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Protein

Envelope glycoprotein J

Gene

gJ

Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Inhibits host cell apoptosis. Induces an increase in reactive oxygen species (ROS) in the host cell.1 Publication

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein J
Gene namesi
Name:gJ
ORF Names:US5
OrganismiHuman herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifieri10299 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeAlphaherpesvirinaeSimplexvirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000009294 Componenti: Genome
  • UP000180652 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 49ExtracellularSequence analysisAdd BLAST28
Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 92CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Host endoplasmic reticulum, Host endosome, Host Golgi apparatus, Host membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2364696

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000011578922 – 92Envelope glycoprotein JAdd BLAST71

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi30N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP06480

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiView protein in InterPro
IPR004913 Herpes_gJ
PfamiView protein in Pfam
PF03229 Alpha_GJ, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P06480-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLRAVWHLG LLGSLVGAVL AATHRGPAAN TTDPLTHAPV SPHPSPLGGF
60 70 80 90
AVPLVVGGLC AVVLGAACLL ELLRRTCRGW GRYHPYMDPV VV
Length:92
Mass (Da):9,556
Last modified:January 1, 1988 - v1
Checksum:i14DA8BD9F18DA655
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00036 Genomic DNA Translation: AAA96683.1
X14112 Genomic DNA Translation: CAA32282.1
X02138 Genomic DNA Translation: CAA26059.1
AY240646 Genomic DNA Translation: AAP39247.1
AY240647 Genomic DNA Translation: AAP39250.1
AY240651 Genomic DNA Translation: AAP39262.1
AY240655 Genomic DNA Translation: AAP39274.1
AY240657 Genomic DNA Translation: AAP39280.1
AY240658 Genomic DNA Translation: AAP39283.1
AY240789 Genomic DNA Translation: AAP39676.1
AY240790 Genomic DNA Translation: AAP39679.1
AY240791 Genomic DNA Translation: AAP39682.1
AY240794 Genomic DNA Translation: AAP39691.1
AY240795 Genomic DNA Translation: AAP39694.1
AY240796 Genomic DNA Translation: AAP39697.1
AY240797 Genomic DNA Translation: AAP39700.1
AY240800 Genomic DNA Translation: AAP39709.1
AY240801 Genomic DNA Translation: AAP39712.1
AY240802 Genomic DNA Translation: AAP39715.1
AY240805 Genomic DNA Translation: AAP39724.1
AY240806 Genomic DNA Translation: AAP39727.1
AY240808 Genomic DNA Translation: AAP39733.1
AY240809 Genomic DNA Translation: AAP39736.1
AY240811 Genomic DNA Translation: AAP39742.1
AY240812 Genomic DNA Translation: AAP39745.1
AY240820 Genomic DNA Translation: AAP39769.1
AY240821 Genomic DNA Translation: AAP39772.1
AY240822 Genomic DNA Translation: AAP39775.1
DQ889502 Genomic DNA Translation: ABI63523.1
FJ593289 Genomic DNA Translation: ACM62294.1
PIRiA05240 QQBE75
RefSeqiYP_009137140.1, NC_001806.2

Genome annotation databases

GeneIDi2703406
KEGGivg:2703406

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00036 Genomic DNA Translation: AAA96683.1
X14112 Genomic DNA Translation: CAA32282.1
X02138 Genomic DNA Translation: CAA26059.1
AY240646 Genomic DNA Translation: AAP39247.1
AY240647 Genomic DNA Translation: AAP39250.1
AY240651 Genomic DNA Translation: AAP39262.1
AY240655 Genomic DNA Translation: AAP39274.1
AY240657 Genomic DNA Translation: AAP39280.1
AY240658 Genomic DNA Translation: AAP39283.1
AY240789 Genomic DNA Translation: AAP39676.1
AY240790 Genomic DNA Translation: AAP39679.1
AY240791 Genomic DNA Translation: AAP39682.1
AY240794 Genomic DNA Translation: AAP39691.1
AY240795 Genomic DNA Translation: AAP39694.1
AY240796 Genomic DNA Translation: AAP39697.1
AY240797 Genomic DNA Translation: AAP39700.1
AY240800 Genomic DNA Translation: AAP39709.1
AY240801 Genomic DNA Translation: AAP39712.1
AY240802 Genomic DNA Translation: AAP39715.1
AY240805 Genomic DNA Translation: AAP39724.1
AY240806 Genomic DNA Translation: AAP39727.1
AY240808 Genomic DNA Translation: AAP39733.1
AY240809 Genomic DNA Translation: AAP39736.1
AY240811 Genomic DNA Translation: AAP39742.1
AY240812 Genomic DNA Translation: AAP39745.1
AY240820 Genomic DNA Translation: AAP39769.1
AY240821 Genomic DNA Translation: AAP39772.1
AY240822 Genomic DNA Translation: AAP39775.1
DQ889502 Genomic DNA Translation: ABI63523.1
FJ593289 Genomic DNA Translation: ACM62294.1
PIRiA05240 QQBE75
RefSeqiYP_009137140.1, NC_001806.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

ChEMBLiCHEMBL2364696

Proteomic databases

PRIDEiP06480

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2703406
KEGGivg:2703406

Miscellaneous databases

PROiPR:P06480

Family and domain databases

InterProiView protein in InterPro
IPR004913 Herpes_gJ
PfamiView protein in Pfam
PF03229 Alpha_GJ, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGJ_HHV11
AccessioniPrimary (citable) accession number: P06480
Secondary accession number(s): Q771F7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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