UniProtKB - P06721 (METC_ECOLI)

BLAST

>sp|P06721|METC_ECOLI Cystathionine beta-lyase MetC OS=Escherichia coli (strain K12) OX=83333 GN=metC PE=1 SV=1
MADKKLDTQLVNAGRSKKYTLGAVNSVIQRASSLVFDSVEAKKHATRNRANGELFYGRRG
TLTHFSLQQAMCELEGGAGCVLFPCGAAAVANSILAFIEQGDHVLMTNTAYEPSQDFCSK
ILSKLGVTTSWFDPLIGADIVKHLQPNTKIVFLESPGSITMEVHDVPAIVAAVRSVVPDA
IIMIDNTWAAGVLFKALDFGIDVSIQAATKYLVGHSDAMIGTAVCNARCWEQLRENAYLM
GQMVDADTAYITSRGLRTLGVRLRQHHESSLKVAEWLAEHPQVARVNHPALPGSKGHEFW
KRDFTGSSGLFSFVLKKKLNNEELANYLDNFSLFSMAYSWGGYESLILANQPEHIAAIRP
QGEIDFSGTLIRLHIGLEDVDDLIADLDAGFARIV

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History
Entry version 161 (07 Nov 2018)
Sequence version 1 (01 Jan 1988)
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Protein

Cystathionine beta-lyase MetC

Gene

metC

Organism

Escherichia coli (strain K12)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Primarily catalyzes the cleavage of cystathionine to homocysteine, pyruvate and ammonia during methionine biosynthesis (PubMed:7049234). Also exhibits cysteine desulfhydrase activity, producing sulfide from cysteine (PubMed:12883870). In addition, under certain growth conditions, exhibits significant alanine racemase coactivity (PubMed:21193606).3 Publications

Catalytic activityⁱ

L-cystathionine + H₂O = L-homocysteine + NH₃ + pyruvate.1 Publication

L-cysteine + H₂O = sulfide + NH₃ + pyruvate.1 Publication

An L-cysteine-S-conjugate + H₂O = RSH + NH₃ + pyruvate.1 Publication

Cofactorⁱ

pyridoxal 5'-phosphate3 Publications

Activity regulationⁱ

L-cysteine inhibits cystathionine beta-lyase activity competitively (PubMed:7049234). Inhibited by aminoethoxyvinylglycine (AVG) (PubMed:9376370).2 Publications

Kineticsⁱ

V_max=
249 µmol/min/mg enzyme with L-cystathionine as substrate
1 Publication
Manual assertion based on experiment inⁱ
- Ref.5
  "Cloning, purification, and characterization of beta-cystathionase from Escherichia coli."
  Dwivedi C.M., Ragin R.C., Uren J.R.
  Biochemistry 21:3064-3069(1982) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, COFACTOR, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES.
V_max=
263 µmol/min/mg enzyme with L-cystine as substrate
1 Publication
Manual assertion based on experiment inⁱ
- Ref.5
  "Cloning, purification, and characterization of beta-cystathionase from Escherichia coli."
  Dwivedi C.M., Ragin R.C., Uren J.R.
  Biochemistry 21:3064-3069(1982) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, COFACTOR, ACTIVITY REGULATION, BIOPHYSICOCHEMICAL PROPERTIES.

pH dependenceⁱ

Optimum pH is 8.0-9.0.1 Publication

Pathwayⁱ: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from L-cystathionine.Curated
Proteins known to be involved in this subpathway in this organism are:

Cystathionine beta-lyase MetC (metC)

This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from L-cystathionine, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

GO - Molecular functionⁱ

cystathionine beta-lyase activity
Source: EcoCyc
Inferred from direct assayⁱ
- 3513164
L-cysteine desulfhydrase activity
Source: EcoCyc
Inferred from mutant phenotypeⁱ
- 12883870
pyridoxal phosphate binding
Source: EcoCyc
Inferred from direct assayⁱ
- 8831789

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

methionine biosynthetic process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Lyase
Biological process	Amino-acid biosynthesis, Methionine biosynthesis
Ligand	Pyridoxal phosphate

Enzyme and pathway databases

BioCycⁱ	EcoCyc:CYSTATHIONINE-BETA-LYASE-MONOMER MetaCyc:CYSTATHIONINE-BETA-LYASE-MONOMER
BRENDAⁱ	4.4.1.8 2026
UniPathwayⁱ	UPA00051;UER00078

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cystathionine beta-lyase MetC1 Publication (EC:4.4.1.131 Publication) Short name: CBL1 Publication Short name: CL1 Publication Alternative name(s): Beta-cystathionase MetC1 Publication Cysteine desulfhydrase MetC1 Publication (EC:4.4.1.281 Publication) Short name: CD1 Publication Cysteine lyase MetC Cysteine-S-conjugate beta-lyase MetC
Gene namesⁱ	Name:metC1 Publication Ordered Locus Names:b3008, JW2975
Organismⁱ	Escherichia coli (strain K12)
Taxonomic identifierⁱ	83333 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › Escherichia coli
Proteomesⁱ	UP000000318 Componentⁱ: Chromosome UP000000625 Componentⁱ: Chromosome

Organism-specific databases

EcoGeneⁱ	EG10583 metC

EcoGeneⁱ

EG10583 metC

Subcellular locationⁱ

Cytoplasm Curated

GO - Cellular componentⁱ

cytoplasm Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Disruption of the gene increases the amounts of L-cysteine and L-cystine produced after 72 hours of cultivation.1 Publication

Chemistry databases

ChEMBLⁱ	CHEMBL1075079

ChEMBLⁱ

CHEMBL1075079

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed
ChainⁱPRO_0000114768	2 – 395	Cystathionine beta-lyase MetCAdd BLAST		394

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	210	N6-(pyridoxal phosphate)lysine2 Publications		1

Proteomic databases

PaxDbⁱ	P06721
PRIDEⁱ	P06721

Interactionⁱ

Subunit structureⁱ

Homotetramer; dimer of dimers.1 Publication

Protein-protein interaction databases

BioGridⁱ	4261419, 41 interactors
Database of interacting proteins More...DIPⁱ	DIP-10193N
IntActⁱ	P06721, 6 interactors
STRINGⁱ	316385.ECDH10B_3183

Chemistry databases

BindingDBⁱ

P06721

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	6 – 12	Combined sources	7
Helixⁱ	17 – 20	Combined sources	4
Beta strandⁱ	23 – 25	Combined sources	3
Beta strandⁱ	32 – 34	Combined sources	3
Helixⁱ	39 – 47	Combined sources	9
Turnⁱ	48 – 52	Combined sources	5
Helixⁱ	57 – 59	Combined sources	3
Helixⁱ	62 – 75	Combined sources	14
Beta strandⁱ	78 – 85	Combined sources	8
Helixⁱ	86 – 97	Combined sources	12
Beta strandⁱ	103 – 107	Combined sources	5
Helixⁱ	112 – 120	Combined sources	9
Helixⁱ	122 – 125	Combined sources	4
Beta strandⁱ	128 – 132	Combined sources	5
Helixⁱ	137 – 143	Combined sources	7
Beta strandⁱ	148 – 156	Combined sources	9
Turnⁱ	158 – 160	Combined sources	3
Helixⁱ	166 – 176	Combined sources	11
Beta strandⁱ	181 – 185	Combined sources	5
Turnⁱ	187 – 192	Combined sources	6
Helixⁱ	196 – 199	Combined sources	4
Beta strandⁱ	202 – 207	Combined sources	6
Turnⁱ	208 – 213	Combined sources	6
Beta strandⁱ	215 – 217	Combined sources	3
Beta strandⁱ	221 – 225	Combined sources	5
Turnⁱ	227 – 229	Combined sources	3
Helixⁱ	230 – 239	Combined sources	10
Helixⁱ	246 – 256	Combined sources	11
Helixⁱ	259 – 278	Combined sources	20
Beta strandⁱ	283 – 287	Combined sources	5
Helixⁱ	297 – 303	Combined sources	7
Beta strandⁱ	309 – 317	Combined sources	9
Helixⁱ	321 – 328	Combined sources	8
Beta strandⁱ	342 – 344	Combined sources	3
Beta strandⁱ	346 – 350	Combined sources	5
Helixⁱ	352 – 356	Combined sources	5
Beta strandⁱ	370 – 374	Combined sources	5
Helixⁱ	380 – 392	Combined sources	13

Show more details

3D structure databases

ProteinModelPortalⁱ	P06721
SMRⁱ	P06721
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P06721

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the trans-sulfuration enzymes family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG4105C28 Bacteria COG0626 LUCA
HOGENOMⁱ	HOG000246416
InParanoidⁱ	P06721
KEGG Orthology (KO) More...KOⁱ	K01760
PhylomeDBⁱ	P06721

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00614 CGS_like, 1 hit
Gene3Dⁱ	3.40.640.10, 1 hit 3.90.1150.10, 1 hit
InterProⁱ	View protein in InterPro IPR000277 Cys/Met-Metab_PyrdxlP-dep_enz IPR006233 Cys_b_lyase_bac IPR015424 PyrdxlP-dep_Trfase IPR015422 PyrdxlP-dep_Trfase_dom1 IPR015421 PyrdxlP-dep_Trfase_major
PANTHERⁱ	PTHR43500 PTHR43500, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01053 Cys_Met_Meta_PP, 1 hit
PIRSFⁱ	PIRSF001434 CGS, 1 hit
SUPFAMⁱ	SSF53383 SSF53383, 1 hit
TIGRFAMsⁱ	TIGR01324 cysta_beta_ly_B, 1 hit
PROSITEⁱ	View protein in PROSITE PS00868 CYS_MET_METAB_PP, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P06721-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MADKKLDTQL VNAGRSKKYT LGAVNSVIQR ASSLVFDSVE AKKHATRNRA 
        60         70         80         90        100
NGELFYGRRG TLTHFSLQQA MCELEGGAGC VLFPCGAAAV ANSILAFIEQ 
       110        120        130        140        150
GDHVLMTNTA YEPSQDFCSK ILSKLGVTTS WFDPLIGADI VKHLQPNTKI 
       160        170        180        190        200
VFLESPGSIT MEVHDVPAIV AAVRSVVPDA IIMIDNTWAA GVLFKALDFG 
       210        220        230        240        250
IDVSIQAATK YLVGHSDAMI GTAVCNARCW EQLRENAYLM GQMVDADTAY 
       260        270        280        290        300
ITSRGLRTLG VRLRQHHESS LKVAEWLAEH PQVARVNHPA LPGSKGHEFW 
       310        320        330        340        350
KRDFTGSSGL FSFVLKKKLN NEELANYLDN FSLFSMAYSW GGYESLILAN 
       360        370        380        390 
QPEHIAAIRP QGEIDFSGTL IRLHIGLEDV DDLIADLDAG FARIV

Length:395

Mass (Da):43,212

Last modified:January 1, 1988 - v1

Checksum:ⁱFD3308423D6427C6

Sequence cautionⁱ

The sequence AAA69175 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M12858 Genomic DNA Translation: AAA24158.1 U28377 Genomic DNA Translation: AAA69175.1 Different initiation. U00096 Genomic DNA Translation: AAC76044.1 AP009048 Genomic DNA Translation: BAE77065.1
PIRⁱ	A25153 WZECCB
NCBI Reference Sequences More...RefSeqⁱ	NP_417481.1, NC_000913.3 WP_001301079.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaⁱ	AAC76044; AAC76044; b3008 BAE77065; BAE77065; BAE77065
GeneIDⁱ	946240
KEGGⁱ	ecj:JW2975 eco:b3008
PATRICⁱ	fig\|511145.12.peg.3102

Protein	Similar proteins		Species	Score	Length	Source
P06721	Cystathionine beta-lyase		Escherichia coli 110957		421	UniRef100_P06721
Cystathionine beta-lyase		Escherichia coli MS 198-1		421
Cystathionine beta-lyase		Escherichia coli H736		421
Cystathionine beta-lyase MetC		Shigella sp.		395
Cystathionine beta-lyase		ECOLX		395
+12

Protein	Similar proteins		Species	Score	Length	Source
P06721	Cystathionine beta-lyase		Escherichia coli 110957		421	UniRef90_P06721
Cystathionine beta-lyase		Escherichia coli MS 198-1		421
Cystathionine beta-lyase		Escherichia coli H736		421
Cystathionine beta-lyase MetC		Shigella sp.		395
Cystathionine beta-lyase		ECOLX		395
+635

Protein	Similar proteins		Species	Score	Length	Source
P06721	Cystathionine beta-lyase		SALTY		395	UniRef50_P06721
Cystathionine beta-lyase		HAEIN		396
Cystathionine beta-lyase		Escherichia coli 110957		421
Cystathionine beta-lyase		Escherichia coli MS 198-1		421
Cystathionine beta-lyase		Escherichia coli H736		421
+3828

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M12858 Genomic DNA Translation: AAA24158.1 U28377 Genomic DNA Translation: AAA69175.1 Different initiation. U00096 Genomic DNA Translation: AAC76044.1 AP009048 Genomic DNA Translation: BAE77065.1
PIRⁱ	A25153 WZECCB
RefSeqⁱ	NP_417481.1, NC_000913.3 WP_001301079.1, NZ_LN832404.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1CL1	X-ray	1.83	A/B	1-395	[»]
	1CL2	X-ray	2.20	A/B	1-395	[»]
	2FQ6	X-ray	1.78	A/B	1-395	[»]
	2GQN	X-ray	1.80	A/B	1-395	[»]
	4ITG	X-ray	1.74	A/B	1-395	[»]
	4ITX	X-ray	1.61	A/B	1-395	[»]
ProteinModelPortalⁱ	P06721
SMRⁱ	P06721
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	4261419, 41 interactors
DIPⁱ	DIP-10193N
IntActⁱ	P06721, 6 interactors
STRINGⁱ	316385.ECDH10B_3183

Chemistry databases

BindingDBⁱ	P06721
ChEMBLⁱ	CHEMBL1075079

Proteomic databases

PaxDbⁱ	P06721
PRIDEⁱ	P06721

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	AAC76044; AAC76044; b3008 BAE77065; BAE77065; BAE77065
GeneIDⁱ	946240
KEGGⁱ	ecj:JW2975 eco:b3008
PATRICⁱ	fig\|511145.12.peg.3102

Organism-specific databases

EchoBASEⁱ	EB0578
EcoGeneⁱ	EG10583 metC

Phylogenomic databases

eggNOGⁱ	ENOG4105C28 Bacteria COG0626 LUCA
HOGENOMⁱ	HOG000246416
InParanoidⁱ	P06721
KOⁱ	K01760
PhylomeDBⁱ	P06721

Enzyme and pathway databases

UniPathwayⁱ	UPA00051;UER00078
BioCycⁱ	EcoCyc:CYSTATHIONINE-BETA-LYASE-MONOMER MetaCyc:CYSTATHIONINE-BETA-LYASE-MONOMER
BRENDAⁱ	4.4.1.8 2026

Miscellaneous databases

EvolutionaryTraceⁱ	P06721
Protein Ontology More...PROⁱ	PR:P06721

Family and domain databases

CDDⁱ	cd00614 CGS_like, 1 hit
Gene3Dⁱ	3.40.640.10, 1 hit 3.90.1150.10, 1 hit
InterProⁱ	View protein in InterPro IPR000277 Cys/Met-Metab_PyrdxlP-dep_enz IPR006233 Cys_b_lyase_bac IPR015424 PyrdxlP-dep_Trfase IPR015422 PyrdxlP-dep_Trfase_dom1 IPR015421 PyrdxlP-dep_Trfase_major
PANTHERⁱ	PTHR43500 PTHR43500, 1 hit
Pfamⁱ	View protein in Pfam PF01053 Cys_Met_Meta_PP, 1 hit
PIRSFⁱ	PIRSF001434 CGS, 1 hit
SUPFAMⁱ	SSF53383 SSF53383, 1 hit
TIGRFAMsⁱ	TIGR01324 cysta_beta_ly_B, 1 hit
PROSITEⁱ	View protein in PROSITE PS00868 CYS_MET_METAB_PP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	METC_ECOLI
Accessionⁱ	P06721Primary (citable) accession number: P06721 Secondary accession number(s): Q2M9J1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
	Last sequence update:	January 1, 1988
	Last modified:	November 7, 2018
	This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Prokaryotic Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P06721 (METC_ECOLI)

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Cystathionine beta-lyase MetC

metC

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

pH dependencei

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-methionine biosynthesis via de novo pathway

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

Kineticsⁱ

pH dependenceⁱ

Pathwayⁱ: L-methionine biosynthesis via de novo pathway

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ