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Protein

Protein US2

Gene

US2

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Biological processHost-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Protein US2
Gene namesi
ORF Names:US2
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome
  • UP000180652 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved; by host1 Publication
ChainiPRO_00001161262 – 291Protein US2Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycine; by host; partial1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP06485

Interactioni

Subunit structurei

Interacts with host KRT18.By similarity

Protein-protein interaction databases

BioGridi971433, 2 interactors

Structurei

3D structure databases

SMRiP06485
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 8Poly-Val6

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG090000NP

Family and domain databases

InterProiView protein in InterPro
IPR003485 Herpes_US2_varicellovirus
IPR036179 Ig-like_dom_sf
PfamiView protein in Pfam
PF02476 US2, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06485-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGVVVVNVMT LLDQNNALPR TSVDASPALW SFLLRQCRIL ASEPLGTPVV
60 70 80 90 100
VRPANLRRLA EPLMDLPKPT RPIVRTRSCR CPPNTTTGLF AEDSPLESTE
110 120 130 140 150
VVDAVACFRL LHRDQPSPPR LYHLWVVGAA DLCVPFLEYA QKIRLGVRFI
160 170 180 190 200
AIKTPDAWVG EPWAVPTRFL PEWTVAWTPF PAAPNHPLET LLSRYEYQYG
210 220 230 240 250
VVLPGTNGRE RDCMRWLRSL IALHKPHPAT PGPLTTSHPV RRPCCACMGM
260 270 280 290
PEVPDEQPTS PGRGPQETDP LIAVRGERPR LPHICYPVTT L
Length:291
Mass (Da):32,471
Last modified:January 23, 2007 - v3
Checksum:i7227D9F051FD3A78
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti80R → C in strain: Nonneuroinvasive mutant HF10. 1
Natural varianti172E → K in strain: Nonneuroinvasive mutant HF10. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02138 Genomic DNA Translation: CAA26056.1
L00036 Genomic DNA Translation: AAA96686.1
X14112 Genomic DNA Translation: CAA32279.1
DQ889502 Genomic DNA Translation: ABI63520.1
FJ593289 Genomic DNA Translation: ACM62291.1
PIRiA05238 QQBE72
RefSeqiYP_009137137.1, NC_001806.2

Genome annotation databases

GeneIDi2703399
KEGGivg:2703399

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02138 Genomic DNA Translation: CAA26056.1
L00036 Genomic DNA Translation: AAA96686.1
X14112 Genomic DNA Translation: CAA32279.1
DQ889502 Genomic DNA Translation: ABI63520.1
FJ593289 Genomic DNA Translation: ACM62291.1
PIRiA05238 QQBE72
RefSeqiYP_009137137.1, NC_001806.2

3D structure databases

SMRiP06485
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971433, 2 interactors

Proteomic databases

PRIDEiP06485

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703399
KEGGivg:2703399

Phylogenomic databases

OrthoDBiVOG090000NP

Family and domain databases

InterProiView protein in InterPro
IPR003485 Herpes_US2_varicellovirus
IPR036179 Ig-like_dom_sf
PfamiView protein in Pfam
PF02476 US2, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUS02_HHV11
AccessioniPrimary (citable) accession number: P06485
Secondary accession number(s): B9VQJ6, Q09I75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 77 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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