UniProtKB - P06730 (IF4E_HUMAN)
Eukaryotic translation initiation factor 4E
EIF4E
Functioni
Caution
GO - Molecular functioni
- enzyme binding Source: AgBase
- eukaryotic initiation factor 4G binding Source: AgBase
- repressing transcription factor binding Source: AgBase
- RNA 7-methylguanosine cap binding Source: UniProtKB
- RNA binding Source: UniProtKB
- RNA cap binding Source: ProtInc
- translation initiation factor activity Source: UniProtKB
GO - Biological processi
- behavioral fear response Source: Ensembl
- cellular response to dexamethasone stimulus Source: Ensembl
- G1/S transition of mitotic cell cycle Source: UniProtKB
- lung development Source: Ensembl
- mRNA export from nucleus Source: Reactome
- negative regulation of neuron differentiation Source: Ensembl
- negative regulation of translation Source: Ensembl
- positive regulation of mitotic cell cycle Source: UniProtKB
- regulation of translation Source: UniProtKB
- regulation of translation at postsynapse, modulating synaptic transmission Source: Ensembl
- RNA export from nucleus Source: Reactome
- stem cell population maintenance Source: Ensembl
- translational initiation Source: Reactome
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Initiation factor, RNA-binding |
Biological process | Host-virus interaction, Protein biosynthesis, Translation regulation |
Enzyme and pathway databases
PathwayCommonsi | P06730 |
Reactomei | R-HSA-1169408, ISG15 antiviral mechanism R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-159227, Transport of the SLBP independent Mature mRNA R-HSA-159230, Transport of the SLBP Dependant Mature mRNA R-HSA-159231, Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-166208, mTORC1-mediated signalling R-HSA-429947, Deadenylation of mRNA R-HSA-72649, Translation initiation complex formation R-HSA-72662, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72702, Ribosomal scanning and start codon recognition R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit |
SignaLinki | P06730 |
SIGNORi | P06730 |
Names & Taxonomyi
Protein namesi | Recommended name: Eukaryotic translation initiation factor 4E1 PublicationShort name: eIF-4E Short name: eIF4E Alternative name(s): eIF-4F 25 kDa subunit mRNA cap-binding protein1 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3287, EIF4E |
MIMi | 133440, gene |
neXtProti | NX_P06730 |
VEuPathDBi | HostDB:ENSG00000151247.12 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Cytoplasm and Cytosol
- Cytoplasm 2 Publications
Other locations
- P-body 4 Publications
- Stress granule 1 Publication
Note: Interaction with EIF4ENIF1/4E-T is required for localization to processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:25923732). Imported in the nucleus via interaction with EIF4ENIF1/4E-T via a piggy-back mechanism (PubMed:10856257).4 Publications
Cytosol
- cytosol Source: UniProtKB
- postsynaptic cytosol Source: Ensembl
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- chromatoid body Source: Ensembl
- cytoplasm Source: AgBase
- cytoplasmic ribonucleoprotein granule Source: HPA
- cytoplasmic stress granule Source: UniProtKB
- eukaryotic translation initiation factor 4F complex Source: UniProtKB
- glutamatergic synapse Source: Ensembl
- mRNA cap binding complex Source: UniProtKB
- P-body Source: UniProtKB
- perinuclear region of cytoplasm Source: AgBase
- RISC complex Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Autism 19 (AUTS19)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 53 | S → A or D: No effect on phosphorylation level nor incorporation into eIF4F complex. 2 Publications | 1 | |
Mutagenesisi | 73 | W → A: Abolishes binding to EIF4EBP1. Impairs interaction with DDX3X. 2 Publications | 1 | |
Mutagenesisi | 102 | W → L: Decrease in mRNA cap binding; when associated with A-105. 1 Publication | 1 | |
Mutagenesisi | 103 | E → A: No effect. 1 Publication | 1 | |
Mutagenesisi | 104 | D → A: No effect. 1 Publication | 1 | |
Mutagenesisi | 105 | E → A: Decrease in mRNA cap binding; when associated with L-102. 1 Publication | 1 | |
Mutagenesisi | 119 | K → A: Higher affinity for EIF4G1. 1 Publication | 1 | |
Mutagenesisi | 209 | S → A: Abolished resistance to cellular stress and DNA-damaging agents. 1 Publication | 1 | |
Mutagenesisi | 209 | S → D: Phosphomimetic mutant; confers resistance to cellular stress and DNA-damaging agents. 1 Publication | 1 |
Keywords - Diseasei
Autism, Autism spectrum disorderOrganism-specific databases
DisGeNETi | 1977 |
MalaCardsi | EIF4E |
MIMi | 615091, phenotype |
OpenTargetsi | ENSG00000151247 |
Orphaneti | 106, NON RARE IN EUROPE: Autism |
PharmGKBi | PA27714 |
Miscellaneous databases
Pharosi | P06730, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4848 |
DrugBanki | DB01960, 7-methyl-7,8-dihydroguanosine-5'-diphosphate DB01649, 7-methyl-GpppA DB02716, 7-methyl-guanosine-5'-triphosphate DB05165, LY2275796 DB08217, S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate |
DrugCentrali | P06730 |
Genetic variation databases
BioMutai | EIF4E |
DMDMi | 1352435 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000193634 | 2 – 217 | Eukaryotic translation initiation factor 4EAdd BLAST | 216 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 22 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 209 | Phosphoserine; by PKC and MKNK24 Publications | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P06730 |
jPOSTi | P06730 |
MassIVEi | P06730 |
MaxQBi | P06730 |
PeptideAtlasi | P06730 |
PRIDEi | P06730 |
ProteomicsDBi | 51914 [P06730-1] 51915 [P06730-2] 51916 [P06730-3] |
TopDownProteomicsi | P06730-1 [P06730-1] |
2D gel databases
OGPi | P06730 |
REPRODUCTION-2DPAGEi | IPI00027485 |
PTM databases
iPTMneti | P06730 |
MetOSitei | P06730 |
PhosphoSitePlusi | P06730 |
SwissPalmi | P06730 |
Expressioni
Gene expression databases
Bgeei | ENSG00000151247, Expressed in calcaneal tendon and 236 other tissues |
ExpressionAtlasi | P06730, baseline and differential |
Genevisiblei | P06730, HS |
Organism-specific databases
HPAi | ENSG00000151247, Low tissue specificity |
Interactioni
Subunit structurei
eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions (PubMed:11408474, PubMed:11879179, PubMed:16271312, PubMed:17631896). It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3 (PubMed:8521827, PubMed:11408474, PubMed:11879179, PubMed:12975586). EIF4E is also known to interact with other partners (PubMed:8521827, PubMed:11408474, PubMed:11879179, PubMed:12975586).
Interacts with EIF4ENIF1/4E-T; promotes recruitment to P-bodies and import into the nucleus (PubMed:10856257, PubMed:16157702, PubMed:23991149, PubMed:24335285, PubMed:28487484). Hypophosphorylated EIF4EBP1, EIF4EBP2 and EIF4EBP3 compete with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation (PubMed:8521827, PubMed:16271312, PubMed:21661078, PubMed:24207126, PubMed:25533957, PubMed:25702871).
Interacts mutually exclusive with EIF4A1 or EIF4A2 (PubMed:11408474).
Interacts with NGDN and PIWIL2 (By similarity).
Component of the CYFIP1-EIF4E-FMR1 complex composed of CYFIP, EIF4E and FMR1 (By similarity).
Interacts directly with CYFIP1 (By similarity).
Interacts with CLOCK (By similarity). Binds to MKNK2 in nucleus (PubMed:12897141).
Interacts with LIMD1, WTIP and AJUBA (PubMed:20616046).
Interacts with APOBEC3G in an RNA-dependent manner (PubMed:16699599).
Interacts with LARP1 (PubMed:20430826).
Interacts with METTL3 (PubMed:27117702).
Interacts with RBM24; this interaction prevents EIF4E from binding to p53/TP53 mRNA and inhibits the assembly of translation initiation complex (PubMed:29358667).
Interacts with DDX3X; interaction is direct and in an RNA-independent manner; this interaction enhances EIF4E cap-binding ability and is required for the repression of cap-dependent translation and the increase of IRES-mediated translation (PubMed:17667941, PubMed:21883093, PubMed:28733330). DDX3X competes with EIF4G1 for interaction with EIF4E (PubMed:17667941, PubMed:21883093).
By similarity24 Publications(Microbial infection) Interacts with Lassa virus Z protein.
1 PublicationBinary interactionsi
Hide detailsP06730
GO - Molecular functioni
- enzyme binding Source: AgBase
- eukaryotic initiation factor 4G binding Source: AgBase
- repressing transcription factor binding Source: AgBase
Protein-protein interaction databases
BioGRIDi | 108292, 81 interactors |
ComplexPortali | CPX-2666, Eukaryotic translation initiation factor 4F, EIF4A1 and EIF4G1 variant CPX-5634, Eukaryotic translation initiation factor 4F, EIF4A2 and EIF4G1 variant CPX-5635, Eukaryotic translation initiation factor 4F, EIF4A1 and EIF4G3 variant CPX-5636, Eukaryotic translation initiation factor 4F, EIF4A2 and EIF4G3 variant |
CORUMi | P06730 |
DIPi | DIP-22N |
ELMi | P06730 |
IntActi | P06730, 64 interactors |
MINTi | P06730 |
Chemistry databases
BindingDBi | P06730 |
Miscellaneous databases
RNActi | P06730, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P06730 |
SMRi | P06730 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P06730 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 37 – 40 | EIF4EBP1/2/3 binding1 Publication | 4 | |
Regioni | 56 – 57 | 7-methylguanosine-containing mRNA cap binding3 Publications | 2 | |
Regioni | 73 – 77 | EIF4EBP1/2/3 binding1 Publication | 5 | |
Regioni | 102 – 103 | 7-methylguanosine-containing mRNA cap binding3 Publications | 2 | |
Regioni | 132 – 139 | EIF4EBP1/2/3 binding1 Publication | 8 | |
Regioni | 157 – 162 | 7-methylguanosine-containing mRNA cap binding3 Publications | 6 | |
Regioni | 205 – 207 | 7-methylguanosine-containing mRNA cap binding3 Publications | 3 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000154194 |
HOGENOMi | CLU_043552_1_1_1 |
InParanoidi | P06730 |
OMAi | NDIRPEW |
OrthoDBi | 1394271at2759 |
PhylomeDBi | P06730 |
TreeFami | TF101526 |
Family and domain databases
Gene3Di | 3.30.760.10, 1 hit |
IDEALi | IID00341 |
InterProi | View protein in InterPro IPR023398, TIF_eIF4e-like IPR001040, TIF_eIF_4E IPR019770, TIF_eIF_4E_CS |
PANTHERi | PTHR11960, PTHR11960, 1 hit |
Pfami | View protein in Pfam PF01652, IF4E, 1 hit |
SUPFAMi | SSF55418, SSF55418, 1 hit |
PROSITEi | View protein in PROSITE PS00813, IF4E, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATVEPETTP TPNPPTTEEE KTESNQEVAN PEHYIKHPLQ NRWALWFFKN
60 70 80 90 100
DKSKTWQANL RLISKFDTVE DFWALYNHIQ LSSNLMPGCD YSLFKDGIEP
110 120 130 140 150
MWEDEKNKRG GRWLITLNKQ QRRSDLDRFW LETLLCLIGE SFDDYSDDVC
160 170 180 190 200
GAVVNVRAKG DKIAIWTTEC ENREAVTHIG RVYKERLGLP PKIVIGYQSH
210
ADTATKSGST TKNRFVV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RBW1 | D6RBW1_HUMAN | Eukaryotic translation initiation f... | EIF4E | 245 | Annotation score: | ||
H0Y8J7 | H0Y8J7_HUMAN | Eukaryotic translation initiation f... | EIF4E | 155 | Annotation score: | ||
D6RFJ3 | D6RFJ3_HUMAN | Eukaryotic translation initiation f... | EIF4E | 42 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 127 | D → N in AAH12611 (PubMed:15489334).Curated | 1 |
Mass spectrometryi
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043591 | 1 – 6 | MATVEP → MLDLTSRGQVGTSRRMAEAA CSAHFL in isoform 3. 1 Publication | 6 | |
Alternative sequenceiVSP_042014 | 133 | T → TRWDLAMLPRLVSNFWPQVI LPLQPPKVLELQ in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M15353 mRNA Translation: AAC13647.1 AK300982 mRNA Translation: BAH13387.1 AC019131 Genomic DNA No translation available. AC093836 Genomic DNA No translation available. BC012611 mRNA Translation: AAH12611.1 BC035166 mRNA Translation: AAH35166.1 BC043226 mRNA Translation: AAH43226.1 BM849222 mRNA No translation available. |
CCDSi | CCDS34031.1 [P06730-1] CCDS47109.1 [P06730-3] CCDS54779.1 [P06730-2] |
PIRi | A26411 |
RefSeqi | NP_001124150.1, NM_001130678.2 [P06730-3] NP_001124151.1, NM_001130679.2 [P06730-2] NP_001317946.1, NM_001331017.1 NP_001959.1, NM_001968.4 [P06730-1] |
Genome annotation databases
Ensembli | ENST00000280892; ENSP00000280892; ENSG00000151247 [P06730-3] ENST00000450253; ENSP00000389624; ENSG00000151247 [P06730-1] ENST00000505992; ENSP00000425561; ENSG00000151247 [P06730-2] |
GeneIDi | 1977 |
KEGGi | hsa:1977 |
UCSCi | uc003hue.3, human [P06730-1] |
Keywords - Coding sequence diversityi
Alternative splicing, Chromosomal rearrangementSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M15353 mRNA Translation: AAC13647.1 AK300982 mRNA Translation: BAH13387.1 AC019131 Genomic DNA No translation available. AC093836 Genomic DNA No translation available. BC012611 mRNA Translation: AAH12611.1 BC035166 mRNA Translation: AAH35166.1 BC043226 mRNA Translation: AAH43226.1 BM849222 mRNA No translation available. |
CCDSi | CCDS34031.1 [P06730-1] CCDS47109.1 [P06730-3] CCDS54779.1 [P06730-2] |
PIRi | A26411 |
RefSeqi | NP_001124150.1, NM_001130678.2 [P06730-3] NP_001124151.1, NM_001130679.2 [P06730-2] NP_001317946.1, NM_001331017.1 NP_001959.1, NM_001968.4 [P06730-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1IPB | X-ray | 2.00 | A | 1-217 | [»] | |
1IPC | X-ray | 2.00 | A | 1-217 | [»] | |
1WKW | X-ray | 2.10 | A | 27-217 | [»] | |
2GPQ | NMR | - | A | 1-217 | [»] | |
2V8W | X-ray | 2.30 | A/E | 1-217 | [»] | |
2V8X | X-ray | 2.30 | A/E | 1-217 | [»] | |
2V8Y | X-ray | 2.10 | A/E | 1-217 | [»] | |
2W97 | X-ray | 2.29 | A/B | 1-217 | [»] | |
3AM7 | X-ray | 2.20 | A | 27-217 | [»] | |
3TF2 | X-ray | 2.10 | A/B/C/D | 1-217 | [»] | |
3U7X | X-ray | 2.10 | A/B | 1-217 | [»] | |
4AZA | X-ray | 2.16 | A/C | 1-217 | [»] | |
4BEA | X-ray | 2.57 | A | 1-217 | [»] | |
4DT6 | X-ray | 2.60 | A | 1-217 | [»] | |
4DUM | X-ray | 2.95 | A | 1-217 | [»] | |
4TPW | X-ray | 1.50 | A/B | 28-217 | [»] | |
4TQB | X-ray | 1.59 | A/B | 28-217 | [»] | |
4TQC | X-ray | 1.80 | A/B | 28-217 | [»] | |
4UED | X-ray | 1.75 | A | 36-217 | [»] | |
5EHC | X-ray | 2.40 | A | 1-217 | [»] | |
5EI3 | X-ray | 1.71 | A | 1-217 | [»] | |
5EIR | X-ray | 2.69 | A | 1-217 | [»] | |
5EKV | X-ray | 3.61 | A/C | 1-217 | [»] | |
5GW6 | X-ray | 1.97 | A | 23-217 | [»] | |
5T46 | X-ray | 1.53 | A/C | 1-217 | [»] | |
5ZJY | X-ray | 1.59 | A | 28-217 | [»] | |
5ZJZ | X-ray | 1.67 | A | 28-217 | [»] | |
5ZK5 | X-ray | 2.25 | A | 28-217 | [»] | |
5ZK7 | X-ray | 2.12 | A/B | 28-217 | [»] | |
5ZK9 | X-ray | 1.76 | A | 28-217 | [»] | |
5ZML | X-ray | 1.80 | A | 27-217 | [»] | |
BMRBi | P06730 | |||||
SMRi | P06730 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108292, 81 interactors |
ComplexPortali | CPX-2666, Eukaryotic translation initiation factor 4F, EIF4A1 and EIF4G1 variant CPX-5634, Eukaryotic translation initiation factor 4F, EIF4A2 and EIF4G1 variant CPX-5635, Eukaryotic translation initiation factor 4F, EIF4A1 and EIF4G3 variant CPX-5636, Eukaryotic translation initiation factor 4F, EIF4A2 and EIF4G3 variant |
CORUMi | P06730 |
DIPi | DIP-22N |
ELMi | P06730 |
IntActi | P06730, 64 interactors |
MINTi | P06730 |
Chemistry databases
BindingDBi | P06730 |
ChEMBLi | CHEMBL4848 |
DrugBanki | DB01960, 7-methyl-7,8-dihydroguanosine-5'-diphosphate DB01649, 7-methyl-GpppA DB02716, 7-methyl-guanosine-5'-triphosphate DB05165, LY2275796 DB08217, S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate |
DrugCentrali | P06730 |
PTM databases
iPTMneti | P06730 |
MetOSitei | P06730 |
PhosphoSitePlusi | P06730 |
SwissPalmi | P06730 |
Genetic variation databases
BioMutai | EIF4E |
DMDMi | 1352435 |
2D gel databases
OGPi | P06730 |
REPRODUCTION-2DPAGEi | IPI00027485 |
Proteomic databases
EPDi | P06730 |
jPOSTi | P06730 |
MassIVEi | P06730 |
MaxQBi | P06730 |
PeptideAtlasi | P06730 |
PRIDEi | P06730 |
ProteomicsDBi | 51914 [P06730-1] 51915 [P06730-2] 51916 [P06730-3] |
TopDownProteomicsi | P06730-1 [P06730-1] |
Protocols and materials databases
Antibodypediai | 3421, 953 antibodies |
DNASUi | 1977 |
Genome annotation databases
Ensembli | ENST00000280892; ENSP00000280892; ENSG00000151247 [P06730-3] ENST00000450253; ENSP00000389624; ENSG00000151247 [P06730-1] ENST00000505992; ENSP00000425561; ENSG00000151247 [P06730-2] |
GeneIDi | 1977 |
KEGGi | hsa:1977 |
UCSCi | uc003hue.3, human [P06730-1] |
Organism-specific databases
CTDi | 1977 |
DisGeNETi | 1977 |
GeneCardsi | EIF4E |
HGNCi | HGNC:3287, EIF4E |
HPAi | ENSG00000151247, Low tissue specificity |
MalaCardsi | EIF4E |
MIMi | 133440, gene 615091, phenotype |
neXtProti | NX_P06730 |
OpenTargetsi | ENSG00000151247 |
Orphaneti | 106, NON RARE IN EUROPE: Autism |
PharmGKBi | PA27714 |
VEuPathDBi | HostDB:ENSG00000151247.12 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154194 |
HOGENOMi | CLU_043552_1_1_1 |
InParanoidi | P06730 |
OMAi | NDIRPEW |
OrthoDBi | 1394271at2759 |
PhylomeDBi | P06730 |
TreeFami | TF101526 |
Enzyme and pathway databases
PathwayCommonsi | P06730 |
Reactomei | R-HSA-1169408, ISG15 antiviral mechanism R-HSA-156827, L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-159227, Transport of the SLBP independent Mature mRNA R-HSA-159230, Transport of the SLBP Dependant Mature mRNA R-HSA-159231, Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-166208, mTORC1-mediated signalling R-HSA-429947, Deadenylation of mRNA R-HSA-72649, Translation initiation complex formation R-HSA-72662, Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72702, Ribosomal scanning and start codon recognition R-HSA-72706, GTP hydrolysis and joining of the 60S ribosomal subunit |
SignaLinki | P06730 |
SIGNORi | P06730 |
Miscellaneous databases
BioGRID-ORCSi | 1977, 728 hits in 973 CRISPR screens |
ChiTaRSi | EIF4E, human |
EvolutionaryTracei | P06730 |
GeneWikii | EIF4E |
GenomeRNAii | 1977 |
Pharosi | P06730, Tchem |
PROi | PR:P06730 |
RNActi | P06730, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000151247, Expressed in calcaneal tendon and 236 other tissues |
ExpressionAtlasi | P06730, baseline and differential |
Genevisiblei | P06730, HS |
Family and domain databases
Gene3Di | 3.30.760.10, 1 hit |
IDEALi | IID00341 |
InterProi | View protein in InterPro IPR023398, TIF_eIF4e-like IPR001040, TIF_eIF_4E IPR019770, TIF_eIF_4E_CS |
PANTHERi | PTHR11960, PTHR11960, 1 hit |
Pfami | View protein in Pfam PF01652, IF4E, 1 hit |
SUPFAMi | SSF55418, SSF55418, 1 hit |
PROSITEi | View protein in PROSITE PS00813, IF4E, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IF4E_HUMAN | |
Accessioni | P06730Primary (citable) accession number: P06730 Secondary accession number(s): B7Z6V1, D6RCQ6, Q96E95 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | February 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 227 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Translation initiation factors
List of translation initiation factor entries - Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families