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UniProtKB - P06729 (CD2_HUMAN)

Entry version 227 (25 May 2022)
Sequence version 2 (23 Oct 2007)
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Protein

T-cell surface antigen CD2

Gene

CD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P06729

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-202733, Cell surface interactions at the vascular wall

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P06729

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
T-cell surface antigen CD2
Alternative name(s):
Erythrocyte receptor
LFA-2
LFA-3 receptor
Rosette receptor
T-cell surface antigen T11/Leu-5
CD_antigen: CD2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD2
Synonyms:SRBC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1639, CD2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		186990, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P06729

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000116824

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini25 – 209ExtracellularSequence analysisAdd BLAST185
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei210 – 235HelicalSequence analysisAdd BLAST26
Topological domaini236 – 351CytoplasmicSequence analysisAdd BLAST116

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi67K → R: Loss of CD58 binding. 1 Publication1
Mutagenesisi70Q → K: Loss of CD58 binding. 1 Publication1
Mutagenesisi110Y → D: Loss of CD58 and CD59 binding. 1 Publication1
Mutagenesisi111D → H: Loss of CD58 and CD59 binding. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		914

Open Targets

More...OpenTargetsi		ENSG00000116824

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26198

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P06729, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2040

Drug and drug target database

More...DrugBanki		DB00092, Alefacept
DB06371, Siplizumab

DrugCentral

More...DrugCentrali		P06729

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CD2

Domain mapping of disease mutations (DMDM)

More...DMDMi		160370002

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Add BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001460025 – 351T-cell surface antigen CD2Add BLAST327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi89N-linked (GlcNAc...) asparagineCombined sources1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi139 ↔ 2031 Publication
Glycosylationi141N-linked (GlcNAc...) asparagineCombined sources1 Publication1
Disulfide bondi146 ↔ 1861 Publication
Glycosylationi150N-linked (GlcNAc...) asparagineCombined sources1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P06729

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P06729

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P06729

PeptideAtlas

More...PeptideAtlasi		P06729

PRoteomics IDEntifications database

More...PRIDEi		P06729

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51913

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		586, 8 N-Linked glycans

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P06729, 5 sites, 16 N-linked glycans (1 site), 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P06729

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P06729

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in natural killer cells (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000116824, Expressed in granulocyte and 166 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P06729, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P06729, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000116824, Tissue enriched (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CD48 (By similarity).

Interacts with CD58 (LFA-3) (PubMed:10380930).

Interacts with CD2AP (By similarity).

Interacts with PSTPIP1 (PubMed:9857189).

Interacts with FCGR3A; this interaction modulates NK cell activation and cytotoxicity.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107352, 18 interactors

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P06729

Protein interaction database and analysis system

More...IntActi		P06729, 10 interactors

Molecular INTeraction database

More...MINTi		P06729

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000358490

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P06729

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P06729, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1351
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P06729

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P06729

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P06729

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 128Ig-like V-typeAdd BLAST104
Domaini129 – 209Ig-like C2-typeAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni61 – 75CD58 binding region 11 PublicationAdd BLAST15
Regioni106 – 120CD58 binding region 21 PublicationAdd BLAST15
Regioni237 – 351DisorderedSequence analysisAdd BLAST115

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi240 – 266Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi276 – 306Pro residuesSequence analysisAdd BLAST31

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S5UN, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000234540

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_069390_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P06729

Identification of Orthologs from Complete Genome Data

More...OMAi		YCIRRKK

Database of Orthologous Groups

More...OrthoDBi		977841at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P06729

TreeFam database of animal gene trees

More...TreeFami		TF335971

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015632, CD2
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR008424, Ig_C2-set
IPR013106, Ig_V-set

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05790, C2-set, 1 hit
PF07686, V-set, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01870, CD2ANTIGEN

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P06729-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFPCKFVAS FLLIFNVSSK GAVSKEITNA LETWGALGQD INLDIPSFQM 
        60         70         80         90        100
SDDIDDIKWE KTSDKKKIAQ FRKEKETFKE KDTYKLFKNG TLKIKHLKTD 
       110        120        130        140        150
DQDIYKVSIY DTKGKNVLEK IFDLKIQERV SKPKISWTCI NTTLTCEVMN 
       160        170        180        190        200
GTDPELNLYQ DGKHLKLSQR VITHKWTTSL SAKFKCTAGN KVSKESSVEP 
       210        220        230        240        250
VSCPEKGLDI YLIIGICGGG SLLMVFVALL VFYITKRKKQ RSRRNDEELE 
       260        270        280        290        300
TRAHRVATEE RGRKPHQIPA STPQNPATSQ HPPPPPGHRS QAPSHRPPPP 
       310        320        330        340        350
GHRVQHQPQK RPPAPSGTQV HQQKGPPLPR PRVQPKPPHG AAENSLSPSS 

N
Length:351
Mass (Da):39,448
Last modified:October 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA03D853C3B618917
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JVN7Q5JVN7_HUMAN
T-cell surface antigen CD2
CD2
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti287G → A (PubMed:3490670).Curated1
Sequence conflicti339 – 351HGAAE…SPSSN → MGQQKTHCPLPLIKKDRNCL FQ in AAA51946 (PubMed:3490670).CuratedAdd BLAST13

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035504217C → Y in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_017104266H → Q3 PublicationsCorresponds to variant dbSNP:rs699738Ensembl.1
Natural variantiVAR_033608339H → N. Corresponds to variant dbSNP:rs35880225Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M19806 M19804 Genomic DNA Translation: AAA53095.1
M16445 mRNA Translation: AAA51738.1
M14362 mRNA Translation: AAA35571.1
M16336 mRNA Translation: AAA51946.1
X07871 X07874 Genomic DNA Translation: CAA30721.1
AL135798 Genomic DNA No translation available.
BC033583 mRNA Translation: AAH33583.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS889.1

Protein sequence database of the Protein Information Resource

More...PIRi		A28967, RWHUC2

NCBI Reference Sequences

More...RefSeqi		NP_001315538.1, NM_001328609.1
NP_001758.2, NM_001767.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000369478.4; ENSP00000358490.3; ENSG00000116824.5

Database of genes from NCBI RefSeq genomes

More...GeneIDi		914

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:914

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000369478.4; ENSP00000358490.3; NM_001767.5; NP_001758.2

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

CD2 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19806 M19804 Genomic DNA Translation: AAA53095.1
M16445 mRNA Translation: AAA51738.1
M14362 mRNA Translation: AAA35571.1
M16336 mRNA Translation: AAA51946.1
X07871 X07874 Genomic DNA Translation: CAA30721.1
AL135798 Genomic DNA No translation available.
BC033583 mRNA Translation: AAH33583.1
CCDSiCCDS889.1
PIRiA28967, RWHUC2
RefSeqiNP_001315538.1, NM_001328609.1
NP_001758.2, NM_001767.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CDBNMR-A25-129[»]
1GYANMR-A25-129[»]
1HNFX-ray2.50A25-206[»]
1L2ZNMR-B294-304[»]
1QA9X-ray3.20A/C28-129[»]
2J6OX-ray2.22C324-333[»]
2J7IX-ray2.90C/D324-333[»]
AlphaFoldDBiP06729
SMRiP06729
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107352, 18 interactors
ELMiP06729
IntActiP06729, 10 interactors
MINTiP06729
STRINGi9606.ENSP00000358490

Chemistry databases

BindingDBiP06729
ChEMBLiCHEMBL2040
DrugBankiDB00092, Alefacept
DB06371, Siplizumab
DrugCentraliP06729

PTM databases

GlyConnecti586, 8 N-Linked glycans
GlyGeniP06729, 5 sites, 16 N-linked glycans (1 site), 1 O-linked glycan (1 site)
iPTMnetiP06729
PhosphoSitePlusiP06729

Genetic variation databases

BioMutaiCD2
DMDMi160370002

Proteomic databases

jPOSTiP06729
MassIVEiP06729
PaxDbiP06729
PeptideAtlasiP06729
PRIDEiP06729
ProteomicsDBi51913

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P06729, 4 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1086, 2920 antibodies from 52 providers

The DNASU plasmid repository

More...DNASUi		914

Genome annotation databases

EnsembliENST00000369478.4; ENSP00000358490.3; ENSG00000116824.5
GeneIDi914
KEGGihsa:914
MANE-SelectiENST00000369478.4; ENSP00000358490.3; NM_001767.5; NP_001758.2

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		914
DisGeNETi914

GeneCards: human genes, protein and diseases

More...GeneCardsi		CD2
HGNCiHGNC:1639, CD2
HPAiENSG00000116824, Tissue enriched (lymphoid)
MIMi186990, gene
neXtProtiNX_P06729
OpenTargetsiENSG00000116824
PharmGKBiPA26198
VEuPathDBiHostDB:ENSG00000116824

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S5UN, Eukaryota
GeneTreeiENSGT01030000234540
HOGENOMiCLU_069390_0_0_1
InParanoidiP06729
OMAiYCIRRKK
OrthoDBi977841at2759
PhylomeDBiP06729
TreeFamiTF335971

Enzyme and pathway databases

PathwayCommonsiP06729
ReactomeiR-HSA-202733, Cell surface interactions at the vascular wall
SignaLinkiP06729

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		914, 8 hits in 1068 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CD2, human
EvolutionaryTraceiP06729

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CD2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		914
PharosiP06729, Tclin

Protein Ontology

More...PROi		PR:P06729
RNActiP06729, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000116824, Expressed in granulocyte and 166 other tissues
ExpressionAtlasiP06729, baseline and differential
GenevisibleiP06729, HS

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR015632, CD2
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR008424, Ig_C2-set
IPR013106, Ig_V-set
PfamiView protein in Pfam
PF05790, C2-set, 1 hit
PF07686, V-set, 1 hit
PRINTSiPR01870, CD2ANTIGEN
SUPFAMiSSF48726, SSF48726, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06729
Secondary accession number(s): Q96TE5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: October 23, 2007
Last modified: May 25, 2022
This is version 227 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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