UniProtKB - P06731 (CEAM5_HUMAN)
Carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM5
Functioni
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933).
Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308).
Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).
3 Publications(Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.
1 PublicationGO - Molecular functioni
- GPI anchor binding Source: UniProtKB
- identical protein binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: UniProtKB
- homophilic cell adhesion via plasma membrane adhesion molecules Source: UniProtKB
- homotypic cell-cell adhesion Source: UniProtKB
- negative regulation of anoikis Source: UniProtKB
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of myotube differentiation Source: UniProtKB
Keywordsi
Biological process | Apoptosis, Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | P06731 |
Reactomei | R-HSA-163125, Post-translational modification: synthesis of GPI-anchored proteins R-HSA-202733, Cell surface interactions at the vascular wall |
SignaLinki | P06731 |
Names & Taxonomyi
Protein namesi | Recommended name: Carcinoembryonic antigen-related cell adhesion molecule 5Alternative name(s): Carcinoembryonic antigen Short name: CEA Meconium antigen 100 CD_antigen: CD66e |
Gene namesi | Name:CEACAM5 Synonyms:CEA |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1817, CEACAM5 |
MIMi | 114890, gene |
neXtProti | NX_P06731 |
VEuPathDBi | HostDB:ENSG00000105388 |
Subcellular locationi
Plasma membrane
- Cell membrane 3 Publications; GPI-anchor 3 Publications
- Apical cell membrane 1 Publication
Other locations
- Cell surface 2 Publications
Note: Localized to the apical glycocalyx surface.1 Publication
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- basolateral plasma membrane Source: UniProtKB
- integral component of external side of plasma membrane Source: UniProtKB
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: HPA
Other locations
- anchored component of membrane Source: UniProtKB
- cell surface Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 63 | F → I: No effect on dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication | 1 | |
Mutagenesisi | 63 | F → R: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication | 1 | |
Mutagenesisi | 66 | S → N: Abolishes dimerization. 2 Publications | 1 | |
Mutagenesisi | 68 | Y → A: Abolishes dimerization. 1 Publication | 1 | |
Mutagenesisi | 68 | Y → F: No effect on dimerization. 1 Publication | 1 | |
Mutagenesisi | 69 | K → A: Abolishes dimerization. 1 Publication | 1 | |
Mutagenesisi | 73 | V → A: Abolishes dimerization. 1 Publication | 1 | |
Mutagenesisi | 74 | D → A: No effect on dimerization. 1 Publication | 1 | |
Mutagenesisi | 74 | D → L or R: Abolishes dimerization. 1 Publication | 1 | |
Mutagenesisi | 78 | Q → L or R: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 2 Publications | 1 | |
Mutagenesisi | 125 | I → A: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication | 1 | |
Mutagenesisi | 129 | L → A or C: No effect on dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication | 1 | |
Mutagenesisi | 129 | L → S: Abolishes dimerization. Reduced affinity for E.coli Dr adhesins. 1 Publication | 1 | |
Mutagenesisi | 133 | E → A: Abolishes dimerization. 1 Publication | 1 |
Keywords - Diseasei
OncogeneOrganism-specific databases
DisGeNETi | 1048 |
PharmGKBi | PA26361 |
Miscellaneous databases
Pharosi | P06731, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3712881 |
DrugBanki | DB05097, Labetuzumab DB08217, S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate |
Genetic variation databases
BioMutai | CEACAM5 |
DMDMi | 317373456 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 34 | Add BLAST | 34 | |
ChainiPRO_0000014566 | 35 – 685 | Carcinoembryonic antigen-related cell adhesion molecule 5Add BLAST | 651 | |
PropeptideiPRO_0000014567 | 686 – 702 | Removed in mature formSequence analysisAdd BLAST | 17 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 104 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 115 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 152 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Disulfide bondi | 167 ↔ 215 | PROSITE-ProRule annotation | ||
Glycosylationi | 182 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 197 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 204 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 208 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 246 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication | 1 | |
Glycosylationi | 256 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Disulfide bondi | 259 ↔ 299 | PROSITE-ProRule annotation | ||
Glycosylationi | 274 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 288 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 292 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 309 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 330 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Disulfide bondi | 345 ↔ 393 | PROSITE-ProRule annotation | ||
Glycosylationi | 351 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 360 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 375 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 432 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Disulfide bondi | 437 ↔ 477 | PROSITE-ProRule annotation | ||
Glycosylationi | 466 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 480 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 508 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Disulfide bondi | 523 ↔ 571 | PROSITE-ProRule annotation | ||
Glycosylationi | 529 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 553 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 560 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication | 1 | |
Glycosylationi | 580 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 612 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Disulfide bondi | 615 ↔ 655 | PROSITE-ProRule annotation | ||
Glycosylationi | 650 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 665 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Lipidationi | 685 | GPI-anchor amidated alanine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, GPI-anchor, LipoproteinProteomic databases
jPOSTi | P06731 |
MassIVEi | P06731 |
MaxQBi | P06731 |
PaxDbi | P06731 |
PeptideAtlasi | P06731 |
PRIDEi | P06731 |
ProteomicsDBi | 46254 51917 [P06731-1] |
PTM databases
GlyConnecti | 1071, 257 N-Linked glycans (15 sites) |
GlyGeni | P06731, 29 sites, 155 N-linked glycans (15 sites) |
iPTMneti | P06731 |
PhosphoSitePlusi | P06731 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000105388, Expressed in colonic mucosa and 134 other tissues |
ExpressionAtlasi | P06731, baseline and differential |
Genevisiblei | P06731, HS |
Organism-specific databases
HPAi | ENSG00000105388, Tissue enriched (intestine) |
Interactioni
Subunit structurei
Homodimer.
2 PublicationsBinary interactionsi
P06731
With | #Exp. | IntAct |
---|---|---|
itself | 7 | EBI-3914938,EBI-3914938 |
S [K0BRG7] from Human betacoronavirus 2c EMC/2012. | 4 | EBI-3914938,EBI-16040613 |
GO - Molecular functioni
- identical protein binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107478, 12 interactors |
DIPi | DIP-57769N |
IntActi | P06731, 8 interactors |
MINTi | P06731 |
STRINGi | 9606.ENSP00000221992 |
Miscellaneous databases
RNActi | P06731, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P06731 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P06731 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 35 – 144 | Ig-like V-typeBy similarityAdd BLAST | 110 | |
Domaini | 145 – 232 | Ig-like C2-type 1PROSITE-ProRule annotationAdd BLAST | 88 | |
Domaini | 240 – 315 | Ig-like C2-type 2PROSITE-ProRule annotationAdd BLAST | 76 | |
Domaini | 323 – 410 | Ig-like C2-type 3PROSITE-ProRule annotationAdd BLAST | 88 | |
Domaini | 418 – 495 | Ig-like C2-type 4PROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 501 – 588 | Ig-like C2-type 5PROSITE-ProRule annotationAdd BLAST | 88 | |
Domaini | 593 – 675 | Ig-like C2-type 6PROSITE-ProRule annotationAdd BLAST | 83 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, SignalPhylogenomic databases
eggNOGi | ENOG502RXPD, Eukaryota |
HOGENOMi | CLU_024555_7_0_1 |
InParanoidi | P06731 |
OrthoDBi | 998214at2759 |
PhylomeDBi | P06731 |
TreeFami | TF336859 |
Family and domain databases
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF13895, Ig_2, 3 hits PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 7 hits SM00408, IGc2, 6 hits |
SUPFAMi | SSF48726, SSF48726, 7 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 6 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MESPSAPPHR WCIPWQRLLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE
60 70 80 90 100
VLLLVHNLPQ HLFGYSWYKG ERVDGNRQII GYVIGTQQAT PGPAYSGREI
110 120 130 140 150
IYPNASLLIQ NIIQNDTGFY TLHVIKSDLV NEEATGQFRV YPELPKPSIS
160 170 180 190 200
SNNSKPVEDK DAVAFTCEPE TQDATYLWWV NNQSLPVSPR LQLSNGNRTL
210 220 230 240 250
TLFNVTRNDT ASYKCETQNP VSARRSDSVI LNVLYGPDAP TISPLNTSYR
260 270 280 290 300
SGENLNLSCH AASNPPAQYS WFVNGTFQQS TQELFIPNIT VNNSGSYTCQ
310 320 330 340 350
AHNSDTGLNR TTVTTITVYA EPPKPFITSN NSNPVEDEDA VALTCEPEIQ
360 370 380 390 400
NTTYLWWVNN QSLPVSPRLQ LSNDNRTLTL LSVTRNDVGP YECGIQNELS
410 420 430 440 450
VDHSDPVILN VLYGPDDPTI SPSYTYYRPG VNLSLSCHAA SNPPAQYSWL
460 470 480 490 500
IDGNIQQHTQ ELFISNITEK NSGLYTCQAN NSASGHSRTT VKTITVSAEL
510 520 530 540 550
PKPSISSNNS KPVEDKDAVA FTCEPEAQNT TYLWWVNGQS LPVSPRLQLS
560 570 580 590 600
NGNRTLTLFN VTRNDARAYV CGIQNSVSAN RSDPVTLDVL YGPDTPIISP
610 620 630 640 650
PDSSYLSGAN LNLSCHSASN PSPQYSWRIN GIPQQHTQVL FIAKITPNNN
660 670 680 690 700
GTYACFVSNL ATGRNNSIVK SITVSASGTS PGLSAGATVG IMIGVLVGVA
LI
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A024R0K5 | A0A024R0K5_HUMAN | Carcinoembryonic antigen-related ce... | CEACAM5 hCG_1642477 | 702 | Annotation score: | ||
A0A087WYX0 | A0A087WYX0_HUMAN | Carcinoembryonic antigen-related ce... | CEACAM5 | 524 | Annotation score: | ||
T2HUW8 | T2HUW8_HUMAN | Carcinoembryonic antigen-related ce... | CEACAM5 | 346 | Annotation score: | ||
M0QX98 | M0QX98_HUMAN | Carcinoembryonic antigen-related ce... | CEACAM5 | 141 | Annotation score: | ||
M0R3J1 | M0R3J1_HUMAN | Carcinoembryonic antigen-related ce... | CEACAM5 | 194 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 641 | F → L in AAA62835 (PubMed:2342461).Curated | 1 | |
Sequence conflicti | 646 | T → Q in AAA62835 (PubMed:2342461).Curated | 1 | |
Sequence conflicti | 689 | V → A in AAA62835 (PubMed:2342461).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_061310 | 80 | I → V. Corresponds to variant dbSNP:rs12971352EnsemblClinVar. | 1 | |
Natural variantiVAR_061311 | 83 | V → A. Corresponds to variant dbSNP:rs28683503EnsemblClinVar. | 1 | |
Natural variantiVAR_056028 | 137 | Q → P. Corresponds to variant dbSNP:rs3815780Ensembl. | 1 | |
Natural variantiVAR_031091 | 340 | A → D. Corresponds to variant dbSNP:rs10407503Ensembl. | 1 | |
Natural variantiVAR_024493 | 398 | E → K. Corresponds to variant dbSNP:rs7249230Ensembl. | 1 | |
Natural variantiVAR_031092 | 664 | R → S. Corresponds to variant dbSNP:rs10423171Ensembl. | 1 | |
Natural variantiVAR_056029 | 678 | G → R. Corresponds to variant dbSNP:rs9621Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053414 | 320 | Missing in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M17303 Genomic DNA Translation: AAB59513.1 M29540 mRNA Translation: AAA51967.1 M59262 , M59255, M59256, M59257, M59258, M59259, M59260, M59261 Genomic DNA Translation: AAA62835.1 Frameshift. M59709 Genomic DNA No translation available. M59710 Genomic DNA No translation available. AC243967 Genomic DNA No translation available. X16455 mRNA Translation: CAA34474.1 M15042 mRNA Translation: AAA51963.1 M16234 mRNA Translation: AAA51972.1 |
CCDSi | CCDS12584.1 [P06731-1] CCDS77302.1 [P06731-2] |
PIRi | A36319 |
RefSeqi | NP_001278413.1, NM_001291484.2 NP_001295327.1, NM_001308398.1 NP_004354.3, NM_004363.5 |
Genome annotation databases
Ensembli | ENST00000221992; ENSP00000221992; ENSG00000105388 ENST00000398599; ENSP00000381600; ENSG00000105388 ENST00000405816; ENSP00000385072; ENSG00000105388 |
GeneIDi | 1048 |
KEGGi | hsa:1048 |
UCSCi | uc002orj.2, human [P06731-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M17303 Genomic DNA Translation: AAB59513.1 M29540 mRNA Translation: AAA51967.1 M59262 , M59255, M59256, M59257, M59258, M59259, M59260, M59261 Genomic DNA Translation: AAA62835.1 Frameshift. M59709 Genomic DNA No translation available. M59710 Genomic DNA No translation available. AC243967 Genomic DNA No translation available. X16455 mRNA Translation: CAA34474.1 M15042 mRNA Translation: AAA51963.1 M16234 mRNA Translation: AAA51972.1 |
CCDSi | CCDS12584.1 [P06731-1] CCDS77302.1 [P06731-2] |
PIRi | A36319 |
RefSeqi | NP_001278413.1, NM_001291484.2 NP_001295327.1, NM_001308398.1 NP_004354.3, NM_004363.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1E07 | X-ray | - | A | 35-676 | [»] | |
2QSQ | X-ray | 1.95 | A/B | 34-144 | [»] | |
2QST | X-ray | 2.90 | A/B | 34-144 | [»] | |
2VER | NMR | - | N | 35-144 | [»] | |
SMRi | P06731 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107478, 12 interactors |
DIPi | DIP-57769N |
IntActi | P06731, 8 interactors |
MINTi | P06731 |
STRINGi | 9606.ENSP00000221992 |
Chemistry databases
ChEMBLi | CHEMBL3712881 |
DrugBanki | DB05097, Labetuzumab DB08217, S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate |
PTM databases
GlyConnecti | 1071, 257 N-Linked glycans (15 sites) |
GlyGeni | P06731, 29 sites, 155 N-linked glycans (15 sites) |
iPTMneti | P06731 |
PhosphoSitePlusi | P06731 |
Genetic variation databases
BioMutai | CEACAM5 |
DMDMi | 317373456 |
Proteomic databases
jPOSTi | P06731 |
MassIVEi | P06731 |
MaxQBi | P06731 |
PaxDbi | P06731 |
PeptideAtlasi | P06731 |
PRIDEi | P06731 |
ProteomicsDBi | 46254 51917 [P06731-1] |
Protocols and materials databases
ABCDi | P06731, 39 sequenced antibodies |
Antibodypediai | 3500, 3744 antibodies from 52 providers |
DNASUi | 1048 |
Genome annotation databases
Ensembli | ENST00000221992; ENSP00000221992; ENSG00000105388 ENST00000398599; ENSP00000381600; ENSG00000105388 ENST00000405816; ENSP00000385072; ENSG00000105388 |
GeneIDi | 1048 |
KEGGi | hsa:1048 |
UCSCi | uc002orj.2, human [P06731-1] |
Organism-specific databases
CTDi | 1048 |
DisGeNETi | 1048 |
GeneCardsi | CEACAM5 |
HGNCi | HGNC:1817, CEACAM5 |
HPAi | ENSG00000105388, Tissue enriched (intestine) |
MIMi | 114890, gene |
neXtProti | NX_P06731 |
PharmGKBi | PA26361 |
VEuPathDBi | HostDB:ENSG00000105388 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RXPD, Eukaryota |
HOGENOMi | CLU_024555_7_0_1 |
InParanoidi | P06731 |
OrthoDBi | 998214at2759 |
PhylomeDBi | P06731 |
TreeFami | TF336859 |
Enzyme and pathway databases
PathwayCommonsi | P06731 |
Reactomei | R-HSA-163125, Post-translational modification: synthesis of GPI-anchored proteins R-HSA-202733, Cell surface interactions at the vascular wall |
SignaLinki | P06731 |
Miscellaneous databases
BioGRID-ORCSi | 1048, 23 hits in 1042 CRISPR screens |
ChiTaRSi | CEACAM5, human |
EvolutionaryTracei | P06731 |
GeneWikii | CEACAM5 |
GenomeRNAii | 1048 |
Pharosi | P06731, Tbio |
PROi | PR:P06731 |
RNActi | P06731, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105388, Expressed in colonic mucosa and 134 other tissues |
ExpressionAtlasi | P06731, baseline and differential |
Genevisiblei | P06731, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 7 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF13895, Ig_2, 3 hits PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 7 hits SM00408, IGc2, 6 hits |
SUPFAMi | SSF48726, SSF48726, 7 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CEAM5_HUMAN | |
Accessioni | P06731Primary (citable) accession number: P06731 Secondary accession number(s): H9KVA7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | February 23, 2022 | |
Last modified: | February 23, 2022 | |
This is version 204 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families