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Entry version 164 (31 Jul 2019)
Sequence version 3 (01 Nov 1997)
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Protein

Vitamin B12 import system permease protein BtuC

Gene

btuC

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:BTUC-MONOMER
ECOL316407:JW1701-MONOMER
MetaCyc:BTUC-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.3.33 2026

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.13.1 the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vitamin B12 import system permease protein BtuC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:btuC
Ordered Locus Names:b1711, JW1701
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...
EcoGenei
EG10127 btuC

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 10Cytoplasmic1 Publication10
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei11 – 35Helical; Name=1Add BLAST25
Topological domaini36 – 56Periplasmic1 PublicationAdd BLAST21
Transmembranei57 – 81Helical; Name=2Add BLAST25
Topological domaini82 – 92Cytoplasmic1 PublicationAdd BLAST11
Transmembranei93 – 107Helical; Name=3Add BLAST15
Topological domaini108 – 113Periplasmic1 Publication6
Transmembranei114 – 138Helical; Name=4Add BLAST25
Topological domaini139 – 141Cytoplasmic1 Publication3
Transmembranei142 – 166Helical; Name=5Add BLAST25
Topological domaini167 – 190Periplasmic1 PublicationAdd BLAST24
Transmembranei191 – 206Helical; Name=6Add BLAST16
Topological domaini207 – 228Cytoplasmic1 PublicationAdd BLAST22
Transmembranei229 – 249Helical; Name=7Add BLAST21
Topological domaini250 – 257Periplasmic1 Publication8
Transmembranei258 – 267Helical; Name=810
Topological domaini268 – 274Cytoplasmic1 Publication7
Transmembranei275 – 296Helical; Name=9Add BLAST22
Topological domaini297 – 304Periplasmic1 Publication8
Transmembranei305 – 324Helical; Name=10Add BLAST20
Topological domaini325 – 326Cytoplasmic1 Publication2

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000599681 – 326Vitamin B12 import system permease protein BtuCAdd BLAST326

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P06609

PRoteomics IDEntifications database

More...
PRIDEi
P06609

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The complex is composed of two ATP-binding proteins (BtuD), two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4263152, 131 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-2105 Cobalamin transport complex
CPX-2106 BtuCD complex

Database of interacting proteins

More...
DIPi
DIP-9233N

Protein interaction database and analysis system

More...
IntActi
P06609, 2 interactors

Molecular INTeraction database

More...
MINTi
P06609

STRING: functional protein association networks

More...
STRINGi
511145.b1711

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1326
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P06609

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P06609

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108ESU Bacteria
COG4139 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000045407

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P06609

KEGG Orthology (KO)

More...
KOi
K06073

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P06609

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3470.10, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01004 BtuC, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037294 ABC_BtuC-like
IPR023691 ABC_transptr_BtuC
IPR000522 ABC_transptr_permease_BtuC

The PANTHER Classification System

More...
PANTHERi
PTHR30472 PTHR30472, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01032 FecCD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81345 SSF81345, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P06609-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTLARQQQR QNIRWLLCLS VLMLLALLLS LCAGEQWISP GDWFTPRGEL
60 70 80 90 100
FVWQIRLPRT LAVLLVGAAL AISGAVMQAL FENPLAEPGL LGVSNGAGVG
110 120 130 140 150
LIAAVLLGQG QLPNWALGLC AIAGALIITL ILLRFARRHL STSRLLLAGV
160 170 180 190 200
ALGIICSALM TWAIYFSTSV DLRQLMYWMM GGFGGVDWRQ SWLMLALIPV
210 220 230 240 250
LLWICCQSRP MNMLALGEIS ARQLGLPLWF WRNVLVAATG WMVGVSVALA
260 270 280 290 300
GAIGFIGLVI PHILRLCGLT DHRVLLPGCA LAGASALLLA DIVARLALAA
310 320
AELPIGVVTA TLGAPVFIWL LLKAGR
Length:326
Mass (Da):34,949
Last modified:November 1, 1997 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC65882B1C47BFE69
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti111 – 112QL → LT in AAA23526 (PubMed:3528129).Curated2
Sequence conflicti123A → R in AAA23526 (PubMed:3528129).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M14031 Genomic DNA Translation: AAA23526.1
U00096 Genomic DNA Translation: AAC74781.1
AP009048 Genomic DNA Translation: BAA15479.1

Protein sequence database of the Protein Information Resource

More...
PIRi
G64929 QRECBC

NCBI Reference Sequences

More...
RefSeqi
NP_416226.1, NC_000913.3
WP_000956528.1, NZ_SSZK01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC74781; AAC74781; b1711
BAA15479; BAA15479; BAA15479

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
945877

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW1701
eco:b1711

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.546

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14031 Genomic DNA Translation: AAA23526.1
U00096 Genomic DNA Translation: AAC74781.1
AP009048 Genomic DNA Translation: BAA15479.1
PIRiG64929 QRECBC
RefSeqiNP_416226.1, NC_000913.3
WP_000956528.1, NZ_SSZK01000001.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1L7VX-ray3.20A/B1-326[»]
2QI9X-ray2.60A/B1-326[»]
4DBLX-ray3.49A/B/F/G1-326[»]
4FI3X-ray3.47A/B1-326[»]
4R9UX-ray2.78A/B1-326[»]
SMRiP06609
ModBaseiSearch...

Protein-protein interaction databases

BioGridi4263152, 131 interactors
ComplexPortaliCPX-2105 Cobalamin transport complex
CPX-2106 BtuCD complex
DIPiDIP-9233N
IntActiP06609, 2 interactors
MINTiP06609
STRINGi511145.b1711

Protein family/group databases

TCDBi3.A.1.13.1 the atp-binding cassette (abc) superfamily

Proteomic databases

PaxDbiP06609
PRIDEiP06609

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74781; AAC74781; b1711
BAA15479; BAA15479; BAA15479
GeneIDi945877
KEGGiecj:JW1701
eco:b1711
PATRICifig|1411691.4.peg.546

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB0125
EcoGeneiEG10127 btuC

Phylogenomic databases

eggNOGiENOG4108ESU Bacteria
COG4139 LUCA
HOGENOMiHOG000045407
InParanoidiP06609
KOiK06073
PhylomeDBiP06609

Enzyme and pathway databases

BioCyciEcoCyc:BTUC-MONOMER
ECOL316407:JW1701-MONOMER
MetaCyc:BTUC-MONOMER
BRENDAi3.6.3.33 2026

Miscellaneous databases

EvolutionaryTraceiP06609

Protein Ontology

More...
PROi
PR:P06609

Family and domain databases

Gene3Di1.10.3470.10, 1 hit
HAMAPiMF_01004 BtuC, 1 hit
InterProiView protein in InterPro
IPR037294 ABC_BtuC-like
IPR023691 ABC_transptr_BtuC
IPR000522 ABC_transptr_permease_BtuC
PANTHERiPTHR30472 PTHR30472, 1 hit
PfamiView protein in Pfam
PF01032 FecCD, 1 hit
SUPFAMiSSF81345 SSF81345, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBTUC_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06609
Secondary accession number(s): P77197
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: November 1, 1997
Last modified: July 31, 2019
This is version 164 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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