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Protein

Envelope protein US9

Gene

US9

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the anterograde spread of the infection throughout the host nervous system. Together with the gE/gI heterodimer, US9 is involved in the sorting and transport of viral structural components toward axon tips.2 Publications

GO - Biological processi

  • intracellular transport of virus Source: CACAO

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope protein US9
Alternative name(s):
10 kDa protein
Gene namesi
ORF Names:US9
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome
  • UP000180652 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 67IntravirionBy similarityAdd BLAST67
Transmembranei68 – 88Helical; Signal-anchor for type II membrane proteinBy similarityAdd BLAST21
Topological domaini89 – 90Virion surfaceBy similarity2

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001161321 – 90Envelope protein US9Add BLAST90

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34Phosphoserine; by host CK2Sequence analysis1
Modified residuei36Phosphoserine; by host CK2Sequence analysis1

Post-translational modificationi

Phosphorylated on serines within the acidic cluster, possibly by host CK2. Phosphorylation determines whether endocytosed viral US9 traffics to the trans-Golgi network or recycles to the cell membrane.Curated

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP06481

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni30 – 39Acidic10

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi21 – 24Internalization motifSequence analysis4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi56 – 63Arg-rich (basic)8

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR009278 Herpes_US9
PfamiView protein in Pfam
PF06072 Herpes_US9, 1 hit

Sequencei

Sequence statusi: Complete.

P06481-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSRLSDPNS SARSDMSVPL YPTASPVSVE AYYSESEDEA ANDFLVRMGR
60 70 80 90
QQSVLRRRRR RTRCVGMVIA CLLVAVLSGG FGALLMWLLR
Length:90
Mass (Da):10,027
Last modified:January 1, 1988 - v1
Checksum:iF4D4DC2608BB38F7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti29V → A in strain: Nonneuroinvasive mutant HF10. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00036 Genomic DNA Translation: AAA96679.1
X14112 Genomic DNA Translation: CAA32274.1
X02138 Genomic DNA Translation: CAA26063.1
DQ889502 Genomic DNA Translation: ABI63528.1
FJ593289 Genomic DNA Translation: ACM62299.1
PIRiA05241 QQBE79
RefSeqiYP_009137145.1, NC_001806.2

Genome annotation databases

GeneIDi2703452
KEGGivg:2703452

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00036 Genomic DNA Translation: AAA96679.1
X14112 Genomic DNA Translation: CAA32274.1
X02138 Genomic DNA Translation: CAA26063.1
DQ889502 Genomic DNA Translation: ABI63528.1
FJ593289 Genomic DNA Translation: ACM62299.1
PIRiA05241 QQBE79
RefSeqiYP_009137145.1, NC_001806.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP06481

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703452
KEGGivg:2703452

Family and domain databases

InterProiView protein in InterPro
IPR009278 Herpes_US9
PfamiView protein in Pfam
PF06072 Herpes_US9, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUS9_HHV11
AccessioniPrimary (citable) accession number: P06481
Secondary accession number(s): B9VQK4, Q09I67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: May 23, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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