CEACAM5

Functionⁱ

Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).3 Publications

(Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.1 Publication

GO - Molecular functionⁱ

GPI anchor binding
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 10931872
identical protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 26483485
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18086185

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 2803308
homophilic cell adhesion via plasma membrane adhesion molecules
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 2803308
homotypic cell-cell adhesion
Source: UniProtKB
Inferred from direct assayⁱ
- 10864933
leukocyte migration Source: Reactome
negative regulation of anoikis
Source: UniProtKB
Inferred from direct assayⁱ
- 10910050
negative regulation of apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 11448920
negative regulation of myotube differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 10931872
- 8408226

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis, Cell adhesion

Biological process

Apoptosis, Cell adhesion

Enzyme and pathway databases

Reactomeⁱ	R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins R-HSA-202733 Cell surface interactions at the vascular wall

Reactomeⁱ

R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-202733 Cell surface interactions at the vascular wall

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Carcinoembryonic antigen-related cell adhesion molecule 5 Alternative name(s): Carcinoembryonic antigen Short name: CEA Meconium antigen 100 CD_antigen: CD66e
Gene namesⁱ	Name:CEACAM5 Synonyms:CEA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000105388.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1817 CEACAM5
MIMⁱ	114890 gene
neXtProtⁱ	NX_P06731

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	63	F → I: No effect on dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication	1
Mutagenesisⁱ	63	F → R: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication	1
Mutagenesisⁱ	66	S → N: Abolishes dimerization. 2 Publications	1
Mutagenesisⁱ	68	Y → A: Abolishes dimerization. 1 Publication	1
Mutagenesisⁱ	68	Y → F: No effect on dimerization. 1 Publication	1
Mutagenesisⁱ	69	K → A: Abolishes dimerization. 1 Publication	1
Mutagenesisⁱ	73	V → A: Abolishes dimerization. 1 Publication	1
Mutagenesisⁱ	74	D → A: No effect on dimerization. 1 Publication	1
Mutagenesisⁱ	74	D → L or R: Abolishes dimerization. 1 Publication	1
Mutagenesisⁱ	78	Q → L or R: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 2 Publications	1
Mutagenesisⁱ	125	I → A: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication	1
Mutagenesisⁱ	129	L → A or C: No effect on dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication	1
Mutagenesisⁱ	129	L → S: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication	1
Mutagenesisⁱ	133	E → A: Abolishes dimerization. 1 Publication	1

Keywords - Diseaseⁱ

Oncogene

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1048
PharmGKBⁱ	PA26361

Chemistry databases

ChEMBLⁱ	CHEMBL3712881

ChEMBLⁱ

CHEMBL3712881

Polymorphism and mutation databases

BioMutaⁱ	CEACAM5
DMDMⁱ	317373456

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 34	Add BLAST	34
ChainⁱPRO_0000014566	35 – 685	Carcinoembryonic antigen-related cell adhesion molecule 5Add BLAST	651
PropeptideⁱPRO_0000014567	686 – 702	Removed in mature formSequence analysisAdd BLAST	17

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	104	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	115	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	152	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Disulfide bondⁱ	167 ↔ 215	PROSITE-ProRule annotation
Glycosylationⁱ	182	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	197	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	204	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	208	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	246	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication	1
Glycosylationⁱ	256	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Disulfide bondⁱ	259 ↔ 299	PROSITE-ProRule annotation
Glycosylationⁱ	274	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	288	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	292	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	309	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	330	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Disulfide bondⁱ	345 ↔ 393	PROSITE-ProRule annotation
Glycosylationⁱ	351	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	360	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	375	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	432	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Disulfide bondⁱ	437 ↔ 477	PROSITE-ProRule annotation
Glycosylationⁱ	466	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	480	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	508	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Disulfide bondⁱ	523 ↔ 571	PROSITE-ProRule annotation
Glycosylationⁱ	529	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	553	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	560	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication	1
Glycosylationⁱ	580	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	612	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Disulfide bondⁱ	615 ↔ 655	PROSITE-ProRule annotation
Glycosylationⁱ	650	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Glycosylationⁱ	665	N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation	1
Lipidationⁱ	685	GPI-anchor amidated alanine1 Publication	1

Post-translational modificationⁱ

Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDⁱ	P06731
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P06731
PaxDbⁱ	P06731
PeptideAtlas More...PeptideAtlasⁱ	P06731
PRIDEⁱ	P06731
ProteomicsDBⁱ	51917

PTM databases

GlyConnectⁱ	1070 1071
iPTMnetⁱ	P06731
PhosphoSitePlusⁱ	P06731

Expressionⁱ

Tissue specificityⁱ

Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000105388 Expressed in 131 organ(s), highest expression level in colonic mucosa
CleanExⁱ	HS_CEACAM5
ExpressionAtlasⁱ	P06731 baseline and differential
Genevisibleⁱ	P06731 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB000021 CAB000022 HPA011041 HPA019758

HPAⁱ

CAB000021
CAB000022
HPA011041
HPA019758

Interactionⁱ

Subunit structureⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		6	EBI-3914938,EBI-3914938

With

Entry

#Exp.

IntAct

Notes

itself

6

EBI-3914938,EBI-3914938

GO - Molecular functionⁱ

identical protein binding
Source: UniProtKB
Inferred from direct assayⁱ
- 26483485
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 18086185

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107478, 6 interactors
Database of interacting proteins More...DIPⁱ	DIP-57769N
IntActⁱ	P06731, 6 interactors
Molecular INTeraction database More...MINTⁱ	P06731
STRINGⁱ	9606.ENSP00000221992

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	37 – 46	Combined sources	10
Beta strandⁱ	51 – 57	Combined sources	7
Beta strandⁱ	60 – 72	Combined sources	13
Helixⁱ	75 – 77	Combined sources	3
Beta strandⁱ	78 – 83	Combined sources	6
Turnⁱ	84 – 87	Combined sources	4
Beta strandⁱ	88 – 91	Combined sources	4
Beta strandⁱ	99 – 101	Combined sources	3
Beta strandⁱ	107 – 109	Combined sources	3
Helixⁱ	114 – 116	Combined sources	3
Beta strandⁱ	118 – 126	Combined sources	9
Beta strandⁱ	132 – 141	Combined sources	10

Show more details

3D structure databases

ProteinModelPortalⁱ	P06731
SMRⁱ	P06731
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P06731

EvolutionaryTraceⁱ

P06731

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	35 – 144	Ig-like V-typeBy similarityAdd BLAST	110
Domainⁱ	145 – 232	Ig-like C2-type 1PROSITE-ProRule annotationAdd BLAST	88
Domainⁱ	240 – 315	Ig-like C2-type 2PROSITE-ProRule annotationAdd BLAST	76
Domainⁱ	323 – 410	Ig-like C2-type 3PROSITE-ProRule annotationAdd BLAST	88
Domainⁱ	418 – 495	Ig-like C2-type 4PROSITE-ProRule annotationAdd BLAST	78
Domainⁱ	501 – 588	Ig-like C2-type 5PROSITE-ProRule annotationAdd BLAST	88
Domainⁱ	593 – 675	Ig-like C2-type 6PROSITE-ProRule annotationAdd BLAST	83

Sequence similaritiesⁱ

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IFE1 Eukaryota ENOG410YR1P LUCA
HOGENOMⁱ	HOG000233417
HOVERGENⁱ	HBG007922
InParanoidⁱ	P06731
KEGG Orthology (KO) More...KOⁱ	K06499
PhylomeDBⁱ	P06731
TreeFamⁱ	TF336859

Family and domain databases

Gene3Dⁱ	2.60.40.10, 7 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013106 Ig_V-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13895 Ig_2, 2 hits PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 7 hits SM00408 IGc2, 6 hits
SUPFAMⁱ	SSF48726 SSF48726, 7 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 6 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P06731-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESPSAPPHR WCIPWQRLLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE 
        60         70         80         90        100
VLLLVHNLPQ HLFGYSWYKG ERVDGNRQII GYVIGTQQAT PGPAYSGREI 
       110        120        130        140        150
IYPNASLLIQ NIIQNDTGFY TLHVIKSDLV NEEATGQFRV YPELPKPSIS 
       160        170        180        190        200
SNNSKPVEDK DAVAFTCEPE TQDATYLWWV NNQSLPVSPR LQLSNGNRTL 
       210        220        230        240        250
TLFNVTRNDT ASYKCETQNP VSARRSDSVI LNVLYGPDAP TISPLNTSYR 
       260        270        280        290        300
SGENLNLSCH AASNPPAQYS WFVNGTFQQS TQELFIPNIT VNNSGSYTCQ 
       310        320        330        340        350
AHNSDTGLNR TTVTTITVYA EPPKPFITSN NSNPVEDEDA VALTCEPEIQ 
       360        370        380        390        400
NTTYLWWVNN QSLPVSPRLQ LSNDNRTLTL LSVTRNDVGP YECGIQNKLS 
       410        420        430        440        450
VDHSDPVILN VLYGPDDPTI SPSYTYYRPG VNLSLSCHAA SNPPAQYSWL 
       460        470        480        490        500
IDGNIQQHTQ ELFISNITEK NSGLYTCQAN NSASGHSRTT VKTITVSAEL 
       510        520        530        540        550
PKPSISSNNS KPVEDKDAVA FTCEPEAQNT TYLWWVNGQS LPVSPRLQLS 
       560        570        580        590        600
NGNRTLTLFN VTRNDARAYV CGIQNSVSAN RSDPVTLDVL YGPDTPIISP 
       610        620        630        640        650
PDSSYLSGAN LNLSCHSASN PSPQYSWRIN GIPQQHTQVL FIAKITPNNN 
       660        670        680        690        700
GTYACFVSNL ATGRNNSIVK SITVSASGTS PGLSAGATVG IMIGVLVGVA 

LI

Length:702

Mass (Da):76,795

Last modified:January 11, 2011 - v3

Checksum:ⁱ86318E244155DB58

GO

Isoform 2 (identifier: P06731-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
320-320: Missing.

« Hide

        10         20         30         40         50
MESPSAPPHR WCIPWQRLLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE 
        60         70         80         90        100
VLLLVHNLPQ HLFGYSWYKG ERVDGNRQII GYVIGTQQAT PGPAYSGREI 
       110        120        130        140        150
IYPNASLLIQ NIIQNDTGFY TLHVIKSDLV NEEATGQFRV YPELPKPSIS 
       160        170        180        190        200
SNNSKPVEDK DAVAFTCEPE TQDATYLWWV NNQSLPVSPR LQLSNGNRTL 
       210        220        230        240        250
TLFNVTRNDT ASYKCETQNP VSARRSDSVI LNVLYGPDAP TISPLNTSYR 
       260        270        280        290        300
SGENLNLSCH AASNPPAQYS WFVNGTFQQS TQELFIPNIT VNNSGSYTCQ 
       310        320        330        340        350
AHNSDTGLNR TTVTTITVYE PPKPFITSNN SNPVEDEDAV ALTCEPEIQN 
       360        370        380        390        400
TTYLWWVNNQ SLPVSPRLQL SNDNRTLTLL SVTRNDVGPY ECGIQNKLSV 
       410        420        430        440        450
DHSDPVILNV LYGPDDPTIS PSYTYYRPGV NLSLSCHAAS NPPAQYSWLI 
       460        470        480        490        500
DGNIQQHTQE LFISNITEKN SGLYTCQANN SASGHSRTTV KTITVSAELP 
       510        520        530        540        550
KPSISSNNSK PVEDKDAVAF TCEPEAQNTT YLWWVNGQSL PVSPRLQLSN 
       560        570        580        590        600
GNRTLTLFNV TRNDARAYVC GIQNSVSANR SDPVTLDVLY GPDTPIISPP 
       610        620        630        640        650
DSSYLSGANL NLSCHSASNP SPQYSWRING IPQQHTQVLF IAKITPNNNG 
       660        670        680        690        700
TYACFVSNLA TGRNNSIVKS ITVSASGTSP GLSAGATVGI MIGVLVGVAL 

I

Show »

Length:701

Mass (Da):76,724

Checksum:ⁱ19149D8E5BDE18E5

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A024R0K5	A0A024R0K5_HUMAN	Carcinoembryonic antigen-related ce... Carcinoembryonic antigen-related cell adhesion molecule 5, isoform CRA_a	CEACAM5 hCG_1642477	702	Annotation score:
A0A087WYX0	A0A087WYX0_HUMAN	Carcinoembryonic antigen-related ce... Carcinoembryonic antigen-related cell adhesion molecule 5	CEACAM5	524	Annotation score:
T2HUW8	T2HUW8_HUMAN	Carcinoembryonic antigen-related ce... Carcinoembryonic antigen-related cell adhesion molecule 5 isoform 3D	CEACAM5	346	Annotation score:
M0R3J1	M0R3J1_HUMAN	Carcinoembryonic antigen-related ce... Carcinoembryonic antigen-related cell adhesion molecule 5	CEACAM5	194	Annotation score:
M0QX98	M0QX98_HUMAN	Carcinoembryonic antigen-related ce... Carcinoembryonic antigen-related cell adhesion molecule 5	CEACAM5	141	Annotation score:

Sequence cautionⁱ

The sequence AAA62835 differs from that shown. Reason: Frameshift at positions 359 and 361.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	641	F → L in AAA62835 (PubMed:2342461).Curated	1
Sequence conflictⁱ	646	T → Q in AAA62835 (PubMed:2342461).Curated	1
Sequence conflictⁱ	689	V → A in AAA62835 (PubMed:2342461).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_061310	80	I → V. Corresponds to variant dbSNP:rs12971352Ensembl.	1
Natural variantⁱVAR_061311	83	V → A. Corresponds to variant dbSNP:rs28683503Ensembl.	1
Natural variantⁱVAR_056028	137	Q → P. Corresponds to variant dbSNP:rs3815780Ensembl.	1
Natural variantⁱVAR_031091	340	A → D. Corresponds to variant dbSNP:rs10407503Ensembl.	1
Natural variantⁱVAR_024493	398	K → E5 PublicationsCorresponds to variant dbSNP:rs7249230Ensembl.	1
Natural variantⁱVAR_031092	664	R → S. Corresponds to variant dbSNP:rs10423171Ensembl.	1
Natural variantⁱVAR_056029	678	G → R. Corresponds to variant dbSNP:rs9621Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_053414	320	Missing in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M17303 Genomic DNA Translation: AAB59513.1 M29540 mRNA Translation: AAA51967.1 M59262 M59261 Genomic DNA Translation: AAA62835.1 Frameshift. M59709 Genomic DNA No translation available. M59710 Genomic DNA No translation available. AC008999 Genomic DNA No translation available. X16455 mRNA Translation: CAA34474.1 M15042 mRNA Translation: AAA51963.1 M16234 mRNA Translation: AAA51972.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS12584.1 [P06731-1] CCDS77302.1 [P06731-2]
PIRⁱ	A36319
NCBI Reference Sequences More...RefSeqⁱ	NP_001278413.1, NM_001291484.2 NP_001295327.1, NM_001308398.1 NP_004354.3, NM_004363.5
UniGeneⁱ	Hs.709196

Genome annotation databases

Ensemblⁱ	ENST00000221992; ENSP00000221992; ENSG00000105388 ENST00000398599; ENSP00000381600; ENSG00000105388 ENST00000405816; ENSP00000385072; ENSG00000105388
GeneIDⁱ	1048
KEGGⁱ	hsa:1048
UCSC genome browser More...UCSCⁱ	uc002orj.2 human [P06731-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P06731	Uncharacterized protein (Fragment)		HUMAN		152	UniRef100_P06731
Carcinoembryonic antigen (Fragment)		HUMAN		37

Protein	Similar proteins		Species	Score	Length	Source
P06731	Uncharacterized protein (Fragment)		HUMAN		152	UniRef90_P06731
CEACAM5 isoform 2		PANTR		702
Uncharacterized protein		PONAB		702
Uncharacterized protein		PANPA		702
Uncharacterized protein		NOMLE		691
+11

Protein	Similar proteins		Species	Score	Length	Source
P06731	Uncharacterized protein (Fragment)		HUMAN		152	UniRef50_P06731
Uncharacterized protein		PANPA		702
CEACAM5 isoform 2		PANTR		702
Uncharacterized protein		PONAB		702
Uncharacterized protein		NOMLE		691
+34

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M17303 Genomic DNA Translation: AAB59513.1 M29540 mRNA Translation: AAA51967.1 M59262 M59261 Genomic DNA Translation: AAA62835.1 Frameshift. M59709 Genomic DNA No translation available. M59710 Genomic DNA No translation available. AC008999 Genomic DNA No translation available. X16455 mRNA Translation: CAA34474.1 M15042 mRNA Translation: AAA51963.1 M16234 mRNA Translation: AAA51972.1
CCDSⁱ	CCDS12584.1 [P06731-1] CCDS77302.1 [P06731-2]
PIRⁱ	A36319
RefSeqⁱ	NP_001278413.1, NM_001291484.2 NP_001295327.1, NM_001308398.1 NP_004354.3, NM_004363.5
UniGeneⁱ	Hs.709196

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1E07	X-ray	-	A	35-676	[»]
	2QSQ	X-ray	1.95	A/B	34-144	[»]
	2QST	X-ray	2.90	A/B	34-144	[»]
	2VER	NMR	-	N	35-144	[»]
ProteinModelPortalⁱ	P06731
SMRⁱ	P06731
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107478, 6 interactors
DIPⁱ	DIP-57769N
IntActⁱ	P06731, 6 interactors
MINTⁱ	P06731
STRINGⁱ	9606.ENSP00000221992

Chemistry databases

ChEMBLⁱ	CHEMBL3712881

ChEMBLⁱ

CHEMBL3712881

PTM databases

GlyConnectⁱ	1070 1071
iPTMnetⁱ	P06731
PhosphoSitePlusⁱ	P06731

Polymorphism and mutation databases

BioMutaⁱ	CEACAM5
DMDMⁱ	317373456

Proteomic databases

EPDⁱ	P06731
MaxQBⁱ	P06731
PaxDbⁱ	P06731
PeptideAtlasⁱ	P06731
PRIDEⁱ	P06731
ProteomicsDBⁱ	51917

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1048
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000221992; ENSP00000221992; ENSG00000105388 ENST00000398599; ENSP00000381600; ENSG00000105388 ENST00000405816; ENSP00000385072; ENSG00000105388
GeneIDⁱ	1048
KEGGⁱ	hsa:1048
UCSCⁱ	uc002orj.2 human [P06731-1]

Organism-specific databases

CTDⁱ	1048
DisGeNETⁱ	1048
EuPathDBⁱ	HostDB:ENSG00000105388.15
GeneCardsⁱ	CEACAM5
H-InvDBⁱ	HIX0027513
HGNCⁱ	HGNC:1817 CEACAM5
HPAⁱ	CAB000021 CAB000022 HPA011041 HPA019758
MIMⁱ	114890 gene
neXtProtⁱ	NX_P06731
PharmGKBⁱ	PA26361
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFE1 Eukaryota ENOG410YR1P LUCA
HOGENOMⁱ	HOG000233417
HOVERGENⁱ	HBG007922
InParanoidⁱ	P06731
KOⁱ	K06499
PhylomeDBⁱ	P06731
TreeFamⁱ	TF336859

Enzyme and pathway databases

Reactomeⁱ	R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins R-HSA-202733 Cell surface interactions at the vascular wall

Reactomeⁱ

R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

ChiTaRSⁱ	CEACAM5 human
EvolutionaryTraceⁱ	P06731
GeneWikiⁱ	CEACAM5
GenomeRNAiⁱ	1048
Protein Ontology More...PROⁱ	PR:P06731
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000105388 Expressed in 131 organ(s), highest expression level in colonic mucosa
CleanExⁱ	HS_CEACAM5
ExpressionAtlasⁱ	P06731 baseline and differential
Genevisibleⁱ	P06731 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 7 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013106 Ig_V-set
Pfamⁱ	View protein in Pfam PF13895 Ig_2, 2 hits PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 7 hits SM00408 IGc2, 6 hits
SUPFAMⁱ	SSF48726 SSF48726, 7 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 6 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CEAM5_HUMAN
Accessionⁱ	P06731Primary (citable) accession number: P06731 Secondary accession number(s): H9KVA7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
	Last sequence update:	January 11, 2011
	Last modified:	October 10, 2018
	This is version 184 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

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UniProtKB - P06731 (CEAM5_HUMAN)

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Carcinoembryonic antigen-related cell adhesion molecule 5

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

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Plasma Membrane

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ