UniProtKB - P06681 (CO2_HUMAN)
Complement C2
C2
Functioni
Miscellaneous
Catalytic activityi
- Selective cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to form C5a and C5b. EC:3.4.21.43
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 262 | Divalent metal cation | 1 | |
Metal bindingi | 264 | Divalent metal cation | 1 | |
Metal bindingi | 337 | Divalent metal cation | 1 | |
Active sitei | 507 | Charge relay system1 Publication | 1 | |
Active sitei | 561 | Charge relay system1 Publication | 1 | |
Active sitei | 679 | Charge relay system1 Publication | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- serine-type endopeptidase activity Source: UniProtKB-EC
GO - Biological processi
- complement activation Source: BHF-UCL
- complement activation, classical pathway Source: ProtInc
- innate immune response Source: UniProtKB-KW
- positive regulation of apoptotic cell clearance Source: BHF-UCL
- regulation of complement activation Source: Reactome
- response to nutrient Source: Ensembl
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Biological process | Complement pathway, Immunity, Innate immunity |
Ligand | Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | P06681 |
Reactomei | R-HSA-166663, Initial triggering of complement R-HSA-174577, Activation of C3 and C5 R-HSA-977606, Regulation of Complement cascade |
SABIO-RKi | P06681 |
Protein family/group databases
MEROPSi | S01.194 |
Names & Taxonomyi
Protein namesi | Recommended name: Complement C2 (EC:3.4.21.43)Alternative name(s): C3/C5 convertase Cleaved into the following 2 chains: |
Gene namesi | Name:C2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1248, C2 |
MIMi | 613927, gene |
neXtProti | NX_P06681 |
VEuPathDBi | HostDB:ENSG00000166278.14 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: ProtInc
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
Macular degeneration, age-related, 14 (ARMD14)1 Publication
Complement component 2 deficiency (C2D)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_008544 | 131 | C → Y in C2D. 1 PublicationCorresponds to variant dbSNP:rs760744400Ensembl. | 1 | |
Natural variantiVAR_008545 | 209 | S → F in C2D. 1 PublicationCorresponds to variant dbSNP:rs28934590Ensembl. | 1 | |
Natural variantiVAR_008546 | 464 | G → R in C2D. 1 PublicationCorresponds to variant dbSNP:rs151340617Ensembl. | 1 |
Keywords - Diseasei
Age-related macular degeneration, Disease variantOrganism-specific databases
DisGeNETi | 717 |
MalaCardsi | C2 |
MIMi | 217000, phenotype 615489, phenotype |
OpenTargetsi | ENSG00000166278 |
Orphaneti | 169147, Immunodeficiency due to a classical component pathway complement deficiency |
PharmGKBi | PA25637 |
Miscellaneous databases
Pharosi | P06681, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295701 |
Genetic variation databases
BioMutai | C2 |
DMDMi | 3915642 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | 2 PublicationsAdd BLAST | 20 | |
ChainiPRO_0000027610 | 21 – 752 | Complement C2Add BLAST | 732 | |
ChainiPRO_0000027611 | 21 – 243 | Complement C2b fragmentAdd BLAST | 223 | |
ChainiPRO_0000027612 | 244 – 752 | Complement C2a fragmentAdd BLAST | 509 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 24 ↔ 64 | |||
Glycosylationi | 29 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 51 ↔ 84 | |||
Disulfide bondi | 89 ↔ 131 | |||
Glycosylationi | 112 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Disulfide bondi | 117 ↔ 144 | |||
Disulfide bondi | 151 ↔ 191 | |||
Disulfide bondi | 177 ↔ 204 | |||
Glycosylationi | 290 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 333 | N-linked (GlcNAc...) asparagine3 Publications | 1 | |
Glycosylationi | 467 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 471 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 492 ↔ 508 | By similarity | ||
Glycosylationi | 621 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 651 | N-linked (GlcNAc...) (complex) asparagine1 Publication | 1 | |
Disulfide bondi | 675 ↔ 705 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
CPTACi | non-CPTAC-1104 |
jPOSTi | P06681 |
MassIVEi | P06681 |
PaxDbi | P06681 |
PeptideAtlasi | P06681 |
PRIDEi | P06681 |
ProteomicsDBi | 20143 51908 [P06681-1] 51909 [P06681-2] |
PTM databases
GlyConnecti | 1145, 17 N-Linked glycans (6 sites) |
GlyGeni | P06681, 9 sites, 4 N-linked glycans (3 sites) |
iPTMneti | P06681 |
PhosphoSitePlusi | P06681 |
Expressioni
Gene expression databases
Bgeei | ENSG00000166278, Expressed in right lobe of liver and 119 other tissues |
ExpressionAtlasi | P06681, baseline and differential |
Genevisiblei | P06681, HS |
Organism-specific databases
HPAi | ENSG00000166278, Tissue enriched (liver) |
Interactioni
Subunit structurei
C2a interacts with Schistosoma haematobium TOR (via N-terminal extracellular domain). This results in inhibition of the classical and lectin pathway of complement activation, probably due to interference with binding of C2a to C4b such that C3 convertase cannot be formed. This infers resistance to complement-mediated cell lysis, allowing parasite survival and infection.
1 PublicationBinary interactionsi
Hide detailsP06681
Protein-protein interaction databases
BioGRIDi | 107178, 12 interactors |
ComplexPortali | CPX-5675, Classical and lectin pathway C3 convertase complex C4b2a-A CPX-6156, Classical and lectin pathway C3 convertase complex C4b2a-B |
IntActi | P06681, 11 interactors |
STRINGi | 9606.ENSP00000299367 |
Chemistry databases
BindingDBi | P06681 |
Miscellaneous databases
RNActi | P06681, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P06681 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P06681 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 86 | Sushi 1PROSITE-ProRule annotationAdd BLAST | 65 | |
Domaini | 87 – 146 | Sushi 2PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 149 – 206 | Sushi 3PROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 254 – 452 | VWFAPROSITE-ProRule annotationAdd BLAST | 199 | |
Domaini | 464 – 744 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 281 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 260 – 264 | MIDAS-like motif | 5 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, SushiPhylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT00940000162934 |
HOGENOMi | CLU_022004_0_0_1 |
InParanoidi | P06681 |
OMAi | WPRDQWF |
PhylomeDBi | P06681 |
TreeFami | TF330194 |
Family and domain databases
CDDi | cd00033, CCP, 3 hits cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 3.40.50.410, 1 hit |
InterProi | View protein in InterPro IPR011360, Compl_C2_B IPR037568, Complement_C2 IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER IPR002035, VWF_A IPR036465, vWFA_dom_sf |
PANTHERi | PTHR46393, PTHR46393, 1 hit PTHR46393:SF2, PTHR46393:SF2, 1 hit |
Pfami | View protein in Pfam PF00084, Sushi, 2 hits PF00089, Trypsin, 1 hit PF00092, VWA, 1 hit |
PIRSFi | PIRSF001154, Compl_C2_B, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00032, CCP, 3 hits SM00020, Tryp_SPc, 1 hit SM00327, VWA, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF53300, SSF53300, 1 hit SSF57535, SSF57535, 3 hits |
PROSITEi | View protein in PROSITE PS50923, SUSHI, 3 hits PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit PS50234, VWFA, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 18 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGPLMVLFCL LFLYPGLADS APSCPQNVNI SGGTFTLSHG WAPGSLLTYS
60 70 80 90 100
CPQGLYPSPA SRLCKSSGQW QTPGATRSLS KAVCKPVRCP APVSFENGIY
110 120 130 140 150
TPRLGSYPVG GNVSFECEDG FILRGSPVRQ CRPNGMWDGE TAVCDNGAGH
160 170 180 190 200
CPNPGISLGA VRTGFRFGHG DKVRYRCSSN LVLTGSSERE CQGNGVWSGT
210 220 230 240 250
EPICRQPYSY DFPEDVAPAL GTSFSHMLGA TNPTQKTKES LGRKIQIQRS
260 270 280 290 300
GHLNLYLLLD CSQSVSENDF LIFKESASLM VDRIFSFEIN VSVAIITFAS
310 320 330 340 350
EPKVLMSVLN DNSRDMTEVI SSLENANYKD HENGTGTNTY AALNSVYLMM
360 370 380 390 400
NNQMRLLGME TMAWQEIRHA IILLTDGKSN MGGSPKTAVD HIREILNINQ
410 420 430 440 450
KRNDYLDIYA IGVGKLDVDW RELNELGSKK DGERHAFILQ DTKALHQVFE
460 470 480 490 500
HMLDVSKLTD TICGVGNMSA NASDQERTPW HVTIKPKSQE TCRGALISDQ
510 520 530 540 550
WVLTAAHCFR DGNDHSLWRV NVGDPKSQWG KEFLIEKAVI SPGFDVFAKK
560 570 580 590 600
NQGILEFYGD DIALLKLAQK VKMSTHARPI CLPCTMEANL ALRRPQGSTC
610 620 630 640 650
RDHENELLNK QSVPAHFVAL NGSKLNINLK MGVEWTSCAE VVSQEKTMFP
660 670 680 690 700
NLTDVREVVT DQFLCSGTQE DESPCKGESG GAVFLERRFR FFQVGLVSWG
710 720 730 740 750
LYNPCLGSAD KNSRKRAPRS KVPPPRDFHI NLFRMQPWLR QHLGDVLNFL
PL
Computationally mapped potential isoform sequencesi
There are 18 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y3H6 | H0Y3H6_HUMAN | C3/C5 convertase | C2 | 526 | Annotation score: | ||
A0A0G2JIE7 | A0A0G2JIE7_HUMAN | C3/C5 convertase | C2 | 525 | Annotation score: | ||
A0A0G2JL69 | A0A0G2JL69_HUMAN | C3/C5 convertase | C2 | 723 | Annotation score: | ||
Q8N6L6 | Q8N6L6_HUMAN | C3/C5 convertase | C2 | 328 | Annotation score: | ||
F2Z3N2 | F2Z3N2_HUMAN | C3/C5 convertase | C2 | 203 | Annotation score: | ||
A0A0G2JK28 | A0A0G2JK28_HUMAN | C3/C5 convertase | C2 | 353 | Annotation score: | ||
A2ABG0 | A2ABG0_HUMAN | C3/C5 convertase | C2 | 158 | Annotation score: | ||
C9JYQ5 | C9JYQ5_HUMAN | C3/C5 convertase | C2 | 136 | Annotation score: | ||
Q5ST52 | Q5ST52_HUMAN | C3/C5 convertase | C2 | 139 | Annotation score: | ||
F8WCJ9 | F8WCJ9_HUMAN | C3/C5 convertase | C2 | 104 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 30 | I → L AA sequence (PubMed:6922702).Curated | 1 | |
Sequence conflicti | 34 | T → S AA sequence (PubMed:6922702).Curated | 1 | |
Sequence conflicti | 211 | D → G in BAG62532 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 249 | R → S AA sequence (PubMed:6922702).Curated | 1 | |
Sequence conflicti | 253 | L → K AA sequence (PubMed:6922702).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_008544 | 131 | C → Y in C2D. 1 PublicationCorresponds to variant dbSNP:rs760744400Ensembl. | 1 | |
Natural variantiVAR_008545 | 209 | S → F in C2D. 1 PublicationCorresponds to variant dbSNP:rs28934590Ensembl. | 1 | |
Natural variantiVAR_019158 | 318 | E → D May be associated with a reduced risk for age-related macular degeneration. 2 PublicationsCorresponds to variant dbSNP:rs9332739EnsemblClinVar. | 1 | |
Natural variantiVAR_008546 | 464 | G → R in C2D. 1 PublicationCorresponds to variant dbSNP:rs151340617Ensembl. | 1 | |
Natural variantiVAR_011772 | 533 | F → L. Corresponds to variant dbSNP:rs1042664Ensembl. | 1 | |
Natural variantiVAR_019159 | 734 | R → C1 PublicationCorresponds to variant dbSNP:rs4151648Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043038 | 1 – 147 | MGPLM…VCDNG → MRALCIRETCSSELGFSRNW SRRK in isoform 2. 1 PublicationAdd BLAST | 147 | |
Alternative sequenceiVSP_046103 | 16 – 147 | Missing in isoform 3. 1 PublicationAdd BLAST | 132 | |
Alternative sequenceiVSP_043039 | 238 – 328 | Missing in isoform 2. 1 PublicationAdd BLAST | 91 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04481 mRNA Translation: CAA28169.1 M26301 mRNA Translation: AAA35614.1 L09708, L09706, L09707 Genomic DNA Translation: AAB97607.1 AF019413 Genomic DNA Translation: AAB67975.1 AY349611 Genomic DNA Translation: AAQ15273.1 AK298311 mRNA Translation: BAG60565.1 AK300892 mRNA Translation: BAG62532.1 AL645922 Genomic DNA No translation available. AL662834 Genomic DNA No translation available. AL662849 Genomic DNA No translation available. AL671762 Genomic DNA No translation available. AL844853 Genomic DNA No translation available. BX005143 Genomic DNA No translation available. CR388219 Genomic DNA No translation available. CR759782 Genomic DNA No translation available. CR759784 Genomic DNA No translation available. CR933857 Genomic DNA No translation available. BC043484 mRNA Translation: AAH43484.1 M15549 Genomic DNA Translation: AAA59649.1 M15082 Genomic DNA Translation: AAA59624.1 |
CCDSi | CCDS4728.1 [P06681-1] CCDS54991.1 [P06681-3] CCDS56416.1 [P06681-2] |
PIRi | A25971, C2HU |
RefSeqi | NP_000054.2, NM_000063.5 [P06681-1] NP_001139375.1, NM_001145903.2 [P06681-3] NP_001171534.1, NM_001178063.2 [P06681-2] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
C2base C2 mutation db |
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X04481 mRNA Translation: CAA28169.1 M26301 mRNA Translation: AAA35614.1 L09708, L09706, L09707 Genomic DNA Translation: AAB97607.1 AF019413 Genomic DNA Translation: AAB67975.1 AY349611 Genomic DNA Translation: AAQ15273.1 AK298311 mRNA Translation: BAG60565.1 AK300892 mRNA Translation: BAG62532.1 AL645922 Genomic DNA No translation available. AL662834 Genomic DNA No translation available. AL662849 Genomic DNA No translation available. AL671762 Genomic DNA No translation available. AL844853 Genomic DNA No translation available. BX005143 Genomic DNA No translation available. CR388219 Genomic DNA No translation available. CR759782 Genomic DNA No translation available. CR759784 Genomic DNA No translation available. CR933857 Genomic DNA No translation available. BC043484 mRNA Translation: AAH43484.1 M15549 Genomic DNA Translation: AAA59649.1 M15082 Genomic DNA Translation: AAA59624.1 |
CCDSi | CCDS4728.1 [P06681-1] CCDS54991.1 [P06681-3] CCDS56416.1 [P06681-2] |
PIRi | A25971, C2HU |
RefSeqi | NP_000054.2, NM_000063.5 [P06681-1] NP_001139375.1, NM_001145903.2 [P06681-3] NP_001171534.1, NM_001178063.2 [P06681-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2I6Q | X-ray | 2.10 | A | 244-752 | [»] | |
2I6S | X-ray | 2.70 | A | 244-752 | [»] | |
2ODP | X-ray | 1.90 | A | 244-752 | [»] | |
2ODQ | X-ray | 2.30 | A | 244-752 | [»] | |
3ERB | X-ray | 1.80 | A | 21-243 | [»] | |
SMRi | P06681 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107178, 12 interactors |
ComplexPortali | CPX-5675, Classical and lectin pathway C3 convertase complex C4b2a-A CPX-6156, Classical and lectin pathway C3 convertase complex C4b2a-B |
IntActi | P06681, 11 interactors |
STRINGi | 9606.ENSP00000299367 |
Chemistry databases
BindingDBi | P06681 |
ChEMBLi | CHEMBL4295701 |
Protein family/group databases
MEROPSi | S01.194 |
PTM databases
GlyConnecti | 1145, 17 N-Linked glycans (6 sites) |
GlyGeni | P06681, 9 sites, 4 N-linked glycans (3 sites) |
iPTMneti | P06681 |
PhosphoSitePlusi | P06681 |
Genetic variation databases
BioMutai | C2 |
DMDMi | 3915642 |
Proteomic databases
CPTACi | non-CPTAC-1104 |
jPOSTi | P06681 |
MassIVEi | P06681 |
PaxDbi | P06681 |
PeptideAtlasi | P06681 |
PRIDEi | P06681 |
ProteomicsDBi | 20143 51908 [P06681-1] 51909 [P06681-2] |
Protocols and materials databases
Antibodypediai | 7528, 509 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 717 |
DisGeNETi | 717 |
GeneCardsi | C2 |
HGNCi | HGNC:1248, C2 |
HPAi | ENSG00000166278, Tissue enriched (liver) |
MalaCardsi | C2 |
MIMi | 217000, phenotype 613927, gene 615489, phenotype |
neXtProti | NX_P06681 |
OpenTargetsi | ENSG00000166278 |
Orphaneti | 169147, Immunodeficiency due to a classical component pathway complement deficiency |
PharmGKBi | PA25637 |
VEuPathDBi | HostDB:ENSG00000166278.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT00940000162934 |
HOGENOMi | CLU_022004_0_0_1 |
InParanoidi | P06681 |
OMAi | WPRDQWF |
PhylomeDBi | P06681 |
TreeFami | TF330194 |
Enzyme and pathway databases
PathwayCommonsi | P06681 |
Reactomei | R-HSA-166663, Initial triggering of complement R-HSA-174577, Activation of C3 and C5 R-HSA-977606, Regulation of Complement cascade |
SABIO-RKi | P06681 |
Miscellaneous databases
BioGRID-ORCSi | 717, 5 hits in 982 CRISPR screens |
ChiTaRSi | C2, human |
EvolutionaryTracei | P06681 |
GeneWikii | Complement_component_2 |
GenomeRNAii | 717 |
Pharosi | P06681, Tbio |
PROi | PR:P06681 |
RNActi | P06681, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166278, Expressed in right lobe of liver and 119 other tissues |
ExpressionAtlasi | P06681, baseline and differential |
Genevisiblei | P06681, HS |
Family and domain databases
CDDi | cd00033, CCP, 3 hits cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 3.40.50.410, 1 hit |
InterProi | View protein in InterPro IPR011360, Compl_C2_B IPR037568, Complement_C2 IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom IPR001254, Trypsin_dom IPR018114, TRYPSIN_HIS IPR033116, TRYPSIN_SER IPR002035, VWF_A IPR036465, vWFA_dom_sf |
PANTHERi | PTHR46393, PTHR46393, 1 hit PTHR46393:SF2, PTHR46393:SF2, 1 hit |
Pfami | View protein in Pfam PF00084, Sushi, 2 hits PF00089, Trypsin, 1 hit PF00092, VWA, 1 hit |
PIRSFi | PIRSF001154, Compl_C2_B, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00032, CCP, 3 hits SM00020, Tryp_SPc, 1 hit SM00327, VWA, 1 hit |
SUPFAMi | SSF50494, SSF50494, 1 hit SSF53300, SSF53300, 1 hit SSF57535, SSF57535, 3 hits |
PROSITEi | View protein in PROSITE PS50923, SUSHI, 3 hits PS50240, TRYPSIN_DOM, 1 hit PS00134, TRYPSIN_HIS, 1 hit PS00135, TRYPSIN_SER, 1 hit PS50234, VWFA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CO2_HUMAN | |
Accessioni | P06681Primary (citable) accession number: P06681 Secondary accession number(s): B4DPF3 Q13904 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | December 15, 1998 | |
Last modified: | April 7, 2021 | |
This is version 224 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families