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Protein

Complement C5

Gene

C5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled.
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processComplement alternate pathway, Complement pathway, Cytolysis, Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-MMU-166665 Terminal pathway of complement
R-MMU-174577 Activation of C3 and C5
R-MMU-375276 Peptide ligand-binding receptors
R-MMU-418594 G alpha (i) signalling events
R-MMU-977606 Regulation of Complement cascade

Protein family/group databases

MEROPSiI39.952

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C5
Alternative name(s):
Hemolytic complement
Cleaved into the following 4 chains:
Gene namesi
Name:C5
Synonyms:Hc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96031 Hc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane attack complex, Secreted

Pathology & Biotechi

Involvement in diseasei

Murine C5 deficiency is caused by a 2 base-pairs deletion resulting in frameshift and premature truncation. All C5-deficient strains contain this mutation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
ChainiPRO_000000599119 – 674Complement C5 beta chainAdd BLAST656
PropeptideiPRO_0000005992675 – 6784
ChainiPRO_0000005993679 – 1680Complement C5 alpha chainAdd BLAST1002
ChainiPRO_0000005994679 – 755C5a anaphylatoxinAdd BLAST77
ChainiPRO_0000005995756 – 1680Complement C5 alpha' chainAdd BLAST925

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi427N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi702 ↔ 728By similarity
Disulfide bondi703 ↔ 735By similarity
Disulfide bondi715 ↔ 736By similarity
Glycosylationi915N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1119N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1536 ↔ 1609By similarity
Disulfide bondi1557 ↔ 1679By similarity
Glycosylationi1633N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP06684
PaxDbiP06684
PeptideAtlasiP06684
PRIDEiP06684

PTM databases

iPTMnetiP06684
PhosphoSitePlusiP06684

Expressioni

Gene expression databases

BgeeiENSMUSG00000026874 Expressed in 71 organ(s), highest expression level in lung
CleanExiMM_HC
ExpressionAtlasiP06684 baseline and differential
GenevisibleiP06684 MM

Interactioni

Subunit structurei

C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). The C5a anaphylatoxin interacts with C5AR1.By similarity

Protein-protein interaction databases

BioGridi200226, 1 interactor
CORUMiP06684
IntActiP06684, 3 interactors
STRINGi10090.ENSMUSP00000028233

Structurei

Secondary structure

11680
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP06684
SMRiP06684
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini702 – 736Anaphylatoxin-likePROSITE-ProRule annotationAdd BLAST35
Domaini1536 – 1679NTRPROSITE-ProRule annotationAdd BLAST144

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni696 – 725Involved in C5AR1 bindingBy similarityAdd BLAST30

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1366 Eukaryota
ENOG410XRED LUCA
GeneTreeiENSGT00760000118982
HOGENOMiHOG000231860
HOVERGENiHBG098067
InParanoidiP06684
KOiK03994
OMAiYVFHYLE
OrthoDBiEOG091G00BU
PhylomeDBiP06684
TreeFamiTF313285

Family and domain databases

CDDicd00017 ANATO, 1 hit
Gene3Di2.60.40.10, 2 hits
2.60.40.690, 1 hit
InterProiView protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011626 A2M_comp
IPR002890 A2M_N
IPR011625 A2M_N_2
IPR000020 Anaphylatoxin/fibulin
IPR018081 Anaphylatoxin_comp_syst
IPR037562 Complement_C5
IPR013783 Ig-like_fold
IPR001599 Macroglobln_a2
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR008930 Terpenoid_cyclase/PrenylTrfase
IPR008993 TIMP-like_OB-fold
PANTHERiPTHR11412:SF83 PTHR11412:SF83, 1 hit
PfamiView protein in Pfam
PF00207 A2M, 1 hit
PF07678 A2M_comp, 1 hit
PF01835 A2M_N, 1 hit
PF07703 A2M_N_2, 1 hit
PF07677 A2M_recep, 1 hit
PF01821 ANATO, 1 hit
PF01759 NTR, 1 hit
SMARTiView protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit
SM00104 ANATO, 1 hit
SM00643 C345C, 1 hit
SUPFAMiSSF47686 SSF47686, 1 hit
SSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF50242 SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS01177 ANAPHYLATOXIN_1, 1 hit
PS01178 ANAPHYLATOXIN_2, 1 hit
PS50189 NTR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P06684-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLWGILCLL IFLDKTWGQE QTYVISAPKI LRVGSSENVV IQVHGYTEAF
60 70 80 90 100
DATLSLKSYP DKKVTFSSGY VNLSPENKFQ NAALLTLQPN QVPREESPVS
110 120 130 140 150
HVYLEVVSKH FSKSKKIPIT YNNGILFIHT DKPVYTPDQS VKIRVYSLGD
160 170 180 190 200
DLKPAKRETV LTFIDPEGSE VDIVEENDYT GIISFPDFKI PSNPKYGVWT
210 220 230 240 250
IKANYKKDFT TTGTAYFEIK EYVLPRFSVS IELERTFIGY KNFKNFEITV
260 270 280 290 300
KARYFYNKVV PDAEVYAFFG LREDIKDEEK QMMHKATQAA KLVDGVAQIS
310 320 330 340 350
FDSETAVKEL SYNSLEDLNN KYLYIAVTVT ESSGGFSEEA EIPGVKYVLS
360 370 380 390 400
PYTLNLVATP LFVKPGIPFS IKAQVKDSLE QAVGGVPVTL MAQTVDVNQE
410 420 430 440 450
TSDLETKRSI THDTDGVAVF VLNLPSNVTV LKFEIRTDDP ELPEENQASK
460 470 480 490 500
EYEAVAYSSL SQSYIYIAWT ENYKPMLVGE YLNIMVTPKS PYIDKITHYN
510 520 530 540 550
YLILSKGKIV QYGTREKLFS STYQNINIPV TQNMVPSARL LVYYIVTGEQ
560 570 580 590 600
TAELVADAVW INIEEKCGNQ LQVHLSPDEY VYSPGQTVSL DMVTEADSWV
610 620 630 640 650
ALSAVDRAVY KVQGNAKRAM QRVFQALDEK SDLGCGAGGG HDNADVFHLA
660 670 680 690 700
GLTFLTNANA DDSHYRDDSC KEILRSKRNL HLLRQKIEEQ AAKYKHSVPK
710 720 730 740 750
KCCYDGARVN FYETCEERVA RVTIGPLCIR AFNECCTIAN KIRKESPHKP
760 770 780 790 800
VQLGRIHIKT LLPVMKADIR SYFPESWLWE IHRVPKRKQL QVTLPDSLTT
810 820 830 840 850
WEIQGIGISD NGICVADTLK AKVFKEVFLE MNIPYSVVRG EQIQLKGTVY
860 870 880 890 900
NYMTSGTKFC VKMSAVEGIC TSGSSAASLH TSRPSRCVFQ RIEGSSSHLV
910 920 930 940 950
TFTLLPLEIG LHSINFSLET SFGKDILVKT LRVVPEGVKR ESYAGVILDP
960 970 980 990 1000
KGIRGIVNRR KEFPYRIPLD LVPKTKVERI LSVKGLLVGE FLSTVLSKEG
1010 1020 1030 1040 1050
INILTHLPKG SAEAELMSIA PVFYVFHYLE AGNHWNIFYP DTLSKRQSLE
1060 1070 1080 1090 1100
KKIKQGVVSV MSYRNADYSY SMWKGASAST WLTAFALRVL GQVAKYVKQD
1110 1120 1130 1140 1150
ENSICNSLLW LVEKCQLENG SFKENSQYLP IKLQGTLPAE AQEKTLYLTA
1160 1170 1180 1190 1200
FSVIGIRKAV DICPTMKIHT ALDKADSFLL ENTLPSKSTF TLAIVAYALS
1210 1220 1230 1240 1250
LGDRTHPRFR LIVSALRKEA FVKGDPPIYR YWRDTLKRPD SSVPSSGTAG
1260 1270 1280 1290 1300
MVETTAYALL ASLKLKDMNY ANPIIKWLSE EQRYGGGFYS TQDTINAIEG
1310 1320 1330 1340 1350
LTEYSLLLKQ IHLDMDINVA YKHEGDFHKY KVTEKHFLGR PVEVSLNDDL
1360 1370 1380 1390 1400
VVSTGYSSGL ATVYVKTVVH KISVSEEFCS FYLKIDTQDI EASSHFRLSD
1410 1420 1430 1440 1450
SGFKRIIACA SYKPSKEEST SGSSHAVMDI SLPTGIGANE EDLRALVEGV
1460 1470 1480 1490 1500
DQLLTDYQIK DGHVILQLNS IPSRDFLCVR FRIFELFQVG FLNPATFTVY
1510 1520 1530 1540 1550
EYHRPDKQCT MIYSISDTRL QKVCEGAACT CVEADCAQLQ AEVDLAISAD
1560 1570 1580 1590 1600
SRKEKACKPE TAYAYKVRIT SATEENVFVK YTATLLVTYK TGEAADENSE
1610 1620 1630 1640 1650
VTFIKKMSCT NANLVKGKQY LIMGKEVLQI KHNFSFKYIY PLDSSTWIEY
1660 1670 1680
WPTDTTCPSC QAFVENLNNF AEDLFLNSCE
Length:1,680
Mass (Da):188,878
Last modified:November 1, 1990 - v2
Checksum:i81EB5A16FAC7D95C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YUU3A0A0J9YUU3_MOUSE
Hemolytic complement
Hc
193Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35525 mRNA Translation: AAA37349.1
M35526 mRNA Translation: AAA37348.1
AL845534 Genomic DNA No translation available.
PIRiA35530 C5MS
RefSeqiNP_034536.2, NM_010406.2
UniGeneiMm.2168

Genome annotation databases

EnsembliENSMUST00000028233; ENSMUSP00000028233; ENSMUSG00000026874
GeneIDi15139
KEGGimmu:15139
UCSCiuc008jjn.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M35525 mRNA Translation: AAA37349.1
M35526 mRNA Translation: AAA37348.1
AL845534 Genomic DNA No translation available.
PIRiA35530 C5MS
RefSeqiNP_034536.2, NM_010406.2
UniGeneiMm.2168

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4P3AX-ray1.40A/B/C/D679-755[»]
4P3BX-ray2.10A/B/C/D679-754[»]
4WB2X-ray1.80A/B/C679-755[»]
4WB3X-ray2.00A/B/C679-754[»]
ProteinModelPortaliP06684
SMRiP06684
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200226, 1 interactor
CORUMiP06684
IntActiP06684, 3 interactors
STRINGi10090.ENSMUSP00000028233

Protein family/group databases

MEROPSiI39.952

PTM databases

iPTMnetiP06684
PhosphoSitePlusiP06684

Proteomic databases

MaxQBiP06684
PaxDbiP06684
PeptideAtlasiP06684
PRIDEiP06684

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028233; ENSMUSP00000028233; ENSMUSG00000026874
GeneIDi15139
KEGGimmu:15139
UCSCiuc008jjn.2 mouse

Organism-specific databases

CTDi15139
MGIiMGI:96031 Hc

Phylogenomic databases

eggNOGiKOG1366 Eukaryota
ENOG410XRED LUCA
GeneTreeiENSGT00760000118982
HOGENOMiHOG000231860
HOVERGENiHBG098067
InParanoidiP06684
KOiK03994
OMAiYVFHYLE
OrthoDBiEOG091G00BU
PhylomeDBiP06684
TreeFamiTF313285

Enzyme and pathway databases

ReactomeiR-MMU-166665 Terminal pathway of complement
R-MMU-174577 Activation of C3 and C5
R-MMU-375276 Peptide ligand-binding receptors
R-MMU-418594 G alpha (i) signalling events
R-MMU-977606 Regulation of Complement cascade

Miscellaneous databases

PROiPR:P06684
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026874 Expressed in 71 organ(s), highest expression level in lung
CleanExiMM_HC
ExpressionAtlasiP06684 baseline and differential
GenevisibleiP06684 MM

Family and domain databases

CDDicd00017 ANATO, 1 hit
Gene3Di2.60.40.10, 2 hits
2.60.40.690, 1 hit
InterProiView protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011626 A2M_comp
IPR002890 A2M_N
IPR011625 A2M_N_2
IPR000020 Anaphylatoxin/fibulin
IPR018081 Anaphylatoxin_comp_syst
IPR037562 Complement_C5
IPR013783 Ig-like_fold
IPR001599 Macroglobln_a2
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR008930 Terpenoid_cyclase/PrenylTrfase
IPR008993 TIMP-like_OB-fold
PANTHERiPTHR11412:SF83 PTHR11412:SF83, 1 hit
PfamiView protein in Pfam
PF00207 A2M, 1 hit
PF07678 A2M_comp, 1 hit
PF01835 A2M_N, 1 hit
PF07703 A2M_N_2, 1 hit
PF07677 A2M_recep, 1 hit
PF01821 ANATO, 1 hit
PF01759 NTR, 1 hit
SMARTiView protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit
SM00104 ANATO, 1 hit
SM00643 C345C, 1 hit
SUPFAMiSSF47686 SSF47686, 1 hit
SSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF50242 SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS01177 ANAPHYLATOXIN_1, 1 hit
PS01178 ANAPHYLATOXIN_2, 1 hit
PS50189 NTR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCO5_MOUSE
AccessioniPrimary (citable) accession number: P06684
Secondary accession number(s): A2AS36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: November 1, 1990
Last modified: November 7, 2018
This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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