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UniProtKB - P06703 (S10A6_HUMAN)

Entry version 203 (07 Oct 2020)
Sequence version 1 (01 Jan 1988)
Previous versions | rss
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Protein

Protein S100-A6

Gene

S100A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative.1 Publication

Miscellaneous

This protein co-purified with the prolactin receptor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi20 – 331Add BLAST14
Calcium bindingi61 – 722Add BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P06703

SIGNOR Signaling Network Open Resource

More...SIGNORi		P06703

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein S100-A6
Alternative name(s):
Calcyclin
Growth factor-inducible protein 2A9
MLN 4
Prolactin receptor-associated protein
Short name:
PRA
S100 calcium-binding protein A6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:S100A6
Synonyms:CACY
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000197956.9

Human Gene Nomenclature Database

More...HGNCi		HGNC:10496, S100A6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		114110, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P06703

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6277

Open Targets

More...OpenTargetsi		ENSG00000197956

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34908

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P06703, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB11093, Calcium citrate
DB11348, Calcium Phosphate
DB14481, Calcium phosphate dihydrate

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		S100A6

Domain mapping of disease mutations (DMDM)

More...DMDMi		116509

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001439841 – 90Protein S100-A6Add BLAST90

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei40N6-acetyllysineCombined sources1
Modified residuei46PhosphoserineCombined sources1
Modified residuei47N6-acetyllysine; alternateBy similarity1
Modified residuei47N6-succinyllysine; alternateBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P06703

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P06703

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P06703

MaxQB - The MaxQuant DataBase

More...MaxQBi		P06703

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P06703

PeptideAtlas

More...PeptideAtlasi		P06703

PRoteomics IDEntifications database

More...PRIDEi		P06703

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51911

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P06703

2D gel databases

DOSAC-COBS 2D-PAGE database

More...DOSAC-COBS-2DPAGEi		P06703

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P06703

MetOSite database of methionine sulfoxide sites

More...MetOSitei		P06703

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P06703

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P06703

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Preferentially expressed when quiescent fibroblasts are stimulated to proliferate. It is inducible by growth factors and overexpressed in acute myeloid leukemias.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000197956, Expressed in calcaneal tendon and 235 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P06703, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P06703, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000197956, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; head to tail assembly of 2 subunits.

Interacts with CACYBP in a calcium-dependent manner.

Interacts with ANXA2 and ANXA11 (via N-terminus).

Interacts with SUGT1.

Interacts with TP53; has higher affinity for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain.

Interacts with tropomyosin.

Interacts with FKBP4.

Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112185, 47 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P06703

Protein interaction database and analysis system

More...IntActi		P06703, 39 interactors

Molecular INTeraction database

More...MINTi		P06703

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000357709

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P06703, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P06703

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P06703

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P06703

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini12 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini48 – 83EF-hand 2PROSITE-ProRule annotationAdd BLAST36

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S6IN, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161896

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P06703

KEGG Orthology (KO)

More...KOi		K23764

Identification of Orthologs from Complete Genome Data

More...OMAi		TEMCHEY

Database of Orthologous Groups

More...OrthoDBi		1581517at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P06703

TreeFam database of animal gene trees

More...TreeFami		TF332727

Family and domain databases

Conserved Domains Database

More...CDDi		cd05029, S-100A6, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR034118, S-100A6
IPR001751, S100/CaBP-9k_CS
IPR013787, S100_Ca-bd_sub

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01023, S_100, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00054, EFh, 1 hit
SM01394, S_100, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 1 hit
PS00303, S100_CABP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P06703-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACPLDQAIG LLVAIFHKYS GREGDKHTLS KKELKELIQK ELTIGSKLQD 
        60         70         80         90
AEIARLMEDL DRNKDQEVNF QEYVTFLGAL ALIYNEALKG
Length:90
Mass (Da):10,180
Last modified:January 1, 1988 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i860CBB1416ACBCA1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GN98R4GN98_HUMAN
Protein S100
S100A6
85Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01198227H → R. Corresponds to variant dbSNP:rs11974Ensembl.1
Natural variantiVAR_01198369N → S. Corresponds to variant dbSNP:rs1802581Ensembl.1
Natural variantiVAR_01198483I → T. Corresponds to variant dbSNP:rs1802582Ensembl.1
Natural variantiVAR_02928190G → D. Corresponds to variant dbSNP:rs2228293EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M14300 mRNA Translation: AAA35886.1
J02763 Genomic DNA Translation: AAA51905.1
M18981 mRNA Translation: AAA51906.1
AY034480 Genomic DNA Translation: AAK59702.1
BT006965 mRNA Translation: AAP35611.1
BX470102 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53318.1
CH471121 Genomic DNA Translation: EAW53320.1
CH471121 Genomic DNA Translation: EAW53321.1
CH471121 Genomic DNA Translation: EAW53322.1
CH471121 Genomic DNA Translation: EAW53323.1
CH471121 Genomic DNA Translation: EAW53324.1
CH471121 Genomic DNA Translation: EAW53325.1
CH471121 Genomic DNA Translation: EAW53326.1
BC001431 mRNA Translation: AAH01431.1
BC009017 mRNA Translation: AAH09017.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1040.1

Protein sequence database of the Protein Information Resource

More...PIRi		A28363, BCHUY

NCBI Reference Sequences

More...RefSeqi		NP_055439.1, NM_014624.3
XP_016857522.1, XM_017002033.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000368719; ENSP00000357708; ENSG00000197956
ENST00000368720; ENSP00000357709; ENSG00000197956
ENST00000496817; ENSP00000473589; ENSG00000197956

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6277

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6277

UCSC genome browser

More...UCSCi		uc001fbw.2, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14300 mRNA Translation: AAA35886.1
J02763 Genomic DNA Translation: AAA51905.1
M18981 mRNA Translation: AAA51906.1
AY034480 Genomic DNA Translation: AAK59702.1
BT006965 mRNA Translation: AAP35611.1
BX470102 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53318.1
CH471121 Genomic DNA Translation: EAW53320.1
CH471121 Genomic DNA Translation: EAW53321.1
CH471121 Genomic DNA Translation: EAW53322.1
CH471121 Genomic DNA Translation: EAW53323.1
CH471121 Genomic DNA Translation: EAW53324.1
CH471121 Genomic DNA Translation: EAW53325.1
CH471121 Genomic DNA Translation: EAW53326.1
BC001431 mRNA Translation: AAH01431.1
BC009017 mRNA Translation: AAH09017.1
CCDSiCCDS1040.1
PIRiA28363, BCHUY
RefSeqiNP_055439.1, NM_014624.3
XP_016857522.1, XM_017002033.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K8UX-ray1.15A1-90[»]
1K96X-ray1.44A1-90[»]
1K9KX-ray1.76A/B1-90[»]
1K9PX-ray1.90A1-90[»]
2M1KNMR-B/D1-90[»]
4YBHX-ray2.40B1-90[»]
BMRBiP06703
SMRiP06703
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112185, 47 interactors
CORUMiP06703
IntActiP06703, 39 interactors
MINTiP06703
STRINGi9606.ENSP00000357709

Chemistry databases

DrugBankiDB11093, Calcium citrate
DB11348, Calcium Phosphate
DB14481, Calcium phosphate dihydrate

PTM databases

iPTMnetiP06703
MetOSiteiP06703
PhosphoSitePlusiP06703
SwissPalmiP06703

Polymorphism and mutation databases

BioMutaiS100A6
DMDMi116509

2D gel databases

DOSAC-COBS-2DPAGEiP06703

Proteomic databases

EPDiP06703
jPOSTiP06703
MassIVEiP06703
MaxQBiP06703
PaxDbiP06703
PeptideAtlasiP06703
PRIDEiP06703
ProteomicsDBi51911
TopDownProteomicsiP06703

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1680, 495 antibodies

The CPTC Antibody Portal

More...CPTCi		P06703, 3 antibodies

The DNASU plasmid repository

More...DNASUi		6277

Genome annotation databases

EnsembliENST00000368719; ENSP00000357708; ENSG00000197956
ENST00000368720; ENSP00000357709; ENSG00000197956
ENST00000496817; ENSP00000473589; ENSG00000197956
GeneIDi6277
KEGGihsa:6277
UCSCiuc001fbw.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6277
DisGeNETi6277
EuPathDBiHostDB:ENSG00000197956.9

GeneCards: human genes, protein and diseases

More...GeneCardsi		S100A6
HGNCiHGNC:10496, S100A6
HPAiENSG00000197956, Low tissue specificity
MIMi114110, gene
neXtProtiNX_P06703
OpenTargetsiENSG00000197956
PharmGKBiPA34908

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S6IN, Eukaryota
GeneTreeiENSGT00940000161896
InParanoidiP06703
KOiK23764
OMAiTEMCHEY
OrthoDBi1581517at2759
PhylomeDBiP06703
TreeFamiTF332727

Enzyme and pathway databases

PathwayCommonsiP06703
SIGNORiP06703

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6277, 7 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		S100A6, human
EvolutionaryTraceiP06703

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		S100A6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6277
PharosiP06703, Tbio

Protein Ontology

More...PROi		PR:P06703
RNActiP06703, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000197956, Expressed in calcaneal tendon and 235 other tissues
ExpressionAtlasiP06703, baseline and differential
GenevisibleiP06703, HS

Family and domain databases

CDDicd05029, S-100A6, 1 hit
InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR034118, S-100A6
IPR001751, S100/CaBP-9k_CS
IPR013787, S100_Ca-bd_sub
PfamiView protein in Pfam
PF01023, S_100, 1 hit
SMARTiView protein in SMART
SM00054, EFh, 1 hit
SM01394, S_100, 1 hit
SUPFAMiSSF47473, SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 1 hit
PS00303, S100_CABP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS10A6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06703
Secondary accession number(s): D3DV39, Q5RHS4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: October 7, 2020
This is version 203 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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