T-cell surface antigen CD2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• identical protein binding Source: Ensembl
• protein self-association Source: Ensembl
• receptor tyrosine kinase binding Source: Ensembl
• signaling receptor activity Source: UniProtKB <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • Ref.14

    "Conformation and function of the N-linked glycan in the adhesion domain of human CD2."
    Wyss D.F., Choi J.S., Li J., Knoppers M.H., Willis K.J., Arulanandam A.R., Smolyar A., Reinherz E.L., Wagner G.
    Science 269:1273-1278(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: STRUCTURE BY NMR OF 25-129, GLYCOSYLATION AT ASN-89.
• signaling receptor binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "The contribution of conformational adjustments and long-range electrostatic forces to the CD2/CD58 interaction."
    Kearney A., Avramovic A., Castro M.A., Carmo A.M., Davis S.J., van der Merwe P.A.
    J. Biol. Chem. 282:13160-13166(2007) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• apoptotic process Source: UniProtKB <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • "MHC class I cross-talk with CD2 and CD28 induces specific intracellular signalling and leads to growth retardation and apoptosis via a p56(lck)-dependent mechanism."
    Ruhwald M., Pedersen A.E., Claesson M.H.
    Exp. Clin. Immunogenet. 16:199-211(1999) [PubMed] [Europe PMC] [Abstract]
  • "CD2 induced apoptosis of peripheral T cells."
    Rouleau M., Mollereau B., Bernard A., Metivier D., Rosenthal-Allieri M.A., Charpentier B., Senik A.
    Transplant. Proc. 29:2377-2378(1997) [PubMed] [Europe PMC] [Abstract]
• cell-cell adhesion Source: UniProtKBNon-traceable author statementⁱ
  • Ref.14

    "Conformation and function of the N-linked glycan in the adhesion domain of human CD2."
    Wyss D.F., Choi J.S., Li J., Knoppers M.H., Willis K.J., Arulanandam A.R., Smolyar A., Reinherz E.L., Wagner G.
    Science 269:1273-1278(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: STRUCTURE BY NMR OF 25-129, GLYCOSYLATION AT ASN-89.
• cell surface receptor signaling pathway Source: UniProtKBTraceable author statementⁱ
  • "MHC class I cross-talk with CD2 and CD28 induces specific intracellular signalling and leads to growth retardation and apoptosis via a p56(lck)-dependent mechanism."
    Ruhwald M., Pedersen A.E., Claesson M.H.
    Exp. Clin. Immunogenet. 16:199-211(1999) [PubMed] [Europe PMC] [Abstract]
• heterotypic cell-cell adhesion Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "A novel, rapid and sensitive heterotypic cell adhesion assay for CD2-CD58 interaction, and its application for testing inhibitory peptides."
    Liu J., Chow V.T., Jois S.D.
    J. Immunol. Methods 291:39-49(2004) [PubMed] [Europe PMC] [Abstract]
• leukocyte migration Source: Reactome
• membrane raft polarization Source: UniProtKBTraceable author statementⁱ
  • "Dynamic recruitment of human CD2 into lipid rafts. Linkage to T cell signal transduction."
    Yang H., Reinherz E.L.
    J. Biol. Chem. 276:18775-18785(2001) [PubMed] [Europe PMC] [Abstract]
  • "Endothelial cell costimulation of T cell activation through CD58-CD2 interactions involves lipid raft aggregation."
    Mestas J., Hughes C.C.
    J. Immunol. 167:4378-4385(2001) [PubMed] [Europe PMC] [Abstract]
• natural killer cell activation Source: UniProtKBNon-traceable author statementⁱ
  • "CD2 engagement induces dendritic cell activation: implications for immune surveillance and T-cell activation."
    Crawford K., Stark A., Kitchens B., Sternheim K., Pantazopoulos V., Triantafellow E., Wang Z., Vasir B., Larsen C.E., Gabuzda D., Reinherz E., Alper C.A.
    Blood 102:1745-1752(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interferon-gamma secretion Source: UniProtKBInferred from direct assayⁱ
  • "Human intestinal intraepithelial lymphocytes and epithelial cells coinduce interleukin-8 production through the CD2-CD58 interaction."
    Ebert E.C., Panja A., Praveen R.
    Am. J. Physiol. Gastrointest. Liver Physiol. 296:G671-7(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of interleukin-8 secretion Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Human intestinal intraepithelial lymphocytes and epithelial cells coinduce interleukin-8 production through the CD2-CD58 interaction."
    Ebert E.C., Panja A., Praveen R.
    Am. J. Physiol. Gastrointest. Liver Physiol. 296:G671-7(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of myeloid dendritic cell activation Source: UniProtKBNon-traceable author statementⁱ
  • "CD2 engagement induces dendritic cell activation: implications for immune surveillance and T-cell activation."
    Crawford K., Stark A., Kitchens B., Sternheim K., Pantazopoulos V., Triantafellow E., Wang Z., Vasir B., Larsen C.E., Gabuzda D., Reinherz E., Alper C.A.
    Blood 102:1745-1752(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of tumor necrosis factor production Source: UniProtKBInferred from direct assayⁱ
  • "Human intestinal intraepithelial lymphocytes and epithelial cells coinduce interleukin-8 production through the CD2-CD58 interaction."
    Ebert E.C., Panja A., Praveen R.
    Am. J. Physiol. Gastrointest. Liver Physiol. 296:G671-7(2009) [PubMed] [Europe PMC] [Abstract]
• regulation of T cell differentiation Source: UniProtKBNon-traceable author statementⁱ
  • "Differentiation of regulatory T cells 1 is induced by CD2 costimulation."
    Wakkach A., Cottrez F., Groux H.
    J. Immunol. 167:3107-3113(2001) [PubMed] [Europe PMC] [Abstract]
• T cell activation Source: UniProtKBTraceable author statementⁱ
  • "Structure and function of the erythrocyte receptor CD2 on human T lymphocytes: a review."
    Sayre P.H., Reinherz E.L.
    Scand. J. Rheumatol. Suppl. 76:131-144(1988) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• identical protein binding Source: Ensembl
• protein self-association Source: Ensembl
• receptor tyrosine kinase binding Source: Ensembl
• signaling receptor binding Source: UniProtKBInferred from physical interactionⁱ
  • "The contribution of conformational adjustments and long-range electrostatic forces to the CD2/CD58 interaction."
    Kearney A., Avramovic A., Castro M.A., Carmo A.M., Davis S.J., van der Merwe P.A.
    J. Biol. Chem. 282:13160-13166(2007) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MSFPCKFVAS FLLIFNVSSK GAVSKEITNA LETWGALGQD INLDIPSFQM 
        60         70         80         90        100
SDDIDDIKWE KTSDKKKIAQ FRKEKETFKE KDTYKLFKNG TLKIKHLKTD 
       110        120        130        140        150
DQDIYKVSIY DTKGKNVLEK IFDLKIQERV SKPKISWTCI NTTLTCEVMN 
       160        170        180        190        200
GTDPELNLYQ DGKHLKLSQR VITHKWTTSL SAKFKCTAGN KVSKESSVEP 
       210        220        230        240        250
VSCPEKGLDI YLIIGICGGG SLLMVFVALL VFYITKRKKQ RSRRNDEELE 
       260        270        280        290        300
TRAHRVATEE RGRKPHQIPA STPQNPATSQ HPPPPPGHRS QAPSHRPPPP 
       310        320        330        340        350
GHRVQHQPQK RPPAPSGTQV HQQKGPPLPR PRVQPKPPHG AAENSLSPSS 

N                                                      

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 1
   Human chromosome 1: entries, gene names and cross-references to MIM
2. Human cell differentiation molecules
   CD nomenclature of surface proteins of human leucocytes and list of entries
3. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
4. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
5. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
6. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references