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UniProtKB - P06729 (CD2_HUMAN)
Protein
T-cell surface antigen CD2
Gene
CD2
Organism
Homo sapiens (Human)
Status
Functioni
CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
GO - Molecular functioni
- identical protein binding Source: Ensembl
- protein self-association Source: Ensembl
- receptor tyrosine kinase binding Source: Ensembl
- signaling receptor activity Source: UniProtKB
- signaling receptor binding Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB
- cell-cell adhesion Source: GO_Central
- cell surface receptor signaling pathway Source: UniProtKB
- heterotypic cell-cell adhesion Source: UniProtKB
- membrane raft polarization Source: UniProtKB
- natural killer cell activation Source: UniProtKB
- natural killer cell mediated cytotoxicity Source: UniProtKB
- positive regulation of interferon-gamma production Source: UniProtKB
- positive regulation of interleukin-8 production Source: UniProtKB
- positive regulation of myeloid dendritic cell activation Source: UniProtKB
- positive regulation of tumor necrosis factor production Source: UniProtKB
- regulation of T cell differentiation Source: UniProtKB
- T cell activation Source: GO_Central
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
PathwayCommonsi | P06729 |
Reactomei | R-HSA-202733, Cell surface interactions at the vascular wall |
SignaLinki | P06729 |
Names & Taxonomyi
Protein namesi | Recommended name: T-cell surface antigen CD2Alternative name(s): Erythrocyte receptor LFA-2 LFA-3 receptor Rosette receptor T-cell surface antigen T11/Leu-5 CD_antigen: CD2 |
Gene namesi | Name:CD2 Synonyms:SRBC |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1639, CD2 |
MIMi | 186990, gene |
neXtProti | NX_P06729 |
VEuPathDBi | HostDB:ENSG00000116824 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Single-pass type I membrane protein Curated
Extracellular region or secreted
- extracellular region Source: Ensembl
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- anchored component of plasma membrane Source: Ensembl
- cytoplasmic side of plasma membrane Source: Ensembl
- external side of plasma membrane Source: MGI
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- cell surface Source: UniProtKB
- cell-cell junction Source: Ensembl
- membrane raft Source: Ensembl
- protein-containing complex Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 25 – 209 | ExtracellularSequence analysisAdd BLAST | 185 | |
Transmembranei | 210 – 235 | HelicalSequence analysisAdd BLAST | 26 | |
Topological domaini | 236 – 351 | CytoplasmicSequence analysisAdd BLAST | 116 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 67 | K → R: Loss of CD58 binding. 1 Publication | 1 | |
Mutagenesisi | 70 | Q → K: Loss of CD58 binding. 1 Publication | 1 | |
Mutagenesisi | 110 | Y → D: Loss of CD58 and CD59 binding. 1 Publication | 1 | |
Mutagenesisi | 111 | D → H: Loss of CD58 and CD59 binding. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 914 |
OpenTargetsi | ENSG00000116824 |
PharmGKBi | PA26198 |
Miscellaneous databases
Pharosi | P06729, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2040 |
DrugBanki | DB00092, Alefacept DB06371, Siplizumab |
DrugCentrali | P06729 |
Genetic variation databases
BioMutai | CD2 |
DMDMi | 160370002 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Add BLAST | 24 | |
ChainiPRO_0000014600 | 25 – 351 | T-cell surface antigen CD2Add BLAST | 327 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 89 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | |
Disulfide bondi | 139 ↔ 203 | 1 Publication | ||
Glycosylationi | 141 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 | |
Disulfide bondi | 146 ↔ 186 | 1 Publication | ||
Glycosylationi | 150 | N-linked (GlcNAc...) asparagineCombined sources1 Publication | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | P06729 |
MassIVEi | P06729 |
PaxDbi | P06729 |
PeptideAtlasi | P06729 |
PRIDEi | P06729 |
ProteomicsDBi | 51913 |
PTM databases
GlyConnecti | 586, 8 N-Linked glycans |
GlyGeni | P06729, 5 sites, 16 N-linked glycans (1 site), 1 O-linked glycan (1 site) |
iPTMneti | P06729 |
PhosphoSitePlusi | P06729 |
Expressioni
Tissue specificityi
Expressed in natural killer cells (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000116824, Expressed in granulocyte and 166 other tissues |
ExpressionAtlasi | P06729, baseline and differential |
Genevisiblei | P06729, HS |
Organism-specific databases
HPAi | ENSG00000116824, Tissue enriched (lymphoid) |
Interactioni
Subunit structurei
Binary interactionsi
P06729
With | #Exp. | IntAct |
---|---|---|
CD2AP [Q9Y5K6] | 4 | EBI-3912464,EBI-298152 |
CD2BP2 [O95400] | 9 | EBI-3912464,EBI-768015 |
SH3KBP1 [Q96B97] | 3 | EBI-3912464,EBI-346595 |
GO - Molecular functioni
- identical protein binding Source: Ensembl
- protein self-association Source: Ensembl
- receptor tyrosine kinase binding Source: Ensembl
- signaling receptor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107352, 18 interactors |
ELMi | P06729 |
IntActi | P06729, 10 interactors |
MINTi | P06729 |
STRINGi | 9606.ENSP00000358490 |
Chemistry databases
BindingDBi | P06729 |
Miscellaneous databases
RNActi | P06729, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P06729 |
SMRi | P06729 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P06729 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 25 – 128 | Ig-like V-typeAdd BLAST | 104 | |
Domaini | 129 – 209 | Ig-like C2-typeAdd BLAST | 81 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 61 – 75 | CD58 binding region 11 PublicationAdd BLAST | 15 | |
Regioni | 106 – 120 | CD58 binding region 21 PublicationAdd BLAST | 15 | |
Regioni | 237 – 351 | DisorderedSequence analysisAdd BLAST | 115 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 240 – 266 | Basic and acidic residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 276 – 306 | Pro residuesSequence analysisAdd BLAST | 31 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S5UN, Eukaryota |
GeneTreei | ENSGT01030000234540 |
HOGENOMi | CLU_069390_0_0_1 |
InParanoidi | P06729 |
OMAi | YCIRRKK |
OrthoDBi | 977841at2759 |
PhylomeDBi | P06729 |
TreeFami | TF335971 |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR015632, CD2 IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR008424, Ig_C2-set IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF05790, C2-set, 1 hit PF07686, V-set, 1 hit |
PRINTSi | PR01870, CD2ANTIGEN |
SUPFAMi | SSF48726, SSF48726, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P06729-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFPCKFVAS FLLIFNVSSK GAVSKEITNA LETWGALGQD INLDIPSFQM
60 70 80 90 100
SDDIDDIKWE KTSDKKKIAQ FRKEKETFKE KDTYKLFKNG TLKIKHLKTD
110 120 130 140 150
DQDIYKVSIY DTKGKNVLEK IFDLKIQERV SKPKISWTCI NTTLTCEVMN
160 170 180 190 200
GTDPELNLYQ DGKHLKLSQR VITHKWTTSL SAKFKCTAGN KVSKESSVEP
210 220 230 240 250
VSCPEKGLDI YLIIGICGGG SLLMVFVALL VFYITKRKKQ RSRRNDEELE
260 270 280 290 300
TRAHRVATEE RGRKPHQIPA STPQNPATSQ HPPPPPGHRS QAPSHRPPPP
310 320 330 340 350
GHRVQHQPQK RPPAPSGTQV HQQKGPPLPR PRVQPKPPHG AAENSLSPSS
N
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ5JVN7 | Q5JVN7_HUMAN | T-cell surface antigen CD2 | CD2 | 133 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 287 | G → A (PubMed:3490670).Curated | 1 | |
Sequence conflicti | 339 – 351 | HGAAE…SPSSN → MGQQKTHCPLPLIKKDRNCL FQ in AAA51946 (PubMed:3490670).CuratedAdd BLAST | 13 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035504 | 217 | C → Y in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_017104 | 266 | H → Q3 PublicationsCorresponds to variant dbSNP:rs699738Ensembl. | 1 | |
Natural variantiVAR_033608 | 339 | H → N. Corresponds to variant dbSNP:rs35880225Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M19806 , M19798, M19800, M19802, M19804 Genomic DNA Translation: AAA53095.1 M16445 mRNA Translation: AAA51738.1 M14362 mRNA Translation: AAA35571.1 M16336 mRNA Translation: AAA51946.1 X07871 , X07872, X07873, X07874 Genomic DNA Translation: CAA30721.1 AL135798 Genomic DNA No translation available. BC033583 mRNA Translation: AAH33583.1 |
CCDSi | CCDS889.1 |
PIRi | A28967, RWHUC2 |
RefSeqi | NP_001315538.1, NM_001328609.1 NP_001758.2, NM_001767.4 |
Genome annotation databases
Ensembli | ENST00000369478.4; ENSP00000358490.3; ENSG00000116824.5 |
GeneIDi | 914 |
KEGGi | hsa:914 |
MANE-Selecti | ENST00000369478.4; ENSP00000358490.3; NM_001767.5; NP_001758.2 |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia CD2 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M19806 , M19798, M19800, M19802, M19804 Genomic DNA Translation: AAA53095.1 M16445 mRNA Translation: AAA51738.1 M14362 mRNA Translation: AAA35571.1 M16336 mRNA Translation: AAA51946.1 X07871 , X07872, X07873, X07874 Genomic DNA Translation: CAA30721.1 AL135798 Genomic DNA No translation available. BC033583 mRNA Translation: AAH33583.1 |
CCDSi | CCDS889.1 |
PIRi | A28967, RWHUC2 |
RefSeqi | NP_001315538.1, NM_001328609.1 NP_001758.2, NM_001767.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1CDB | NMR | - | A | 25-129 | [»] | |
1GYA | NMR | - | A | 25-129 | [»] | |
1HNF | X-ray | 2.50 | A | 25-206 | [»] | |
1L2Z | NMR | - | B | 294-304 | [»] | |
1QA9 | X-ray | 3.20 | A/C | 28-129 | [»] | |
2J6O | X-ray | 2.22 | C | 324-333 | [»] | |
2J7I | X-ray | 2.90 | C/D | 324-333 | [»] | |
AlphaFoldDBi | P06729 | |||||
SMRi | P06729 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107352, 18 interactors |
ELMi | P06729 |
IntActi | P06729, 10 interactors |
MINTi | P06729 |
STRINGi | 9606.ENSP00000358490 |
Chemistry databases
BindingDBi | P06729 |
ChEMBLi | CHEMBL2040 |
DrugBanki | DB00092, Alefacept DB06371, Siplizumab |
DrugCentrali | P06729 |
PTM databases
GlyConnecti | 586, 8 N-Linked glycans |
GlyGeni | P06729, 5 sites, 16 N-linked glycans (1 site), 1 O-linked glycan (1 site) |
iPTMneti | P06729 |
PhosphoSitePlusi | P06729 |
Genetic variation databases
BioMutai | CD2 |
DMDMi | 160370002 |
Proteomic databases
jPOSTi | P06729 |
MassIVEi | P06729 |
PaxDbi | P06729 |
PeptideAtlasi | P06729 |
PRIDEi | P06729 |
ProteomicsDBi | 51913 |
Protocols and materials databases
ABCDi | P06729, 4 sequenced antibodies |
Antibodypediai | 1086, 2920 antibodies from 52 providers |
DNASUi | 914 |
Genome annotation databases
Ensembli | ENST00000369478.4; ENSP00000358490.3; ENSG00000116824.5 |
GeneIDi | 914 |
KEGGi | hsa:914 |
MANE-Selecti | ENST00000369478.4; ENSP00000358490.3; NM_001767.5; NP_001758.2 |
Organism-specific databases
CTDi | 914 |
DisGeNETi | 914 |
GeneCardsi | CD2 |
HGNCi | HGNC:1639, CD2 |
HPAi | ENSG00000116824, Tissue enriched (lymphoid) |
MIMi | 186990, gene |
neXtProti | NX_P06729 |
OpenTargetsi | ENSG00000116824 |
PharmGKBi | PA26198 |
VEuPathDBi | HostDB:ENSG00000116824 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S5UN, Eukaryota |
GeneTreei | ENSGT01030000234540 |
HOGENOMi | CLU_069390_0_0_1 |
InParanoidi | P06729 |
OMAi | YCIRRKK |
OrthoDBi | 977841at2759 |
PhylomeDBi | P06729 |
TreeFami | TF335971 |
Enzyme and pathway databases
PathwayCommonsi | P06729 |
Reactomei | R-HSA-202733, Cell surface interactions at the vascular wall |
SignaLinki | P06729 |
Miscellaneous databases
BioGRID-ORCSi | 914, 8 hits in 1068 CRISPR screens |
ChiTaRSi | CD2, human |
EvolutionaryTracei | P06729 |
GeneWikii | CD2 |
GenomeRNAii | 914 |
Pharosi | P06729, Tclin |
PROi | PR:P06729 |
RNActi | P06729, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000116824, Expressed in granulocyte and 166 other tissues |
ExpressionAtlasi | P06729, baseline and differential |
Genevisiblei | P06729, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR015632, CD2 IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR008424, Ig_C2-set IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF05790, C2-set, 1 hit PF07686, V-set, 1 hit |
PRINTSi | PR01870, CD2ANTIGEN |
SUPFAMi | SSF48726, SSF48726, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CD2_HUMAN | |
Accessioni | P06729Primary (citable) accession number: P06729 Secondary accession number(s): Q96TE5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | October 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 227 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references