UniProtKB - P06493 (CDK1_HUMAN)
Cyclin-dependent kinase 1
CDK1
Functioni
Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins (PubMed:16407259, PubMed:17459720, PubMed:16933150, PubMed:18356527, PubMed:19509060, PubMed:20171170, PubMed:19917720, PubMed:20937773, PubMed:20935635, PubMed:21063390, PubMed:23355470, PubMed:23601106, PubMed:23602554, PubMed:25556658, PubMed:26829474, PubMed:30704899).
Required in higher cells for entry into S-phase and mitosis (PubMed:16407259, PubMed:17459720, PubMed:16933150, PubMed:18356527, PubMed:19509060, PubMed:20171170, PubMed:19917720, PubMed:20937773, PubMed:20935635, PubMed:21063390, PubMed:23355470, PubMed:23601106, PubMed:23602554, PubMed:25556658).
Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, KAT5, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, TPPP, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2, CGAS and RUNX2 (PubMed:16407259, PubMed:17459720, PubMed:16933150, PubMed:18356527, PubMed:19509060, PubMed:20171170, PubMed:19917720, PubMed:20937773, PubMed:20935635, PubMed:21063390, PubMed:23355470, PubMed:23601106, PubMed:23602554, PubMed:25556658, PubMed:32351706, PubMed:26829474, PubMed:30704899).
CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs (PubMed:18480403, PubMed:20360007).
Essential for early stages of embryonic development (PubMed:18480403, PubMed:20360007).
During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation (PubMed:18480403, PubMed:20360007).
Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis (PubMed:18480403, PubMed:20360007).
Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair (PubMed:20360007).
Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression (PubMed:20395957).
In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons (PubMed:18356527).
The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis (PubMed:16371510).
NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation (PubMed:19509060).
In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis (PubMed:20171170).
The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis (PubMed:19917720).
In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis (PubMed:20937773).
This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes (PubMed:20937773).
EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing (PubMed:20935635).
CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration (By similarity).
CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230).
Regulates the amplitude of the cyclic expression of the core clock gene ARNTL/BMAL1 by phosphorylating its transcriptional repressor NR1D1, and this phosphorylation is necessary for SCF(FBXW7)-mediated ubiquitination and proteasomal degradation of NR1D1 (PubMed:27238018).
Phosphorylates EML3 at 'Thr-881' which is essential for its interaction with HAUS augmin-like complex and TUBG1 (PubMed:30723163).
Phosphorylates CGAS during mitosis, leading to its inhibition, thereby preventing CGAS activation by self DNA during mitosis (PubMed:32351706).
By similarity24 Publications(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry.
1 PublicationMiscellaneous
Catalytic activityi
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 33 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 128 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 10 – 18 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- chromatin binding Source: Ensembl
- cyclin binding Source: MGI
- cyclin-dependent protein kinase activity Source: UniProtKB
- cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
- histone kinase activity Source: UniProtKB
- Hsp70 protein binding Source: Ensembl
- protein kinase activity Source: UniProtKB
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: RHEA
- RNA polymerase II CTD heptapeptide repeat kinase activity Source: UniProtKB
- virus receptor activity Source: UniProtKB-KW
GO - Biological processi
- animal organ regeneration Source: Ensembl
- apoptotic process Source: UniProtKB-KW
- cell aging Source: Ensembl
- cell division Source: UniProtKB-KW
- cell migration Source: UniProtKB
- cell population proliferation Source: Ensembl
- cellular response to hydrogen peroxide Source: Ensembl
- centrosome cycle Source: UniProtKB
- chromosome condensation Source: Ensembl
- DNA repair Source: UniProtKB
- DNA replication Source: UniProtKB
- epithelial cell differentiation Source: UniProtKB
- ERK1 and ERK2 cascade Source: Reactome
- G2/M transition of mitotic cell cycle Source: GO_Central
- Golgi disassembly Source: UniProtKB
- microtubule cytoskeleton organization Source: UniProtKB
- mitotic G2 DNA damage checkpoint signaling Source: GO_Central
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of gene expression Source: Ensembl
- peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
- peptidyl-threonine phosphorylation Source: ParkinsonsUK-UCL
- positive regulation of cardiac muscle cell proliferation Source: Ensembl
- positive regulation of DNA replication Source: Ensembl
- positive regulation of G2/M transition of mitotic cell cycle Source: CAFA
- positive regulation of gene expression Source: Ensembl
- positive regulation of mitochondrial ATP synthesis coupled electron transport Source: CAFA
- positive regulation of protein import into nucleus Source: Ensembl
- positive regulation of protein localization to nucleus Source: UniProtKB
- pronuclear fusion Source: UniProtKB
- protein-containing complex assembly Source: Ensembl
- protein deubiquitination Source: Reactome
- protein localization to kinetochore Source: BHF-UCL
- protein phosphorylation Source: UniProtKB
- regulation of circadian rhythm Source: UniProtKB
- regulation of embryonic development Source: UniProtKB
- regulation of Schwann cell differentiation Source: UniProtKB
- response to activity Source: Ensembl
- response to amine Source: Ensembl
- response to axon injury Source: Ensembl
- response to cadmium ion Source: Ensembl
- response to copper ion Source: Ensembl
- response to ethanol Source: Ensembl
- response to organic cyclic compound Source: Ensembl
- response to toxic substance Source: Ensembl
- response to xenobiotic stimulus Source: Ensembl
- rhythmic process Source: UniProtKB-KW
- ventricular cardiac muscle cell development Source: Ensembl
Keywordsi
Molecular function | Host cell receptor for virus entry, Kinase, Receptor, Serine/threonine-protein kinase, Transferase |
Biological process | Apoptosis, Biological rhythms, Cell cycle, Cell division, Host-virus interaction, Mitosis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.22, 2681 |
PathwayCommonsi | P06493 |
Reactomei | R-HSA-110056, MAPK3 (ERK1) activation R-HSA-113507, E2F-enabled inhibition of pre-replication complex formation R-HSA-1362300, Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-162658, Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-170145, Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes R-HSA-174048, APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-176408, Regulation of APC/C activators between G1/S and early anaphase R-HSA-176412, Phosphorylation of the APC/C R-HSA-176417, Phosphorylation of Emi1 R-HSA-2299718, Condensation of Prophase Chromosomes R-HSA-2465910, MASTL Facilitates Mitotic Progression R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-2514853, Condensation of Prometaphase Chromosomes R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-2980767, Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2995383, Initiation of Nuclear Envelope (NE) Reformation R-HSA-3301854, Nuclear Pore Complex (NPC) Disassembly R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-4419969, Depolymerisation of the Nuclear Lamina R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689896, Ovarian tumor domain proteases R-HSA-6804114, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804757, Regulation of TP53 Degradation R-HSA-68875, Mitotic Prophase R-HSA-69205, G1/S-Specific Transcription R-HSA-69273, Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69478, G2/M DNA replication checkpoint R-HSA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854518, AURKA Activation by TPX2 R-HSA-8878166, Transcriptional regulation by RUNX2 |
SignaLinki | P06493 |
SIGNORi | P06493 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CDK1 Synonyms:CDC2, CDC28A, CDKN1, P34CDC2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1722, CDK1 |
MIMi | 116940, gene |
neXtProti | NX_P06493 |
VEuPathDBi | HostDB:ENSG00000170312 |
Subcellular locationi
Cytoskeleton
- centrosome 1 Publication
- spindle
Mitochondrion
- Mitochondrion 1 Publication
Cytoplasm and Cytosol
Nucleus
Note: Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage.
Cytoskeleton
- centrosome Source: UniProtKB
- mitotic spindle Source: UniProtKB
- spindle microtubule Source: UniProtKB
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Mitochondrion
- mitochondrial matrix Source: Ensembl
- mitochondrion Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: CACAO
Other locations
- chromosome, telomeric region Source: BHF-UCL
- cyclin B1-CDK1 complex Source: CAFA
- cyclin-dependent protein kinase holoenzyme complex Source: UniProtKB
- cytoplasm Source: CACAO
- membrane Source: UniProtKB
- midbody Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, Mitochondrion, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 4 | Y → D or E: Constitutive polyubiquitination. 1 Publication | 1 | |
Mutagenesisi | 14 – 15 | TY → AF: Abnormal cell cycle exhibiting only M-phase without completing either karyokinesis or cytokinesis. 1 Publication | 2 |
Organism-specific databases
DisGeNETi | 983 |
OpenTargetsi | ENSG00000170312 |
PharmGKBi | PA99 |
Miscellaneous databases
Pharosi | P06493, Tchem |
Chemistry databases
ChEMBLi | CHEMBL308 |
DrugBanki | DB04014, Alsterpaullone DB03496, Alvocidib DB08142, AT-7519 DB16652, Avotaciclib DB12010, Fostamatinib DB02950, Hymenialdisine DB02052, Indirubin-3'-monoxime DB02116, Olomoucine DB06195, Seliciclib DB03428, SU9516 |
DrugCentrali | P06493 |
GuidetoPHARMACOLOGYi | 1961 |
Genetic variation databases
BioMutai | CDK1 |
DMDMi | 334302921 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000085724 | 1 – 297 | Cyclin-dependent kinase 1Add BLAST | 297 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 | |
Modified residuei | 4 | Phosphotyrosine; by PKR1 Publication | 1 | |
Modified residuei | 6 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 6 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 9 | N6-acetyllysine; alternateBy similarity | 1 | |
Cross-linki | 9 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 14 | Phosphothreonine; by PKMYT1Combined sources1 Publication | 1 | |
Modified residuei | 15 | Phosphotyrosine; by PKMYT1, WEE1, WEE2 and PKC/PRKCDCombined sources2 Publications | 1 | |
Modified residuei | 19 | PhosphotyrosineCombined sources | 1 | |
Cross-linki | 20 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 39 | PhosphoserineCombined sources | 1 | |
Modified residuei | 77 | PhosphotyrosineCombined sources | 1 | |
Cross-linki | 139 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 141 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 161 | Phosphothreonine; by CAKCombined sources1 Publication | 1 | |
Modified residuei | 178 | PhosphoserineCombined sources | 1 | |
Modified residuei | 222 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 245 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 248 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
CPTACi | CPTAC-1040 CPTAC-1041 CPTAC-1042 CPTAC-1200 CPTAC-797 CPTAC-798 CPTAC-801 |
EPDi | P06493 |
jPOSTi | P06493 |
MassIVEi | P06493 |
MaxQBi | P06493 |
PaxDbi | P06493 |
PeptideAtlasi | P06493 |
PRIDEi | P06493 |
ProteomicsDBi | 51905 [P06493-1] 51906 [P06493-2] |
2D gel databases
SWISS-2DPAGEi | P06493 |
PTM databases
GlyGeni | P06493, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P06493 |
MetOSitei | P06493 |
PhosphoSitePlusi | P06493 |
SwissPalmi | P06493 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000170312, Expressed in ventricular zone and 186 other tissues |
ExpressionAtlasi | P06493, baseline and differential |
Genevisiblei | P06493, HS |
Organism-specific databases
HPAi | ENSG00000170312, Tissue enhanced (bone marrow, lymphoid tissue) |
Interactioni
Subunit structurei
Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin.
Interacts with cyclins-B (CCNB1, CCNB2 and CCNB3) to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Can also form CDK1-cylin-D and CDK1-cyclin-E complexes that phosphorylate RB1 in vitro. Binds to RB1 and other transcription factors such as FOXO1 and RUNX2. Promotes G2-M transition when in complex with a cyclin-B.
Interacts with DLGAP5. Binds to the CDK inhibitors CDKN1A/p21 and CDKN1B/p27. Isoform 2 is unable to complex with cyclin-B1 and also fails to bind to CDKN1A/p21.
Interacts with catalytically active CCNB1 and RALBP1 during mitosis to form an endocytotic complex during interphase. Associates with cyclins-A and B1 during S-phase in regenerating hepatocytes.
Interacts with FANCC.
Interacts with CEP63; this interaction recruits CDK1 to centrosomes.
Interacts with CENPA (PubMed:25556658).
Interacts with NR1D1 (PubMed:27238018).
Interacts with proteasome subunit PSMA8; to participate in meiosis progression during spermatogenesis (By similarity).
By similarity8 PublicationsBinary interactionsi
P06493
GO - Molecular functioni
- cyclin binding Source: MGI
- Hsp70 protein binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 107420, 394 interactors |
ComplexPortali | CPX-2003, Cyclin A1-CDK1 complex CPX-2004, Cyclin A2-CDK1 complex CPX-2007, Cyclin B1-CDK1 complex CPX-2008, Cyclin B2-CDK1 complex |
CORUMi | P06493 |
DIPi | DIP-35N |
ELMi | P06493 |
IntActi | P06493, 192 interactors |
MINTi | P06493 |
STRINGi | 9606.ENSP00000378699 |
Chemistry databases
BindingDBi | P06493 |
Miscellaneous databases
RNActi | P06493, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P06493 |
SMRi | P06493 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 4 – 287 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 284 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0594, Eukaryota |
GeneTreei | ENSGT00940000153335 |
HOGENOMi | CLU_000288_181_6_1 |
InParanoidi | P06493 |
OMAi | NNDVWPE |
OrthoDBi | 286319at2759 |
PhylomeDBi | P06493 |
TreeFami | TF101021 |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEDYTKIEKI GEGTYGVVYK GRHKTTGQVV AMKKIRLESE EEGVPSTAIR
60 70 80 90 100
EISLLKELRH PNIVSLQDVL MQDSRLYLIF EFLSMDLKKY LDSIPPGQYM
110 120 130 140 150
DSSLVKSYLY QILQGIVFCH SRRVLHRDLK PQNLLIDDKG TIKLADFGLA
160 170 180 190 200
RAFGIPIRVY THEVVTLWYR SPEVLLGSAR YSTPVDIWSI GTIFAELATK
210 220 230 240 250
KPLFHGDSEI DQLFRIFRAL GTPNNEVWPE VESLQDYKNT FPKWKPGSLA
260 270 280 290
SHVKNLDENG LDLLSKMLIY DPAKRISGKM ALNHPYFNDL DNQIKKM
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A024QZP7 | A0A024QZP7_HUMAN | Cell division cycle 2, G1 to S and ... | CDK1 CDC2, hCG_40242 | 297 | Annotation score: | ||
E5RIU6 | E5RIU6_HUMAN | Cyclin-dependent kinase 1 | CDK1 | 189 | Annotation score: |
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021375 | 107 – 163 | Missing in isoform 2. 1 PublicationAdd BLAST | 57 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X05360 mRNA Translation: CAA28963.1 Y00272 mRNA Translation: CAA68376.1 D88357 mRNA Translation: BAA26001.1 AK291939 mRNA Translation: BAF84628.1 BT007004 mRNA Translation: AAP35650.1 AF512554 Genomic DNA Translation: AAM34793.1 AC022390 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54204.1 Sequence problems. BC014563 mRNA Translation: AAH14563.1 |
CCDSi | CCDS44408.1 [P06493-1] CCDS7260.1 [P06493-2] |
PIRi | A29539 |
RefSeqi | NP_001307847.1, NM_001320918.1 [P06493-1] NP_001777.1, NM_001786.4 [P06493-1] NP_203698.1, NM_033379.4 [P06493-2] XP_005270360.1, XM_005270303.3 [P06493-1] |
Genome annotation databases
Ensembli | ENST00000316629.8; ENSP00000325970.4; ENSG00000170312.17 [P06493-2] ENST00000373809.2; ENSP00000362915.2; ENSG00000170312.17 [P06493-2] ENST00000395284.8; ENSP00000378699.3; ENSG00000170312.17 |
GeneIDi | 983 |
KEGGi | hsa:983 |
MANE-Selecti | ENST00000395284.8; ENSP00000378699.3; NM_001786.5; NP_001777.1 |
UCSCi | uc001jld.3, human [P06493-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X05360 mRNA Translation: CAA28963.1 Y00272 mRNA Translation: CAA68376.1 D88357 mRNA Translation: BAA26001.1 AK291939 mRNA Translation: BAF84628.1 BT007004 mRNA Translation: AAP35650.1 AF512554 Genomic DNA Translation: AAM34793.1 AC022390 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54204.1 Sequence problems. BC014563 mRNA Translation: AAH14563.1 |
CCDSi | CCDS44408.1 [P06493-1] CCDS7260.1 [P06493-2] |
PIRi | A29539 |
RefSeqi | NP_001307847.1, NM_001320918.1 [P06493-1] NP_001777.1, NM_001786.4 [P06493-1] NP_203698.1, NM_033379.4 [P06493-2] XP_005270360.1, XM_005270303.3 [P06493-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4Y72 | X-ray | 2.30 | A | 1-297 | [»] | |
4YC3 | X-ray | 2.70 | A | 1-297 | [»] | |
4YC6 | X-ray | 2.60 | A/C/E/G | 1-297 | [»] | |
5HQ0 | X-ray | 2.30 | A | 1-297 | [»] | |
5LQF | X-ray | 2.06 | A/D | 1-297 | [»] | |
6GU2 | X-ray | 2.00 | A | 1-297 | [»] | |
6GU3 | X-ray | 2.65 | A | 1-297 | [»] | |
6GU4 | X-ray | 2.73 | A | 1-297 | [»] | |
6GU6 | X-ray | 2.33 | A | 1-297 | [»] | |
6GU7 | X-ray | 2.75 | A/C/E/G | 1-297 | [»] | |
6TWN | X-ray | 2.28 | C/D | 207-223 | [»] | |
7NJ0 | electron microscopy | 3.60 | B | 1-297 | [»] | |
AlphaFoldDBi | P06493 | |||||
SMRi | P06493 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107420, 394 interactors |
ComplexPortali | CPX-2003, Cyclin A1-CDK1 complex CPX-2004, Cyclin A2-CDK1 complex CPX-2007, Cyclin B1-CDK1 complex CPX-2008, Cyclin B2-CDK1 complex |
CORUMi | P06493 |
DIPi | DIP-35N |
ELMi | P06493 |
IntActi | P06493, 192 interactors |
MINTi | P06493 |
STRINGi | 9606.ENSP00000378699 |
Chemistry databases
BindingDBi | P06493 |
ChEMBLi | CHEMBL308 |
DrugBanki | DB04014, Alsterpaullone DB03496, Alvocidib DB08142, AT-7519 DB16652, Avotaciclib DB12010, Fostamatinib DB02950, Hymenialdisine DB02052, Indirubin-3'-monoxime DB02116, Olomoucine DB06195, Seliciclib DB03428, SU9516 |
DrugCentrali | P06493 |
GuidetoPHARMACOLOGYi | 1961 |
Protein family/group databases
TCDBi | 1.I.1.1.3, the nuclear pore complex (npc) family |
PTM databases
GlyGeni | P06493, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P06493 |
MetOSitei | P06493 |
PhosphoSitePlusi | P06493 |
SwissPalmi | P06493 |
Genetic variation databases
BioMutai | CDK1 |
DMDMi | 334302921 |
2D gel databases
SWISS-2DPAGEi | P06493 |
Proteomic databases
CPTACi | CPTAC-1040 CPTAC-1041 CPTAC-1042 CPTAC-1200 CPTAC-797 CPTAC-798 CPTAC-801 |
EPDi | P06493 |
jPOSTi | P06493 |
MassIVEi | P06493 |
MaxQBi | P06493 |
PaxDbi | P06493 |
PeptideAtlasi | P06493 |
PRIDEi | P06493 |
ProteomicsDBi | 51905 [P06493-1] 51906 [P06493-2] |
Protocols and materials databases
Antibodypediai | 1134, 2691 antibodies from 49 providers |
CPTCi | P06493, 1 antibody |
DNASUi | 983 |
Genome annotation databases
Ensembli | ENST00000316629.8; ENSP00000325970.4; ENSG00000170312.17 [P06493-2] ENST00000373809.2; ENSP00000362915.2; ENSG00000170312.17 [P06493-2] ENST00000395284.8; ENSP00000378699.3; ENSG00000170312.17 |
GeneIDi | 983 |
KEGGi | hsa:983 |
MANE-Selecti | ENST00000395284.8; ENSP00000378699.3; NM_001786.5; NP_001777.1 |
UCSCi | uc001jld.3, human [P06493-1] |
Organism-specific databases
CTDi | 983 |
DisGeNETi | 983 |
GeneCardsi | CDK1 |
HGNCi | HGNC:1722, CDK1 |
HPAi | ENSG00000170312, Tissue enhanced (bone marrow, lymphoid tissue) |
MIMi | 116940, gene |
neXtProti | NX_P06493 |
OpenTargetsi | ENSG00000170312 |
PharmGKBi | PA99 |
VEuPathDBi | HostDB:ENSG00000170312 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0594, Eukaryota |
GeneTreei | ENSGT00940000153335 |
HOGENOMi | CLU_000288_181_6_1 |
InParanoidi | P06493 |
OMAi | NNDVWPE |
OrthoDBi | 286319at2759 |
PhylomeDBi | P06493 |
TreeFami | TF101021 |
Enzyme and pathway databases
BRENDAi | 2.7.11.22, 2681 |
PathwayCommonsi | P06493 |
Reactomei | R-HSA-110056, MAPK3 (ERK1) activation R-HSA-113507, E2F-enabled inhibition of pre-replication complex formation R-HSA-1362300, Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-162658, Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-170145, Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes R-HSA-174048, APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-176408, Regulation of APC/C activators between G1/S and early anaphase R-HSA-176412, Phosphorylation of the APC/C R-HSA-176417, Phosphorylation of Emi1 R-HSA-2299718, Condensation of Prophase Chromosomes R-HSA-2465910, MASTL Facilitates Mitotic Progression R-HSA-2500257, Resolution of Sister Chromatid Cohesion R-HSA-2514853, Condensation of Prometaphase Chromosomes R-HSA-2565942, Regulation of PLK1 Activity at G2/M Transition R-HSA-2980767, Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2995383, Initiation of Nuclear Envelope (NE) Reformation R-HSA-3301854, Nuclear Pore Complex (NPC) Disassembly R-HSA-380259, Loss of Nlp from mitotic centrosomes R-HSA-380270, Recruitment of mitotic centrosome proteins and complexes R-HSA-380284, Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320, Recruitment of NuMA to mitotic centrosomes R-HSA-4419969, Depolymerisation of the Nuclear Lamina R-HSA-5620912, Anchoring of the basal body to the plasma membrane R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689896, Ovarian tumor domain proteases R-HSA-6804114, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804757, Regulation of TP53 Degradation R-HSA-68875, Mitotic Prophase R-HSA-69205, G1/S-Specific Transcription R-HSA-69273, Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69478, G2/M DNA replication checkpoint R-HSA-75035, Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854518, AURKA Activation by TPX2 R-HSA-8878166, Transcriptional regulation by RUNX2 |
SignaLinki | P06493 |
SIGNORi | P06493 |
Miscellaneous databases
BioGRID-ORCSi | 983, 826 hits in 1071 CRISPR screens |
ChiTaRSi | CDK1, human |
GeneWikii | Cdk1 Cyclin-dependent_kinase_1 |
GenomeRNAii | 983 |
Pharosi | P06493, Tchem |
PROi | PR:P06493 |
RNActi | P06493, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170312, Expressed in ventricular zone and 186 other tissues |
ExpressionAtlasi | P06493, baseline and differential |
Genevisiblei | P06493, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CDK1_HUMAN | |
Accessioni | P06493Primary (citable) accession number: P06493 Secondary accession number(s): A8K7C4, C9J497, O60764 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | May 31, 2011 | |
Last modified: | May 25, 2022 | |
This is version 261 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families