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Protein

Prothymosin alpha

Gene

PTMA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.

GO - Molecular functioni

  • activating transcription factor binding Source: CAFA
  • histone binding Source: Ensembl

GO - Biological processi

  • histone exchange Source: Ensembl
  • transcription, DNA-templated Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Prothymosin alpha
Cleaved into the following 2 chains:
Gene namesi
Name:PTMA
Synonyms:TMSA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000187514.14
HGNCiHGNC:9623 PTMA
MIMi188390 gene
neXtProtiNX_P06454

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5757
OpenTargetsiENSG00000187514
PharmGKBiPA33966

Polymorphism and mutation databases

BioMutaiPTMA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004232551 – 111Prothymosin alphaAdd BLAST111
Initiator methionineiRemoved; alternateCombined sources2 Publications
ChainiPRO_00002992502 – 111Prothymosin alpha, N-terminally processedAdd BLAST110
PeptideiPRO_00000298652 – 29Thymosin alpha-1Add BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylserine; in Prothymosin alpha, N-terminally processedCombined sources2 Publications1
Modified residuei2PhosphoserineCombined sources1 Publication1
Modified residuei8PhosphothreonineBy similarity1
Modified residuei9PhosphoserineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei13PhosphothreonineBy similarity1
Modified residuei14PhosphothreonineBy similarity1
Modified residuei15N6-acetyllysine; alternateCombined sources1
Modified residuei15N6-succinyllysine; alternateBy similarity1
Modified residuei102PhosphothreonineCombined sources1
Modified residuei103N6-acetyllysine; alternateBy similarity1
Cross-linki103Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei107PhosphothreonineCombined sources1

Post-translational modificationi

Covalently linked to a small RNA of about 20 nucleotides.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP06454
MaxQBiP06454
PaxDbiP06454
PeptideAtlasiP06454
PRIDEiP06454
ProteomicsDBi51903
51904 [P06454-2]
TopDownProteomicsiP06454-1 [P06454-1]
P06454-2 [P06454-2]

PTM databases

iPTMnetiP06454
PhosphoSitePlusiP06454

Miscellaneous databases

PMAP-CutDBiP06454

Expressioni

Gene expression databases

BgeeiENSG00000187514 Expressed in 91 organ(s), highest expression level in left coronary artery
CleanExiHS_PTMA
ExpressionAtlasiP06454 baseline and differential
GenevisibleiP06454 HS

Organism-specific databases

HPAiHPA047183

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111724, 70 interactors
DIPiDIP-40743N
IntActiP06454, 17 interactors
MINTiP06454
STRINGi9606.ENSP00000344547

Structurei

Secondary structure

1111
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP06454
SMRiP06454
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 101Asp/Glu-rich (acidic)Add BLAST60

Sequence similaritiesi

Belongs to the pro/parathymosin family.Curated

Phylogenomic databases

eggNOGiENOG410J563 Eukaryota
ENOG410ZA5I LUCA
GeneTreeiENSGT00730000111051
HOGENOMiHOG000089972
InParanoidiP06454
KOiK13784
TreeFamiTF350357

Family and domain databases

InterProiView protein in InterPro
IPR004931 Pro/parathymosin
PANTHERiPTHR22745 PTHR22745, 1 hit
PfamiView protein in Pfam
PF03247 Prothymosin, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P06454-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDAAVDTSS EITTKDLKEK KEVVEEAENG RDAPANGNAE NEENGEQEAD
60 70 80 90 100
NEVDEEEEEG GEEEEEEEEG DGEEEDGDED EEAESATGKR AAEDDEDDDV
110
DTKKQKTDED D
Length:111
Mass (Da):12,203
Last modified:January 23, 2007 - v2
Checksum:i910BBF9D8D14B8E7
GO
Isoform 2 (identifier: P06454-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-40: Missing.

Show »
Length:110
Mass (Da):12,074
Checksum:i3A76436E79930993
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8ZZQ6B8ZZQ6_HUMAN
Prothymosin alpha
PTMA
107Annotation score:
B8ZZA1B8ZZA1_HUMAN
Prothymosin alpha
PTMA
131Annotation score:
B8ZZW7B8ZZW7_HUMAN
Prothymosin alpha
PTMA
136Annotation score:
H7C2N1H7C2N1_HUMAN
Prothymosin alpha
PTMA
148Annotation score:
H7C031H7C031_HUMAN
Prothymosin alpha
PTMA
74Annotation score:
F8WCE8F8WCE8_HUMAN
Prothymosin alpha
PTMA
43Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01150840Missing in isoform 2. 4 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14630 mRNA Translation: AAA61182.1
M14483 mRNA Translation: AAA61183.1
M67480, J04797 Genomic DNA Translation: AAA63240.1
M67480, J04797 Genomic DNA Translation: AAA63239.1
M26708 mRNA Translation: AAA60213.1
AF348514 mRNA Translation: AAK30146.1
BC051265 mRNA Translation: AAH51265.1
BC066905 mRNA Translation: AAH66905.1
BC070480 mRNA Translation: AAH70480.1
BC071647 mRNA Translation: AAH71647.1
BC071879 mRNA Translation: AAH71879.1
S56449 Genomic DNA Translation: AAD13882.1
CCDSiCCDS42833.1 [P06454-1]
CCDS46541.1 [P06454-2]
PIRiA42004 TNHUA
C33356
RefSeqiNP_001092755.1, NM_001099285.1 [P06454-1]
NP_002814.3, NM_002823.4 [P06454-2]
UniGeneiHs.459927

Genome annotation databases

EnsembliENST00000341369; ENSP00000344547; ENSG00000187514 [P06454-1]
ENST00000409115; ENSP00000386819; ENSG00000187514 [P06454-2]
GeneIDi5757
KEGGihsa:5757
UCSCiuc002vsc.5 human [P06454-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14630 mRNA Translation: AAA61182.1
M14483 mRNA Translation: AAA61183.1
M67480, J04797 Genomic DNA Translation: AAA63240.1
M67480, J04797 Genomic DNA Translation: AAA63239.1
M26708 mRNA Translation: AAA60213.1
AF348514 mRNA Translation: AAK30146.1
BC051265 mRNA Translation: AAH51265.1
BC066905 mRNA Translation: AAH66905.1
BC070480 mRNA Translation: AAH70480.1
BC071647 mRNA Translation: AAH71647.1
BC071879 mRNA Translation: AAH71879.1
S56449 Genomic DNA Translation: AAD13882.1
CCDSiCCDS42833.1 [P06454-1]
CCDS46541.1 [P06454-2]
PIRiA42004 TNHUA
C33356
RefSeqiNP_001092755.1, NM_001099285.1 [P06454-1]
NP_002814.3, NM_002823.4 [P06454-2]
UniGeneiHs.459927

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L9INMR-A2-29[»]
2MNQNMR-A2-29[»]
ProteinModelPortaliP06454
SMRiP06454
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111724, 70 interactors
DIPiDIP-40743N
IntActiP06454, 17 interactors
MINTiP06454
STRINGi9606.ENSP00000344547

PTM databases

iPTMnetiP06454
PhosphoSitePlusiP06454

Polymorphism and mutation databases

BioMutaiPTMA

Proteomic databases

EPDiP06454
MaxQBiP06454
PaxDbiP06454
PeptideAtlasiP06454
PRIDEiP06454
ProteomicsDBi51903
51904 [P06454-2]
TopDownProteomicsiP06454-1 [P06454-1]
P06454-2 [P06454-2]

Protocols and materials databases

DNASUi5757
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341369; ENSP00000344547; ENSG00000187514 [P06454-1]
ENST00000409115; ENSP00000386819; ENSG00000187514 [P06454-2]
GeneIDi5757
KEGGihsa:5757
UCSCiuc002vsc.5 human [P06454-1]

Organism-specific databases

CTDi5757
DisGeNETi5757
EuPathDBiHostDB:ENSG00000187514.14
GeneCardsiPTMA
HGNCiHGNC:9623 PTMA
HPAiHPA047183
MIMi188390 gene
neXtProtiNX_P06454
OpenTargetsiENSG00000187514
PharmGKBiPA33966
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J563 Eukaryota
ENOG410ZA5I LUCA
GeneTreeiENSGT00730000111051
HOGENOMiHOG000089972
InParanoidiP06454
KOiK13784
TreeFamiTF350357

Miscellaneous databases

ChiTaRSiPTMA human
GeneWikiiThymosin_%CE%B11
GenomeRNAii5757
PMAP-CutDBiP06454
PROiPR:P06454
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187514 Expressed in 91 organ(s), highest expression level in left coronary artery
CleanExiHS_PTMA
ExpressionAtlasiP06454 baseline and differential
GenevisibleiP06454 HS

Family and domain databases

InterProiView protein in InterPro
IPR004931 Pro/parathymosin
PANTHERiPTHR22745 PTHR22745, 1 hit
PfamiView protein in Pfam
PF03247 Prothymosin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPTMA_HUMAN
AccessioniPrimary (citable) accession number: P06454
Secondary accession number(s): Q15249, Q15592
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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