UniProtKB - P06401 (PRGR_HUMAN)
Progesterone receptor
PGR
Functioni
The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor.
Curated3 PublicationsLigand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2.
Curated3 PublicationsTranscriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.
1 PublicationIncreases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 567 – 639 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 73 | |
Zinc fingeri | 567 – 587 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 603 – 627 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- ATPase binding Source: MGI
- DNA binding Source: ProtInc
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- enzyme binding Source: UniProtKB
- identical protein binding Source: IntAct
- nuclear receptor activity Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- signaling receptor binding Source: UniProtKB
- steroid binding Source: UniProtKB-KW
- steroid hormone receptor activity Source: ProtInc
- transcription coactivator binding Source: ARUK-UCL
- zinc ion binding Source: InterPro
GO - Biological processi
- cell-cell signaling Source: ProtInc
- epithelial cell maturation Source: Ensembl
- intracellular steroid hormone receptor signaling pathway Source: GO_Central
- lung alveolus development Source: Ensembl
- negative regulation of gene expression Source: UniProtKB
- ovulation from ovarian follicle Source: Ensembl
- paracrine signaling Source: Ensembl
- positive regulation of gene expression Source: ARUK-UCL
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- progesterone receptor signaling pathway Source: Ensembl
- regulation of epithelial cell proliferation Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- signal transduction Source: ProtInc
- tertiary branching involved in mammary gland duct morphogenesis Source: Ensembl
Keywordsi
Molecular function | DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Lipid-binding, Metal-binding, Steroid-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P06401 |
Reactomei | R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-4090294, SUMOylation of intracellular receptors R-HSA-9018519, Estrogen-dependent gene expression |
SignaLinki | P06401 |
SIGNORi | P06401 |
Protein family/group databases
TCDBi | 9.B.208.1.5, the vitamin d3 receptor (vdr) family |
Chemistry databases
SwissLipidsi | SLP:000001574 |
Names & Taxonomyi
Protein namesi | Recommended name: Progesterone receptorShort name: PR Alternative name(s): Nuclear receptor subfamily 3 group C member 3 |
Gene namesi | Name:PGR Synonyms:NR3C3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:8910, PGR |
MIMi | 607311, gene |
neXtProti | NX_P06401 |
VEuPathDBi | HostDB:ENSG00000082175 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Mitochondrion
- mitochondrial outer membrane Source: UniProtKB-SubCell
Nucleus
- nucleoplasm Source: Reactome
Other locations
- chromatin Source: NTNU_SB
Keywords - Cellular componenti
Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 7 | K → R: Some loss of sumoylation; when associated with R-531. Complete loss of sumoylation; when associated with R-388 and R-531. 1 Publication | 1 | |
Mutagenesisi | 55 | L → A: Reduces transcriptional activation; when associated with A-58 and A-59. 1 Publication | 1 | |
Mutagenesisi | 58 | L → A: Reduces transcriptional activation; when associated with A-55 and A-59. 1 Publication | 1 | |
Mutagenesisi | 59 | L → A: Reduces transcriptional activation; when associated with A-55 and A-58. 1 Publication | 1 | |
Mutagenesisi | 115 | L → A: Reduces transcriptional activation; when associated with A-118 and A-119. 1 Publication | 1 | |
Mutagenesisi | 118 | L → A: Reduces transcriptional activation; when associated with A-115 and A-119. 1 Publication | 1 | |
Mutagenesisi | 119 | L → A: Reduces transcriptional activation; when associated with A-115 and A-118. 1 Publication | 1 | |
Mutagenesisi | 140 | W → A, F or R: Reduces transcriptional activation. 1 Publication | 1 | |
Mutagenesisi | 294 | S → A: No effect on interaction with CUEDC2. Impaired progesterone-induced transcriptional activity. No CUEDC2- nor progestin-mediated protein degradation. No change in sumoylation; when associated with A-344 and A-345. 3 Publications | 1 | |
Mutagenesisi | 294 | S → D: Decreases protein stability and increases progesterone-induced transcriptional activity. 3 Publications | 1 | |
Mutagenesisi | 344 | S → A: No interaction with SP1. No change in progestin-induced protein degradation; when associated with A-345. No change in sumoylation; when associated with A-294 and A-345. 2 Publications | 1 | |
Mutagenesisi | 345 | S → A: No change in progestin-induced protein degradation; when associated with A-344. No change in sumoylation; when associated with A-294 and A-344. 2 Publications | 1 | |
Mutagenesisi | 388 | K → R: Great loss of sumoylation; when associated with R-7. Completely abolishes sumoylation; when associated with R-7 and R-531. Loss of CUEDC2-mediated protein degradation. Increased ligand-dependent transcriptional activity. 3 Publications | 1 | |
Mutagenesisi | 400 | S → A: Abolishes CDK2-induced activity in the absence, but not in the presence, of progestin. Delayed nuclear translocation in presence of progestin. 2 Publications | 1 | |
Mutagenesisi | 531 | K → R: Some loss of sumoylation; when associated with R-7. Completely abolishes sumoylation; when associated with R-7 and R-388. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 5241 |
MalaCardsi | PGR |
OpenTargetsi | ENSG00000082175 |
PharmGKBi | PA266 |
Miscellaneous databases
Pharosi | P06401, Tclin |
Chemistry databases
ChEMBLi | CHEMBL208 |
DrugBanki | DB01431, Allylestrenol DB06680, Asoprisnil DB01406, Danazol DB12941, Darolutamide DB13857, Demegestone DB00304, Desogestrel DB09123, Dienogest DB01395, Drospirenone DB00378, Dydrogesterone DB11219, Enzacamene DB00823, Ethynodiol diacetate DB00294, Etonogestrel DB13867, Fluticasone DB08906, Fluticasone furoate DB00588, Fluticasone propionate DB06730, Gestodene DB11619, Gestrinone DB11064, Homosalate DB06789, Hydroxyprogesterone caproate DB00367, Levonorgestrel DB00431, Lindane DB09124, Medrogestone DB00603, Medroxyprogesterone acetate DB00351, Megestrol acetate DB02998, Metribolone DB00834, Mifepristone DB00648, Mitotane DB00764, Mometasone DB14512, Mometasone furoate DB06713, Norelgestromin DB00717, Norethisterone DB00957, Norgestimate DB09389, Norgestrel DB01428, Oxybenzone DB02746, Phthalic Acid DB00396, Progesterone DB14583, Segesterone acetate DB00421, Spironolactone DB04787, Tanaproget DB05253, Telapristone acetate DB08867, Ulipristal |
DrugCentrali | P06401 |
GuidetoPHARMACOLOGYi | 627 |
Genetic variation databases
BioMutai | PGR |
DMDMi | 90110048 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053693 | 1 – 933 | Progesterone receptorAdd BLAST | 933 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 7 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication | ||
Modified residuei | 20 | Phosphoserine1 Publication | 1 | |
Modified residuei | 81 | Phosphoserine2 Publications | 1 | |
Modified residuei | 102 | Phosphoserine2 Publications | 1 | |
Modified residuei | 130 | Phosphoserine1 Publication | 1 | |
Modified residuei | 162 | PhosphoserineCombined sources5 Publications | 1 | |
Modified residuei | 190 | Phosphoserine4 Publications | 1 | |
Modified residuei | 213 | Phosphoserine1 Publication | 1 | |
Modified residuei | 294 | Phosphoserine; by MAPK17 Publications | 1 | |
Modified residuei | 345 | Phosphoserine; by MAPK3 Publications | 1 | |
Cross-linki | 388 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate | ||
Cross-linki | 388 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate1 Publication | ||
Modified residuei | 400 | Phosphoserine; by CDK23 Publications | 1 | |
Cross-linki | 531 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication | ||
Modified residuei | 676 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | P06401 |
MassIVEi | P06401 |
MaxQBi | P06401 |
PaxDbi | P06401 |
PeptideAtlasi | P06401 |
PRIDEi | P06401 |
ProteomicsDBi | 51901 [P06401-1] 51902 [P06401-2] 5919 74334 |
PTM databases
GlyGeni | P06401, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P06401 |
PhosphoSitePlusi | P06401 |
SwissPalmi | P06401 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000082175, Expressed in endometrium and 173 other tissues |
ExpressionAtlasi | P06401, baseline and differential |
Genevisiblei | P06401, HS |
Organism-specific databases
HPAi | ENSG00000082175, Group enriched (cervix, endometrium, fallopian tube, smooth muscle) |
Interactioni
Subunit structurei
Interacts with SMARD1 and UNC45A.
Interacts with CUEDC2; the interaction promotes ubiquitination, decreases sumoylation, and represses transcriptional activity.
Interacts with PIAS3; the interaction promotes sumoylation of PR in a hormone-dependent manner, inhibits DNA-binding, and alters nuclear export.
Interacts with SP1; the interaction requires ligand-induced phosphorylation on Ser-345 by ERK1/2 MAPK.
Interacts with PRMT2. Isoform A interacts with NCOR2. Isoform B (but not isoform A) interacts with NCOA2 and NCOA1. Isoform B (but not isoform A) interacts with KLF9.
Interacts with GTF2B (PubMed:1517211).
By similarity8 PublicationsBinary interactionsi
P06401
With | #Exp. | IntAct |
---|---|---|
CUEDC2 [Q9H467] | 9 | EBI-78539,EBI-1248228 |
ESR1 [P03372] | 20 | EBI-78539,EBI-78473 |
itself | 2 | EBI-78539,EBI-78539 |
STAT3 [P40763] | 3 | EBI-78539,EBI-518675 |
Isoform B [P06401-1]
With | #Exp. | IntAct |
---|---|---|
ESR1 [P03372] | 4 | EBI-12590474,EBI-78473 |
GO - Molecular functioni
- ATPase binding Source: MGI
- enzyme binding Source: UniProtKB
- identical protein binding Source: IntAct
- signaling receptor binding Source: UniProtKB
- transcription coactivator binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 111260, 70 interactors |
DIPi | DIP-5967N |
ELMi | P06401 |
IntActi | P06401, 89 interactors |
MINTi | P06401 |
STRINGi | 9606.ENSP00000325120 |
Chemistry databases
BindingDBi | P06401 |
Miscellaneous databases
RNActi | P06401, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P06401 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P06401 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 679 – 913 | NR LBDPROSITE-ProRule annotationAdd BLAST | 235 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 566 | Modulating, Pro-RichAdd BLAST | 566 | |
Regioni | 1 – 164 | AF3; mediates transcriptional activation (in isoform B)1 PublicationAdd BLAST | 164 | |
Regioni | 1 – 157 | DisorderedSequence analysisAdd BLAST | 157 | |
Regioni | 165 – 305 | Mediates transcriptional transrepression (in isoform A)1 PublicationAdd BLAST | 141 | |
Regioni | 195 – 241 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 331 – 351 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 415 – 452 | DisorderedSequence analysisAdd BLAST | 38 | |
Regioni | 456 – 546 | AF1; mediates transcriptional activation1 PublicationAdd BLAST | 91 | |
Regioni | 687 – 933 | AF2; mediates transcriptional activation1 PublicationAdd BLAST | 247 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 55 – 59 | LXXL motif 11 Publication | 5 | |
Motifi | 115 – 119 | LXXL motif 21 Publication | 5 | |
Motifi | 183 – 187 | Nuclear localization signalSequence analysis | 5 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 68 – 84 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 120 – 135 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 415 – 431 | Pro residuesSequence analysisAdd BLAST | 17 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 567 – 587 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 603 – 627 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000159713 |
HOGENOMi | CLU_014081_0_0_1 |
InParanoidi | P06401 |
OMAi | YKAEGAQ |
OrthoDBi | 615449at2759 |
PhylomeDBi | P06401 |
TreeFami | TF106510 |
Family and domain databases
DisProti | DP01542 |
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR000128, Progest_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF02161, Prog_receptor, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00544, PROGESTRONER PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative promoter usage and alternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTELKAKGPR APHVAGGPPS PEVGSPLLCR PAAGPFPGSQ TSDTLPEVSA
60 70 80 90 100
IPISLDGLLF PRPCQGQDPS DEKTQDQQSL SDVEGAYSRA EATRGAGGSS
110 120 130 140 150
SSPPEKDSGL LDSVLDTLLA PSGPGQSQPS PPACEVTSSW CLFGPELPED
160 170 180 190 200
PPAAPATQRV LSPLMSRSGC KVGDSSGTAA AHKVLPRGLS PARQLLLPAS
210 220 230 240 250
ESPHWSGAPV KPSPQAAAVE VEEEDGSESE ESAGPLLKGK PRALGGAAAG
260 270 280 290 300
GGAAAVPPGA AAGGVALVPK EDSRFSAPRV ALVEQDAPMA PGRSPLATTV
310 320 330 340 350
MDFIHVPILP LNHALLAART RQLLEDESYD GGAGAASAFA PPRSSPCASS
360 370 380 390 400
TPVAVGDFPD CAYPPDAEPK DDAYPLYSDF QPPALKIKEE EEGAEASARS
410 420 430 440 450
PRSYLVAGAN PAAFPDFPLG PPPPLPPRAT PSRPGEAAVT AAPASASVSS
460 470 480 490 500
ASSSGSTLEC ILYKAEGAPP QQGPFAPPPC KAPGASGCLL PRDGLPSTSA
510 520 530 540 550
SAAAAGAAPA LYPALGLNGL PQLGYQAAVL KEGLPQVYPP YLNYLRPDSE
560 570 580 590 600
ASQSPQYSFE SLPQKICLIC GDEASGCHYG VLTCGSCKVF FKRAMEGQHN
610 620 630 640 650
YLCAGRNDCI VDKIRRKNCP ACRLRKCCQA GMVLGGRKFK KFNKVRVVRA
660 670 680 690 700
LDAVALPQPV GVPNESQALS QRFTFSPGQD IQLIPPLINL LMSIEPDVIY
710 720 730 740 750
AGHDNTKPDT SSSLLTSLNQ LGERQLLSVV KWSKSLPGFR NLHIDDQITL
760 770 780 790 800
IQYSWMSLMV FGLGWRSYKH VSGQMLYFAP DLILNEQRMK ESSFYSLCLT
810 820 830 840 850
MWQIPQEFVK LQVSQEEFLC MKVLLLLNTI PLEGLRSQTQ FEEMRSSYIR
860 870 880 890 900
ELIKAIGLRQ KGVVSSSQRF YQLTKLLDNL HDLVKQLHLY CLNTFIQSRA
910 920 930
LSVEFPEMMS EVIAAQLPKI LAGMVKPLLF HKK
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ8NG44 | Q8NG44_HUMAN | Progesterone receptor | PGR PR, hCG_39657 | 764 | Annotation score: | ||
Q8NG45 | Q8NG45_HUMAN | Progesterone receptor | PGR PR, hCG_39657 | 695 | Annotation score: | ||
Q8NG42 | Q8NG42_HUMAN | Progesterone receptor | PGR PR, hCG_39657 | 803 | Annotation score: | ||
A0A087WXR4 | A0A087WXR4_HUMAN | Progesterone receptor | PGR | 690 | Annotation score: | ||
A0A0J9YVP1 | A0A0J9YVP1_HUMAN | Progesterone receptor | PGR | 170 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 226 | G → S in CAA36018 (PubMed:2328727).Curated | 1 | |
Sequence conflicti | 256 | V → S in CAA36018 (PubMed:2328727).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019221 | 50 | A → T1 PublicationCorresponds to variant dbSNP:rs11571143Ensembl. | 1 | |
Natural variantiVAR_019222 | 120 | A → V1 PublicationCorresponds to variant dbSNP:rs11571144EnsemblClinVar. | 1 | |
Natural variantiVAR_019223 | 186 | P → L1 PublicationCorresponds to variant dbSNP:rs11571145Ensembl. | 1 | |
Natural variantiVAR_019224 | 301 | M → R1 PublicationCorresponds to variant dbSNP:rs11571146Ensembl. | 1 | |
Natural variantiVAR_016117 | 344 | S → T2 PublicationsCorresponds to variant dbSNP:rs3740753Ensembl. | 1 | |
Natural variantiVAR_025555 | 347 | C → S. Corresponds to variant dbSNP:rs11571147EnsemblClinVar. | 1 | |
Natural variantiVAR_019225 | 444 | A → S1 PublicationCorresponds to variant dbSNP:rs11571150Ensembl. | 1 | |
Natural variantiVAR_019226 | 529 | V → L1 PublicationCorresponds to variant dbSNP:rs11571151Ensembl. | 1 | |
Natural variantiVAR_019227 | 536 | Q → P1 PublicationCorresponds to variant dbSNP:rs11571152EnsemblClinVar. | 1 | |
Natural variantiVAR_014627 | 625 | R → I. Corresponds to variant dbSNP:rs2020874Ensembl. | 1 | |
Natural variantiVAR_019228 | 651 | L → V1 PublicationCorresponds to variant dbSNP:rs11571222EnsemblClinVar. | 1 | |
Natural variantiVAR_016118 | 660 | V → L3 PublicationsCorresponds to variant dbSNP:rs1042838Ensembl. | 1 | |
Natural variantiVAR_014628 | 865 | S → L1 PublicationCorresponds to variant dbSNP:rs2020880Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046942 | 1 – 594 | Missing in isoform 3. 1 PublicationAdd BLAST | 594 | |
Alternative sequenceiVSP_003706 | 1 – 164 | Missing in isoform A. CuratedAdd BLAST | 164 | |
Alternative sequenceiVSP_047454 | 1 – 16 | MTELK…PHVAG → MEFIYIYMNFFFFFSV in isoform 4. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_047455 | 17 – 635 | Missing in isoform 4. 1 PublicationAdd BLAST | 619 | |
Alternative sequenceiVSP_053543 | 636 – 737 | Missing in isoform 5. 1 PublicationAdd BLAST | 102 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X51730 mRNA Translation: CAA36018.1 M15716 mRNA Translation: AAA60081.1 AF016381 mRNA Translation: AAD01587.1 AB084248 mRNA Translation: BAB91074.1 DQ234979 Genomic DNA Translation: ABB72139.1 AY212933 mRNA Translation: AAO61671.1 AK304853 mRNA Translation: BAG65592.1 AY525610 Genomic DNA Translation: AAS00096.1 AP001533 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW66999.1 CH471065 Genomic DNA Translation: EAW67000.1 |
CCDSi | CCDS59229.1 [P06401-3] CCDS8310.1 [P06401-1] |
PIRi | S09971, QRHUP |
RefSeqi | NP_000917.3, NM_000926.4 [P06401-1] NP_001189403.1, NM_001202474.3 [P06401-2] NP_001258090.1, NM_001271161.2 NP_001258091.1, NM_001271162.1 [P06401-3] |
Genome annotation databases
Ensembli | ENST00000263463; ENSP00000263463; ENSG00000082175 [P06401-5] ENST00000325455; ENSP00000325120; ENSG00000082175 ENST00000534013; ENSP00000436561; ENSG00000082175 [P06401-3] |
GeneIDi | 5241 |
KEGGi | hsa:5241 |
MANE-Selecti | ENST00000325455.10; ENSP00000325120.5; NM_000926.4; NP_000917.3 |
UCSCi | uc001pgh.3, human [P06401-1] |
Keywords - Coding sequence diversityi
Alternative promoter usage, Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Wikipedia Progesterone receptor entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X51730 mRNA Translation: CAA36018.1 M15716 mRNA Translation: AAA60081.1 AF016381 mRNA Translation: AAD01587.1 AB084248 mRNA Translation: BAB91074.1 DQ234979 Genomic DNA Translation: ABB72139.1 AY212933 mRNA Translation: AAO61671.1 AK304853 mRNA Translation: BAG65592.1 AY525610 Genomic DNA Translation: AAS00096.1 AP001533 Genomic DNA No translation available. CH471065 Genomic DNA Translation: EAW66999.1 CH471065 Genomic DNA Translation: EAW67000.1 |
CCDSi | CCDS59229.1 [P06401-3] CCDS8310.1 [P06401-1] |
PIRi | S09971, QRHUP |
RefSeqi | NP_000917.3, NM_000926.4 [P06401-1] NP_001189403.1, NM_001202474.3 [P06401-2] NP_001258090.1, NM_001271161.2 NP_001258091.1, NM_001271162.1 [P06401-3] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1A28 | X-ray | 1.80 | A/B | 678-933 | [»] | |
1E3K | X-ray | 2.80 | A/B | 676-933 | [»] | |
1SQN | X-ray | 1.45 | A/B | 673-933 | [»] | |
1SR7 | X-ray | 1.46 | A/B | 676-933 | [»] | |
1ZUC | X-ray | 2.00 | A/B | 676-933 | [»] | |
2C7A | X-ray | 2.50 | A/B | 563-640 | [»] | |
2OVH | X-ray | 2.00 | A | 678-933 | [»] | |
2OVM | X-ray | 2.60 | A | 678-933 | [»] | |
2W8Y | X-ray | 1.80 | A/B | 678-933 | [»] | |
3D90 | X-ray | 2.26 | A/B | 676-933 | [»] | |
3G8O | X-ray | 1.90 | A/B | 673-933 | [»] | |
3HQ5 | X-ray | 2.10 | A/B | 678-933 | [»] | |
3KBA | X-ray | 2.00 | A/B | 681-933 | [»] | |
3ZR7 | X-ray | 1.65 | A/B | 678-933 | [»] | |
3ZRA | X-ray | 1.90 | A/B | 678-933 | [»] | |
3ZRB | X-ray | 1.80 | A/B | 678-933 | [»] | |
4A2J | X-ray | 2.00 | A/B | 678-933 | [»] | |
4APU | X-ray | 1.90 | A/B | 678-933 | [»] | |
4OAR | X-ray | 2.41 | A | 678-933 | [»] | |
5CC0 | X-ray | 2.40 | A/B | 561-641 | [»] | |
SMRi | P06401 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111260, 70 interactors |
DIPi | DIP-5967N |
ELMi | P06401 |
IntActi | P06401, 89 interactors |
MINTi | P06401 |
STRINGi | 9606.ENSP00000325120 |
Chemistry databases
BindingDBi | P06401 |
ChEMBLi | CHEMBL208 |
DrugBanki | DB01431, Allylestrenol DB06680, Asoprisnil DB01406, Danazol DB12941, Darolutamide DB13857, Demegestone DB00304, Desogestrel DB09123, Dienogest DB01395, Drospirenone DB00378, Dydrogesterone DB11219, Enzacamene DB00823, Ethynodiol diacetate DB00294, Etonogestrel DB13867, Fluticasone DB08906, Fluticasone furoate DB00588, Fluticasone propionate DB06730, Gestodene DB11619, Gestrinone DB11064, Homosalate DB06789, Hydroxyprogesterone caproate DB00367, Levonorgestrel DB00431, Lindane DB09124, Medrogestone DB00603, Medroxyprogesterone acetate DB00351, Megestrol acetate DB02998, Metribolone DB00834, Mifepristone DB00648, Mitotane DB00764, Mometasone DB14512, Mometasone furoate DB06713, Norelgestromin DB00717, Norethisterone DB00957, Norgestimate DB09389, Norgestrel DB01428, Oxybenzone DB02746, Phthalic Acid DB00396, Progesterone DB14583, Segesterone acetate DB00421, Spironolactone DB04787, Tanaproget DB05253, Telapristone acetate DB08867, Ulipristal |
DrugCentrali | P06401 |
GuidetoPHARMACOLOGYi | 627 |
SwissLipidsi | SLP:000001574 |
Protein family/group databases
TCDBi | 9.B.208.1.5, the vitamin d3 receptor (vdr) family |
PTM databases
GlyGeni | P06401, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P06401 |
PhosphoSitePlusi | P06401 |
SwissPalmi | P06401 |
Genetic variation databases
BioMutai | PGR |
DMDMi | 90110048 |
Proteomic databases
jPOSTi | P06401 |
MassIVEi | P06401 |
MaxQBi | P06401 |
PaxDbi | P06401 |
PeptideAtlasi | P06401 |
PRIDEi | P06401 |
ProteomicsDBi | 51901 [P06401-1] 51902 [P06401-2] 5919 74334 |
Protocols and materials databases
Antibodypediai | 1685, 2968 antibodies from 54 providers |
CPTCi | P06401, 2 antibodies |
DNASUi | 5241 |
Genome annotation databases
Ensembli | ENST00000263463; ENSP00000263463; ENSG00000082175 [P06401-5] ENST00000325455; ENSP00000325120; ENSG00000082175 ENST00000534013; ENSP00000436561; ENSG00000082175 [P06401-3] |
GeneIDi | 5241 |
KEGGi | hsa:5241 |
MANE-Selecti | ENST00000325455.10; ENSP00000325120.5; NM_000926.4; NP_000917.3 |
UCSCi | uc001pgh.3, human [P06401-1] |
Organism-specific databases
CTDi | 5241 |
DisGeNETi | 5241 |
GeneCardsi | PGR |
HGNCi | HGNC:8910, PGR |
HPAi | ENSG00000082175, Group enriched (cervix, endometrium, fallopian tube, smooth muscle) |
MalaCardsi | PGR |
MIMi | 607311, gene |
neXtProti | NX_P06401 |
OpenTargetsi | ENSG00000082175 |
PharmGKBi | PA266 |
VEuPathDBi | HostDB:ENSG00000082175 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000159713 |
HOGENOMi | CLU_014081_0_0_1 |
InParanoidi | P06401 |
OMAi | YKAEGAQ |
OrthoDBi | 615449at2759 |
PhylomeDBi | P06401 |
TreeFami | TF106510 |
Enzyme and pathway databases
PathwayCommonsi | P06401 |
Reactomei | R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-3371497, HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand R-HSA-383280, Nuclear Receptor transcription pathway R-HSA-4090294, SUMOylation of intracellular receptors R-HSA-9018519, Estrogen-dependent gene expression |
SignaLinki | P06401 |
SIGNORi | P06401 |
Miscellaneous databases
BioGRID-ORCSi | 5241, 3 hits in 1065 CRISPR screens |
ChiTaRSi | PGR, human |
EvolutionaryTracei | P06401 |
GeneWikii | Progesterone_receptor |
GenomeRNAii | 5241 |
Pharosi | P06401, Tclin |
PROi | PR:P06401 |
RNActi | P06401, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000082175, Expressed in endometrium and 173 other tissues |
ExpressionAtlasi | P06401, baseline and differential |
Genevisiblei | P06401, HS |
Family and domain databases
DisProti | DP01542 |
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR000128, Progest_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF02161, Prog_receptor, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00544, PROGESTRONER PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PRGR_HUMAN | |
Accessioni | P06401Primary (citable) accession number: P06401 Secondary accession number(s): A7LQ08 Q9UPF7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 1, 1988 |
Last sequence update: | March 21, 2006 | |
Last modified: | February 23, 2022 | |
This is version 252 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families