UniProtKB - P06703 (S10A6_HUMAN)
Protein S100-A6
S100A6
Functioni
Miscellaneous
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 20 – 33 | 1Add BLAST | 14 | |
Calcium bindingi | 61 – 72 | 2Add BLAST | 12 |
GO - Molecular functioni
- calcium-dependent protein binding Source: UniProtKB
- calcium ion binding Source: UniProtKB
- ion transmembrane transporter activity Source: Ensembl
- protein homodimerization activity Source: UniProtKB
- S100 protein binding Source: UniProtKB
- tropomyosin binding Source: UniProtKB
- zinc ion binding Source: Ensembl
GO - Biological processi
- axonogenesis Source: UniProtKB
- positive regulation of fibroblast proliferation Source: UniProtKB
- signal transduction Source: UniProtKB
Keywordsi
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | P06703 |
SIGNORi | P06703 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein S100-A6Alternative name(s): Calcyclin Growth factor-inducible protein 2A9 MLN 4 Prolactin receptor-associated protein Short name: PRA S100 calcium-binding protein A6 |
Gene namesi | Name:S100A6 Synonyms:CACY |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10496, S100A6 |
MIMi | 114110, gene |
neXtProti | NX_P06703 |
VEuPathDBi | HostDB:ENSG00000197956.9 |
Subcellular locationi
Nucleus
Plasma membrane
Other locations
Cytosol
- cytosol Source: UniProtKB
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular exosome Source: UniProtKB
- extracellular region Source: BHF-UCL
Nucleus
- nuclear envelope Source: UniProtKB
- nucleus Source: UniProtKB
Plasma Membrane
- extrinsic component of cytoplasmic side of plasma membrane Source: UniProtKB
- plasma membrane Source: HPA
Other locations
- cytoplasm Source: UniProtKB
- perinuclear region of cytoplasm Source: UniProtKB
- ruffle Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 6277 |
OpenTargetsi | ENSG00000197956 |
PharmGKBi | PA34908 |
Miscellaneous databases
Pharosi | P06703, Tbio |
Chemistry databases
DrugBanki | DB11093, Calcium citrate DB11348, Calcium Phosphate DB14481, Calcium phosphate dihydrate |
Genetic variation databases
BioMutai | S100A6 |
DMDMi | 116509 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000143984 | 1 – 90 | Protein S100-A6Add BLAST | 90 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 40 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 46 | PhosphoserineCombined sources | 1 | |
Modified residuei | 47 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 47 | N6-succinyllysine; alternateBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P06703 |
jPOSTi | P06703 |
MassIVEi | P06703 |
MaxQBi | P06703 |
PaxDbi | P06703 |
PeptideAtlasi | P06703 |
PRIDEi | P06703 |
ProteomicsDBi | 51911 |
TopDownProteomicsi | P06703 |
2D gel databases
DOSAC-COBS-2DPAGEi | P06703 |
PTM databases
iPTMneti | P06703 |
MetOSitei | P06703 |
PhosphoSitePlusi | P06703 |
SwissPalmi | P06703 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSG00000197956, Expressed in calcaneal tendon and 235 other tissues |
ExpressionAtlasi | P06703, baseline and differential |
Genevisiblei | P06703, HS |
Organism-specific databases
HPAi | ENSG00000197956, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer; head to tail assembly of 2 subunits.
Interacts with CACYBP in a calcium-dependent manner.
Interacts with ANXA2 and ANXA11 (via N-terminus).
Interacts with SUGT1.
Interacts with TP53; has higher affinity for TP53 that is phosphorylated on its N-terminal domain, and lower affinity for TP53 that is phosphorylated on its C-terminal domain.
Interacts with tropomyosin.
Interacts with FKBP4.
Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.
7 PublicationsBinary interactionsi
Hide detailsP06703
GO - Molecular functioni
- calcium-dependent protein binding Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
- S100 protein binding Source: UniProtKB
- tropomyosin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 112185, 51 interactors |
CORUMi | P06703 |
IntActi | P06703, 41 interactors |
MINTi | P06703 |
STRINGi | 9606.ENSP00000357709 |
Miscellaneous databases
RNActi | P06703, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P06703 |
SMRi | P06703 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P06703 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 12 – 47 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 48 – 83 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502S6IN, Eukaryota |
GeneTreei | ENSGT00940000161896 |
InParanoidi | P06703 |
OMAi | TEMCHEY |
OrthoDBi | 1581517at2759 |
PhylomeDBi | P06703 |
TreeFami | TF332727 |
Family and domain databases
CDDi | cd05029, S-100A6, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR034118, S-100A6 IPR001751, S100/CaBP-9k_CS IPR013787, S100_Ca-bd_sub |
Pfami | View protein in Pfam PF01023, S_100, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 1 hit SM01394, S_100, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 1 hit PS00303, S100_CABP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MACPLDQAIG LLVAIFHKYS GREGDKHTLS KKELKELIQK ELTIGSKLQD
60 70 80 90
AEIARLMEDL DRNKDQEVNF QEYVTFLGAL ALIYNEALKG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketR4GN98 | R4GN98_HUMAN | Protein S100 | S100A6 | 85 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_011982 | 27 | H → R. Corresponds to variant dbSNP:rs11974Ensembl. | 1 | |
Natural variantiVAR_011983 | 69 | N → S. Corresponds to variant dbSNP:rs1802581Ensembl. | 1 | |
Natural variantiVAR_011984 | 83 | I → T. Corresponds to variant dbSNP:rs1802582Ensembl. | 1 | |
Natural variantiVAR_029281 | 90 | G → D. Corresponds to variant dbSNP:rs2228293EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14300 mRNA Translation: AAA35886.1 J02763 Genomic DNA Translation: AAA51905.1 M18981 mRNA Translation: AAA51906.1 AY034480 Genomic DNA Translation: AAK59702.1 BT006965 mRNA Translation: AAP35611.1 BX470102 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53318.1 CH471121 Genomic DNA Translation: EAW53320.1 CH471121 Genomic DNA Translation: EAW53321.1 CH471121 Genomic DNA Translation: EAW53322.1 CH471121 Genomic DNA Translation: EAW53323.1 CH471121 Genomic DNA Translation: EAW53324.1 CH471121 Genomic DNA Translation: EAW53325.1 CH471121 Genomic DNA Translation: EAW53326.1 BC001431 mRNA Translation: AAH01431.1 BC009017 mRNA Translation: AAH09017.1 |
CCDSi | CCDS1040.1 |
PIRi | A28363, BCHUY |
RefSeqi | NP_055439.1, NM_014624.3 XP_016857522.1, XM_017002033.1 |
Genome annotation databases
Ensembli | ENST00000368719; ENSP00000357708; ENSG00000197956 ENST00000368720; ENSP00000357709; ENSG00000197956 ENST00000496817; ENSP00000473589; ENSG00000197956 |
GeneIDi | 6277 |
KEGGi | hsa:6277 |
UCSCi | uc001fbw.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M14300 mRNA Translation: AAA35886.1 J02763 Genomic DNA Translation: AAA51905.1 M18981 mRNA Translation: AAA51906.1 AY034480 Genomic DNA Translation: AAK59702.1 BT006965 mRNA Translation: AAP35611.1 BX470102 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53318.1 CH471121 Genomic DNA Translation: EAW53320.1 CH471121 Genomic DNA Translation: EAW53321.1 CH471121 Genomic DNA Translation: EAW53322.1 CH471121 Genomic DNA Translation: EAW53323.1 CH471121 Genomic DNA Translation: EAW53324.1 CH471121 Genomic DNA Translation: EAW53325.1 CH471121 Genomic DNA Translation: EAW53326.1 BC001431 mRNA Translation: AAH01431.1 BC009017 mRNA Translation: AAH09017.1 |
CCDSi | CCDS1040.1 |
PIRi | A28363, BCHUY |
RefSeqi | NP_055439.1, NM_014624.3 XP_016857522.1, XM_017002033.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1K8U | X-ray | 1.15 | A | 1-90 | [»] | |
1K96 | X-ray | 1.44 | A | 1-90 | [»] | |
1K9K | X-ray | 1.76 | A/B | 1-90 | [»] | |
1K9P | X-ray | 1.90 | A | 1-90 | [»] | |
2M1K | NMR | - | B/D | 1-90 | [»] | |
4YBH | X-ray | 2.40 | B | 1-90 | [»] | |
BMRBi | P06703 | |||||
SMRi | P06703 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112185, 51 interactors |
CORUMi | P06703 |
IntActi | P06703, 41 interactors |
MINTi | P06703 |
STRINGi | 9606.ENSP00000357709 |
Chemistry databases
DrugBanki | DB11093, Calcium citrate DB11348, Calcium Phosphate DB14481, Calcium phosphate dihydrate |
PTM databases
iPTMneti | P06703 |
MetOSitei | P06703 |
PhosphoSitePlusi | P06703 |
SwissPalmi | P06703 |
Genetic variation databases
BioMutai | S100A6 |
DMDMi | 116509 |
2D gel databases
DOSAC-COBS-2DPAGEi | P06703 |
Proteomic databases
EPDi | P06703 |
jPOSTi | P06703 |
MassIVEi | P06703 |
MaxQBi | P06703 |
PaxDbi | P06703 |
PeptideAtlasi | P06703 |
PRIDEi | P06703 |
ProteomicsDBi | 51911 |
TopDownProteomicsi | P06703 |
Protocols and materials databases
Antibodypediai | 1680, 498 antibodies |
CPTCi | P06703, 3 antibodies |
DNASUi | 6277 |
Genome annotation databases
Ensembli | ENST00000368719; ENSP00000357708; ENSG00000197956 ENST00000368720; ENSP00000357709; ENSG00000197956 ENST00000496817; ENSP00000473589; ENSG00000197956 |
GeneIDi | 6277 |
KEGGi | hsa:6277 |
UCSCi | uc001fbw.2, human |
Organism-specific databases
CTDi | 6277 |
DisGeNETi | 6277 |
GeneCardsi | S100A6 |
HGNCi | HGNC:10496, S100A6 |
HPAi | ENSG00000197956, Low tissue specificity |
MIMi | 114110, gene |
neXtProti | NX_P06703 |
OpenTargetsi | ENSG00000197956 |
PharmGKBi | PA34908 |
VEuPathDBi | HostDB:ENSG00000197956.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S6IN, Eukaryota |
GeneTreei | ENSGT00940000161896 |
InParanoidi | P06703 |
OMAi | TEMCHEY |
OrthoDBi | 1581517at2759 |
PhylomeDBi | P06703 |
TreeFami | TF332727 |
Enzyme and pathway databases
PathwayCommonsi | P06703 |
SIGNORi | P06703 |
Miscellaneous databases
BioGRID-ORCSi | 6277, 9 hits in 875 CRISPR screens |
ChiTaRSi | S100A6, human |
EvolutionaryTracei | P06703 |
GeneWikii | S100A6 |
GenomeRNAii | 6277 |
Pharosi | P06703, Tbio |
PROi | PR:P06703 |
RNActi | P06703, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197956, Expressed in calcaneal tendon and 235 other tissues |
ExpressionAtlasi | P06703, baseline and differential |
Genevisiblei | P06703, HS |
Family and domain databases
CDDi | cd05029, S-100A6, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR034118, S-100A6 IPR001751, S100/CaBP-9k_CS IPR013787, S100_Ca-bd_sub |
Pfami | View protein in Pfam PF01023, S_100, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 1 hit SM01394, S_100, 1 hit |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 1 hit PS50222, EF_HAND_2, 1 hit PS00303, S100_CABP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S10A6_HUMAN | |
Accessioni | P06703Primary (citable) accession number: P06703 Secondary accession number(s): D3DV39, Q5RHS4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | January 1, 1988 | |
Last modified: | February 10, 2021 | |
This is version 205 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families