CDK1

Functionⁱ

Plays a key role in the control of the eukaryotic cell cycle by modulating the centrosome cycle as well as mitotic onset; promotes G2-M transition, and regulates G1 progress and G1-S transition via association with multiple interphase cyclins. Required in higher cells for entry into S-phase and mitosis. Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C, CC2D1A, CENPA, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1, DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG, FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1 proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR, LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC, NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1, NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53, NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, UL40/R2, RAB4A, RAP1GAP, RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin, STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1, FOXO1, RUNX1/AML1, SAMHD1, SIRT2 and RUNX2. CDK1/CDC2-cyclin-B controls pronuclear union in interphase fertilized eggs. Essential for early stages of embryonic development. During G2 and early mitosis, CDC25A/B/C-mediated dephosphorylation activates CDK1/cyclin complexes which phosphorylate several substrates that trigger at least centrosome separation, Golgi dynamics, nuclear envelope breakdown and chromosome condensation. Once chromosomes are condensed and aligned at the metaphase plate, CDK1 activity is switched off by WEE1- and PKMYT1-mediated phosphorylation to allow sister chromatid separation, chromosome decondensation, reformation of the nuclear envelope and cytokinesis. Inactivated by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage to stop cell cycle and genome replication at the G2 checkpoint thus facilitating DNA repair. Reactivated after successful DNA repair through WIP1-dependent signaling leading to CDC25A/B/C-mediated dephosphorylation and restoring cell cycle progression. In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the G2-M phase represses FOXO1 interaction with 14-3-3 proteins and thereby promotes FOXO1 nuclear accumulation and transcription factor activity, leading to cell death of postmitotic neurons. The phosphorylation of beta-tubulins regulates microtubule dynamics during mitosis. NEDD1 phosphorylation promotes PLK1-mediated NEDD1 phosphorylation and subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. In addition, CC2D1A phosphorylation regulates CC2D1A spindle pole localization and association with SCC1/RAD21 and centriole cohesion during mitosis. The phosphorylation of Bcl-xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers apoptosis. In contrast, CASP8 phosphorylation during mitosis prevents its activation by proteolysis and subsequent apoptosis. This phosphorylation occurs in cancer cell lines, as well as in primary breast tissues and lymphocytes. EZH2 phosphorylation promotes H3K27me3 maintenance and epigenetic gene silencing. CALD1 phosphorylation promotes Schwann cell migration during peripheral nerve regeneration. CDK1-cyclin-B complex phosphorylates NCKAP5L and mediates its dissociation from centrosomes during mitosis (PubMed:26549230).18 Publications

Miscellaneous

As a key regulator of the cell cycle, CDK1 is a potent therapeutic target for inhibitors in cancer treatment.1 Publication

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Activity regulationⁱ

Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-161 activates it. Activated through a multistep process; binding to cyclin-B is required for relocation of cyclin-kinase complexes to the nucleus, activated by CAK/CDK7-mediated phosphorylation on Thr-161, and CDC25-mediated dephosphorylation of inhibitory phosphorylation on Thr-14 and Tyr-15. Inhibited by flavopiridol and derivatives, pyrimidine derivatives, pyridine derivatives, purine derivatives, staurosporine, paullones, oxoindoles, indazole analogs, indolin-2-ones, pyrazolo[3,4-b]pyridines, imidazo[1,2-a]pyridine (AZ703), thiazolinone analogs(RO-3306), thiazol urea, macrocyclic quinoxalin-2-one, pyrrolo[2,3-a]carbazole, pyrazolo[1,5-a]-1,3,5-triazine, pyrazolo[1,5-a]pyrimidine (Dinaciclib, SCH 727965), 2-(1-ethyl-2-hydroxyethylamino)-6-benzylamino-9-isopropylpurine (roscovitine), olomoucine, AG-024322, AT-7519, P276-00, R547/Ro-4584820 and SNS-032/BMS-387032. Repressed by the CDK inhibitors CDKN1A/p21 and CDKN1B/p27 during the G1 phase and by CDKN1A/p21 at the G1-S checkpoint upon DNA damage. Transient activation by rapid and transient dephosphorylation at Tyr-15 triggered by TGFB1.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	33	ATPPROSITE-ProRule annotation		1
Active siteⁱ	128	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	10 – 18	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
chromatin binding Source: Ensembl
cyclin binding
Source: MGI
Inferred from direct assayⁱ
- 7739547
cyclin-dependent protein kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 1312467
cyclin-dependent protein serine/threonine kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
histone kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 21871177
Hsp70 protein binding Source: Ensembl
protein kinase activity
Source: MGI
Inferred from direct assayⁱ
- 22854038
protein serine/threonine kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 21871177
RNA polymerase II CTD heptapeptide repeat kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 12721286
virus receptor activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of MAPK activity Source: Reactome
anaphase-promoting complex-dependent catabolic process Source: Reactome
animal organ regeneration Source: Ensembl
apoptotic process Source: UniProtKB-KW
cell aging Source: Ensembl
cell division Source: UniProtKB-KW
cell migration
Source: UniProtKB
Traceable author statementⁱ
- 17200138
cell proliferation Source: Ensembl
cellular response to hydrogen peroxide Source: Ensembl
centrosome cycle
Source: UniProtKB
Traceable author statementⁱ
- 19364923
chromosome condensation Source: Ensembl
ciliary basal body-plasma membrane docking Source: Reactome
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
DNA repair
Source: UniProtKB
Traceable author statementⁱ
- 21655336
DNA replication
Source: UniProtKB
Traceable author statementⁱ
- 21655336
epithelial cell differentiation
Source: UniProtKB
Inferred from expression patternⁱ
- 21492153
G2/M transition of mitotic cell cycle Source: Reactome
Golgi disassembly Source: UniProtKB
microtubule cytoskeleton organization
Source: UniProtKB
Traceable author statementⁱ
- 21655336
mitotic cell cycle phase transition
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mitotic G2 DNA damage checkpoint Source: Ensembl
mitotic nuclear envelope disassembly Source: Reactome
negative regulation of apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 11069302
peptidyl-serine phosphorylation
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 11298763
peptidyl-threonine phosphorylation
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 11298763
positive regulation of cardiac muscle cell proliferation Source: Ensembl
positive regulation of DNA replication Source: Ensembl
positive regulation of G2/M transition of mitotic cell cycle
Source: CAFA
Inferred from mutant phenotypeⁱ
- 24746669
positive regulation of gene expression Source: Ensembl
positive regulation of mitochondrial ATP synthesis coupled electron transport
Source: CAFA
Inferred from mutant phenotypeⁱ
- 24746669
positive regulation of protein import into nucleus, translocation Source: Ensembl
positive regulation of protein localization to nucleus
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21871177
pronuclear fusion
Source: UniProtKB
Traceable author statementⁱ
- 21535261
protein-containing complex assembly Source: Ensembl
protein deubiquitination Source: Reactome
protein localization to kinetochore
Source: BHF-UCL
Inferred from direct assayⁱ
- 18195732
protein phosphorylation
Source: CAFA
Inferred from mutant phenotypeⁱ
- 24746669
regulation of embryonic development
Source: UniProtKB
Traceable author statementⁱ
- 21535261
regulation of G2/M transition of mitotic cell cycle Source: Reactome
regulation of Schwann cell differentiation
Source: UniProtKB
Traceable author statementⁱ
- 17200138
response to activity Source: Ensembl
response to amine Source: Ensembl
response to axon injury Source: Ensembl
response to cadmium ion Source: Ensembl
response to copper ion Source: Ensembl
response to ethanol Source: Ensembl
response to organic cyclic compound Source: Ensembl
ventricular cardiac muscle cell development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Host cell receptor for virus entry, Kinase, Receptor, Serine/threonine-protein kinase, Transferase
Biological process	Apoptosis, Cell cycle, Cell division, Mitosis
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.11.22 2681
Reactomeⁱ	R-HSA-110056 MAPK3 (ERK1) activation R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-170145 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase R-HSA-176412 Phosphorylation of the APC/C R-HSA-176417 Phosphorylation of Emi1 R-HSA-2299718 Condensation of Prophase Chromosomes R-HSA-2465910 MASTL Facilitates Mitotic Progression R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2514853 Condensation of Prometaphase Chromosomes R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320 Recruitment of NuMA to mitotic centrosomes R-HSA-4419969 Depolymerisation of the Nuclear Lamina R-HSA-539107 Activation of E2F1 target genes at G1/S R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-5687128 MAPK6/MAPK4 signaling R-HSA-5689896 Ovarian tumor domain proteases R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804757 Regulation of TP53 Degradation R-HSA-68875 Mitotic Prophase R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69478 G2/M DNA replication checkpoint R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854518 AURKA Activation by TPX2 R-HSA-8878166 Transcriptional regulation by RUNX2
SignaLinkⁱ	P06493
SIGNORⁱ	P06493

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cyclin-dependent kinase 1 (EC:2.7.11.22, EC:2.7.11.23) Short name: CDK1 Alternative name(s): Cell division control protein 2 homolog Cell division protein kinase 1 p34 protein kinase
Gene namesⁱ	Name:CDK1 Synonyms:CDC2, CDC28A, CDKN1, P34CDC2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000170312.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1722 CDK1
MIMⁱ	116940 gene
neXtProtⁱ	NX_P06493

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Mitochondrion, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	4	Y → D or E: Constitutive polyubiquitination. 1 Publication		1
Mutagenesisⁱ	14 – 15	TY → AF: Abnormal cell cycle exhibiting only M-phase without completing either karyokinesis or cytokinesis. 1 Publication		2

Organism-specific databases

DisGeNET More...DisGeNETⁱ	983
Open Targets More...OpenTargetsⁱ	ENSG00000170312
PharmGKBⁱ	PA99

Chemistry databases

ChEMBLⁱ	CHEMBL308
Drug and drug target database More...DrugBankⁱ	DB04014 Alsterpaullone DB05037 AT7519 DB03496 Flavopiridol DB02950 Hymenialdisine DB02052 Indirubin-3'-Monoxime DB02116 Olomoucine DB03428 SU9516
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1961

Polymorphism and mutation databases

BioMutaⁱ	CDK1
DMDMⁱ	334302921

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000085724	1 – 297	Cyclin-dependent kinase 1Add BLAST		297

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	4	Phosphotyrosine; by PKR1 Publication	1
Modified residueⁱ	6	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	6	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	9	N6-acetyllysine; alternateBy similarity	1
Cross-linkⁱ	9	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residueⁱ	14	Phosphothreonine; by PKMYT1Combined sources1 Publication	1
Modified residueⁱ	15	Phosphotyrosine; by PKMYT1, WEE1, WEE2 and PKC/PRKCDCombined sources2 Publications	1
Modified residueⁱ	19	PhosphotyrosineCombined sources	1
Cross-linkⁱ	20	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	39	PhosphoserineCombined sources	1
Modified residueⁱ	77	PhosphotyrosineCombined sources	1
Cross-linkⁱ	139	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	141	PhosphothreonineCombined sources	1
Modified residueⁱ	161	Phosphothreonine; by CAKCombined sources1 Publication	1
Modified residueⁱ	178	PhosphoserineCombined sources	1
Modified residueⁱ	222	PhosphothreonineCombined sources	1
Modified residueⁱ	245	N6-succinyllysineBy similarity	1
Modified residueⁱ	248	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylation at Thr-161 by CAK/CDK7 activates kinase activity. Phosphorylation at Thr-14 and Tyr-15 by PKMYT1 prevents nuclear translocation. Phosphorylation at Tyr-15 by WEE1 and WEE2 inhibits the protein kinase activity and acts as a negative regulator of entry into mitosis (G2 to M transition). Phosphorylation by PKMYT1 and WEE1 takes place during mitosis to keep CDK1-cyclin-B complexes inactive until the end of G2. By the end of G2, PKMYT1 and WEE1 are inactivated, but CDC25A and CDC25B are activated. Dephosphorylation by active CDC25A and CDC25B at Thr-14 and Tyr-15, leads to CDK1 activation at the G2-M transition. Phosphorylation at Tyr-15 by WEE2 during oogenesis is required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, leading to prevent meiotic reentry. Phosphorylation by WEE2 is also required for metaphase II exit during egg activation to ensure exit from meiosis in oocytes and promote pronuclear formation. Phosphorylated at Tyr-4 by PKR/EIF2AK2 upon genotoxic stress. This phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest. In response to UV irradiation, phosphorylation at Tyr-15 by PRKCD activates the G2/M DNA damage checkpoint.5 Publications

Polyubiquitinated upon genotoxic stress.1 Publication

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P06493
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P06493
PaxDbⁱ	P06493
PeptideAtlas More...PeptideAtlasⁱ	P06493
PRIDEⁱ	P06493
ProteomicsDBⁱ	51905 51906 [P06493-2]

2D gel databases

SWISS-2DPAGEⁱ	P06493

SWISS-2DPAGEⁱ

P06493

PTM databases

iPTMnetⁱ	P06493
PhosphoSitePlusⁱ	P06493
SwissPalmⁱ	P06493

Expressionⁱ

Tissue specificityⁱ

Isoform 2 is found in breast cancer tissues.

Inductionⁱ

Follows a cyclic expression; during interphase, accumulates gradually following G1, S to reach a critical threshold at the end of G2, which promotes self-activation and triggers onset of mitosis. Induced transiently by TGFB1 at an early phase of TGFB1-mediated apoptosis, but later repressed. Triggered by CKS1B during mitotic entry in breast cancer cells. Down-regulated under genotoxic stresses triggered by PKR/EIF2AK2-mediated phosphorylation.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000170312 Expressed in 172 organ(s), highest expression level in intestine
CleanExⁱ	HS_CDC2
ExpressionAtlasⁱ	P06493 baseline and differential
Genevisibleⁱ	P06493 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB003799 HPA003387

HPAⁱ

CAB003799
HPA003387

Interactionⁱ

Subunit structureⁱ

Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cyclins-B (CCNB1, CCNB2 and CCNB3) to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex. Can also form CDK1-cylin-D and CDK1-cyclin-E complexes that phosphorylate RB1 in vitro. Binds to RB1 and other transcription factors such as FOXO1 and RUNX2. Promotes G2-M transition when in complex with a cyclin-B. Interacts with DLGAP5. Binds to the CDK inhibitors CDKN1A/p21 and CDKN1B/p27. Isoform 2 is unable to complex with cyclin-B1 and also fails to bind to CDKN1A/p21. Interacts with catalytically active CCNB1 and RALBP1 during mitosis to form an endocytotic complex during interphase. Associates with cyclins-A and B1 during S-phase in regenerating hepatocytes. Interacts with FANCC. Interacts with CEP63; this interaction recruits CDK1 to centrosomes. Interacts with CENPA (PubMed:25556658).7 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	P03070	2	EBI-444308,EBI-617698	From Simian virus 40.
ALYREF	Q86V81	4	EBI-444308,EBI-347640
BIRC5	O15392	6	EBI-444308,EBI-518823
CCNB1	P14635	19	EBI-444308,EBI-495332
CDC25C	P30307	2	EBI-444308,EBI-974439
CDC6	Q99741	2	EBI-444308,EBI-374862
CDKN1A	P38936	3	EBI-444308,EBI-375077
CKS1B	P61024	8	EBI-444308,EBI-456371
DEDD	O75618-1	2	EBI-444308,EBI-15621191
DLST	P36957	3	EBI-444308,EBI-351007
EIF2AK2	P19525	4	EBI-444308,EBI-640775
FOXO1	Q12778	5	EBI-444308,EBI-1108782
LATS1	O95835	3	EBI-444308,EBI-444209
PKMYT1	Q99640	4	EBI-444308,EBI-495308
UBC	P0CG48	6	EBI-444308,EBI-3390054
VDAC1	P21796	3	EBI-444308,EBI-354158

GO - Molecular functionⁱ

cyclin binding
Source: MGI
Inferred from direct assayⁱ
- 7739547
Hsp70 protein binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107420, 275 interactors
ComplexPortalⁱ	CPX-2003 Cyclin A1-CDK1 complex CPX-2004 Cyclin A2-CDK1 complex CPX-2007 Cyclin B1-CDK1 complex CPX-2008 Cyclin B2-CDK1 complex
CORUMⁱ	P06493
Database of interacting proteins More...DIPⁱ	DIP-35N
ELMⁱ	P06493
IntActⁱ	P06493, 129 interactors
Molecular INTeraction database More...MINTⁱ	P06493
STRINGⁱ	9606.ENSP00000378699

Chemistry databases

BindingDBⁱ

P06493

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	1 – 3	Combined sources	3
Beta strandⁱ	4 – 12	Combined sources	9
Beta strandⁱ	17 – 23	Combined sources	7
Turnⁱ	24 – 26	Combined sources	3
Beta strandⁱ	29 – 34	Combined sources	6
Helixⁱ	40 – 42	Combined sources	3
Helixⁱ	46 – 57	Combined sources	12
Beta strandⁱ	66 – 72	Combined sources	7
Beta strandⁱ	75 – 81	Combined sources	7
Beta strandⁱ	84 – 86	Combined sources	3
Helixⁱ	87 – 92	Combined sources	6
Helixⁱ	102 – 120	Combined sources	19
Turnⁱ	121 – 123	Combined sources	3
Helixⁱ	131 – 133	Combined sources	3
Beta strandⁱ	134 – 136	Combined sources	3
Beta strandⁱ	142 – 144	Combined sources	3
Helixⁱ	149 – 152	Combined sources	4
Beta strandⁱ	155 – 157	Combined sources	3
Turnⁱ	161 – 163	Combined sources	3
Helixⁱ	166 – 169	Combined sources	4
Helixⁱ	172 – 175	Combined sources	4
Beta strandⁱ	179 – 181	Combined sources	3
Helixⁱ	184 – 199	Combined sources	16
Helixⁱ	209 – 220	Combined sources	12
Turnⁱ	225 – 227	Combined sources	3
Helixⁱ	231 – 233	Combined sources	3
Helixⁱ	249 – 251	Combined sources	3
Helixⁱ	258 – 267	Combined sources	10
Turnⁱ	272 – 274	Combined sources	3
Helixⁱ	278 – 281	Combined sources	4
Helixⁱ	285 – 288	Combined sources	4
Helixⁱ	292 – 295	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P06493
SMRⁱ	P06493
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	4 – 287	Protein kinasePROSITE-ProRule annotationAdd BLAST		284

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0594 Eukaryota ENOG410XPP3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144030
HOVERGENⁱ	HBG014652
InParanoidⁱ	P06493
KEGG Orthology (KO) More...KOⁱ	K02087
OMAⁱ	SMLIYDP
PhylomeDBⁱ	P06493
TreeFamⁱ	TF101021

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P06493-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDYTKIEKI GEGTYGVVYK GRHKTTGQVV AMKKIRLESE EEGVPSTAIR 
        60         70         80         90        100
EISLLKELRH PNIVSLQDVL MQDSRLYLIF EFLSMDLKKY LDSIPPGQYM 
       110        120        130        140        150
DSSLVKSYLY QILQGIVFCH SRRVLHRDLK PQNLLIDDKG TIKLADFGLA 
       160        170        180        190        200
RAFGIPIRVY THEVVTLWYR SPEVLLGSAR YSTPVDIWSI GTIFAELATK 
       210        220        230        240        250
KPLFHGDSEI DQLFRIFRAL GTPNNEVWPE VESLQDYKNT FPKWKPGSLA 
       260        270        280        290 
SHVKNLDENG LDLLSKMLIY DPAKRISGKM ALNHPYFNDL DNQIKKM

Length:297

Mass (Da):34,095

Last modified:May 31, 2011 - v3

Checksum:ⁱ942D79448EFE490A

GO

Isoform 2 (identifier: P06493-2) [UniParc]FASTA Add to basket

Also known as: CDC2deltaT

The sequence of this isoform differs from the canonical sequence as follows:
107-163: Missing.

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        10         20         30         40         50
MEDYTKIEKI GEGTYGVVYK GRHKTTGQVV AMKKIRLESE EEGVPSTAIR 
        60         70         80         90        100
EISLLKELRH PNIVSLQDVL MQDSRLYLIF EFLSMDLKKY LDSIPPGQYM 
       110        120        130        140        150
DSSLVKVVTL WYRSPEVLLG SARYSTPVDI WSIGTIFAEL ATKKPLFHGD 
       160        170        180        190        200
SEIDQLFRIF RALGTPNNEV WPEVESLQDY KNTFPKWKPG SLASHVKNLD 
       210        220        230        240
ENGLDLLSKM LIYDPAKRIS GKMALNHPYF NDLDNQIKKM

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Length:240

Mass (Da):27,503

Checksum:ⁱ50FC3D192024E38C

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A024QZP7	A0A024QZP7_HUMAN	Cell division cycle 2, G1 to S and ... Cell division cycle 2, G1 to S and G2 to M, isoform CRA_a (Cyclin-dependent kinase 1)	CDK1 CDC2, hCG_40242	297	Annotation score:
E5RIU6	E5RIU6_HUMAN	Cyclin-dependent kinase 1 Cyclin-dependent kinase 1	CDK1	189	Annotation score:
A0A087WZZ9	A0A087WZZ9_HUMAN	Cyclin-dependent kinase 1 Cyclin-dependent kinase 1	CDK1	224	Annotation score:

Sequence cautionⁱ

The sequence EAW54204 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_021375	107 – 163	Missing in isoform 2. 1 PublicationAdd BLAST		57

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X05360 mRNA Translation: CAA28963.1 Y00272 mRNA Translation: CAA68376.1 D88357 mRNA Translation: BAA26001.1 AK291939 mRNA Translation: BAF84628.1 BT007004 mRNA Translation: AAP35650.1 AF512554 Genomic DNA Translation: AAM34793.1 AC022390 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54204.1 Sequence problems. BC014563 mRNA Translation: AAH14563.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44408.1 [P06493-1] CCDS7260.1 [P06493-2]
PIRⁱ	A29539
NCBI Reference Sequences More...RefSeqⁱ	NP_001307847.1, NM_001320918.1 [P06493-1] NP_001777.1, NM_001786.4 [P06493-1] NP_203698.1, NM_033379.4 [P06493-2] XP_005270360.1, XM_005270303.3 [P06493-1]
UniGeneⁱ	Hs.732435

Genome annotation databases

Ensemblⁱ	ENST00000316629; ENSP00000325970; ENSG00000170312 [P06493-2] ENST00000373809; ENSP00000362915; ENSG00000170312 [P06493-2] ENST00000395284; ENSP00000378699; ENSG00000170312 [P06493-1]
GeneIDⁱ	983
KEGGⁱ	hsa:983
UCSC genome browser More...UCSCⁱ	uc001jld.3 human [P06493-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P06493	CDK1 isoform 1		PANTR		297	UniRef100_P06493
CDK1 isoform 3		PONAB		297
Uncharacterized protein		PANPA		297
Cyclin dependent kinase 1		GORGO		297
Cyclin-dependent kinase 1 (Fragment)		HUMAN		189
+4
P06493-2	Cell division cycle 2, G1 to S and G2 to M, isoform CRA_c		HUMAN		240	UniRef100_A0A024QZJ8
CDK1 isoform 2		PANTR		240
CDK1 isoform 4		PONAB		240
Cyclin dependent kinase 1		GORGO		240

Protein	Similar proteins		Species	Score	Length	Source
P06493	Cyclin-dependent kinase 1		MOUSE		297	UniRef90_P06493
Cyclin-dependent kinase 1		PONAB		297
Cyclin-dependent kinase 1		RAT		297
Cyclin-dependent kinase 1		BOVIN		297
CDK1 isoform 1		PANTR		297
+121
P06493-2	Cell division cycle 2, G1 to S and G2 to M, isoform CRA_c		HUMAN		240	UniRef90_A0A024QZJ8
CDK1 isoform 2		PANTR		240
CDK1 isoform 4		PONAB		240
Cyclin dependent kinase 1		GORGO		240
cyclin-dependent kinase 1-like isoform X2		LEPWE		245
+25

Protein	Similar proteins		Species	Score	Length	Source
P06493	Cyclin-dependent kinase 1		BOVIN		297	UniRef50_P06493
Cyclin-dependent kinase 1		PONAB		297
Cyclin-dependent kinase 1		RAT		297
Cyclin-dependent kinase 1		MOUSE		297
Cyclin-dependent kinase 1		ORYJA		303
+282
P06493-2	Uncharacterized protein		FELCA		238	UniRef50_M3WJU6
cyclin-dependent kinase 2 isoform X5		ODORO		238
cyclin-dependent kinase 2 isoform X6		Enhydra lutris kenyoni		238
cyclin-dependent kinase 2 isoform X4		LIPVE		238
cyclin-dependent kinase 2		ERIEU		243
+168

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X05360 mRNA Translation: CAA28963.1 Y00272 mRNA Translation: CAA68376.1 D88357 mRNA Translation: BAA26001.1 AK291939 mRNA Translation: BAF84628.1 BT007004 mRNA Translation: AAP35650.1 AF512554 Genomic DNA Translation: AAM34793.1 AC022390 Genomic DNA No translation available. CH471083 Genomic DNA Translation: EAW54204.1 Sequence problems. BC014563 mRNA Translation: AAH14563.1
CCDSⁱ	CCDS44408.1 [P06493-1] CCDS7260.1 [P06493-2]
PIRⁱ	A29539
RefSeqⁱ	NP_001307847.1, NM_001320918.1 [P06493-1] NP_001777.1, NM_001786.4 [P06493-1] NP_203698.1, NM_033379.4 [P06493-2] XP_005270360.1, XM_005270303.3 [P06493-1]
UniGeneⁱ	Hs.732435

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1LC9	model	-	A	1-297	[»]
	4Y72	X-ray	2.30	A	1-297	[»]
	4YC3	X-ray	2.70	A	1-297	[»]
	4YC6	X-ray	2.60	A/C/E/G	1-297	[»]
	5HQ0	X-ray	2.30	A	1-297	[»]
	5LQF	X-ray	2.06	A/D	1-297	[»]
ProteinModelPortalⁱ	P06493
SMRⁱ	P06493
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107420, 275 interactors
ComplexPortalⁱ	CPX-2003 Cyclin A1-CDK1 complex CPX-2004 Cyclin A2-CDK1 complex CPX-2007 Cyclin B1-CDK1 complex CPX-2008 Cyclin B2-CDK1 complex
CORUMⁱ	P06493
DIPⁱ	DIP-35N
ELMⁱ	P06493
IntActⁱ	P06493, 129 interactors
MINTⁱ	P06493
STRINGⁱ	9606.ENSP00000378699

Chemistry databases

BindingDBⁱ	P06493
ChEMBLⁱ	CHEMBL308
DrugBankⁱ	DB04014 Alsterpaullone DB05037 AT7519 DB03496 Flavopiridol DB02950 Hymenialdisine DB02052 Indirubin-3'-Monoxime DB02116 Olomoucine DB03428 SU9516
GuidetoPHARMACOLOGYⁱ	1961

Protein family/group databases

TCDBⁱ	1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

TCDBⁱ

1.I.1.1.3 the eukaryotic nuclear pore complex (e-npc) family

PTM databases

iPTMnetⁱ	P06493
PhosphoSitePlusⁱ	P06493
SwissPalmⁱ	P06493

Polymorphism and mutation databases

BioMutaⁱ	CDK1
DMDMⁱ	334302921

2D gel databases

SWISS-2DPAGEⁱ	P06493

SWISS-2DPAGEⁱ

P06493

Proteomic databases

EPDⁱ	P06493
MaxQBⁱ	P06493
PaxDbⁱ	P06493
PeptideAtlasⁱ	P06493
PRIDEⁱ	P06493
ProteomicsDBⁱ	51905 51906 [P06493-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	983
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000316629; ENSP00000325970; ENSG00000170312 [P06493-2] ENST00000373809; ENSP00000362915; ENSG00000170312 [P06493-2] ENST00000395284; ENSP00000378699; ENSG00000170312 [P06493-1]
GeneIDⁱ	983
KEGGⁱ	hsa:983
UCSCⁱ	uc001jld.3 human [P06493-1]

Organism-specific databases

CTDⁱ	983
DisGeNETⁱ	983
EuPathDBⁱ	HostDB:ENSG00000170312.15
GeneCardsⁱ	CDK1
HGNCⁱ	HGNC:1722 CDK1
HPAⁱ	CAB003799 HPA003387
MIMⁱ	116940 gene
neXtProtⁱ	NX_P06493
OpenTargetsⁱ	ENSG00000170312
PharmGKBⁱ	PA99
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0594 Eukaryota ENOG410XPP3 LUCA
GeneTreeⁱ	ENSGT00910000144030
HOVERGENⁱ	HBG014652
InParanoidⁱ	P06493
KOⁱ	K02087
OMAⁱ	SMLIYDP
PhylomeDBⁱ	P06493
TreeFamⁱ	TF101021

Enzyme and pathway databases

BRENDAⁱ	2.7.11.22 2681
Reactomeⁱ	R-HSA-110056 MAPK3 (ERK1) activation R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-170145 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase R-HSA-176412 Phosphorylation of the APC/C R-HSA-176417 Phosphorylation of Emi1 R-HSA-2299718 Condensation of Prophase Chromosomes R-HSA-2465910 MASTL Facilitates Mitotic Progression R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2514853 Condensation of Prometaphase Chromosomes R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-380320 Recruitment of NuMA to mitotic centrosomes R-HSA-4419969 Depolymerisation of the Nuclear Lamina R-HSA-539107 Activation of E2F1 target genes at G1/S R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-5687128 MAPK6/MAPK4 signaling R-HSA-5689896 Ovarian tumor domain proteases R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-6804757 Regulation of TP53 Degradation R-HSA-68875 Mitotic Prophase R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition R-HSA-69478 G2/M DNA replication checkpoint R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854518 AURKA Activation by TPX2 R-HSA-8878166 Transcriptional regulation by RUNX2
SignaLinkⁱ	P06493
SIGNORⁱ	P06493

Miscellaneous databases

ChiTaRSⁱ	CDK1 human
GeneWikiⁱ	Cdk1 Cyclin-dependent_kinase_1
GenomeRNAiⁱ	983
Protein Ontology More...PROⁱ	PR:P06493
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000170312 Expressed in 172 organ(s), highest expression level in intestine
CleanExⁱ	HS_CDC2
ExpressionAtlasⁱ	P06493 baseline and differential
Genevisibleⁱ	P06493 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CDK1_HUMAN
Accessionⁱ	P06493Primary (citable) accession number: P06493 Secondary accession number(s): A8K7C4, C9J497, O60764
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
	Last sequence update:	May 31, 2011
	Last modified:	November 7, 2018
	This is version 237 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - P06493 (CDK1_HUMAN)

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Cyclin-dependent kinase 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Mitochondrion

Nucleus

Other locations

Cytoskeleton

Cytosol

Endoplasmic reticulum

Extracellular region or secreted

Mitochondrion

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ