UniProtKB - P06704 (CDC31_YEAST)
Cell division control protein 31
CDC31
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 33 – 44 | 1PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 142 – 153 | 2PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: GO_Central
- identical protein binding Source: IntAct
- microtubule binding Source: GO_Central
GO - Biological processi
- cell division Source: UniProtKB-KW
- mRNA transport Source: UniProtKB-KW
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: SGD
- protein transport Source: UniProtKB-KW
- regulation of kinase activity Source: SGD
- spindle pole body duplication Source: SGD
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis, mRNA transport, Protein transport, Translocation, Transport |
Ligand | Calcium, Metal-binding |
Protein family/group databases
TCDBi | 1.I.1.1.1, the nuclear pore complex (npc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Cell division control protein 31Alternative name(s): Nuclear pore protein CDC31 Nucleoporin CDC31 |
Gene namesi | Name:CDC31 Synonyms:DSK1 Ordered Locus Names:YOR257W |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YOR257W |
SGDi | S000005783, CDC31 |
Subcellular locationi
Cytoskeleton
Nucleus
- nuclear pore complex 1 Publication
Note: Spindle pole body, SPB half- bridge.
Cytoskeleton
- half bridge of spindle pole body Source: SGD
- microtubule organizing center Source: GO_Central
- mitotic spindle pole body Source: GO_Central
Nucleus
- nuclear pore Source: UniProtKB-SubCell
- transcription export complex 2 Source: SGD
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Nuclear pore complex, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000073577 | 1 – 161 | Cell division control protein 31Add BLAST | 161 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 130 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P06704 |
PaxDbi | P06704 |
PRIDEi | P06704 |
PTM databases
iPTMneti | P06704 |
Interactioni
Subunit structurei
Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.
Component of the spindle pole body (SPB), acting as the connector of microtubule arrays in the cytoplasm and the nucleoplasm, is involved in nuclear positioning before chromosome segregation, SPB separation, spindle formation, chromosome segregation, nuclear migration into the bud, nuclear reorientation after cytokinesis and nuclear fusion during conjugation. The SPB half-bridge, which is tightly associated with the cytoplasmic side of the nuclear envelope and the SPB, is playing a key role as the starting structure for and in the initiation of SPB duplication in G1. At the SPB half-bridge CDC31 interacts with KAR1, MPS3 and SFI1. It also interacts with KIC1.
4 PublicationsBinary interactionsi
Hide detailsP06704
GO - Molecular functioni
- identical protein binding Source: IntAct
- microtubule binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 34647, 85 interactors |
ComplexPortali | CPX-1686, TREX-2 complex |
DIPi | DIP-2273N |
IntActi | P06704, 31 interactors |
MINTi | P06704 |
STRINGi | 4932.YOR257W |
Miscellaneous databases
RNActi | P06704, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P06704 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P06704 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 55 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 56 – 91 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 93 – 128 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 129 – 161 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 33 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0028, Eukaryota |
GeneTreei | ENSGT00940000157995 |
HOGENOMi | CLU_061288_18_1_1 |
InParanoidi | P06704 |
OMAi | EFFAIMT |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF13499, EF-hand_7, 2 hits |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 3 hits |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MSKNRSSLQS GPLNSELLEE QKQEIYEAFS LFDMNNDGFL DYHELKVAMK
60 70 80 90 100
ALGFELPKRE ILDLIDEYDS EGRHLMKYDD FYIVMGEKIL KRDPLDEIKR
110 120 130 140 150
AFQLFDDDHT GKISIKNLRR VAKELGETLT DEELRAMIEE FDLDGDGEIN
160
ENEFIAICTD S
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 77 | K → L in AAA66893 (PubMed:3526331).Curated | 1 | |
Sequence conflicti | 110 | T → I in AAA66893 (PubMed:3526331).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14078 Genomic DNA Translation: AAA66893.1 X74500 Genomic DNA Translation: CAA52609.1 Z75165 Genomic DNA Translation: CAA99479.1 AY558434 Genomic DNA Translation: AAS56760.1 BK006948 Genomic DNA Translation: DAA11024.1 |
PIRi | S47549 |
RefSeqi | NP_014900.3, NM_001183676.3 |
Genome annotation databases
EnsemblFungii | YOR257W_mRNA; YOR257W; YOR257W |
GeneIDi | 854431 |
KEGGi | sce:YOR257W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14078 Genomic DNA Translation: AAA66893.1 X74500 Genomic DNA Translation: CAA52609.1 Z75165 Genomic DNA Translation: CAA99479.1 AY558434 Genomic DNA Translation: AAS56760.1 BK006948 Genomic DNA Translation: DAA11024.1 |
PIRi | S47549 |
RefSeqi | NP_014900.3, NM_001183676.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DOQ | X-ray | 3.00 | A/B/C | 1-161 | [»] | |
2GV5 | X-ray | 3.00 | A/B/D/E | 1-161 | [»] | |
3FWB | X-ray | 2.50 | A | 1-161 | [»] | |
3FWC | X-ray | 2.70 | A/E/I/M | 1-161 | [»] | |
4MBE | X-ray | 2.61 | A/D | 1-161 | [»] | |
SMRi | P06704 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 34647, 85 interactors |
ComplexPortali | CPX-1686, TREX-2 complex |
DIPi | DIP-2273N |
IntActi | P06704, 31 interactors |
MINTi | P06704 |
STRINGi | 4932.YOR257W |
Protein family/group databases
TCDBi | 1.I.1.1.1, the nuclear pore complex (npc) family |
PTM databases
iPTMneti | P06704 |
Proteomic databases
MaxQBi | P06704 |
PaxDbi | P06704 |
PRIDEi | P06704 |
Genome annotation databases
EnsemblFungii | YOR257W_mRNA; YOR257W; YOR257W |
GeneIDi | 854431 |
KEGGi | sce:YOR257W |
Organism-specific databases
EuPathDBi | FungiDB:YOR257W |
SGDi | S000005783, CDC31 |
Phylogenomic databases
eggNOGi | KOG0028, Eukaryota |
GeneTreei | ENSGT00940000157995 |
HOGENOMi | CLU_061288_18_1_1 |
InParanoidi | P06704 |
OMAi | EFFAIMT |
Miscellaneous databases
EvolutionaryTracei | P06704 |
PROi | PR:P06704 |
RNActi | P06704, protein |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF13499, EF-hand_7, 2 hits |
SMARTi | View protein in SMART SM00054, EFh, 4 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CDC31_YEAST | |
Accessioni | P06704Primary (citable) accession number: P06704 Secondary accession number(s): D6W2V8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | February 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 210 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast chromosome XV
Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD