UniProtKB - P06477 (GH_HHV11)
Protein
Envelope glycoprotein H
Gene
gH
Organism
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Status
Functioni
The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis.UniRule annotation1 Publication
GO - Biological processi
- fusion of virus membrane with host plasma membrane Source: UniProtKB-UniRule
Keywordsi
Biological process | Fusion of virus membrane with host cell membrane, Fusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell |
Ligand | Sialic acid |
Protein family/group databases
TCDBi | 1.G.10.1.1, the herpes simplex virus membrane fusion complex (hsv-mfc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Envelope glycoprotein HUniRule annotationShort name: gHUniRule annotation |
Gene namesi | Name:gHUniRule annotation ORF Names:UL22 |
Organismi | Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) |
Taxonomic identifieri | 10299 [NCBI] |
Taxonomic lineagei | Viruses › Duplodnaviria › Heunggongvirae › Peploviricota › Herviviricetes › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Virion membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation
- Host cell membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation
- Host endosome membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation Note: During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).UniRule annotation
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 803 | Virion surfaceUniRule annotationAdd BLAST | 785 | |
Transmembranei | 804 – 824 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 825 – 838 | IntravirionUniRule annotationAdd BLAST | 14 |
GO - Cellular componenti
- host cell endosome membrane Source: UniProtKB-SubCell
- host cell plasma membrane Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-UniRule
- viral envelope Source: UniProtKB-UniRule
- virion membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Host cell membrane, Host endosome, Host membrane, Membrane, Viral envelope protein, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | UniRule annotationAdd BLAST | 18 | |
ChainiPRO_0000436656 | 19 – 838 | Envelope glycoprotein HUniRule annotationAdd BLAST | 820 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 73 | N-linked (GlcNAc...) asparagine; by hostUniRule annotation | 1 | |
Glycosylationi | 120 | N-linked (GlcNAc...) asparagine; by hostUniRule annotation | 1 | |
Glycosylationi | 216 | N-linked (GlcNAc...) asparagine; by hostUniRule annotation | 1 | |
Glycosylationi | 332 | N-linked (GlcNAc...) asparagine; by hostUniRule annotation | 1 | |
Glycosylationi | 437 | N-linked (GlcNAc...) asparagine; by hostUniRule annotation | 1 | |
Glycosylationi | 670 | N-linked (GlcNAc...) asparagine; by hostUniRule annotation | 1 | |
Glycosylationi | 784 | N-linked (GlcNAc...) asparagine; by hostUniRule annotation | 1 |
Post-translational modificationi
N-glycosylated, O-glycosylated, and sialylated.UniRule annotation1 Publication
Keywords - PTMi
GlycoproteinProteomic databases
PRIDEi | P06477 |
Interactioni
Subunit structurei
Interacts with glycoprotein L (gL); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion (By similarity). Associates with the gB-gH/gL-gD complex (Probable).
Interacts with VP16.
UniRule annotationCurated5 PublicationsProtein-protein interaction databases
BioGRIDi | 971414, 1 interactor |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P06477 |
SMRi | P06477 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 259 – 323 | Interaction with gLUniRule annotationAdd BLAST | 65 |
Sequence similaritiesi
Belongs to the herpesviridae glycoprotein H family.UniRule annotation
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixFamily and domain databases
Gene3Di | 2.60.40.3190, 1 hit |
HAMAPi | MF_04033, HSV_GH, 1 hit |
InterProi | View protein in InterPro IPR003493, Herpes_gH IPR035305, Herpes_glycoH_C IPR038172, Herpes_glycoH_C_sf |
Pfami | View protein in Pfam PF17488, Herpes_glycoH_C, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P06477-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGNGLWFVGV IILGVAWGQV HDWTEQTDPW FLDGLGMDRM YWRDTNTGRL
60 70 80 90 100
WLPNTPDPQK PPRGFLAPPD ELNLTTASLP LLRWYEERFC FVLVTTAEFP
110 120 130 140 150
RDPGQLLYIP KTYLLGRPPN ASLPAPTTVE PTAQPPPSVA PLKGLLHNPA
160 170 180 190 200
ASVLLRSRAW VTFSAVPDPE ALTFPRGDNV ATASHPSGPR DTPPPRPPVG
210 220 230 240 250
ARRHPTTELD ITHLHNASTT WLATRGLLRS PGRYVYFSPS ASTWPVGIWT
260 270 280 290 300
TGELVLGCDA ALVRARYGRE FMGLVISMHD SPPVEVMVVP AGQTLDRVGD
310 320 330 340 350
PADENPPGAL PGPPGGPRYR VFVLGSLTRA DNGSALDALR RVGGYPEEGT
360 370 380 390 400
NYAQFLSRAY AEFFSGDAGA EQGPRPPLFW RLTGLLATSG FAFVNAAHAN
410 420 430 440 450
GAVCLSDLLG FLAHSRALAG LAARGAAGCA ADSVFFNVSV LDPTARLQLE
460 470 480 490 500
ARLQHLVAEI LEREQSLALH ALGYQLAFVL DSPSAYDAVA PSAAHLIDAL
510 520 530 540 550
YAEFLGGRVL TTPVVHRALF YASAVLRQPF LAGVPSAVQR ERARRSLLIA
560 570 580 590 600
SALCTSDVAA ATNADLRTAL ARADHQKTLF WLPDHFSPCA ASLRFDLDES
610 620 630 640 650
VFILDALAQA TRSETPVEVL AQQTHGLAST LTRWAHYNAL IRAFVPEASH
660 670 680 690 700
RCGGQSANVE PRILVPITHN ASYVVTHSPL PRGIGYKLTG VDVRRPLFLT
710 720 730 740 750
YLTATCEGST RDIESKRLVR TQNQRDLGLV GAVFMRYTPA GEVMSVLLVD
760 770 780 790 800
TDNTQQQIAA GPTEGAPSVF SSDVPSTALL LFPNGTVIHL LAFDTQPVAA
810 820 830
IAPGFLAASA LGVVMITAAL AGILKVLRTS VPFFWRRE
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 15 | V → A in strain: Nonneuroinvasive mutant HF10. | 1 | |
Natural varianti | 138 | S → A in strain: Nonneuroinvasive mutant HF10. | 1 | |
Natural varianti | 150 | A → T in strain: Nonneuroinvasive mutant HF10. | 1 | |
Natural varianti | 284 | V → A in strain: Nonneuroinvasive mutant HF10. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03896 Genomic DNA Translation: CAA27534.1 X14112 Genomic DNA Translation: CAA32335.1 DQ889502 Genomic DNA Translation: ABI63484.1 FJ593289 Genomic DNA Translation: ACM62244.1 |
PIRi | A24018, VGBEG1 |
RefSeqi | YP_009137096.1, NC_001806.2 |
Genome annotation databases
GeneIDi | 24271466 |
KEGGi | vg:24271466 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03896 Genomic DNA Translation: CAA27534.1 X14112 Genomic DNA Translation: CAA32335.1 DQ889502 Genomic DNA Translation: ABI63484.1 FJ593289 Genomic DNA Translation: ACM62244.1 |
PIRi | A24018, VGBEG1 |
RefSeqi | YP_009137096.1, NC_001806.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2LQY | NMR | - | A | 625-644 | [»] | |
BMRBi | P06477 | |||||
SMRi | P06477 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 971414, 1 interactor |
Chemistry databases
ChEMBLi | CHEMBL2364696 |
DrugCentrali | P06477 |
Protein family/group databases
TCDBi | 1.G.10.1.1, the herpes simplex virus membrane fusion complex (hsv-mfc) family |
Proteomic databases
PRIDEi | P06477 |
Genome annotation databases
GeneIDi | 24271466 |
KEGGi | vg:24271466 |
Miscellaneous databases
PROi | PR:P06477 |
Family and domain databases
Gene3Di | 2.60.40.3190, 1 hit |
HAMAPi | MF_04033, HSV_GH, 1 hit |
InterProi | View protein in InterPro IPR003493, Herpes_gH IPR035305, Herpes_glycoH_C IPR038172, Herpes_glycoH_C_sf |
Pfami | View protein in Pfam PF17488, Herpes_glycoH_C, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GH_HHV11 | |
Accessioni | P06477Primary (citable) accession number: P06477 Secondary accession number(s): B9VQE9, Q09IB1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | January 1, 1988 | |
Last modified: | December 2, 2020 | |
This is version 103 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families