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UniProtKB - P06681 (CO2_HUMAN)

Entry version 224 (07 Apr 2021)
Sequence version 2 (15 Dec 1998)
Previous versions | rss
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Protein

Complement C2

Gene

C2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.

Miscellaneous

C2 is a major histocompatibility complex class-III protein.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Selective cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to form C5a and C5b. EC:3.4.21.43

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi262Divalent metal cation1
Metal bindingi264Divalent metal cation1
Metal bindingi337Divalent metal cation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei507Charge relay system1 Publication1
Active sitei561Charge relay system1 Publication1
Active sitei679Charge relay system1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processComplement pathway, Immunity, Innate immunity
LigandMetal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P06681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-166663, Initial triggering of complement
R-HSA-174577, Activation of C3 and C5
R-HSA-977606, Regulation of Complement cascade

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P06681

Protein family/group databases

MEROPS protease database

More...MEROPSi		S01.194

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Complement C2 (EC:3.4.21.43)
Alternative name(s):
C3/C5 convertase
Cleaved into the following 2 chains:
Complement C2b fragment
Complement C2a fragment
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:1248, C2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613927, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P06681

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000166278.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Macular degeneration, age-related, 14 (ARMD14)1 Publication
Disease susceptibility may be associated with variants affecting the gene represented in this entry. Haplotype analyses have identified a statistically significant common risk haplotype and two protective haplotypes. CFB variant His-9 and C2 variant Asp-318, as well as CFB variant Gln-32 and a variant in intron 10 of C2, confer a significantly reduced risk of AMD.1 Publication
Disease descriptionA form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.
Related information in OMIM
Complement component 2 deficiency (C2D)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA rare defect of the complement classical pathway associated with the development of autoimmune disorders, mainly systemic lupus erythematosus. Skin and joint manifestations are common and renal disease is relatively rare. Patients with complement component 2 deficiency are also reported to have recurrent invasive infections.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_008544131C → Y in C2D. 1 PublicationCorresponds to variant dbSNP:rs760744400Ensembl.1
Natural variantiVAR_008545209S → F in C2D. 1 PublicationCorresponds to variant dbSNP:rs28934590Ensembl.1
Natural variantiVAR_008546464G → R in C2D. 1 PublicationCorresponds to variant dbSNP:rs151340617Ensembl.1

Keywords - Diseasei

Age-related macular degeneration, Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		717

MalaCards human disease database

More...MalaCardsi		C2
MIMi217000, phenotype
615489, phenotype

Open Targets

More...OpenTargetsi		ENSG00000166278

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		169147, Immunodeficiency due to a classical component pathway complement deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25637

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P06681, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4295701

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		C2

Domain mapping of disease mutations (DMDM)

More...DMDMi		3915642

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 202 PublicationsAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002761021 – 752Complement C2Add BLAST732
ChainiPRO_000002761121 – 243Complement C2b fragmentAdd BLAST223
ChainiPRO_0000027612244 – 752Complement C2a fragmentAdd BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi24 ↔ 64
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi51 ↔ 84
Disulfide bondi89 ↔ 131
Glycosylationi112N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi117 ↔ 144
Disulfide bondi151 ↔ 191
Disulfide bondi177 ↔ 204
Glycosylationi290N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi333N-linked (GlcNAc...) asparagine3 Publications1
Glycosylationi467N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi471N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi492 ↔ 508By similarity
Glycosylationi621N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi651N-linked (GlcNAc...) (complex) asparagine1 Publication1
Disulfide bondi675 ↔ 705By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		non-CPTAC-1104

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P06681

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P06681

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P06681

PeptideAtlas

More...PeptideAtlasi		P06681

PRoteomics IDEntifications database

More...PRIDEi		P06681

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		20143
51908 [P06681-1]
51909 [P06681-2]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1145, 17 N-Linked glycans (6 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P06681, 9 sites, 4 N-linked glycans (3 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P06681

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P06681

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000166278, Expressed in right lobe of liver and 119 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P06681, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P06681, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000166278, Tissue enriched (liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

C2a interacts with Schistosoma haematobium TOR (via N-terminal extracellular domain). This results in inhibition of the classical and lectin pathway of complement activation, probably due to interference with binding of C2a to C4b such that C3 convertase cannot be formed. This infers resistance to complement-mediated cell lysis, allowing parasite survival and infection.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107178, 12 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-5675, Classical and lectin pathway C3 convertase complex C4b2a-A
CPX-6156, Classical and lectin pathway C3 convertase complex C4b2a-B

Protein interaction database and analysis system

More...IntActi		P06681, 11 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000299367

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P06681

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P06681, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1752
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P06681

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P06681

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 86Sushi 1PROSITE-ProRule annotationAdd BLAST65
Domaini87 – 146Sushi 2PROSITE-ProRule annotationAdd BLAST60
Domaini149 – 206Sushi 3PROSITE-ProRule annotationAdd BLAST58
Domaini254 – 452VWFAPROSITE-ProRule annotationAdd BLAST199
Domaini464 – 744Peptidase S1PROSITE-ProRule annotationAdd BLAST281

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi260 – 264MIDAS-like motif5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The MIDAS-like motif in the VWFA domain binds divalent metal cations.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3627, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162934

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_022004_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P06681

Identification of Orthologs from Complete Genome Data

More...OMAi		WPRDQWF

Database for complete collections of gene phylogenies

More...PhylomeDBi		P06681

TreeFam database of animal gene trees

More...TreeFami		TF330194

Family and domain databases

Conserved Domains Database

More...CDDi		cd00033, CCP, 3 hits
cd00190, Tryp_SPc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.10.10, 2 hits
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011360, Compl_C2_B
IPR037568, Complement_C2
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001314, Peptidase_S1A
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
IPR001254, Trypsin_dom
IPR018114, TRYPSIN_HIS
IPR033116, TRYPSIN_SER
IPR002035, VWF_A
IPR036465, vWFA_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR46393, PTHR46393, 1 hit
PTHR46393:SF2, PTHR46393:SF2, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00084, Sushi, 2 hits
PF00089, Trypsin, 1 hit
PF00092, VWA, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF001154, Compl_C2_B, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00722, CHYMOTRYPSIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00032, CCP, 3 hits
SM00020, Tryp_SPc, 1 hit
SM00327, VWA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50494, SSF50494, 1 hit
SSF53300, SSF53300, 1 hit
SSF57535, SSF57535, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50923, SUSHI, 3 hits
PS50240, TRYPSIN_DOM, 1 hit
PS00134, TRYPSIN_HIS, 1 hit
PS00135, TRYPSIN_SER, 1 hit
PS50234, VWFA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 18 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P06681-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGPLMVLFCL LFLYPGLADS APSCPQNVNI SGGTFTLSHG WAPGSLLTYS 
        60         70         80         90        100
CPQGLYPSPA SRLCKSSGQW QTPGATRSLS KAVCKPVRCP APVSFENGIY 
       110        120        130        140        150
TPRLGSYPVG GNVSFECEDG FILRGSPVRQ CRPNGMWDGE TAVCDNGAGH 
       160        170        180        190        200
CPNPGISLGA VRTGFRFGHG DKVRYRCSSN LVLTGSSERE CQGNGVWSGT 
       210        220        230        240        250
EPICRQPYSY DFPEDVAPAL GTSFSHMLGA TNPTQKTKES LGRKIQIQRS 
       260        270        280        290        300
GHLNLYLLLD CSQSVSENDF LIFKESASLM VDRIFSFEIN VSVAIITFAS 
       310        320        330        340        350
EPKVLMSVLN DNSRDMTEVI SSLENANYKD HENGTGTNTY AALNSVYLMM 
       360        370        380        390        400
NNQMRLLGME TMAWQEIRHA IILLTDGKSN MGGSPKTAVD HIREILNINQ 
       410        420        430        440        450
KRNDYLDIYA IGVGKLDVDW RELNELGSKK DGERHAFILQ DTKALHQVFE 
       460        470        480        490        500
HMLDVSKLTD TICGVGNMSA NASDQERTPW HVTIKPKSQE TCRGALISDQ 
       510        520        530        540        550
WVLTAAHCFR DGNDHSLWRV NVGDPKSQWG KEFLIEKAVI SPGFDVFAKK 
       560        570        580        590        600
NQGILEFYGD DIALLKLAQK VKMSTHARPI CLPCTMEANL ALRRPQGSTC 
       610        620        630        640        650
RDHENELLNK QSVPAHFVAL NGSKLNINLK MGVEWTSCAE VVSQEKTMFP 
       660        670        680        690        700
NLTDVREVVT DQFLCSGTQE DESPCKGESG GAVFLERRFR FFQVGLVSWG 
       710        720        730        740        750
LYNPCLGSAD KNSRKRAPRS KVPPPRDFHI NLFRMQPWLR QHLGDVLNFL 

PL
Length:752
Mass (Da):83,268
Last modified:December 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5A96A13E700CF444
GO
Isoform 2 (identifier: P06681-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-147: MGPLMVLFCL...DGETAVCDNG → MRALCIRETCSSELGFSRNWSRRK
     238-328: Missing.

Show »
Length:538
Mass (Da):60,318
Checksum:iDAD9613AAAF483E8
GO
Isoform 3 (identifier: P06681-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-147: Missing.

Show »
Length:620
Mass (Da):69,444
Checksum:iFC295E99940BE04D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 18 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y3H6H0Y3H6_HUMAN
C3/C5 convertase
C2
526Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JIE7A0A0G2JIE7_HUMAN
C3/C5 convertase
C2
525Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JL69A0A0G2JL69_HUMAN
C3/C5 convertase
C2
723Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8N6L6Q8N6L6_HUMAN
C3/C5 convertase
C2
328Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z3N2F2Z3N2_HUMAN
C3/C5 convertase
C2
203Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JK28A0A0G2JK28_HUMAN
C3/C5 convertase
C2
353Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2ABG0A2ABG0_HUMAN
C3/C5 convertase
C2
158Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JYQ5C9JYQ5_HUMAN
C3/C5 convertase
C2
136Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5ST52Q5ST52_HUMAN
C3/C5 convertase
C2
139Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WCJ9F8WCJ9_HUMAN
C3/C5 convertase
C2
104Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti30I → L AA sequence (PubMed:6922702).Curated1
Sequence conflicti34T → S AA sequence (PubMed:6922702).Curated1
Sequence conflicti211D → G in BAG62532 (PubMed:14702039).Curated1
Sequence conflicti249R → S AA sequence (PubMed:6922702).Curated1
Sequence conflicti253L → K AA sequence (PubMed:6922702).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_008544131C → Y in C2D. 1 PublicationCorresponds to variant dbSNP:rs760744400Ensembl.1
Natural variantiVAR_008545209S → F in C2D. 1 PublicationCorresponds to variant dbSNP:rs28934590Ensembl.1
Natural variantiVAR_019158318E → D May be associated with a reduced risk for age-related macular degeneration. 2 PublicationsCorresponds to variant dbSNP:rs9332739EnsemblClinVar.1
Natural variantiVAR_008546464G → R in C2D. 1 PublicationCorresponds to variant dbSNP:rs151340617Ensembl.1
Natural variantiVAR_011772533F → L. Corresponds to variant dbSNP:rs1042664Ensembl.1
Natural variantiVAR_019159734R → C1 PublicationCorresponds to variant dbSNP:rs4151648Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0430381 – 147MGPLM…VCDNG → MRALCIRETCSSELGFSRNW SRRK in isoform 2. 1 PublicationAdd BLAST147
Alternative sequenceiVSP_04610316 – 147Missing in isoform 3. 1 PublicationAdd BLAST132
Alternative sequenceiVSP_043039238 – 328Missing in isoform 2. 1 PublicationAdd BLAST91

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X04481 mRNA Translation: CAA28169.1
M26301 mRNA Translation: AAA35614.1
L09708, L09706, L09707 Genomic DNA Translation: AAB97607.1
AF019413 Genomic DNA Translation: AAB67975.1
AY349611 Genomic DNA Translation: AAQ15273.1
AK298311 mRNA Translation: BAG60565.1
AK300892 mRNA Translation: BAG62532.1
AL645922 Genomic DNA No translation available.
AL662834 Genomic DNA No translation available.
AL662849 Genomic DNA No translation available.
AL671762 Genomic DNA No translation available.
AL844853 Genomic DNA No translation available.
BX005143 Genomic DNA No translation available.
CR388219 Genomic DNA No translation available.
CR759782 Genomic DNA No translation available.
CR759784 Genomic DNA No translation available.
CR933857 Genomic DNA No translation available.
BC043484 mRNA Translation: AAH43484.1
M15549 Genomic DNA Translation: AAA59649.1
M15082 Genomic DNA Translation: AAA59624.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4728.1 [P06681-1]
CCDS54991.1 [P06681-3]
CCDS56416.1 [P06681-2]

Protein sequence database of the Protein Information Resource

More...PIRi		A25971, C2HU

NCBI Reference Sequences

More...RefSeqi		NP_000054.2, NM_000063.5 [P06681-1]
NP_001139375.1, NM_001145903.2 [P06681-3]
NP_001171534.1, NM_001178063.2 [P06681-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000299367; ENSP00000299367; ENSG00000166278 [P06681-1]
ENST00000375510; ENSP00000364660; ENSG00000204364 [P06681-1]
ENST00000383362; ENSP00000372853; ENSG00000206372 [P06681-1]
ENST00000411803; ENSP00000402278; ENSG00000235696 [P06681-1]
ENST00000413548; ENSP00000407961; ENSG00000231543 [P06681-1]
ENST00000416252; ENSP00000405800; ENSG00000235017 [P06681-1]
ENST00000442278; ENSP00000395683; ENSG00000166278 [P06681-3]
ENST00000448206; ENSP00000392835; ENSG00000226560 [P06681-1]
ENST00000452323; ENSP00000392322; ENSG00000166278 [P06681-2]
ENST00000548973; ENSP00000446728; ENSG00000206372 [P06681-3]
ENST00000548995; ENSP00000449286; ENSG00000204364 [P06681-3]
ENST00000549972; ENSP00000447632; ENSG00000235696 [P06681-3]
ENST00000550682; ENSP00000446639; ENSG00000231543 [P06681-3]
ENST00000551081; ENSP00000450387; ENSG00000235017 [P06681-3]
ENST00000551648; ENSP00000449715; ENSG00000226560 [P06681-3]
ENST00000612228; ENSP00000482616; ENSG00000231543 [P06681-2]
ENST00000615380; ENSP00000481651; ENSG00000226560 [P06681-2]
ENST00000618254; ENSP00000483231; ENSG00000235017 [P06681-2]
ENST00000621558; ENSP00000480739; ENSG00000206372 [P06681-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		717

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:717

UCSC genome browser

More...UCSCi		uc010jtk.5, human [P06681-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

C2base

C2 mutation db

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04481 mRNA Translation: CAA28169.1
M26301 mRNA Translation: AAA35614.1
L09708, L09706, L09707 Genomic DNA Translation: AAB97607.1
AF019413 Genomic DNA Translation: AAB67975.1
AY349611 Genomic DNA Translation: AAQ15273.1
AK298311 mRNA Translation: BAG60565.1
AK300892 mRNA Translation: BAG62532.1
AL645922 Genomic DNA No translation available.
AL662834 Genomic DNA No translation available.
AL662849 Genomic DNA No translation available.
AL671762 Genomic DNA No translation available.
AL844853 Genomic DNA No translation available.
BX005143 Genomic DNA No translation available.
CR388219 Genomic DNA No translation available.
CR759782 Genomic DNA No translation available.
CR759784 Genomic DNA No translation available.
CR933857 Genomic DNA No translation available.
BC043484 mRNA Translation: AAH43484.1
M15549 Genomic DNA Translation: AAA59649.1
M15082 Genomic DNA Translation: AAA59624.1
CCDSiCCDS4728.1 [P06681-1]
CCDS54991.1 [P06681-3]
CCDS56416.1 [P06681-2]
PIRiA25971, C2HU
RefSeqiNP_000054.2, NM_000063.5 [P06681-1]
NP_001139375.1, NM_001145903.2 [P06681-3]
NP_001171534.1, NM_001178063.2 [P06681-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2I6QX-ray2.10A244-752[»]
2I6SX-ray2.70A244-752[»]
2ODPX-ray1.90A244-752[»]
2ODQX-ray2.30A244-752[»]
3ERBX-ray1.80A21-243[»]
SMRiP06681
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107178, 12 interactors
ComplexPortaliCPX-5675, Classical and lectin pathway C3 convertase complex C4b2a-A
CPX-6156, Classical and lectin pathway C3 convertase complex C4b2a-B
IntActiP06681, 11 interactors
STRINGi9606.ENSP00000299367

Chemistry databases

BindingDBiP06681
ChEMBLiCHEMBL4295701

Protein family/group databases

MEROPSiS01.194

PTM databases

GlyConnecti1145, 17 N-Linked glycans (6 sites)
GlyGeniP06681, 9 sites, 4 N-linked glycans (3 sites)
iPTMnetiP06681
PhosphoSitePlusiP06681

Genetic variation databases

BioMutaiC2
DMDMi3915642

Proteomic databases

CPTACinon-CPTAC-1104
jPOSTiP06681
MassIVEiP06681
PaxDbiP06681
PeptideAtlasiP06681
PRIDEiP06681
ProteomicsDBi20143
51908 [P06681-1]
51909 [P06681-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		7528, 509 antibodies

Genome annotation databases

EnsembliENST00000299367; ENSP00000299367; ENSG00000166278 [P06681-1]
ENST00000375510; ENSP00000364660; ENSG00000204364 [P06681-1]
ENST00000383362; ENSP00000372853; ENSG00000206372 [P06681-1]
ENST00000411803; ENSP00000402278; ENSG00000235696 [P06681-1]
ENST00000413548; ENSP00000407961; ENSG00000231543 [P06681-1]
ENST00000416252; ENSP00000405800; ENSG00000235017 [P06681-1]
ENST00000442278; ENSP00000395683; ENSG00000166278 [P06681-3]
ENST00000448206; ENSP00000392835; ENSG00000226560 [P06681-1]
ENST00000452323; ENSP00000392322; ENSG00000166278 [P06681-2]
ENST00000548973; ENSP00000446728; ENSG00000206372 [P06681-3]
ENST00000548995; ENSP00000449286; ENSG00000204364 [P06681-3]
ENST00000549972; ENSP00000447632; ENSG00000235696 [P06681-3]
ENST00000550682; ENSP00000446639; ENSG00000231543 [P06681-3]
ENST00000551081; ENSP00000450387; ENSG00000235017 [P06681-3]
ENST00000551648; ENSP00000449715; ENSG00000226560 [P06681-3]
ENST00000612228; ENSP00000482616; ENSG00000231543 [P06681-2]
ENST00000615380; ENSP00000481651; ENSG00000226560 [P06681-2]
ENST00000618254; ENSP00000483231; ENSG00000235017 [P06681-2]
ENST00000621558; ENSP00000480739; ENSG00000206372 [P06681-2]
GeneIDi717
KEGGihsa:717
UCSCiuc010jtk.5, human [P06681-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		717
DisGeNETi717

GeneCards: human genes, protein and diseases

More...GeneCardsi		C2
HGNCiHGNC:1248, C2
HPAiENSG00000166278, Tissue enriched (liver)
MalaCardsiC2
MIMi217000, phenotype
613927, gene
615489, phenotype
neXtProtiNX_P06681
OpenTargetsiENSG00000166278
Orphaneti169147, Immunodeficiency due to a classical component pathway complement deficiency
PharmGKBiPA25637
VEuPathDBiHostDB:ENSG00000166278.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3627, Eukaryota
GeneTreeiENSGT00940000162934
HOGENOMiCLU_022004_0_0_1
InParanoidiP06681
OMAiWPRDQWF
PhylomeDBiP06681
TreeFamiTF330194

Enzyme and pathway databases

PathwayCommonsiP06681
ReactomeiR-HSA-166663, Initial triggering of complement
R-HSA-174577, Activation of C3 and C5
R-HSA-977606, Regulation of Complement cascade
SABIO-RKiP06681

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		717, 5 hits in 982 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		C2, human
EvolutionaryTraceiP06681

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Complement_component_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		717
PharosiP06681, Tbio

Protein Ontology

More...PROi		PR:P06681
RNActiP06681, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000166278, Expressed in right lobe of liver and 119 other tissues
ExpressionAtlasiP06681, baseline and differential
GenevisibleiP06681, HS

Family and domain databases

CDDicd00033, CCP, 3 hits
cd00190, Tryp_SPc, 1 hit
Gene3Di2.40.10.10, 2 hits
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR011360, Compl_C2_B
IPR037568, Complement_C2
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR001314, Peptidase_S1A
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
IPR001254, Trypsin_dom
IPR018114, TRYPSIN_HIS
IPR033116, TRYPSIN_SER
IPR002035, VWF_A
IPR036465, vWFA_dom_sf
PANTHERiPTHR46393, PTHR46393, 1 hit
PTHR46393:SF2, PTHR46393:SF2, 1 hit
PfamiView protein in Pfam
PF00084, Sushi, 2 hits
PF00089, Trypsin, 1 hit
PF00092, VWA, 1 hit
PIRSFiPIRSF001154, Compl_C2_B, 1 hit
PRINTSiPR00722, CHYMOTRYPSIN
SMARTiView protein in SMART
SM00032, CCP, 3 hits
SM00020, Tryp_SPc, 1 hit
SM00327, VWA, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF53300, SSF53300, 1 hit
SSF57535, SSF57535, 3 hits
PROSITEiView protein in PROSITE
PS50923, SUSHI, 3 hits
PS50240, TRYPSIN_DOM, 1 hit
PS00134, TRYPSIN_HIS, 1 hit
PS00135, TRYPSIN_SER, 1 hit
PS50234, VWFA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCO2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06681
Secondary accession number(s): B4DPF3
, B4DV20, E9PFN7, O19694, Q13904
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: December 15, 1998
Last modified: April 7, 2021
This is version 224 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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