gH - Envelope glycoprotein H precursor - Human herpesvirus 1 (strain 17) (HHV-1)

Functionⁱ

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis.UniRule annotation1 Publication

GO - Biological processⁱ

fusion of virus membrane with host plasma membrane Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Fusion of virus membrane with host cell membrane, Fusion of virus membrane with host membrane, Viral penetration into host cytoplasm, Virus entry into host cell
Ligand	Sialic acid

Protein family/group databases

TCDBⁱ	1.G.10.1.1 the herpes simplex virus membrane fusion complex (hsv-mfc) family

TCDBⁱ

1.G.10.1.1 the herpes simplex virus membrane fusion complex (hsv-mfc) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Envelope glycoprotein HUniRule annotation Short name: gHUniRule annotation
Gene namesⁱ	Name:gHUniRule annotation ORF Names:UL22
Organismⁱ	Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifierⁱ	10299 [NCBI]
Taxonomic lineageⁱ	Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1
Virus hostⁱ	Homo sapiens (Human) [TaxID: 9606]
Proteomesⁱ	UP000009294 Componentⁱ: Genome UP000180652 Componentⁱ: Genome

Subcellular locationⁱ

Virion membrane
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_04033
; Single-pass type I membrane protein
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_04033
Host cell membrane
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_04033
; Single-pass type I membrane protein
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_04033
Host endosome membrane
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_04033
; Single-pass type I membrane protein
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_04033

Note:

During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. It is probably transported to the cell surface from where it is endocytosed and directed to the trans-Golgi network (TGN).UniRule annotation

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	19 – 803	Virion surfaceUniRule annotationAdd BLAST	785
Transmembraneⁱ	804 – 824	HelicalUniRule annotationAdd BLAST	21
Topological domainⁱ	825 – 838	IntravirionUniRule annotationAdd BLAST	14

GO - Cellular componentⁱ

host cell endosome membrane Source: UniProtKB-SubCell
host cell plasma membrane Source: UniProtKB-SubCell
integral component of membrane Source: UniProtKB-KW
viral envelope Source: UniProtKB-KW
virion membrane Source: UniProtKB-SubCell

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Host cell membrane, Host endosome, Host membrane, Membrane, Viral envelope protein, Virion

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL2364696

ChEMBLⁱ

CHEMBL2364696

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	UniRule annotationAdd BLAST		18
ChainⁱPRO_0000436656	19 – 838	Envelope glycoprotein HUniRule annotationAdd BLAST		820

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	73	N-linked (GlcNAc...) asparagine; by hostUniRule annotation	1
Glycosylationⁱ	120	N-linked (GlcNAc...) asparagine; by hostUniRule annotation	1
Glycosylationⁱ	216	N-linked (GlcNAc...) asparagine; by hostUniRule annotation	1
Glycosylationⁱ	332	N-linked (GlcNAc...) asparagine; by hostUniRule annotation	1
Glycosylationⁱ	437	N-linked (GlcNAc...) asparagine; by hostUniRule annotation	1
Glycosylationⁱ	670	N-linked (GlcNAc...) asparagine; by hostUniRule annotation	1
Glycosylationⁱ	784	N-linked (GlcNAc...) asparagine; by hostUniRule annotation	1

Post-translational modificationⁱ

N-glycosylated, O-glycosylated, and sialylated.UniRule annotation1 Publication

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

PRIDEⁱ	P06477

PRIDEⁱ

P06477

Interactionⁱ

Subunit structureⁱ

Interacts with glycoprotein L (gL); this interaction is necessary for the correct processing and cell surface expression of gH. The heterodimer gH/gL seems to interact with gB trimers during fusion (By similarity). Associates with the gB-gH/gL-gD complex (Probable). Interacts with VP16.UniRule annotationCurated5 Publications

Protein-protein interaction databases

BioGridⁱ	971414, 1 interactor

BioGridⁱ

971414, 1 interactor

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	627 – 633	Combined sources	7
Helixⁱ	634 – 636	Combined sources	3
Helixⁱ	638 – 641	Combined sources	4

3D structure databases

SMRⁱ	P06477
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	259 – 323	Interaction with gLUniRule annotationAdd BLAST		65

Sequence similaritiesⁱ

Belongs to the herpesviridae glycoprotein H family.UniRule annotation

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K19434
Database of Orthologous Groups More...OrthoDBⁱ	VOG0900001X

Family and domain databases

Gene3Dⁱ	2.60.40.3190, 1 hit
HAMAPⁱ	MF_04033 HSV_GH, 1 hit
InterProⁱ	View protein in InterPro IPR003493 Herpes_gH IPR035305 Herpes_glycoH_C IPR038172 Herpes_glycoH_C_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF17488 Herpes_glycoH_C, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P06477-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGNGLWFVGV IILGVAWGQV HDWTEQTDPW FLDGLGMDRM YWRDTNTGRL 
        60         70         80         90        100
WLPNTPDPQK PPRGFLAPPD ELNLTTASLP LLRWYEERFC FVLVTTAEFP 
       110        120        130        140        150
RDPGQLLYIP KTYLLGRPPN ASLPAPTTVE PTAQPPPSVA PLKGLLHNPA 
       160        170        180        190        200
ASVLLRSRAW VTFSAVPDPE ALTFPRGDNV ATASHPSGPR DTPPPRPPVG 
       210        220        230        240        250
ARRHPTTELD ITHLHNASTT WLATRGLLRS PGRYVYFSPS ASTWPVGIWT 
       260        270        280        290        300
TGELVLGCDA ALVRARYGRE FMGLVISMHD SPPVEVMVVP AGQTLDRVGD 
       310        320        330        340        350
PADENPPGAL PGPPGGPRYR VFVLGSLTRA DNGSALDALR RVGGYPEEGT 
       360        370        380        390        400
NYAQFLSRAY AEFFSGDAGA EQGPRPPLFW RLTGLLATSG FAFVNAAHAN 
       410        420        430        440        450
GAVCLSDLLG FLAHSRALAG LAARGAAGCA ADSVFFNVSV LDPTARLQLE 
       460        470        480        490        500
ARLQHLVAEI LEREQSLALH ALGYQLAFVL DSPSAYDAVA PSAAHLIDAL 
       510        520        530        540        550
YAEFLGGRVL TTPVVHRALF YASAVLRQPF LAGVPSAVQR ERARRSLLIA 
       560        570        580        590        600
SALCTSDVAA ATNADLRTAL ARADHQKTLF WLPDHFSPCA ASLRFDLDES 
       610        620        630        640        650
VFILDALAQA TRSETPVEVL AQQTHGLAST LTRWAHYNAL IRAFVPEASH 
       660        670        680        690        700
RCGGQSANVE PRILVPITHN ASYVVTHSPL PRGIGYKLTG VDVRRPLFLT 
       710        720        730        740        750
YLTATCEGST RDIESKRLVR TQNQRDLGLV GAVFMRYTPA GEVMSVLLVD 
       760        770        780        790        800
TDNTQQQIAA GPTEGAPSVF SSDVPSTALL LFPNGTVIHL LAFDTQPVAA 
       810        820        830 
IAPGFLAASA LGVVMITAAL AGILKVLRTS VPFFWRRE

Length:838

Mass (Da):90,366

Last modified:January 1, 1988 - v1

Checksum:ⁱ9AFDE1E690BD498F

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱ	15	V → A in strain: Nonneuroinvasive mutant HF10.	1
Natural variantⁱ	138	S → A in strain: Nonneuroinvasive mutant HF10.	1
Natural variantⁱ	150	A → T in strain: Nonneuroinvasive mutant HF10.	1
Natural variantⁱ	284	V → A in strain: Nonneuroinvasive mutant HF10.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X03896 Genomic DNA Translation: CAA27534.1 X14112 Genomic DNA Translation: CAA32335.1 DQ889502 Genomic DNA Translation: ABI63484.1 FJ593289 Genomic DNA Translation: ACM62244.1
PIRⁱ	A24018 VGBEG1
NCBI Reference Sequences More...RefSeqⁱ	YP_009137096.1, NC_001806.2

Genome annotation databases

GeneIDⁱ	24271466
KEGGⁱ	vg:24271466

Protein	Similar proteins		Species	Score	Length
P06477	Envelope glycoprotein H		HHV1		838
Envelope glycoprotein H		HHV11		104
Envelope glycoprotein H		HHV1E		838
Envelope glycoprotein H		HHV1F		838
Envelope glycoprotein H		Herpes simplex virus (type 1 /strain RH2)		838
+53

Protein	Similar proteins		Species	Score	Length
P06477	Envelope glycoprotein H		HHV1		838
Envelope glycoprotein H		HHV11		104
Envelope glycoprotein H		HHV1E		838
Envelope glycoprotein H		Herpes simplex virus (type 1 /strain RH2)		838
Envelope glycoprotein H		HHV1F		838
+93

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X03896 Genomic DNA Translation: CAA27534.1 X14112 Genomic DNA Translation: CAA32335.1 DQ889502 Genomic DNA Translation: ABI63484.1 FJ593289 Genomic DNA Translation: ACM62244.1
PIRⁱ	A24018 VGBEG1
NCBI Reference Sequences More...RefSeqⁱ	YP_009137096.1, NC_001806.2

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2LQY	NMR	-	A	625-644	[»]
SMRⁱ	P06477
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	971414, 1 interactor

BioGridⁱ

971414, 1 interactor

Chemistry databases

ChEMBLⁱ	CHEMBL2364696

ChEMBLⁱ

CHEMBL2364696

Protein family/group databases

TCDBⁱ	1.G.10.1.1 the herpes simplex virus membrane fusion complex (hsv-mfc) family

TCDBⁱ

1.G.10.1.1 the herpes simplex virus membrane fusion complex (hsv-mfc) family

Proteomic databases

PRIDEⁱ	P06477

PRIDEⁱ

P06477

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	24271466
KEGGⁱ	vg:24271466

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K19434
Database of Orthologous Groups More...OrthoDBⁱ	VOG0900001X

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P06477

PROⁱ

PR:P06477

Family and domain databases

Gene3Dⁱ	2.60.40.3190, 1 hit
HAMAPⁱ	MF_04033 HSV_GH, 1 hit
InterProⁱ	View protein in InterPro IPR003493 Herpes_gH IPR035305 Herpes_glycoH_C IPR038172 Herpes_glycoH_C_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF17488 Herpes_glycoH_C, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GH_HHV11
Accessionⁱ	P06477Primary (citable) accession number: P06477 Secondary accession number(s): B9VQE9, Q09IB1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
	Last sequence update:	January 1, 1988
	Last modified:	March 28, 2018
	This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Viral Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P06477 (GH_HHV11)

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Envelope glycoprotein H

gH

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ