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UniProtKB - P06491 (MCP_HHV11)

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Protein

Major capsid protein

Gene

MCP

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Self-assembles to form an icosahedral capsid with a T=16 symmetry, about 200 nm in diameter, and consisting of 150 hexons and 12 pentons (total of 162 capsomers). Hexons form the edges and faces of the capsid and are each composed of six MCP molecules. In contrast, one penton is found at each of the 12 vertices. Eleven of the pentons are MCP pentamers, while the last vertex is occupied by the portal complex. The capsid is surrounded by a layer of proteinaceous material designated the tegument which, in turn, is enclosed in an envelope of host cell-derived lipids containing virus-encoded glycoproteins.UniRule annotation1 Publication

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Names & Taxonomyi

Protein namesi
Recommended name:
Major capsid proteinUniRule annotation
Short name:
MCPUniRule annotation
Gene namesi
Name:MCPUniRule annotation
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiViruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus ›
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome

Subcellular locationi

  • Virion UniRule annotation1 Publication
  • Host nucleus UniRule annotation1 Publication

GO - Cellular componenti

View the complete GO annotation on QuickGO ...

Keywords - Cellular componenti

Capsid protein, Host nucleus, T=16 icosahedral capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001157021 – 1374Major capsid proteinAdd BLAST1374

Proteomic databases

PRIDEiP06491

Interactioni

Subunit structurei

Homomultimer. Makes the hexons and eleven out of twelve pentons. Interacts with triplex proteins 1/TRX1 and 2/TRX2; adjacent capsomers are linked together in groups of three by triplexes, heterotrimeric complexes composed of one molecule of TRX1 and two molecules of TRX2. Interacts with scaffold protein; this interaction allows efficient MCP transport to the host nucleus. Interacts with capsid vertex component 2/CVC2. Interacts with the small capsomere-interacting protein/SCP.UniRule annotation4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
UL26P102103EBI-7608705,EBI-8621986

Protein-protein interaction databases

BioGridi971410, 1 interactor
DIPiDIP-57212N
IntActiP06491, 4 interactors
MINTiP06491

Structurei

Secondary structure

11374
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi487 – 489Combined sources3
Helixi498 – 506Combined sources9
Helixi510 – 514Combined sources5
Beta strandi548 – 550Combined sources3
Beta strandi572 – 574Combined sources3
Helixi579 – 581Combined sources3
Turni584 – 586Combined sources3
Helixi589 – 600Combined sources12
Helixi608 – 619Combined sources12
Helixi626 – 633Combined sources8
Helixi638 – 643Combined sources6
Helixi645 – 658Combined sources14
Helixi668 – 676Combined sources9
Helixi679 – 681Combined sources3
Helixi684 – 706Combined sources23
Helixi714 – 716Combined sources3
Helixi719 – 723Combined sources5
Beta strandi737 – 739Combined sources3
Helixi740 – 746Combined sources7
Turni750 – 752Combined sources3
Beta strandi764 – 767Combined sources4
Beta strandi771 – 773Combined sources3
Beta strandi782 – 784Combined sources3
Beta strandi789 – 793Combined sources5
Beta strandi796 – 798Combined sources3
Helixi803 – 814Combined sources12
Helixi816 – 821Combined sources6
Beta strandi826 – 830Combined sources5
Helixi832 – 839Combined sources8
Turni857 – 859Combined sources3
Helixi867 – 869Combined sources3
Helixi875 – 881Combined sources7
Helixi888 – 892Combined sources5
Helixi893 – 898Combined sources6
Beta strandi907 – 912Combined sources6
Beta strandi928 – 939Combined sources12
Turni948 – 952Combined sources5
Beta strandi953 – 957Combined sources5
Helixi967 – 971Combined sources5
Turni978 – 980Combined sources3
Helixi981 – 984Combined sources4
Helixi992 – 994Combined sources3
Helixi997 – 999Combined sources3
Beta strandi1000 – 1002Combined sources3
Helixi1004 – 1012Combined sources9
Helixi1017 – 1027Combined sources11
Helixi1033 – 1042Combined sources10

3D structure databases

ProteinModelPortaliP06491
SMRiP06491
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06491

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae major capsid protein family.UniRule annotation

Phylogenomic databases

OrthoDBiVOG0900000D

Family and domain databases

HAMAPiMF_04016 HSV_MCP, 1 hit
InterProiView protein in InterPro
IPR000912 Herpes_MCP
IPR023233 Herpes_MCP_upper_sf
PfamiView protein in Pfam
PF03122 Herpes_MCP, 1 hit
PRINTSiPR00235 HSVCAPSIDMCP
SUPFAMiSSF103417 SSF103417, 1 hit

Sequencei

Sequence statusi: Complete.

P06491-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPNRDPPG YRYAAAMVPT GSLLSTIEVA SHRRLFDFFS RVRSDANSLY 
        60         70         80         90        100
DVEFDALLGS YCNTLSLVRF LELGLSVACV CTKFPELAYM NEGRVQFEVH 
       110        120        130        140        150
QPLIARDGPH PIEQPTHNYM TKIIDRRALN AAFSLATEAI ALLTGEALDG 
       160        170        180        190        200
TGIGAHRQLR AIQQLARNVQ AVLGAFERGT ADQMLHVLLE KAPPLALLLP 
       210        220        230        240        250
MQRYLDNGRL ATRVARATLV AELKRSFCET SFFLGKAGHR REAVEAWLVD 
       260        270        280        290        300
LTTATQPSVA VPRLTHADTR GRPVDGVLVT TAPIKQRLLQ SFLKVEDTEA 
       310        320        330        340        350
DVPVTYGEMV LNGANLVTAL VMGKAVRSLD DVGRHLLEMQ EEQLDLNRQT 
       360        370        380        390        400
LDELESAPQT TRVRADLVSI GEKLVFLEAL EKRIYAATNV PYPLVGAMDL 
       410        420        430        440        450
TFVLPLGLFN PVMERFAAHA GDLVPAPGHP DPRAFPPRQL FFWGKDRQVL 
       460        470        480        490        500
RLSLEHAIGT VCHPSLMNVD AAVGGLNRDP VEAANPYGAY VAAPAGPAAD 
       510        520        530        540        550
MQQLFLNAWG QRLAHGRVRW VAEGQMTPEQ FMQPDNANLA LELHPAFDFF 
       560        570        580        590        600
VGVADVELPG GDVPPAGPGE IQATWRVVNG NLPLALCPAA FRDARGLELG 
       610        620        630        640        650
VGRHAMAPAT IAAVRGAFDD RNYPAVFYLL QAAIHGSEHV FCALARLVVQ 
       660        670        680        690        700
CITSYWNNTR CAAFVNDYSL VSYVVTYLGG DLPEECMAVY RDLVAHVEAL 
       710        720        730        740        750
AQLVDDFTLT GPELGGQAQA ELNHLMRDPA LLPPLVWDCD ALMRRAALDR 
       760        770        780        790        800
HRDCRVSAGG HDPVYAAACN VATADFNRND GQLLHNTQAR AADAADDRPH 
       810        820        830        840        850
RGADWTVHHK IYYYVMVPAF SRGRCCTAGV RFDRVYATLQ NMVVPEIAPG 
       860        870        880        890        900
EECPSDPVTD PAHPLHPANL VANTVNAMFH NGRVVVDGPA MLTLQVLAHN 
       910        920        930        940        950
MAERTTALLC SAAPDAGANT ASTTNMRIFD GALHAGILLM APQHLDHTIQ 
       960        970        980        990       1000
NGDYFYPLPV HALFAGADHV ANAPNFPPAL RDLSRQVPLV PPALGANYFS 
      1010       1020       1030       1040       1050
SIRQPVVQHV RESAAGENAL TYALMAGYFK ISPVALHHQL KTGLHPGFGF 
      1060       1070       1080       1090       1100
TVVRQDRFVT ENVLFSERAS EAYFLGQLQV ARHETGGGVN FTLTQPRANV 
      1110       1120       1130       1140       1150
DLGVGYTAVV ATATVRNPVT DMGNLPQNFY LGRGAPPLLD NAAAVYLRNA 
      1160       1170       1180       1190       1200
VVAGNRLGPA QPVPVFGCAQ VPRRAGMDHG QDAVCEFIAT PVSTDVNYFR 
      1210       1220       1230       1240       1250
RPCNPRGRAA GGVYAGDKEG DVTALMYDHG QSDPSRAFAA TANPWASQRF 
      1260       1270       1280       1290       1300
SYGDLLYNGA YHLNGASPVL SPCFKFFTSA DIAAKHRCLE RLIVETGSAV 
      1310       1320       1330       1340       1350
STATAASDVQ FKRPPGCREL VEDPCGLFQE AYPLTCASDP ALLRSARNGE 
      1360       1370 
AHARETHFAQ YLVYDASPLK GLAL
Length:1,374
Mass (Da):149,084
Last modified:January 1, 1988 - v1
Checksum:i859C76E2EADE05B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32332.1
X04467 Genomic DNA Translation: CAA28154.1
PIRiA27239 VCBE17

Similar proteinsi

Entry informationi

Entry nameiMCP_HHV11
AccessioniPrimary (citable) accession number: P06491
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: February 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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