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Protein

Cyclin-dependent kinase 1

Gene

CDK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2 and RUNX2. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. Essential for early stages of embryonic development. During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation. Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis. Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair. Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression. In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons. The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis. NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis. The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis. In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis. This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration. CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230).18 Publications
(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry.1 Publication

Miscellaneous

As a key regulator of the cell cycle, CDK1 is a potent therapeutic target for inhibitors in cancer treatment.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Activity regulationi

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it. Activated through a multistep process; binding to cyclin-B is required for relocation of cyclin-kinase complexes to the nucleus, activated by CAK/CDK7-mediated phosphorylation on Thr-161, and CDC25-mediated dephosphorylation of inhibitory phosphorylation on Thr-14 and Tyr-15. Inhibited by flavopiridol and derivatives, pyrimidine derivatives, pyridine derivatives, purine derivatives, staurosporine, paullones, oxoindoles, indazole analogs, indolin-2-ones, pyrazolo[3,4-b]pyridines, imidazo[1,2-a]pyridine (AZ703), thiazolinone analogs(RO-3306), thiazol urea, macrocyclic quinoxalin-2-one, pyrrolo[2,3-a]carbazole, pyrazolo[1,5-a]-1,3,5-triazine, pyrazolo[1,5-a]pyrimidine (Dinaciclib, SCH 727965), 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine), olomoucine, AG-024322, AT-7519, P276-00, R547/Ro-4584820 and SNS-032/BMS-387032. Repressed by the CDK inhibitors CDKN1A/p21 and CDKN1B/p27 during the G1 phase and by CDKN1A/p21 at the G1-S checkpoint upon DNA damage. Transient activation by rapid and transient dephosphorylation at Tyr-15 triggered by TGFB1.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei128Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHost cell receptor for virus entry, Kinase, Receptor, Serine/threonine-protein kinase, Transferase
Biological processApoptosis, Cell cycle, Cell division, Mitosis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.22 2681
ReactomeiR-HSA-110056 MAPK3 (ERK1) activation
R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization
R-HSA-170145 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase
R-HSA-176412 Phosphorylation of the APC/C
R-HSA-176417 Phosphorylation of Emi1
R-HSA-2299718 Condensation of Prophase Chromosomes
R-HSA-2465910 MASTL Facilitates Mitotic Progression
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2514853 Condensation of Prometaphase Chromosomes
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-4419969 Depolymerisation of the Nuclear Lamina
R-HSA-539107 Activation of E2F1 target genes at G1/S
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-5689896 Ovarian tumor domain proteases
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-68875 Mitotic Prophase
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-69478 G2/M DNA replication checkpoint
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854518 AURKA Activation by TPX2
R-HSA-8878166 Transcriptional regulation by RUNX2
SignaLinkiP06493
SIGNORiP06493

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase 1 (EC:2.7.11.22, EC:2.7.11.23)
Short name:
CDK1
Alternative name(s):
Cell division control protein 2 homolog
Cell division protein kinase 1
p34 protein kinase
Gene namesi
Name:CDK1
Synonyms:CDC2, CDC28A, CDKN1, P34CDC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000170312.15
HGNCiHGNC:1722 CDK1
MIMi116940 gene
neXtProtiNX_P06493

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Mitochondrion, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi4Y → D or E: Constitutive polyubiquitination. 1 Publication1
Mutagenesisi14 – 15TY → AF: Abnormal cell cycle exhibiting only M-phase without completing either karyokinesis or cytokinesis. 1 Publication2

Organism-specific databases

DisGeNETi983
OpenTargetsiENSG00000170312
PharmGKBiPA99

Chemistry databases

ChEMBLiCHEMBL308
DrugBankiDB04014 Alsterpaullone
DB05037 AT7519
DB03496 Flavopiridol
DB02950 Hymenialdisine
DB02052 Indirubin-3'-Monoxime
DB02116 Olomoucine
DB03428 SU9516
GuidetoPHARMACOLOGYi1961

Polymorphism and mutation databases

BioMutaiCDK1
DMDMi334302921

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857241 – 297Cyclin-dependent kinase 1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei4Phosphotyrosine; by PKR1 Publication1
Modified residuei6N6-acetyllysine; alternateCombined sources1
Cross-linki6Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei9N6-acetyllysine; alternateBy similarity1
Cross-linki9Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei14Phosphothreonine; by PKMYT1Combined sources1 Publication1
Modified residuei15Phosphotyrosine; by PKMYT1, WEE1, WEE2 and PKC/PRKCDCombined sources2 Publications1
Modified residuei19PhosphotyrosineCombined sources1
Cross-linki20Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei39PhosphoserineCombined sources1
Modified residuei77PhosphotyrosineCombined sources1
Cross-linki139Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei141PhosphothreonineCombined sources1
Modified residuei161Phosphothreonine; by CAKCombined sources1 Publication1
Modified residuei178PhosphoserineCombined sources1
Modified residuei222PhosphothreonineCombined sources1
Modified residuei245N6-succinyllysineBy similarity1
Modified residuei248PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation at Thr-161 by CAK/CDK7 activates kinase activity. Phosphorylation at Thr-14 and Tyr-15 by PKMYT1 prevents nuclear translocation. Phosphorylation at Tyr-15 by WEE1 and WEE2 inhibits the protein kinase activity and acts as a negative regulator of entry into mitosis (G2 to M transition). Phosphorylation by PKMYT1 and WEE1 takes place during mitosis to keep CDK1-cyclin-B complexes inactive until the end of G2. By the end of G2, PKMYT1 and WEE1 are inactivated, but CDC25A and CDC25B are activated. Dephosphorylation by active CDC25A and CDC25B at Thr-14 and Tyr-15, leads to CDK1 activation at the G2-M transition. Phosphorylation at Tyr-15 by WEE2 during oogenesis is required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, leading to prevent meiotic reentry. Phosphorylation by WEE2 is also required for metaphase II exit during egg activation to ensure exit from meiosis in oocytes and promote pronuclear formation. Phosphorylated at Tyr-4 by PKR/EIF2AK2 upon genotoxic stress. This phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest. In response to UV irradiation, phosphorylation at Tyr-15 by PRKCD activates the G2/M DNA damage checkpoint.5 Publications
Polyubiquitinated upon genotoxic stress.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP06493
MaxQBiP06493
PaxDbiP06493
PeptideAtlasiP06493
PRIDEiP06493
ProteomicsDBi51905
51906 [P06493-2]

2D gel databases

SWISS-2DPAGEiP06493

PTM databases

iPTMnetiP06493
PhosphoSitePlusiP06493
SwissPalmiP06493

Expressioni

Tissue specificityi

Isoform 2 is found in breast cancer tissues.

Inductioni

Follows a cyclic expression; during interphase, accumulates gradually following G1, S to reach a critical threshold at the end of G2, which promotes self-activation and triggers onset of mitosis. Induced transiently by TGFB1 at an early phase of TGFB1-mediated apoptosis, but later repressed. Triggered by CKS1B during mitotic entry in breast cancer cells. Down-regulated under genotoxic stresses triggered by PKR/EIF2AK2-mediated phosphorylation.2 Publications

Gene expression databases

BgeeiENSG00000170312 Expressed in 172 organ(s), highest expression level in intestine
CleanExiHS_CDC2
ExpressionAtlasiP06493 baseline and differential
GenevisibleiP06493 HS

Organism-specific databases

HPAiCAB003799
HPA003387

Interactioni

Subunit structurei

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cyclins-B (CCNB1, CCNB2 and CCNB3) to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Can also form CDK1-cylin-D and CDK1-cyclin-E complexes that phosphorylate RB1 in vitro. Binds to RB1 and other transcription factors such as FOXO1 and RUNX2. Promotes G2-M transition when in complex with a cyclin-B. Interacts with DLGAP5. Binds to the CDK inhibitors CDKN1A/p21 and CDKN1B/p27. Isoform 2 is unable to complex with cyclin-B1 and also fails to bind to CDKN1A/p21. Interacts with catalytically active CCNB1 and RALBP1 during mitosis to form an endocytotic complex during interphase. Associates with cyclins-A and B1 during S-phase in regenerating hepatocytes. Interacts with FANCC. Interacts with CEP63; this interaction recruits CDK1 to centrosomes. Interacts with CENPA (PubMed:25556658).7 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107420, 275 interactors
ComplexPortaliCPX-2003 Cyclin A1-CDK1 complex
CPX-2004 Cyclin A2-CDK1 complex
CPX-2007 Cyclin B1-CDK1 complex
CPX-2008 Cyclin B2-CDK1 complex
CORUMiP06493
DIPiDIP-35N
ELMiP06493
IntActiP06493, 129 interactors
MINTiP06493
STRINGi9606.ENSP00000378699

Chemistry databases

BindingDBiP06493

Structurei

Secondary structure

1297
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP06493
SMRiP06493
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 287Protein kinasePROSITE-ProRule annotationAdd BLAST284

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0594 Eukaryota
ENOG410XPP3 LUCA
GeneTreeiENSGT00910000144030
HOVERGENiHBG014652
InParanoidiP06493
KOiK02087
OMAiSMLIYDP
PhylomeDBiP06493
TreeFamiTF101021

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P06493-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDYTKIEKI GEGTYGVVYK GRHKTTGQVV AMKKIRLESE EEGVPSTAIR
60 70 80 90 100
EISLLKELRH PNIVSLQDVL MQDSRLYLIF EFLSMDLKKY LDSIPPGQYM
110 120 130 140 150
DSSLVKSYLY QILQGIVFCH SRRVLHRDLK PQNLLIDDKG TIKLADFGLA
160 170 180 190 200
RAFGIPIRVY THEVVTLWYR SPEVLLGSAR YSTPVDIWSI GTIFAELATK
210 220 230 240 250
KPLFHGDSEI DQLFRIFRAL GTPNNEVWPE VESLQDYKNT FPKWKPGSLA
260 270 280 290
SHVKNLDENG LDLLSKMLIY DPAKRISGKM ALNHPYFNDL DNQIKKM
Length:297
Mass (Da):34,095
Last modified:May 31, 2011 - v3
Checksum:i942D79448EFE490A
GO
Isoform 2 (identifier: P06493-2) [UniParc]FASTAAdd to basket
Also known as: CDC2deltaT

The sequence of this isoform differs from the canonical sequence as follows:
     107-163: Missing.

Show »
Length:240
Mass (Da):27,503
Checksum:i50FC3D192024E38C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A024QZP7A0A024QZP7_HUMAN
Cell division cycle 2, G1 to S and ...
CDK1 CDC2, hCG_40242
297Annotation score:
E5RIU6E5RIU6_HUMAN
Cyclin-dependent kinase 1
CDK1
189Annotation score:
A0A087WZZ9A0A087WZZ9_HUMAN
Cyclin-dependent kinase 1
CDK1
224Annotation score:

Sequence cautioni

The sequence EAW54204 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021375107 – 163Missing in isoform 2. 1 PublicationAdd BLAST57

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05360 mRNA Translation: CAA28963.1
Y00272 mRNA Translation: CAA68376.1
D88357 mRNA Translation: BAA26001.1
AK291939 mRNA Translation: BAF84628.1
BT007004 mRNA Translation: AAP35650.1
AF512554 Genomic DNA Translation: AAM34793.1
AC022390 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54204.1 Sequence problems.
BC014563 mRNA Translation: AAH14563.1
CCDSiCCDS44408.1 [P06493-1]
CCDS7260.1 [P06493-2]
PIRiA29539
RefSeqiNP_001307847.1, NM_001320918.1 [P06493-1]
NP_001777.1, NM_001786.4 [P06493-1]
NP_203698.1, NM_033379.4 [P06493-2]
XP_005270360.1, XM_005270303.3 [P06493-1]
UniGeneiHs.732435

Genome annotation databases

EnsembliENST00000316629; ENSP00000325970; ENSG00000170312 [P06493-2]
ENST00000373809; ENSP00000362915; ENSG00000170312 [P06493-2]
ENST00000395284; ENSP00000378699; ENSG00000170312 [P06493-1]
GeneIDi983
KEGGihsa:983
UCSCiuc001jld.3 human [P06493-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05360 mRNA Translation: CAA28963.1
Y00272 mRNA Translation: CAA68376.1
D88357 mRNA Translation: BAA26001.1
AK291939 mRNA Translation: BAF84628.1
BT007004 mRNA Translation: AAP35650.1
AF512554 Genomic DNA Translation: AAM34793.1
AC022390 Genomic DNA No translation available.
CH471083 Genomic DNA Translation: EAW54204.1 Sequence problems.
BC014563 mRNA Translation: AAH14563.1
CCDSiCCDS44408.1 [P06493-1]
CCDS7260.1 [P06493-2]
PIRiA29539
RefSeqiNP_001307847.1, NM_001320918.1 [P06493-1]
NP_001777.1, NM_001786.4 [P06493-1]
NP_203698.1, NM_033379.4 [P06493-2]
XP_005270360.1, XM_005270303.3 [P06493-1]
UniGeneiHs.732435

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LC9model-A1-297[»]
4Y72X-ray2.30A1-297[»]
4YC3X-ray2.70A1-297[»]
4YC6X-ray2.60A/C/E/G1-297[»]
5HQ0X-ray2.30A1-297[»]
5LQFX-ray2.06A/D1-297[»]
ProteinModelPortaliP06493
SMRiP06493
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107420, 275 interactors
ComplexPortaliCPX-2003 Cyclin A1-CDK1 complex
CPX-2004 Cyclin A2-CDK1 complex
CPX-2007 Cyclin B1-CDK1 complex
CPX-2008 Cyclin B2-CDK1 complex
CORUMiP06493
DIPiDIP-35N
ELMiP06493
IntActiP06493, 129 interactors
MINTiP06493
STRINGi9606.ENSP00000378699

Chemistry databases

BindingDBiP06493
ChEMBLiCHEMBL308
DrugBankiDB04014 Alsterpaullone
DB05037 AT7519
DB03496 Flavopiridol
DB02950 Hymenialdisine
DB02052 Indirubin-3'-Monoxime
DB02116 Olomoucine
DB03428 SU9516
GuidetoPHARMACOLOGYi1961

Protein family/group databases

TCDBi1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetiP06493
PhosphoSitePlusiP06493
SwissPalmiP06493

Polymorphism and mutation databases

BioMutaiCDK1
DMDMi334302921

2D gel databases

SWISS-2DPAGEiP06493

Proteomic databases

EPDiP06493
MaxQBiP06493
PaxDbiP06493
PeptideAtlasiP06493
PRIDEiP06493
ProteomicsDBi51905
51906 [P06493-2]

Protocols and materials databases

DNASUi983
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316629; ENSP00000325970; ENSG00000170312 [P06493-2]
ENST00000373809; ENSP00000362915; ENSG00000170312 [P06493-2]
ENST00000395284; ENSP00000378699; ENSG00000170312 [P06493-1]
GeneIDi983
KEGGihsa:983
UCSCiuc001jld.3 human [P06493-1]

Organism-specific databases

CTDi983
DisGeNETi983
EuPathDBiHostDB:ENSG00000170312.15
GeneCardsiCDK1
HGNCiHGNC:1722 CDK1
HPAiCAB003799
HPA003387
MIMi116940 gene
neXtProtiNX_P06493
OpenTargetsiENSG00000170312
PharmGKBiPA99
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0594 Eukaryota
ENOG410XPP3 LUCA
GeneTreeiENSGT00910000144030
HOVERGENiHBG014652
InParanoidiP06493
KOiK02087
OMAiSMLIYDP
PhylomeDBiP06493
TreeFamiTF101021

Enzyme and pathway databases

BRENDAi2.7.11.22 2681
ReactomeiR-HSA-110056 MAPK3 (ERK1) activation
R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization
R-HSA-170145 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase
R-HSA-176412 Phosphorylation of the APC/C
R-HSA-176417 Phosphorylation of Emi1
R-HSA-2299718 Condensation of Prophase Chromosomes
R-HSA-2465910 MASTL Facilitates Mitotic Progression
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2514853 Condensation of Prometaphase Chromosomes
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-4419969 Depolymerisation of the Nuclear Lamina
R-HSA-539107 Activation of E2F1 target genes at G1/S
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5687128 MAPK6/MAPK4 signaling
R-HSA-5689896 Ovarian tumor domain proteases
R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-HSA-6804757 Regulation of TP53 Degradation
R-HSA-68875 Mitotic Prophase
R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-HSA-69478 G2/M DNA replication checkpoint
R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint
R-HSA-8854518 AURKA Activation by TPX2
R-HSA-8878166 Transcriptional regulation by RUNX2
SignaLinkiP06493
SIGNORiP06493

Miscellaneous databases

ChiTaRSiCDK1 human
GeneWikiiCdk1
Cyclin-dependent_kinase_1
GenomeRNAii983
PROiPR:P06493
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170312 Expressed in 172 organ(s), highest expression level in intestine
CleanExiHS_CDC2
ExpressionAtlasiP06493 baseline and differential
GenevisibleiP06493 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCDK1_HUMAN
AccessioniPrimary (citable) accession number: P06493
Secondary accession number(s): A8K7C4, C9J497, O60764
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: May 31, 2011
Last modified: November 7, 2018
This is version 237 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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