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Entry version 218 (13 Nov 2019)
Sequence version 2 (01 Feb 1996)
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Protein

Eukaryotic translation initiation factor 4E

Gene

EIF4E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.2 Publications

Caution

Was originally thought to be phosphorylated on Ser-53 (PubMed:3112145); this was later shown to be wrong (PubMed:7665584).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processHost-virus interaction, Protein biosynthesis, Translation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-166208 mTORC1-mediated signalling
R-HSA-429947 Deadenylation of mRNA
R-HSA-72649 Translation initiation complex formation
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P06730

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P06730

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E
Short name:
eIF-4E
Short name:
eIF4E
Alternative name(s):
eIF-4F 25 kDa subunit
mRNA cap-binding protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EIF4E
Synonyms:EIF4EL1, EIF4F
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3287 EIF4E

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
133440 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P06730

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Autism 19 (AUTS19)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry. A heterozygous single-nucleotide insertion has been found in families affected by autism. The variant results in increased promoter activity and is involved in disease pathogenesis through EIF4E deregulation (PubMed:19556253).1 Publication
Disease descriptionA complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.
Related information in OMIM
A chromosomal aberration involving EIF4E has been found in a patient with classic autism. Translocation t(45)(q23q31.3). The breakpoint on chromosome 4 is located 56 kb downstream of EIF4E (PubMed:19556253).1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi53S → A or D: No effect on phosphorylation level nor incorporation into eIF4F complex. 2 Publications1
Mutagenesisi73W → A: Abolishes binding to EIF4EBP1. 1 Publication1
Mutagenesisi102W → L: Decrease in mRNA cap binding; when associated with A-105. 1 Publication1
Mutagenesisi103E → A: No effect. 1 Publication1
Mutagenesisi104D → A: No effect. 1 Publication1
Mutagenesisi105E → A: Decrease in mRNA cap binding; when associated with L-102. 1 Publication1
Mutagenesisi119K → A: Higher affinity for EIF4G1. 1 Publication1

Keywords - Diseasei

Autism, Autism spectrum disorder

Organism-specific databases

DisGeNET

More...
DisGeNETi
1977

MalaCards human disease database

More...
MalaCardsi
EIF4E
MIMi615091 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000151247

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
106 NON RARE IN EUROPE: Autism

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27714

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P06730

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4848

Drug and drug target database

More...
DrugBanki
DB01649 7-methyl-GpppA
DB02716 7-Methyl-Guanosine-5'-Triphosphate
DB01960 7n-Methyl-8-Hydroguanosine-5'-Diphosphate
DB05165 LY2275796
DB08217 S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate

DrugCentral

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DrugCentrali
P06730

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EIF4E

Domain mapping of disease mutations (DMDM)

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DMDMi
1352435

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001936342 – 217Eukaryotic translation initiation factor 4EAdd BLAST216

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei22PhosphothreonineCombined sources1
Modified residuei209Phosphoserine; by PKC and MKNK23 Publications1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex.7 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P06730

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P06730

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
P06730

MaxQB - The MaxQuant DataBase

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MaxQBi
P06730

PeptideAtlas

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PeptideAtlasi
P06730

PRoteomics IDEntifications database

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PRIDEi
P06730

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
51914 [P06730-1]
51915 [P06730-2]
51916 [P06730-3]

Consortium for Top Down Proteomics

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TopDownProteomicsi
P06730-1 [P06730-1]

2D gel databases

USC-OGP 2-DE database

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OGPi
P06730

REPRODUCTION-2DPAGE

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REPRODUCTION-2DPAGEi
IPI00027485

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P06730

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P06730

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P06730

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000151247 Expressed in 221 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P06730 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P06730 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004077
CAB016316
HPA051311

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4E is also known to interact with other partners. The interaction with EIF4ENIF1 mediates the import into the nucleus. Hypophosphorylated EIF4EBP1, EIF4EBP2 and EIF4EBP3 compete with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation (PubMed:24207126, PubMed:25533957, PubMed:21661078). Rapamycin can attenuate insulin stimulation, mediated by FKBPs.

Interacts mutually exclusive with EIF4A1 or EIF4A2.

Interacts with NGDN and PIWIL2.

Component of the CYFIP1-EIF4E-FMR1 complex composed of CYFIP, EIF4E and FMR1.

Interacts directly with CYFIP1.

Interacts with CLOCK (By similarity). Binds to MKNK2 in nucleus.

Interacts with LIMD1, WTIP and AJUBA.

Interacts with APOBEC3G in an RNA-dependent manner.

Interacts with LARP1.

Interacts with METTL3 (PubMed:27117702).

Interacts with RBM24; this interaction prevents EIF4E from binding to p53/TP53 mRNA and inhibits the assembly of translation initiation complex (PubMed:29358667).

By similarity15 Publications

(Microbial infection) Interacts with Lassa virus Z protein.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
108292, 64 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P06730

Database of interacting proteins

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DIPi
DIP-22N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P06730

Protein interaction database and analysis system

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IntActi
P06730, 50 interactors

Molecular INTeraction database

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MINTi
P06730

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P06730

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1217
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P06730

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P06730

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni37 – 40EIF4EBP1/2/3 binding4
Regioni56 – 577-methylguanosine-containing mRNA cap binding2
Regioni73 – 77EIF4EBP1/2/3 binding5
Regioni102 – 1037-methylguanosine-containing mRNA cap binding2
Regioni132 – 139EIF4EBP1/2/3 binding8
Regioni157 – 1627-methylguanosine-containing mRNA cap binding6
Regioni205 – 2077-methylguanosine-containing mRNA cap binding3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Ensembl GeneTree

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GeneTreei
ENSGT00940000154194

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000186751

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P06730

KEGG Orthology (KO)

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KOi
K03259

Identification of Orthologs from Complete Genome Data

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OMAi
NDIRPEW

Database of Orthologous Groups

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OrthoDBi
1394271at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P06730

TreeFam database of animal gene trees

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TreeFami
TF101526

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.760.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR023398 TIF_eIF4e-like
IPR001040 TIF_eIF_4E
IPR019770 TIF_eIF_4E_CS

The PANTHER Classification System

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PANTHERi
PTHR11960 PTHR11960, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01652 IF4E, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF55418 SSF55418, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00813 IF4E, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P06730-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATVEPETTP TPNPPTTEEE KTESNQEVAN PEHYIKHPLQ NRWALWFFKN
60 70 80 90 100
DKSKTWQANL RLISKFDTVE DFWALYNHIQ LSSNLMPGCD YSLFKDGIEP
110 120 130 140 150
MWEDEKNKRG GRWLITLNKQ QRRSDLDRFW LETLLCLIGE SFDDYSDDVC
160 170 180 190 200
GAVVNVRAKG DKIAIWTTEC ENREAVTHIG RVYKERLGLP PKIVIGYQSH
210
ADTATKSGST TKNRFVV
Length:217
Mass (Da):25,097
Last modified:February 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB869B8DE615E699D
GO
Isoform 2 (identifier: P06730-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     133-133: T → TRWDLAMLPRLVSNFWPQVILPLQPPKVLELQ

Note: No experimental confirmation available.
Show »
Length:248
Mass (Da):28,778
Checksum:i3869E3249A241190
GO
Isoform 3 (identifier: P06730-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MATVEP → MLDLTSRGQVGTSRRMAEAACSAHFL

Note: No experimental confirmation available.
Show »
Length:237
Mass (Da):27,260
Checksum:iD4925235C678DE08
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RBW1D6RBW1_HUMAN
Eukaryotic translation initiation f...
EIF4E
245Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8J7H0Y8J7_HUMAN
Eukaryotic translation initiation f...
EIF4E
155Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RFJ3D6RFJ3_HUMAN
Eukaryotic translation initiation f...
EIF4E
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti127D → N in AAH12611 (PubMed:15489334).Curated1

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 24964.3 Da from positions 2 - 217. Determined by ESI. 1 Publication
Molecular mass is 24960 Da from positions 2 - 217. Determined by ESI. 1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0435911 – 6MATVEP → MLDLTSRGQVGTSRRMAEAA CSAHFL in isoform 3. 1 Publication6
Alternative sequenceiVSP_042014133T → TRWDLAMLPRLVSNFWPQVI LPLQPPKVLELQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M15353 mRNA Translation: AAC13647.1
AK300982 mRNA Translation: BAH13387.1
AC019131 Genomic DNA No translation available.
AC093836 Genomic DNA No translation available.
BC012611 mRNA Translation: AAH12611.1
BC035166 mRNA Translation: AAH35166.1
BC043226 mRNA Translation: AAH43226.1
BM849222 mRNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS34031.1 [P06730-1]
CCDS47109.1 [P06730-3]
CCDS54779.1 [P06730-2]

Protein sequence database of the Protein Information Resource

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PIRi
A26411

NCBI Reference Sequences

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RefSeqi
NP_001124150.1, NM_001130678.2 [P06730-3]
NP_001124151.1, NM_001130679.2 [P06730-2]
NP_001317946.1, NM_001331017.1
NP_001959.1, NM_001968.4 [P06730-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000280892; ENSP00000280892; ENSG00000151247 [P06730-3]
ENST00000450253; ENSP00000389624; ENSG00000151247 [P06730-1]
ENST00000505992; ENSP00000425561; ENSG00000151247 [P06730-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
1977

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1977

UCSC genome browser

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UCSCi
uc003hue.3 human [P06730-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15353 mRNA Translation: AAC13647.1
AK300982 mRNA Translation: BAH13387.1
AC019131 Genomic DNA No translation available.
AC093836 Genomic DNA No translation available.
BC012611 mRNA Translation: AAH12611.1
BC035166 mRNA Translation: AAH35166.1
BC043226 mRNA Translation: AAH43226.1
BM849222 mRNA No translation available.
CCDSiCCDS34031.1 [P06730-1]
CCDS47109.1 [P06730-3]
CCDS54779.1 [P06730-2]
PIRiA26411
RefSeqiNP_001124150.1, NM_001130678.2 [P06730-3]
NP_001124151.1, NM_001130679.2 [P06730-2]
NP_001317946.1, NM_001331017.1
NP_001959.1, NM_001968.4 [P06730-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IPBX-ray2.00A1-217[»]
1IPCX-ray2.00A1-217[»]
1WKWX-ray2.10A27-217[»]
2GPQNMR-A1-217[»]
2V8WX-ray2.30A/E1-217[»]
2V8XX-ray2.30A/E1-217[»]
2V8YX-ray2.10A/E1-217[»]
2W97X-ray2.29A/B1-217[»]
3AM7X-ray2.20A27-217[»]
3TF2X-ray2.10A/B/C/D1-217[»]
3U7XX-ray2.10A/B1-217[»]
4AZAX-ray2.16A/C1-217[»]
4BEAX-ray2.57A1-217[»]
4DT6X-ray2.60A1-217[»]
4DUMX-ray2.95A1-217[»]
4TPWX-ray1.50A/B28-217[»]
4TQBX-ray1.59A/B28-217[»]
4TQCX-ray1.80A/B28-217[»]
4UEDX-ray1.75A36-217[»]
5EHCX-ray2.40A1-217[»]
5EI3X-ray1.71A1-217[»]
5EIRX-ray2.69A1-217[»]
5EKVX-ray3.61A/C1-217[»]
5GW6X-ray1.97A23-217[»]
5T46X-ray1.53A/C1-217[»]
5ZJYX-ray1.59A28-217[»]
5ZJZX-ray1.67A28-217[»]
5ZK5X-ray2.25A28-217[»]
5ZK7X-ray2.12A/B28-217[»]
5ZK9X-ray1.76A28-217[»]
5ZMLX-ray1.80A27-217[»]
SMRiP06730
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi108292, 64 interactors
CORUMiP06730
DIPiDIP-22N
ELMiP06730
IntActiP06730, 50 interactors
MINTiP06730

Chemistry databases

BindingDBiP06730
ChEMBLiCHEMBL4848
DrugBankiDB01649 7-methyl-GpppA
DB02716 7-Methyl-Guanosine-5'-Triphosphate
DB01960 7n-Methyl-8-Hydroguanosine-5'-Diphosphate
DB05165 LY2275796
DB08217 S-[(1-Hydroxy-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl] methanesulfonothioate
DrugCentraliP06730

PTM databases

iPTMnetiP06730
PhosphoSitePlusiP06730
SwissPalmiP06730

Polymorphism and mutation databases

BioMutaiEIF4E
DMDMi1352435

2D gel databases

OGPiP06730
REPRODUCTION-2DPAGEiIPI00027485

Proteomic databases

EPDiP06730
jPOSTiP06730
MassIVEiP06730
MaxQBiP06730
PeptideAtlasiP06730
PRIDEiP06730
ProteomicsDBi51914 [P06730-1]
51915 [P06730-2]
51916 [P06730-3]
TopDownProteomicsiP06730-1 [P06730-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1977

Genome annotation databases

EnsembliENST00000280892; ENSP00000280892; ENSG00000151247 [P06730-3]
ENST00000450253; ENSP00000389624; ENSG00000151247 [P06730-1]
ENST00000505992; ENSP00000425561; ENSG00000151247 [P06730-2]
GeneIDi1977
KEGGihsa:1977
UCSCiuc003hue.3 human [P06730-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1977
DisGeNETi1977

GeneCards: human genes, protein and diseases

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GeneCardsi
EIF4E
HGNCiHGNC:3287 EIF4E
HPAiCAB004077
CAB016316
HPA051311
MalaCardsiEIF4E
MIMi133440 gene
615091 phenotype
neXtProtiNX_P06730
OpenTargetsiENSG00000151247
Orphaneti106 NON RARE IN EUROPE: Autism
PharmGKBiPA27714

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000154194
HOGENOMiHOG000186751
InParanoidiP06730
KOiK03259
OMAiNDIRPEW
OrthoDBi1394271at2759
PhylomeDBiP06730
TreeFamiTF101526

Enzyme and pathway databases

ReactomeiR-HSA-1169408 ISG15 antiviral mechanism
R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-159227 Transport of the SLBP independent Mature mRNA
R-HSA-159230 Transport of the SLBP Dependant Mature mRNA
R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-HSA-166208 mTORC1-mediated signalling
R-HSA-429947 Deadenylation of mRNA
R-HSA-72649 Translation initiation complex formation
R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-HSA-72702 Ribosomal scanning and start codon recognition
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
SignaLinkiP06730
SIGNORiP06730

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
EIF4E human
EvolutionaryTraceiP06730

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
EIF4E

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1977
PharosiP06730

Protein Ontology

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PROi
PR:P06730

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000151247 Expressed in 221 organ(s), highest expression level in testis
ExpressionAtlasiP06730 baseline and differential
GenevisibleiP06730 HS

Family and domain databases

Gene3Di3.30.760.10, 1 hit
InterProiView protein in InterPro
IPR023398 TIF_eIF4e-like
IPR001040 TIF_eIF_4E
IPR019770 TIF_eIF_4E_CS
PANTHERiPTHR11960 PTHR11960, 1 hit
PfamiView protein in Pfam
PF01652 IF4E, 1 hit
SUPFAMiSSF55418 SSF55418, 1 hit
PROSITEiView protein in PROSITE
PS00813 IF4E, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIF4E_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06730
Secondary accession number(s): B7Z6V1, D6RCQ6, Q96E95
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: February 1, 1996
Last modified: November 13, 2019
This is version 218 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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