROSITEi | View protein in PROSITE PS00164, ENOLASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ENOA_HUMAN | |
Accessioni | P06733Primary (citable) accession number: P06733 Secondary accession number(s): B2RD59 Q9UM55 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 246 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations