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Protein

Envelope glycoprotein I

Gene

gI

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In epithelial cells, the heterodimer gE/gI is required for the cell-to-cell spread of the virus, by sorting nascent virions to cell junctions. Once the virus reaches the cell junctions, virus particles can spread to adjacent cells extremely rapidly through interactions with cellular receptors that accumulate at these junctions. Implicated in basolateral spread in polarized cells. In neuronal cells, gE/gI is essential for the anterograde spread of the infection throughout the host nervous system. Together with US9, the heterodimer gE/gI is involved in the sorting and transport of viral structural components toward axon tips.3 Publications
The heterodimer gE/gI serves as a receptor for the Fc part of human IgG. Dissociation of gE/gI from IgG occurs at acidic pH. May thus be involved in anti-HSV antibodies bipolar bridging, followed by intracellular endocytosis and degradation, thereby interfering with host Ig-mediated immune responses.

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein I
Short name:
gI
Gene namesi
Name:gI
ORF Names:US7
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome
  • UP000180652 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 276Virion surfaceSequence analysisAdd BLAST256
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Topological domaini298 – 390IntravirionSequence analysisAdd BLAST93

GO - Cellular componenti

Keywords - Cellular componenti

Host cell junction, Host cell membrane, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2364696

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000011577021 – 390Envelope glycoprotein IAdd BLAST370

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi156N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi175N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi257N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP06487

Interactioni

Subunit structurei

Interacts with gE; this interaction enhances the Fc receptor function of gE.By similarity

Structurei

3D structure databases

ProteinModelPortaliP06487
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG090000E2

Family and domain databases

InterProiView protein in InterPro
IPR002874 Herpes_gI
PfamiView protein in Pfam
PF01688 Herpes_gI, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06487-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPCRPLQGLV LVGLWVCATS LVVRGPTVSL VSNSFVDAGA LGPDGVVEED
60 70 80 90 100
LLILGELRFV GDQVPHTTYY DGGVELWHYP MGHKCPRVVH VVTVTACPRR
110 120 130 140 150
PAVAFALCRA TDSTHSPAYP TLELNLAQQP LLRVQRATRD YAGVYVLRVW
160 170 180 190 200
VGDAPNASLF VLGMAIAAEG TLAYNGSAYG SCDPKLLPSS APRLAPASVY
210 220 230 240 250
QPAPNQASTP STTTSTPSTT IPAPSTTIPA PQASTTPFPT GDPKPQPPGV
260 270 280 290 300
NHEPPSNATR ATRDSRYALT VTQIIQIAIP ASIIALVFLG SCICFIHRCQ
310 320 330 340 350
RRYRRSRRPI YSPQMPTGIS CAVNEAAMAR LGAELKSHPS TPPKSRRRSS
360 370 380 390
RTPMPSLTAI AEESEPAGAA GLPTPPVDPT TPTPTPPLLV
Length:390
Mass (Da):41,370
Last modified:January 1, 1988 - v1
Checksum:i39381B1D6B5F08C8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti73G → V in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti165A → T in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti225 – 231Missing in strain: Nonneuroinvasive mutant HF10. 7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32284.1
X02138 Genomic DNA Translation: CAA26061.1
L00036 Genomic DNA Translation: AAA96681.1
DQ889502 Genomic DNA Translation: ABI63525.1
FJ593289 Genomic DNA Translation: ACM62296.1
PIRiA05243 QQBE77
RefSeqiYP_009137142.1, NC_001806.2

Genome annotation databases

GeneIDi2703446
KEGGivg:2703446

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14112 Genomic DNA Translation: CAA32284.1
X02138 Genomic DNA Translation: CAA26061.1
L00036 Genomic DNA Translation: AAA96681.1
DQ889502 Genomic DNA Translation: ABI63525.1
FJ593289 Genomic DNA Translation: ACM62296.1
PIRiA05243 QQBE77
RefSeqiYP_009137142.1, NC_001806.2

3D structure databases

ProteinModelPortaliP06487
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL2364696

Proteomic databases

PRIDEiP06487

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703446
KEGGivg:2703446

Phylogenomic databases

OrthoDBiVOG090000E2

Miscellaneous databases

PROiPR:P06487

Family and domain databases

InterProiView protein in InterPro
IPR002874 Herpes_gI
PfamiView protein in Pfam
PF01688 Herpes_gI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGI_HHV11
AccessioniPrimary (citable) accession number: P06487
Secondary accession number(s): B9VQK1, Q09I70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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