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UniProtKB - P06401 (PRGR_HUMAN)

Entry version 235 (13 Feb 2019)
Sequence version 4 (21 Mar 2006)
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Protein

Progesterone receptor

Gene

PGR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.Curated3 Publications
Isoform A: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2.Curated3 Publications
Isoform B: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.1 Publication
Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi567 – 639Nuclear receptorPROSITE-ProRule annotationAdd BLAST73
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri567 – 587NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri603 – 627NR C4-typePROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandLipid-binding, Metal-binding, Steroid-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1251985 Nuclear signaling by ERBB4
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-4090294 SUMOylation of intracellular receptors
R-HSA-9018519 Estrogen-dependent gene expression

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P06401

SIGNOR Signaling Network Open Resource

More...SIGNORi		P06401

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000001574

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Progesterone receptor
Short name:
PR
Alternative name(s):
Nuclear receptor subfamily 3 group C member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PGR
Synonyms:NR3C3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000082175.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:8910 PGR

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607311 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P06401

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi7K → R: Some loss of sumoylation; when associated with R-531. Complete loss of sumoylation; when associated with R-388 and R-531. 1 Publication1
Mutagenesisi55L → A: Reduces transcriptional activation; when associated with A-58 and A-59. 1 Publication1
Mutagenesisi58L → A: Reduces transcriptional activation; when associated with A-55 and A-59. 1 Publication1
Mutagenesisi59L → A: Reduces transcriptional activation; when associated with A-55 and A-58. 1 Publication1
Mutagenesisi115L → A: Reduces transcriptional activation; when associated with A-118 and A-119. 1 Publication1
Mutagenesisi118L → A: Reduces transcriptional activation; when associated with A-115 and A-119. 1 Publication1
Mutagenesisi119L → A: Reduces transcriptional activation; when associated with A-115 and A-118. 1 Publication1
Mutagenesisi140W → A, F or R: Reduces transcriptional activation. 1 Publication1
Mutagenesisi294S → A: No effect on interaction with CUEDC2. Impaired progesterone-induced transcriptional activity. No CUEDC2- nor progestin-mediated protein degradation. No change in sumoylation; when associated with A-344 and A-345. 3 Publications1
Mutagenesisi294S → D: Decreases protein stability and increases progesterone-induced transcriptional activity. 3 Publications1
Mutagenesisi344S → A: No interaction with SP1. No change in progestin-induced protein degradation; when associated with A-345. No change in sumoylation; when associated with A-294 and A-345. 2 Publications1
Mutagenesisi345S → A: No change in progestin-induced protein degradation; when associated with A-344. No change in sumoylation; when associated with A-294 and A-344. 2 Publications1
Mutagenesisi388K → R: Great loss of sumoylation; when associated with R-7. Completely abolishes sumoylation; when associated with R-7 and R-531. Loss of CUEDC2-mediated protein degradation. Increased ligand-dependent transcriptional activity. 3 Publications1
Mutagenesisi400S → A: Abolishes CDK2-induced activity in the absence, but not in the presence, of progestin. Delayed nuclear translocation in presence of progestin. 2 Publications1
Mutagenesisi531K → R: Some loss of sumoylation; when associated with R-7. Completely abolishes sumoylation; when associated with R-7 and R-388. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		5241

MalaCards human disease database

More...MalaCardsi		PGR

Open Targets

More...OpenTargetsi		ENSG00000082175

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA266

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL208

Drug and drug target database

More...DrugBanki		DB01431 Allylestrenol
DB01406 Danazol
DB00304 Desogestrel
DB01395 Drospirenone
DB00378 Dydrogesterone
DB00823 Ethynodiol diacetate
DB00294 Etonogestrel
DB00588 Fluticasone Propionate
DB06789 Hydroxyprogesterone caproate
DB00367 Levonorgestrel
DB00603 Medroxyprogesterone acetate
DB00351 Megestrol acetate
DB02998 Methyltrienolone
DB00834 Mifepristone
DB06713 Norelgestromin
DB00717 Norethisterone
DB00957 Norgestimate
DB09389 Norgestrel
DB05253 Proellex
DB00396 Progesterone
DB00421 Spironolactone
DB04787 Tanaproget
DB08867 Ulipristal

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		627

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PGR

Domain mapping of disease mutations (DMDM)

More...DMDMi		90110048

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000536931 – 933Progesterone receptorAdd BLAST933

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki7Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei20Phosphoserine1 Publication1
Modified residuei81Phosphoserine2 Publications1
Modified residuei102Phosphoserine2 Publications1
Modified residuei130Phosphoserine1 Publication1
Modified residuei162PhosphoserineCombined sources5 Publications1
Modified residuei190Phosphoserine4 Publications1
Modified residuei213Phosphoserine1 Publication1
Modified residuei294Phosphoserine; by MAPK17 Publications1
Modified residuei345Phosphoserine; by MAPK3 Publications1
Cross-linki388Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Cross-linki388Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication
Modified residuei400Phosphoserine; by CDK23 Publications1
Cross-linki531Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Modified residuei676Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on multiple serine sites. Several of these sites are hormone-dependent. Phosphorylation on Ser-294 occurs preferentially on isoform B, is highly hormone-dependent and modulates ubiquitination and sumoylation on Lys-388. Phosphorylation on Ser-102 and Ser-345 also requires induction by hormone. Basal phosphorylation on Ser-81, Ser-162, Ser-190 and Ser-400 is increased in response to progesterone and can be phosphorylated in vitro by the CDK2-A1 complex. Increased levels of phosphorylation on Ser-400 also in the presence of EGF, heregulin, IGF, PMA and FBS. Phosphorylation at this site by CDK2 is ligand-independent, and increases nuclear translocation and transcriptional activity. Phosphorylation at Ser-162 and Ser-294, but not at Ser-190, is impaired during the G2/M phase of the cell cycle. Phosphorylation on Ser-345 by ERK1/2 MAPK is required for interaction with SP1.13 Publications
Sumoylation is hormone-dependent and represses transcriptional activity. Sumoylation on all three sites is enhanced by PIAS3. Desumoylated by SENP1. Sumoylation on Lys-388, the main site of sumoylation, is repressed by ubiquitination on the same site, and modulated by phosphorylation at Ser-294.9 Publications
Ubiquitination is hormone-dependent and represses sumoylation on the same site. Promoted by MAPK-mediated phosphorylation on Ser-294.7 Publications
Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation.1 Publication

Keywords - PTMi

Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P06401

MaxQB - The MaxQuant DataBase

More...MaxQBi		P06401

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P06401

PeptideAtlas

More...PeptideAtlasi		P06401

PRoteomics IDEntifications database

More...PRIDEi		P06401

ProteomicsDB human proteome resource

More...ProteomicsDBi		51901
51902 [P06401-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P06401

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P06401

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P06401

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In reproductive tissues the expression of isoform A and isoform B varies as a consequence of developmental and hormonal status. Isoform A and isoform B are expressed in comparable levels in uterine glandular epithelium during the proliferative phase of the menstrual cycle. Expression of isoform B but not of isoform A persists in the glands during mid-secretory phase. In the stroma, isoform A is the predominant form throughout the cycle. Heterogeneous isoform expression between the glands of the endometrium basalis and functionalis is implying region-specific responses to hormonal stimuli.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000082175 Expressed in 153 organ(s), highest expression level in endometrium

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P06401 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P06401 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB000068
CAB055100
HPA004751
HPA008428
HPA017176

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SMARD1 and UNC45A. Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and represses transcriptional activity. Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export. Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2 MAPK. Interacts with PRMT2. Isoform A interacts with NCOR2. Isoform B (but not isoform A) interacts with NCOA2 and NCOA1. Isoform B (but not isoform A) interacts with KLF9. Interacts with GTF2B (PubMed:1517211).By similarity8 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		111260, 68 interactors

Database of interacting proteins

More...DIPi		DIP-5967N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P06401

Protein interaction database and analysis system

More...IntActi		P06401, 14 interactors

Molecular INTeraction database

More...MINTi		P06401

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000325120

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P06401

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1933
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A28X-ray1.80A/B678-933[»]
1E3KX-ray2.80A/B676-933[»]
1SQNX-ray1.45A/B673-933[»]
1SR7X-ray1.46A/B676-933[»]
1ZUCX-ray2.00A/B676-933[»]
2C7AX-ray2.50A/B563-640[»]
2OVHX-ray2.00A678-933[»]
2OVMX-ray2.60A678-933[»]
2W8YX-ray1.80A/B678-933[»]
3D90X-ray2.26A/B676-933[»]
3G8OX-ray1.90A/B673-933[»]
3HQ5X-ray2.10A/B678-933[»]
3KBAX-ray2.00A/B681-933[»]
3ZR7X-ray1.65A/B678-933[»]
3ZRAX-ray1.90A/B678-933[»]
3ZRBX-ray1.80A/B678-933[»]
4A2JX-ray2.00A/B678-933[»]
4APUX-ray1.90A/B678-933[»]
4OARX-ray2.41A678-933[»]
5CC0X-ray2.40A/B561-641[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P06401

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P06401

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P06401

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini679 – 913NR LBDPROSITE-ProRule annotationAdd BLAST235

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 566Modulating, Pro-RichAdd BLAST566
Regioni1 – 164AF3; mediates transcriptional activation (in isoform B)1 PublicationAdd BLAST164
Regioni165 – 305Mediates transcriptional transrepression (in isoform A)1 PublicationAdd BLAST141
Regioni456 – 546AF1; mediates transcriptional activation1 PublicationAdd BLAST91
Regioni687 – 933AF2; mediates transcriptional activation1 PublicationAdd BLAST247

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi55 – 59LXXL motif 11 Publication5
Motifi115 – 119LXXL motif 21 Publication5
Motifi183 – 187Nuclear localization signalSequence analysis5

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nuclear hormone receptor family. NR3 subfamily.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri567 – 587NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri603 – 627NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3575 Eukaryota
ENOG410XRZC LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159713

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000290653

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG007583

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P06401

KEGG Orthology (KO)

More...KOi		K08556

Identification of Orthologs from Complete Genome Data

More...OMAi		YGDFQPP

Database of Orthologous Groups

More...OrthoDBi		615449at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P06401

TreeFam database of animal gene trees

More...TreeFami		TF106510

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.50.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR000128 Progest_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00104 Hormone_recep, 1 hit
PF02161 Prog_receptor, 1 hit
PF00105 zf-C4, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00544 PROGESTRONER
PR00398 STRDHORMONER
PR00047 STROIDFINGER

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48508 SSF48508, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform B (identifier: P06401-1) [UniParc]FASTAAdd to basket
Also known as: PRB, PR-B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTELKAKGPR APHVAGGPPS PEVGSPLLCR PAAGPFPGSQ TSDTLPEVSA 
        60         70         80         90        100
IPISLDGLLF PRPCQGQDPS DEKTQDQQSL SDVEGAYSRA EATRGAGGSS 
       110        120        130        140        150
SSPPEKDSGL LDSVLDTLLA PSGPGQSQPS PPACEVTSSW CLFGPELPED 
       160        170        180        190        200
PPAAPATQRV LSPLMSRSGC KVGDSSGTAA AHKVLPRGLS PARQLLLPAS 
       210        220        230        240        250
ESPHWSGAPV KPSPQAAAVE VEEEDGSESE ESAGPLLKGK PRALGGAAAG 
       260        270        280        290        300
GGAAAVPPGA AAGGVALVPK EDSRFSAPRV ALVEQDAPMA PGRSPLATTV 
       310        320        330        340        350
MDFIHVPILP LNHALLAART RQLLEDESYD GGAGAASAFA PPRSSPCASS 
       360        370        380        390        400
TPVAVGDFPD CAYPPDAEPK DDAYPLYSDF QPPALKIKEE EEGAEASARS 
       410        420        430        440        450
PRSYLVAGAN PAAFPDFPLG PPPPLPPRAT PSRPGEAAVT AAPASASVSS 
       460        470        480        490        500
ASSSGSTLEC ILYKAEGAPP QQGPFAPPPC KAPGASGCLL PRDGLPSTSA 
       510        520        530        540        550
SAAAAGAAPA LYPALGLNGL PQLGYQAAVL KEGLPQVYPP YLNYLRPDSE 
       560        570        580        590        600
ASQSPQYSFE SLPQKICLIC GDEASGCHYG VLTCGSCKVF FKRAMEGQHN 
       610        620        630        640        650
YLCAGRNDCI VDKIRRKNCP ACRLRKCCQA GMVLGGRKFK KFNKVRVVRA 
       660        670        680        690        700
LDAVALPQPV GVPNESQALS QRFTFSPGQD IQLIPPLINL LMSIEPDVIY 
       710        720        730        740        750
AGHDNTKPDT SSSLLTSLNQ LGERQLLSVV KWSKSLPGFR NLHIDDQITL 
       760        770        780        790        800
IQYSWMSLMV FGLGWRSYKH VSGQMLYFAP DLILNEQRMK ESSFYSLCLT 
       810        820        830        840        850
MWQIPQEFVK LQVSQEEFLC MKVLLLLNTI PLEGLRSQTQ FEEMRSSYIR 
       860        870        880        890        900
ELIKAIGLRQ KGVVSSSQRF YQLTKLLDNL HDLVKQLHLY CLNTFIQSRA 
       910        920        930 
LSVEFPEMMS EVIAAQLPKI LAGMVKPLLF HKK
Note: Produced by alternative promoter usage.
Length:933
Mass (Da):98,981
Last modified:March 21, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80452E54FF3A0454
GO
Isoform A (identifier: P06401-2) [UniParc]FASTAAdd to basket
Also known as: PRA, PR-A

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:769
Mass (Da):82,295
Checksum:iFE676F25282983F3
GO
Isoform 3 (identifier: P06401-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-594: Missing.

Note: Produced by alternative splicing of isoform B.
Show »
Length:339
Mass (Da):38,798
Checksum:i4496D6B5A4EC95FD
GO
Isoform 4 (identifier: P06401-4) [UniParc]FASTAAdd to basket
Also known as: PR-M

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MTELKAKGPRAPHVAG → MEFIYIYMNFFFFFSV
     17-635: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:314
Mass (Da):36,318
Checksum:iA85692E905BFB9B3
GO
Isoform 5 (identifier: P06401-5) [UniParc]FASTAAdd to basket
Also known as: delta4

The sequence of this isoform differs from the canonical sequence as follows:
     636-737: Missing.

Note: Produced by alternative splicing of isoform B.
Show »
Length:831
Mass (Da):87,747
Checksum:iEC4882171DD1C48B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8NG45Q8NG45_HUMAN
Progesterone receptor, isoform CRA_...
PGR PR, hCG_39657
695Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8NG42Q8NG42_HUMAN
Delta 6/2 progesterone receptor
PGR PR, hCG_39657
803Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8NG44Q8NG44_HUMAN
Delta 3+6/2 progesterone receptor
PGR PR, hCG_39657
764Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WXR4A0A087WXR4_HUMAN
Progesterone receptor
PGR
690Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YVP1A0A0J9YVP1_HUMAN
Progesterone receptor
PGR
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti226G → S in CAA36018 (PubMed:2328727).Curated1
Sequence conflicti256V → S in CAA36018 (PubMed:2328727).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01922150A → T1 PublicationCorresponds to variant dbSNP:rs11571143Ensembl.1
Natural variantiVAR_019222120A → V1 PublicationCorresponds to variant dbSNP:rs11571144Ensembl.1
Natural variantiVAR_019223186P → L1 PublicationCorresponds to variant dbSNP:rs11571145Ensembl.1
Natural variantiVAR_019224301M → R1 PublicationCorresponds to variant dbSNP:rs11571146Ensembl.1
Natural variantiVAR_016117344S → T2 PublicationsCorresponds to variant dbSNP:rs3740753Ensembl.1
Natural variantiVAR_025555347C → S. Corresponds to variant dbSNP:rs11571147Ensembl.1
Natural variantiVAR_019225444A → S1 PublicationCorresponds to variant dbSNP:rs11571150Ensembl.1
Natural variantiVAR_019226529V → L1 PublicationCorresponds to variant dbSNP:rs11571151Ensembl.1
Natural variantiVAR_019227536Q → P1 PublicationCorresponds to variant dbSNP:rs11571152Ensembl.1
Natural variantiVAR_014627625R → I. Corresponds to variant dbSNP:rs2020874Ensembl.1
Natural variantiVAR_019228651L → V1 PublicationCorresponds to variant dbSNP:rs11571222Ensembl.1
Natural variantiVAR_016118660V → L3 PublicationsCorresponds to variant dbSNP:rs1042838Ensembl.1
Natural variantiVAR_014628865S → L1 PublicationCorresponds to variant dbSNP:rs2020880Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0469421 – 594Missing in isoform 3. 1 PublicationAdd BLAST594
Alternative sequenceiVSP_0037061 – 164Missing in isoform A. CuratedAdd BLAST164
Alternative sequenceiVSP_0474541 – 16MTELK…PHVAG → MEFIYIYMNFFFFFSV in isoform 4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_04745517 – 635Missing in isoform 4. 1 PublicationAdd BLAST619
Alternative sequenceiVSP_053543636 – 737Missing in isoform 5. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X51730 mRNA Translation: CAA36018.1
M15716 mRNA Translation: AAA60081.1
AF016381 mRNA Translation: AAD01587.1
AB084248 mRNA Translation: BAB91074.1
DQ234979 Genomic DNA Translation: ABB72139.1
AY212933 mRNA Translation: AAO61671.1
AK304853 mRNA Translation: BAG65592.1
AY525610 Genomic DNA Translation: AAS00096.1
AP001533 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW66999.1
CH471065 Genomic DNA Translation: EAW67000.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS59229.1 [P06401-3]
CCDS8310.1 [P06401-1]

Protein sequence database of the Protein Information Resource

More...PIRi		S09971 QRHUP

NCBI Reference Sequences

More...RefSeqi		NP_000917.3, NM_000926.4 [P06401-1]
NP_001189403.1, NM_001202474.3 [P06401-2]
NP_001258090.1, NM_001271161.2
NP_001258091.1, NM_001271162.1 [P06401-3]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.32405
Hs.742403

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263463; ENSP00000263463; ENSG00000082175 [P06401-5]
ENST00000325455; ENSP00000325120; ENSG00000082175 [P06401-1]
ENST00000534013; ENSP00000436561; ENSG00000082175 [P06401-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5241

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5241

UCSC genome browser

More...UCSCi		uc001pgh.3 human [P06401-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Wikipedia

Progesterone receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51730 mRNA Translation: CAA36018.1
M15716 mRNA Translation: AAA60081.1
AF016381 mRNA Translation: AAD01587.1
AB084248 mRNA Translation: BAB91074.1
DQ234979 Genomic DNA Translation: ABB72139.1
AY212933 mRNA Translation: AAO61671.1
AK304853 mRNA Translation: BAG65592.1
AY525610 Genomic DNA Translation: AAS00096.1
AP001533 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW66999.1
CH471065 Genomic DNA Translation: EAW67000.1
CCDSiCCDS59229.1 [P06401-3]
CCDS8310.1 [P06401-1]
PIRiS09971 QRHUP
RefSeqiNP_000917.3, NM_000926.4 [P06401-1]
NP_001189403.1, NM_001202474.3 [P06401-2]
NP_001258090.1, NM_001271161.2
NP_001258091.1, NM_001271162.1 [P06401-3]
UniGeneiHs.32405
Hs.742403

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A28X-ray1.80A/B678-933[»]
1E3KX-ray2.80A/B676-933[»]
1SQNX-ray1.45A/B673-933[»]
1SR7X-ray1.46A/B676-933[»]
1ZUCX-ray2.00A/B676-933[»]
2C7AX-ray2.50A/B563-640[»]
2OVHX-ray2.00A678-933[»]
2OVMX-ray2.60A678-933[»]
2W8YX-ray1.80A/B678-933[»]
3D90X-ray2.26A/B676-933[»]
3G8OX-ray1.90A/B673-933[»]
3HQ5X-ray2.10A/B678-933[»]
3KBAX-ray2.00A/B681-933[»]
3ZR7X-ray1.65A/B678-933[»]
3ZRAX-ray1.90A/B678-933[»]
3ZRBX-ray1.80A/B678-933[»]
4A2JX-ray2.00A/B678-933[»]
4APUX-ray1.90A/B678-933[»]
4OARX-ray2.41A678-933[»]
5CC0X-ray2.40A/B561-641[»]
ProteinModelPortaliP06401
SMRiP06401
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111260, 68 interactors
DIPiDIP-5967N
ELMiP06401
IntActiP06401, 14 interactors
MINTiP06401
STRINGi9606.ENSP00000325120

Chemistry databases

BindingDBiP06401
ChEMBLiCHEMBL208
DrugBankiDB01431 Allylestrenol
DB01406 Danazol
DB00304 Desogestrel
DB01395 Drospirenone
DB00378 Dydrogesterone
DB00823 Ethynodiol diacetate
DB00294 Etonogestrel
DB00588 Fluticasone Propionate
DB06789 Hydroxyprogesterone caproate
DB00367 Levonorgestrel
DB00603 Medroxyprogesterone acetate
DB00351 Megestrol acetate
DB02998 Methyltrienolone
DB00834 Mifepristone
DB06713 Norelgestromin
DB00717 Norethisterone
DB00957 Norgestimate
DB09389 Norgestrel
DB05253 Proellex
DB00396 Progesterone
DB00421 Spironolactone
DB04787 Tanaproget
DB08867 Ulipristal
GuidetoPHARMACOLOGYi627
SwissLipidsiSLP:000001574

PTM databases

iPTMnetiP06401
PhosphoSitePlusiP06401
SwissPalmiP06401

Polymorphism and mutation databases

BioMutaiPGR
DMDMi90110048

Proteomic databases

jPOSTiP06401
MaxQBiP06401
PaxDbiP06401
PeptideAtlasiP06401
PRIDEiP06401
ProteomicsDBi51901
51902 [P06401-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		5241
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263463; ENSP00000263463; ENSG00000082175 [P06401-5]
ENST00000325455; ENSP00000325120; ENSG00000082175 [P06401-1]
ENST00000534013; ENSP00000436561; ENSG00000082175 [P06401-3]
GeneIDi5241
KEGGihsa:5241
UCSCiuc001pgh.3 human [P06401-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5241
DisGeNETi5241
EuPathDBiHostDB:ENSG00000082175.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		PGR
HGNCiHGNC:8910 PGR
HPAiCAB000068
CAB055100
HPA004751
HPA008428
HPA017176
MalaCardsiPGR
MIMi607311 gene
neXtProtiNX_P06401
OpenTargetsiENSG00000082175
PharmGKBiPA266

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00940000159713
HOGENOMiHOG000290653
HOVERGENiHBG007583
InParanoidiP06401
KOiK08556
OMAiYGDFQPP
OrthoDBi615449at2759
PhylomeDBiP06401
TreeFamiTF106510

Enzyme and pathway databases

ReactomeiR-HSA-1251985 Nuclear signaling by ERBB4
R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-4090294 SUMOylation of intracellular receptors
R-HSA-9018519 Estrogen-dependent gene expression
SignaLinkiP06401
SIGNORiP06401

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PGR human
EvolutionaryTraceiP06401

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Progesterone_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5241

Protein Ontology

More...PROi		PR:P06401

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000082175 Expressed in 153 organ(s), highest expression level in endometrium
ExpressionAtlasiP06401 baseline and differential
GenevisibleiP06401 HS

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR000128 Progest_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF02161 Prog_receptor, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00544 PROGESTRONER
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRGR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P06401
Secondary accession number(s): A7LQ08
, A7X8B0, B4E3T0, Q8TDS3, Q9UPF7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: March 21, 2006
Last modified: February 13, 2019
This is version 235 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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