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Protein

Apolipoprotein A-IV

Gene

Apoa4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-8963888 Chylomicron assembly
R-MMU-8963901 Chylomicron remodeling
R-MMU-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein A-IV
Short name:
Apo-AIV
Short name:
ApoA-IV
Alternative name(s):
Apolipoprotein A4
Gene namesi
Name:Apoa4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:88051 Apoa4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chylomicron, HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000000197721 – 395Apolipoprotein A-IVAdd BLAST375

Proteomic databases

MaxQBiP06728
PaxDbiP06728
PeptideAtlasiP06728
PRIDEiP06728

PTM databases

iPTMnetiP06728
PhosphoSitePlusiP06728

Expressioni

Tissue specificityi

Secreted in plasma.

Gene expression databases

BgeeiENSMUSG00000032080 Expressed in 72 organ(s), highest expression level in intestine
CleanExiMM_APOA4
GenevisibleiP06728 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP06728, 3 interactors
MINTiP06728
STRINGi10090.ENSMUSP00000034585

Structurei

3D structure databases

ProteinModelPortaliP06728
SMRiP06728
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati33 – 541Add BLAST22
Repeati60 – 812Add BLAST22
Repeati82 – 1033Add BLAST22
Repeati115 – 1364Add BLAST22
Repeati137 – 1585Add BLAST22
Repeati159 – 1806Add BLAST22
Repeati181 – 2027Add BLAST22
Repeati203 – 2248Add BLAST22
Repeati225 – 2469Add BLAST22
Repeati247 – 26810Add BLAST22
Repeati269 – 28611Add BLAST18
Repeati287 – 30812Add BLAST22
Repeati309 – 33013Add BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni33 – 33013 X 22 AA approximate tandem repeatsAdd BLAST298

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi366 – 389Gln/Glu-richAdd BLAST24

Domaini

Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.

Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IKU1 Eukaryota
ENOG41119VI LUCA
GeneTreeiENSGT00530000063081
HOGENOMiHOG000037942
HOVERGENiHBG105707
InParanoidiP06728
KOiK08760
OMAiATVVWDY
OrthoDBiEOG091G0IA5
TreeFamiTF334458

Family and domain databases

InterProiView protein in InterPro
IPR000074 ApoA_E
PfamiView protein in Pfam
PF01442 Apolipoprotein, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06728-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFLKAAVLTL ALVAITGTRA EVTSDQVANV VWDYFTQLSN NAKEAVEQFQ
60 70 80 90 100
KTDVTQQLST LFQDKLGDAS TYADGVHNKL VPFVVQLSGH LAQETERVKE
110 120 130 140 150
EIKKELEDLR DRMMPHANKV TQTFGENMQK LQEHLKPYAV DLQDQINTQT
160 170 180 190 200
QEMKLQLTPY IQRMQTTIKE NVDNLHTSMM PLATNLKDKF NRNMEELKGH
210 220 230 240 250
LTPRANELKA TIDQNLEDLR RSLAPLTVGV QEKLNHQMEG LAFQMKKNAE
260 270 280 290 300
ELQTKVSAKI DQLQKNLAPL VEDVQSKVKG NTEGLQKSLE DLNRQLEQQV
310 320 330 340 350
EEFRRTVEPM GEMFNKALVQ QLEQFRQQLG PNSGEVESHL SFLEKSLREK
360 370 380 390
VNSFMSTLEK KGSPDQPQAL PLPEQAQEQA QEQAQEQVQP KPLES
Length:395
Mass (Da):45,029
Last modified:July 27, 2011 - v3
Checksum:iC48BE32EED441F71
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15Missing in AAA37253 (PubMed:3796595).Curated1
Sequence conflicti63Q → K in AAA37253 (PubMed:3796595).Curated1
Sequence conflicti93Q → K in AAA37253 (PubMed:3796595).Curated1
Sequence conflicti93Q → K in AAA37214 (PubMed:1648102).Curated1
Sequence conflicti93Q → K in AAA37215 (PubMed:1648102).Curated1
Sequence conflicti207E → R in AAA37253 (PubMed:3796595).Curated1
Sequence conflicti288S → A in AAA37253 (PubMed:3796595).Curated1
Sequence conflicti294 – 295RQ → KA in AAA37253 (PubMed:3796595).Curated2
Sequence conflicti315 – 316NK → GG in AAA37253 (PubMed:3796595).Curated2

Polymorphismi

There is a polymorphism within a series of imperfect repeats encoding the sequence E-Q-[AV]-Q. Insertions or deletions of 12 nucleotides have given rise to three forms characterized by three (129), four (C57BL/6), or five (M.castaneus) copies of the repeat unit.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti382 – 385Missing in strain: various strains. 4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13966 Genomic DNA Translation: AAA37253.1
M64248 mRNA Translation: AAA37214.1
M64249 mRNA Translation: AAA37215.1
AK161535 mRNA Translation: BAE36447.1
AK168687 mRNA Translation: BAE40533.1
CH466522 Genomic DNA Translation: EDL25684.1
BC010769 mRNA Translation: AAH10769.1
CCDSiCCDS23142.1
PIRiA25281
A40892
B40892
RefSeqiNP_031494.2, NM_007468.2
UniGeneiMm.4533

Genome annotation databases

EnsembliENSMUST00000034585; ENSMUSP00000034585; ENSMUSG00000032080
GeneIDi11808
KEGGimmu:11808
UCSCiuc009phd.1 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13966 Genomic DNA Translation: AAA37253.1
M64248 mRNA Translation: AAA37214.1
M64249 mRNA Translation: AAA37215.1
AK161535 mRNA Translation: BAE36447.1
AK168687 mRNA Translation: BAE40533.1
CH466522 Genomic DNA Translation: EDL25684.1
BC010769 mRNA Translation: AAH10769.1
CCDSiCCDS23142.1
PIRiA25281
A40892
B40892
RefSeqiNP_031494.2, NM_007468.2
UniGeneiMm.4533

3D structure databases

ProteinModelPortaliP06728
SMRiP06728
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP06728, 3 interactors
MINTiP06728
STRINGi10090.ENSMUSP00000034585

PTM databases

iPTMnetiP06728
PhosphoSitePlusiP06728

Proteomic databases

MaxQBiP06728
PaxDbiP06728
PeptideAtlasiP06728
PRIDEiP06728

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034585; ENSMUSP00000034585; ENSMUSG00000032080
GeneIDi11808
KEGGimmu:11808
UCSCiuc009phd.1 mouse

Organism-specific databases

CTDi337
MGIiMGI:88051 Apoa4

Phylogenomic databases

eggNOGiENOG410IKU1 Eukaryota
ENOG41119VI LUCA
GeneTreeiENSGT00530000063081
HOGENOMiHOG000037942
HOVERGENiHBG105707
InParanoidiP06728
KOiK08760
OMAiATVVWDY
OrthoDBiEOG091G0IA5
TreeFamiTF334458

Enzyme and pathway databases

ReactomeiR-MMU-8963888 Chylomicron assembly
R-MMU-8963901 Chylomicron remodeling
R-MMU-975634 Retinoid metabolism and transport

Miscellaneous databases

ChiTaRSiApoa4 mouse
PROiPR:P06728
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032080 Expressed in 72 organ(s), highest expression level in intestine
CleanExiMM_APOA4
GenevisibleiP06728 MM

Family and domain databases

InterProiView protein in InterPro
IPR000074 ApoA_E
PfamiView protein in Pfam
PF01442 Apolipoprotein, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiAPOA4_MOUSE
AccessioniPrimary (citable) accession number: P06728
Secondary accession number(s): Q91XF8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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