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Protein

Envelope glycoprotein G

Gene

gG

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Chemokine-binding protein that inhibits neutrophils' chemotaxis.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein G
Short name:
gG
Alternative name(s):
gG-1
Gene namesi
Name:gG
ORF Names:US4
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome
  • UP000180652 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 189Virion surfaceSequence analysisAdd BLAST165
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 238IntravirionSequence analysisAdd BLAST28

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Viral envelope protein, Virion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2364696

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000011576725 – 238Envelope glycoprotein GAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi49N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

BioGridi971434, 32 interactors

Structurei

3D structure databases

ProteinModelPortaliP06484
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi79 – 85Poly-Glu7

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06484-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQGAMRAVV PIIPFLLVLV GVSGVPTNVS STTQPQLQTT GRPSHEAPNM
60 70 80 90 100
TQTGTTDSPT AISLTTPDHT PPMPSIGLEE EEEEEGAGDG EHLEGGDGTR
110 120 130 140 150
DTLPQSPGPA FPLAEDVEKD KPNRPVVPSP DPNNSPARPE TSRPKTPPTI
160 170 180 190 200
IGPLATRPTT RLTSKGRPLV PTPQHTPLFS FLTASPALDT LFVVSTVIHT
210 220 230
LSFLCIGAMA THLCGGWSRR GRRTHPSVRY VCLPSERG
Length:238
Mass (Da):25,239
Last modified:January 1, 1988 - v1
Checksum:iF7FDC2867E834B92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00036 Genomic DNA Translation: AAA96684.1
X14112 Genomic DNA Translation: CAA32281.1
X02138 Genomic DNA Translation: CAA26058.1
AF117122 Genomic DNA Translation: AAD33228.1
AY240789 Genomic DNA Translation: AAP39675.1
AY240790 Genomic DNA Translation: AAP39678.1
AY240791 Genomic DNA Translation: AAP39681.1
AY240794 Genomic DNA Translation: AAP39690.1
AY240801 Genomic DNA Translation: AAP39711.1
AY240811 Genomic DNA Translation: AAP39741.1
AY240820 Genomic DNA Translation: AAP39768.1
AY240823 Genomic DNA Translation: AAP39777.1
DQ889502 Genomic DNA Translation: ABI63522.1
FJ593289 Genomic DNA Translation: ACM62293.1
PIRiA05239 QQBE74
RefSeqiYP_009137139.1, NC_001806.2

Genome annotation databases

GeneIDi2703401
KEGGivg:2703404

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00036 Genomic DNA Translation: AAA96684.1
X14112 Genomic DNA Translation: CAA32281.1
X02138 Genomic DNA Translation: CAA26058.1
AF117122 Genomic DNA Translation: AAD33228.1
AY240789 Genomic DNA Translation: AAP39675.1
AY240790 Genomic DNA Translation: AAP39678.1
AY240791 Genomic DNA Translation: AAP39681.1
AY240794 Genomic DNA Translation: AAP39690.1
AY240801 Genomic DNA Translation: AAP39711.1
AY240811 Genomic DNA Translation: AAP39741.1
AY240820 Genomic DNA Translation: AAP39768.1
AY240823 Genomic DNA Translation: AAP39777.1
DQ889502 Genomic DNA Translation: ABI63522.1
FJ593289 Genomic DNA Translation: ACM62293.1
PIRiA05239 QQBE74
RefSeqiYP_009137139.1, NC_001806.2

3D structure databases

ProteinModelPortaliP06484
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971434, 32 interactors

Chemistry databases

ChEMBLiCHEMBL2364696

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703401
KEGGivg:2703404

Miscellaneous databases

PROiPR:P06484

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiGG_HHV11
AccessioniPrimary (citable) accession number: P06484
Secondary accession number(s): Q770H5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 7, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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