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UniProtKB - P06622 (XYLE1_PSEPU)
Protein
Metapyrocatechase
Gene
xylE
Organism
Pseudomonas putida (Arthrobacter siderocapsulatus)
Status
Functioni
Catalytic activityi
- EC:1.13.11.2
Cofactori
: toluene degradation Pathwayi
This protein is involved in the pathway toluene degradation, which is part of Xenobiotic degradation.View all proteins of this organism that are known to be involved in the pathway toluene degradation and in Xenobiotic degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 153 | Iron | 1 | |
Metal bindingi | 214 | Iron | 1 | |
Metal bindingi | 265 | Iron | 1 |
GO - Molecular functioni
- catechol 2,3-dioxygenase activity Source: UniProtKB-EC
- ferrous iron binding Source: InterPro
GO - Biological processi
- toluene catabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Dioxygenase, Oxidoreductase |
Biological process | Aromatic hydrocarbons catabolism |
Ligand | Iron, Metal-binding |
Enzyme and pathway databases
BRENDAi | 1.13.11.2, 5092 |
UniPathwayi | UPA00273 |
Names & Taxonomyi
Protein namesi | Recommended name: Metapyrocatechase (EC:1.13.11.2)Short name: MPC Alternative name(s): CatO2ase Catechol 2,3-dioxygenase |
Gene namesi | Name:xylE |
Encoded oni | Plasmid TOL pWW0 |
Organismi | Pseudomonas putida (Arthrobacter siderocapsulatus) |
Taxonomic identifieri | 303 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085027 | 1 – 307 | MetapyrocatechaseAdd BLAST | 307 |
Interactioni
Subunit structurei
Homotetramer.
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P06622 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P06622 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 122 | VOC 1PROSITE-ProRule annotationAdd BLAST | 116 | |
Domaini | 150 – 269 | VOC 2PROSITE-ProRule annotationAdd BLAST | 120 |
Sequence similaritiesi
Belongs to the extradiol ring-cleavage dioxygenase family.Curated
Keywords - Domaini
RepeatFamily and domain databases
Gene3Di | 3.10.180.10, 2 hits |
InterProi | View protein in InterPro IPR017624, Catechol_2-3_dOase IPR029068, Glyas_Bleomycin-R_OHBP_Dase IPR004360, Glyas_Fos-R_dOase_dom IPR037523, VOC IPR000486, Xdiol_ring_cleave_dOase_1/2 |
Pfami | View protein in Pfam PF00903, Glyoxalase, 2 hits |
SUPFAMi | SSF54593, SSF54593, 1 hit |
TIGRFAMsi | TIGR03211, catechol_2_3, 1 hit |
PROSITEi | View protein in PROSITE PS00082, EXTRADIOL_DIOXYGENAS, 1 hit PS51819, VOC, 2 hits |
i Sequence
Sequence statusi: Complete.
P06622-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNKGVMRPGH VQLRVLDMSK ALEHYVELLG LIEMDRDDQG RVYLKAWTEV
60 70 80 90 100
DKFSLVLREA DEPGMDFMGF KVVDEDALRQ LERDLMAYGC AVEQLPAGEL
110 120 130 140 150
NSCGRRVRFQ APSGHHFELY ADKEYTGKWG LNDVNPEAWP RDLKGMAAVR
160 170 180 190 200
FDHALMYGDE LPATYDLFTK VLGFYLAEQV LDENGTRVAQ FLSLSTKAHD
210 220 230 240 250
VAFIHHPEKG RLHHVSFHLE TWEDLLRAAD LISMTDTSID IGPTRHGLTH
260 270 280 290 300
GKTIYFFDPS GNRNEVFCGG DYNYPDHKPV TWTTDQLGKA IFYHDRILNE
RFMTVLT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V01161 Genomic DNA Translation: CAA24490.1 M64747 Genomic DNA Translation: AAA26052.1 |
PIRi | A20852 |
RefSeqi | NP_542866.1, NC_003350.1 WP_011005909.1, NZ_QWEF01000005.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V01161 Genomic DNA Translation: CAA24490.1 M64747 Genomic DNA Translation: AAA26052.1 |
PIRi | A20852 |
RefSeqi | NP_542866.1, NC_003350.1 WP_011005909.1, NZ_QWEF01000005.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1MPY | X-ray | 2.80 | A/B/C/D | 1-307 | [»] | |
SMRi | P06622 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Enzyme and pathway databases
UniPathwayi | UPA00273 |
BRENDAi | 1.13.11.2, 5092 |
Miscellaneous databases
EvolutionaryTracei | P06622 |
Family and domain databases
Gene3Di | 3.10.180.10, 2 hits |
InterProi | View protein in InterPro IPR017624, Catechol_2-3_dOase IPR029068, Glyas_Bleomycin-R_OHBP_Dase IPR004360, Glyas_Fos-R_dOase_dom IPR037523, VOC IPR000486, Xdiol_ring_cleave_dOase_1/2 |
Pfami | View protein in Pfam PF00903, Glyoxalase, 2 hits |
SUPFAMi | SSF54593, SSF54593, 1 hit |
TIGRFAMsi | TIGR03211, catechol_2_3, 1 hit |
PROSITEi | View protein in PROSITE PS00082, EXTRADIOL_DIOXYGENAS, 1 hit PS51819, VOC, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | XYLE1_PSEPU | |
Accessioni | P06622Primary (citable) accession number: P06622 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | January 1, 1988 | |
Last modified: | February 23, 2022 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, PlasmidDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families