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Entry version 191 (25 May 2022)
Sequence version 6 (23 Jan 2007)
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Protein

Regulatory protein SIR3

Gene

SIR3

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.

Miscellaneous

Present with 1400 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulatory protein SIR3
Alternative name(s):
Silent information regulator 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SIR3
Synonyms:CMT1, MAR2, STE8
Ordered Locus Names:YLR442C
ORF Names:L9753.10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XII

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000004434, SIR3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YLR442C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2A → G: No acetylation, reduced silencing activity. 1 Publication1
Mutagenesisi2A → Q: No acetylation, No silencing activity. 1 Publication1
Mutagenesisi2A → S: No effect. 1 Publication1
Mutagenesisi2A → T: Reduced silencing activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000977682 – 978Regulatory protein SIR3Add BLAST977

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-terminal acetylation by NatA is important for transcriptional silencing activity.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P06701

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P06701

PRoteomics IDEntifications database

More...
PRIDEi
P06701

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P06701

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P06701

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer and interacts with SIR4 and RAP1 C-terminus.

Interacts with MCM10.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
31701, 112 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1811, Sir2-3-4 silent chromatin complex

Database of interacting proteins

More...
DIPi
DIP-595N

Protein interaction database and analysis system

More...
IntActi
P06701, 46 interactors

Molecular INTeraction database

More...
MINTi
P06701

STRING: functional protein association networks

More...
STRINGi
4932.YLR442C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P06701, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1978
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
P06701

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P06701

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P06701

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini48 – 188BAHPROSITE-ProRule annotationAdd BLAST141

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni218 – 304DisorderedSequence analysisAdd BLAST87
Regioni319 – 388DisorderedSequence analysisAdd BLAST70

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi225 – 252Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi256 – 303Polar residuesSequence analysisAdd BLAST48
Compositional biasi319 – 347Polar residuesSequence analysisAdd BLAST29
Compositional biasi370 – 384Acidic residuesSequence analysisAdd BLAST15

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1514, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063498

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012774_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P06701

Identification of Orthologs from Complete Genome Data

More...
OMAi
SANTHYD

Family and domain databases

Database of protein disorder

More...
DisProti
DP00533

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.490, 1 hit
3.40.50.300, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...
IDEALi
IID50067

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041083, AAA_lid_10
IPR001025, BAH_dom
IPR043151, BAH_sf
IPR020793, ORC1
IPR027417, P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR10763:SF23, PTHR10763:SF23, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17872, AAA_lid_10, 1 hit
PF01426, BAH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00439, BAH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51038, BAH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P06701-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKTLKDLDG WQVIITDDQG RVIDDNNRRR SRKRGGENVF LKRISDGLSF
60 70 80 90 100
GKGESVIFND NVTETYSVYL IHEIRLNTLN NVVEIWVFSY LRWFELKPKL
110 120 130 140 150
YYEQFRPDLI KEDHPLEFYK DKFFNEVNKS ELYLTAELSE IWLKDFIAVG
160 170 180 190 200
QILPESQWND SSIDKIEDRD FLVRYACEPT AEKFVPIDIF QIIRRVKEME
210 220 230 240 250
PKQSDEYLKR VSVPVSGQKT NRQVMHKMGV ERSSKRLAKK PSMKKIKIEP
260 270 280 290 300
SADDDVNNGN IPSQRGTSTT HGSISPQEES VSPNISSASP SALTSPTDSS
310 320 330 340 350
KILQKRSISK ELIVSEEIPI NSSEQESDYE PNNETSVLSS KPGSKPEKTS
360 370 380 390 400
TELVDGRENF VYANNPEVSD DGGLEEETDE VSSESSDEAI IPVNKRRGAH
410 420 430 440 450
GSELSSKIRK IHIQETQEFS KNYTTETDNE MNGNGKPGIP RGNTKIHSMN
460 470 480 490 500
ENPTPEKGNA KMIDFATLSK LKKKYQIILD RFAPDNQVTD SSQLNKLTDE
510 520 530 540 550
QSSLDVAGLE DKFRKACSSS GRETILSNFN ADINLEESIR ESLQKRELLK
560 570 580 590 600
SQVEDFTRIF LPIYDSLMSS QNKLFYITNA DDSTKFQLVN DVMDELITSS
610 620 630 640 650
ARKELPIFDY IHIDALELAG MDALYEKIWF AISKENLCGD ISLEALNFYI
660 670 680 690 700
TNVPKAKKRK TLILIQNPEN LLSEKILQYF EKWISSKNSK LSIICVGGHN
710 720 730 740 750
VTIREQINIM PSLKAHFTEI KLNKVDKNEL QQMIITRLKS LLKPFHVKVN
760 770 780 790 800
DKKEMTIYNN IREGQNQKIP DNVIVINHKI NNKITQLIAK NVANVSGSTE
810 820 830 840 850
KAFKICEAAV EISKKDFVRK GGLQKGKLVV SQEMVPRYFS EAINGFKDET
860 870 880 890 900
ISKKIIGMSL LMRTFLYTLA QETEGTNRHT LALETVLIKM VKMLRDNPGY
910 920 930 940 950
KASKEIKKVI CGAWEPAITI EKLKQFSWIS VVNDLVGEKL VVVVLEEPSA
960 970
SIMVELKLPL EINYAFSMDE EFKNMDCI
Length:978
Mass (Da):111,360
Last modified:January 23, 2007 - v6
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA2503D7645397AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti74I → T in AAT93176 (PubMed:17322287).Curated1
Sequence conflicti331P → S in CAA25668 (PubMed:6098447).Curated1
Sequence conflicti335T → P in CAA25668 (PubMed:6098447).Curated1
Sequence conflicti405S → G in CAA25668 (PubMed:6098447).Curated1
Sequence conflicti421K → Q in CAA25668 (PubMed:6098447).Curated1
Sequence conflicti429 – 430NE → KK in CAA25668 (PubMed:6098447).Curated2
Sequence conflicti497L → V in CAA25668 (PubMed:6098447).Curated1
Sequence conflicti587Q → R in CAA25668 (PubMed:6098447).Curated1
Sequence conflicti597I → V in CAA25668 (PubMed:6098447).Curated1
Sequence conflicti669E → D in CAA25668 (PubMed:6098447).Curated1
Sequence conflicti704R → G in CAA25668 (PubMed:6098447).Curated1
Sequence conflicti712S → T in CAA25668 (PubMed:6098447).Curated1
Sequence conflicti726D → N in CAA25668 (PubMed:6098447).Curated1
Sequence conflicti828L → F (PubMed:6098447).Curated1
Sequence conflicti830V → L (PubMed:6098447).Curated1
Sequence conflicti925Q → K in CAA25668 (PubMed:6098447).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X01420 Genomic DNA Translation: CAA25668.1
U21094 Genomic DNA Translation: AAB67522.1
AY693157 Genomic DNA Translation: AAT93176.1
BK006945 Genomic DNA Translation: DAA09743.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S59410, RGBYI3

NCBI Reference Sequences

More...
RefSeqi
NP_013547.3, NM_001182330.3

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YLR442C_mRNA; YLR442C; YLR442C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851163

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YLR442C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01420 Genomic DNA Translation: CAA25668.1
U21094 Genomic DNA Translation: AAB67522.1
AY693157 Genomic DNA Translation: AAT93176.1
BK006945 Genomic DNA Translation: DAA09743.1
PIRiS59410, RGBYI3
RefSeqiNP_013547.3, NM_001182330.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FL7X-ray1.85A1-229[»]
2FVUX-ray2.00A/B1-219[»]
3OWTX-ray2.00C456-481[»]
3TE6X-ray2.80A/B530-845[»]
3TU4X-ray3.00K/L1-213[»]
3ZCOX-ray2.70A840-978[»]
4JJNX-ray3.09K/L2-382[»]
4KUDX-ray3.20K/L2-219[»]
4KUIX-ray1.85A2-219[»]
4KULX-ray2.62A2-219[»]
4LD9X-ray3.31K/L2-229[»]
AlphaFoldDBiP06701
SMRiP06701
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi31701, 112 interactors
ComplexPortaliCPX-1811, Sir2-3-4 silent chromatin complex
DIPiDIP-595N
IntActiP06701, 46 interactors
MINTiP06701
STRINGi4932.YLR442C

PTM databases

CarbonylDBiP06701
iPTMnetiP06701

Proteomic databases

MaxQBiP06701
PaxDbiP06701
PRIDEiP06701

Genome annotation databases

EnsemblFungiiYLR442C_mRNA; YLR442C; YLR442C
GeneIDi851163
KEGGisce:YLR442C

Organism-specific databases

SGDiS000004434, SIR3
VEuPathDBiFungiDB:YLR442C

Phylogenomic databases

eggNOGiKOG1514, Eukaryota
GeneTreeiENSGT00530000063498
HOGENOMiCLU_012774_1_1_1
InParanoidiP06701
OMAiSANTHYD

Miscellaneous databases

EvolutionaryTraceiP06701

Protein Ontology

More...
PROi
PR:P06701
RNActiP06701, protein

Family and domain databases

DisProtiDP00533
Gene3Di2.30.30.490, 1 hit
3.40.50.300, 1 hit
IDEALiIID50067
InterProiView protein in InterPro
IPR041083, AAA_lid_10
IPR001025, BAH_dom
IPR043151, BAH_sf
IPR020793, ORC1
IPR027417, P-loop_NTPase
PANTHERiPTHR10763:SF23, PTHR10763:SF23, 1 hit
PfamiView protein in Pfam
PF17872, AAA_lid_10, 1 hit
PF01426, BAH, 1 hit
SMARTiView protein in SMART
SM00439, BAH, 1 hit
PROSITEiView protein in PROSITE
PS51038, BAH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIR3_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06701
Secondary accession number(s): D6VZ77, E9P924
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: May 25, 2022
This is version 191 of the entry and version 6 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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