PGR

Functionⁱ

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.

Curated3 Publications

Isoform A:

Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2.

Curated3 Publications

Isoform B:

Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.

1 Publication

Isoform 4:

Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	567 – 639	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	73
Zinc fingerⁱ	567 – 587	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	603 – 627	NR C4-typePROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding, Receptor
Biological process	Transcription, Transcription regulation
Ligand	Lipid-binding, Metal-binding, Steroid-binding, Zinc

Enzyme and pathway databases

PathwayCommonsⁱ	P06401
Reactomeⁱ	R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-4090294, SUMOylation of intracellular receptors R-HSA-9018519, Estrogen-dependent gene expression
SignaLinkⁱ	P06401
SIGNORⁱ	P06401

Protein family/group databases

TCDBⁱ	9.B.208.1.5, the vitamin d3 receptor (vdr) family

TCDBⁱ

9.B.208.1.5, the vitamin d3 receptor (vdr) family

Chemistry databases

SwissLipidsⁱ	SLP:000001574

SwissLipidsⁱ

SLP:000001574

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Progesterone receptor Short name: PR Alternative name(s): Nuclear receptor subfamily 3 group C member 3
Gene namesⁱ	Name:PGR Synonyms:NR3C3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:8910, PGR
MIMⁱ	607311, gene
neXtProtⁱ	NX_P06401
VEuPathDBⁱ	HostDB:ENSG00000082175

Keywords - Cellular componentⁱ

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	7	K → R: Some loss of sumoylation; when associated with R-531. Complete loss of sumoylation; when associated with R-388 and R-531. 1 Publication	1
Mutagenesisⁱ	55	L → A: Reduces transcriptional activation; when associated with A-58 and A-59. 1 Publication	1
Mutagenesisⁱ	58	L → A: Reduces transcriptional activation; when associated with A-55 and A-59. 1 Publication	1
Mutagenesisⁱ	59	L → A: Reduces transcriptional activation; when associated with A-55 and A-58. 1 Publication	1
Mutagenesisⁱ	115	L → A: Reduces transcriptional activation; when associated with A-118 and A-119. 1 Publication	1
Mutagenesisⁱ	118	L → A: Reduces transcriptional activation; when associated with A-115 and A-119. 1 Publication	1
Mutagenesisⁱ	119	L → A: Reduces transcriptional activation; when associated with A-115 and A-118. 1 Publication	1
Mutagenesisⁱ	140	W → A, F or R: Reduces transcriptional activation. 1 Publication	1
Mutagenesisⁱ	294	S → A: No effect on interaction with CUEDC2. Impaired progesterone-induced transcriptional activity. No CUEDC2- nor progestin-mediated protein degradation. No change in sumoylation; when associated with A-344 and A-345. 3 Publications	1
Mutagenesisⁱ	294	S → D: Decreases protein stability and increases progesterone-induced transcriptional activity. 3 Publications	1
Mutagenesisⁱ	344	S → A: No interaction with SP1. No change in progestin-induced protein degradation; when associated with A-345. No change in sumoylation; when associated with A-294 and A-345. 2 Publications	1
Mutagenesisⁱ	345	S → A: No change in progestin-induced protein degradation; when associated with A-344. No change in sumoylation; when associated with A-294 and A-344. 2 Publications	1
Mutagenesisⁱ	388	K → R: Great loss of sumoylation; when associated with R-7. Completely abolishes sumoylation; when associated with R-7 and R-531. Loss of CUEDC2-mediated protein degradation. Increased ligand-dependent transcriptional activity. 3 Publications	1
Mutagenesisⁱ	400	S → A: Abolishes CDK2-induced activity in the absence, but not in the presence, of progestin. Delayed nuclear translocation in presence of progestin. 2 Publications	1
Mutagenesisⁱ	531	K → R: Some loss of sumoylation; when associated with R-7. Completely abolishes sumoylation; when associated with R-7 and R-388. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5241
MalaCards human disease database More...MalaCardsⁱ	PGR
Open Targets More...OpenTargetsⁱ	ENSG00000082175
PharmGKBⁱ	PA266

Miscellaneous databases

Pharosⁱ	P06401, Tclin

Pharosⁱ

P06401, Tclin

Chemistry databases

ChEMBLⁱ	CHEMBL208
Drug and drug target database More...DrugBankⁱ	DB01431, Allylestrenol DB06680, Asoprisnil DB01406, Danazol DB12941, Darolutamide DB13857, Demegestone DB00304, Desogestrel DB09123, Dienogest DB01395, Drospirenone DB00378, Dydrogesterone DB11219, Enzacamene DB00823, Ethynodiol diacetate DB00294, Etonogestrel DB13867, Fluticasone DB08906, Fluticasone furoate DB00588, Fluticasone propionate DB06730, Gestodene DB11619, Gestrinone DB11064, Homosalate DB06789, Hydroxyprogesterone caproate DB00367, Levonorgestrel DB00431, Lindane DB09124, Medrogestone DB00603, Medroxyprogesterone acetate DB00351, Megestrol acetate DB02998, Metribolone DB00834, Mifepristone DB00648, Mitotane DB00764, Mometasone DB14512, Mometasone furoate DB06713, Norelgestromin DB00717, Norethisterone DB00957, Norgestimate DB09389, Norgestrel DB01428, Oxybenzone DB02746, Phthalic Acid DB00396, Progesterone DB14583, Segesterone acetate DB00421, Spironolactone DB04787, Tanaproget DB05253, Telapristone acetate DB08867, Ulipristal
DrugCentral More...DrugCentralⁱ	P06401
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	627

Genetic variation databases

BioMutaⁱ	PGR
DMDMⁱ	90110048

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053693	1 – 933	Progesterone receptorAdd BLAST		933

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	7	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Modified residueⁱ	20	Phosphoserine1 Publication	1
Modified residueⁱ	81	Phosphoserine2 Publications	1
Modified residueⁱ	102	Phosphoserine2 Publications	1
Modified residueⁱ	130	Phosphoserine1 Publication	1
Modified residueⁱ	162	PhosphoserineCombined sources5 Publications	1
Modified residueⁱ	190	Phosphoserine4 Publications	1
Modified residueⁱ	213	Phosphoserine1 Publication	1
Modified residueⁱ	294	Phosphoserine; by MAPK17 Publications	1
Modified residueⁱ	345	Phosphoserine; by MAPK3 Publications	1
Cross-linkⁱ	388	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Cross-linkⁱ	388	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Modified residueⁱ	400	Phosphoserine; by CDK23 Publications	1
Cross-linkⁱ	531	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Modified residueⁱ	676	Phosphoserine1 Publication	1

Post-translational modificationⁱ

Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 occurs preferentially on isoform B, is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-102 and Ser-345 also requires induction by hormone. Basal phosphorylation on Ser-81, Ser-162, Ser-190 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMA and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at Ser-190, is impaired during the G₂/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1.13 Publications

Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-294.9 Publications

Ubiquitination is hormone-dependent and represses sumoylation on the same site. Promoted by MAPK-mediated phosphorylation on Ser-294.7 Publications

Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOSTⁱ	P06401
MassIVEⁱ	P06401
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P06401
PaxDbⁱ	P06401
PeptideAtlas More...PeptideAtlasⁱ	P06401
PRIDEⁱ	P06401
ProteomicsDBⁱ	51901 [P06401-1] 51902 [P06401-2] 5919 74334

PTM databases

GlyGenⁱ	P06401, 1 site, 1 O-linked glycan (1 site)
iPTMnetⁱ	P06401
PhosphoSitePlusⁱ	P06401
SwissPalmⁱ	P06401

Expressionⁱ

Tissue specificityⁱ

In reproductive tissues the expression of isoform A and isoform B varies as a consequence of developmental and hormonal status. Isoform A and isoform B are expressed in comparable levels in uterine glandular epithelium during the proliferative phase of the menstrual cycle. Expression of isoform B but not of isoform A persists in the glands during mid-secretory phase. In the stroma, isoform A is the predominant form throughout the cycle. Heterogeneous isoform expression between the glands of the endometrium basalis and functionalis is implying region-specific responses to hormonal stimuli.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000082175, Expressed in endometrium and 173 other tissues
ExpressionAtlasⁱ	P06401, baseline and differential
Genevisibleⁱ	P06401, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000082175, Group enriched (cervix, endometrium, fallopian tube, smooth muscle)

HPAⁱ

ENSG00000082175, Group enriched (cervix, endometrium, fallopian tube, smooth muscle)

Interactionⁱ

Subunit structureⁱ

Interacts with SMARD1 and UNC45A.

Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and represses transcriptional activity.

Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export.

Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2 MAPK.

Interacts with PRMT2. Isoform A interacts with NCOR2. Isoform B (but not isoform A) interacts with NCOA2 and NCOA1. Isoform B (but not isoform A) interacts with KLF9.

Interacts with GTF2B (PubMed:1517211).

By similarity8 Publications

Binary interactionsⁱ

Hide details

P06401

With	#Exp.	IntAct
CUEDC2 [Q9H467]	9	EBI-78539,EBI-1248228
ESR1 [P03372]	20	EBI-78539,EBI-78473
itself	2	EBI-78539,EBI-78539
STAT3 [P40763]	3	EBI-78539,EBI-518675

Isoform B [P06401-1]

With	#Exp.	IntAct
ESR1 [P03372]	4	EBI-12590474,EBI-78473

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	111260, 70 interactors
Database of interacting proteins More...DIPⁱ	DIP-5967N
ELMⁱ	P06401
IntActⁱ	P06401, 89 interactors
Molecular INTeraction database More...MINTⁱ	P06401
STRINGⁱ	9606.ENSP00000325120

Chemistry databases

BindingDBⁱ

P06401

Miscellaneous databases

RNActⁱ	P06401, protein

RNActⁱ

P06401, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	568 – 570	Combined sources	3
Beta strandⁱ	576 – 578	Combined sources	3
Beta strandⁱ	581 – 583	Combined sources	3
Helixⁱ	585 – 596	Combined sources	12
Beta strandⁱ	604 – 607	Combined sources	4
Turnⁱ	613 – 618	Combined sources	6
Helixⁱ	620 – 629	Combined sources	10
Helixⁱ	686 – 694	Combined sources	9
Helixⁱ	711 – 735	Combined sources	25
Helixⁱ	739 – 741	Combined sources	3
Helixⁱ	744 – 771	Combined sources	28
Beta strandⁱ	774 – 779	Combined sources	6
Beta strandⁱ	782 – 784	Combined sources	3
Helixⁱ	786 – 788	Combined sources	3
Helixⁱ	792 – 811	Combined sources	20
Helixⁱ	815 – 826	Combined sources	12
Beta strandⁱ	828 – 830	Combined sources	3
Helixⁱ	838 – 857	Combined sources	20
Helixⁱ	863 – 896	Combined sources	34
Helixⁱ	898 – 901	Combined sources	4
Helixⁱ	907 – 921	Combined sources	15
Beta strandⁱ	925 – 927	Combined sources	3

Show more details

3D structure databases

SMRⁱ	P06401
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P06401

EvolutionaryTraceⁱ

P06401

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	679 – 913	NR LBDPROSITE-ProRule annotationAdd BLAST		235

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 566	Modulating, Pro-RichAdd BLAST	566
Regionⁱ	1 – 164	AF3; mediates transcriptional activation (in isoform B)1 PublicationAdd BLAST	164
Regionⁱ	1 – 157	DisorderedSequence analysisAdd BLAST	157
Regionⁱ	165 – 305	Mediates transcriptional transrepression (in isoform A)1 PublicationAdd BLAST	141
Regionⁱ	195 – 241	DisorderedSequence analysisAdd BLAST	47
Regionⁱ	331 – 351	DisorderedSequence analysisAdd BLAST	21
Regionⁱ	415 – 452	DisorderedSequence analysisAdd BLAST	38
Regionⁱ	456 – 546	AF1; mediates transcriptional activation1 PublicationAdd BLAST	91
Regionⁱ	687 – 933	AF2; mediates transcriptional activation1 PublicationAdd BLAST	247

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	55 – 59	LXXL motif 11 Publication	5
Motifⁱ	115 – 119	LXXL motif 21 Publication	5
Motifⁱ	183 – 187	Nuclear localization signalSequence analysis	5

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	68 – 84	Polar residuesSequence analysisAdd BLAST	17
Compositional biasⁱ	120 – 135	Polar residuesSequence analysisAdd BLAST	16
Compositional biasⁱ	415 – 431	Pro residuesSequence analysisAdd BLAST	17

Domainⁱ

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR3 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	567 – 587	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	603 – 627	NR C4-typePROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3575, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000159713
HOGENOMⁱ	CLU_014081_0_0_1
InParanoidⁱ	P06401
OMAⁱ	YKAEGAQ
Database of Orthologous Groups More...OrthoDBⁱ	615449at2759
PhylomeDBⁱ	P06401
TreeFamⁱ	TF106510

Family and domain databases

Database of protein disorder More...DisProtⁱ	DP01542
Gene3Dⁱ	1.10.565.10, 1 hit 3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR000128, Progest_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104, Hormone_recep, 1 hit PF02161, Prog_receptor, 1 hit PF00105, zf-C4, 1 hit
PRINTSⁱ	PR00544, PROGESTRONER PR00398, STRDHORMONER PR00047, STROIDFINGER
SMARTⁱ	View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508, SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative promoter usage and alternative splicing. Align Add to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform B (identifier: P06401-1) [UniParc]FASTA Add to basket

Also known as: PRB, PR-B

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTELKAKGPR APHVAGGPPS PEVGSPLLCR PAAGPFPGSQ TSDTLPEVSA 
        60         70         80         90        100
IPISLDGLLF PRPCQGQDPS DEKTQDQQSL SDVEGAYSRA EATRGAGGSS 
       110        120        130        140        150
SSPPEKDSGL LDSVLDTLLA PSGPGQSQPS PPACEVTSSW CLFGPELPED 
       160        170        180        190        200
PPAAPATQRV LSPLMSRSGC KVGDSSGTAA AHKVLPRGLS PARQLLLPAS 
       210        220        230        240        250
ESPHWSGAPV KPSPQAAAVE VEEEDGSESE ESAGPLLKGK PRALGGAAAG 
       260        270        280        290        300
GGAAAVPPGA AAGGVALVPK EDSRFSAPRV ALVEQDAPMA PGRSPLATTV 
       310        320        330        340        350
MDFIHVPILP LNHALLAART RQLLEDESYD GGAGAASAFA PPRSSPCASS 
       360        370        380        390        400
TPVAVGDFPD CAYPPDAEPK DDAYPLYSDF QPPALKIKEE EEGAEASARS 
       410        420        430        440        450
PRSYLVAGAN PAAFPDFPLG PPPPLPPRAT PSRPGEAAVT AAPASASVSS 
       460        470        480        490        500
ASSSGSTLEC ILYKAEGAPP QQGPFAPPPC KAPGASGCLL PRDGLPSTSA 
       510        520        530        540        550
SAAAAGAAPA LYPALGLNGL PQLGYQAAVL KEGLPQVYPP YLNYLRPDSE 
       560        570        580        590        600
ASQSPQYSFE SLPQKICLIC GDEASGCHYG VLTCGSCKVF FKRAMEGQHN 
       610        620        630        640        650
YLCAGRNDCI VDKIRRKNCP ACRLRKCCQA GMVLGGRKFK KFNKVRVVRA 
       660        670        680        690        700
LDAVALPQPV GVPNESQALS QRFTFSPGQD IQLIPPLINL LMSIEPDVIY 
       710        720        730        740        750
AGHDNTKPDT SSSLLTSLNQ LGERQLLSVV KWSKSLPGFR NLHIDDQITL 
       760        770        780        790        800
IQYSWMSLMV FGLGWRSYKH VSGQMLYFAP DLILNEQRMK ESSFYSLCLT 
       810        820        830        840        850
MWQIPQEFVK LQVSQEEFLC MKVLLLLNTI PLEGLRSQTQ FEEMRSSYIR 
       860        870        880        890        900
ELIKAIGLRQ KGVVSSSQRF YQLTKLLDNL HDLVKQLHLY CLNTFIQSRA 
       910        920        930 
LSVEFPEMMS EVIAAQLPKI LAGMVKPLLF HKK

Note: Produced by alternative promoter usage.

Length:933

Mass (Da):98,981

Last modified:March 21, 2006 - v4

Checksum:ⁱ80452E54FF3A0454

GO

Isoform A (identifier: P06401-2) [UniParc]FASTA Add to basket

Also known as: PRA, PR-A

The sequence of this isoform differs from the canonical sequence as follows:
1-164: Missing.

« Hide

        10         20         30         40         50
MSRSGCKVGD SSGTAAAHKV LPRGLSPARQ LLLPASESPH WSGAPVKPSP 
        60         70         80         90        100
QAAAVEVEEE DGSESEESAG PLLKGKPRAL GGAAAGGGAA AVPPGAAAGG 
       110        120        130        140        150
VALVPKEDSR FSAPRVALVE QDAPMAPGRS PLATTVMDFI HVPILPLNHA 
       160        170        180        190        200
LLAARTRQLL EDESYDGGAG AASAFAPPRS SPCASSTPVA VGDFPDCAYP 
       210        220        230        240        250
PDAEPKDDAY PLYSDFQPPA LKIKEEEEGA EASARSPRSY LVAGANPAAF 
       260        270        280        290        300
PDFPLGPPPP LPPRATPSRP GEAAVTAAPA SASVSSASSS GSTLECILYK 
       310        320        330        340        350
AEGAPPQQGP FAPPPCKAPG ASGCLLPRDG LPSTSASAAA AGAAPALYPA 
       360        370        380        390        400
LGLNGLPQLG YQAAVLKEGL PQVYPPYLNY LRPDSEASQS PQYSFESLPQ 
       410        420        430        440        450
KICLICGDEA SGCHYGVLTC GSCKVFFKRA MEGQHNYLCA GRNDCIVDKI 
       460        470        480        490        500
RRKNCPACRL RKCCQAGMVL GGRKFKKFNK VRVVRALDAV ALPQPVGVPN 
       510        520        530        540        550
ESQALSQRFT FSPGQDIQLI PPLINLLMSI EPDVIYAGHD NTKPDTSSSL 
       560        570        580        590        600
LTSLNQLGER QLLSVVKWSK SLPGFRNLHI DDQITLIQYS WMSLMVFGLG 
       610        620        630        640        650
WRSYKHVSGQ MLYFAPDLIL NEQRMKESSF YSLCLTMWQI PQEFVKLQVS 
       660        670        680        690        700
QEEFLCMKVL LLLNTIPLEG LRSQTQFEEM RSSYIRELIK AIGLRQKGVV 
       710        720        730        740        750
SSSQRFYQLT KLLDNLHDLV KQLHLYCLNT FIQSRALSVE FPEMMSEVIA 
       760 
AQLPKILAGM VKPLLFHKK

Note: Produced by alternative promoter usage.Curated

Show »

Length:769

Mass (Da):82,295

Checksum:ⁱFE676F25282983F3

GO

Isoform 3 (identifier: P06401-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-594: Missing.

« Hide

        10         20         30         40         50
MEGQHNYLCA GRNDCIVDKI RRKNCPACRL RKCCQAGMVL GGRKFKKFNK 
        60         70         80         90        100
VRVVRALDAV ALPQPVGVPN ESQALSQRFT FSPGQDIQLI PPLINLLMSI 
       110        120        130        140        150
EPDVIYAGHD NTKPDTSSSL LTSLNQLGER QLLSVVKWSK SLPGFRNLHI 
       160        170        180        190        200
DDQITLIQYS WMSLMVFGLG WRSYKHVSGQ MLYFAPDLIL NEQRMKESSF 
       210        220        230        240        250
YSLCLTMWQI PQEFVKLQVS QEEFLCMKVL LLLNTIPLEG LRSQTQFEEM 
       260        270        280        290        300
RSSYIRELIK AIGLRQKGVV SSSQRFYQLT KLLDNLHDLV KQLHLYCLNT 
       310        320        330 
FIQSRALSVE FPEMMSEVIA AQLPKILAGM VKPLLFHKK

Note: Produced by alternative splicing of isoform B.Curated

Show »

Length:339

Mass (Da):38,798

Checksum:ⁱ4496D6B5A4EC95FD

GO

Isoform 4 (identifier: P06401-4) [UniParc]FASTA Add to basket

Also known as: PR-M

The sequence of this isoform differs from the canonical sequence as follows:
1-16: MTELKAKGPRAPHVAG → MEFIYIYMNFFFFFSV
17-635: Missing.

« Hide

        10         20         30         40         50
MEFIYIYMNF FFFFSVGRKF KKFNKVRVVR ALDAVALPQP VGVPNESQAL 
        60         70         80         90        100
SQRFTFSPGQ DIQLIPPLIN LLMSIEPDVI YAGHDNTKPD TSSSLLTSLN 
       110        120        130        140        150
QLGERQLLSV VKWSKSLPGF RNLHIDDQIT LIQYSWMSLM VFGLGWRSYK 
       160        170        180        190        200
HVSGQMLYFA PDLILNEQRM KESSFYSLCL TMWQIPQEFV KLQVSQEEFL 
       210        220        230        240        250
CMKVLLLLNT IPLEGLRSQT QFEEMRSSYI RELIKAIGLR QKGVVSSSQR 
       260        270        280        290        300
FYQLTKLLDN LHDLVKQLHL YCLNTFIQSR ALSVEFPEMM SEVIAAQLPK 
       310 
ILAGMVKPLL FHKK

Note: Produced by alternative promoter usage.Curated

Show »

Length:314

Mass (Da):36,318

Checksum:ⁱA85692E905BFB9B3

GO

Isoform 5 (identifier: P06401-5) [UniParc]FASTA Add to basket

Also known as: delta4

The sequence of this isoform differs from the canonical sequence as follows:
636-737: Missing.

« Hide

        10         20         30         40         50
MTELKAKGPR APHVAGGPPS PEVGSPLLCR PAAGPFPGSQ TSDTLPEVSA 
        60         70         80         90        100
IPISLDGLLF PRPCQGQDPS DEKTQDQQSL SDVEGAYSRA EATRGAGGSS 
       110        120        130        140        150
SSPPEKDSGL LDSVLDTLLA PSGPGQSQPS PPACEVTSSW CLFGPELPED 
       160        170        180        190        200
PPAAPATQRV LSPLMSRSGC KVGDSSGTAA AHKVLPRGLS PARQLLLPAS 
       210        220        230        240        250
ESPHWSGAPV KPSPQAAAVE VEEEDGSESE ESAGPLLKGK PRALGGAAAG 
       260        270        280        290        300
GGAAAVPPGA AAGGVALVPK EDSRFSAPRV ALVEQDAPMA PGRSPLATTV 
       310        320        330        340        350
MDFIHVPILP LNHALLAART RQLLEDESYD GGAGAASAFA PPRSSPCASS 
       360        370        380        390        400
TPVAVGDFPD CAYPPDAEPK DDAYPLYSDF QPPALKIKEE EEGAEASARS 
       410        420        430        440        450
PRSYLVAGAN PAAFPDFPLG PPPPLPPRAT PSRPGEAAVT AAPASASVSS 
       460        470        480        490        500
ASSSGSTLEC ILYKAEGAPP QQGPFAPPPC KAPGASGCLL PRDGLPSTSA 
       510        520        530        540        550
SAAAAGAAPA LYPALGLNGL PQLGYQAAVL KEGLPQVYPP YLNYLRPDSE 
       560        570        580        590        600
ASQSPQYSFE SLPQKICLIC GDEASGCHYG VLTCGSCKVF FKRAMEGQHN 
       610        620        630        640        650
YLCAGRNDCI VDKIRRKNCP ACRLRKCCQA GMVLGGFRNL HIDDQITLIQ 
       660        670        680        690        700
YSWMSLMVFG LGWRSYKHVS GQMLYFAPDL ILNEQRMKES SFYSLCLTMW 
       710        720        730        740        750
QIPQEFVKLQ VSQEEFLCMK VLLLLNTIPL EGLRSQTQFE EMRSSYIREL 
       760        770        780        790        800
IKAIGLRQKG VVSSSQRFYQ LTKLLDNLHD LVKQLHLYCL NTFIQSRALS 
       810        820        830 
VEFPEMMSEV IAAQLPKILA GMVKPLLFHK K

Note: Produced by alternative splicing of isoform B.Curated

Show »

Length:831

Mass (Da):87,747

Checksum:ⁱEC4882171DD1C48B

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q8NG44	Q8NG44_HUMAN	Progesterone receptor Progesterone receptor, PR (Nuclear receptor subfamily 3 group C member 3)	PGR PR, hCG_39657	764	Annotation score:
Q8NG45	Q8NG45_HUMAN	Progesterone receptor Progesterone receptor, PR (Nuclear receptor subfamily 3 group C member 3)	PGR PR, hCG_39657	695	Annotation score:
Q8NG42	Q8NG42_HUMAN	Progesterone receptor Progesterone receptor, PR (Nuclear receptor subfamily 3 group C member 3)	PGR PR, hCG_39657	803	Annotation score:
A0A087WXR4	A0A087WXR4_HUMAN	Progesterone receptor Progesterone receptor, PR (Nuclear receptor subfamily 3 group C member 3)	PGR	690	Annotation score:
A0A0J9YVP1	A0A0J9YVP1_HUMAN	Progesterone receptor Progesterone receptor	PGR	170	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	226	G → S in CAA36018 (PubMed:2328727).Curated		1
Sequence conflictⁱ	256	V → S in CAA36018 (PubMed:2328727).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_019221	50	A → T1 PublicationCorresponds to variant dbSNP:rs11571143Ensembl.	1
Natural variantⁱVAR_019222	120	A → V1 PublicationCorresponds to variant dbSNP:rs11571144EnsemblClinVar.	1
Natural variantⁱVAR_019223	186	P → L1 PublicationCorresponds to variant dbSNP:rs11571145Ensembl.	1
Natural variantⁱVAR_019224	301	M → R1 PublicationCorresponds to variant dbSNP:rs11571146Ensembl.	1
Natural variantⁱVAR_016117	344	S → T2 PublicationsCorresponds to variant dbSNP:rs3740753Ensembl.	1
Natural variantⁱVAR_025555	347	C → S. Corresponds to variant dbSNP:rs11571147EnsemblClinVar.	1
Natural variantⁱVAR_019225	444	A → S1 PublicationCorresponds to variant dbSNP:rs11571150Ensembl.	1
Natural variantⁱVAR_019226	529	V → L1 PublicationCorresponds to variant dbSNP:rs11571151Ensembl.	1
Natural variantⁱVAR_019227	536	Q → P1 PublicationCorresponds to variant dbSNP:rs11571152EnsemblClinVar.	1
Natural variantⁱVAR_014627	625	R → I. Corresponds to variant dbSNP:rs2020874Ensembl.	1
Natural variantⁱVAR_019228	651	L → V1 PublicationCorresponds to variant dbSNP:rs11571222EnsemblClinVar.	1
Natural variantⁱVAR_016118	660	V → L3 PublicationsCorresponds to variant dbSNP:rs1042838Ensembl.	1
Natural variantⁱVAR_014628	865	S → L1 PublicationCorresponds to variant dbSNP:rs2020880Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_046942	1 – 594	Missing in isoform 3. 1 PublicationAdd BLAST	594
Alternative sequenceⁱVSP_003706	1 – 164	Missing in isoform A. CuratedAdd BLAST	164
Alternative sequenceⁱVSP_047454	1 – 16	MTELK…PHVAG → MEFIYIYMNFFFFFSV in isoform 4. 1 PublicationAdd BLAST	16
Alternative sequenceⁱVSP_047455	17 – 635	Missing in isoform 4. 1 PublicationAdd BLAST	619
Alternative sequenceⁱVSP_053543	636 – 737	Missing in isoform 5. 1 PublicationAdd BLAST	102

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X51730 mRNA Translation: CAA36018.1 M15716 mRNA Translation: AAA60081.1 AF016381 mRNA Translation: AAD01587.1 AB084248 mRNA Translation: BAB91074.1 DQ234979 Genomic DNA Translation: ABB72139.1 AY212933 mRNA Translation: AAO61671.1 AK304853 mRNA Translation: BAG65592.1 AY525610 Genomic DNA Translation: AAS00096.1 AP001533 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW66999.1 CH471065 Genomic DNA Translation: EAW67000.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS59229.1 [P06401-3] CCDS8310.1 [P06401-1]
PIRⁱ	S09971, QRHUP
NCBI Reference Sequences More...RefSeqⁱ	NP_000917.3, NM_000926.4 [P06401-1] NP_001189403.1, NM_001202474.3 [P06401-2] NP_001258090.1, NM_001271161.2 NP_001258091.1, NM_001271162.1 [P06401-3]

Genome annotation databases

Ensemblⁱ	ENST00000263463; ENSP00000263463; ENSG00000082175 [P06401-5] ENST00000325455; ENSP00000325120; ENSG00000082175 ENST00000534013; ENSP00000436561; ENSG00000082175 [P06401-3]
GeneIDⁱ	5241
KEGGⁱ	hsa:5241
MANE-Selectⁱ	ENST00000325455.10; ENSP00000325120.5; NM_000926.4; NP_000917.3
UCSC genome browser More...UCSCⁱ	uc001pgh.3, human [P06401-1]

Keywords - Coding sequence diversityⁱ

Alternative promoter usage, Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P06401	Isoform 3 of Progesterone receptor		HUMAN		339	UniRef100_P06401
Isoform A of Progesterone receptor		HUMAN		769
Progesterone receptor (Fragment)		HUMAN		101
Progesterone receptor B isoform (Fragment)		HUMAN		80

Protein	Similar proteins		Species	Score	Length	Source
P06401	Progesterone receptor		COLGU		934	UniRef90_P06401
Progesterone receptor		PANPA		933
Progesterone receptor		PAPAN		933
Progesterone receptor		CHLAE		933
Progesterone receptor		TRAOB		933
+70
P06401-4	Progesterone receptor		SHEEP		347	UniRef90_P06401-4
(mimic poison frog) hypothetical protein		mimic poison frog		318
+4

Protein	Similar proteins		Species	Score	Length	Source
P06401	Progesterone receptor		COLGU		934	UniRef50_P06401
Progesterone receptor		CHLAE		933
Progesterone receptor		PANTR		933
Progesterone receptor		GORGO		933
Progesterone receptor		PAPAN		933
+424
P06401-4	Progesterone receptor		SHEEP		347	UniRef50_P06401-4
(mimic poison frog) hypothetical protein		mimic poison frog		318
Androgen receptor		ATHCN		351
Androgen receptor		CRIGR		295
Androgen receptor (Fragment)		BOVIN		295
+24

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Wikipedia

Progesterone receptor entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X51730 mRNA Translation: CAA36018.1 M15716 mRNA Translation: AAA60081.1 AF016381 mRNA Translation: AAD01587.1 AB084248 mRNA Translation: BAB91074.1 DQ234979 Genomic DNA Translation: ABB72139.1 AY212933 mRNA Translation: AAO61671.1 AK304853 mRNA Translation: BAG65592.1 AY525610 Genomic DNA Translation: AAS00096.1 AP001533 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW66999.1 CH471065 Genomic DNA Translation: EAW67000.1
CCDSⁱ	CCDS59229.1 [P06401-3] CCDS8310.1 [P06401-1]
PIRⁱ	S09971, QRHUP
RefSeqⁱ	NP_000917.3, NM_000926.4 [P06401-1] NP_001189403.1, NM_001202474.3 [P06401-2] NP_001258090.1, NM_001271161.2 NP_001258091.1, NM_001271162.1 [P06401-3]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1A28	X-ray	1.80	A/B	678-933	[»]
	1E3K	X-ray	2.80	A/B	676-933	[»]
	1SQN	X-ray	1.45	A/B	673-933	[»]
	1SR7	X-ray	1.46	A/B	676-933	[»]
	1ZUC	X-ray	2.00	A/B	676-933	[»]
	2C7A	X-ray	2.50	A/B	563-640	[»]
	2OVH	X-ray	2.00	A	678-933	[»]
	2OVM	X-ray	2.60	A	678-933	[»]
	2W8Y	X-ray	1.80	A/B	678-933	[»]
	3D90	X-ray	2.26	A/B	676-933	[»]
	3G8O	X-ray	1.90	A/B	673-933	[»]
	3HQ5	X-ray	2.10	A/B	678-933	[»]
	3KBA	X-ray	2.00	A/B	681-933	[»]
	3ZR7	X-ray	1.65	A/B	678-933	[»]
	3ZRA	X-ray	1.90	A/B	678-933	[»]
	3ZRB	X-ray	1.80	A/B	678-933	[»]
	4A2J	X-ray	2.00	A/B	678-933	[»]
	4APU	X-ray	1.90	A/B	678-933	[»]
	4OAR	X-ray	2.41	A	678-933	[»]
	5CC0	X-ray	2.40	A/B	561-641	[»]
SMRⁱ	P06401
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	111260, 70 interactors
DIPⁱ	DIP-5967N
ELMⁱ	P06401
IntActⁱ	P06401, 89 interactors
MINTⁱ	P06401
STRINGⁱ	9606.ENSP00000325120

Chemistry databases

BindingDBⁱ	P06401
ChEMBLⁱ	CHEMBL208
DrugBankⁱ	DB01431, Allylestrenol DB06680, Asoprisnil DB01406, Danazol DB12941, Darolutamide DB13857, Demegestone DB00304, Desogestrel DB09123, Dienogest DB01395, Drospirenone DB00378, Dydrogesterone DB11219, Enzacamene DB00823, Ethynodiol diacetate DB00294, Etonogestrel DB13867, Fluticasone DB08906, Fluticasone furoate DB00588, Fluticasone propionate DB06730, Gestodene DB11619, Gestrinone DB11064, Homosalate DB06789, Hydroxyprogesterone caproate DB00367, Levonorgestrel DB00431, Lindane DB09124, Medrogestone DB00603, Medroxyprogesterone acetate DB00351, Megestrol acetate DB02998, Metribolone DB00834, Mifepristone DB00648, Mitotane DB00764, Mometasone DB14512, Mometasone furoate DB06713, Norelgestromin DB00717, Norethisterone DB00957, Norgestimate DB09389, Norgestrel DB01428, Oxybenzone DB02746, Phthalic Acid DB00396, Progesterone DB14583, Segesterone acetate DB00421, Spironolactone DB04787, Tanaproget DB05253, Telapristone acetate DB08867, Ulipristal
DrugCentralⁱ	P06401
GuidetoPHARMACOLOGYⁱ	627
SwissLipidsⁱ	SLP:000001574

Protein family/group databases

TCDBⁱ	9.B.208.1.5, the vitamin d3 receptor (vdr) family

TCDBⁱ

9.B.208.1.5, the vitamin d3 receptor (vdr) family

PTM databases

GlyGenⁱ	P06401, 1 site, 1 O-linked glycan (1 site)
iPTMnetⁱ	P06401
PhosphoSitePlusⁱ	P06401
SwissPalmⁱ	P06401

Genetic variation databases

BioMutaⁱ	PGR
DMDMⁱ	90110048

Proteomic databases

jPOSTⁱ	P06401
MassIVEⁱ	P06401
MaxQBⁱ	P06401
PaxDbⁱ	P06401
PeptideAtlasⁱ	P06401
PRIDEⁱ	P06401
ProteomicsDBⁱ	51901 [P06401-1] 51902 [P06401-2] 5919 74334

Protocols and materials databases

Antibodypediaⁱ	1685, 2968 antibodies from 54 providers
The CPTC Antibody Portal More...CPTCⁱ	P06401, 2 antibodies
The DNASU plasmid repository More...DNASUⁱ	5241

Genome annotation databases

Ensemblⁱ	ENST00000263463; ENSP00000263463; ENSG00000082175 [P06401-5] ENST00000325455; ENSP00000325120; ENSG00000082175 ENST00000534013; ENSP00000436561; ENSG00000082175 [P06401-3]
GeneIDⁱ	5241
KEGGⁱ	hsa:5241
MANE-Selectⁱ	ENST00000325455.10; ENSP00000325120.5; NM_000926.4; NP_000917.3
UCSCⁱ	uc001pgh.3, human [P06401-1]

Organism-specific databases

CTDⁱ	5241
DisGeNETⁱ	5241
GeneCardsⁱ	PGR
HGNCⁱ	HGNC:8910, PGR
HPAⁱ	ENSG00000082175, Group enriched (cervix, endometrium, fallopian tube, smooth muscle)
MalaCardsⁱ	PGR
MIMⁱ	607311, gene
neXtProtⁱ	NX_P06401
OpenTargetsⁱ	ENSG00000082175
PharmGKBⁱ	PA266
VEuPathDBⁱ	HostDB:ENSG00000082175
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3575, Eukaryota
GeneTreeⁱ	ENSGT00940000159713
HOGENOMⁱ	CLU_014081_0_0_1
InParanoidⁱ	P06401
OMAⁱ	YKAEGAQ
OrthoDBⁱ	615449at2759
PhylomeDBⁱ	P06401
TreeFamⁱ	TF106510

Enzyme and pathway databases

PathwayCommonsⁱ	P06401
Reactomeⁱ	R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-4090294, SUMOylation of intracellular receptors R-HSA-9018519, Estrogen-dependent gene expression
SignaLinkⁱ	P06401
SIGNORⁱ	P06401

Miscellaneous databases

BioGRID-ORCSⁱ	5241, 3 hits in 1065 CRISPR screens
ChiTaRSⁱ	PGR, human
EvolutionaryTraceⁱ	P06401
GeneWikiⁱ	Progesterone_receptor
GenomeRNAiⁱ	5241
Pharosⁱ	P06401, Tclin
Protein Ontology More...PROⁱ	PR:P06401
RNActⁱ	P06401, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000082175, Expressed in endometrium and 173 other tissues
ExpressionAtlasⁱ	P06401, baseline and differential
Genevisibleⁱ	P06401, HS

Family and domain databases

DisProtⁱ	DP01542
Gene3Dⁱ	1.10.565.10, 1 hit 3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR000128, Progest_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104, Hormone_recep, 1 hit PF02161, Prog_receptor, 1 hit PF00105, zf-C4, 1 hit
PRINTSⁱ	PR00544, PROGESTRONER PR00398, STRDHORMONER PR00047, STROIDFINGER
SMARTⁱ	View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508, SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PRGR_HUMAN
Accessionⁱ	P06401Primary (citable) accession number: P06401 Secondary accession number(s): A7LQ08 , A7X8B0, B4E3T0, Q8TDS3, Q9UPF7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
	Last sequence update:	March 21, 2006
	Last modified:	February 23, 2022
	This is version 252 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P06401 (PRGR_HUMAN)

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Progesterone receptor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

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Enzyme and pathway databases

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoplasm and Cytosol

Nucleus

Cytoplasm and Cytosol

Mitochondrion

Cytosol

Mitochondrion

Nucleus

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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Organism-specific databases

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Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

P06401

Isoform B [P06401-1]

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Motif

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

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Functionⁱ

GO - Molecular functionⁱ

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Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

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Keywords - Technical termⁱ