RIR2

Functionⁱ

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells, as well as reactivation from latency in infected hosts. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.UniRule annotation

Catalytic activityⁱ

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H₂O = ribonucleoside diphosphate + thioredoxin.UniRule annotation

Cofactorⁱ

Fe cationUniRule annotation

Pathwayⁱ: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	94	Iron 1UniRule annotation	1
Metal bindingⁱ	124	Iron 1UniRule annotation	1
Metal bindingⁱ	124	Iron 2UniRule annotation	1
Metal bindingⁱ	127	Iron 1UniRule annotation	1
Active siteⁱ	131	UniRule annotation	1
Metal bindingⁱ	187	Iron 2UniRule annotation	1
Metal bindingⁱ	221	Iron 2UniRule annotation	1
Metal bindingⁱ	224	Iron 2UniRule annotation	1

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-UniRule
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

deoxyribonucleoside diphosphate metabolic process Source: UniProtKB-UniRule
deoxyribonucleotide biosynthetic process Source: InterPro
DNA replication Source: UniProtKB-UniRule
release from viral latency Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Biological process	DNA replication, Viral latency, Viral reactivation from latency
Ligand	Iron, Metal-binding

Enzyme and pathway databases

UniPathwayⁱ	UPA00326

UniPathwayⁱ

UPA00326

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ribonucleoside-diphosphate reductase small subunitUniRule annotation (EC:1.17.4.1UniRule annotation) Alternative name(s): Ribonucleotide reductase small subunitUniRule annotation
Gene namesⁱ	Name:RIR2UniRule annotation Synonyms:UL40
Organismⁱ	Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
Taxonomic identifierⁱ	10306 [NCBI]
Taxonomic lineageⁱ	Viruses › dsDNA viruses, no RNA stage › Herpesvirales › Herpesviridae › Alphaherpesvirinae › Simplexvirus › Human herpesvirus 1
Virus hostⁱ	Homo sapiens (Human) [TaxID: 9606]

Subcellular locationⁱ

Host membrane
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_04028
; Single-pass membrane protein
UniRule annotation
Manual assertion according to rulesⁱ
- HAMAP-Rule:MF_04028

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	180 – 200	HelicalUniRule annotationAdd BLAST		21

GO - Cellular componentⁱ

host cell membrane Source: UniProtKB-SubCell
integral component of membrane Source: UniProtKB-UniRule

View the complete GO annotation on QuickGO ...

Keywords - Cellular componentⁱ

Host membrane, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000190504	1 – 340	Ribonucleoside-diphosphate reductase small subunitAdd BLAST		340

Proteomic databases

PRIDEⁱ	P06474

PRIDEⁱ

P06474

Interactionⁱ

Subunit structureⁱ

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n.UniRule annotation

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P06474
SMRⁱ	P06474
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ribonucleoside diphosphate reductase small chain family.UniRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd01049 RNRR2, 1 hit
Gene3Dⁱ	1.10.620.20, 1 hit
HAMAPⁱ	MF_04028 HSV_RIR2, 1 hit
InterProⁱ	View protein in InterPro IPR009078 Ferritin-like_SF IPR034715 HSV_RIR2 IPR012348 RNR-like IPR033909 RNR_small IPR030475 RNR_small_AS IPR000358 RNR_small_fam
PANTHERⁱ	PTHR23409 PTHR23409, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00268 Ribonuc_red_sm, 1 hit
SUPFAMⁱ	SSF47240 SSF47240, 1 hit
PROSITEⁱ	View protein in PROSITE PS00368 RIBORED_SMALL, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P06474-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDSAAPALSP ALTAHTGHSA TADLAIQIPK CPDPERYFYT SQCPDINHLR 
        60         70         80         90        100
SLSILNRWLE TELVFVGDEE DVSKLSEGEL SFYRFLFAFL SAADDLVTEN 
       110        120        130        140        150
LGGLSGLFEQ KDILHYYVEQ ECIEVAHSRV YNIIQLVLFH NNDQARREYV 
       160        170        180        190        200
AGTINHPAIR AKVDWLEARV RECASVPEKF ILMILIEGIF FAASFAAIAY 
       210        220        230        240        250
LRTNNLLRVT CQSNDLISRD EAVHTTASCY IYNNYLGGHA KPPPDRVYGL 
       260        270        280        290        300
FRQAVEIEIG FIRSQAPTDS HILSPAALAA IENYVRFSAD RLLGLIHMKP 
       310        320        330        340
LFSAPPPDAS FPLSLMSTDK HTNFFECRST SYAGAVVNDL

Length:340

Mass (Da):37,966

Last modified:November 1, 1995 - v2

Checksum:ⁱ921DC04B9D278DE5

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J02212 Genomic DNA Translation: AAA66436.1

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

J02212 Genomic DNA Translation: AAA66436.1

Protein	Similar proteins		Species	Score	Length	Source
P06474	Ribonucleoside-diphosphate reductase small subunit		HHV11		340	UniRef90_P06474
Ribonucleoside-diphosphate reductase small subunit		HHV1		341
Ribonucleoside-diphosphate reductase small subunit		Human alphaherpesvirus 1 strain RH2		340
UL40 (Fragment)		HHV1		307
UL40 (Fragment)		HHV1		307
+227

Protein	Similar proteins		Species	Score	Length	Source
P06474	Ribonucleoside-diphosphate reductase small subunit		EHV1B		321	UniRef50_P28847
Ribonucleoside-diphosphate reductase small subunit		GAHVM		343
Ribonucleoside-diphosphate reductase small subunit		HHV11		340
Ribonucleoside-diphosphate reductase small subunit		HHV2H		337
Ribonucleoside-diphosphate reductase small subunit		HHV23		337
+308

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J02212 Genomic DNA Translation: AAA66436.1

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

J02212 Genomic DNA Translation: AAA66436.1

3D structure databases

ProteinModelPortalⁱ	P06474
SMRⁱ	P06474
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	P06474

PRIDEⁱ

P06474

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Enzyme and pathway databases

UniPathwayⁱ	UPA00326

UniPathwayⁱ

UPA00326

Family and domain databases

CDDⁱ	cd01049 RNRR2, 1 hit
Gene3Dⁱ	1.10.620.20, 1 hit
HAMAPⁱ	MF_04028 HSV_RIR2, 1 hit
InterProⁱ	View protein in InterPro IPR009078 Ferritin-like_SF IPR034715 HSV_RIR2 IPR012348 RNR-like IPR033909 RNR_small IPR030475 RNR_small_AS IPR000358 RNR_small_fam
PANTHERⁱ	PTHR23409 PTHR23409, 1 hit
Pfamⁱ	View protein in Pfam PF00268 Ribonuc_red_sm, 1 hit
SUPFAMⁱ	SSF47240 SSF47240, 1 hit
PROSITEⁱ	View protein in PROSITE PS00368 RIBORED_SMALL, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RIR2_HHV1K
Accessionⁱ	P06474Primary (citable) accession number: P06474
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
	Last sequence update:	November 1, 1995
	Last modified:	October 10, 2018
	This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Viral Protein Annotation Program

Miscellaneousⁱ

Documents

SIMILARITY comments
Index of protein domains and families
PATHWAY comments
Index of metabolic and biosynthesis pathways

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P06474 (RIR2_HHV1K)

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Ribonucleoside-diphosphate reductase small subunit

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: DNA replication

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

GO - Cellular componenti

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Family and domain databases

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

Pathwayⁱ: DNA replication

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ