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UniProtKB - P06401 (PRGR_HUMAN)

Protein

Progesterone receptor

Gene

PGR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.Curated3 Publications
Isoform A: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2.Curated3 Publications
Isoform B: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.1 Publication
Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi567 – 639Nuclear receptorPROSITE-ProRule annotationAdd BLAST73
Zinc fingeri567 – 587NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri603 – 627NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandLipid-binding, Metal-binding, Steroid-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-1251985 Nuclear signaling by ERBB4
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-4090294 SUMOylation of intracellular receptors
R-HSA-9018519 Estrogen-dependent gene expression
SignaLinkiP06401
SIGNORiP06401

Chemistry databases

SwissLipidsiSLP:000001574

Names & Taxonomyi

Protein namesi
Recommended name:
Progesterone receptor
Short name:
PR
Alternative name(s):
Nuclear receptor subfamily 3 group C member 3
Gene namesi
Name:PGR
Synonyms:NR3C3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000082175.14
HGNCiHGNC:8910 PGR
MIMi607311 gene
neXtProtiNX_P06401

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi7K → R: Some loss of sumoylation; when associated with R-531. Complete loss of sumoylation; when associated with R-388 and R-531. 1 Publication1
Mutagenesisi55L → A: Reduces transcriptional activation; when associated with A-58 and A-59. 1 Publication1
Mutagenesisi58L → A: Reduces transcriptional activation; when associated with A-55 and A-59. 1 Publication1
Mutagenesisi59L → A: Reduces transcriptional activation; when associated with A-55 and A-58. 1 Publication1
Mutagenesisi115L → A: Reduces transcriptional activation; when associated with A-118 and A-119. 1 Publication1
Mutagenesisi118L → A: Reduces transcriptional activation; when associated with A-115 and A-119. 1 Publication1
Mutagenesisi119L → A: Reduces transcriptional activation; when associated with A-115 and A-118. 1 Publication1
Mutagenesisi140W → A, F or R: Reduces transcriptional activation. 1 Publication1
Mutagenesisi294S → A: No effect on interaction with CUEDC2. Impaired progesterone-induced transcriptional activity. No CUEDC2- nor progestin-mediated protein degradation. No change in sumoylation; when associated with A-344 and A-345. 3 Publications1
Mutagenesisi294S → D: Decreases protein stability and increases progesterone-induced transcriptional activity. 3 Publications1
Mutagenesisi344S → A: No interaction with SP1. No change in progestin-induced protein degradation; when associated with A-345. No change in sumoylation; when associated with A-294 and A-345. 2 Publications1
Mutagenesisi345S → A: No change in progestin-induced protein degradation; when associated with A-344. No change in sumoylation; when associated with A-294 and A-344. 2 Publications1
Mutagenesisi388K → R: Great loss of sumoylation; when associated with R-7. Completely abolishes sumoylation; when associated with R-7 and R-531. Loss of CUEDC2-mediated protein degradation. Increased ligand-dependent transcriptional activity. 3 Publications1
Mutagenesisi400S → A: Abolishes CDK2-induced activity in the absence, but not in the presence, of progestin. Delayed nuclear translocation in presence of progestin. 2 Publications1
Mutagenesisi531K → R: Some loss of sumoylation; when associated with R-7. Completely abolishes sumoylation; when associated with R-7 and R-388. 1 Publication1

Organism-specific databases

DisGeNETi5241
MalaCardsiPGR
OpenTargetsiENSG00000082175
PharmGKBiPA266

Chemistry databases

ChEMBLiCHEMBL208
DrugBankiDB01431 Allylestrenol
DB01406 Danazol
DB00304 Desogestrel
DB01395 Drospirenone
DB00378 Dydrogesterone
DB00823 Ethynodiol diacetate
DB00294 Etonogestrel
DB00588 Fluticasone Propionate
DB06789 Hydroxyprogesterone caproate
DB00367 Levonorgestrel
DB00603 Medroxyprogesterone acetate
DB00351 Megestrol acetate
DB02998 Methyltrienolone
DB00834 Mifepristone
DB06713 Norelgestromin
DB00717 Norethisterone
DB00957 Norgestimate
DB09389 Norgestrel
DB05253 Proellex
DB00396 Progesterone
DB00421 Spironolactone
DB04787 Tanaproget
DB08867 Ulipristal
GuidetoPHARMACOLOGYi627

Polymorphism and mutation databases

BioMutaiPGR
DMDMi90110048

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000536931 – 933Progesterone receptorAdd BLAST933

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki7Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Modified residuei20Phosphoserine1 Publication1
Modified residuei81Phosphoserine2 Publications1
Modified residuei102Phosphoserine2 Publications1
Modified residuei130Phosphoserine1 Publication1
Modified residuei162PhosphoserineCombined sources5 Publications1
Modified residuei190Phosphoserine4 Publications1
Modified residuei213Phosphoserine1 Publication1
Modified residuei294Phosphoserine; by MAPK17 Publications1
Modified residuei345Phosphoserine; by MAPK3 Publications1
Cross-linki388Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Cross-linki388Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Modified residuei400Phosphoserine; by CDK23 Publications1
Cross-linki531Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Modified residuei676Phosphoserine1 Publication1

Post-translational modificationi

Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 occurs preferentially on isoform B, is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-102 and Ser-345 also requires induction by hormone. Basal phosphorylation on Ser-81, Ser-162, Ser-190 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMA and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at Ser-190, is impaired during the G2/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1.13 Publications
Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-294.9 Publications
Ubiquitination is hormone-dependent and represses sumoylation on the same site. Promoted by MAPK-mediated phosphorylation on Ser-294.7 Publications
Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation.1 Publication

Keywords - PTMi

Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP06401
PaxDbiP06401
PeptideAtlasiP06401
PRIDEiP06401
ProteomicsDBi51901
51902 [P06401-2]

PTM databases

iPTMnetiP06401
PhosphoSitePlusiP06401
SwissPalmiP06401

Expressioni

Tissue specificityi

In reproductive tissues the expression of isoform A and isoform B varies as a consequence of developmental and hormonal status. Isoform A and isoform B are expressed in comparable levels in uterine glandular epithelium during the proliferative phase of the menstrual cycle. Expression of isoform B but not of isoform A persists in the glands during mid-secretory phase. In the stroma, isoform A is the predominant form throughout the cycle. Heterogeneous isoform expression between the glands of the endometrium basalis and functionalis is implying region-specific responses to hormonal stimuli.1 Publication

Gene expression databases

BgeeiENSG00000082175 Expressed in 153 organ(s), highest expression level in endometrium
CleanExiHS_PGR
ExpressionAtlasiP06401 baseline and differential
GenevisibleiP06401 HS

Organism-specific databases

HPAiCAB000068
CAB055100
HPA004751
HPA008428
HPA017176

Interactioni

Subunit structurei

Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and represses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2 MAPK. Interacts with PRMT2. Isoform A interacts with NCOR2. Isoform B (but not isoform A) interacts with NCOA2 and NCOA1. Isoform B (but not isoform A) interacts with KLF9. Interacts with GTF2B (PubMed:1517211).By similarity8 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi111260, 68 interactors
DIPiDIP-5967N
ELMiP06401
IntActiP06401, 14 interactors
MINTiP06401
STRINGi9606.ENSP00000325120

Chemistry databases

BindingDBiP06401

Structurei

Secondary structure

1933
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP06401
SMRiP06401
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP06401

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini679 – 913NR LBDPROSITE-ProRule annotationAdd BLAST235

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 566Modulating, Pro-RichAdd BLAST566
Regioni1 – 164AF3; mediates transcriptional activation (in isoform B)1 PublicationAdd BLAST164
Regioni165 – 305Mediates transcriptional transrepression (in isoform A)1 PublicationAdd BLAST141
Regioni456 – 546AF1; mediates transcriptional activation1 PublicationAdd BLAST91
Regioni687 – 933AF2; mediates transcriptional activation1 PublicationAdd BLAST247

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi55 – 59LXXL motif 11 Publication5
Motifi115 – 119LXXL motif 21 Publication5
Motifi183 – 187Nuclear localization signalSequence analysis5

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR3 subfamily.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri567 – 587NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri603 – 627NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00760000118887
HOGENOMiHOG000290653
HOVERGENiHBG007583
InParanoidiP06401
KOiK08556
OMAiCAYPPDA
OrthoDBiEOG091G04YC
PhylomeDBiP06401
TreeFamiTF106510

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR000128 Progest_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF02161 Prog_receptor, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00544 PROGESTRONER
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 2 hits
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.iShow all

Isoform B (identifier: P06401-1) [UniParc]FASTAAdd to basket
Also known as: PRB, PR-B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTELKAKGPR APHVAGGPPS PEVGSPLLCR PAAGPFPGSQ TSDTLPEVSA 
        60         70         80         90        100
IPISLDGLLF PRPCQGQDPS DEKTQDQQSL SDVEGAYSRA EATRGAGGSS 
       110        120        130        140        150
SSPPEKDSGL LDSVLDTLLA PSGPGQSQPS PPACEVTSSW CLFGPELPED 
       160        170        180        190        200
PPAAPATQRV LSPLMSRSGC KVGDSSGTAA AHKVLPRGLS PARQLLLPAS 
       210        220        230        240        250
ESPHWSGAPV KPSPQAAAVE VEEEDGSESE ESAGPLLKGK PRALGGAAAG 
       260        270        280        290        300
GGAAAVPPGA AAGGVALVPK EDSRFSAPRV ALVEQDAPMA PGRSPLATTV 
       310        320        330        340        350
MDFIHVPILP LNHALLAART RQLLEDESYD GGAGAASAFA PPRSSPCASS 
       360        370        380        390        400
TPVAVGDFPD CAYPPDAEPK DDAYPLYSDF QPPALKIKEE EEGAEASARS 
       410        420        430        440        450
PRSYLVAGAN PAAFPDFPLG PPPPLPPRAT PSRPGEAAVT AAPASASVSS 
       460        470        480        490        500
ASSSGSTLEC ILYKAEGAPP QQGPFAPPPC KAPGASGCLL PRDGLPSTSA 
       510        520        530        540        550
SAAAAGAAPA LYPALGLNGL PQLGYQAAVL KEGLPQVYPP YLNYLRPDSE 
       560        570        580        590        600
ASQSPQYSFE SLPQKICLIC GDEASGCHYG VLTCGSCKVF FKRAMEGQHN 
       610        620        630        640        650
YLCAGRNDCI VDKIRRKNCP ACRLRKCCQA GMVLGGRKFK KFNKVRVVRA 
       660        670        680        690        700
LDAVALPQPV GVPNESQALS QRFTFSPGQD IQLIPPLINL LMSIEPDVIY 
       710        720        730        740        750
AGHDNTKPDT SSSLLTSLNQ LGERQLLSVV KWSKSLPGFR NLHIDDQITL 
       760        770        780        790        800
IQYSWMSLMV FGLGWRSYKH VSGQMLYFAP DLILNEQRMK ESSFYSLCLT 
       810        820        830        840        850
MWQIPQEFVK LQVSQEEFLC MKVLLLLNTI PLEGLRSQTQ FEEMRSSYIR 
       860        870        880        890        900
ELIKAIGLRQ KGVVSSSQRF YQLTKLLDNL HDLVKQLHLY CLNTFIQSRA 
       910        920        930 
LSVEFPEMMS EVIAAQLPKI LAGMVKPLLF HKK
Note: Produced by alternative promoter usage.
Length:933
Mass (Da):98,981
Last modified:March 21, 2006 - v4
Checksum:i80452E54FF3A0454
GO
Isoform A (identifier: P06401-2) [UniParc]FASTAAdd to basket
Also known as: PRA, PR-A

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:769
Mass (Da):82,295
Checksum:iFE676F25282983F3
GO
Isoform 3 (identifier: P06401-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-594: Missing.

Note: Produced by alternative splicing of isoform B.
Show »
Length:339
Mass (Da):38,798
Checksum:i4496D6B5A4EC95FD
GO
Isoform 4 (identifier: P06401-4) [UniParc]FASTAAdd to basket
Also known as: PR-M

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MTELKAKGPRAPHVAG → MEFIYIYMNFFFFFSV
     17-635: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:314
Mass (Da):36,318
Checksum:iA85692E905BFB9B3
GO
Isoform 5 (identifier: P06401-5) [UniParc]FASTAAdd to basket
Also known as: delta4

The sequence of this isoform differs from the canonical sequence as follows:
     636-737: Missing.

Note: Produced by alternative splicing of isoform B.
Show »
Length:831
Mass (Da):87,747
Checksum:iEC4882171DD1C48B
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8NG45Q8NG45_HUMAN
Progesterone receptor, isoform CRA_...
PGR PR, hCG_39657
695Annotation score:
Q8NG42Q8NG42_HUMAN
Delta 6/2 progesterone receptor
PGR PR, hCG_39657
803Annotation score:
Q8NG44Q8NG44_HUMAN
Delta 3+6/2 progesterone receptor
PGR PR, hCG_39657
764Annotation score:
A0A087WXR4A0A087WXR4_HUMAN
Progesterone receptor
PGR
690Annotation score:
A0A0J9YVP1A0A0J9YVP1_HUMAN
Progesterone receptor
PGR
170Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti226G → S in CAA36018 (PubMed:2328727).Curated1
Sequence conflicti256V → S in CAA36018 (PubMed:2328727).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01922150A → T1 PublicationCorresponds to variant dbSNP:rs11571143Ensembl.1
Natural variantiVAR_019222120A → V1 PublicationCorresponds to variant dbSNP:rs11571144Ensembl.1
Natural variantiVAR_019223186P → L1 PublicationCorresponds to variant dbSNP:rs11571145Ensembl.1
Natural variantiVAR_019224301M → R1 PublicationCorresponds to variant dbSNP:rs11571146Ensembl.1
Natural variantiVAR_016117344S → T2 PublicationsCorresponds to variant dbSNP:rs3740753Ensembl.1
Natural variantiVAR_025555347C → S. Corresponds to variant dbSNP:rs11571147Ensembl.1
Natural variantiVAR_019225444A → S1 PublicationCorresponds to variant dbSNP:rs11571150Ensembl.1
Natural variantiVAR_019226529V → L1 PublicationCorresponds to variant dbSNP:rs11571151Ensembl.1
Natural variantiVAR_019227536Q → P1 PublicationCorresponds to variant dbSNP:rs11571152Ensembl.1
Natural variantiVAR_014627625R → I. Corresponds to variant dbSNP:rs2020874Ensembl.1
Natural variantiVAR_019228651L → V1 PublicationCorresponds to variant dbSNP:rs11571222Ensembl.1
Natural variantiVAR_016118660V → L3 PublicationsCorresponds to variant dbSNP:rs1042838Ensembl.1
Natural variantiVAR_014628865S → L1 PublicationCorresponds to variant dbSNP:rs2020880Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0469421 – 594Missing in isoform 3. 1 PublicationAdd BLAST594
Alternative sequenceiVSP_0037061 – 164Missing in isoform A. CuratedAdd BLAST164
Alternative sequenceiVSP_0474541 – 16MTELK…PHVAG → MEFIYIYMNFFFFFSV in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_04745517 – 635Missing in isoform 4. 1 PublicationAdd BLAST619
Alternative sequenceiVSP_053543636 – 737Missing in isoform 5. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51730 mRNA Translation: CAA36018.1
M15716 mRNA Translation: AAA60081.1
AF016381 mRNA Translation: AAD01587.1
AB084248 mRNA Translation: BAB91074.1
DQ234979 Genomic DNA Translation: ABB72139.1
AY212933 mRNA Translation: AAO61671.1
AK304853 mRNA Translation: BAG65592.1
AY525610 Genomic DNA Translation: AAS00096.1
AP001533 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW66999.1
CH471065 Genomic DNA Translation: EAW67000.1
CCDSiCCDS59229.1 [P06401-3]
CCDS8310.1 [P06401-1]
PIRiS09971 QRHUP
RefSeqiNP_000917.3, NM_000926.4 [P06401-1]
NP_001189403.1, NM_001202474.3 [P06401-2]
NP_001258090.1, NM_001271161.2
NP_001258091.1, NM_001271162.1 [P06401-3]
UniGeneiHs.32405
Hs.742403

Genome annotation databases

EnsembliENST00000263463; ENSP00000263463; ENSG00000082175 [P06401-5]
ENST00000325455; ENSP00000325120; ENSG00000082175 [P06401-1]
ENST00000534013; ENSP00000436561; ENSG00000082175 [P06401-3]
GeneIDi5241
KEGGihsa:5241
UCSCiuc001pgh.3 human [P06401-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs
Wikipedia

Progesterone receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51730 mRNA Translation: CAA36018.1
M15716 mRNA Translation: AAA60081.1
AF016381 mRNA Translation: AAD01587.1
AB084248 mRNA Translation: BAB91074.1
DQ234979 Genomic DNA Translation: ABB72139.1
AY212933 mRNA Translation: AAO61671.1
AK304853 mRNA Translation: BAG65592.1
AY525610 Genomic DNA Translation: AAS00096.1
AP001533 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW66999.1
CH471065 Genomic DNA Translation: EAW67000.1
CCDSiCCDS59229.1 [P06401-3]
CCDS8310.1 [P06401-1]
PIRiS09971 QRHUP
RefSeqiNP_000917.3, NM_000926.4 [P06401-1]
NP_001189403.1, NM_001202474.3 [P06401-2]
NP_001258090.1, NM_001271161.2
NP_001258091.1, NM_001271162.1 [P06401-3]
UniGeneiHs.32405
Hs.742403

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A28X-ray1.80A/B678-933[»]
1E3KX-ray2.80A/B676-933[»]
1SQNX-ray1.45A/B673-933[»]
1SR7X-ray1.46A/B676-933[»]
1ZUCX-ray2.00A/B676-933[»]
2C7AX-ray2.50A/B563-640[»]
2OVHX-ray2.00A678-933[»]
2OVMX-ray2.60A678-933[»]
2W8YX-ray1.80A/B678-933[»]
3D90X-ray2.26A/B676-933[»]
3G8OX-ray1.90A/B673-933[»]
3HQ5X-ray2.10A/B678-933[»]
3KBAX-ray2.00A/B681-933[»]
3ZR7X-ray1.65A/B678-933[»]
3ZRAX-ray1.90A/B678-933[»]
3ZRBX-ray1.80A/B678-933[»]
4A2JX-ray2.00A/B678-933[»]
4APUX-ray1.90A/B678-933[»]
4OARX-ray2.41A678-933[»]
5CC0X-ray2.40A/B561-641[»]
ProteinModelPortaliP06401
SMRiP06401
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111260, 68 interactors
DIPiDIP-5967N
ELMiP06401
IntActiP06401, 14 interactors
MINTiP06401
STRINGi9606.ENSP00000325120

Chemistry databases

BindingDBiP06401
ChEMBLiCHEMBL208
DrugBankiDB01431 Allylestrenol
DB01406 Danazol
DB00304 Desogestrel
DB01395 Drospirenone
DB00378 Dydrogesterone
DB00823 Ethynodiol diacetate
DB00294 Etonogestrel
DB00588 Fluticasone Propionate
DB06789 Hydroxyprogesterone caproate
DB00367 Levonorgestrel
DB00603 Medroxyprogesterone acetate
DB00351 Megestrol acetate
DB02998 Methyltrienolone
DB00834 Mifepristone
DB06713 Norelgestromin
DB00717 Norethisterone
DB00957 Norgestimate
DB09389 Norgestrel
DB05253 Proellex
DB00396 Progesterone
DB00421 Spironolactone
DB04787 Tanaproget
DB08867 Ulipristal
GuidetoPHARMACOLOGYi627
SwissLipidsiSLP:000001574

PTM databases

iPTMnetiP06401
PhosphoSitePlusiP06401
SwissPalmiP06401

Polymorphism and mutation databases

BioMutaiPGR
DMDMi90110048

Proteomic databases

MaxQBiP06401
PaxDbiP06401
PeptideAtlasiP06401
PRIDEiP06401
ProteomicsDBi51901
51902 [P06401-2]

Protocols and materials databases

DNASUi5241
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263463; ENSP00000263463; ENSG00000082175 [P06401-5]
ENST00000325455; ENSP00000325120; ENSG00000082175 [P06401-1]
ENST00000534013; ENSP00000436561; ENSG00000082175 [P06401-3]
GeneIDi5241
KEGGihsa:5241
UCSCiuc001pgh.3 human [P06401-1]

Organism-specific databases

CTDi5241
DisGeNETi5241
EuPathDBiHostDB:ENSG00000082175.14
GeneCardsiPGR
HGNCiHGNC:8910 PGR
HPAiCAB000068
CAB055100
HPA004751
HPA008428
HPA017176
MalaCardsiPGR
MIMi607311 gene
neXtProtiNX_P06401
OpenTargetsiENSG00000082175
PharmGKBiPA266
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00760000118887
HOGENOMiHOG000290653
HOVERGENiHBG007583
InParanoidiP06401
KOiK08556
OMAiCAYPPDA
OrthoDBiEOG091G04YC
PhylomeDBiP06401
TreeFamiTF106510

Enzyme and pathway databases

ReactomeiR-HSA-1251985 Nuclear signaling by ERBB4
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-4090294 SUMOylation of intracellular receptors
R-HSA-9018519 Estrogen-dependent gene expression
SignaLinkiP06401
SIGNORiP06401

Miscellaneous databases

ChiTaRSiPGR human
EvolutionaryTraceiP06401
GeneWikiiProgesterone_receptor
GenomeRNAii5241
PROiPR:P06401
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000082175 Expressed in 153 organ(s), highest expression level in endometrium
CleanExiHS_PGR
ExpressionAtlasiP06401 baseline and differential
GenevisibleiP06401 HS

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR000128 Progest_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF02161 Prog_receptor, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00544 PROGESTRONER
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 2 hits
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRGR_HUMAN
AccessioniPrimary (citable) accession number: P06401
Secondary accession number(s): A7LQ08
, A7X8B0, B4E3T0, Q8TDS3, Q9UPF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: March 21, 2006
Last modified: September 12, 2018
This is version 231 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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