UniProtKB - P06465 (VE7_HPV1)
Protein
Protein E7
Gene
E7
Organism
Human papillomavirus type 1 (Human papillomavirus type 1a)
Status
Functioni
Plays a role in viral genome replication by driving entry of quiescent cells into the cell cycle. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. E7 protein has both transforming and trans-activating activities. Induces the disassembly of the E2F1 transcription factor from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Interferes with host histone deacetylation mediated by HDAC1 and HDAC2, leading to transcription activation. Plays also a role in the inhibition of both antiviral and antiproliferative functions of host interferon alpha. Interaction with host TMEM173/STING impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).UniRule annotation
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 52 – 88 | UniRule annotationAdd BLAST | 37 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
- DNA-binding transcription factor activity Source: UniProtKB-UniRule
- metal ion binding Source: UniProtKB-UniRule
- protein domain specific binding Source: UniProtKB-UniRule
GO - Biological processi
- modulation by virus of host G1/S transition checkpoint Source: UniProtKB-UniRule
- suppression by virus of host type I interferon-mediated signaling pathway Source: UniProtKB-UniRule
- transcription, DNA-templated Source: UniProtKB-UniRule
Keywordsi
Names & Taxonomyi
Protein namesi | Recommended name: Protein E7UniRule annotation |
Gene namesi | Name:E7UniRule annotation |
Organismi | Human papillomavirus type 1 (Human papillomavirus type 1a) |
Taxonomic identifieri | 10583 [NCBI] |
Taxonomic lineagei | Viruses › Monodnaviria › Shotokuvirae › Cossaviricota › Papovaviricetes › Zurhausenvirales › Papillomaviridae › Firstpapillomavirinae › Mupapillomavirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Host cytoplasm UniRule annotation
- Host nucleus UniRule annotation Note: Predominantly found in the host nucleus.UniRule annotation
Keywords - Cellular componenti
Host cytoplasm, Host nucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000133399 | 1 – 93 | Protein E7Add BLAST | 93 |
Post-translational modificationi
Highly phosphorylated.UniRule annotation
Interactioni
Subunit structurei
Homodimer. Homooligomer.
Interacts with host RB1; this interaction induces dissociation of RB1-E2F1 complex thereby disrupting RB1 activity.
Interacts with host EP300; this interaction represses EP300 transcriptional activity.
Interacts with protein E2; this interaction inhibits E7 oncogenic activity.
Interacts with host TMEM173/STING; this interaction impairs the ability of TMEM173/STING to sense cytosolic DNA and promote the production of type I interferon (IFN-alpha and IFN-beta).
UniRule annotationBinary interactionsi
P06465
With | #Exp. | IntAct |
---|---|---|
RB1 [P06400] from Homo sapiens. | 3 | EBI-963841,EBI-491274 |
GO - Molecular functioni
- protein domain specific binding Source: UniProtKB-UniRule
Protein-protein interaction databases
IntActi | P06465, 40 interactors |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P06465 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P06465 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 41 | DisorderedUniRule annotationAdd BLAST | 41 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 24 – 28 | LXCXE motif; interaction with host RB1 and TMEM173/STINGUniRule annotation | 5 | |
Motifi | 70 – 78 | Nuclear export signalUniRule annotation | 9 |
Sequence similaritiesi
Belongs to the papillomaviridae E7 protein family.UniRule annotation
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 52 – 88 | UniRule annotationAdd BLAST | 37 |
Keywords - Domaini
Zinc-fingerFamily and domain databases
HAMAPi | MF_04004, PPV_E7, 1 hit |
InterProi | View protein in InterPro IPR000148, Papilloma_E7 |
Pfami | View protein in Pfam PF00527, E7, 1 hit |
PIRSFi | PIRSF003407, Papvi_E7, 1 hit |
i Sequence
Sequence statusi: Complete.
P06465-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVGEMPALKD LVLQLEPSVL DLDLYCYEEV PPDDIEEELV SPQQPYAVVA
60 70 80 90
SCAYCEKLVR LTVLADHSAI RQLEELLLRS LNIVCPLCTL QRQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V01116 Genomic DNA Translation: CAA24316.1 |
PIRi | C17475, W7WL |
RefSeqi | NP_040307.1, NC_001356.1 |
Genome annotation databases
GeneIDi | 1489171 |
KEGGi | vg:1489171 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V01116 Genomic DNA Translation: CAA24316.1 |
PIRi | C17475, W7WL |
RefSeqi | NP_040307.1, NC_001356.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2B9D | X-ray | 1.60 | A/B | 44-93 | [»] | |
SMRi | P06465 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P06465, 40 interactors |
Genome annotation databases
GeneIDi | 1489171 |
KEGGi | vg:1489171 |
Miscellaneous databases
EvolutionaryTracei | P06465 |
Family and domain databases
HAMAPi | MF_04004, PPV_E7, 1 hit |
InterProi | View protein in InterPro IPR000148, Papilloma_E7 |
Pfami | View protein in Pfam PF00527, E7, 1 hit |
PIRSFi | PIRSF003407, Papvi_E7, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VE7_HPV1 | |
Accessioni | P06465Primary (citable) accession number: P06465 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | January 1, 1988 | |
Last modified: | April 7, 2021 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families