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Protein

Hemoglobin subunit zeta

Gene

Hbz

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi59Iron (heme distal ligand)1
Metal bindingi88Iron (heme proximal ligand)1

GO - Molecular functioni

  • heme binding Source: GO_Central
  • iron ion binding Source: InterPro
  • organic acid binding Source: GO_Central
  • oxygen binding Source: GO_Central
  • oxygen carrier activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit zeta
Alternative name(s):
Alpha-like embryonic globin chain x
Hemoglobin zeta chain
Zeta-globin
Gene namesi
Name:Hbz
Synonyms:Hba-x, Hbz1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96019 Hba-x

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000528522 – 142Hemoglobin subunit zetaAdd BLAST141

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei29PhosphothreonineBy similarity1
Modified residuei53PhosphoserineBy similarity1
Modified residuei73PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP06467
PeptideAtlasiP06467
PRIDEiP06467

PTM databases

iPTMnetiP06467
PhosphoSitePlusiP06467

Expressioni

Gene expression databases

BgeeiENSMUSG00000055609 Expressed in 97 organ(s), highest expression level in trachea
ExpressionAtlasiP06467 baseline and differential
GenevisibleiP06467 MM

Interactioni

Subunit structurei

Heterotetramer of two zeta chains and beta-type chains.By similarity

Protein-protein interaction databases

BioGridi200216, 1 interactor
ComplexPortaliCPX-2938 Early embryonic hemoglobin complex
CPX-2939 Embryonic hemoglobin complex
IntActiP06467, 2 interactors
MINTiP06467
STRINGi10090.ENSMUSP00000020531

Structurei

3D structure databases

ProteinModelPortaliP06467
SMRiP06467
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00760000119197
HOGENOMiHOG000036867
HOVERGENiHBG009709
InParanoidiP06467
KOiK13826
OMAiEVHAAWD
PhylomeDBiP06467
TreeFamiTF332328

Family and domain databases

CDDicd08927 Hb-alpha_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002338 Haemoglobin_a-typ
IPR002340 Haemoglobin_zeta
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00612 ALPHAHAEM
PR00816 ZETAHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P06467-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLMKNERAI IMSMWEKMAA QAEPIGTETL ERLFCSYPQT KTYFPHFDLH
60 70 80 90 100
HGSQQLRAHG FKIMTAVGDA VKSIDNLSSA LTKLSELHAY ILRVDPVNFK
110 120 130 140
LLSHCLLVTM AARFPADFTP EVHEAWDKFM SILSSILTEK YR
Length:142
Mass (Da):16,235
Last modified:January 23, 2007 - v2
Checksum:i9E9D246806744851
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A7M7S6A7M7S6_MOUSE
Hemoglobin X, alpha-like embryonic ...
Hba-x
156Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44F → L in AAA37794 (PubMed:6084630).Curated1
Sequence conflicti108V → L in AAA37702 (PubMed:2444404).Curated1
Sequence conflicti118F → N in AAA37702 (PubMed:2444404).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62302 Genomic DNA Translation: CAA44187.1
M26898 mRNA Translation: AAA37702.1
AK077590 mRNA Translation: BAC36881.1
BC051988 mRNA Translation: AAH51988.1
M13125 mRNA Translation: AAA37794.1
CCDSiCCDS24522.1
PIRiA23283
RefSeqiNP_034535.1, NM_010405.4
UniGeneiMm.141758

Genome annotation databases

EnsembliENSMUST00000020531; ENSMUSP00000020531; ENSMUSG00000055609
GeneIDi15126
KEGGimmu:15126
UCSCiuc007ijj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X62302 Genomic DNA Translation: CAA44187.1
M26898 mRNA Translation: AAA37702.1
AK077590 mRNA Translation: BAC36881.1
BC051988 mRNA Translation: AAH51988.1
M13125 mRNA Translation: AAA37794.1
CCDSiCCDS24522.1
PIRiA23283
RefSeqiNP_034535.1, NM_010405.4
UniGeneiMm.141758

3D structure databases

ProteinModelPortaliP06467
SMRiP06467
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200216, 1 interactor
ComplexPortaliCPX-2938 Early embryonic hemoglobin complex
CPX-2939 Embryonic hemoglobin complex
IntActiP06467, 2 interactors
MINTiP06467
STRINGi10090.ENSMUSP00000020531

PTM databases

iPTMnetiP06467
PhosphoSitePlusiP06467

Proteomic databases

PaxDbiP06467
PeptideAtlasiP06467
PRIDEiP06467

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020531; ENSMUSP00000020531; ENSMUSG00000055609
GeneIDi15126
KEGGimmu:15126
UCSCiuc007ijj.2 mouse

Organism-specific databases

CTDi15126
MGIiMGI:96019 Hba-x

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00760000119197
HOGENOMiHOG000036867
HOVERGENiHBG009709
InParanoidiP06467
KOiK13826
OMAiEVHAAWD
PhylomeDBiP06467
TreeFamiTF332328

Miscellaneous databases

ChiTaRSiHba-x mouse
PROiPR:P06467
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055609 Expressed in 97 organ(s), highest expression level in trachea
ExpressionAtlasiP06467 baseline and differential
GenevisibleiP06467 MM

Family and domain databases

CDDicd08927 Hb-alpha_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002338 Haemoglobin_a-typ
IPR002340 Haemoglobin_zeta
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00612 ALPHAHAEM
PR00816 ZETAHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHBAZ_MOUSE
AccessioniPrimary (citable) accession number: P06467
Secondary accession number(s): Q61654
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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