CD2

Functionⁱ

CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

GO - Molecular functionⁱ

protein homodimerization activity Source: Ensembl
signaling receptor activity
Source: UniProtKB
Non-traceable author statementⁱ
- 7544493
signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17344209

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process
Source: UniProtKB
Traceable author statementⁱ
- 10575274
- 9270771
cell-cell adhesion
Source: UniProtKB
Non-traceable author statementⁱ
- 7544493
cell surface receptor signaling pathway
Source: UniProtKB
Traceable author statementⁱ
- 10575274
heterotypic cell-cell adhesion
Source: UniProtKB
Inferred from direct assayⁱ
- 15345303
leukocyte migration Source: Reactome
membrane raft polarization
Source: UniProtKB
Traceable author statementⁱ
- 11376005
- 11591762
natural killer cell activation
Source: UniProtKB
Non-traceable author statementⁱ
- 12714509
positive regulation of interferon-gamma secretion
Source: UniProtKB
Inferred from direct assayⁱ
- 19109405
positive regulation of interleukin-8 secretion
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19109405
positive regulation of myeloid dendritic cell activation
Source: UniProtKB
Non-traceable author statementⁱ
- 12714509
positive regulation of tumor necrosis factor production
Source: UniProtKB
Inferred from direct assayⁱ
- 19109405
regulation of T cell differentiation
Source: UniProtKB
Non-traceable author statementⁱ
- 11544295
T cell activation
Source: UniProtKB
Traceable author statementⁱ
- 2471997

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion

Biological process

Cell adhesion

Enzyme and pathway databases

Reactomeⁱ	R-HSA-202733 Cell surface interactions at the vascular wall
SignaLinkⁱ	P06729

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: T-cell surface antigen CD2 Alternative name(s): Erythrocyte receptor LFA-2 LFA-3 receptor Rosette receptor T-cell surface antigen T11/Leu-5 CD_antigen: CD2
Gene namesⁱ	Name:CD2 Synonyms:SRBC
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000116824.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1639 CD2
MIMⁱ	186990 gene
neXtProtⁱ	NX_P06729

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	25 – 209	ExtracellularSequence analysisAdd BLAST	185
Transmembraneⁱ	210 – 235	HelicalSequence analysisAdd BLAST	26
Topological domainⁱ	236 – 351	CytoplasmicSequence analysisAdd BLAST	116

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	67	K → R: Loss of CD58 binding. 1 Publication	1
Mutagenesisⁱ	70	Q → K: Loss of CD58 binding. 1 Publication	1
Mutagenesisⁱ	110	Y → D: Loss of CD58 and CD59 binding. 1 Publication	1
Mutagenesisⁱ	111	D → H: Loss of CD58 and CD59 binding. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	914
Open Targets More...OpenTargetsⁱ	ENSG00000116824
PharmGKBⁱ	PA26198

Chemistry databases

ChEMBLⁱ	CHEMBL2040
Drug and drug target database More...DrugBankⁱ	DB00092 Alefacept

Polymorphism and mutation databases

BioMutaⁱ	CD2
DMDMⁱ	160370002

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	Add BLAST		24
ChainⁱPRO_0000014600	25 – 351	T-cell surface antigen CD2Add BLAST		327

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	89	N-linked (GlcNAc...) asparagineCombined sources1 Publication	1
Disulfide bondⁱ	139 ↔ 203	1 Publication
Glycosylationⁱ	141	N-linked (GlcNAc...) asparagineCombined sources1 Publication	1
Disulfide bondⁱ	146 ↔ 186	1 Publication
Glycosylationⁱ	150	N-linked (GlcNAc...) asparagineCombined sources1 Publication	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P06729
PeptideAtlas More...PeptideAtlasⁱ	P06729
PRIDEⁱ	P06729
ProteomicsDBⁱ	51913

PTM databases

GlyConnectⁱ	586
iPTMnetⁱ	P06729
PhosphoSitePlusⁱ	P06729
UniCarbKBⁱ	P06729

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000116824
CleanExⁱ	HS_CD2
ExpressionAtlasⁱ	P06729 baseline and differential
Genevisibleⁱ	P06729 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002430 HPA003883

HPAⁱ

CAB002430
HPA003883

Interactionⁱ

Subunit structureⁱ

Interacts with CD48 (By similarity). Interacts with CD58 (LFA-3) (PubMed:10380930). Interacts with CD2AP (By similarity). Interacts with PSTPIP1 (PubMed:9857189).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CD2AP	Q9Y5K6	6	EBI-3912464,EBI-298152
CD2BP2	O95400	16	EBI-3912464,EBI-768015
FYN	P06241	3	EBI-3912464,EBI-515315
PSTPIP1	O43586	6	EBI-3912464,EBI-1050964
SH3KBP1	Q96B97	3	EBI-3912464,EBI-346595

Show more details

GO - Molecular functionⁱ

protein homodimerization activity Source: Ensembl
signaling receptor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17344209

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107352, 16 interactors
ELMⁱ	P06729
IntActⁱ	P06729, 10 interactors
Molecular INTeraction database More...MINTⁱ	P06729
STRINGⁱ	9606.ENSP00000358490

Chemistry databases

BindingDBⁱ

P06729

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	31 – 36	Combined sources	6
Beta strandⁱ	41 – 43	Combined sources	3
Beta strandⁱ	52 – 61	Combined sources	10
Helixⁱ	62 – 64	Combined sources	3
Beta strandⁱ	67 – 71	Combined sources	5
Helixⁱ	73 – 75	Combined sources	3
Beta strandⁱ	77 – 80	Combined sources	4
Beta strandⁱ	84 – 86	Combined sources	3
Turnⁱ	88 – 90	Combined sources	3
Beta strandⁱ	92 – 94	Combined sources	3
Helixⁱ	99 – 101	Combined sources	3
Beta strandⁱ	103 – 111	Combined sources	9
Beta strandⁱ	116 – 127	Combined sources	12
Beta strandⁱ	134 – 138	Combined sources	5
Turnⁱ	139 – 142	Combined sources	4
Beta strandⁱ	143 – 147	Combined sources	5
Beta strandⁱ	155 – 162	Combined sources	8
Beta strandⁱ	164 – 170	Combined sources	7
Beta strandⁱ	172 – 175	Combined sources	4
Beta strandⁱ	180 – 189	Combined sources	10
Beta strandⁱ	194 – 203	Combined sources	10

3D structure databases

ProteinModelPortalⁱ	P06729
SMRⁱ	P06729
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P06729

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	25 – 128	Ig-like V-typeAdd BLAST		104
Domainⁱ	129 – 209	Ig-like C2-typeAdd BLAST		81

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	61 – 75	CD58 binding region 11 PublicationAdd BLAST		15
Regionⁱ	106 – 120	CD58 binding region 21 PublicationAdd BLAST		15

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	282 – 338	Pro-richAdd BLAST		57

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IW98 Eukaryota ENOG410Y7BE LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009232
HOGENOMⁱ	HOG000276890
HOVERGENⁱ	HBG000262
InParanoidⁱ	P06729
KEGG Orthology (KO) More...KOⁱ	K06449
OMAⁱ	GTQVHQQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0M7A
PhylomeDBⁱ	P06729
TreeFamⁱ	TF335971

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR015632 CD2 IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR008424 Ig_C2-set IPR013106 Ig_V-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05790 C2-set, 1 hit PF07686 V-set, 1 hit
PRINTSⁱ	PR01870 CD2ANTIGEN
SUPFAMⁱ	SSF48726 SSF48726, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P06729-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSFPCKFVAS FLLIFNVSSK GAVSKEITNA LETWGALGQD INLDIPSFQM 
        60         70         80         90        100
SDDIDDIKWE KTSDKKKIAQ FRKEKETFKE KDTYKLFKNG TLKIKHLKTD 
       110        120        130        140        150
DQDIYKVSIY DTKGKNVLEK IFDLKIQERV SKPKISWTCI NTTLTCEVMN 
       160        170        180        190        200
GTDPELNLYQ DGKHLKLSQR VITHKWTTSL SAKFKCTAGN KVSKESSVEP 
       210        220        230        240        250
VSCPEKGLDI YLIIGICGGG SLLMVFVALL VFYITKRKKQ RSRRNDEELE 
       260        270        280        290        300
TRAHRVATEE RGRKPHQIPA STPQNPATSQ HPPPPPGHRS QAPSHRPPPP 
       310        320        330        340        350
GHRVQHQPQK RPPAPSGTQV HQQKGPPLPR PRVQPKPPHG AAENSLSPSS 

N

Length:351

Mass (Da):39,448

Last modified:October 23, 2007 - v2

Checksum:ⁱA03D853C3B618917

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	287	G → A (PubMed:3490670).Curated		1
Sequence conflictⁱ	339 – 351	HGAAE…SPSSN → MGQQKTHCPLPLIKKDRNCL FQ in AAA51946 (PubMed:3490670).CuratedAdd BLAST		13

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_035504	217	C → Y in a breast cancer sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_017104	266	H → Q3 PublicationsCorresponds to variant dbSNP:rs699738Ensembl.	1
Natural variantⁱVAR_033608	339	H → N. Corresponds to variant dbSNP:rs35880225Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M19806 , M19798, M19800, M19802, M19804 Genomic DNA Translation: AAA53095.1 M16445 mRNA Translation: AAA51738.1 M14362 mRNA Translation: AAA35571.1 M16336 mRNA Translation: AAA51946.1 X07871 , X07872, X07873, X07874 Genomic DNA Translation: CAA30721.1 AL135798 Genomic DNA No translation available. BC033583 mRNA Translation: AAH33583.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS889.1
PIRⁱ	A28967 RWHUC2
NCBI Reference Sequences More...RefSeqⁱ	NP_001315538.1, NM_001328609.1 NP_001758.2, NM_001767.4
UniGeneⁱ	Hs.523500

Genome annotation databases

Ensemblⁱ	ENST00000369478; ENSP00000358490; ENSG00000116824
GeneIDⁱ	914
KEGGⁱ	hsa:914

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P06729	CD2 antigen (P50), sheep red blood cell receptor variant (Fragment)		HUMAN		351
UPI000002B87B		HUMAN		182

Protein	Similar proteins		Species	Score	Length
P06729	CD2 antigen (P50), sheep red blood cell receptor variant (Fragment)		HUMAN		351
T-cell surface antigen CD2		MACFA		351
CD2 isoform 1		PANTR		351
CD2 molecule		PANPA		351
CD2 molecule		MACMU		351
+22

Protein	Similar proteins		Species	Score	Length
P06729	CD2 antigen (P50), sheep red blood cell receptor variant (Fragment)		HUMAN		351
T-cell surface antigen CD2 precursor		MACFA		351
CD2 molecule		CERAT		351
CD2 molecule		MANLE		351
Uncharacterized protein		MACMU		351
+32

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

CD2 entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M19806 , M19798, M19800, M19802, M19804 Genomic DNA Translation: AAA53095.1 M16445 mRNA Translation: AAA51738.1 M14362 mRNA Translation: AAA35571.1 M16336 mRNA Translation: AAA51946.1 X07871 , X07872, X07873, X07874 Genomic DNA Translation: CAA30721.1 AL135798 Genomic DNA No translation available. BC033583 mRNA Translation: AAH33583.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS889.1
PIRⁱ	A28967 RWHUC2
NCBI Reference Sequences More...RefSeqⁱ	NP_001315538.1, NM_001328609.1 NP_001758.2, NM_001767.4
UniGeneⁱ	Hs.523500

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1CDB	NMR	-	A	25-129	[»]
	1GYA	NMR	-	A	25-129	[»]
	1HNF	X-ray	2.50	A	25-206	[»]
	1L2Z	NMR	-	B	294-304	[»]
	1QA9	X-ray	3.20	A/C	28-129	[»]
	2J6O	X-ray	2.22	C	324-333	[»]
	2J7I	X-ray	2.90	C/D	324-333	[»]
ProteinModelPortalⁱ	P06729
SMRⁱ	P06729
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107352, 16 interactors
ELMⁱ	P06729
IntActⁱ	P06729, 10 interactors
Molecular INTeraction database More...MINTⁱ	P06729
STRINGⁱ	9606.ENSP00000358490

Chemistry databases

BindingDBⁱ	P06729
ChEMBLⁱ	CHEMBL2040
Drug and drug target database More...DrugBankⁱ	DB00092 Alefacept

PTM databases

GlyConnectⁱ	586
iPTMnetⁱ	P06729
PhosphoSitePlusⁱ	P06729
UniCarbKBⁱ	P06729

Polymorphism and mutation databases

BioMutaⁱ	CD2
DMDMⁱ	160370002

Proteomic databases

PaxDbⁱ	P06729
PeptideAtlas More...PeptideAtlasⁱ	P06729
PRIDEⁱ	P06729
ProteomicsDBⁱ	51913

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	914
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000369478; ENSP00000358490; ENSG00000116824
GeneIDⁱ	914
KEGGⁱ	hsa:914

Organism-specific databases

CTDⁱ	914
DisGeNET More...DisGeNETⁱ	914
EuPathDBⁱ	HostDB:ENSG00000116824.4
GeneCardsⁱ	CD2
H-InvDBⁱ	HIX0000931
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1639 CD2
Human Protein Atlas More...HPAⁱ	CAB002430 HPA003883
MIMⁱ	186990 gene
neXtProtⁱ	NX_P06729
Open Targets More...OpenTargetsⁱ	ENSG00000116824
PharmGKBⁱ	PA26198
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IW98 Eukaryota ENOG410Y7BE LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000009232
HOGENOMⁱ	HOG000276890
HOVERGENⁱ	HBG000262
InParanoidⁱ	P06729
KEGG Orthology (KO) More...KOⁱ	K06449
OMAⁱ	GTQVHQQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0M7A
PhylomeDBⁱ	P06729
TreeFamⁱ	TF335971

Enzyme and pathway databases

Reactomeⁱ	R-HSA-202733 Cell surface interactions at the vascular wall
SignaLinkⁱ	P06729

Miscellaneous databases

EvolutionaryTraceⁱ	P06729
GeneWikiⁱ	CD2
GenomeRNAiⁱ	914
Protein Ontology More...PROⁱ	PR:P06729
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000116824
CleanExⁱ	HS_CD2
ExpressionAtlasⁱ	P06729 baseline and differential
Genevisibleⁱ	P06729 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR015632 CD2 IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR008424 Ig_C2-set IPR013106 Ig_V-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05790 C2-set, 1 hit PF07686 V-set, 1 hit
PRINTSⁱ	PR01870 CD2ANTIGEN
SUPFAMⁱ	SSF48726 SSF48726, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CD2_HUMAN
Accessionⁱ	P06729Primary (citable) accession number: P06729 Secondary accession number(s): Q96TE5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
	Last sequence update:	October 23, 2007
	Last modified:	July 18, 2018
	This is version 203 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P06729 (CD2_HUMAN)

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T-cell surface antigen CD2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ