UniProtKB - P06467 (HBAZ_MOUSE)
Protein
Hemoglobin subunit zeta
Gene
Hbz
Organism
Mus musculus (Mouse)
Status
Functioni
The zeta chain is an alpha-type chain of mammalian embryonic hemoglobin.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 59 | Iron (heme distal ligand) | 1 | |
Metal bindingi | 88 | Iron (heme proximal ligand) | 1 |
GO - Molecular functioni
- heme binding Source: GO_Central
- iron ion binding Source: InterPro
- organic acid binding Source: GO_Central
- oxygen binding Source: GO_Central
- oxygen carrier activity Source: GO_Central
GO - Biological processi
- cellular oxidant detoxification Source: GOC
- erythrocyte maturation Source: MGI
- hydrogen peroxide catabolic process Source: GO_Central
- negative regulation of transcription by RNA polymerase II Source: MGI
Keywordsi
Biological process | Oxygen transport, Transport |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Hemoglobin subunit zetaAlternative name(s): Alpha-like embryonic globin chain x Hemoglobin zeta chain Zeta-globin |
Gene namesi | Name:Hbz Synonyms:Hba-x, Hbz1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96019, Hba-x |
Subcellular locationi
Cytosol
- hemoglobin complex Source: GO_Central
Other locations
- haptoglobin-hemoglobin complex Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000052852 | 2 – 142 | Hemoglobin subunit zetaAdd BLAST | 141 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 29 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 53 | PhosphoserineBy similarity | 1 | |
Modified residuei | 73 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-3819 |
jPOSTi | P06467 |
PaxDbi | P06467 |
PeptideAtlasi | P06467 |
PRIDEi | P06467 |
PTM databases
iPTMneti | P06467 |
PhosphoSitePlusi | P06467 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000055609, Expressed in trachea and 113 other tissues |
ExpressionAtlasi | P06467, baseline and differential |
Genevisiblei | P06467, MM |
Interactioni
Subunit structurei
Heterotetramer of two zeta chains and beta-type chains.
By similarityProtein-protein interaction databases
BioGRIDi | 200216, 4 interactors |
ComplexPortali | CPX-2938, Early embryonic hemoglobin complex CPX-2939, Embryonic hemoglobin complex |
IntActi | P06467, 2 interactors |
MINTi | P06467 |
STRINGi | 10090.ENSMUSP00000020531 |
Miscellaneous databases
RNActi | P06467, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the globin family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG3378, Eukaryota |
GeneTreei | ENSGT00940000158623 |
HOGENOMi | CLU_003827_10_2_1 |
InParanoidi | P06467 |
OMAi | IWAKVAT |
OrthoDBi | 1398217at2759 |
PhylomeDBi | P06467 |
TreeFami | TF332328 |
Family and domain databases
CDDi | cd08927, Hb-alpha_like, 1 hit |
Gene3Di | 1.10.490.10, 1 hit |
InterProi | View protein in InterPro IPR000971, Globin IPR009050, Globin-like_sf IPR012292, Globin/Proto IPR002338, Haemoglobin_a-typ IPR002340, Haemoglobin_zeta |
Pfami | View protein in Pfam PF00042, Globin, 1 hit |
PRINTSi | PR00612, ALPHAHAEM PR00816, ZETAHAEM |
SUPFAMi | SSF46458, SSF46458, 1 hit |
PROSITEi | View protein in PROSITE PS01033, GLOBIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P06467-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLMKNERAI IMSMWEKMAA QAEPIGTETL ERLFCSYPQT KTYFPHFDLH
60 70 80 90 100
HGSQQLRAHG FKIMTAVGDA VKSIDNLSSA LTKLSELHAY ILRVDPVNFK
110 120 130 140
LLSHCLLVTM AARFPADFTP EVHEAWDKFM SILSSILTEK YR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA7M7S6 | A7M7S6_MOUSE | Hemoglobin X, alpha-like embryonic ... | Hba-x | 156 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 44 | F → L in AAA37794 (PubMed:6084630).Curated | 1 | |
Sequence conflicti | 108 | V → L in AAA37702 (PubMed:2444404).Curated | 1 | |
Sequence conflicti | 118 | F → N in AAA37702 (PubMed:2444404).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62302 Genomic DNA Translation: CAA44187.1 M26898 mRNA Translation: AAA37702.1 AK077590 mRNA Translation: BAC36881.1 BC051988 mRNA Translation: AAH51988.1 M13125 mRNA Translation: AAA37794.1 |
CCDSi | CCDS24522.1 |
PIRi | A23283 |
RefSeqi | NP_034535.1, NM_010405.4 |
Genome annotation databases
Ensembli | ENSMUST00000020531; ENSMUSP00000020531; ENSMUSG00000055609 |
GeneIDi | 15126 |
KEGGi | mmu:15126 |
UCSCi | uc007ijj.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X62302 Genomic DNA Translation: CAA44187.1 M26898 mRNA Translation: AAA37702.1 AK077590 mRNA Translation: BAC36881.1 BC051988 mRNA Translation: AAH51988.1 M13125 mRNA Translation: AAA37794.1 |
CCDSi | CCDS24522.1 |
PIRi | A23283 |
RefSeqi | NP_034535.1, NM_010405.4 |
3D structure databases
SMRi | P06467 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200216, 4 interactors |
ComplexPortali | CPX-2938, Early embryonic hemoglobin complex CPX-2939, Embryonic hemoglobin complex |
IntActi | P06467, 2 interactors |
MINTi | P06467 |
STRINGi | 10090.ENSMUSP00000020531 |
PTM databases
iPTMneti | P06467 |
PhosphoSitePlusi | P06467 |
Proteomic databases
CPTACi | non-CPTAC-3819 |
jPOSTi | P06467 |
PaxDbi | P06467 |
PeptideAtlasi | P06467 |
PRIDEi | P06467 |
Protocols and materials databases
Antibodypediai | 8877, 260 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000020531; ENSMUSP00000020531; ENSMUSG00000055609 |
GeneIDi | 15126 |
KEGGi | mmu:15126 |
UCSCi | uc007ijj.2, mouse |
Organism-specific databases
CTDi | 15126 |
MGIi | MGI:96019, Hba-x |
Phylogenomic databases
eggNOGi | KOG3378, Eukaryota |
GeneTreei | ENSGT00940000158623 |
HOGENOMi | CLU_003827_10_2_1 |
InParanoidi | P06467 |
OMAi | IWAKVAT |
OrthoDBi | 1398217at2759 |
PhylomeDBi | P06467 |
TreeFami | TF332328 |
Miscellaneous databases
BioGRID-ORCSi | 15126, 0 hits in 17 CRISPR screens |
ChiTaRSi | Hba-x, mouse |
PROi | PR:P06467 |
RNActi | P06467, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000055609, Expressed in trachea and 113 other tissues |
ExpressionAtlasi | P06467, baseline and differential |
Genevisiblei | P06467, MM |
Family and domain databases
CDDi | cd08927, Hb-alpha_like, 1 hit |
Gene3Di | 1.10.490.10, 1 hit |
InterProi | View protein in InterPro IPR000971, Globin IPR009050, Globin-like_sf IPR012292, Globin/Proto IPR002338, Haemoglobin_a-typ IPR002340, Haemoglobin_zeta |
Pfami | View protein in Pfam PF00042, Globin, 1 hit |
PRINTSi | PR00612, ALPHAHAEM PR00816, ZETAHAEM |
SUPFAMi | SSF46458, SSF46458, 1 hit |
PROSITEi | View protein in PROSITE PS01033, GLOBIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HBAZ_MOUSE | |
Accessioni | P06467Primary (citable) accession number: P06467 Secondary accession number(s): Q61654 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 172 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families