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Protein

Troponin C, body wall muscle

Gene
N/A
Organism
Halocynthia roretzi (Sea squirt) (Cynthia roretzi)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Troponin is the central regulatory protein of muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi57 – 681Add BLAST12
Calcium bindingi135 – 1462Add BLAST12

GO - Molecular functioni

Keywordsi

Molecular functionMuscle protein
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin C, body wall muscle
OrganismiHalocynthia roretzi (Sea squirt) (Cynthia roretzi)
Taxonomic identifieri7729 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataTunicataAscidiaceaStolidobranchiaPyuridaeHalocynthia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000736891 – 155Troponin C, body wall muscleAdd BLAST155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylvaline1 Publication1

Keywords - PTMi

Acetylation

PTM databases

iPTMnetiP06706

Structurei

3D structure databases

ProteinModelPortaliP06706
SMRiP06706
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 43EF-hand 1PROSITE-ProRule annotationAdd BLAST37
Domaini44 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini88 – 121EF-hand 3PROSITE-ProRule annotationAdd BLAST34
Domaini122 – 155EF-hand 4PROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the troponin C family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG012180

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF00036 EF-hand_1, 1 hit
PF13202 EF-hand_5, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

P06706-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VEHLTEDEKS QFRAAFDIFV ADAKDGTISS KELGKVMKML GQNPTEKDLQ
60 70 80 90 100
EMIEEVDIDG SGTIDFEEFC LMMYRQMQAQ EEAKIPEREE KELSEAFRLF
110 120 130 140 150
DLDGDGIGDE LKAALDGTGE NVETWEVDEM MADGDKNHDS QIDYEEWVTM

MKFVQ
Length:155
Mass (Da):17,749
Last modified:November 1, 1990 - v2
Checksum:iB7ED76F2DF693FB4
GO

Sequence databases

PIRiA28853

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiA28853

3D structure databases

ProteinModelPortaliP06706
SMRiP06706
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP06706

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG012180

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF00036 EF-hand_1, 1 hit
PF13202 EF-hand_5, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTNNC_HALRO
AccessioniPrimary (citable) accession number: P06706
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: November 1, 1990
Last modified: October 25, 2017
This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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