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Protein

Protein S100-A6

Gene

S100A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.1 Publication

Miscellaneous

This protein co-purified with the prolactin receptor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331Add BLAST14
Calcium bindingi61 – 722Add BLAST12

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB
  • calcium ion binding Source: UniProtKB
  • ion transmembrane transporter activity Source: Ensembl
  • protein homodimerization activity Source: UniProtKB
  • S100 protein binding Source: UniProtKB
  • tropomyosin binding Source: UniProtKB
  • zinc ion binding Source: Ensembl

GO - Biological processi

  • axonogenesis Source: UniProtKB
  • positive regulation of fibroblast proliferation Source: UniProtKB
  • signal transduction Source: UniProtKB

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

SIGNORiP06703

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A6
Alternative name(s):
Calcyclin
Growth factor-inducible protein 2A9
MLN 4
Prolactin receptor-associated protein
Short name:
PRA
S100 calcium-binding protein A6
Gene namesi
Name:S100A6
Synonyms:CACY
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000197956.9
HGNCiHGNC:10496 S100A6
MIMi114110 gene
neXtProtiNX_P06703

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6277
OpenTargetsiENSG00000197956
PharmGKBiPA34908

Polymorphism and mutation databases

BioMutaiS100A6
DMDMi116509

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001439841 – 90Protein S100-A6Add BLAST90

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40N6-acetyllysineCombined sources1
Modified residuei46PhosphoserineCombined sources1
Modified residuei47N6-acetyllysine; alternateBy similarity1
Modified residuei47N6-succinyllysine; alternateBy similarity1

Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP06703
MaxQBiP06703
PaxDbiP06703
PeptideAtlasiP06703
PRIDEiP06703
ProteomicsDBi51911
TopDownProteomicsiP06703

2D gel databases

DOSAC-COBS-2DPAGEiP06703

PTM databases

iPTMnetiP06703
PhosphoSitePlusiP06703
SwissPalmiP06703

Expressioni

Inductioni

Preferentially expressed when quiescent fibroblasts are stimulated to proliferate. It is inducible by growth factors and overexpressed in acute myeloid leukemias.

Gene expression databases

BgeeiENSG00000197956
CleanExiHS_S100A6
ExpressionAtlasiP06703 baseline and differential
GenevisibleiP06703 HS

Organism-specific databases

HPAiCAB002601
CAB040549
CAB047354
HPA007575

Interactioni

Subunit structurei

Homodimer; head to tail assembly of 2 subunits. Interacts with CACYBP in a calcium-dependent manner. Interacts with ANXA2 and ANXA11 (via N-terminus). Interacts with SUGT1. Interacts with TP53; has higher affinity for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain. Interacts with tropomyosin. Interacts with FKBP4. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.6 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • S100 protein binding Source: UniProtKB
  • tropomyosin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112185, 32 interactors
CORUMiP06703
IntActiP06703, 21 interactors
MINTiP06703
STRINGi9606.ENSP00000357708

Structurei

Secondary structure

190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 20Combined sources17
Beta strandi22 – 24Combined sources3
Beta strandi28 – 30Combined sources3
Helixi31 – 41Combined sources11
Helixi45 – 47Combined sources3
Helixi51 – 62Combined sources12
Turni63 – 65Combined sources3
Beta strandi67 – 69Combined sources3
Helixi70 – 84Combined sources15
Helixi86 – 88Combined sources3

3D structure databases

ProteinModelPortaliP06703
SMRiP06703
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06703

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini48 – 83EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IYT5 Eukaryota
ENOG410Z6I6 LUCA
GeneTreeiENSGT00760000119034
HOGENOMiHOG000246968
HOVERGENiHBG001479
InParanoidiP06703
OMAiQVVNFQE
OrthoDBiEOG091G10JX
PhylomeDBiP06703
TreeFamiTF332727

Family and domain databases

CDDicd05029 S-100A6, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR034118 S-100A6
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PfamiView protein in Pfam
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 1 hit
PS00303 S100_CABP, 1 hit

Sequencei

Sequence statusi: Complete.

P06703-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACPLDQAIG LLVAIFHKYS GREGDKHTLS KKELKELIQK ELTIGSKLQD
60 70 80 90
AEIARLMEDL DRNKDQEVNF QEYVTFLGAL ALIYNEALKG
Length:90
Mass (Da):10,180
Last modified:January 1, 1988 - v1
Checksum:i860CBB1416ACBCA1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01198227H → R. Corresponds to variant dbSNP:rs11974Ensembl.1
Natural variantiVAR_01198369N → S. Corresponds to variant dbSNP:rs1802581Ensembl.1
Natural variantiVAR_01198483I → T. Corresponds to variant dbSNP:rs1802582Ensembl.1
Natural variantiVAR_02928190G → D. Corresponds to variant dbSNP:rs2228293Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14300 mRNA Translation: AAA35886.1
J02763 Genomic DNA Translation: AAA51905.1
M18981 mRNA Translation: AAA51906.1
AY034480 Genomic DNA Translation: AAK59702.1
BT006965 mRNA Translation: AAP35611.1
BX470102 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53318.1
CH471121 Genomic DNA Translation: EAW53320.1
CH471121 Genomic DNA Translation: EAW53321.1
CH471121 Genomic DNA Translation: EAW53322.1
CH471121 Genomic DNA Translation: EAW53323.1
CH471121 Genomic DNA Translation: EAW53324.1
CH471121 Genomic DNA Translation: EAW53325.1
CH471121 Genomic DNA Translation: EAW53326.1
BC001431 mRNA Translation: AAH01431.1
BC009017 mRNA Translation: AAH09017.1
CCDSiCCDS1040.1
PIRiA28363 BCHUY
RefSeqiNP_055439.1, NM_014624.3
XP_016857522.1, XM_017002033.1
UniGeneiHs.275243

Genome annotation databases

EnsembliENST00000368719; ENSP00000357708; ENSG00000197956
ENST00000368720; ENSP00000357709; ENSG00000197956
ENST00000496817; ENSP00000473589; ENSG00000197956
GeneIDi6277
KEGGihsa:6277
UCSCiuc001fbw.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiS10A6_HUMAN
AccessioniPrimary (citable) accession number: P06703
Secondary accession number(s): D3DV39, Q5RHS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: July 18, 2018
This is version 187 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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