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Protein

Prothymosin alpha

Gene

PTMA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections.

GO - Molecular functioni

  • activating transcription factor binding Source: CAFA
  • histone binding Source: Ensembl

GO - Biological processi

  • histone exchange Source: Ensembl
  • transcription, DNA-templated Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Prothymosin alpha
Cleaved into the following 2 chains:
Gene namesi
Name:PTMA
Synonyms:TMSA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000187514.14
HGNCiHGNC:9623 PTMA
MIMi188390 gene
neXtProtiNX_P06454

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi5757
OpenTargetsiENSG00000187514
PharmGKBiPA33966

Polymorphism and mutation databases

BioMutaiPTMA

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004232551 – 111Prothymosin alphaAdd BLAST111
Initiator methionineiRemoved; alternateCombined sources2 Publications
ChainiPRO_00002992502 – 111Prothymosin alpha, N-terminally processedAdd BLAST110
PeptideiPRO_00000298652 – 29Thymosin alpha-1Add BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylserine; in Prothymosin alpha, N-terminally processedCombined sources2 Publications1
Modified residuei2PhosphoserineCombined sources1 Publication1
Modified residuei8PhosphothreonineBy similarity1
Modified residuei9PhosphoserineCombined sources1
Modified residuei10PhosphoserineCombined sources1
Modified residuei13PhosphothreonineBy similarity1
Modified residuei14PhosphothreonineBy similarity1
Modified residuei15N6-acetyllysine; alternateCombined sources1
Modified residuei15N6-succinyllysine; alternateBy similarity1
Modified residuei102PhosphothreonineCombined sources1
Modified residuei103N6-acetyllysine; alternateBy similarity1
Cross-linki103Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei107PhosphothreonineCombined sources1

Post-translational modificationi

Covalently linked to a small RNA of about 20 nucleotides.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP06454
MaxQBiP06454
PaxDbiP06454
PeptideAtlasiP06454
PRIDEiP06454
ProteomicsDBi51903
51904 [P06454-2]
TopDownProteomicsiP06454-1 [P06454-1]
P06454-2 [P06454-2]

PTM databases

iPTMnetiP06454
PhosphoSitePlusiP06454

Miscellaneous databases

PMAP-CutDBiP06454

Expressioni

Gene expression databases

BgeeiENSG00000187514
CleanExiHS_PTMA
ExpressionAtlasiP06454 baseline and differential
GenevisibleiP06454 HS

Organism-specific databases

HPAiHPA047183

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • activating transcription factor binding Source: CAFA
  • histone binding Source: Ensembl

Protein-protein interaction databases

BioGridi111724, 69 interactors
DIPiDIP-40743N
IntActiP06454, 16 interactors
MINTiP06454
STRINGi9606.ENSP00000344547

Structurei

Secondary structure

1111
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 6Combined sources4
Helixi9 – 28Combined sources20

3D structure databases

ProteinModelPortaliP06454
SMRiP06454
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 101Asp/Glu-rich (acidic)Add BLAST60

Sequence similaritiesi

Belongs to the pro/parathymosin family.Curated

Phylogenomic databases

eggNOGiENOG410J563 Eukaryota
ENOG410ZA5I LUCA
GeneTreeiENSGT00730000111051
HOGENOMiHOG000089972
InParanoidiP06454
KOiK13784
TreeFamiTF350357

Family and domain databases

InterProiView protein in InterPro
IPR004931 Pro/parathymosin
PANTHERiPTHR22745 PTHR22745, 1 hit
PfamiView protein in Pfam
PF03247 Prothymosin, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P06454-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDAAVDTSS EITTKDLKEK KEVVEEAENG RDAPANGNAE NEENGEQEAD
60 70 80 90 100
NEVDEEEEEG GEEEEEEEEG DGEEEDGDED EEAESATGKR AAEDDEDDDV
110
DTKKQKTDED D
Length:111
Mass (Da):12,203
Last modified:January 23, 2007 - v2
Checksum:i910BBF9D8D14B8E7
GO
Isoform 2 (identifier: P06454-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     40-40: Missing.

Show »
Length:110
Mass (Da):12,074
Checksum:i3A76436E79930993
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01150840Missing in isoform 2. 4 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14630 mRNA Translation: AAA61182.1
M14483 mRNA Translation: AAA61183.1
M67480, J04797 Genomic DNA Translation: AAA63240.1
M67480, J04797 Genomic DNA Translation: AAA63239.1
M26708 mRNA Translation: AAA60213.1
AF348514 mRNA Translation: AAK30146.1
BC051265 mRNA Translation: AAH51265.1
BC066905 mRNA Translation: AAH66905.1
BC070480 mRNA Translation: AAH70480.1
BC071647 mRNA Translation: AAH71647.1
BC071879 mRNA Translation: AAH71879.1
S56449 Genomic DNA Translation: AAD13882.1
CCDSiCCDS42833.1 [P06454-1]
CCDS46541.1 [P06454-2]
PIRiA42004 TNHUA
C33356
RefSeqiNP_001092755.1, NM_001099285.1 [P06454-1]
NP_002814.3, NM_002823.4 [P06454-2]
UniGeneiHs.459927

Genome annotation databases

EnsembliENST00000341369; ENSP00000344547; ENSG00000187514 [P06454-1]
ENST00000409115; ENSP00000386819; ENSG00000187514 [P06454-2]
GeneIDi5757
KEGGihsa:5757
UCSCiuc002vsc.5 human [P06454-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPTMA_HUMAN
AccessioniPrimary (citable) accession number: P06454
Secondary accession number(s): Q15249, Q15592
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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