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Protein

HTH-type transcriptional regulator CysB

Gene

cysB

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is a positive regulator of gene expression for the cysteine regulon, a system of 10 or more loci involved in the biosynthesis of L-cysteine from inorganic sulfate. The inducer for CysB is N-acetylserine. CysB inhibits its own transcription.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi19 – 38H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processAmino-acid biosynthesis, Cysteine biosynthesis, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciSENT99287:G1FZD-1730-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator CysB
Alternative name(s):
Cys regulon transcriptional activator
Gene namesi
Name:cysB
Ordered Locus Names:STM1713
OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Taxonomic identifieri99287 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
Proteomesi
  • UP000001014 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001056161 – 324HTH-type transcriptional regulator CysBAdd BLAST324

Proteomic databases

PaxDbiP06614
PRIDEiP06614

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi99287.STM1713

Structurei

Secondary structure

1324
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi93 – 99Combined sources7
Helixi101 – 106Combined sources6
Helixi109 – 118Combined sources10
Beta strandi122 – 128Combined sources7
Helixi131 – 139Combined sources9
Beta strandi144 – 149Combined sources6
Helixi152 – 154Combined sources3
Beta strandi158 – 166Combined sources9
Beta strandi168 – 172Combined sources5
Helixi177 – 180Combined sources4
Helixi186 – 189Combined sources4
Beta strandi192 – 197Combined sources6
Beta strandi201 – 203Combined sources3
Helixi204 – 213Combined sources10
Beta strandi219 – 225Combined sources7
Helixi227 – 234Combined sources8
Turni235 – 237Combined sources3
Beta strandi240 – 244Combined sources5
Helixi245 – 247Combined sources3
Turni250 – 252Combined sources3
Beta strandi257 – 260Combined sources4
Turni262 – 264Combined sources3
Beta strandi268 – 274Combined sources7
Beta strandi276 – 278Combined sources3
Helixi282 – 291Combined sources10
Helixi297 – 306Combined sources10
Helixi309 – 315Combined sources7
Turni316 – 318Combined sources3

3D structure databases

ProteinModelPortaliP06614
SMRiP06614
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 59HTH lysR-typePROSITE-ProRule annotationAdd BLAST59

Phylogenomic databases

eggNOGiENOG4107R11 Bacteria
ENOG410XP61 LUCA
HOGENOMiHOG000260068
KOiK13634
OMAiKDGYGMQ
PhylomeDBiP06614

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR005119 LysR_subst-bd
IPR000847 Tscrpt_reg_HTH_LysR
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00126 HTH_1, 1 hit
PF03466 LysR_substrate, 1 hit
PRINTSiPR00039 HTHLYSR
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS50931 HTH_LYSR, 1 hit

Sequencei

Sequence statusi: Complete.

P06614-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLQQLRYIV EVVNHNLNVS STAEGLYTSQ PGISKQVRML EDELGIQIFA
60 70 80 90 100
RSGKHLTQVT PAGQEIIRIA REVLSKVDAI KSVAGEHTWP DKGSLYIATT
110 120 130 140 150
HTQARYALPG VIKGFIERYP RVSLHMHQGS PTQIAEAVSK GNADFAIATE
160 170 180 190 200
ALHLYDDLVM LPCYHWNRSI VVTPDHPLAA TSSVTIEALA QYPLVTYTFG
210 220 230 240 250
FTGRSELDTA FNRAGLTPRI VFTATDADVI KTYVRLGLGV GVIASMAVDP
260 270 280 290 300
LADPDLVRID AHDIFSHSTT KIGFRRSTFL RSYMYDFIQR FAPHLTRDVV
310 320
DTAVALRSNE EIEAMFQDIK LPEK
Length:324
Mass (Da):36,013
Last modified:January 1, 1988 - v1
Checksum:iCCECF585A6851D34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15040 Genomic DNA Translation: AAA27045.1
AE006468 Genomic DNA Translation: AAL20631.1
PIRiB26695 RGEBCB
RefSeqiNP_460672.1, NC_003197.2
WP_000776233.1, NC_003197.2

Genome annotation databases

EnsemblBacteriaiAAL20631; AAL20631; STM1713
GeneIDi1253232
KEGGistm:STM1713
PATRICifig|99287.12.peg.1810

Similar proteinsi

Entry informationi

Entry nameiCYSB_SALTY
AccessioniPrimary (citable) accession number: P06614
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: February 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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