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Entry version 103 (10 Feb 2021)
Sequence version 4 (16 Jun 2009)
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Protein

Middle cell wall protein

Gene

BBR47_54160

Organism
Brevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The middle wall protein binds to peptidoglycan and to the outer cell wall protein.

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BBRE358681:G1G2J-5527-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Middle cell wall protein
Short name:
MWP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:BBR47_54160
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBrevibacillus brevis (strain 47 / JCM 6285 / NBRC 100599)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri358681 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaeBrevibacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001877 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell wall, S-layer, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Add BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003264224 – 1053Middle cell wall proteinAdd BLAST1030

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The middle cell wall layer is composed of subunits of the middle cell wall protein. These proteins form a hexagonal array with a lattice constant of 14.5 nM in the middle cell wall layers.

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
358681.BBR47_54160

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P06546

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 89SLH 1PROSITE-ProRule annotationAdd BLAST64
Domaini90 – 153SLH 2PROSITE-ProRule annotationAdd BLAST64
Domaini154 – 203SLH 3PROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG2373, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_286159_0_0_9

Database of Orthologous Groups

More...
OrthoDBi
149270at2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001119, SLH_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00395, SLH, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51272, SLH, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P06546-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKVVNSVLA SALALTVAPM AFAAEEAATT TAPKMDADME KTVKRLEALG
60 70 80 90 100
LVAGYGNGEY GVDKTITRAE FATLVVRARG LEQGAKLAQF SNTYTDVKST
110 120 130 140 150
DWFAGFVNVA SGEEIVKGFP DKSFKPQNQV TYAEAVTMIV RALGYEPSVK
160 170 180 190 200
GVWPNSMISK ASELNIARSI TTPNNAATRG DIFKMLDNAL RVDLMEQVEF
210 220 230 240 250
GTDIRHEITK ETLLTKYLKV TVRDMEWAQE AGNDSEDLPL VTNVPAIGLG
260 270 280 290 300
KIKANEVTLN GKDAGIGNTT YKVADGINAN DFDGQHVQVW IKDDKEDVIV
310 320 330 340 350
WMEGSTDQEV IMDRVGEFTL KGKTFEDPKD LSNSDLADLK LELDASEKSY
360 370 380 390 400
RFNKNTKVTY NFTRFNDPVD GLKEIIKDNA DGGFTFGAKV VLDNNNEIAY
410 420 430 440 450
IHVIDDQSMN KEDEGVKYGS EVISKIDTDK KKITNRDNDK FNDLDGKEEG
460 470 480 490 500
KDFLVFLNGK PAKFSDLKEG MVYSVYYADG DEDKLLVFAT DTVVEGKVDK
510 520 530 540 550
VVSRNNNDYR LTIGDKTYRV YEGATFSDDG NKDVQDIDKD HWDLVDSLDD
560 570 580 590 600
ETVKLYLDAS GRVRHIETKD AIDDRKQKAI VTRSATFNTS KDTWDFRVLT
610 620 630 640 650
QKGKEITVSL EAKNIYDFDG KNFSRDNKNQ DDLEDILVPS KDKDTLLLEV
660 670 680 690 700
TLDADGKPGK VEFLKPVKVE QESGKAWDDL ADEDDDMVGD YEVTDKTAVF
710 720 730 740 750
NMTGKLEESS KRKELKNAKT AKFKDVADEN DLSVIYTVND KDEVEAIFVV
760 770 780 790 800
EGDGLTGDAH YGQVIDFGRK GGKDTIRVWE KDGDKVVEKE YKLDGDQDDL
810 820 830 840 850
KDEDIRRNDF IAFTVDSNDE VVVDDVVEVV NKNAKGMLAE VTDEKGMKDA
860 870 880 890 900
NIDKMVVGLV SDVSKDTITY KDADDNKKKA SIKSATVYFD LYDDFGEADG
910 920 930 940 950
VNEGDYVVMI DSGDISGTKY DYVLIVSDAK TVRKDKLEDD AEAFLKQEPS
960 970 980 990 1000
EKPDPDTKWD ALPSKVEGKF TSAGPVKLYR ATVELNSKVK AEDVDAIEFY
1010 1020 1030 1040 1050
FNGKKVEPSL LNFKDGVITI GYNTEDKVTS SKIKVTNKNG KDSDEATVTF

VEA
Length:1,053
Mass (Da):117,078
Last modified:June 16, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F07E7A88C2DEF4F
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA22617 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti864S → R in AAA22760 (PubMed:2828336).Curated1
Sequence conflicti864S → R in AAA22372 (PubMed:2428810).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M19115 Genomic DNA Translation: AAA22760.1
AP008955 Genomic DNA Translation: BAH46393.1
M15364 Genomic DNA Translation: AAA87321.1
M14238 Genomic DNA Translation: AAA22372.1
M31828 Genomic DNA Translation: AAA22619.1
M32356 Genomic DNA Translation: AAA22617.1 Different initiation.
M32356 Genomic DNA Translation: AAA22618.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A28555

NCBI Reference Sequences

More...
RefSeqi
WP_015893589.1, NC_012491.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
BAH46393; BAH46393; BBR47_54160

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bbe:BBR47_54160

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19115 Genomic DNA Translation: AAA22760.1
AP008955 Genomic DNA Translation: BAH46393.1
M15364 Genomic DNA Translation: AAA87321.1
M14238 Genomic DNA Translation: AAA22372.1
M31828 Genomic DNA Translation: AAA22619.1
M32356 Genomic DNA Translation: AAA22617.1 Different initiation.
M32356 Genomic DNA Translation: AAA22618.1
PIRiA28555
RefSeqiWP_015893589.1, NC_012491.1

3D structure databases

SMRiP06546
ModBaseiSearch...

Protein-protein interaction databases

STRINGi358681.BBR47_54160

Genome annotation databases

EnsemblBacteriaiBAH46393; BAH46393; BBR47_54160
KEGGibbe:BBR47_54160

Phylogenomic databases

eggNOGiCOG2373, Bacteria
HOGENOMiCLU_286159_0_0_9
OrthoDBi149270at2

Enzyme and pathway databases

BioCyciBBRE358681:G1G2J-5527-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR001119, SLH_dom
PfamiView protein in Pfam
PF00395, SLH, 2 hits
PROSITEiView protein in PROSITE
PS51272, SLH, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLAPM_BREBN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06546
Secondary accession number(s): C0Z744, O31327, Q44953
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: June 16, 2009
Last modified: February 10, 2021
This is version 103 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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