EIF4E

Functionⁱ

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit mediates the binding to the mRNA cap.2 Publications

Caution

Was originally thought to be phosphorylated on Ser-53 (PubMed:3112145); this was later shown to be wrong (PubMed:7665584).2 Publications

GO - Molecular functionⁱ

enzyme binding
Source: AgBase
Inferred from direct assayⁱ
- 23814182
eukaryotic initiation factor 4G binding
Source: AgBase
Inferred from direct assayⁱ
- 23814182
repressing transcription factor binding
Source: AgBase
Inferred from direct assayⁱ
- 23814182
RNA 7-methylguanosine cap binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19750007
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22681889
RNA cap binding
Source: ProtInc
Traceable author statementⁱ
- 3469651
translation initiation factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 22578813
translation regulator activity Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

behavioral fear response Source: Ensembl
cellular response to dexamethasone stimulus Source: Ensembl
G1/S transition of mitotic cell cycle
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 14673156
lung development Source: Ensembl
mRNA export from nucleus Source: Reactome
negative regulation of neuron differentiation Source: Ensembl
negative regulation of translation Source: Ensembl
positive regulation of mitotic cell cycle
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 14673156
regulation of translation
Source: UniProtKB
Inferred from direct assayⁱ
- 22578813
regulation of translation at postsynapse, modulating synaptic transmission Source: Ensembl
RNA export from nucleus Source: Reactome
stem cell population maintenance Source: Ensembl
translational initiation Source: Reactome
viral process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Initiation factor, RNA-binding
Biological process	Host-virus interaction, Protein biosynthesis, Translation regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1169408 ISG15 antiviral mechanism R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-159227 Transport of the SLBP independent Mature mRNA R-HSA-159230 Transport of the SLBP Dependant Mature mRNA R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-166208 mTORC1-mediated signalling R-HSA-429947 Deadenylation of mRNA R-HSA-72649 Translation initiation complex formation R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72702 Ribosomal scanning and start codon recognition R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
SignaLinkⁱ	P06730
SIGNORⁱ	P06730

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Eukaryotic translation initiation factor 4E Short name: eIF-4E Short name: eIF4E Alternative name(s): eIF-4F 25 kDa subunit mRNA cap-binding protein
Gene namesⁱ	Name:EIF4E Synonyms:EIF4EL1, EIF4F
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000151247.12
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3287 EIF4E
MIMⁱ	133440 gene
neXtProtⁱ	NX_P06730

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Autism 19 (AUTS19)1 Publication

Disease susceptibility is associated with variations affecting the gene represented in this entry. A heterozygous single-nucleotide insertion has been found in families affected by autism. The variant results in increased promoter activity and is involved in disease pathogenesis through EIF4E deregulation (PubMed:19556253).1 Publication

Disease descriptionA complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	53	S → A or D: No effect on phosphorylation level nor incorporation into eIF4F complex. 2 Publications	1
Mutagenesisⁱ	73	W → A: Abolishes binding to EIF4EBP1. 1 Publication	1
Mutagenesisⁱ	102	W → L: Decrease in mRNA cap binding; when associated with A-105. 1 Publication	1
Mutagenesisⁱ	103	E → A: No effect. 1 Publication	1
Mutagenesisⁱ	104	D → A: No effect. 1 Publication	1
Mutagenesisⁱ	105	E → A: Decrease in mRNA cap binding; when associated with L-102. 1 Publication	1
Mutagenesisⁱ	119	K → A: Higher affinity for EIF4G1. 1 Publication	1

Keywords - Diseaseⁱ

Autism, Autism spectrum disorder

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1977
MalaCards human disease database More...MalaCardsⁱ	EIF4E
MIMⁱ	615091 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000151247
Orphanetⁱ	106 Autism
PharmGKBⁱ	PA27714

Chemistry databases

ChEMBLⁱ	CHEMBL4848
Drug and drug target database More...DrugBankⁱ	DB01649 7-Methyl-Gpppa DB02716 7-Methyl-Guanosine-5'-Triphosphate DB01960 7n-Methyl-8-Hydroguanosine-5'-Diphosphate DB05165 LY2275796

Polymorphism and mutation databases

BioMutaⁱ	EIF4E
DMDMⁱ	1352435

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000193634	2 – 217	Eukaryotic translation initiation factor 4EAdd BLAST		216

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources	1
Modified residueⁱ	22	PhosphothreonineCombined sources	1
Modified residueⁱ	209	Phosphoserine; by PKC and MKNK23 Publications	1

Post-translational modificationⁱ

Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the eIF4F complex.7 Publications

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P06730
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P06730
PeptideAtlas More...PeptideAtlasⁱ	P06730
PRIDEⁱ	P06730
ProteomicsDBⁱ	51914 51915 [P06730-2] 51916 [P06730-3]
TopDownProteomicsⁱ	P06730-1 [P06730-1]

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P06730
REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00027485

PTM databases

iPTMnetⁱ	P06730
PhosphoSitePlusⁱ	P06730
SwissPalmⁱ	P06730

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000151247 Expressed in 221 organ(s), highest expression level in testis
CleanExⁱ	HS_EIF4E
ExpressionAtlasⁱ	P06730 baseline and differential
Genevisibleⁱ	P06730 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004077 CAB016316 HPA051311

HPAⁱ

CAB004077
CAB016316
HPA051311

Interactionⁱ

Subunit structureⁱ

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4E is also known to interact with other partners. The interaction with EIF4ENIF1 mediates the import into the nucleus. Hypophosphorylated EIF4EBP1, EIF4EBP2 and EIF4EBP3 compete with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation (PubMed:24207126, PubMed:25533957, PubMed:21661078). Rapamycin can attenuate insulin stimulation, mediated by FKBPs. Interacts mutually exclusive with EIF4A1 or EIF4A2. Interacts with NGDN and PIWIL2. Component of the CYFIP1-EIF4E-FMR1 complex composed of CYFIP, EIF4E and FMR1. Interacts directly with CYFIP1. Interacts with CLOCK (By similarity). Binds to MKNK2 in nucleus. Interacts with LIMD1, WTIP and AJUBA. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with LARP1. Interacts with METTL3 (PubMed:27117702). Interacts with RBM24; this interaction prevents EIF4E from binding to p53/TP53 mRNA and inhibits the assembly of translation initiation complex (PubMed:29358667).By similarity15 Publications

(Microbial infection) Interacts with Lassa virus Z protein.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Btg4	O70552	4	EBI-73440,EBI-16204405	From Mus musculus.
Cnot7	Q60809	2	EBI-73440,EBI-2104739	From Mus musculus.
EIF4EBP1	Q13541	21	EBI-73440,EBI-74090
EIF4EBP2	Q13542	8	EBI-73440,EBI-935137
EIF4EBP3	O60516	7	EBI-73440,EBI-746950
EIF4ENIF1	Q9NRA8	9	EBI-73440,EBI-301024
EIF4G1	Q04637	9	EBI-73440,EBI-73711
EIF4G3	O43432-1	2	EBI-73440,EBI-15841003
EMX2	Q04743	4	EBI-73440,EBI-399831
GEMIN5	Q8TEQ6	3	EBI-73440,EBI-443630
KANK2	Q63ZY3	5	EBI-73440,EBI-2556193
LRPPRC	P42704	6	EBI-73440,EBI-1050853
PABPC1	P11940	5	EBI-73440,EBI-81531
PPP2CA	P67775	2	EBI-73440,EBI-712311
SUMO1	P63165	5	EBI-73440,EBI-80140
TDO2	P48775	3	EBI-73440,EBI-743494
TRIM27	P14373	3	EBI-73440,EBI-719493
UBXN11	Q5T124	3	EBI-73440,EBI-746004
Z	O73557	3	EBI-73440,EBI-15840965	From Lassa virus (strain Mouse/Sierra Leone/Josiah/1976).

GO - Molecular functionⁱ

enzyme binding
Source: AgBase
Inferred from direct assayⁱ
- 23814182
eukaryotic initiation factor 4G binding
Source: AgBase
Inferred from direct assayⁱ
- 23814182
repressing transcription factor binding
Source: AgBase
Inferred from direct assayⁱ
- 23814182

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108292, 51 interactors
CORUMⁱ	P06730
Database of interacting proteins More...DIPⁱ	DIP-22N
ELMⁱ	P06730
IntActⁱ	P06730, 45 interactors
Molecular INTeraction database More...MINTⁱ	P06730

Chemistry databases

BindingDBⁱ

P06730

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	31 – 33	Combined sources	3
Beta strandⁱ	38 – 49	Combined sources	12
Beta strandⁱ	51 – 53	Combined sources	3
Helixⁱ	56 – 59	Combined sources	4
Beta strandⁱ	60 – 68	Combined sources	9
Helixⁱ	69 – 82	Combined sources	14
Beta strandⁱ	89 – 95	Combined sources	7
Beta strandⁱ	100 – 103	Combined sources	4
Turnⁱ	105 – 109	Combined sources	5
Beta strandⁱ	111 – 116	Combined sources	6
Helixⁱ	119 – 122	Combined sources	4
Turnⁱ	123 – 125	Combined sources	3
Helixⁱ	126 – 138	Combined sources	13
Turnⁱ	139 – 142	Combined sources	4
Helixⁱ	143 – 148	Combined sources	6
Beta strandⁱ	149 – 155	Combined sources	7
Beta strandⁱ	162 – 168	Combined sources	7
Helixⁱ	173 – 187	Combined sources	15
Beta strandⁱ	191 – 193	Combined sources	3
Beta strandⁱ	196 – 199	Combined sources	4
Helixⁱ	200 – 204	Combined sources	5
Beta strandⁱ	205 – 207	Combined sources	3
Turnⁱ	208 – 210	Combined sources	3
Beta strandⁱ	214 – 216	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P06730
SMRⁱ	P06730
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P06730

EvolutionaryTraceⁱ

P06730

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	37 – 40	EIF4EBP1/2/3 binding	4
Regionⁱ	56 – 57	7-methylguanosine-containing mRNA cap binding	2
Regionⁱ	73 – 77	EIF4EBP1/2/3 binding	5
Regionⁱ	102 – 103	7-methylguanosine-containing mRNA cap binding	2
Regionⁱ	132 – 139	EIF4EBP1/2/3 binding	8
Regionⁱ	157 – 162	7-methylguanosine-containing mRNA cap binding	6
Regionⁱ	205 – 207	7-methylguanosine-containing mRNA cap binding	3

Sequence similaritiesⁱ

Belongs to the eukaryotic initiation factor 4E family.Curated

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00520000055549
HOGENOMⁱ	HOG000186751
HOVERGENⁱ	HBG006130
InParanoidⁱ	P06730
KEGG Orthology (KO) More...KOⁱ	K03259
OMAⁱ	MKMTIGY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IVA
PhylomeDBⁱ	P06730
TreeFamⁱ	TF101526

Family and domain databases

Gene3Dⁱ	3.30.760.10, 1 hit
InterProⁱ	View protein in InterPro IPR023398 TIF_eIF4e-like IPR001040 TIF_eIF_4E IPR019770 TIF_eIF_4E_CS
PANTHERⁱ	PTHR11960 PTHR11960, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01652 IF4E, 1 hit
SUPFAMⁱ	SSF55418 SSF55418, 1 hit
PROSITEⁱ	View protein in PROSITE PS00813 IF4E, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P06730-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATVEPETTP TPNPPTTEEE KTESNQEVAN PEHYIKHPLQ NRWALWFFKN 
        60         70         80         90        100
DKSKTWQANL RLISKFDTVE DFWALYNHIQ LSSNLMPGCD YSLFKDGIEP 
       110        120        130        140        150
MWEDEKNKRG GRWLITLNKQ QRRSDLDRFW LETLLCLIGE SFDDYSDDVC 
       160        170        180        190        200
GAVVNVRAKG DKIAIWTTEC ENREAVTHIG RVYKERLGLP PKIVIGYQSH 
       210 
ADTATKSGST TKNRFVV

Length:217

Mass (Da):25,097

Last modified:February 1, 1996 - v2

Checksum:ⁱB869B8DE615E699D

GO

Isoform 2 (identifier: P06730-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
133-133: T → TRWDLAMLPRLVSNFWPQVILPLQPPKVLELQ

« Hide

        10         20         30         40         50
MATVEPETTP TPNPPTTEEE KTESNQEVAN PEHYIKHPLQ NRWALWFFKN 
        60         70         80         90        100
DKSKTWQANL RLISKFDTVE DFWALYNHIQ LSSNLMPGCD YSLFKDGIEP 
       110        120        130        140        150
MWEDEKNKRG GRWLITLNKQ QRRSDLDRFW LETRWDLAML PRLVSNFWPQ 
       160        170        180        190        200
VILPLQPPKV LELQLLCLIG ESFDDYSDDV CGAVVNVRAK GDKIAIWTTE 
       210        220        230        240 
CENREAVTHI GRVYKERLGL PPKIVIGYQS HADTATKSGS TTKNRFVV

Note: No experimental confirmation available.

Show »

Length:248

Mass (Da):28,778

Checksum:ⁱ3869E3249A241190

GO

Isoform 3 (identifier: P06730-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-6: MATVEP → MLDLTSRGQVGTSRRMAEAACSAHFL

« Hide

        10         20         30         40         50
MLDLTSRGQV GTSRRMAEAA CSAHFLETTP TPNPPTTEEE KTESNQEVAN 
        60         70         80         90        100
PEHYIKHPLQ NRWALWFFKN DKSKTWQANL RLISKFDTVE DFWALYNHIQ 
       110        120        130        140        150
LSSNLMPGCD YSLFKDGIEP MWEDEKNKRG GRWLITLNKQ QRRSDLDRFW 
       160        170        180        190        200
LETLLCLIGE SFDDYSDDVC GAVVNVRAKG DKIAIWTTEC ENREAVTHIG 
       210        220        230 
RVYKERLGLP PKIVIGYQSH ADTATKSGST TKNRFVV

Note: No experimental confirmation available.

Show »

Length:237

Mass (Da):27,260

Checksum:ⁱD4925235C678DE08

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6RBW1	D6RBW1_HUMAN	Eukaryotic translation initiation f... Eukaryotic translation initiation factor 4E	EIF4E	245	Annotation score:
H0Y8J7	H0Y8J7_HUMAN	Eukaryotic translation initiation f... Eukaryotic translation initiation factor 4E	EIF4E	155	Annotation score:
D6RFJ3	D6RFJ3_HUMAN	Eukaryotic translation initiation f... Eukaryotic translation initiation factor 4E	EIF4E	42	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	127	D → N in AAH12611 (PubMed:15489334).Curated		1

Mass spectrometryⁱ

Molecular mass is 24964.3 Da from positions 2 - 217. Determined by ESI. 1 Publication

Molecular mass is 24960 Da from positions 2 - 217. Determined by ESI. 1 Publication

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_043591	1 – 6	MATVEP → MLDLTSRGQVGTSRRMAEAA CSAHFL in isoform 3. 1 Publication		6
Alternative sequenceⁱVSP_042014	133	T → TRWDLAMLPRLVSNFWPQVI LPLQPPKVLELQ in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M15353 mRNA Translation: AAC13647.1 AK300982 mRNA Translation: BAH13387.1 AC019131 Genomic DNA No translation available. AC093836 Genomic DNA No translation available. BC012611 mRNA Translation: AAH12611.1 BC035166 mRNA Translation: AAH35166.1 BC043226 mRNA Translation: AAH43226.1 BM849222 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34031.1 [P06730-1] CCDS47109.1 [P06730-3] CCDS54779.1 [P06730-2]
PIRⁱ	A26411
NCBI Reference Sequences More...RefSeqⁱ	NP_001124150.1, NM_001130678.2 [P06730-3] NP_001124151.1, NM_001130679.2 [P06730-2] NP_001317946.1, NM_001331017.1 NP_001959.1, NM_001968.4 [P06730-1]
UniGeneⁱ	Hs.13211 Hs.249718

Genome annotation databases

Ensemblⁱ	ENST00000280892; ENSP00000280892; ENSG00000151247 [P06730-3] ENST00000450253; ENSP00000389624; ENSG00000151247 [P06730-1] ENST00000505992; ENSP00000425561; ENSG00000151247 [P06730-2]
GeneIDⁱ	1977
KEGGⁱ	hsa:1977
UCSC genome browser More...UCSCⁱ	uc003hue.3 human [P06730-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Chromosomal rearrangement

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P06730	EIF4E isoform 1		PANTR		217	UniRef100_P06730
Eukaryotic translation initiation factor 4E isoform 1		MACMU		217
Macaca fascicularis brain cDNA clone: QtrA-12942, similar to human eukaryotic translation initiation factor 4E (EIF4E), mRNA, RefSeq: NM_001968.1		MACFA		217
Uncharacterized protein		COLAP		217
EIF4E isoform 1		PONAB		217
+6
P06730-2	Uncharacterized protein		GORGO		245	UniRef100_G3S841
P06730-3	Eukaryotic translation initiation factor 4E isoform A (Fragment)		HUMAN		237	UniRef100_P06730-3

Protein	Similar proteins		Species	Score	Length	Source
P06730	Eukaryotic translation initiation factor 4E		XENLA		213	UniRef90_P06730
EIF4E isoform 1		PANTR		217
Eukaryotic translation initiation factor 4E isoform 1		MACMU		217
Macaca fascicularis brain cDNA clone: QtrA-12942, similar to human eukaryotic translation initiation factor 4E (EIF4E), mRNA, RefSeq: NM_001968.1		MACFA		217
Uncharacterized protein		COLAP		217
+11
P06730-2	Eukaryotic translation initiation factor 4E		SAIBB		248	UniRef90_A0A2K6U2Y5
Uncharacterized protein		Cebus capucinus imitator		248
Uncharacterized protein		CERAT		247
Uncharacterized protein		MANLE		247
Uncharacterized protein		PAPAN		247
+9
P06730-3	Eukaryotic translation initiation factor 4E isoform A (Fragment)		HUMAN		237	UniRef90_P06730-3
Uncharacterized protein		PANPA		240
Eukaryotic translation initiation factor 4E		PANTR		240
Uncharacterized protein		MACMU		240
Testis cDNA, clone: QtsA-14777, similar to human eukaryotic translation initiation factor 4E (EIF4E),mRNA, RefSeq: NM_001968.1		MACFA		240
+25

Protein	Similar proteins		Species	Score	Length	Source
P06730	Eukaryotic translation initiation factor 4E		XENLA		213	UniRef50_P06730
Eukaryotic translation initiation factor 4E-1B		DANRE		214
EIF4E isoform 1		PANTR		217
Eukaryotic translation initiation factor 4E isoform 1		MACMU		217
Macaca fascicularis brain cDNA clone: QtrA-12942, similar to human eukaryotic translation initiation factor 4E (EIF4E), mRNA, RefSeq: NM_001968.1		MACFA		217
+313
P06730-2	Eukaryotic translation initiation factor 4E type 1B		MOUSE		244	UniRef50_Q3UTA9
Eukaryotic translation initiation factor 4E family member 1B		AILME		252
Uncharacterized protein		PIG		245
Eukaryotic translation initiation factor 4ea		NOTKU		216
Uncharacterized protein		ORENI		242
+107
P06730-3	Eukaryotic translation initiation factor 4E	)	MOUSE		217	UniRef50_P06730-3
Eukaryotic translation initiation factor 4E		RAT		217
Eukaryotic translation initiation factor 4E		RABIT		217
Eukaryotic translation initiation factor 4E		BOVIN		217
Eukaryotic translation initiation factor 4E isoform A (Fragment)		HUMAN		237
+231

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M15353 mRNA Translation: AAC13647.1 AK300982 mRNA Translation: BAH13387.1 AC019131 Genomic DNA No translation available. AC093836 Genomic DNA No translation available. BC012611 mRNA Translation: AAH12611.1 BC035166 mRNA Translation: AAH35166.1 BC043226 mRNA Translation: AAH43226.1 BM849222 mRNA No translation available.
CCDSⁱ	CCDS34031.1 [P06730-1] CCDS47109.1 [P06730-3] CCDS54779.1 [P06730-2]
PIRⁱ	A26411
RefSeqⁱ	NP_001124150.1, NM_001130678.2 [P06730-3] NP_001124151.1, NM_001130679.2 [P06730-2] NP_001317946.1, NM_001331017.1 NP_001959.1, NM_001968.4 [P06730-1]
UniGeneⁱ	Hs.13211 Hs.249718

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1IPB	X-ray	2.00	A	1-217	[»]
	1IPC	X-ray	2.00	A	1-217	[»]
	1WKW	X-ray	2.10	A	27-217	[»]
	2GPQ	NMR	-	A	1-217	[»]
	2V8W	X-ray	2.30	A/E	1-217	[»]
	2V8X	X-ray	2.30	A/E	1-217	[»]
	2V8Y	X-ray	2.10	A/E	1-217	[»]
	2W97	X-ray	2.29	A/B	1-217	[»]
	3AM7	X-ray	2.20	A	27-217	[»]
	3TF2	X-ray	2.10	A/B/C/D	1-217	[»]
	3U7X	X-ray	2.10	A/B	1-217	[»]
	4AZA	X-ray	2.16	A/C	1-217	[»]
	4BEA	X-ray	2.57	A	1-217	[»]
	4DT6	X-ray	2.60	A	1-217	[»]
	4DUM	X-ray	2.95	A	1-217	[»]
	4TPW	X-ray	1.50	A/B	28-217	[»]
	4TQB	X-ray	1.59	A/B	28-217	[»]
	4TQC	X-ray	1.80	A/B	28-217	[»]
	4UED	X-ray	1.75	A	36-217	[»]
	5EHC	X-ray	2.40	A	1-217	[»]
	5EI3	X-ray	1.71	A	1-217	[»]
	5EIR	X-ray	2.69	A	1-217	[»]
	5EKV	X-ray	3.61	A/C	1-217	[»]
	5GW6	X-ray	1.97	A	23-217	[»]
	5T46	X-ray	1.53	A/C	1-217	[»]
ProteinModelPortalⁱ	P06730
SMRⁱ	P06730
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108292, 51 interactors
CORUMⁱ	P06730
DIPⁱ	DIP-22N
ELMⁱ	P06730
IntActⁱ	P06730, 45 interactors
MINTⁱ	P06730

Chemistry databases

BindingDBⁱ	P06730
ChEMBLⁱ	CHEMBL4848
DrugBankⁱ	DB01649 7-Methyl-Gpppa DB02716 7-Methyl-Guanosine-5'-Triphosphate DB01960 7n-Methyl-8-Hydroguanosine-5'-Diphosphate DB05165 LY2275796

PTM databases

iPTMnetⁱ	P06730
PhosphoSitePlusⁱ	P06730
SwissPalmⁱ	P06730

Polymorphism and mutation databases

BioMutaⁱ	EIF4E
DMDMⁱ	1352435

2D gel databases

OGPⁱ	P06730
REPRODUCTION-2DPAGEⁱ	IPI00027485

Proteomic databases

EPDⁱ	P06730
MaxQBⁱ	P06730
PeptideAtlasⁱ	P06730
PRIDEⁱ	P06730
ProteomicsDBⁱ	51914 51915 [P06730-2] 51916 [P06730-3]
TopDownProteomicsⁱ	P06730-1 [P06730-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1977
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000280892; ENSP00000280892; ENSG00000151247 [P06730-3] ENST00000450253; ENSP00000389624; ENSG00000151247 [P06730-1] ENST00000505992; ENSP00000425561; ENSG00000151247 [P06730-2]
GeneIDⁱ	1977
KEGGⁱ	hsa:1977
UCSCⁱ	uc003hue.3 human [P06730-1]

Organism-specific databases

CTDⁱ	1977
DisGeNETⁱ	1977
EuPathDBⁱ	HostDB:ENSG00000151247.12
GeneCardsⁱ	EIF4E
H-InvDBⁱ	HIX0039231
HGNCⁱ	HGNC:3287 EIF4E
HPAⁱ	CAB004077 CAB016316 HPA051311
MalaCardsⁱ	EIF4E
MIMⁱ	133440 gene 615091 phenotype
neXtProtⁱ	NX_P06730
OpenTargetsⁱ	ENSG00000151247
Orphanetⁱ	106 Autism
PharmGKBⁱ	PA27714
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00520000055549
HOGENOMⁱ	HOG000186751
HOVERGENⁱ	HBG006130
InParanoidⁱ	P06730
KOⁱ	K03259
OMAⁱ	MKMTIGY
OrthoDBⁱ	EOG091G0IVA
PhylomeDBⁱ	P06730
TreeFamⁱ	TF101526

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1169408 ISG15 antiviral mechanism R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-159227 Transport of the SLBP independent Mature mRNA R-HSA-159230 Transport of the SLBP Dependant Mature mRNA R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript R-HSA-166208 mTORC1-mediated signalling R-HSA-429947 Deadenylation of mRNA R-HSA-72649 Translation initiation complex formation R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72702 Ribosomal scanning and start codon recognition R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
SignaLinkⁱ	P06730
SIGNORⁱ	P06730

Miscellaneous databases

ChiTaRSⁱ	EIF4E human
EvolutionaryTraceⁱ	P06730
GeneWikiⁱ	EIF4E
GenomeRNAiⁱ	1977
Protein Ontology More...PROⁱ	PR:P06730
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000151247 Expressed in 221 organ(s), highest expression level in testis
CleanExⁱ	HS_EIF4E
ExpressionAtlasⁱ	P06730 baseline and differential
Genevisibleⁱ	P06730 HS

Family and domain databases

Gene3Dⁱ	3.30.760.10, 1 hit
InterProⁱ	View protein in InterPro IPR023398 TIF_eIF4e-like IPR001040 TIF_eIF_4E IPR019770 TIF_eIF_4E_CS
PANTHERⁱ	PTHR11960 PTHR11960, 1 hit
Pfamⁱ	View protein in Pfam PF01652 IF4E, 1 hit
SUPFAMⁱ	SSF55418 SSF55418, 1 hit
PROSITEⁱ	View protein in PROSITE PS00813 IF4E, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IF4E_HUMAN
Accessionⁱ	P06730Primary (citable) accession number: P06730 Secondary accession number(s): B7Z6V1, D6RCQ6, Q96E95
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
	Last sequence update:	February 1, 1996
	Last modified:	October 10, 2018
	This is version 207 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
Translation initiation factors
List of translation initiation factor entries
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P06730 (IF4E_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Eukaryotic translation initiation factor 4E

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

<p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Mass spectrometryⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ