gJ - Envelope glycoprotein J precursor - Human herpesvirus 1 (strain 17) (HHV-1)

Functionⁱ

Inhibits host cell apoptosis. Induces an increase in reactive oxygen species (ROS) in the host cell.1 Publication

GO - Biological processⁱ

suppression by virus of host apoptotic process Source: InterPro

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Envelope glycoprotein J
Gene namesⁱ	Name:gJ ORF Names:US5
Organismⁱ	Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifierⁱ	10299 [NCBI]
Taxonomic lineageⁱ	Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1
Virus hostⁱ	Homo sapiens (Human) [TaxID: 9606]
Proteomesⁱ	UP000009294 Componentⁱ: Genome UP000180652 Componentⁱ: Genome

Subcellular locationⁱ

Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated
Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
Host endosome membrane Curated; Single-pass type I membrane protein Curated

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	22 – 49	ExtracellularSequence analysisAdd BLAST	28
Transmembraneⁱ	50 – 70	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	71 – 92	CytoplasmicSequence analysisAdd BLAST	22

GO - Cellular componentⁱ

host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
host cell endosome membrane Source: UniProtKB-SubCell
host cell Golgi membrane Source: UniProtKB-SubCell
integral component of membrane Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Host endoplasmic reticulum, Host endosome, Host Golgi apparatus, Host membrane, Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL2364696

ChEMBLⁱ

CHEMBL2364696

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	Sequence analysisAdd BLAST		21
ChainⁱPRO_0000115789	22 – 92	Envelope glycoprotein JAdd BLAST		71

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	30	N-linked (GlcNAc...) asparagine; by hostSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PRIDEⁱ	P06480

PRIDEⁱ

P06480

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the alphaherpesvirinae glycoprotein J family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProⁱ	View protein in InterPro IPR004913 Herpes_gJ
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03229 Alpha_GJ, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P06480-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSLRAVWHLG LLGSLVGAVL AATHRGPAAN TTDPLTHAPV SPHPSPLGGF 
        60         70         80         90 
AVPLVVGGLC AVVLGAACLL ELLRRTCRGW GRYHPYMDPV VV

Length:92

Mass (Da):9,556

Last modified:January 1, 1988 - v1

Checksum:ⁱ14DA8BD9F18DA655

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L00036 Genomic DNA Translation: AAA96683.1 X14112 Genomic DNA Translation: CAA32282.1 X02138 Genomic DNA Translation: CAA26059.1 AY240646 Genomic DNA Translation: AAP39247.1 AY240647 Genomic DNA Translation: AAP39250.1 AY240651 Genomic DNA Translation: AAP39262.1 AY240655 Genomic DNA Translation: AAP39274.1 AY240657 Genomic DNA Translation: AAP39280.1 AY240658 Genomic DNA Translation: AAP39283.1 AY240789 Genomic DNA Translation: AAP39676.1 AY240790 Genomic DNA Translation: AAP39679.1 AY240791 Genomic DNA Translation: AAP39682.1 AY240794 Genomic DNA Translation: AAP39691.1 AY240795 Genomic DNA Translation: AAP39694.1 AY240796 Genomic DNA Translation: AAP39697.1 AY240797 Genomic DNA Translation: AAP39700.1 AY240800 Genomic DNA Translation: AAP39709.1 AY240801 Genomic DNA Translation: AAP39712.1 AY240802 Genomic DNA Translation: AAP39715.1 AY240805 Genomic DNA Translation: AAP39724.1 AY240806 Genomic DNA Translation: AAP39727.1 AY240808 Genomic DNA Translation: AAP39733.1 AY240809 Genomic DNA Translation: AAP39736.1 AY240811 Genomic DNA Translation: AAP39742.1 AY240812 Genomic DNA Translation: AAP39745.1 AY240820 Genomic DNA Translation: AAP39769.1 AY240821 Genomic DNA Translation: AAP39772.1 AY240822 Genomic DNA Translation: AAP39775.1 DQ889502 Genomic DNA Translation: ABI63523.1 FJ593289 Genomic DNA Translation: ACM62294.1
PIRⁱ	A05240 QQBE75
NCBI Reference Sequences More...RefSeqⁱ	YP_009137140.1, NC_001806.2

Genome annotation databases

GeneIDⁱ	2703406
KEGGⁱ	vg:2703406

Protein	Similar proteins		Species	Score	Length	Source
P06480	Envelope glycoprotein J		HHV1		92	UniRef100_P06480
Envelope glycoprotein J		Human alphaherpesvirus 1 strain RH2		92

Protein	Similar proteins		Species	Score	Length	Source
P06480	Envelope glycoprotein J		HHV1		92	UniRef90_P06480
Envelope glycoprotein J		Human alphaherpesvirus 1 strain RH2		92
Envelope glycoprotein J		HHV1		92
Envelope glycoprotein J		HHV1		92
Envelope glycoprotein J		HHV1		92
+26

Protein	Similar proteins		Species	Score	Length	Source
P06480	Envelope glycoprotein J		HHV1		92	UniRef50_P06480
Envelope glycoprotein J		Human alphaherpesvirus 1 strain RH2		92
US5		HHV1		92
US5		HHV1		92
US5		HHV1		92
+27

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L00036 Genomic DNA Translation: AAA96683.1 X14112 Genomic DNA Translation: CAA32282.1 X02138 Genomic DNA Translation: CAA26059.1 AY240646 Genomic DNA Translation: AAP39247.1 AY240647 Genomic DNA Translation: AAP39250.1 AY240651 Genomic DNA Translation: AAP39262.1 AY240655 Genomic DNA Translation: AAP39274.1 AY240657 Genomic DNA Translation: AAP39280.1 AY240658 Genomic DNA Translation: AAP39283.1 AY240789 Genomic DNA Translation: AAP39676.1 AY240790 Genomic DNA Translation: AAP39679.1 AY240791 Genomic DNA Translation: AAP39682.1 AY240794 Genomic DNA Translation: AAP39691.1 AY240795 Genomic DNA Translation: AAP39694.1 AY240796 Genomic DNA Translation: AAP39697.1 AY240797 Genomic DNA Translation: AAP39700.1 AY240800 Genomic DNA Translation: AAP39709.1 AY240801 Genomic DNA Translation: AAP39712.1 AY240802 Genomic DNA Translation: AAP39715.1 AY240805 Genomic DNA Translation: AAP39724.1 AY240806 Genomic DNA Translation: AAP39727.1 AY240808 Genomic DNA Translation: AAP39733.1 AY240809 Genomic DNA Translation: AAP39736.1 AY240811 Genomic DNA Translation: AAP39742.1 AY240812 Genomic DNA Translation: AAP39745.1 AY240820 Genomic DNA Translation: AAP39769.1 AY240821 Genomic DNA Translation: AAP39772.1 AY240822 Genomic DNA Translation: AAP39775.1 DQ889502 Genomic DNA Translation: ABI63523.1 FJ593289 Genomic DNA Translation: ACM62294.1
PIRⁱ	A05240 QQBE75
RefSeqⁱ	YP_009137140.1, NC_001806.2

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Chemistry databases

ChEMBLⁱ	CHEMBL2364696

ChEMBLⁱ

CHEMBL2364696

Proteomic databases

PRIDEⁱ	P06480

PRIDEⁱ

P06480

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	2703406
KEGGⁱ	vg:2703406

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P06480

PROⁱ

PR:P06480

Family and domain databases

InterProⁱ	View protein in InterPro IPR004913 Herpes_gJ
Pfamⁱ	View protein in Pfam PF03229 Alpha_GJ, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GJ_HHV11
Accessionⁱ	P06480Primary (citable) accession number: P06480 Secondary accession number(s): Q771F7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
	Last sequence update:	January 1, 1988
	Last modified:	May 23, 2018
	This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Viral Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P06480 (GJ_HHV11)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Envelope glycoprotein J

gJ

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Chemistry databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ