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Protein

Complement component C9

Gene

C9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC.By similarity

GO - Biological processi

Keywordsi

Biological processComplement alternate pathway, Complement pathway, Cytolysis, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Complement component C9
Gene namesi
Name:C9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1098282 C9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei312 – 328Beta strandedSequence analysisAdd BLAST17
Transmembranei333 – 352Beta strandedSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Membrane attack complex, Secreted, Target cell membrane, Target membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000002360521 – 548Complement component C9Add BLAST528

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 76By similarity
Glycosylationi48N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi52 ↔ 55By similarity
Disulfide bondi86 ↔ 92By similarity
Disulfide bondi99 ↔ 110By similarity
Disulfide bondi105 ↔ 123By similarity
Disulfide bondi117 ↔ 132By similarity
Disulfide bondi140 ↔ 179By similarity
Glycosylationi263N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi378 ↔ 407By similarity
Glycosylationi417N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi513 ↔ 529By similarity
Disulfide bondi516 ↔ 531By similarity
Disulfide bondi533 ↔ 542By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP06683
PaxDbiP06683
PeptideAtlasiP06683
PRIDEiP06683

PTM databases

iPTMnetiP06683
PhosphoSitePlusiP06683

Expressioni

Gene expression databases

CleanExiMM_C9

Interactioni

Subunit structurei

Component of the membrane attack complex (MAC). MAC assembly is initiated by proteolytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9. About 20 C9 chains oligomerize to give rise to a huge beta-barrel that forms a 100 Angstrom diameter pore in target membranes.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022749

Structurei

3D structure databases

ProteinModelPortaliP06683
SMRiP06683
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 93TSP type-1PROSITE-ProRule annotationAdd BLAST54
Domaini97 – 134LDL-receptor class APROSITE-ProRule annotationAdd BLAST38
Domaini136 – 512MACPFPROSITE-ProRule annotationAdd BLAST377
Domaini513 – 543EGF-likeAdd BLAST31

Sequence similaritiesi

Belongs to the complement C6/C7/C8/C9 family.Curated

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiENOG410IH3C Eukaryota
ENOG410XT9A LUCA
HOGENOMiHOG000111869
HOVERGENiHBG106792
InParanoidiP06683
KOiK04000
PhylomeDBiP06683
TreeFamiTF330498

Family and domain databases

CDDicd00112 LDLa, 1 hit
Gene3Di2.20.100.10, 1 hit
InterProiView protein in InterPro
IPR037567 Complement_C9
IPR009030 Growth_fac_rcpt_cys_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR001862 MAC_perforin
IPR020864 MACPF
IPR020863 MACPF_CS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
PANTHERiPTHR19325:SF362 PTHR19325:SF362, 1 hit
PfamiView protein in Pfam
PF00057 Ldl_recept_a, 1 hit
PF01823 MACPF, 1 hit
PF00090 TSP_1, 1 hit
PRINTSiPR00764 COMPLEMENTC9
SMARTiView protein in SMART
SM00192 LDLa, 1 hit
SM00457 MACPF, 1 hit
SM00209 TSP1, 1 hit
SUPFAMiSSF57184 SSF57184, 2 hits
SSF57424 SSF57424, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 1 hit
PS00279 MACPF_1, 1 hit
PS51412 MACPF_2, 1 hit
PS50092 TSP1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGMAITLA LAIFALGVNA QMPIPVSREE QEQHYPIPID CRMSPWSNWS
60 70 80 90 100
ECDPCLKQRF RSRSILAFGQ FNGKSCVDVL GDRQGCEPTQ ECEEIQENCG
110 120 130 140 150
NDFQCETGRC IKRRLLCNGD NDCGDYSDEN DCDDDPRTPC RDRVAEESEL
160 170 180 190 200
GLTAGYGINI LGMEPLRTPF DNEFYNGLCD RVRDEKTYYR KPWNVVSLIY
210 220 230 240 250
ETKADKSFRT ENYDEHLEVF KAINREKTSN FNADFALKFS ATEVPEKGAG
260 270 280 290 300
EVSPAEHSSK PTNISAKFKF SYFMGKNFRR LSSYFSQSKK MFVHLRGVVQ
310 320 330 340 350
LGRFVMRNRD VVLRSTFLDD VKALPTSYEK GEYFGFLETY GTHYSTSGSL
360 370 380 390 400
GGQYEIVYVL DKASMKEKGV DLNDVKHCLG FNMDLRIPLQ DDLKDASVTA
410 420 430 440 450
SVNADGCIKT DNGKTVNITR DNIIDDVISF IRGGTREQAI LLKEKILRGD
460 470 480 490 500
KTFDKTDFAN WASSLANAPA LISQRMSPIY NLIPLKIKDA YIKKQNLEKA
510 520 530 540
VEDYIDEFST KRCYPCLNGG TIILLDGQCL CSCPMMFRGM ACEIHQKI
Length:548
Mass (Da):62,002
Last modified:January 23, 2002 - v2
Checksum:i8F1D16184E4781BE
GO

Sequence cautioni

The sequence AAH11137 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti88P → T in CAA29038 (PubMed:2443347).Curated1
Sequence conflicti153T → R in CAA29038 (PubMed:2443347).Curated1
Sequence conflicti241A → P in CAA29038 (PubMed:2443347).Curated1
Sequence conflicti246E → Q in CAA29038 (PubMed:2443347).Curated1
Sequence conflicti261P → A in CAA29038 (PubMed:2443347).Curated1
Sequence conflicti269 – 270KF → TI in CAA29038 (PubMed:2443347).Curated2
Sequence conflicti285F → L in CAA29038 (PubMed:2443347).Curated1
Sequence conflicti547K → T in CAA29038 (PubMed:2443347).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC011137 mRNA Translation: AAH11137.1 Different initiation.
X05475 mRNA Translation: CAA29038.1
PIRiA29677
RefSeqiNP_038513.1, NM_013485.1
UniGeneiMm.29095

Genome annotation databases

GeneIDi12279
KEGGimmu:12279
UCSCiuc007vdh.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCO9_MOUSE
AccessioniPrimary (citable) accession number: P06683
Secondary accession number(s): Q91XA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2002
Last modified: June 20, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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