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Protein

Carcinoembryonic antigen-related cell adhesion molecule 5

Gene

CEACAM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).3 Publications
(Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.1 Publication

GO - Molecular functioni

  • GPI anchor binding Source: UniProtKB
  • identical protein binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processApoptosis, Cell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 5
Alternative name(s):
Carcinoembryonic antigen
Short name:
CEA
Meconium antigen 100
CD_antigen: CD66e
Gene namesi
Name:CEACAM5
Synonyms:CEA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105388.15
HGNCiHGNC:1817 CEACAM5
MIMi114890 gene
neXtProtiNX_P06731

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi63F → I: No effect on dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication1
Mutagenesisi63F → R: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication1
Mutagenesisi66S → N: Abolishes dimerization. 2 Publications1
Mutagenesisi68Y → A: Abolishes dimerization. 1 Publication1
Mutagenesisi68Y → F: No effect on dimerization. 1 Publication1
Mutagenesisi69K → A: Abolishes dimerization. 1 Publication1
Mutagenesisi73V → A: Abolishes dimerization. 1 Publication1
Mutagenesisi74D → A: No effect on dimerization. 1 Publication1
Mutagenesisi74D → L or R: Abolishes dimerization. 1 Publication1
Mutagenesisi78Q → L or R: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 2 Publications1
Mutagenesisi125I → A: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication1
Mutagenesisi129L → A or C: No effect on dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication1
Mutagenesisi129L → S: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication1
Mutagenesisi133E → A: Abolishes dimerization. 1 Publication1

Keywords - Diseasei

Oncogene

Organism-specific databases

DisGeNETi1048
PharmGKBiPA26361

Chemistry databases

ChEMBLiCHEMBL3712881

Polymorphism and mutation databases

BioMutaiCEACAM5
DMDMi317373456

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Add BLAST34
ChainiPRO_000001456635 – 685Carcinoembryonic antigen-related cell adhesion molecule 5Add BLAST651
PropeptideiPRO_0000014567686 – 702Removed in mature formSequence analysisAdd BLAST17

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi104N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi115N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi152N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi167 ↔ 215PROSITE-ProRule annotation
Glycosylationi182N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi197N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi204N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi208N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi246N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication1
Glycosylationi256N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi259 ↔ 299PROSITE-ProRule annotation
Glycosylationi274N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi288N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi292N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi309N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi330N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi345 ↔ 393PROSITE-ProRule annotation
Glycosylationi351N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi360N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi375N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi432N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi437 ↔ 477PROSITE-ProRule annotation
Glycosylationi466N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi480N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi508N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi523 ↔ 571PROSITE-ProRule annotation
Glycosylationi529N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi553N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi560N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication1
Glycosylationi580N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi612N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi615 ↔ 655PROSITE-ProRule annotation
Glycosylationi650N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi665N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Lipidationi685GPI-anchor amidated alanine1 Publication1

Post-translational modificationi

Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiP06731
MaxQBiP06731
PaxDbiP06731
PeptideAtlasiP06731
PRIDEiP06731
ProteomicsDBi51917

PTM databases

GlyConnecti1070
1071
iPTMnetiP06731
PhosphoSitePlusiP06731

Expressioni

Tissue specificityi

Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.1 Publication

Gene expression databases

BgeeiENSG00000105388 Expressed in 131 organ(s), highest expression level in colonic mucosa
CleanExiHS_CEACAM5
ExpressionAtlasiP06731 baseline and differential
GenevisibleiP06731 HS

Organism-specific databases

HPAiCAB000021
CAB000022
HPA011041
HPA019758

Interactioni

Subunit structurei

Homodimer.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself6EBI-3914938,EBI-3914938

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107478, 6 interactors
DIPiDIP-57769N
IntActiP06731, 6 interactors
MINTiP06731
STRINGi9606.ENSP00000221992

Structurei

Secondary structure

1702
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP06731
SMRiP06731
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06731

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 144Ig-like V-typeBy similarityAdd BLAST110
Domaini145 – 232Ig-like C2-type 1PROSITE-ProRule annotationAdd BLAST88
Domaini240 – 315Ig-like C2-type 2PROSITE-ProRule annotationAdd BLAST76
Domaini323 – 410Ig-like C2-type 3PROSITE-ProRule annotationAdd BLAST88
Domaini418 – 495Ig-like C2-type 4PROSITE-ProRule annotationAdd BLAST78
Domaini501 – 588Ig-like C2-type 5PROSITE-ProRule annotationAdd BLAST88
Domaini593 – 675Ig-like C2-type 6PROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFE1 Eukaryota
ENOG410YR1P LUCA
HOGENOMiHOG000233417
HOVERGENiHBG007922
InParanoidiP06731
KOiK06499
PhylomeDBiP06731
TreeFamiTF336859

Family and domain databases

Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 7 hits
SM00408 IGc2, 6 hits
SUPFAMiSSF48726 SSF48726, 7 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 6 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P06731-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESPSAPPHR WCIPWQRLLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE
60 70 80 90 100
VLLLVHNLPQ HLFGYSWYKG ERVDGNRQII GYVIGTQQAT PGPAYSGREI
110 120 130 140 150
IYPNASLLIQ NIIQNDTGFY TLHVIKSDLV NEEATGQFRV YPELPKPSIS
160 170 180 190 200
SNNSKPVEDK DAVAFTCEPE TQDATYLWWV NNQSLPVSPR LQLSNGNRTL
210 220 230 240 250
TLFNVTRNDT ASYKCETQNP VSARRSDSVI LNVLYGPDAP TISPLNTSYR
260 270 280 290 300
SGENLNLSCH AASNPPAQYS WFVNGTFQQS TQELFIPNIT VNNSGSYTCQ
310 320 330 340 350
AHNSDTGLNR TTVTTITVYA EPPKPFITSN NSNPVEDEDA VALTCEPEIQ
360 370 380 390 400
NTTYLWWVNN QSLPVSPRLQ LSNDNRTLTL LSVTRNDVGP YECGIQNKLS
410 420 430 440 450
VDHSDPVILN VLYGPDDPTI SPSYTYYRPG VNLSLSCHAA SNPPAQYSWL
460 470 480 490 500
IDGNIQQHTQ ELFISNITEK NSGLYTCQAN NSASGHSRTT VKTITVSAEL
510 520 530 540 550
PKPSISSNNS KPVEDKDAVA FTCEPEAQNT TYLWWVNGQS LPVSPRLQLS
560 570 580 590 600
NGNRTLTLFN VTRNDARAYV CGIQNSVSAN RSDPVTLDVL YGPDTPIISP
610 620 630 640 650
PDSSYLSGAN LNLSCHSASN PSPQYSWRIN GIPQQHTQVL FIAKITPNNN
660 670 680 690 700
GTYACFVSNL ATGRNNSIVK SITVSASGTS PGLSAGATVG IMIGVLVGVA

LI
Length:702
Mass (Da):76,795
Last modified:January 11, 2011 - v3
Checksum:i86318E244155DB58
GO
Isoform 2 (identifier: P06731-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     320-320: Missing.

Show »
Length:701
Mass (Da):76,724
Checksum:i19149D8E5BDE18E5
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A024R0K5A0A024R0K5_HUMAN
Carcinoembryonic antigen-related ce...
CEACAM5 hCG_1642477
702Annotation score:
A0A087WYX0A0A087WYX0_HUMAN
Carcinoembryonic antigen-related ce...
CEACAM5
524Annotation score:
T2HUW8T2HUW8_HUMAN
Carcinoembryonic antigen-related ce...
CEACAM5
346Annotation score:
M0R3J1M0R3J1_HUMAN
Carcinoembryonic antigen-related ce...
CEACAM5
194Annotation score:
M0QX98M0QX98_HUMAN
Carcinoembryonic antigen-related ce...
CEACAM5
141Annotation score:

Sequence cautioni

The sequence AAA62835 differs from that shown. Reason: Frameshift at positions 359 and 361.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti641F → L in AAA62835 (PubMed:2342461).Curated1
Sequence conflicti646T → Q in AAA62835 (PubMed:2342461).Curated1
Sequence conflicti689V → A in AAA62835 (PubMed:2342461).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06131080I → V. Corresponds to variant dbSNP:rs12971352Ensembl.1
Natural variantiVAR_06131183V → A. Corresponds to variant dbSNP:rs28683503Ensembl.1
Natural variantiVAR_056028137Q → P. Corresponds to variant dbSNP:rs3815780Ensembl.1
Natural variantiVAR_031091340A → D. Corresponds to variant dbSNP:rs10407503Ensembl.1
Natural variantiVAR_024493398K → E5 PublicationsCorresponds to variant dbSNP:rs7249230Ensembl.1
Natural variantiVAR_031092664R → S. Corresponds to variant dbSNP:rs10423171Ensembl.1
Natural variantiVAR_056029678G → R. Corresponds to variant dbSNP:rs9621Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053414320Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17303 Genomic DNA Translation: AAB59513.1
M29540 mRNA Translation: AAA51967.1
M59262
, M59255, M59256, M59257, M59258, M59259, M59260, M59261 Genomic DNA Translation: AAA62835.1 Frameshift.
M59709 Genomic DNA No translation available.
M59710 Genomic DNA No translation available.
AC008999 Genomic DNA No translation available.
X16455 mRNA Translation: CAA34474.1
M15042 mRNA Translation: AAA51963.1
M16234 mRNA Translation: AAA51972.1
CCDSiCCDS12584.1 [P06731-1]
CCDS77302.1 [P06731-2]
PIRiA36319
RefSeqiNP_001278413.1, NM_001291484.2
NP_001295327.1, NM_001308398.1
NP_004354.3, NM_004363.5
UniGeneiHs.709196

Genome annotation databases

EnsembliENST00000221992; ENSP00000221992; ENSG00000105388
ENST00000398599; ENSP00000381600; ENSG00000105388
ENST00000405816; ENSP00000385072; ENSG00000105388
GeneIDi1048
KEGGihsa:1048
UCSCiuc002orj.2 human [P06731-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17303 Genomic DNA Translation: AAB59513.1
M29540 mRNA Translation: AAA51967.1
M59262
, M59255, M59256, M59257, M59258, M59259, M59260, M59261 Genomic DNA Translation: AAA62835.1 Frameshift.
M59709 Genomic DNA No translation available.
M59710 Genomic DNA No translation available.
AC008999 Genomic DNA No translation available.
X16455 mRNA Translation: CAA34474.1
M15042 mRNA Translation: AAA51963.1
M16234 mRNA Translation: AAA51972.1
CCDSiCCDS12584.1 [P06731-1]
CCDS77302.1 [P06731-2]
PIRiA36319
RefSeqiNP_001278413.1, NM_001291484.2
NP_001295327.1, NM_001308398.1
NP_004354.3, NM_004363.5
UniGeneiHs.709196

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E07X-ray-A35-676[»]
2QSQX-ray1.95A/B34-144[»]
2QSTX-ray2.90A/B34-144[»]
2VERNMR-N35-144[»]
ProteinModelPortaliP06731
SMRiP06731
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107478, 6 interactors
DIPiDIP-57769N
IntActiP06731, 6 interactors
MINTiP06731
STRINGi9606.ENSP00000221992

Chemistry databases

ChEMBLiCHEMBL3712881

PTM databases

GlyConnecti1070
1071
iPTMnetiP06731
PhosphoSitePlusiP06731

Polymorphism and mutation databases

BioMutaiCEACAM5
DMDMi317373456

Proteomic databases

EPDiP06731
MaxQBiP06731
PaxDbiP06731
PeptideAtlasiP06731
PRIDEiP06731
ProteomicsDBi51917

Protocols and materials databases

DNASUi1048
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221992; ENSP00000221992; ENSG00000105388
ENST00000398599; ENSP00000381600; ENSG00000105388
ENST00000405816; ENSP00000385072; ENSG00000105388
GeneIDi1048
KEGGihsa:1048
UCSCiuc002orj.2 human [P06731-1]

Organism-specific databases

CTDi1048
DisGeNETi1048
EuPathDBiHostDB:ENSG00000105388.15
GeneCardsiCEACAM5
H-InvDBiHIX0027513
HGNCiHGNC:1817 CEACAM5
HPAiCAB000021
CAB000022
HPA011041
HPA019758
MIMi114890 gene
neXtProtiNX_P06731
PharmGKBiPA26361
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFE1 Eukaryota
ENOG410YR1P LUCA
HOGENOMiHOG000233417
HOVERGENiHBG007922
InParanoidiP06731
KOiK06499
PhylomeDBiP06731
TreeFamiTF336859

Enzyme and pathway databases

ReactomeiR-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-202733 Cell surface interactions at the vascular wall

Miscellaneous databases

ChiTaRSiCEACAM5 human
EvolutionaryTraceiP06731
GeneWikiiCEACAM5
GenomeRNAii1048
PROiPR:P06731
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105388 Expressed in 131 organ(s), highest expression level in colonic mucosa
CleanExiHS_CEACAM5
ExpressionAtlasiP06731 baseline and differential
GenevisibleiP06731 HS

Family and domain databases

Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF13895 Ig_2, 2 hits
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 7 hits
SM00408 IGc2, 6 hits
SUPFAMiSSF48726 SSF48726, 7 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCEAM5_HUMAN
AccessioniPrimary (citable) accession number: P06731
Secondary accession number(s): H9KVA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 11, 2011
Last modified: October 10, 2018
This is version 184 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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