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UniProtKB - P06731 (CEAM5_HUMAN)

Entry version 199 (02 Dec 2020)
Sequence version 3 (11 Jan 2011)
Previous versions | rss
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Protein

Carcinoembryonic antigen-related cell adhesion molecule 5

Gene

CEACAM5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).3 Publications
(Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis, Cell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P06731

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-163125, Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-202733, Cell surface interactions at the vascular wall

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 5
Alternative name(s):
Carcinoembryonic antigen
Short name:
CEA
Meconium antigen 100
CD_antigen: CD66e
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CEACAM5
Synonyms:CEA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000105388.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:1817, CEACAM5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		114890, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P06731

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi63F → I: No effect on dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication1
Mutagenesisi63F → R: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication1
Mutagenesisi66S → N: Abolishes dimerization. 2 Publications1
Mutagenesisi68Y → A: Abolishes dimerization. 1 Publication1
Mutagenesisi68Y → F: No effect on dimerization. 1 Publication1
Mutagenesisi69K → A: Abolishes dimerization. 1 Publication1
Mutagenesisi73V → A: Abolishes dimerization. 1 Publication1
Mutagenesisi74D → A: No effect on dimerization. 1 Publication1
Mutagenesisi74D → L or R: Abolishes dimerization. 1 Publication1
Mutagenesisi78Q → L or R: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 2 Publications1
Mutagenesisi125I → A: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication1
Mutagenesisi129L → A or C: No effect on dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication1
Mutagenesisi129L → S: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication1
Mutagenesisi133E → A: Abolishes dimerization. 1 Publication1

Keywords - Diseasei

Oncogene

Organism-specific databases

DisGeNET

More...DisGeNETi		1048

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26361

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P06731, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3712881

Drug and drug target database

More...DrugBanki		DB05097, Labetuzumab
DB08217, S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CEACAM5

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373456

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 34Add BLAST34
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001456635 – 685Carcinoembryonic antigen-related cell adhesion molecule 5Add BLAST651
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000014567686 – 702Removed in mature formSequence analysisAdd BLAST17

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi104N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi115N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi152N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi167 ↔ 215PROSITE-ProRule annotation
Glycosylationi182N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi197N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi204N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi208N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi246N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication1
Glycosylationi256N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi259 ↔ 299PROSITE-ProRule annotation
Glycosylationi274N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi288N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi292N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi309N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi330N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi345 ↔ 393PROSITE-ProRule annotation
Glycosylationi351N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi360N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi375N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi432N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi437 ↔ 477PROSITE-ProRule annotation
Glycosylationi466N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi480N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi508N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi523 ↔ 571PROSITE-ProRule annotation
Glycosylationi529N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi553N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi560N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication1
Glycosylationi580N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi612N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi615 ↔ 655PROSITE-ProRule annotation
Glycosylationi650N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi665N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi685GPI-anchor amidated alanine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate.

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P06731

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P06731

MaxQB - The MaxQuant DataBase

More...MaxQBi		P06731

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P06731

PeptideAtlas

More...PeptideAtlasi		P06731

PRoteomics IDEntifications database

More...PRIDEi		P06731

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		46254
51917 [P06731-1]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1070, 14 N-Linked glycans (5 sites)
1071, 5 N-Linked glycans (3 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P06731, 28 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P06731

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P06731

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000105388, Expressed in colonic mucosa and 133 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P06731, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P06731, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000105388, Tissue enhanced (esophagus, intestine, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107478, 8 interactors

Database of interacting proteins

More...DIPi		DIP-57769N

Protein interaction database and analysis system

More...IntActi		P06731, 8 interactors

Molecular INTeraction database

More...MINTi		P06731

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000221992

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P06731, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1702
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P06731

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P06731

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 144Ig-like V-typeBy similarityAdd BLAST110
Domaini145 – 232Ig-like C2-type 1PROSITE-ProRule annotationAdd BLAST88
Domaini240 – 315Ig-like C2-type 2PROSITE-ProRule annotationAdd BLAST76
Domaini323 – 410Ig-like C2-type 3PROSITE-ProRule annotationAdd BLAST88
Domaini418 – 495Ig-like C2-type 4PROSITE-ProRule annotationAdd BLAST78
Domaini501 – 588Ig-like C2-type 5PROSITE-ProRule annotationAdd BLAST88
Domaini593 – 675Ig-like C2-type 6PROSITE-ProRule annotationAdd BLAST83

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RXPD, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_024555_7_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P06731

Database of Orthologous Groups

More...OrthoDBi		998214at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P06731

TreeFam database of animal gene trees

More...TreeFami		TF336859

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13895, Ig_2, 3 hits
PF07686, V-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 7 hits
SM00408, IGc2, 6 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 7 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P06731-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MESPSAPPHR WCIPWQRLLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE 
        60         70         80         90        100
VLLLVHNLPQ HLFGYSWYKG ERVDGNRQII GYVIGTQQAT PGPAYSGREI 
       110        120        130        140        150
IYPNASLLIQ NIIQNDTGFY TLHVIKSDLV NEEATGQFRV YPELPKPSIS 
       160        170        180        190        200
SNNSKPVEDK DAVAFTCEPE TQDATYLWWV NNQSLPVSPR LQLSNGNRTL 
       210        220        230        240        250
TLFNVTRNDT ASYKCETQNP VSARRSDSVI LNVLYGPDAP TISPLNTSYR 
       260        270        280        290        300
SGENLNLSCH AASNPPAQYS WFVNGTFQQS TQELFIPNIT VNNSGSYTCQ 
       310        320        330        340        350
AHNSDTGLNR TTVTTITVYA EPPKPFITSN NSNPVEDEDA VALTCEPEIQ 
       360        370        380        390        400
NTTYLWWVNN QSLPVSPRLQ LSNDNRTLTL LSVTRNDVGP YECGIQNKLS 
       410        420        430        440        450
VDHSDPVILN VLYGPDDPTI SPSYTYYRPG VNLSLSCHAA SNPPAQYSWL 
       460        470        480        490        500
IDGNIQQHTQ ELFISNITEK NSGLYTCQAN NSASGHSRTT VKTITVSAEL 
       510        520        530        540        550
PKPSISSNNS KPVEDKDAVA FTCEPEAQNT TYLWWVNGQS LPVSPRLQLS 
       560        570        580        590        600
NGNRTLTLFN VTRNDARAYV CGIQNSVSAN RSDPVTLDVL YGPDTPIISP 
       610        620        630        640        650
PDSSYLSGAN LNLSCHSASN PSPQYSWRIN GIPQQHTQVL FIAKITPNNN 
       660        670        680        690        700
GTYACFVSNL ATGRNNSIVK SITVSASGTS PGLSAGATVG IMIGVLVGVA 

LI
Length:702
Mass (Da):76,795
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i86318E244155DB58
GO
Isoform 2 (identifier: P06731-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     320-320: Missing.

Show »
Length:701
Mass (Da):76,724
Checksum:i19149D8E5BDE18E5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A024R0K5A0A024R0K5_HUMAN
Carcinoembryonic antigen-related ce...
CEACAM5 hCG_1642477
702Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYX0A0A087WYX0_HUMAN
Carcinoembryonic antigen-related ce...
CEACAM5
524Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
T2HUW8T2HUW8_HUMAN
Carcinoembryonic antigen-related ce...
CEACAM5
346Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QX98M0QX98_HUMAN
Carcinoembryonic antigen-related ce...
CEACAM5
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R3J1M0R3J1_HUMAN
Carcinoembryonic antigen-related ce...
CEACAM5
194Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA62835 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti641F → L in AAA62835 (PubMed:2342461).Curated1
Sequence conflicti646T → Q in AAA62835 (PubMed:2342461).Curated1
Sequence conflicti689V → A in AAA62835 (PubMed:2342461).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06131080I → V. Corresponds to variant dbSNP:rs12971352EnsemblClinVar.1
Natural variantiVAR_06131183V → A. Corresponds to variant dbSNP:rs28683503EnsemblClinVar.1
Natural variantiVAR_056028137Q → P. Corresponds to variant dbSNP:rs3815780Ensembl.1
Natural variantiVAR_031091340A → D. Corresponds to variant dbSNP:rs10407503Ensembl.1
Natural variantiVAR_024493398K → E5 PublicationsCorresponds to variant dbSNP:rs7249230Ensembl.1
Natural variantiVAR_031092664R → S. Corresponds to variant dbSNP:rs10423171Ensembl.1
Natural variantiVAR_056029678G → R. Corresponds to variant dbSNP:rs9621Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_053414320Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M17303 Genomic DNA Translation: AAB59513.1
M29540 mRNA Translation: AAA51967.1
M59262 M59261 Genomic DNA Translation: AAA62835.1 Frameshift.
M59709 Genomic DNA No translation available.
M59710 Genomic DNA No translation available.
AC008999 Genomic DNA No translation available.
X16455 mRNA Translation: CAA34474.1
M15042 mRNA Translation: AAA51963.1
M16234 mRNA Translation: AAA51972.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12584.1 [P06731-1]
CCDS77302.1 [P06731-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A36319

NCBI Reference Sequences

More...RefSeqi		NP_001278413.1, NM_001291484.2
NP_001295327.1, NM_001308398.1
NP_004354.3, NM_004363.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000221992; ENSP00000221992; ENSG00000105388
ENST00000398599; ENSP00000381600; ENSG00000105388
ENST00000405816; ENSP00000385072; ENSG00000105388

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1048

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1048

UCSC genome browser

More...UCSCi		uc002orj.2, human [P06731-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17303 Genomic DNA Translation: AAB59513.1
M29540 mRNA Translation: AAA51967.1
M59262 M59261 Genomic DNA Translation: AAA62835.1 Frameshift.
M59709 Genomic DNA No translation available.
M59710 Genomic DNA No translation available.
AC008999 Genomic DNA No translation available.
X16455 mRNA Translation: CAA34474.1
M15042 mRNA Translation: AAA51963.1
M16234 mRNA Translation: AAA51972.1
CCDSiCCDS12584.1 [P06731-1]
CCDS77302.1 [P06731-2]
PIRiA36319
RefSeqiNP_001278413.1, NM_001291484.2
NP_001295327.1, NM_001308398.1
NP_004354.3, NM_004363.5

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E07X-ray-A35-676[»]
2QSQX-ray1.95A/B34-144[»]
2QSTX-ray2.90A/B34-144[»]
2VERNMR-N35-144[»]
SMRiP06731
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107478, 8 interactors
DIPiDIP-57769N
IntActiP06731, 8 interactors
MINTiP06731
STRINGi9606.ENSP00000221992

Chemistry databases

ChEMBLiCHEMBL3712881
DrugBankiDB05097, Labetuzumab
DB08217, S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate

PTM databases

GlyConnecti1070, 14 N-Linked glycans (5 sites)
1071, 5 N-Linked glycans (3 sites)
GlyGeniP06731, 28 sites
iPTMnetiP06731
PhosphoSitePlusiP06731

Polymorphism and mutation databases

BioMutaiCEACAM5
DMDMi317373456

Proteomic databases

jPOSTiP06731
MassIVEiP06731
MaxQBiP06731
PaxDbiP06731
PeptideAtlasiP06731
PRIDEiP06731
ProteomicsDBi46254
51917 [P06731-1]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P06731, 39 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3500, 3216 antibodies

The DNASU plasmid repository

More...DNASUi		1048

Genome annotation databases

EnsembliENST00000221992; ENSP00000221992; ENSG00000105388
ENST00000398599; ENSP00000381600; ENSG00000105388
ENST00000405816; ENSP00000385072; ENSG00000105388
GeneIDi1048
KEGGihsa:1048
UCSCiuc002orj.2, human [P06731-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1048
DisGeNETi1048
EuPathDBiHostDB:ENSG00000105388.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		CEACAM5
HGNCiHGNC:1817, CEACAM5
HPAiENSG00000105388, Tissue enhanced (esophagus, intestine, lymphoid tissue)
MIMi114890, gene
neXtProtiNX_P06731
PharmGKBiPA26361

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RXPD, Eukaryota
HOGENOMiCLU_024555_7_0_1
InParanoidiP06731
OrthoDBi998214at2759
PhylomeDBiP06731
TreeFamiTF336859

Enzyme and pathway databases

PathwayCommonsiP06731
ReactomeiR-HSA-163125, Post-translational modification: synthesis of GPI-anchored proteins
R-HSA-202733, Cell surface interactions at the vascular wall

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1048, 15 hits in 845 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CEACAM5, human
EvolutionaryTraceiP06731

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CEACAM5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1048
PharosiP06731, Tbio

Protein Ontology

More...PROi		PR:P06731
RNActiP06731, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000105388, Expressed in colonic mucosa and 133 other tissues
ExpressionAtlasiP06731, baseline and differential
GenevisibleiP06731, HS

Family and domain databases

Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR013106, Ig_V-set
PfamiView protein in Pfam
PF13895, Ig_2, 3 hits
PF07686, V-set, 1 hit
SMARTiView protein in SMART
SM00409, IG, 7 hits
SM00408, IGc2, 6 hits
SUPFAMiSSF48726, SSF48726, 7 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCEAM5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06731
Secondary accession number(s): H9KVA7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 11, 2011
Last modified: December 2, 2020
This is version 199 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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